Bone

Article	Citations
The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update	121
Bone regeneration is mediated by macrophage extracellular vesicles	96
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton	84
Re-thinking the bone remodeling cycle mechanism and the origin of bone loss	77
The role of gut microbiota in bone homeostasis	77
Circular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head	73
The role of bone morphogenetic protein signaling in vascular calcification	70
Deep learning of lumbar spine X-ray for osteopenia and osteoporosis screening: A multicenter retrospective cohort study	67
Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors	65
The development, patterning and evolution of neural crest cell differentiation into cartilage and bone	61
Epidemiology of bone metastases	60
The effect of exercise intensity on bone in postmenopausal women (part 2): A meta-analysis	57
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification	56
Discovery of bone morphogenetic proteins – A historical perspective	51
Epigenetic and transcriptional regulation of osteoclast differentiation	51
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development	49
Raman and Fourier transform infrared imaging for characterization of bone material properties	49
Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction	45
Treatment of postmenopausal osteoporosis with bone-forming and antiresorptive treatments: Combined and sequential approaches	44
Notch and the regulation of osteoclast differentiation and function	43
Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice	43
The role of microRNAs in bone development	43
Recent approaches towards bone tissue engineering	42
Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension	41
Zoledronate	41

A randomized pilot study using calcitriol in hospitalized COVID-19 patients	41
Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management	41
RANKL biology	40
Growth plate skeletal stem cells and their transition from cartilage to bone	39
PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis	39
Risk of major osteoporotic fracture after first, second and third fracture in Swedish women aged 50 years and older	39
Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study	37
Circulating miRNAs in bone health and disease	36
The Wnt pathway: An important control mechanism in bone's response to mechanical loading	36
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use	36
Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells	36
Structural perspective of BMP ligands and signaling	35
Bone morphogenic proteins in iron homeostasis	35
Crosstalk between skeletal and neural tissues is critical for skeletal health	35
BMP signalling in a mechanical context – Implications for bone biology	35
From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis	34
Effects of prior osteoporosis treatment on early treatment response of romosozumab in patients with postmenopausal osteoporosis	34
Identification of PIEZO1 polymorphisms for human bone mineral density	33
Wnt modulation in bone healing	32
Novel therapeutic approaches for the treatment of achondroplasia	31
Adjuvant therapies for MRONJ: A systematic review	31
Bisphosphonates impair the onset of bone formation at remodeling sites	31
Lifetime impact of achondroplasia: Current evidence and perspectives on the natural history	30
Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase	30
Post-antibiotic gut dysbiosis-induced trabecular bone loss is dependent on lymphocytes	30
Bone mineral density and osteoporosis in relation to all-cause and cause-specific mortality in NHANES: A population-based cohort study	30
Biological stenciling of mineralization in the skeleton: Local enzymatic removal of inhibitors in the extracellular matrix	29
Scaffold-guided bone regeneration in large volume tibial segmental defects	29
Risk factors for vertebral fractures and bone loss after denosumab discontinuation: A real-world observational study	29
Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis	29
Bariatric surgery and skeletal health: A narrative review and position statement for management by the European Calcified Tissue Society (ECTS)	29
Nestin-GFP transgene labels skeletal progenitors in the periosteum	29
Targeting anti-cancer agents to bone using bisphosphonates	29
Extracellular pyrophosphate: The body's “water softener”	29
Clinical efficiency of epigenetic drugs therapy in bone malignancies	29
History of alendronate	28
Role of Prx1-expressing skeletal cells and Prx1-expression in fracture repair	28
Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context	28
Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice	28
Extracellular vesicles secreted from mouse muscle cells suppress osteoclast formation: Roles of mitochondrial energy metabolism	28
Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model	28
Osteoclast-mediated bone loss observed in a COVID-19 mouse model	28
Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis	28
Multiscale finite element modeling of mechanical strains and fluid flow in osteocyte lacunocanalicular system	28
Individuals with type 2 diabetes mellitus show dimorphic and heterogeneous patterns of loss in femoral bone quality	28
