OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology Progress is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Lignin degradation by microorganisms: A review	60
Developments of biobased plasticizers for compostable polymers in the green packaging applications: A review	47
A novel pH‐responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan‐based nanocarrier: Emphasis on the concurrent improvement of loading, sustained release, and ap	44
Proliferation and differentiation of primary bovine myoblasts using Chlorella vulgaris extract for sustainable production of cultured meat	32
Computational drug repurposing study of the RNA binding domain of SARS‐CoV‐2 nucleocapsid protein with antiviral agents	30
In vitro hepatic steatosis model based on gut–liver‐on‐a‐chip	29
Green and sustainable route for oxidative depolymerization of lignin: New platform for fine chemicals and fuels	27
Economic assessment of continuous processing for manufacturing of biotherapeutics	27
Reshaping cell line development and CMC strategy for fast responses to pandemic outbreak	23
Identification and characterization of a residual host cell protein hexosaminidase B associated with N‐glycan degradation during the stability study of a therapeutic recombinant monoclonal anti	23
Exploring the potential of machine learning for more efficient development and production of biopharmaceuticals	23
Synthesis of a novel nanocomposite containing chitosan as a three‐dimensional printed wound dressing technique: Emphasis on gene expression	22
Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects	21
The effect of biosynthesized selenium nanoparticles on the expression of CYP51A and HSP90 antifungal resistance genes in Aspergillus fumigatus and Aspergi	21
Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions	21
Process and operations strategies to enable global access to antibody therapies	20
Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends	19
Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase‐mediated cassette exchange	19
Anti‐epithelial cell adhesion molecule RNA aptamer‐conjugated liposomal doxorubicin as an efficient targeted therapy in mice bearing colon carcinoma tumor model	18
In silico process characterization for biopharmaceutical development following the quality by design concept	18
Using microalgae for remediation of crude petroleum oil–water emulsions	18
Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process	18
Devices and techniques used to obtain and analyze three‐dimensional cell cultures	17
Nanoparticles in cancer immunotherapies: An innovative strategy	16
Rapid intensification of an established CHO cell fed‐batch process	15

Synthetic biology in biofilms: Tools, challenges, and opportunities	14
Immobilized enzymes as potent antibiofilm agent	14
Adapting virus filtration to enable intensified and continuous monoclonal antibody processing	14
Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations	13
Chemistry of lignin and hemicellulose structures interacts with hydrothermal pretreatment severity and affects cellulose conversion	13
Continuous CTC separation through a DEP‐based contraction–expansion inertial microfluidic channel	13
Immunoliposomes bearing lymphocyte activation gene 3 fusion protein and P5 peptide: A novel vaccine for breast cancer	13
Differential responses in EPA and fucoxanthin production by the marine diatom Stauroneis sp. under varying cultivation conditions	13
Metabolic trends of Chinese hamster ovary cells in biopharmaceutical production under batch and fed‐batch conditions	13
Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity	12
Hydrolysis of lignocellulose by anaerobic fungi produces free sugars and organic acids for two‐stage fine chemical production with Kluyveromyces marxianus	12
PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing	12
Metabolic engineering of Yarrowia lipolytica for the production of isoprene	12
Induced pluripotent stem cells can utilize lactate as a metabolic substrate to support proliferation	11
Metabolic profiling of Chinese hamster ovary cell cultures at different working volumes and agitation speeds using spin tube reactors	11
Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems	11
Effects of variable domain orientation on anti‐HER2 single‐chain variable fragment antibody expressed in the Escherichia coli cytoplasm	11
Yeast cells for encapsulation of bioactive compounds in food products: A review	11
