Journal of Applied Physiology

Article	Citations
Impact of COVID-19 on exercise pathophysiology: a combined cardiopulmonary and echocardiographic exercise study	119
Physiological demands of running at 2-hour marathon race pace	99
Evaluating the 35°C wet-bulb temperature adaptability threshold for young, healthy subjects (PSU HEAT Project)	86
Muscles from the same muscle group do not necessarily share common drive: evidence from the human triceps surae	77
Effects of a concurrent training, respiratory muscle exercise, and self-management recommendations on recovery from post-COVID-19 conditions: the RECOVE trial	62
Correction of sensor crosstalk error in Exhalyzer D multiple-breath washout device significantly impacts outcomes in children with cystic fibrosis	60
Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review	58
Counterpoint: Investigators should not control for menstrual cycle phase when performing studies of vascular control that include women	56
Point: Investigators should control for menstrual cycle phase when performing studies of vascular control that include women	55
Blood flow, capillary transit times, and tissue oxygenation: the centennial of capillary recruitment	54
The impact of ventilation–perfusion inequality in COVID-19: a computational model	49
Technological advances in elite marathon performance	49
Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan	47
High-altitude cerebral edema: its own entity or end-stage acute mountain sickness?	46
Variability in vastus lateralis fiber type distribution, fiber size, and myonuclear content along and between the legs	45
Neural control of matched motor units during muscle shortening and lengthening at increasing velocities	45
Human skeletal muscle-specific atrophy with aging: a comprehensive review	44
Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications	42
Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism	42
Age, sex, and the vascular contributors to cerebral pulsatility and pulsatile damping	42
Heat therapy: mechanistic underpinnings and applications to cardiovascular health	39
Blood flow restriction training and the high-performance athlete: science to application	39
Is the healthy respiratory system built just right, overbuilt, or underbuilt to meet the demands imposed by exercise?	39
Chronic effects of muscle and nerve-directed stretching on tissue mechanics	37
Distribution of motor unit properties across human muscles	37

Effect of exercise on myosteatosis in adults: a systematic review and meta-analysis	36
Surface EMG cross talk quantified at the motor unit population level for muscles of the hand, thigh, and calf	35
Anatomical variability in the upper tracheobronchial tree: sex-based differences and implications for personalized inhalation therapies	34
Different antimuscarinics when combined with atomoxetine have differential effects on obstructive sleep apnea severity	32
Reduced muscle strength in patients with long-COVID-19 syndrome is mediated by limb muscle mass	32
The validity and reliability of ultra-short-term heart rate variability parameters and the influence of physiological covariates	30
Selectivity and excitability of upper-limb muscle activation during cervical transcutaneous spinal cord stimulation in humans	29
Satellite cell and myonuclear accretion is related to training-induced skeletal muscle fiber hypertrophy in young males and females	29
Individual differences in the neural strategies to control the lateral and medial head of the quadriceps during a mechanically constrained task	28
Neuromuscular and perceptual mechanisms of fatigue accompanying task failure in response to moderate-, heavy-, severe-, and extreme-intensity cycling	28
Pathophysiology and management of critical illness polyneuropathy and myopathy	27
Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight	27
The influence of longitudinal muscle fascicle growth on mechanical function	27
From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection	27
Automated cross-sectional analysis of trained, severely atrophied, and recovering rat skeletal muscles using MyoVision 2.0	27
Proprioception: a new look at an old concept	27
Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity	26
Barriers in translating preclinical rodent exercise metabolism findings to human health	26
The balance of muscle oxygen supply and demand reveals critical metabolic rate and predicts time to exhaustion	26
Dynamic not isometric training blunts osteo-renal disease and improves the sclerostin/FGF23/Klotho axis in maintenance hemodialysis patients: a randomized clinical trial	25
Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation in women	25
Positive end-expiratory pressure affects geometry and function of the human diaphragm	25
Critical environmental limits for young, healthy adults (PSU HEAT Project)	25
The glymphatic system and its role in cerebral homeostasis	24
The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population	24
Improved agreement between N2 and SF6 multiple-breath washout in healthy infants and toddlers with improved EXHALYZER D sensor performance	23
