Journal of Applied Physiology

Article	Citations
Impact of COVID-19 on exercise pathophysiology: a combined cardiopulmonary and echocardiographic exercise study	102
Physiological demands of running at 2-hour marathon race pace	87
The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies	78
Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury	64
Muscles from the same muscle group do not necessarily share common drive: evidence from the human triceps surae	64
The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation	62
Evaluating the 35°C wet-bulb temperature adaptability threshold for young, healthy subjects (PSU HEAT Project)	58
Ultrasound imaging to assess skeletal muscle architecture during movements: a systematic review of methods, reliability, and challenges	57
Correction of sensor crosstalk error in Exhalyzer D multiple-breath washout device significantly impacts outcomes in children with cystic fibrosis	54
What makes long-term resistance-trained individuals so strong? A comparison of skeletal muscle morphology, architecture, and joint mechanics	50
The impact of ventilation–perfusion inequality in COVID-19: a computational model	49
Point: Investigators should control for menstrual cycle phase when performing studies of vascular control that include women	49
Counterpoint: Investigators should not control for menstrual cycle phase when performing studies of vascular control that include women	48
Blood flow, capillary transit times, and tissue oxygenation: the centennial of capillary recruitment	47
Let’s talk about sex in the context of COVID-19	45
Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects	44
Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan	44
CORP: The use of deuterated water for the measurement of protein synthesis	42
Exogenous ketosis impacts neither performance nor muscle glycogen breakdown in prolonged endurance exercise	42
Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review	39
Variability in vastus lateralis fiber type distribution, fiber size, and myonuclear content along and between the legs	39
Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications	38
Technological advances in elite marathon performance	37
Physiology and fast marathons	36
High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?	36

Heat therapy: mechanistic underpinnings and applications to cardiovascular health	36
Effects of a concurrent training, respiratory muscle exercise, and self-management recommendations on recovery from post-COVID-19 conditions: the RECOVE trial	36
Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults	35
Arterial structure and function during and after long-duration spaceflight	35
Chronic effects of muscle and nerve-directed stretching on tissue mechanics	34
Blood flow restriction training and the high-performance athlete: science to application	33
Age, sex, and the vascular contributors to cerebral pulsatility and pulsatile damping	33
Neural control of matched motor units during muscle shortening and lengthening at increasing velocities	33
Effect of exercise on myosteatosis in adults: a systematic review and meta-analysis	32
Is the healthy respiratory system built just right, overbuilt, or underbuilt to meet the demands imposed by exercise?	32
High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men	32
Distribution of motor unit properties across human muscles	32
Different antimuscarinics when combined with atomoxetine have differential effects on obstructive sleep apnea severity	31
NIRS-derived skeletal muscle oxidative capacity is correlated with aerobic fitness and independent of sex	30
Comprehensive stereological assessment of the human lung using multiresolution computed tomography	30
Edward F. Adolph Distinguished Lecture. Skeletal muscle atrophy: Multiple pathways leading to a common outcome	28
Making Mice Mighty: recent advances in translational models of load-induced muscle hypertrophy	28
Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies	28
Individual differences in the neural strategies to control the lateral and medial head of the quadriceps during a mechanically constrained task	27
Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism	27
Satellite cell and myonuclear accretion is related to training-induced skeletal muscle fiber hypertrophy in young males and females	26
Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults	26
Human skeletal muscle-specific atrophy with aging: a comprehensive review	26
Surface EMG cross talk quantified at the motor unit population level for muscles of the hand, thigh, and calf	25
From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection	25
Sixteen weeks of testosterone with or without evoked resistance training on protein expression, fiber hypertrophy and mitochondrial health after spinal cord injury	24
Barriers in translating preclinical rodent exercise metabolism findings to human health	24
A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice	24
