Bone

Article	Citations
Bone regeneration is mediated by macrophage extracellular vesicles	109
Re-thinking the bone remodeling cycle mechanism and the origin of bone loss	88
Deep learning of lumbar spine X-ray for osteopenia and osteoporosis screening: A multicenter retrospective cohort study	84
The role of bone morphogenetic protein signaling in vascular calcification	79
Epidemiology of bone metastases	74
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification	68
The effect of exercise intensity on bone in postmenopausal women (part 2): A meta-analysis	66
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development	59
RANKL biology	58
Recent approaches towards bone tissue engineering	55
Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction	52
Discovery of bone morphogenetic proteins – A historical perspective	52
A randomized pilot study using calcitriol in hospitalized COVID-19 patients	51
Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice	49
Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management	49
The Wnt pathway: An important control mechanism in bone's response to mechanical loading	46
The role of microRNAs in bone development	46
Lipid metabolism in sarcopenia	45
PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis	44
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use	43
Effects of prior osteoporosis treatment on early treatment response of romosozumab in patients with postmenopausal osteoporosis	41
Tetracyclines and bone: Unclear actions with potentially lasting effects	40
Structural perspective of BMP ligands and signaling	40
From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis	40
Lifetime impact of achondroplasia: Current evidence and perspectives on the natural history	39

Circulating miRNAs in bone health and disease	39
Bone mineral density and osteoporosis in relation to all-cause and cause-specific mortality in NHANES: A population-based cohort study	38
Crosstalk between skeletal and neural tissues is critical for skeletal health	38
Bisphosphonates impair the onset of bone formation at remodeling sites	37
Novel therapeutic approaches for the treatment of achondroplasia	37
Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context	37
The origins and formation of bone-resorbing osteoclasts	36
Adjuvant therapies for MRONJ: A systematic review	36
The multifaced role of HtrA1 in the development of joint and skeletal disorders	36
Bariatric surgery and skeletal health: A narrative review and position statement for management by the European Calcified Tissue Society (ECTS)	35
The treatment gap: The missed opportunities for osteoporosis therapy	35
Loading-driven PI3K/Akt signaling and erythropoiesis enhanced angiogenesis and osteogenesis in a postmenopausal osteoporosis mouse model	34
Scaffold-guided bone regeneration in large volume tibial segmental defects	34
Clinical efficiency of epigenetic drugs therapy in bone malignancies	32
The role of endogenous GIP and GLP-1 in postprandial bone homeostasis	32
Osteoclast-mediated bone loss observed in a COVID-19 mouse model	32
Risk factors for vertebral fractures and bone loss after denosumab discontinuation: A real-world observational study	31
Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis	31
Challenges in the management of tumor-induced osteomalacia (TIO)	31
The effect of exercise intensity on bone in postmenopausal women (part 1): A systematic review	30
Individuals with type 2 diabetes mellitus show dimorphic and heterogeneous patterns of loss in femoral bone quality	30
The cytoskeleton and connected elements in bone cell mechano-transduction	30
Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery	30
Abnormal macrophage polarization impedes the healing of diabetes-associated tooth sockets	30
Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)	30
Multiscale modeling of bone tissue mechanobiology	30
PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss	29
Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?	29
Impact of magnesium on bone health in older adults: A systematic review and meta-analysis	29
Fibrodysplasia ossificans progressiva (FOP): A disorder of osteochondrogenesis	29
Bisphosphonates and lifespan	28
Association between serum FGF21 level and sarcopenia in older adults	28
Multiple pharmacological inhibitors targeting the epigenetic suppressor enhancer of zeste homolog 2 (Ezh2) accelerate osteoblast differentiation	28
Cholesterol metabolism related genes in osteoarthritis	27
Amino acid metabolism and autophagy in skeletal development and homeostasis	27
Early extrapulmonary prognostic features in chest computed tomography in COVID-19 pneumonia: Bone mineral density is a relevant predictor for the clinical outcome - A multicenter feasibility study	27
Bacteroides vulgatus diminishes colonic microbiota dysbiosis ameliorating lumbar bone loss in ovariectomized mice	27
Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment	27
Conventional finite element models estimate the strength of metastatic human vertebrae despite alterations of the bone's tissue and structure	26
Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association	26
Selenium status is independently related to bone mineral density, FRAX score, and bone fracture history: NHANES, 2013 to 2014	26
Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair	26
Bisphosphonates for the treatment of fibrous dysplasia of bone	26
Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)	25
Bisphosphonates in veterinary medicine: The new horizon for use	25
1,25(OH)2D3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function	25
ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages	25
The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study	25
MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells	25
Assessing causal relationship from gut microbiota to heel bone mineral density	25

Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration	25
Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization	25
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography	24
From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies	24
Osteocalcin and its forms respond similarly to exercise in males and females	24
The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review	24
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer	24
Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis	23
Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility	23
A deep learning system for automated, multi-modality 2D segmentation of vertebral bodies and intervertebral discs	23
Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage	23
Glucose variability and low bone turnover in people with type 2 diabetes	23
Glutamine metabolite α-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation	23
Fractures after kidney transplantation: Incidence, predictors, and association with mortality	23
Learning from BMPs and their biophysical extracellular matrix microenvironment for biomaterial design	23
MicroRNAs regulating TGFβ and BMP signaling in the osteoblast lineage	22
Bisphosphonates and the risk of atypical femur fractures	22
Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA	22
Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia	22
Impact microindentation in men with impaired fasting glucose and type 2 diabetes	21
A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures	21
Mind the gap: Incidence of osteoporosis treatment after an osteoporotic fracture – results of the Austrian branch of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUR	21
The effect of different training frequency on bone mineral density in older adults. A comparative systematic review and meta-analysis	21
Musculoskeletal morbidity following spinal cord injury: A longitudinal cohort study of privately-insured beneficiaries	21
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier	21
A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss	21
“The use of bisphosphonates to treat skeletal complications in solid tumours”	21
Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice	21
High bone mass from mutation of low-density lipoprotein receptor-related protein 6 (LRP6)	21
Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia	20
Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis	20
miRNAs in osteoclast biology	20
The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p	20
Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism	20
Age and sex effects on FGF23-mediated response to mild phosphate challenge	20
Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice	20
WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade	20
The epiphyseal secondary ossification center: Evolution, development and function	20
High resolution imaging in bone tissue research-review	20
Evaluation of patient tissue selection methods for deriving equivalent density calibration for femoral bone quantitative CT analyses	19
Reference intervals in Danish children and adolescents for bone turnover markers carboxy-terminal cross-linked telopeptide of type I collagen (β-CTX), pro-collagen type I N-terminal propeptide (PINP),	19
Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic	19
Iron overload induced osteocytes apoptosis and led to bone loss in Hepcidin−/− mice through increasing sclerostin and RANKL/OPG	19
Critical periods of bone health across the lifespan for individuals with cerebral palsy: Informing clinical guidelines for fracture prevention and monitoring	19
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) due to ENPP1-deficiency	19
Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability	19
Tunnels in the rock: Dynamics of osteocyte morphogenesis	19
Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations	18
Relevant genetic variants are common in women with pregnancy and lactation-associated osteoporosis (PLO) and predispose to more severe clinical manifestations	18
MicroRNA function in craniofacial bone formation, regeneration and repair	18
MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora	18
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects	18
“Which skeletal imaging modality is best for assessing bone health in children and young adults compared to DXA? A systematic review and meta-analysis”	18
Bone adaptation to mechanical loading in mice is affected by circadian rhythms	18
Vascular calcification relationship to vascular biomarkers and bone metabolism in advanced chronic kidney disease	18
Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia	18
Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading	18
Cytokine-mediated immunomodulation of osteoclastogenesis	18
Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review)	18
Incidence of and risk for osteonecrosis of the jaw in Korean osteoporosis patients treated with bisphosphonates: A nationwide cohort-study	18
Differential risk of fracture attributable to type 2 diabetes mellitus according to skeletal site	18
Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling	18
Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank	18
Burosumab treatment for fibrous dysplasia	18
Effects of recreational team handball on bone health, postural balance and body composition in inactive postmenopausal women — A randomised controlled trial	18