Altered airway mechanics in the context of obesity and asthma	23
Human skeletal muscle fiber type-specific responses to sprint interval and moderate-intensity continuous exercise: acute and training-induced changes	23
Sex differences in the physiological responses to exercise-induced dehydration: consequences and mechanisms	23
Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne muscular dystrophy	23
Utilization of the repeated squat-stand model for studying the directional sensitivity of the cerebral pressure-flow relationship	22
High-flow nasal cannula compared with continuous positive airway pressure: a bench and physiological study	22
The health benefits of passive heating and aerobic exercise: To what extent do the mechanisms overlap?	22
Six-month longitudinal tracking of arterial stiffness and blood pressure in young adults following SARS-CoV-2 infection	22
LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury	22
Shorter muscle fascicle operating lengths increase the metabolic cost of cyclic force production	22
Acute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals	22
Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss	22
Slight power output manipulations around the maximal lactate steady state have a similar impact on fatigue in females and males	21
Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy	21
Interaction of exercise bioenergetics with pacing behavior predicts track distance running performance	21
Technological advances in elite sport: Where does one draw the line?	21
Factors determining training-induced changes in V̇O2max, critical power, and V̇O2 on-kinetics in skeletal muscle	21
One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment	20
Assessment of macrovascular and microvascular function in aging males	20
Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction	20
Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women	20
Mechanical countermeasures to headward fluid shifts	20
Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology	20
Lower body negative pressure reduces jugular and portal vein volumes and counteracts the elevation of middle cerebral vein velocity during long-duration spaceflight	19

Quantifying upper limb motor impairment in chronic stroke: a physiological profiling approach	19
Motor unit firing rates during constant isometric contraction: establishing and comparing an age-related pattern among muscles	19
Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals	19
Structural and functional impairments of skeletal muscle in patients with postacute sequelae of SARS-CoV-2 infection	19
The academic biomedical research laboratory as a “small business”	19
Comparisons between skeletal muscle imaging techniques and histology in tracking midthigh hypertrophic adaptations following 10 wk of resistance training	19
Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease	18
Icing after eccentric contraction-induced muscle damage perturbs the disappearance of necrotic muscle fibers and phenotypic dynamics of macrophages in mice	18
β2-Adrenergic agonist salbutamol augments hypertrophy in MHCIIa fibers and sprint mean power output but not muscle force during 11 weeks of resistance training in young men	18
Effects of 12 weeks of aerobic versus combined aerobic plus resistance exercise training on short-term blood pressure variability in patients with hypertension	18
Diaphragm neurostimulation during mechanical ventilation reduces atelectasis and transpulmonary plateau pressure, preserving lung homogeneity and PaO2/FiO2	18
Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults	18
Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice	18
Current perspectives on obesity and skeletal muscle contractile function in older adults	18
Effects of head-down tilt bed rest plus elevated CO2 on cognitive performance	18
Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study	18
Neural adaptations to long-term resistance training: evidence for the confounding effect of muscle size on the interpretation of surface electromyography	18
Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans	17
High-intensity exercise impairs extradiaphragmatic respiratory muscle perfusion in patients with COPD	17
Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle	17
Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels	17
Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study	17
Arterial load and right ventricular-vascular coupling in pulmonary hypertension	17
Human skeletal muscle size with ultrasound imaging: a comprehensive review	17
Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity	17
Dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in middle and posterior cerebral arteries in young endurance-trained women	17
Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth	17
Core temperature responses to compensable versus uncompensable heat stress in young adults (PSU HEAT Project)	17
Effect of respiratory rate and size of cannula on pressure and dead-space clearance during nasal high flow in patients with COPD and acute respiratory failure	16