The multifaced role of HtrA1 in the development of joint and skeletal disorders	28
The cardiovascular disease burden of non-traumatic fractures for adults with and without cerebral palsy	28
The treatment gap: The missed opportunities for osteoporosis therapy	27
The effect of exercise intensity on bone in postmenopausal women (part 1): A systematic review	27
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency	26

The three-year effect of a single zoledronate infusion on bone mineral density and bone turnover markers following denosumab discontinuation in women with postmenopausal osteoporosis	26
Two adipocytokines, leptin and adiponectin, independently predict osteoporotic fracture risk at different bone sites in postmenopausal women	26
Regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by semaphorin 3A	26
Biological activity is not suppressed in mid-shaft stress fracture of the bowed femoral shaft unlike in “typical” atypical subtrochanteric femoral fracture: A proposed theory of atypical femoral fract	26
Fibrodysplasia ossificans progressiva (FOP): A disorder of osteochondrogenesis	26
Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery	26
Challenges in the management of tumor-induced osteomalacia (TIO)	26
Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: The LIFT	26
Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration	25
Lipid metabolism in sarcopenia	25
Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment	25
Early extrapulmonary prognostic features in chest computed tomography in COVID-19 pneumonia: Bone mineral density is a relevant predictor for the clinical outcome - A multicenter feasibility study	25
Multiple pharmacological inhibitors targeting the epigenetic suppressor enhancer of zeste homolog 2 (Ezh2) accelerate osteoblast differentiation	25
The origins and formation of bone-resorbing osteoclasts	25
Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)	25
Bone outcomes following sleeve gastrectomy in adolescents and young adults with obesity versus non-surgical controls	25
Selenium status is independently related to bone mineral density, FRAX score, and bone fracture history: NHANES, 2013 to 2014	25
The role of endogenous GIP and GLP-1 in postprandial bone homeostasis	24
MiR-1-3p regulates the differentiation of mesenchymal stem cells to prevent osteoporosis by targeting secreted frizzled-related protein 1	24
Primary cilia act as microgravity sensors by depolymerizing microtubules to inhibit osteoblastic differentiation and mineralization	24
MRI-based assessment of proximal femur strength compared to mechanical testing	24
The cytoskeleton and connected elements in bone cell mechano-transduction	24
Activin A does not drive post-traumatic heterotopic ossification	24
Pulsed electromagnetic fields modify the adverse effects of glucocorticoids on bone architecture, bone strength and porous implant osseointegration by rescuing bone-anabolic actions	24
Loading-driven PI3K/Akt signaling and erythropoiesis enhanced angiogenesis and osteogenesis in a postmenopausal osteoporosis mouse model	24
Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association	24
Abnormal macrophage polarization impedes the healing of diabetes-associated tooth sockets	23
Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair	23
Assessing causal relationship from gut microbiota to heel bone mineral density	23
TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations	23
Consumption of nutrients and insulin resistance suppress markers of bone turnover in subjects with abdominal obesity	23
The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging	23
Bisphosphonates and lifespan	23
Cholesterol metabolism related genes in osteoarthritis	23
Correlation between 18F-Sodium Fluoride positron emission tomography and bone histomorphometry in dialysis patients	23
Tetracyclines and bone: Unclear actions with potentially lasting effects	23
Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)	23
1,25(OH)2D3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function	22
MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells	22
An understanding of bone pain: A narrative review	22
PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss	22
Multiscale modeling of bone tissue mechanobiology	22
What do we know about bone morphogenetic proteins and osteochondroprogenitors in inflammatory conditions?	22
Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization	22
Learning from BMPs and their biophysical extracellular matrix microenvironment for biomaterial design	22
Impact of magnesium on bone health in older adults: A systematic review and meta-analysis	22
Ethnic and gender-specific incidence rates for hip fractures in South Africa: A multi-centre study	22
miR-99a in bone homeostasis: Regulating osteogenic lineage commitment and osteoclast differentiation	22
Association between serum FGF21 level and sarcopenia in older adults	22
The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study	22
Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep	22
Conventional finite element models estimate the strength of metastatic human vertebrae despite alterations of the bone's tissue and structure	22
