RSC Medicinal Chemistry

Article	Citations
Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential antitubercular agents	112
Back cover	109
Back cover	105
Inside front cover	99
Exploration of hydrazine-based small molecules as metal chelators for KDM4 inhibition	92
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections	89
Designing halogen-free metal–phenolic imidazolium poly(ionic liquids) with multi-functional antibacterial, anti-inflammatory and cell proliferation properties for infected wounds	77
Beta-cyclodextrin formulation of a disulfide-bond disrupting agent for improved systemic exposure	74
Unveiling sultam in drug discovery: spotlight on the underexplored scaffold	71
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators	70
In vivo demonstration of enhanced mRNA delivery by cyclic disulfide-containing lipid nanoparticles for facilitating endosomal escape	69
Oxadiargyl analogs as potent inhibitors of Toxoplasma gondii protoporphyrinogen oxidase	62
Design, synthesis and structure–activity relationship analysis of dibenzodiazepinone derivatives against Osimertinib resistant NSCLC	44
Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking	43
New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans	43
Unusual Ni⋯Ni interaction in Ni(ii) complexes as potential inhibitors for the development of new anti-SARS-CoV-2 Omicron drugs	42
Exploring the potential of tamoxifen-based copper(ii) dichloride in breast cancer therapy	42
N-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2	39
Design, synthesis, in vitro and in silico evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents	38
The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles	38
ATP-competitive inhibitors for cancer treatment – kinases and the world beyond	37
Effect of mono-guanidine-like derivatives on platelet aggregation and tumour cell induced platelet aggregation	36
Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery	36
Emerging opportunities in the rewiring of biology through proximity inducing small molecules	32
Biocompatible glycolipid derived from bhilawanol as an antibiofilm agent and a promising platform for drug delivery	32

Cytotoxicity of phosphoramidate, bis-amidate and cycloSal prodrug metabolites against tumour and normal cells	31
Integrated computational screen and validation of thalidomide-based PROTACs targeting SARS-CoV-2 main protease	30
Research progress of anticancer drugs targeting CDK12	29
Emerging cellular uptake mechanisms of bRo5 PROTACs	29
Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer	29
Discovery of novel BCAT2 inhibitors: design, synthesis, in vitro evaluation, and molecular modeling studies	28
"Triarylphosphonium-conjugated Sn(IV)-porphyrins for Antimicrobial Photodynamic Therapy: Impact of Substituents on Lipophilicity, Aggregation, and Photoantibacterial Activity"	28
Inside front cover	26
Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles	26
Back cover	25
Simple accessible clemastine fumarate analogues as effective antileishmanials	24
The relationship between cancer risk and cystic fibrosis: the role of CFTR in cell growth and cancer development	23
Design and development of sulfenylated 5-aminopyrazoles as inhibitors of acetylcholinesterase and butyrylcholinesterase: exploring the implication for Aβ 1–42	23
Prodrugs and their activation mechanisms for brain drug delivery	22
Trifluoroacetic acid-mediated synthesis of xanthene constructs and their extensive anti-tuberculosis evaluation	22
Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry	21
Exploration of cytotoxic potential and tubulin polymerization inhibition activity of cis-stilbene-1,2,3-triazole congeners	21
Structure-based design and evaluation of tyrosinase inhibitors targeting both human and mushroom isozymes	21
Design, synthesis and biological evaluation of rhein–piperazine–furanone hybrids as potential anticancer agents	21
Evolution of structure-guided drug design strategies targeting mutations in codon 12 of KRAS	20
Design, synthesis and exploration of cyclic imides as PDE4 inhibitors in psoriasis	20
Structure–activity relationships of fenarimol analogues with potent in vitro and in vivo activity against	20
Design, synthesis and pharmacological evaluation of 3 H -spiro[benzofuran-2,4′-piperidine] IRAK4 inhibitors for the treatment of diffuse large B-cell lym	20
Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review	20
Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying in vivo cardioprotective activities	20
Pretargeted imaging beyond the blood–brain barrier	20
Unravelling the potency of the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile scaffold with S-arylamide hybrids as PIM-1 kinase inhibitors: synthesis, biological activity and in	20
Cornulacin: a new isoflavone from Cornulaca monacantha and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis	19
Investigating the role of cytochrome bd oxidases in the antibacterial activity of madecassic acid and derivatives thereof	19
Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents	19
Radiosynthesis of [ 18 F]brequinar for in vivo PET imaging of hDHODH for potential studies of acute my	19
Bioassay-guided isolation of hepatoprotective lignans from Vernonia cinerea: DeepSAT-driven structural elucidation and predictive mechanistic insights against drug-induced liver injury	19
Natural product-inspired [3 + 2] cycloaddition-based spirooxindoles as dual anticancer agents: synthesis, characterization, and biological evaluation by in vitro and in silico methods	19
