RSC Medicinal Chemistry

Article	Citations
Put a ring on it: application of small aliphatic rings in medicinal chemistry	166
Macrocyclization strategies for cyclic peptides and peptidomimetics	74
Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis	73
Repurposing the HCV NS3–4A protease drug boceprevir as COVID-19 therapeutics	56
β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates	54
Recent developments on MOF-based platforms for antibacterial therapy	51
Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies	49
Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors	46
Target 2035 – update on the quest for a probe for every protein	39
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors	38
A review of the latest research on Mpro targeting SARS-COV inhibitors	37
Fragment-based drug discovery: opportunities for organic synthesis	35
Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase	31
β-Carboline-based molecular hybrids as anticancer agents: a brief sketch	30
Recent advances in the development of covalent inhibitors	30
Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase	28
Polarity-based fluorescence probes: properties and applications	27
Ruthenium(ii)–arene complexes as anti-metastatic agents, and related techniques	27
Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides	23
Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives	22
Normal breast epithelial MCF-10A cells to evaluate the safety of carbon dots	21
Human carboxylesterases and fluorescent probes to image their activity in live cells	21
Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs	21
Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers	21
Medicinal chemistry updates on quinoline- and endoperoxide-based hybrids with potent antimalarial activity	21

Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies	21
Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses	20
Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?	19
Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?	19
Covalent PROTACs: the best of both worlds?	19
A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU/NSP15): in silico and in vitro investigations	18
Natural product-informed exploration of chemical space to enable bioactive molecular discovery	17
Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors	17
Selective degradation-inducing probes for studying cereblon (CRBN) biology	17
Chemical modulation of Kv7 potassium channels	16
Design, synthesis, and antibacterial activity ofN-(trifluoromethyl)phenyl substituted pyrazole derivatives	16
Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (MPRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model	16
Collaborative virtual screening to elaborate an imidazo[1,2-a]pyridine hit series for visceral leishmaniasis	16
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics	16
Advances in research on 3C-like protease (3CLpro) inhibitors against SARS-CoV-2 since 2020	15
The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria	15
Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles	15
Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues	15
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors	15
The era of high-quality chemical probes	15
Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents	14
In vitroandin vivosigma 1 receptor imaging studies in different disease states	14
Analysis of physicochemical properties of protein–protein interaction modulators suggests stronger alignment with the “rule of five”	13
Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators	13
Siderophore conjugates to combat antibiotic-resistant bacteria	13
Deglycase-activity oriented screening to identify DJ-1 inhibitors	12
Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation	12
Covalent drugs targeting histidine – an unexploited opportunity?	12
Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents	12
Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN	12
Recent advances in the development of AHR antagonists in immuno-oncology	12
Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity	12
Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity	12
Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA	12
Antibacterial activities of plant-derived xanthones	12
Current leishmaniasis drug discovery	12
Nitriles: an attractive approach to the development of covalent inhibitors	11
Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives	11
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors	11
Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions	11
Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis	11
Morpholine substituted quinazoline derivatives as anticancer agents against MCF-7, A549 and SHSY-5Y cancer cell lines and mechanistic studies	11
A ‘click’ chemistry approach to novel entinostat (MS-275) based class I histone deacetylase proteolysis targeting chimeras	11
Formulation and clinical translation of [177Lu]Lu-trastuzumab for radioimmunotheranostics of metastatic breast cancer	11
Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo[1,5-a]pyrimidine scaffold	11
Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks	11
Recent developments of imidazo[1,2-a]pyridine analogues as antituberculosis agents	11
Structure–activity relationships of valine, tert-leucine, and phenylalanine amino acid-derived synthetic cannabinoid receptor agonists related to ADB-BUTINACA, APP-BUTINACA, and ADB-P7AICA	11
Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analogues	11
Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1	10

Comprehensive analysis of commercial fragment libraries	10
Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers	10
Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties	10
Pretargeted imaging beyond the blood–brain barrier	10
Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism	10
Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders	10
Design and synthesis of eugenol/isoeugenol glycoconjugates and other analogues as antifungal agents against Aspergillus fumigatus	10
Synthesis and immunological evaluation ofN-acyl modified Globo H derivatives as anticancer vaccine candidates	10
CDK9 inhibitors in cancer research	10
Mechanisms and inhibitors of nicotinamide N-methyltransferase	10
Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors	10
PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery	10
Monobodies as tool biologics for accelerating target validation and druggable site discovery	10
Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo	10
Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease	10
Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors	10
