Journal of Applied Physiology

Article	Citations
Fragile bones of elite cyclists: to treat or not to treat?	130
Proximal pulmonary arterial remodeling impairs right ventricular-arterial coupling in postcapillary pulmonary hypertension patients	118
Understanding exercise (in)tolerance in sickle cell disease: impacts of hemolysis and exercise training on skeletal muscle oxygen delivery	91
Hemodynamic modeling of the circle of Willis reveals unanticipated functions during cardiovascular stress	82
Intermittent hypoxia: a call for harmonization in terminology	66
High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?	65
Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women	59
Last Word on Viewpoint: Small airways vs. large airways in asthma: time for a new perspective—Size does not matter: airway interactions determine respiratory dys(function)	58
Diaphragm neurostimulation during mechanical ventilation reduces atelectasis and transpulmonary plateau pressure, preserving lung homogeneity and PaO2/FIO2	58
Further theoretical and practical experimentation required for implementing new approaches in cardiac efficiency estimation	53
Role of hyperpnea in the relaxant effect of inspired CO2on methacholine-induced bronchoconstriction	52
Do we need to change the guideline values for determining low bone mineral density in athletes?	51
Reply to Grassi and Quaresima	48
Parasternal intercostal function during sustained hypoxia	48
Reply to Looney et al.	47
A new look at ocular glymphatic transport in space	45
Reply to Phillips’ response to commentary on USCOM 1A Doppler and Physioflow bioimpedance hemodynamic monitoring in athletes during head-up tilt tests	45
Interdisciplinary collaboration needed to address the heat-health challenge in a warming climate	41
Comparing lung oscillometry with a novel, portable flow interrupter device to measure lung mechanics	41
Reply to Horn et al.	37
Last Word on Viewpoint: Differential impact of shear rate in the cerebral and systemic circulation: implications for endothelial function	36
Athletics should embrace technology, not nostalgia	36
Effects of total knee arthroplasty on skeletal muscle structure and function at the cellular, organellar, and molecular levels	35
Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt	35
Influence of the fitting window on the O2 uptake kinetics at the onset of moderate intensity exercise	34

(Can) what does not kill you make you stronger (?)	34
Underrepresentation of women in exercise science and physiology research is associated with authorship gender	34
Technological advances in elite running sport concerning advanced footwear technology: yes, but individual preconditions must be considered	34
Eight weeks of heavy strength training increases hemoglobin mass and V̇o2peak in well-trained to elite female and male rowers	33
The excessive presence of technology in sports: Are we overvaluing its capabilities?	33
Impact of changes in tissue optical properties on near-infrared diffuse correlation spectroscopy measures of skeletal muscle blood flow	33
The paradox of technology bans in sports: ensuring fairness and performance	33
Reply to Finsterer and Scorza: “Exercise intolerance in post-COVID syndrome cannot only be due to skeletal muscle impairment”	33
A steady interest of analytical approaches to quantify skeletal muscle force control	32
Exploring sex differences in performance: expanding the concept of force unsteadiness	32
Back to the future	31
Combined cardiovascular effects of ovariectomy and high-intensity interval training in female spontaneously hypertensive rats	31
Muscle blood flow and vasodilation are blunted at the onset of exercise following an acute bout of ischemia-reperfusion	29
Work, life, and exercise: the interconnected pathways to health and productivity	28
Persistent physiological benefits from doping? Ethical implications for sports integrity	27
Commentaries on Viewpoint: Using V̇o2max as a marker of training status in athletes – can we do better?	26
Elevations in sweat sodium concentration following ischemia-reperfusion injury during passive heat stress	26
Braving the new world	26
To grant you an edge. Part 3. Considerations for writing competitive research career development proposals in the biomedical sciences	26
Toward a unified understanding of blood buffer power	26
Eccentric muscle contraction potentiates titin stiffness-related contractile properties in rat fast-twitch muscles	26
Enjoying the journey of academia and research	26
The ventilatory response to modified rebreathing is unchanged by hyperoxic severity: implications for the hyperoxic hyperventilation paradox	25
High sodium intake differentially impacts brachial artery dilation when evaluated with reactive versus active hyperemia in salt resistant individuals	25
A small (but interesting) “trans-Atlantic acid-base debate”	25
Dynamics of the cerebral autoregulatory response to paced hyperventilation assessed using subcomponent and time-varying analyses	25