Contents list	18
Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6	18
Recent advances from computer-aided drug design to artificial intelligence drug design	18
Beyond acrylamide: a structure-guided investigation of covalent warheads in the development of CDK7 inhibitors	18
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection	18
3-Hydroxypyrimidine-2,4-dione derivatives as monkeypox virus resolvase (Mpr) inhibitors	17
Water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines for G4-targeting photodynamic therapy	17
On-resin synthesis of Lanreotide epimers and studies of their structure–activity relationships	17
The physics-AI dialogue in drug design	17
Front cover	17
It's ok to be outnumbered – sub-stoichiometric modulation of homomeric protein complexes	17
Contents list	17
Front cover	17
The allure of targets for novel drugs	16
Correction: Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus	16
Design, synthesis and evaluation of 2-phenylpyrimidine derivatives as novel antifungal agents targeting CYP51	16
Design, synthesis and anti-proliferative activity of 3-aryl-evodiamine derivatives	16

Rutaecarpine derivatives synthesized via skeletal reorganization alleviate inflammation-associated oxidative damage by inhibiting the MAPK/NF-κB signaling pathway	16
Synthesis of novel rapanone derivatives via organocatalytic reductive C-alkylation: biological evaluation of antioxidant properties, in vivo zebrafish embryo toxicity, and docking studie	16
Developing pyrazole–oxadiazole conjugates as potent anti-tubercular agents: an in silico and in vitro appr	16
An allosteric inhibitor targeting the STAT3 coiled-coil domain selectively suppresses proliferation of breast cancer	16
SETDB1 as a cancer target: challenges and perspectives in drug design	16
Back cover	16
Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water	16
The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition	16
Recent advances towards BACE1 drug discovery and therapeutics design	15
Glioblastoma antitumoral activity of tetrahydroquinoline-derived triarylmethanes	15
Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry	15
Can large language models predict antimicrobial peptide activity and toxicity?	15
Recent advancements in the development of next-generation dual-targeting antibacterial agents	15
Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction	15
Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis	15
Proximity-induced membrane protein degradation for cancer therapies	15
Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation	15
Inhibition of transcription and antiproliferative effects in a cancer cell line using antigene oligonucleotides containing artificial nucleoside analogues	14
From fragments to follow-ups: rapid hit expansion by making use of EU-OPENSCREEN resources	14
Druggable targets for the immunopathy of Alzheimer's disease	14
Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication	14
Stereochemical optimization of N ,2-substituted cycloalkylamines as norepinephrine reuptake inhibitors	14
Harnessing carlina oxide scaffold for the management of vector-borne diseases: synthesis and structure–activity relationship	14
Synthesis and biological evaluation of thiosemicarbazone-based antibody–drug conjugates	14
Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties	14
Development of Hsp90 C-terminal inhibitors with noviomimetics that manifest anti-proliferative activities	14
Discovery of GBA-16-24 as a highly potent, selective ATR inhibitor for the treatment of FLT3-mutated acute myeloid leukemia	13
NMR 1H,19F-based screening of the four stem-looped structure 5_SL1–SL4 located in the 5′-untranslated region of SARS-CoV 2 RNA	13
Contents list	13
Recent advancements in the therapeutic approaches for Alzheimer's disease treatment: current and future perspective	13
Hinokitiol potentiates antimicrobial activity of bismuth drugs: a combination therapy for overcoming antimicrobial resistance	13
In vitro and in vivo studies of dehydroxylated-isoquines and -isotebuquines against trypanosomatids: a preclinical drug candid	13
Sulfone and sulfoxide-containing pharmaceuticals: targets, pharmacological properties and SAR studies	13
Back cover	13
Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma	13
Novel rhodanine–thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach	13
The importance of tyrosines in multimers of cyclic RGD nonapeptides: towards αvβ6-integrin targeted radiotherapeutics	13
Inside front cover	13
Quinazolinone-1,2,3-triazole-acetamide conjugates as potent α-glucosidase inhibitors: synthesis, enzyme inhibition, kinetic analysis, and molecular docking study	12
Contents list	12
Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation	12
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes	12
Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding	12
Peptides as multifunctional linchpins in targeted drug conjugates	12
Inside front cover	12
Site-specific molecular glues for the 14-3-3/Tau pS214 protein–protein interaction via reversible covalent imine tethering	12
Novel glycine amides, semicarbazides and fluoroallylamines as inhibitors of the amine oxidase vascular adhesion protein-1 (VAP-1)	12
Synthesis and evaluation of HFIP bearing triazolo-amides as amyloid-β aggregation inhibitors and suppressors of aggregation induced neuroinflammation	12
SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway	12
On the history, synthesis, and medicinal use of cantharidin, LB-100, and their analogs	12