Synthesis of low-molecular weight fucoidan derivatives and their binding abilities to SARS-CoV-2 spike proteins	9
Peptide-based positron emission tomography probes: current strategies for synthesis and radiolabelling	9
Pharmacological inhibition of NF-κB-inducing kinase (NIK) with small molecules for the treatment of human diseases	9
SF5- and SCF3-substituted tetrahydroquinoline compounds as potent bactericidal agents against multidrug-resistant persister Gram-positive bacteria	9
Proline pre-conditioning of cell monolayers increases post-thaw recovery and viability by distinct mechanisms to other osmolytes	9
Replacement of oxygen with sulfur on the furanose ring of cyclic dinucleotides enhances the immunostimulatory effect via STING activation	9
Expanding the repertoire of methanocarba nucleosides from purinergic signaling to diverse targets	9
Amino alcohol acrylonitriles as broad spectrum and tumour selective cytotoxic agents	9
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance	9
Bifunctional chelators for radiorhenium: past, present and future outlook	9
Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe	9
Profiling MAP kinase cysteines for targeted covalent inhibitor design	9
Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach	8
Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram	8
NIR-II imaging of hepatocellular carcinoma based on a humanized anti-GPC3 antibody	8
Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties	8
Phthalimide analogs for antimalarial drug discovery	8
Natural-product-based fluorescent probes: recent advances and applications	8
Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs	8
Molecular dynamics: a powerful tool for studying the medicinal chemistry of ion channel modulators	8
Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay	8
An overview of the development of EED inhibitors to disable the PRC2 function	8
The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification	8
Anticancer evaluation of new organometallic ruthenium(ii) flavone complexes	8
4-Amino-1,8-naphthalimide–ferrocene conjugates as potential multi-targeted anticancer and fluorescent cellular imaging agents	8
Cyclisation strategies for stabilising peptides with irregular conformations	8
It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity	8
A story of peptides, lipophilicity and chromatography – back and forth in time	7
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A	7
Will the chemical probes please stand up?	7
The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, S	7
VISTA inhibitors in cancer immunotherapy: a short perspective on recent progresses	7
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives	7
Structure–activity relationships of hydrophobic alkyl acrylamides as tissue transglutaminase inhibitors	7
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set	7
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells	7
FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms	7
Synthesis and evaluation of triazole congeners of nitro-benzothiazinones potentially active against drug resistant Mycobacterium tuberculosis demonstrating bactericidal efficacy	7
A niclosamide–tobramycin hybrid adjuvant potentiates cefiderocol againstP. aeruginosa	7
A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti	7
Overview of the structure, side effects, and activity assays of l-asparaginase as a therapy drug of acute lymphoblastic leukemia	7
Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint	7
Recent applications of covalent chemistries in protein–protein interaction inhibitors	7
De novo molecular drug design benchmarking	7
Synthesis and pharmacological evaluation of [18F]PBR316: a novel PET ligand targeting the translocator protein 18 kDa (TSPO) with low binding sensitivity to human single nucleotide polymorp	7
Uptake mechanisms of cell-internalizing nucleic acid aptamers for applications as pharmacological agents	7
Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella	7
Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents	7
Identification of molecular glues of the SLP76/14-3-3 protein–protein interaction	6
Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells	6
Evaluation of the effect of a cell penetrating peptide (TAT) towards tailoring the targeting efficacy and tumor uptake of porphyrin	6
Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy	6
Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators	6
The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery	6
Targeting the protease of West Nile virus	6
Modulating β-arrestin 2 recruitment at the δ- and μ-opioid receptors using peptidomimetic ligands	6
New perspectives in cancer drug development: computational advances with an eye to design	6
Antibiotic administration in targeted nanoparticles protects the faecal microbiota of mice	6
Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeability	6
Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications	6
An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases	6
Oxazolidinones as versatile scaffolds in medicinal chemistry	6
Structure–activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents	6
Assessment of the rules related to gaining activity against Gram-negative bacteria	6

Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking	6
Advanced approaches of developing targeted covalent drugs	6
Piperazine tethered bergenin heterocyclic hybrids: design, synthesis, anticancer activity, and molecular docking studies	6
N-1,2,3-Triazole–isatin derivatives: anti-proliferation effects and target identification in solid tumour cell lines	6
Assessing the mechanisms of action of natural molecules/extracts for phase-directed wound healing in hydrogel scaffolds	6
Pharmacokinetics and pharmacodynamics in the treatment of cutaneous leishmaniasis – challenges and opportunities	6
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa	6
Using membrane perturbing small molecules to target chronic persistent infections	6
Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as TRK inhibitors	6
Introducing the metacore concept for multi-target ligand design	5
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents	5
Rational design of selective inhibitors of PARP4	5
Metabolic labelling of cancer cells with glycodendrimers stimulate immune-mediated cytotoxicity	5
Progress in mechanistically novel treatments for schizophrenia	5
Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy	5
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation	5
Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors	5
Antibacterial activities of anthraquinones: structure–activity relationships and action mechanisms	5