Heart rate variability during exercise can quantify cardiorespiratory deconditioning in 55- to 65-year-old men and women exposed to head-down bed rest	24
Small airways vs large airways in asthma: time for a new perspective	24
To grant you an edge: Part 1. General strategies for writing competitive biomedical research proposals	24
Structure-function in smokers: when a small airways test really reflects the small airways	24
Let’s talk about sex, let’s talk about pulsatility, let’s talk about all the good things and the bad things of MCAv	24
Further characterizing the physiological process of posterior globe flattening in spaceflight associated neuro-ocular syndrome with generative adversarial networks	24
Revisiting the effects of the reciprocal function between alveolar ventilation and CO2 partial pressure (PACO2) on PACO2 homeostasis at rest and in exercise	23
Exercise microdosing for skeletal muscle health applications to spaceflight	23
Arterial stiffness responses to prolonged sitting combined with a high-glycemic-index meal: a double-blind, randomized crossover trial	23
CT-derived measurements of pulmonary blood volume in small vessels and the need for supplemental oxygen in COVID-19 patients	23
Mechanistic insights and clinical applications of age and sex differences in the oxygen cost of breathing	23
Recovery after histamine challenge test: effect of gender and body mass index	22
Optimal hematocrit theory: a review	22
The effect of statins on RyR and RyR-associated disease	22
Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model	22
Arterial blood gas measurements during deep open-water breath-hold dives	22
The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia	21
Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk	21
Reply to Lemaître and Costalat	21
Extracorporeal circulation impairs microcirculation perfusion and organ function	20
An acute bout of prolonged sitting blunts popliteal endothelium-independent dilation in young, healthy adults	20
Case Studies in Physiology: Cardiopulmonary exercise testing and inspiratory muscle training in a 59-year-old, 4 years after an extrapleural pneumonectomy	20
Pathogenesis of obstructive sleep apnea in people living with HIV	20
Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex	19

Acute exercise rapidly activates hepatic mitophagic flux	19
Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients	19
Task-dependent neural control of regions within human genioglossus	19
Insulin blood-brain barrier transport and interactions are greater following exercise in mice	19
Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle	19
Exercise effects on γ3-AMPK activity, Akt substrate of 160 kDa phosphorylation, and glucose uptake in muscle of normal and insulin-resistant female rats	19
Nitrogen-based lung clearance index: a valid physiological biomarker for the clinic	19
The influence of sex and maturation on carotid and vertebral artery hemodynamics and associations with free-living (in)activity in 6–17-year-olds	19
Testosterone undecanoate administration prevents declines in fat-free mass but not physical performance during simulated multi-stressor military operations	18
Extracellular matrix content and remodeling markers do not differ in college-aged men classified as higher and lower responders to resistance training	18
CORP: Gene delivery into murine skeletal muscle using in vivo electroporation	18
Lung mechanical constraints: the Achilles’ heel of excess exertional ventilation for prognosis assessment?	18
Peripheral hypercapnic chemosensitivity in trained and untrained females and males during exercise	18
Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury	18
A leak-free head-out plethysmography system to accurately assess lung function in mice	18
Decrease in work rate in order to keep a constant heart rate: biomarker of exercise intolerance following a 10-day bed rest	18
Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice	18
Circulating long-chain acylcarnitine concentrations are not affected by exercise training in pregnant women with obesity	18
Premature birth: a neglected consideration for altitude adaptation	18
Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone	17
Common synaptic input between motor units from the lateral and medial posterior soleus compartments does not differ from that within each compartment	17
Evidence for a sigmoidal flow-to-valve opening relation in low-flow low-gradient aortic stenosis	17
Two weeks of high-intensity interval training increases skeletal muscle mitochondrial respiration via complex-specific remodeling in sedentary humans	17
The effect of single bout and prolonged aerobic exercise on tumor hypoxia in mice	17
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration	17
Pressing physiology to move our understanding of cytosolic calcium dynamics	17
Modifying the ICP pulse wave: effects on parenchymal blood flow pulsatility	17
The effect of exercise hyperpnea on gross efficiency and anaerobic capacity estimates during a 3-min cycle time trial	17
Renal vascular conductance is unrelated to leg vascular conductance or muscle sympathetic nerve activity at rest and during stress in humans	16