The effects of diet composition and chronic obesity on muscle growth and function	16
Recent COVID-19 vaccination has minimal effects on the physiological responses to graded exercise in physically active healthy people	16
The effect of seasonal acclimatization on whole body heat loss response during exercise in a hot humid environment with different air velocity	16
A (Baker’s) dozen tips for enhancing early-stage academic career development in biomedical research	16
Enhanced splenic volume and contraction in elite endurance athletes	16
Exercise tolerance, fatigue, mental health, and employment status at 5 and 12 months following COVID-19 illness in a physically trained population	16
Do we need to change the guideline values for determining low bone mineral density in athletes?	16
Aerobic exercise training improves endothelial function and attenuates blood pressure reactivity during maximal exercise in chronic kidney disease	16
Age alters the thermoregulatory responses to extreme heat exposure with accompanying activities of daily living	16
Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes	16
Nutritional considerations to counteract gastrointestinal permeability during exertional heat stress	15
Modeling intra-abdominal volume and respiratory driving pressure during pneumoperitoneum insufflation—a patient-level data meta-analysis	15
Lung ultrasound features and relationships with respiratory mechanics of evolving BPD in preterm rabbits and human neonates	15
Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day head-down tilt bed rest	15
Musings on mentoring: teach your “children” well	15
Traube–Hering waves are formed by interaction of respiratory sinus arrhythmia and pulse pressure modulation in healthy men	15
The V̇e/V̇co2 slope: a useful tool to evaluate the physiological status of children with congenital heart disease	15
Free Achilles tendon strain during selected rehabilitation, locomotor, jumping, and landing tasks	15
Airway luminal area and the resistive work of breathing during exercise in healthy young females and males	15
The invention of hypoxia	15
The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers	15
Tongue muscle contractile, fatigue, and fiber type properties in rats	15
Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer’s disease of 3×Tg mice	15
Hemodynamics of postexercise versus post-hot water immersion recovery	15
How velocity impacts eccentric force generation of fully activated skinned skeletal muscle fibers in long stretches	15
Physiological impacts of computed tomography airway dysanapsis, fractal dimension, and branch count in asymptomatic never smokers	15
Reliability of diaphragmatic motor-evoked potentials induced by transcranial magnetic stimulation	14
Daily generation of a footward fluid shift attenuates ocular changes associated with head-down tilt bed rest	14
Impact of COVID-19 on ambulatory blood pressure in young adults: a cross-sectional analysis investigating time since diagnosis	14
Hypoxic preconditioning attenuates ischemia-reperfusion injury in young healthy adults	14
Distinct contributions of skin and core temperatures to flow-mediated dilation of the brachial artery following passive heating	14
To grant you an edge: Part 1. General strategies for writing competitive biomedical research proposals	14
Critical power and work-prime account for variability in endurance training adaptations not captured by V̇o2max	14
Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons	14
Cerebrovascular response to an acute bout of low-volume high-intensity interval exercise and recovery in young healthy adults	14
Physiological responses to 9 hours of heat exposure in young and older adults. Part I: Body temperature and hemodynamic regulation	14
Improvements in vascular function in response to acute lower limb heating in young healthy males and females	13
Interrupting prolonged sitting with repeated chair stands or short walks reduces postprandial insulinemia in healthy adults	13
5-Fluorouracil disrupts skeletal muscle immune cells and impairs skeletal muscle repair and remodeling	13
Validity and reliability of a protocol to establish human critical environmental limits (PSU HEAT Project)	13
Experimental validation of a mean systemic pressure analog against zero-flow measurements in porcine VA-ECMO	13
Skeletal muscle mitochondrial dysfunction and muscle and whole body functional deficits in cancer patients with weight loss	13
Molecular markers of skeletal muscle hypertrophy following 10 wk of resistance training in oral contraceptive users and nonusers	13
Aligning thermal physiology and biometeorological research for heat adaptation and resilience in a changing climate	13
Plasma gelsolin modulates the production and fate of IL-1β-containing microparticles following high-pressure exposure and decompression	13
Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle	13
To grant you an edge: Part 2. Tactical tips for addressing specific aspects of biomedical research proposals	13
Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction	13
Whole body passive heating versus dynamic lower body exercise: a comparison of peripheral hemodynamic profiles	13