Skeletal muscle adaptations to heat therapy	24
Inspiratory muscle strength training lowers blood pressure and sympathetic activity in older adults with OSA: a randomized controlled pilot trial	24
Time to reconsider how ventilation is regulated above the respiratory compensation point during incremental exercise	24
Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women	23
Improvements in skeletal muscle fiber size with resistance training are age-dependent in older adults: a systematic review and meta-analysis	23
Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity	23
Pulmonary artery banding is a relevant model to study the right ventricular remodeling and dysfunction that occurs in pulmonary arterial hypertension	23
Differential changes in muscle architecture and neuromuscular fatigability induced by isometric resistance training at short and long muscle-tendon unit lengths	22
Improved agreement between N2 and SF6 multiple-breath washout in healthy infants and toddlers with improved EXHALYZER D sensor performance	22
Mechanical cardiopulmonary interactions during exercise in health and disease	22
The glymphatic system and its role in cerebral homeostasis	22
The influence of longitudinal muscle fascicle growth on mechanical function	21
The validity and reliability of ultra-short-term heart rate variability parameters and the influence of physiological covariates	21
Positive end-expiratory pressure affects geometry and function of the human diaphragm	21
The health benefits of passive heating and aerobic exercise: To what extent do the mechanisms overlap?	21
Early hours in the development of high-altitude pulmonary edema: time course and mechanisms	21
Automated cross-sectional analysis of trained, severely atrophied, and recovering rat skeletal muscles using MyoVision 2.0	21
Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight	21
Selectivity and excitability of upper-limb muscle activation during cervical transcutaneous spinal cord stimulation in humans	21
Altered airway mechanics in the context of obesity and asthma	20
Acute mountain sickness: Do different time courses point to different pathophysiological mechanisms?	20
Universal spectral profile and dynamic evolution of muscle activation: a hallmark of muscle type and physiological state	20

Proprioception: a new look at an old concept	20
Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice	19
Neuromuscular and perceptual mechanisms of fatigue accompanying task failure in response to moderate-, heavy-, severe-, and extreme-intensity cycling	19
LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury	19
Pathophysiology and management of critical illness polyneuropathy and myopathy	19
Sex differences in the physiological responses to exercise-induced dehydration: consequences and mechanisms	19
Factors determining training-induced changes in V̇O2max, critical power, and V̇O2 on-kinetics in skeletal muscle	19
Critical environmental limits for young, healthy adults (PSU HEAT Project)	19
Lower limb massage in humans increases local perfusion and impacts systemic hemodynamics	19
Utilization of the repeated squat-stand model for studying the directional sensitivity of the cerebral pressure-flow relationship	19
Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation in women	19
The balance of muscle oxygen supply and demand reveals critical metabolic rate and predicts time to exhaustion	19
The academic biomedical research laboratory as a “small business”	18
Human skeletal muscle fiber type-specific responses to sprint interval and moderate-intensity continuous exercise: acute and training-induced changes	18
Assessment of macrovascular and microvascular function in aging males	18
One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment	18
Interaction of exercise bioenergetics with pacing behavior predicts track distance running performance	18
Effects of resveratrol or estradiol on postexercise endothelial function in estrogen-deficient postmenopausal women	18
Aging reduces cerebral blood flow regulation following an acute hypertensive stimulus	18
Increased sympathetic responses induced by chronic obstructive sleep apnea are caused by sleep fragmentation	18
Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise	18
Effect of acetazolamide on susceptibility to central sleep apnea in chronic spinal cord injury	18
Slight power output manipulations around the maximal lactate steady state have a similar impact on fatigue in females and males	18
Dynamic not isometric training blunts osteo-renal disease and improves the sclerostin/FGF23/Klotho axis in maintenance hemodialysis patients: a randomized clinical trial	18
Motor unit firing rates during constant isometric contraction: establishing and comparing an age-related pattern among muscles	17
Muscle fiber typology is associated with the incidence of overreaching in response to overload training	17
Six-month longitudinal tracking of arterial stiffness and blood pressure in young adults following SARS-CoV-2 infection	17
Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy	17
Effect of a single bout of exercise on clock gene expression in human leukocyte	17
Neural adaptations to long-term resistance training: evidence for the confounding effect of muscle size on the interpretation of surface electromyography	17
Respiratory and cardiopulmonary limitations to aerobic exercise capacity in adults born preterm	17
Icing after eccentric contraction-induced muscle damage perturbs the disappearance of necrotic muscle fibers and phenotypic dynamics of macrophages in mice	17
β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men	17
Coingestion of protein and carbohydrate in the early recovery phase, compared with carbohydrate only, improves endurance performance despite similar glycogen degradation and AMPK phosphorylation	17
Appendicular lean mass is lower in late compared with early perimenopausal women: potential role of FSH	17
Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women	17
Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults	16
Blood flow restriction exercise stimulates mobilization of hematopoietic stem/progenitor cells and increases the circulating ACE2 levels in healthy adults	16
Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals	16
The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population	16
Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne muscular dystrophy	16
Effects of head-down tilt bed rest plus elevated CO2 on cognitive performance	16
High-intensity exercise impairs extradiaphragmatic respiratory muscle perfusion in patients with COPD	16
Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study	16
Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people	16
Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice	16
Diaphragm neurostimulation during mechanical ventilation reduces atelectasis and transpulmonary plateau pressure, preserving lung homogeneity and PaO2/FiO2	16
Current perspectives on obesity and skeletal muscle contractile function in older adults	16
Dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in middle and posterior cerebral arteries in young endurance-trained women	16
Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction	16
Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking	16
Popliteal flow-mediated dilatory responses to an acute bout of prolonged sitting between earlier and later phases of natural menstrual and oral contraceptive pill cycles	16
High-flow nasal cannula compared with continuous positive airway pressure: a bench and physiological study	16
Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss	16
Countering disuse atrophy in older adults with low-volume leucine supplementation	16
Mechanical countermeasures to headward fluid shifts	15
Resistance exercise training induces subcutaneous and visceral adipose tissue browning in Swiss mice	15
A (Baker’s) dozen tips for enhancing early-stage academic career development in biomedical research	15
Endothelin-1-induced endothelial microvesicles impair endothelial cell function	15
Quantifying upper limb motor impairment in chronic stroke: a physiological profiling approach	15
Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study	15
Repeated eccentric contractions positively regulate muscle oxidative metabolism and protein synthesis during cancer cachexia in mice	15
Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth	15
Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease	15
Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI	15
Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats	15
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans	15
Changes in quadriceps femoris muscle perfusion following different degrees of cold-water immersion	15
Airway luminal area and the resistive work of breathing during exercise in healthy young females and males	15
Effects of 12 weeks of aerobic versus combined aerobic plus resistance exercise training on short-term blood pressure variability in patients with hypertension	15
Greater lactate accumulation following an acute bout of high-intensity exercise in males suppresses acylated ghrelin and appetite postexercise	15
Acute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals	14
Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day head-down tilt bed rest	14
Age has no effect on ankle proprioception when movement history is controlled	14
The invention of hypoxia	14
Effects of high-intensity intermittent exercise on the contractile properties of human type I and type II skeletal muscle fibers	14
Human adaptation to hypoxia in critical illness	14
Polarity-dependent adaptations of motoneuron electrophysiological properties after 5-wk transcutaneous spinal direct current stimulation in rats	14
Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion	14
Maximal strength training in patients with Parkinson’s disease: impact on efferent neural drive, force-generating capacity, and functional performance	14