“Seasoning” antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits	12
Identification of novel phenylalanine derivatives bearing a hydroxamic acid moiety as potent quorum sensing inhibitors	12
Progress in the discovery and development of small molecule methuosis inducers	12
Design, synthesis, and biological evaluation of novel thiazole derivatives as PI3K/mTOR dual inhibitors	12
Development of a nitric oxide-releasing cephalexin-based hybrid compound for enhanced antimicrobial efficacy and biofilm disruption	12
Outstanding Reviewers for RSC Medicinal Chemistry in 2024	11
Back cover	11
Synthesis and investigation of thieno[2,3-b]pyridines that restore activity of topotecan	11
Back cover	11
Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, in vitro and in vivo anti-diabetic evaluation	11
Inside front cover	11
Diversifying the triquinazine scaffold of a Janus kinase inhibitor	11
Anticancer potential of copper(i) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands	11
Adjuvant strategies to tackle mcr -mediated polymyxin resistance	11
Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant Staphylococcus aureus and	11
Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage	11
Development of thiazole-appended novel hydrazones as a new class of α-amylase inhibitors with anticancer assets: anin silicoandin vitroapproach	11
Guggulsterone – a potent bioactive phytosteroid: synthesis, structural modification, and its improved bioactivities	11
Novel lithocholic acid-diindolylmethane hybrids as potent sialyltransferase inhibitors targeting triple-negative breast cancer: a molecular hybridization approach	11
Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors	11
Contents list	11
Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer	11
Five years of research on 2,4-thiazolidinediones as anticancer agents: medicinal chemistry insights (2020–2024)	11
Discovery of a potent and selective PROTAC degrader for STAT3	11
Research progress of metal–organic framework nanozymes in bacterial sensing, detection, and treatment	11
The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif	11
Synthesis and antiplasmodial activity of 6H,13H-pyrazino[1,2-a;4,5-a′]diindole analogues substituted with basic side chains	11
Lysine targeting covalent inhibitors of malarial kinase Pf CLK3	11
Design and synthesis of novel cathepsin C inhibitors with anti-inflammatory activity	11
Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity	11

Fragment-based discovery of dual ligand pharmacophores for lipid-sensing transcription factors for designed polypharmacology	11
Contents list	11
Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates	11
Extending the architecture of bolaamphiphilic disinfectants: an investigation of octenidine and isooctenidine analogs	11
Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting	10
Complexity of αvβ6-integrin targeting RGD peptide trimers: emergence of non-specific binding by synergistic interaction	10
Endoperoxide delivered singlet oxygen: the future of PDT, without light or oxygen	10
Contents list	10
Contents list	10
Cyclometalated complexes: promising metallodrugs in the battle against cancer	10
Distinctive roles of aquaporins and novel therapeutic opportunities against cancer	10
Development of trisubstituted thiophene-3-arboxamide selenide derivatives as novel EGFR kinase inhibitors with cytotoxic activity	10
Molecular understanding of the therapeutic potential of melanin inhibiting natural products	10
Inhibition of bacterial RNA polymerase function and protein–protein interactions: a promising approach for next-generation antibacterial therapeutics	10
Design, synthesis and biological evaluation of novel β-caryophyllene derivatives as potential anti-cancer agents through the ROS-mediated apoptosis pathway	10
Introduction to the themed collection in honour of Professor Christian Leumann	10
Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs	10
Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure–activity relationship enabling the swi	10
AlbiCDN: albumin-binding amphiphilic STING agonists augment the immune activity for cancer immunotherapy	10
Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches	10
EGFR AP : a predictive machine learning model for assessing small molecule activity against the epidermal growth factor receptor	10
Front cover	10
Contents list	10
Front cover	10
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation	10
Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance	10
The rise of ultrashort cationic β-peptides as promising antimicrobial therapeutics	9
Applications of supramolecular assemblies in drug delivery and photodynamic therapy	9
Synthesis and evaluation of tetrahydropyrrolo[1,2- a ]quinolin-1(2 H )-ones as new tubulin polymerization	9
NLRP3 inflammasome: structure, mechanism, drug-induced organ toxicity, therapeutic strategies, and future perspectives	9
Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response	9
Contents list	9
Design, synthesis, and biological evaluation of sulfonamide-functionalized pyridine carbothioamides as potent tubulin-targeting anticancer agents	9
Design, synthesis, antimicrobial activity, stability, and mechanism of action of bioresorbable ceragenins	9
Design, synthesis, molecular docking and anti-proliferative activity of novel phenothiazine containing imidazo[1,2-a]pyridine derivatives against MARK4 protein	9
Front cover	9
QSAR, structure-based pharmacophore modelling and biological evaluation of novel platelet ADP receptor (P2Y12) antagonist	9