Intermittent short-arm centrifugation is a partially effective countermeasure against upright balance deterioration following 60-day head-down tilt bed rest	13
Assessment of cerebrovascular responses to physiological stimuli in identical twins using multimodal imaging and computational fluid dynamics	13

Sucking versus swallowing coordination, integration, and performance in preterm and term infants	13
Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days	13
To grant you an edge. Part 3. Considerations for writing competitive research career development proposals in the biomedical sciences	13
Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring	13
Effects of inorganic nitrate supplementation on cardiovascular function and exercise tolerance in heart failure	12
Interleukin-6 is higher in naturally menstruating women compared with oral contraceptive pill users during the low-hormone phase	12
REDD1 deletion attenuates cancer cachexia in mice	12
Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats	12
Pain-induced changes in motor unit discharge depend on recruitment threshold and contraction speed	12
Physiological dead space during exercise in patients with heart failure with preserved ejection fraction	12
Thiamine treatment preserves cardiac function against ischemia injury via maintaining mitochondrial size and ATP levels	12
The buffer power of blood: a reappraisal of its mathematical expressions with implications on the role of albumin as a buffer	12
Physiological changes and compensatory mechanisms by the action of respiratory muscles in a porcine model of phrenic nerve injury	12
Behavior of motor units during submaximal isometric contractions in chronically strength-trained individuals	12
Recruitment order of motor neurons promoted by epidural stimulation in individuals with spinal cord injury	12
Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis	12
Evidence of reduced peripheral microvascular function in young Black women across the menstrual cycle	12
Technological advances in elite sport: Should a line be drawn?	12
Kidney injury risk during prolonged exposure to current and projected wet bulb temperatures occurring during extreme heat events in healthy young men	12
Increased end-expiratory pressures improve lung function in near-term newborn rabbits with elevated airway liquid volume at birth	12
Diaphragm neuromuscular transmission failure in a mouse model of an early-onset neuromotor disorder	12
Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans	12
A HIF-1 signature dominates the attenuation in the human skeletal muscle transcriptional response to high-intensity interval training	12
Biometrics from a wearable device reveal temporary effects of COVID-19 vaccines on cardiovascular, respiratory, and sleep physiology	12
No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent	11
Neuromuscular electrical stimulation resistance training enhances oxygen uptake and ventilatory efficiency independent of mitochondrial complexes after spinal cord injury: a randomized clinical trial	11
The impact of acute central hypovolemia on cerebral hemodynamics: does sex matter?	11
Impact of inspiratory threshold loading on brain activity and cognitive performances in healthy humans	11
How to incorporate tricuspid regurgitation in right ventricular-pulmonary arterial coupling	11
The impact of obesity on the regulation of muscle blood flow during exercise in patients with heart failure with a preserved ejection fraction	11
CPAP combined with oral appliance therapy reduces CPAP requirements and pharyngeal pressure swings in obstructive sleep apnea	11
Exercise and health: historical perspectives and new insights	11
Reducing intracranial pressure by reducing central venous pressure: assessment of potential countermeasures to spaceflight-associated neuro-ocular syndrome	11
Brain insulin resistance and cognitive function: influence of exercise	11
The exercise power-duration relationship is equally reproducible in eumenorrheic female and male humans	11
Perioperative assessment of muscle inflammation susceptibility in patients with end-stage osteoarthritis	11
Heat therapy: possible benefits for cognitive function and the aging brain	11
Physicochemical properties of abnormal blood acid-base buffering	11
Kinetic differences between macro- and microvascular measures of reactive hyperemia	11
Arterial stiffness responses to prolonged sitting combined with a high-glycemic-index meal: a double-blind, randomized crossover trial	11
CORP: quantification of human skeletal muscle carnosine concentration by proton magnetic resonance spectroscopy	11
Vaping disrupts ventilation-perfusion matching in asymptomatic users	11
A comparison of protocols for simulating hemorrhage in humans: step versus ramp lower body negative pressure	11
Faster triceps surae muscle cyclic contractions alter muscle activity and whole body metabolic rate	11
Lack of increased rate of force development after strength training is explained by specific neural, not muscular, motor unit adaptations	11