Mechanical loading and parathyroid hormone effects and synergism in bone vary by site and modeling/remodeling regime	18
Post-translational modifications in collagen type I of bone in a mouse model of aging	17
Epidemiology and the economic burden of pediatric fractures in China: A retrospective study of 14,141 fractures	17
Dendritic cells development into osteoclast-type APCs by 4T1 breast tumor T cells milieu boost bone consumption	17
Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness	17
Machine learning for automated abdominal aortic calcification scoring of DXA vertebral fracture assessment images: A pilot study	17
Pathogenesis of acquired heterotopic ossification: Risk factors, cellular mechanisms, and therapeutic implications	17
Reciprocal effect of microRNA-224 on osteogenesis and adipogenesis in steroid-induced osteonecrosis of the femoral head	17
Sirtuin function and metabolism: Role in pancreas, liver, and adipose tissue and their crosstalk impacting bone homeostasis	17
At the nuclear envelope of bone mechanobiology	17
Electrical stimulation of hindlimb skeletal muscle has beneficial effects on sublesional bone in a rat model of spinal cord injury	17
Feasibility of a generalized convolutional neural network for automated identification of vertebral compression fractures: The Manitoba Bone Mineral Density Registry	17
A comparison of alendronate to varying magnitude PEMF in mitigating bone loss and altering bone remodeling in skeletally mature osteoporotic rats	17
Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss	17
Mechanically-regulated bone repair	17

Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance	17
Bisphosphonates as a treatment modality in osteoarthritis	16
Patients with abnormal microarchitecture have an increased risk of early complications after spinal fusion surgery	16
Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness	16
The role of tendon derived stem/progenitor cells and extracellular matrix components in the bone tendon junction repair	16
Diet-derived fruit and vegetable metabolites show sex-specific inverse relationships to osteoporosis status	16
Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use	16
NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy	16
Inhibition of IL-6 in the treatment of fibrous dysplasia of bone: The randomized double-blind placebo-controlled TOCIDYS trial	16
Health service use pathways associated with recovery of quality of life at 12-months for individual fracture sites: Analyses of the International Costs and Utilities Related to Osteoporotic fractures	16
Circulating serum microRNAs including senescent miR-31-5p are associated with incident fragility fractures in older postmenopausal women with type 2 diabetes mellitus	16
Effects of zoledronate on bone mineral density and bone turnover after long-term denosumab therapy: Observations in a real-world setting	16
Assessing bone maturity: Compositional and mechanical properties of rib cortical bone at different ages	16
Osteoblastic Wnt1 regulates periosteal bone formation in adult mice	16
Fractures in type 2 diabetes confer excess mortality: The Dubbo osteoporosis epidemiology study	16
Development of a manufacturer-independent convolutional neural network for the automated identification of vertebral compression fractures in vertebral fracture assessment images using active learning	16
Metabolomics-driven of relationships among kidney, bone marrow and bone of rats with postmenopausal osteoporosis	16
Odontoblast differentiation is regulated by an interplay between primary cilia and the canonical Wnt pathway	16
Treatment of osteoporosis after hip fracture is associated with lower all-cause mortality: A nationwide population study	16
Low bone mass resulting from impaired estrogen signaling in bone increases severity of load-induced osteoarthritis in female mice	16
MicroRNAs and osteocytes	16
Denosumab versus alendronate in long-term glucocorticoid users: A 12-month randomized controlled trial	16
Muscle strength and physical performance contribute to and improve fracture risk prediction in older people: A narrative review	15
Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral	15
Osteogenesis imperfecta in children	15
The role of miR-150 regulates bone cell differentiation and function	15
Clodronate	15
Lactation alters fluid flow and solute transport in maternal skeleton: A multiscale modeling study on the effects of microstructural changes and loading frequency	15
Finite element derived femoral strength is a better predictor of hip fracture risk than aBMD in the AGES Reykjavik study cohort	15
Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties	15
Intra-articular injection of a novel Wnt pathway inhibitor, SM04690, upregulates Wnt16 expression and reduces disease progression in temporomandibular joint osteoarthritis	15
Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris)	15
Mechanisms of bone resorption	15
RASopathies: The musculoskeletal consequences and their etiology and pathogenesis	15
Coupling induction of osteogenesis and type H vessels by pulsed electromagnetic fields in ovariectomy-induced osteoporosis in mice	15
GATA4 regulates mesenchymal stem cells via direct transcriptional regulation of the WNT signalosome	15
Association of higher bone turnover with risk of curve progression in adolescent idiopathic scoliosis	15
Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study	15
Reorganization of the osteocyte lacuno-canalicular network characteristics in tumor sites of an immunocompetent murine model of osteotropic cancers	15
Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations	15
Differences in the microarchitectural features of the lateral collapsed lesion between osteonecrosis and subchondral insufficiency fracture of the femoral head	14
The coupling of reduced type H vessels with unloading-induced bone loss and the protection role of Panax quinquefolium saponin in the male mice	14
Large-scale osteocyte lacunar morphological analysis of transiliac bone in normal and osteoporotic premenopausal women	14
Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice	14
Persistence with osteoporosis treatment in patients from the Lille University Hospital Fracture Liaison Service	14
Bisphosphonates and breast cancer – From cautious palliation to saving lives	14
AKAP2 overexpression modulates growth plate chondrocyte functions through ERK1/2 signaling	14
Reference values for bone mineral density in healthy Mexican children and adolescents	14
Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis	14
Frequent administration of abaloparatide shows greater gains in bone anabolic window and bone mineral density in mice: A comparison with teriparatide	14
Dominant osteogenesis imperfecta with low bone turnover caused by a heterozygous SP7 variant	14
Diabetes impairs fracture healing through disruption of cilia formation in osteoblasts	14
Serum vitamin K1 (phylloquinone) is associated with fracture risk and hip strength in post-menopausal osteoporosis: A cross-sectional study	14
Validation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH)	14
PTX3 promotes osteogenic differentiation by triggering HA/CD44/FAK/AKT positive feedback loop in an inflammatory environment	14
Impaired physical function and evaluation of quality of life in normocalcemic and hypercalcemic primary hyperparathyroidism	14
Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis	14
The bone strain index predicts fragility fractures. The OFELY study	14
Changes in bone mass associated with obesity and weight loss in humans: Applicability of animal models	14
Multiple versus solitary giant cell lesions of the jaw: Similar or distinct entities?	14
Bone tissue material composition is compromised in premenopausal women with Type 2 diabetes	14
Randomized controlled trial of daily teriparatide, weekly high-dose teriparatide, or bisphosphonate in patients with postmenopausal osteoporosis: The TERABIT study	14
Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity	14
USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis	14
Damage associated molecular patterns in necrotic femoral head inhibit osteogenesis and promote fibrogenesis of mesenchymal stem cells	14
Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery	14
Bone density and quality in patients treated with direct-acting oral anticoagulants versus warfarin	14
MSTN is a key mediator for low-intensity pulsed ultrasound preventing bone loss in hindlimb-suspended rats	14
Brd4 is required for chondrocyte differentiation and endochondral ossification	13
MicroRNAs and fracture healing: Pre-clinical studies	13
A concise review on the role of selenium for bone cancer applications	13
Nano-hydroxyapatite structures for bone regenerative medicine: Cell-material interaction	13
Whole exome sequencing reveals potentially pathogenic variants in a small subset of premenopausal women with idiopathic osteoporosis	13
Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels	13
PMSA prevents osteoclastogenesis and estrogen-dependent bone loss in mice	13
MI192 induced epigenetic reprogramming enhances the therapeutic efficacy of human bone marrows stromal cells for bone regeneration	13
Sensitive detection of Cre-mediated recombination using droplet digital PCR reveals Tg(BGLAP-Cre) and Tg(DMP1-Cre) are active in multiple non-skeletal tissues	13
Sclerostin antibody improves phosphate metabolism hormones, bone formation rates, and bone mass in adult Hyp mice	13
Verification of efficacy and safety of ibandronate or denosumab for postmenopausal osteoporosis after 12-month treatment with romosozumab as sequential therapy: The prospective VICTOR study	13
High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration	13
CD4+ T-cell activation of bone marrow causes bone fragility and insulin resistance in type 2 diabetes	13
Expression profiling of mitochondria-associated microRNAs during osteogenic differentiation of human MSCs	13
Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineering	13
MicroRNA-26b regulates BMSC osteogenic differentiation of TMJ subchondral bone through β-catenin in osteoarthritis	13
Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging	13
ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress	13
Epidemiology and secular trends of pelvic fractures in Belgium: A retrospective, population-based, nationwide observational study	13
Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs	13
Induction and rescue of skeletal fragility in a high-fat diet mouse model of type 2 diabetes: An in vivo and in vitro approach	13
Bone metabolic marker concentrations across the menstrual cycle and phases of combined oral contraceptive use	13
Osteoclast rich osteopetrosis due to defects in the TCIRG1 gene	13
Pycnodysostosis in children and adults	13
Hypophosphatasia: Vitamin B6 status of affected children and adults	13
Validation of 3D finite element models from simulated DXA images for biofidelic simulations of sideways fall impact to the hip	13
Mechano-structural alteration in proximal femora of individuals with alcoholic liver disease: Implications for increased bone fragility	13