Effects of elevated positive end-expiratory pressure on diaphragmatic blood flow and vascular resistance during mechanical ventilation	14
Musings on mentoring: teach your “children” well	14
Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes	14
Effects of myocardial function and systemic circulation on regional coronary perfusion	14
Shorter muscle fascicle operating lengths increase the metabolic cost of cyclic force production	14
Lower body negative pressure reduces jugular and portal vein volumes and counteracts the elevation of middle cerebral vein velocity during long-duration spaceflight	14
Human skeletal muscle size with ultrasound imaging: a comprehensive review	14
A time course for markers of protein synthesis and degradation with hindlimb unloading and the accompanying anabolic resistance to refeeding	14
Psychrometric limits and critical evaporative coefficients for exercising older women	14
Ventilation heterogeneity in smokers: role of unequal lung expansion and peripheral lung structure	14
The V̇e/V̇co2 slope: a useful tool to evaluate the physiological status of children with congenital heart disease	14
Effect of neuromuscular electrical stimulation on skeletal muscle size and function in patients with breast cancer receiving chemotherapy	14
Buspirone decreases susceptibility to hypocapnic central sleep apnea in chronic SCI patients	14
The effects of diet composition and chronic obesity on muscle growth and function	14
Influence of joint angle on muscle fascicle dynamics and rate of torque development during isometric explosive contractions	13
The effect of seasonal acclimatization on whole body heat loss response during exercise in a hot humid environment with different air velocity	13
Minimizing airflow turbulence in women lowers the work of breathing to levels similar to men	13
Genetics of pulmonary hypertension and high-altitude pulmonary edema	13
Tenascin-C deficiency impairs alveolarization and microvascular maturation during postnatal lung development	13
Combining cooling or heating applications with exercise training to enhance performance and muscle adaptations	13
Reduced muscle strength in patients with long-COVID-19 syndrome is mediated by limb muscle mass	13
Iron metabolism in high-altitude residents	13
Cerebrovascular response to an acute bout of low-volume high-intensity interval exercise and recovery in young healthy adults	13
Nutritional considerations to counteract gastrointestinal permeability during exertional heat stress	13
Lung and chest wall mechanics in patients with acute respiratory distress syndrome, expiratory flow limitation, and airway closure	13
The supine position improves but does not normalize the blunted pulmonary capillary blood volume response to exercise in mild COPD	13
Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity	13
Rapid changes in vascular compliance contribute to cerebrovascular adjustments during transient reductions in blood pressure in young, healthy adults	13
Reliability of diaphragmatic motor-evoked potentials induced by transcranial magnetic stimulation	13
Distinct contributions of skin and core temperatures to flow-mediated dilation of the brachial artery following passive heating	13
Whole body passive heating versus dynamic lower body exercise: a comparison of peripheral hemodynamic profiles	13
Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels	13
Intermittent short-arm centrifugation is a partially effective countermeasure against upright balance deterioration following 60-day head-down tilt bed rest	13
Skeletal muscle mitochondrial dysfunction and muscle and whole body functional deficits in cancer patients with weight loss	13
Arterial load and right ventricular-vascular coupling in pulmonary hypertension	13
Shearing the brain	13
Enhanced splenic volume and contraction in elite endurance athletes	13
Comparisons between skeletal muscle imaging techniques and histology in tracking midthigh hypertrophic adaptations following 10 wk of resistance training	13
Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days	12
To grant you an edge: Part 2. Tactical tips for addressing specific aspects of biomedical research proposals	12
Do we need to change the guideline values for determining low bone mineral density in athletes?	12
Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction	12
Traube–Hering waves are formed by interaction of respiratory sinus arrhythmia and pulse pressure modulation in healthy men	12
Impact of COVID-19 on ambulatory blood pressure in young adults: a cross-sectional analysis investigating time since diagnosis	12
Biometrics from a wearable device reveal temporary effects of COVID-19 vaccines on cardiovascular, respiratory, and sleep physiology	12
Quantification of mitochondrial membrane potential in the isolated rat lung using rhodamine 6G	12