High‐throughput and automation advances for accelerating single‐cell cloning, monoclonality and early phase clone screening steps in mammalian cell line development for biologics production	11
Protection of human induced pluripotent stem cells against shear stress in suspension culture by Bingham plastic fluid	11
Ionic liquid‐based in situ product removal design exemplified for an acetone–butanol–ethanol fermentation	10
Development of virus‐like particles‐based vaccines against coronaviruses	10
Hypoxia preconditioned mesenchymal stem cell‐derived exosomes induce ex vivo expansion of umbilical cord blood hematopoietic stem cells CD133+ by stimulation of Notch signaling pathway	10
Molecularly imprinted spongy columns for Angiotensin(II) recognition from human serum	10
Development of targeted gene delivery system based on liposome and PAMAM dendrimer functionalized with hyaluronic acid and TAT peptide: In vitro and in vivo studies	10
The function of chitosan/agarose biopolymer on Fe₂O₃ nanoparticles and evaluation of their effects on MCF‐7 breast cancer cell line and expression of B	10
A rapid novel strategy for screening of antibody phage libraries for production, purification, and functional characterization of amber stop codons containing single‐chain antibody fragments	10
CHOK1SV GS‐KO SSIexpression system: A combination of theFer1L4locus and glutamine synthetase selection	9
Immobilization of urease enzyme on chitosan/polyvinyl alcohol electrospun nanofibers	9
Bax and Bak knockout apoptosis‐resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed‐batch culture process	9
α‐Acetolactate decarboxylase immobilized in chitosan: A highly stable biocatalyst to prevent off‐flavor in beer	9
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity eff	9
A mechanistic model to account for the Donnan and volume exclusion effects in ultrafiltration/diafiltration process of protein formulations	9
Transcriptomic features reveal molecular signatures associated with recombinant adeno‐associated virus production in HEK293 cells	9
Microfluidic chip‐based single‐cell cloning to accelerate biologic production timelines	8
Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous	8
Comprehensive studies on building a scalable downstream process for mRNAs to enable mRNA therapeutics	8
Characterization of Chinese hamster ovary cell culture feed media precipitate	8
Production of biodiesel by Burkholderia cepacia lipase as a function of process parameters	8
Biophysical analysis of SARS‐CoV‐2 transmission and theranostic development via N protein computational characterization	8
Larvicidal potential of cell wall degrading enzymes from Trichoderma asperellum against Aedes aegypti (Diptera: Culicidae)	8
X‐ray sterilization of biopharmaceutical manufacturing equipment—Extractables profile of a film material and copolyester Tritan™ compared to gamma irradiation	8
Evaluation of lentiviral vector stability and development of ion exchange purification processes	8
Rheology of enzyme liquefied corn stover slurries: The effect of solids concentration on yielding and flow behavior	8
Transferability of miRNA‐technology to bioprocessing: Influence of cultivation mode and media	8
The pandemic and resilience for the future: AccBio 2021	8
Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy	7
Current challenges and recent advances on the path towards continuous biomanufacturing	7
Analytical characterization of host‐cell‐protein‐rich aggregates in monoclonal antibody solutions	7
Biophysical properties of tense quaternary state polymerized human hemoglobins bracketed between 500 kDa and 0.2 μm in size	7

Safety risk management for low molecular weight process‐related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveragi	7
Mechanistic modeling, simulation, and optimization of mixed‐mode chromatography for an antibody polishing step	7
Improvement of the efficiency and quality in developing a new CHO host cell line	7
Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification	7
Optimization and feedback control system of dilution rate for 1,3‐propanediol in two‐stage fermentation: A theoretical study	7
Prebiotic peptides, their formation, fermentation in the gut, and health implications	7
Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes	7
High‐capacity multimodal anion‐exchange membranes for polishing of therapeutic proteins	7
Effect of filtrate flux and process disruptions on virus retention by a relatively homogeneous virus removal membrane	7