Negative-pressure-assisted ventilation lowers driving pressure and mechanical power in an ARDS model	16
Heating-induced peripheral limb microvascular vasodilation reduces arterial wave reflection	16
Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex	16
Relationship between muscle venous blood oxygenation and near-infrared spectroscopy: quantitative analysis of the Hb and Mb contributions	16
Inspiratory and leg muscle blood flows during inspiratory muscle metaboreflex activation in heart failure with preserved ejection fraction	16
Case Studies in Physiology: Is blackout in breath-hold diving related to cardiac arrhythmias?	16
Core body temperature changes before sleep are associated with nocturnal heart rate variability	16
Greater aortic perivascular adipose tissue density is associated with aging, aortic stiffness, and central blood pressure in humans	16
Multiomics profiling of the impact of an angiotensin (1–7)-expressing probiotic combined with exercise training in aged male rats	16
Ulk1 phosphorylation at S555 is not required for endurance training-induced improvements in exercise and metabolic capacity in mice	15
Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats	15
Fingolimod, a sphingosine-1-phosphate receptor modulator, prevents neonatal bronchopulmonary dysplasia and subsequent airway remodeling in a murine model	15
Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial	15
Airway tree caliber heterogeneity and airflow obstruction among older adults	15
Cocoa flavanols protect cognitive function, cerebral oxygenation, and mental fatigue during severe hypoxia	15
Does one biopsy cut it? Revisiting human muscle fiber type composition variability using repeated biopsies in the vastus lateralis and gastrocnemius medialis	15
The effect of increasing work rate amplitudes from a common metabolic baseline on the kinetic response of V̇o2p, blood flow, and muscle deoxygenation	15
Supporting evidence for an “arterial pump” venous return mechanism in humans	15
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study	15
Enhancing flow-mediated dilation analysis by optimizing an open-source software with automated edge detection	15
Habitually wearing high heels may improve user walking economy in any footwear	14
Fatty acids and albumin bond to control metabolic function	14
Cardioautonomic control in healthy singleton and twin pregnancies	14
Comparison of analysis strategies to assess sex differences in microvascular reperfusion using near-infrared spectroscopy	14
Respiratory and chest wall mechanics in very preterm infants	14
High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans	14
Lower maximal skin wettedness in both warm-humid and hot-dry environments with advanced age (PSU HEAT project)	14
The effect of trunk position and pain location on lumbar extensor muscle recruitment strategies	14
Effect of glycocalyx-targeted therapy on vascular function in older adults: a randomized controlled trial	14
Effects of variation in exercise training load on cognitive performances and neurotrophic biomarkers in patients with coronary artery disease	14
Comorbidity of cardiorespiratory and locomotor dysfunction following cervical spinal cord injury in the rat	14
Exercise-induced changes to the fiber type-specific redox state in human skeletal muscle are associated with aerobic capacity	14
Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared with men	14
Biological sex does not independently influence core temperature change and sweating of children exercising in uncompensable heat stress	14
Effects of single- and bilateral limb immersion on systemic and cerebral hemodynamic responses to the cold pressor test	14
Reduced Achilles tendon stiffness in aging associates with higher metabolic cost of walking	14
Effect of acute heat exposure on the pressor response to a voluntary hypoxic apnea	14
ATP and acetylcholine interact to modulate vascular tone and α1-adrenergic vasoconstriction in humans	13
Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss	13
The effect of seasonal acclimatization on whole body heat loss response during exercise in a hot humid environment with different air velocity	13
Carotid sinus nerve transection abolishes the facilitation of breathing that occurs upon cessation of a hypercapnic gas challenge in male mice	13
Exogenous ketone salts inhibit superoxide production in the rat caudal solitary complex during exposure to normobaric and hyperbaric hyperoxia	13
Icing after eccentric contraction-induced muscle damage perturbs the disappearance of necrotic muscle fibers and phenotypic dynamics of macrophages in mice	13
Partitioning the work of breathing during running and cycling using optoelectronic plethysmography	13
GABAA receptor activation modulates the muscle sympathetic nerve activity responses at the onset of static exercise in humans	13
Induced blood flow oscillations at 0.1 Hz protects oxygenation of severely ischemic tissue in humans	13