Integrating a covalent probe with ubiquicidin fragment enables effective bacterial infection imaging	5
Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C	5
Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies	5
Red light active Pt(iv)–BODIPY prodrug as a mitochondria and endoplasmic reticulum targeted chemo-PDT agent	5
A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors	5
Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit	5
Synthesis and bioactive evaluation of N-((1-methyl-1H-indol-3-yl)methyl)-N-(3,4,5-trimethoxyphenyl)acetamide derivatives as agents for inhibiting tubulin polymerization	5
Novel fluorinated ring-fused chlorins as promising PDT agents against melanoma and esophagus cancer	5
2-Difluoromethylpyridine as a bioisosteric replacement of pyridine-N-oxide: the case of quorum sensing inhibitors	4
The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors	4
SAR study of 4-arylazo-3,5-diamino-1H-pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms	4
Synthesis of tryptanthrin appended dispiropyrrolidine oxindoles and their antibacterial evaluation	4
Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding	4
Expanding the scope of novel 1,2,3-triazole derivatives as new antiparasitic drug candidates	4
Photochemical synthesis of an epigenetic focused tetrahydroquinoline library	4
Synthesis and biological evaluation of N6 derivatives of 8-azapurine as novel antiplatelet agents	4
Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains	4
Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR	4
Identification of ligand linkage vectors for the development of p300/CBP degraders	4
Hydroxypyrone derivatives in drug discovery: from chelation therapy to rational design of metalloenzyme inhibitors	4
Generation of reactive oxygen species is the primary mode of action and cause of survivin suppression by sepantronium bromide (YM155)	4
Discovery of antipsychotic loxapine derivatives against intracellular multidrug-resistant bacteria	4
Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6	4
Scaffold hopping from indoles to indazoles yields dual MCL-1/BCL-2 inhibitors from MCL-1 selective leads	4
Novel irreversible peptidic inhibitors of transglutaminase 2	4
Designed hybrid anticancer nuclear-localized peptide inhibits aggressive cancer cell proliferation	4
Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds	4
Synthesis of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins	4
Structure–activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase	4
Stereoisomeric Pam2CS based TLR2 agonists: synthesis, structural modelling and activity as vaccine adjuvants	4
Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2	4
Deacylcortivazol-like pyrazole regioisomers reveal a more accommodating expanded binding pocket for the glucocorticoid receptor	4
Host–guest binding of tetracationic cyclophanes to photodynamic agents inhibits posttreatment phototoxicity and maintains antitumour efficacy	4
Encoding BRAF inhibitor functions in protein degraders	4
A concise review on hPXR ligand-recognizing residues and structure-based strategies to alleviate hPXR transactivation risk	4
Antiproliferative activity and toxicity evaluation of 1,2,3-triazole and 4-methyl coumarin hybrids in the MCF7 breast cancer cell line	4
Efficient selective targeting of Candida CYP51 by oxadiazole derivatives designed from plant cuminaldehyde	4
Targeted protein degradation using the lysosomal pathway	4
ItaCORMs: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates	4
Design, synthesis and biological evaluation of light-driven on–off multitarget AChE and MAO-B inhibitors	4
Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A	4
Multi-target antibacterial mechanism of ruthenium polypyridine complexes with anthraquinone groups againstStaphylococcus aureus	3
Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action	3
Current status and prospects of MIL-based MOF materials for biomedicine applications	3
Structural modifications that increase gut restriction of bile acid derivatives	3
The role of small molecules in cell and gene therapy	3
Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors	3
Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine	3
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series	3
Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors	3
Development of 2-deoxystreptamine–nucleobase conjugates for the inhibition of oncogenic miRNA production	3
First-in-class small molecule inhibitors of ICOS/ICOSL interaction as a novel class of immunomodulators	3
Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant Staphylococcus aureus and	3
Site-directed late-stage diversification of macrocyclic nannocystins facilitating anticancer SAR and mode of action studies	3
Synthesis and structure–activity relationships of pirfenidone derivatives as anti-fibrosis agents in vitro	3
Novel tetrahydropyrimidinyl-substituted benzimidazoles and benzothiazoles: synthesis, antibacterial activity, DNA interactions and ADME profiling	3
De novodesign of a stapled peptide targeting SARS-CoV-2 spike protein receptor-binding domain	3
Antioxidant mechanisms and products of four 4′,5,7-trihydroxyflavonoids with different structural types	3
Reactivity of N-acyl hydrazone probes with the mammalian proteome	3
An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives	3
Copper chelating cyclic peptidomimetic inhibits Aβ fibrillogenesis	3
Exploration of cytotoxic potential and tubulin polymerization inhibition activity of cis-stilbene-1,2,3-triazole congeners	3
Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies	3
Inhibition of NaV1.7: the possibility of ideal analgesics	3
Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance	3
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor	3
Antileishmanial evaluation of triazole–butenolide conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions	3
Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria	3
Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity	3
Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits	3
Design, synthesis and antibacterial evaluation of a novel class of tetrahydrobenzothiophene derivatives	3
Introduction to the themed collection on fragment-based drug discovery	3
Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry	3
Biphenyl scaffold for the design of NMDA-receptor negative modulators: molecular modeling, synthesis, and biological activity	3
The identification of highly efficacious functionalised tetrahydrocyclopenta[c]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly	3
Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity	3
Design, synthesis, and biological evaluation of C6-difluoromethylenated epoxymorphinan Mu opioid receptor antagonists	3