Accelerated CMC workflows to enable speed to clinic in the COVID‐19 era: A multi‐company view from the biopharmaceutical industry	7
Smart process development: Application of machine‐learning and integrated process modeling for inclusion body purification processes	7
Effect of nitrate feeding strategies on lipid and biomass productivities in fed‐batch cultures of Nannochloropsis gaditana	6
Impact of X‐ray irradiation as an equivalent alternative to gamma for sterilization of single‐use bioprocessing polymers	6
Evaluation of the efficiency of modified PAMAM dendrimer with low molecular weight protamine peptide to deliver IL ‐12 plasmid int	6
Applications of flow cytometry sorting in the pharmaceutical industry: A review	6
Identification of compendial nonionic detergents for the replacement of Triton X‐100 in bioprocessing	6
Microbioreactor (micro‐Matrix) potential in aerobic and anaerobic conditions with different industrially relevant microbial strains	6
Structure and binding ability of self‐assembled α‐lactalbumin protein nanotubular gels	6
Effect of iron addition on mAb productivity and oxidative stress in Chinese hamster ovary culture	6
Modeling flux in tangential flow filtration using a reverse asymmetric membrane for Chinese hamster ovary cell clarification	6
Semicontinuous system for the production of recombinant mCherry protein in Chlamydomonas reinhardtii	6
Polyunsaturated fatty acids production by solid‐state fermentation on polyurethane foam by Mortierella alpina	6
The impact of temozolomide and lonafarnib on the stemness marker expression of glioblastoma cells in multicellular spheroids	6
Identification and classification of host cell proteins during biopharmaceutical process development	6
Self‐assembling protein nanocages for modular enzyme assembly by orthogonal bioconjugation	6
High‐yield recombinant adeno‐associated viral vector production by multivariate optimization of bioprocess and transfection conditions	6
Probing morphological, genetic and metabolomic changes of in vitro embryo development in a microfluidic device	5
Modulation of high mannose levels in N‐linked glycosylation through cell culture process conditions to increase antibody‐dependent cell‐mediated cytotoxicity activity for an antibody biosimilar	5
Scale‐up issues during sterile filtration of glycoconjugate vaccines	5
Application of Ambr15 system for simulation of entire SARS‐CoV‐2 vaccine production process involving macrocarriers	5
Control strategy for biopharmaceutical production by model predictive control	5
Impact of different trace elements on metabolic routes during heterotrophic growth of C. ljungdahlii investigated through online measurement of the carbon dioxide transfer rate	5
Preparation and characterization of poly (lactic‐co‐glycolic acid) nanofibers containing simvastatin coated with hyaluronic acid for using in periodontal tissue engineering	5
Impact of iron raw materials and their impurities onCHOmetabolism and recombinant protein product quality	5
Evaluating multiproduct chromatography Protein A resin reuse for monoclonal antibodies in biopharmaceutical manufacturing	5
Exometabolome profiling reveals activation of the carnitine buffering pathway in fed‐batch cultures ofCHOcells co‐fed with glucose and lactic acid	5
Bio‐based composite granules with simultaneous biocontrol and phosphorus fertilization roles: Outcomes from a lab‐scale in vitro assessment	5
Quantification of glycated IgG in CHO supernatants: A practical approach	5
A novel NCI‐H69V small cell lung cancer functional mini‐tumor model for future treatment screening applications	5
Application of mesenchymal stem cells in regenerative medicine: A new approach in modern medical science	5
Determination of protein concentration in downstream biomanufacturing processes by in‐line index of refraction	5
Genetically engineered neural stem cells (NSCs) therapy for neurological diseases; state‐of‐the‐art	5
Dentin regeneration based on tooth tissue engineering: A review	5
Real‐time online monitoring of insect cell proliferation and baculovirus infection using digital differential holographic microscopy and machine learning	5
Effect of particle size distribution on filtration performance of cell culture medium	5
Transgenic plants expressing a Clostridium difficile spore antigen as an approach to develop low‐cost oral vaccines	5
Unraveling the potential and constraints associated with corn steep liquor as a nutrient source for industrial fermentations	5
Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis	5