Expanding the chemical space for antiviral discovery: the potential of twistenediones	9
Polysucrose hydrogel loaded with natural molecules/extracts for multiphase-directed sustainable wound healing	9
Introduction to the themed collection on ‘Targeting RNA with small molecules’	9
Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site	9
Lead optimization of 5jc21 (CG13250), a quinolin-2(1 H )-one-based inhibitor of the BRD4 member of the bro	9
Novel benzimidazole hybrids: design, synthesis, mechanistic studies, antifungal potential and molecular dynamics	9
Expanding the structure–activity relationships of alkynyl diphenylurea scaffold as promising antibacterial agents	9
Discovery of selective, metabolically stable pyrazole-based FLT3 inhibitors for the treatment of acute myeloid leukemia	9
Copper selective 8-aminoquinoline based tetradentate chelators as anticancer agents	9
Analysis of the structural diversity of heterocycles amongst European medicines agency approved pharmaceuticals (2014–2023)	9
The Mycobacterium tuberculosis mycothiol S-transferase is divalent metal-dependent for mycothiol binding and transfer	9
Recent advances in structural modifications of natural products for anti-leishmaniasis therapy (2010–2024)	9
Inside front cover	9
Correction: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody–drug conjugate properties	9
Design of chitosan-coated CeO 2 -doped ZnCr LDO nanocomposites for optimized azithromycin delivery: a kinetic and mechanistic perspective	9
Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents	9
Stereoselective synthesis and antiproliferative activity of allo-gibberic acid-based 1,3-aminoalcohol regioisomers	9
Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity	9
Decoding the association of polycystic ovary syndrome with metabolic-associated fatty liver: insights into CK18 and LC3II/ATG7/P62 autophagy axis and adjunct therapeutics of metformin and levothyroxin	9
Front cover	9
Novel pirfenidone derivatives: synthesis and biological evaluation	9
Macrocyclic RGD-peptides with high selectivity for α v β 3 integrin in cancer imaging and therapy	9
Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7–Lin28 RNA–protein interaction	9
Contents list	9
Computer-aided discovery of triazolothiadiazoles as DYRK1A-targeted neuroprotective agents	9
Machine learning prediction of acute toxicity with in vivo experiments on tetrazole derivatives	8
Lactose-conjugated 2-iminothiazolidin-4-ones: synthesis, inhibitory activity and molecular simulations as potential inhibitors against enzymes responsible for type 2 diabetes	8
Design and synthesis of coumarin-based amphoteric antimicrobials with biofilm interference and immunoregulation effects	8
From traditional medicine to nanomedicine: potential of Ginkgo biloba extracts in treating inflammatory skin diseases	8
Back cover	8
Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors	8
Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity	8
Inside front cover	8
Enhanced skin penetration of curcumin by a nanoemulsion-embedded oligopeptide hydrogel for psoriasis topical therapy	8
Development, biological evaluation, and molecular modelling of novel isocytosine and guanidine derivatives as BACE1 inhibitors using a fragment growing strategy	8
Heterocyclic compounds as xanthine oxidase inhibitors for the management of hyperuricemia: synthetic strategies, structure–activity relationship and molecular docking studies (2018–2024)	8
Synthesis and properties of the kojic acid dimer and its potential for the treatment of Alzheimer's disease	8
Antitubercular evaluation of dihydropyridine–triazole conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions	8
LLDT-8 attenuates brain metastasis in non-small cell lung cancer via selective p53 activation	8
Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates	8
Phenylthiazoles with potent & optimum selectivity toward Clostridium difficile	8
Contents list	8
Discovery of novel dehydroabietylamine–pyrimidine hybrids: design, synthesis and anti-tumor evaluation	8
Tanshinones target drug-resistant tuberculosis: efficacy, selectivity, and potential mechanism of action	8
Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole–nicotinamide chemotype	8
Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein	8
Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity	8
Exploring medium and long arm extensions of 1,2,4-triazole derivatives as Candida albicans 14α-demethylase (CYP51) inhibitors	8
The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease	8
Overview of CFTR activators and their recent studies for dry eye disease: a review	8
Contents list	8
Front cover	8
Mannich reaction mediated derivatization of chromones and their biological evaluations as putative multipotent ligands for the treatment of Alzheimer's disease	8
In vitro evaluation of the immunogenic potential of gramicidin S and its photocontrolled analogues	8
Development of pharmacophore models for AcrB protein and the identification of potential adjuvant candidates for overcoming efflux-mediated colistin resistance	8
Discovery of first-in-class PROTACs targeting maternal embryonic leucine zipper kinase (MELK) for the treatment of Burkitt lymphoma	8
Screening apelin analogues and a small molecule agonist as effective cardiovascular therapeutics against reperfusion injury	8
Design, synthesis, inhibitory activity, and molecular simulations study for d-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosid	8