A homological approach to a mathematical definition of pulmonary fibrosis and emphysema on computed tomography	13
Depolarized mitochondrial membrane potential and protection with duroquinone in isolated perfused lungs from rats exposed to hyperoxia	13
Diaphragm muscle function in a mouse model of early-onset spasticity	13
A novel murine muscle loading model to investigate Achilles musculotendinous adaptation	13
Microvascular fluid flow in ex vivo and engineered lungs	13

Skeletal muscle phenotype signaling with ex vivo endurance-type dynamic contractions in rat muscle	13
Six-year follow-up of a world record-breaking master marathon runner	13
Intravital assessment of precapillary pulmonary arterioles of type 1 diabetic mice shows oxidative damage and increased tone in response to NOS inhibition	13
In vivo assessment of changes to canine airway smooth muscle following bronchial thermoplasty with OR-OCT	13
Skeletal muscle mitochondrial dysfunction and muscle and whole body functional deficits in cancer patients with weight loss	13
A dynamic model of the body gas stores for carbon dioxide, oxygen, and inert gases that incorporates circulatory transport delays to and from the lung	13
Human adipose and skeletal muscle tissue DNA, RNA, and protein content	12
The duration of glucocorticoid treatment alters the anabolic response to high-force muscle contractions	12
Influence of habitual aerobic and resistance exercise on cerebrovascular reactivity in healthy young adults	12
Tramadol is a performance-enhancing drug in highly trained cyclists: a randomized controlled trial	12
Sex differences in human running performance: smaller gaps at shorter distances?	12
Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex	12
Sex-specific maturation of muscle metabolites carnosine, creatine, and carnitine over puberty: a longitudinal follow-up study	12
Multitissue responses to exercise: a MoTrPAC feasibility study	12
Cerebral endothelium-dependent function and reactivity to hypercapnia: the role of α1-adrenoreceptors	12
Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity	12
Physiological impacts of computed tomography airway dysanapsis, fractal dimension, and branch count in asymptomatic never smokers	12
Motor cortex plasticity is greater in endurance-trained cyclists following acute exercise	12
A novel method for determining ventilatory and gas exchange dynamics during exercise: the “chirp” waveform	12
Influences on glycocalyx shedding during the Yukon Arctic Ultra: the longest and the coldest ultramarathon	12
Endothelial-derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function	12
Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes	12
Inspiratory muscle responses to sudden airway occlusion in chronic obstructive pulmonary disease	12
Timing of resistance exercise and cardiometabolic outcomes in adults with prediabetes: a secondary analysis	11
Comparison of mild physiological effects of surgical masks and N95 respirators over 60 min at rest	11
Corrigendum for Eskelinen et al., volume 118, 2015, p. 1172–1180	11
Commentaries on Viewpoint: A (Baker’s) dozen tips for enhancing early-stage academic career development in biomedical research	11
Reply to Henry and Tsuda	11
Power attenuation from restricting range of motion is minimized in subjects with fast RTD and following isometric training	11
Corrigendum for Rosenberg et al., volume 130, 2021, p. 1786–1797	11
The effect of minimal differences in the skin-to-air vapor pressure gradient at various dry-bulb temperatures on self-paced exercise performance	11
Respiratory muscle strength pre- and post-maximal apneas in a world champion breath-hold diver	11
New evidence for baroreflex and respiratory chemoreflex-mediated cerebral sympathetic activation in humans	11
Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension	11
Remote ischemic preconditioning attenuates ischemia-reperfusion injury-induced reductions in vascular function through release of endogenous opioids	11
Peripheral hypercapnic chemosensitivity at rest and progressive exercise intensities in males and females	11
Imaging-based assessment of lung function in a population cooking indoors with biomass fuel: a pilot study	11
Protective ventilation in a pig model of acute lung injury: timing is as important as pressure	11
Muscle stretching induces the mechanoreflex response in human arterial blood pressure	11
Social jet lag impairs exercise volume and attenuates physiological and metabolic adaptations to voluntary exercise training	11
Unacylated ghrelin, leptin, and appetite display diurnal rhythmicity in lean adults	11
The extraction of neural strategies from the surface EMG: 2004–2024	11
Short bouts of hypoxia improve insulin sensitivity in adults with type 2 diabetes	11
Recruitment order of motor neurons promoted by epidural stimulation in individuals with spinal cord injury	11
Estimation of maximal muscle electromyographic activity from the relationship between muscle activity and voluntary activation	11
Corrigendum for Sutehall S et al., volume 130, 2021, p. 1421–1426	11