Effect of muscle stimulation intensity on the heterogeneous function of regions within an architecturally complex muscle	11
Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults	11
Human adipose and skeletal muscle tissue DNA, RNA, and protein content	11
Small airways vs large airways in asthma: time for a new perspective	10
Arterial blood gas measurements during deep open-water breath-hold dives	10
Effects of fentanyl overdose-induced muscle rigidity and dexmedetomidine on respiratory mechanics and pulmonary gas exchange in sedated rats	10
Cardiovasomobility: an integrative understanding of how disuse impacts cardiovascular and skeletal muscle health	10
Impact of exercise duration on gastrointestinal function and symptoms	10
Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia	10
Preclinical rodent models of physical inactivity-induced muscle insulin resistance: challenges and solutions	10
Using V̇o2max as a marker of training status in athletes—can we do better?	10
Effects of menstrual cycle on appetite-regulating hormones and energy intake in response to cycling exercise in physically active women	10
A comparison of methods used to quantify the work of breathing during exercise	10
Extracellular matrix content and remodeling markers do not differ in college-aged men classified as higher and lower responders to resistance training	10
The effect of minimal differences in the skin-to-air vapor pressure gradient at various dry-bulb temperatures on self-paced exercise performance	10
Exercise training modifies the whole blood DNA methylation profile in middle-aged and older women	10
Small airways dysfunction is associated with increased exacerbations in patients with asthma	10
Physiological responses and perceived comfort to high-flow nasal cannula therapy in awake adults: effects of flow magnitude and temperature	10
Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults	10
Six weeks of static apnea training does not affect Hbmass and exercise performance	10
Short-term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes	10
Influence of prostaglandins and endothelial-derived hyperpolarizing factors on brachial and popliteal endothelial-dependent function in young adults	10
On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise	10
The superior cervical ganglia modulate ventilatory responses to hypoxia independently of preganglionic drive from the cervical sympathetic chain	10
Cognitive performance is lower among individuals with overlap syndrome than in individuals with COPD or obstructive sleep apnea alone: association with carotid artery stiffness	10
Gravitational effects on carotid and jugular characteristics in graded head-up and head-down tilt	10
Midlife aerobic exercise and dynamic cerebral autoregulation: associations with baroreflex sensitivity and central arterial stiffness	10
Mitoquinone mesylate (MitoQ) prevents sepsis-induced diaphragm dysfunction	10
Going against the flow: are venous thromboembolism and impaired cerebral drainage critical risks for spaceflight?	10
Sex differences in NIRS-derived values of reactive hyperemia persist after experimentally controlling for the ischemic vasodilatory stimulus	10
Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics	10
Effect sizes for symptomatic and cognitive improvements in traumatic brain injury following hyperbaric oxygen therapy	10
Severity of central sleep apnea does not affect sleeping oxygen saturation during ascent to high altitude	10
Gravitational effects on intraocular pressure and ocular perfusion pressure	10
The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia	9
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration	9
Sex differences in human running performance: smaller gaps at shorter distances?	9
Inhalational delivery of induced pluripotent stem cell secretome improves postpneumonectomy lung structure and function	9
Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats	9
Extracorporeal circulation impairs microcirculation perfusion and organ function	9
Acute exercise rapidly activates hepatic mitophagic flux	9
Firing rate trajectories of human motor units during activity-dependent muscle potentiation	9
Influence of wide-pulse neuromuscular electrical stimulation frequency and superimposed tendon vibration on occurrence and magnitude of extra torque	9
Effects of −10° and −30° head-down tilt on cerebral blood velocity, dynamic cerebral autoregulation, and noninvasively estimated intracranial pressure	9
Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice	9
CT-derived measurements of pulmonary blood volume in small vessels and the need for supplemental oxygen in COVID-19 patients	9
Upper and lower motor neuron lesions in tetraplegia: implications for surgical nerve transfer to restore hand function	9
Ansa cervicalis stimulation increases pharyngeal patency in patients with obstructive sleep apnea	9
What are the effects of acute exercise and exercise training on cerebrovascular hemodynamics following stroke? A systematic review and meta-analysis	9
Airway closure is the predominant physiological mechanism of low ventilation seen on hyperpolarized helium-3 MRI lung scans	9