Amino acid metabolism and autophagy in skeletal development and homeostasis	22
CDllb+ targeted depletion of macrophages negatively affects bone fracture healing	22
Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/β-catenin signaling pathway	21
A cell-based combination product for the repair of large bone defects	21
High bone mass from mutation of low-density lipoprotein receptor-related protein 6 (LRP6)	21
Cortical bone mapping improves finite element strain prediction accuracy at the proximal femur	21
Wireless sensor enables longitudinal monitoring of regenerative niche mechanics during rehabilitation that enhance bone repair	21
Bacteroides vulgatus diminishes colonic microbiota dysbiosis ameliorating lumbar bone loss in ovariectomized mice	21
A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice	21
Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model	21
Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks	20
A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures	20
Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice	20
Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?	20
Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization im	20
Asian ethnicity is associated with atypical femur fractures in an Australian population study	20
History of etidronate	20
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer	20
Impact microindentation in men with impaired fasting glucose and type 2 diabetes	20
Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome	20
Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats	20
Osteocalcin and its forms respond similarly to exercise in males and females	20
Increasing fluoride content deteriorates rat bone mechanical properties	20
Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA	19
Skeletal dynamics of Down syndrome: A developing perspective	19
Fractures after kidney transplantation: Incidence, predictors, and association with mortality	19
Critical periods of bone health across the lifespan for individuals with cerebral palsy: Informing clinical guidelines for fracture prevention and monitoring	19
Large osteocyte lacunae in iliac crest infantile bone are not associated with impaired mineral distribution or signs of osteocytic osteolysis	19

MicroRNAs regulating TGFβ and BMP signaling in the osteoblast lineage	19
The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review	19
Glutamine metabolite α-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation	19
Wnt signaling in chondroprogenitors during long bone development and growth	19
Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis	19
“The use of bisphosphonates to treat skeletal complications in solid tumours”	19
Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability	19
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography	19
Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice	19
Intravital optoacoustic and ultrasound bio-microscopy reveal radiation-inhibited skull angiogenesis	18
Co-aligned chondrocytes: Zonal morphological variation and structured arrangement of cell lacunae in tessellated cartilage	18
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier	18
Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis	18
Mind the gap: Incidence of osteoporosis treatment after an osteoporotic fracture – results of the Austrian branch of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUR	18
Type 2 innate lymphoid cells inhibit the differentiation of osteoclasts and protect from ovariectomy-induced bone loss	18
Differential risk of fracture attributable to type 2 diabetes mellitus according to skeletal site	18
ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages	18
WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade	18
miRNAs in osteoclast biology	18
Glucose variability and low bone turnover in people with type 2 diabetes	18
Inhibition of the mitochondrial permeability transition improves bone fracture repair	18
Bisphosphonates for the treatment of fibrous dysplasia of bone	18
Persistent low-normal bone mineral density in adolescent idiopathic scoliosis with different curve severity: A longitudinal study from presentation to beyond skeletal maturity and peak bone mass	18
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma	18
The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p	18
A search for apatite crystals in the gap zone of collagen fibrils in bone using dark-field illumination	18
Age and sex effects on FGF23-mediated response to mild phosphate challenge	18
Incidence of and risk for osteonecrosis of the jaw in Korean osteoporosis patients treated with bisphosphonates: A nationwide cohort-study	18
MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora	17
The epiphyseal secondary ossification center: Evolution, development and function	17
Bone mineral density in Anorexia Nervosa versus Avoidant Restrictive Food Intake Disorder	17
Gain-of-function variants and overexpression of RUNX2 in patients with nonsyndromic midline craniosynostosis	17
Vascular calcification relationship to vascular biomarkers and bone metabolism in advanced chronic kidney disease	17
Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia	17
A deep learning system for automated, multi-modality 2D segmentation of vertebral bodies and intervertebral discs	17
Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs	17
Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review)	17
Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic	17
Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations	17
Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength	17
From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies	17
Musculoskeletal morbidity following spinal cord injury: A longitudinal cohort study of privately-insured beneficiaries	17
Using confocal imaging approaches to understand the structure and function of osteocytes and the lacunocanalicular network	17
A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss	17
The effect of different training frequency on bone mineral density in older adults. A comparative systematic review and meta-analysis	17
Bisphosphonates in veterinary medicine: The new horizon for use	17
Conditional deletion of Adrb2 in mesenchymal stem cells attenuates osteoarthritis-like defects in temporomandibular joint	17
Bisphosphonates and the risk of atypical femur fractures	17
The effect of frailty on outcomes of surgically treated hip fractures in older people	16
Practical guidance for the use of bisphosphonates in osteoporosis	16
Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage	16
Reference intervals in Danish children and adolescents for bone turnover markers carboxy-terminal cross-linked telopeptide of type I collagen (β-CTX), pro-collagen type I N-terminal propeptide (PINP),	16
High resolution imaging in bone tissue research-review	16
Circulating serum microRNAs including senescent miR-31-5p are associated with incident fragility fractures in older postmenopausal women with type 2 diabetes mellitus	16
Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling	16
Cytokine-mediated immunomodulation of osteoclastogenesis	16
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects	16
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) due to ENPP1-deficiency	16
Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry	16
Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank	16
Osteoblastic Wnt1 regulates periosteal bone formation in adult mice	16
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis	16
Trabecular bone score and transilial bone trabecular histomorphometry in type 1 diabetes and healthy controls	15
Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators	15
Ex vivo regional gene therapy with human adipose-derived stem cells for bone repair	15
Secreted BMP antagonists and their role in cancer and bone metastases	15
Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral	15
Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness	15
The challenge of long-term adherence: The role of bone turnover markers in monitoring bisphosphonate treatment of osteoporosis	15
Tunnels in the rock: Dynamics of osteocyte morphogenesis	15
Bisphosphonates in the management of Paget's disease	15
Post-translational modifications in collagen type I of bone in a mouse model of aging	15
G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development	15
Major fractures after initiation of dialysis: Incidence, predictors and association with mortality	15
Relevant genetic variants are common in women with pregnancy and lactation-associated osteoporosis (PLO) and predispose to more severe clinical manifestations	15
MicroRNA function in craniofacial bone formation, regeneration and repair	15
Burosumab treatment for fibrous dysplasia	15
Treatment of osteoporosis after hip fracture is associated with lower all-cause mortality: A nationwide population study	15
Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use	15
Methodological quality of systematic reviews on treatments for osteoporosis: A cross-sectional study	15
“Which skeletal imaging modality is best for assessing bone health in children and young adults compared to DXA? A systematic review and meta-analysis”	15
Bone adaptation to mechanical loading in mice is affected by circadian rhythms	15
Evaluation of patient tissue selection methods for deriving equivalent density calibration for femoral bone quantitative CT analyses	15
Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness	15
ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures	15
Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance	15
Favorable skeletal benefit/risk of long-term denosumab therapy: A virtual-twin analysis of fractures prevented relative to skeletal safety events observed	14
Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations	14
Serum vitamin K1 (phylloquinone) is associated with fracture risk and hip strength in post-menopausal osteoporosis: A cross-sectional study	14
The role of miR-150 regulates bone cell differentiation and function	14
Epidemiology and the economic burden of pediatric fractures in China: A retrospective study of 14,141 fractures	14
On the pharmacological evaluation of bisphosphonates in humans	14
Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris)	14
Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility	14
Aerobic and resistance training improve alveolar bone quality and interferes with bone-remodeling during orthodontic tooth movement in mice	14