Brief exposure to intermittent hypoxia increases erythropoietin levels in older adults	11
Acute cardiovascular effects of 4th generation electronic cigarettes and combusted cigarettes: implications for harm reduction	11
The validity and reliability of a novel isotope ratio infrared spectrometer to quantify 13C enrichment of expired breath samples in exercise	11
The influence of sex, hemoglobin mass, and skeletal muscle characteristics on cycling critical power	11
Observing changes in motoneuron characteristics following distorted sensorimotor input via blood flow restriction	11
Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in patients with advanced cancer	10
Contact-free assessments of respiratory rate and volume with load cells under the bed legs in ventilated patients: a prospective exploratory observational study	10
Structural and functional impairments of skeletal muscle in patients with postacute sequelae of SARS-CoV-2 infection	10
Critical environmental limits for young, healthy adults (PSU HEAT Project)	10
Cognitive performance is lower among individuals with overlap syndrome than in individuals with COPD or obstructive sleep apnea alone: association with carotid artery stiffness	10
Investigating the roles of exercise intensity and biological sex on postexercise alterations in cardiac function	10
Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne muscular dystrophy	10
Ultra-Endurance triathlon competition shifts fecal metabolome independent of changes to microbiome composition	10
Sex differences in human running performance: what about mountain ultramarathon?	10
Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition	10
Effects of aging on conditional visuomotor learning for grasping and lifting eccentrically weighted objects	10
Regional lung volume changes with noninvasive positive pressure ventilation in healthy adults	10
Leg stiffness adjustment during hopping by dynamic interaction between the muscle and tendon of the medial gastrocnemius	10
Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men	10
The balance of muscle oxygen supply and demand reveals critical metabolic rate and predicts time to exhaustion	10
Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women	10
Blood pressure in human large cerebral arteries: a feasibility study	10
COVID-19 controls causing a kerfuffle	10
Motor-evoked potentials in the human upper and lower limb do not increase after single 30-min sessions of acute intermittent hypoxia	10
Differences in substrate metabolism between African American and Caucasian infants: evidence from mesenchymal stem cells	10
Firing rate trajectories of human motor units during activity-dependent muscle potentiation	10
High-intensity exercise and passive hot water immersion cause similar postintervention changes in peripheral and cerebral shear	10
Redefining muscular action: Human “adductor” magnus is designed to act primarily for hip “extension” rather than adduction in living young individuals	10
Sex differences in energy balance, body composition, and metabolic and endocrine markers during prolonged arduous military training	10
Intralaryngeal application of ATP evokes apneic response mainly via acting on P2X3 (P2X2/3) receptors of the superior laryngeal nerve in postnatal rats	10
Muscle-derived microRNAs correlated with thigh lean mass gains during progressive resistance training in older adults	10
A novel method for tracking nitrogen kinetics in vivo under hyperbaric conditions using radioactive nitrogen-13 gas and positron emission tomography	10
Comment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”	9
Running for two (or three!): the journey of an ultramarathoner across two pregnancies	9
Flaws in the Van Slyke buffer algorithm?	9
Differential impact of shear rate in the cerebral and systemic circulation: implications for endothelial function	9
Last Word on Viewpoint: COVID controls causing a kerfuffle	9
Predicting mortality for patients with heart failure beyond oxygen consumption: a prognostic risk score	9
Ventilation-perfusion inequality in COVID-19 pneumonia	9
Potentiation of active force by cyclic strain in sheep carotid arterial smooth muscle	9
Last Word on Viewpoint: Using V̇o2max as a marker of training status in athletes–can we do better?	9
Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males	9
ELEVATED CIRCULATING ENDOTHELIAL CELL-DERIVED MICROVESICLES: A BIOMARKER OF ENDOTHELIAL VASOMOTOR DYSFUNCTION IN ADULTS WITH OBESITY	9
Much ado about albumin: solving the controversy around its buffering properties	9
Addressing structural racism within institutional bodies regulating research	9
Macrophage immunomodulation accelerates skeletal muscle functional recovery in aged mice following disuse atrophy	9
Efficacy of perinatal pharmacotherapeutic actions for survival of very preterm newborn rabbits at 26-day gestation	9
Immersion-related atelectasis: a possible role in the elusive complications of deep breath-hold diving	9
The albumin, the hydrogen, the carbon dioxide, and the bicarbonate: four substances and a conflict	9