Aerobic exercise training improves endothelial function and attenuates blood pressure reactivity during maximal exercise in chronic kidney disease	12
Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle	12
Sucking versus swallowing coordination, integration, and performance in preterm and term infants	12
The unfortunately long life of some retracted biomedical research publications	12
Diving deep: understanding the genetic components of hypoxia tolerance in marine mammals	12
To grant you an edge: Part 1. General strategies for writing competitive biomedical research proposals	12
Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation—a patient-level data meta-analysis	12
Tongue muscle contractile, fatigue, and fiber type properties in rats	12
Assessment of cerebrovascular responses to physiological stimuli in identical twins using multimodal imaging and computational fluid dynamics	12
Exercise and physical activity in cirrhosis: opportunities or perils	12
Hypoxic preconditioning attenuates ischemia-reperfusion injury in young healthy adults	12
Mechanisms of neuromuscular fatigue and recovery in unilateral versus bilateral maximal voluntary contractions	12
Validity and reliability of a protocol to establish human critical environmental limits (PSU HEAT Project)	12
Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle	12
Experimental validation of a mean systemic pressure analog against zero-flow measurements in porcine VA-ECMO	12
Elevated exercise blood pressure in middle-aged women is associated with altered left ventricular and vascular stiffness	12
To grant you an edge. Part 3. Considerations for writing competitive research career development proposals in the biomedical sciences	12
Effects of inorganic nitrate supplementation on cardiovascular function and exercise tolerance in heart failure	12
Regional collagen turnover and composition of the human patellar tendon	12
Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction	12
Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons	12
Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice	12
ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training	12
Hemodynamics of postexercise versus post-hot water immersion recovery	12
Interleukin-6 is higher in naturally menstruating women compared with oral contraceptive pill users during the low-hormone phase	11
Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bed rest	11
Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats	11
Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring	11
CORP: quantification of human skeletal muscle carnosine concentration by proton magnetic resonance spectroscopy	11
Relationship between maximal aerobic power with aerobic fitness as a function of signal-to-noise ratio	11
Mapping the relationships between joint stiffness, modeled muscle stiffness, and shear wave velocity	11
The buffer power of blood: a reappraisal of its mathematical expressions with implications on the role of albumin as a buffer	11
Physiological changes and compensatory mechanisms by the action of respiratory muscles in a porcine model of phrenic nerve injury	11
CPAP combined with oral appliance therapy reduces CPAP requirements and pharyngeal pressure swings in obstructive sleep apnea	11
Impact of supine exercise on muscle deoxygenation kinetics heterogeneity: mechanistic insights into slow pulmonary oxygen uptake dynamics	11
Recruitment order of motor neurons promoted by epidural stimulation in individuals with spinal cord injury	11
The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers	11
Improvements in vascular function in response to acute lower limb heating in young healthy males and females	11
Lung ultrasound features and relationships with respiratory mechanics of evolving BPD in preterm rabbits and human neonates	11
Core temperature responses to compensable versus uncompensable heat stress in young adults (PSU HEAT Project)	11
Hot-water immersion does not increase postprandial muscle protein synthesis rates during recovery from resistance-type exercise in healthy, young males	11
Behavior of motor units during submaximal isometric contractions in chronically strength-trained individuals	11
Tidal expiratory flow limitation induces expiratory looping of the alveolar pressure-flow relation in COPD patients	11
Diaphragm neuromuscular transmission failure in a mouse model of an early-onset neuromotor disorder	11
Vaping disrupts ventilation-perfusion matching in asymptomatic users	11
Neuromuscular electrical stimulation resistance training enhances oxygen uptake and ventilatory efficiency independent of mitochondrial complexes after spinal cord injury: a randomized clinical trial	11
Molecular markers of skeletal muscle hypertrophy following 10 wk of resistance training in oral contraceptive users and nonusers	11
Differential activation of the human costal and crural diaphragm during voluntary and involuntary breaths	11
Free Achilles tendon strain during selected rehabilitation, locomotor, jumping, and landing tasks	11