OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Pharmaceutics-X is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice	95
Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges	43
HSPiP and QbD oriented optimized nanocubosomes for ameliorated absorption of tolterodine tartrate: In vitro and in vivo evaluations	29
Tailored transethosomal systems for tadalafil transdermal delivery: Impact of Phosal and edge activators on skin permeation and cellular uptake	26
Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics	24
Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition	21
Tailored ASD destabilization - Balancing shelf life stability and dissolution performance with hydroxypropyl cellulose	20
Enabling formulations of aprepitant: in vitro and in vivo comparison of nanocrystalline, amorphous and deep eutectic solvent based formulations	20
Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals	17
Enhancing oocyte in vitro maturation and quality by melatonin/bilirubin cationic nanoparticles: A promising strategy for assisted reproduction techniques	16
Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications	16
Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process	15
Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug degradation and crystallinity	14
Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors	14
Erratum regarding missing Conflict of Interest statements in previously published articles	14
Exploring bioadhesion: insight on innovative strategies to investigate bioadhesive scaffolds	12
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin	12
Synergistic photodynamic and chemodynamic therapy using hypoxia-adaptive Ce6@Co nanoparticles for enhanced tumor suppression	12
Modeling of physical-mechanical and microbiological properties of tablets made of complex fluidized bed granules containing living yeast cells using common mixing rules	12
Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons	12
Construction and applications of exosome-microneedle integrated systems	12
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation	11
Polycaprolactone – Vitamin E TPGS micelles for delivery of paclitaxel: In vitro and in vivo evaluation	11
Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology	11
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets	11

Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery	11
Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion	11
RETRACTED: Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutics:X Volume	11
A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying	10
Corrigendum to “Quantitative comparison of the protein corona of nanoparticles with different matrices” [Int J Pharm X 2022 Oct 21;4: 100136]	10
A blood-brain barrier-penetrating nanoreactor for tumor microenvironment modulation, precise MR imaging and synergistic therapy of glioma	10
Editorial Board	10
MgZnFe-layered double hydroxides as a dual-function platform for enhancing subunit vaccine efficacy in tumor immunotherapy	10
A novel EGFR-targeted photosensitizer for the theranostics of skin cancer	10
Iontophoretic delivery of caspofungin acetate to the cornea and sclera and its intracorneal biodistribution	10
Predicting pharmaceutical inkjet printing outcomes using machine learning	9
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia	9
Preparation and in vitro property evaluation of NO-HA@ICG self-assembled nanoparticles for gas therapy synergized with phototherapy	9
Formulation, in silico, in vitro characterization, cytotoxicity and cellular uptake of cyclodextrin complexes and ion pairing/salt formation with functional excipients (azelaic acid, tartaric acid, an	8
A new engineering process of biodegradable polymeric solid implants for ultra-long-acting drug delivery	8
A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process	8
Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide	8
A network of regulatory innovations to improve FDA quality assessments of human drug applications	8
Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat	8
Preservative-free electrospun nanofibrous inserts for sustained delivery of ceftazidime; design, characterization and pharmacokinetic investigation in rabbit's eye	8
Life cycle assessment of pharmaceutical tablet manufacturing: A comparative analysis and systems model integration framework	7
Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cel	7
A model-based optimization strategy to achieve fast and robust freeze-drying cycles	7
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions	7
Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis	7
Does the appearance of the Magenstrasse depend on the amount of water consumed?	7
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell li	7
Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation	7
Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma	7
Glucose-functionalized redox-responsive dihydroartemisinin prodrug nanosystem for targeted malaria therapy	7
Comparative evaluation of ternary amorphous solid dispersions: Identifying optimal excipient systems for enhancing drug solubility	7
Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies	7
Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal	7
The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little	6
Fucoidan/Polyvinylpyrrolidone/Hesperitin nanoparticle complex for corneal injury treatment: Synthesis, characterization, and therapeutic efficacy	6
Comparative study on two kinds of brain-targeted liposomes co-modified by RVGP and R9 in different ways	6
Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled release	6
HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations	6
Editorial board	6
CD276-directed supramolecular nanoplatform with pH-triggered gemcitabine release for potent tumor stromal and vascular suppression	6
Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and tr	6
Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning	6
Plant-derived extracellular vesicles as a natural drug delivery platform for glioblastoma therapy: A dual role in preserving endothelial integrity while modulating the tumor microenvironment	5
Optimizing microRNA delivery via albumin-decorated nanostructured lipid carriers	5
Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment	5
Extraction of the polysorbate 20 and 80 fingerprint via generative modeling	5
How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up	5
Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy	5
Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation	5
RETRACTED: Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-v	5

Revolutionary hyaluronic acid-modified edge-activated spanlastics as a novel approach to boost Hepatoprotective activity of Curcumin: Optimization, biochemical analysis and in-vivo assessment	5
Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications	5
Development of a potential nano-based delivery system combining Colchicine-loaded lipid nanocapsules and BIOT-NFL-peptide to target glioblastoma	5
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimizat	5
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation	5
Oxidation of polysorbates – An underestimated degradation pathway?	5
Nebulized macrophage membrane-engineered triptolide liposomes for Siglec-10/CD24-mediated therapeutic targeting in lung cancer	5
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications	5
Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy	5
Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings	5
Targeted probiotic tabletting: A hybrid active learning and finite element modelling approach for process optimisation	5
Retraction notice to “Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutic	5
RP-HPLC-CAD method for the rapid analysis of lipids used in lipid nanoparticles derived from dual centrifugation	5
Advanced microfluidic techniques for the preparation of solid lipid nanoparticles: Innovations and biomedical applications	5
Biomimetic nanotherapy for P. gingivalis-infected oral squamous cell carcinoma: Photothermal therapy and immunoactivation via precise intracellular bacterial elimination	4
Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells	4
Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through in vivo expression	4
The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation proce	4
Modelling intramuscular drug fate in vitro with tissue-relevant biomimetic hydrogels	4
Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma	4
Developments in image-based colorimetric analysis methods and applications of CIElab color space in pharmaceutical sciences: A narrative review	4
Release mechanisms of PLGA microparticles prepared using a microfluidics device or a beaker	4
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending	4
Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions	4
Liposomal glytrexate formulation: improving antitumour efficacy and minimizing toxicity in breast cancer therapy	4
WITHDRAWN: The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating	4
The use of heat to deliver fentanyl via pulmonary drug delivery	4
M1 macrophage-membrane-cloaked paclitaxel/β-elemene nanoparticles targeting cervical cancer for enhanced therapy	4
A single oral administration of resveratrol cocrystals enables potent antisepsis therapy via interfering neutrophil extracellular traps formation	4
Functional candesartan loaded lipid nanoparticles for the control of diabetes-associated stroke: In vitro and in vivo studies	4
The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing	4
Co-assembled Glycyrrhiza nanoparticles embedded supramolecular protein hydrogels to enhance licochalcone A release for acute inflammation management	4
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin	4
pH-responsive polymeric nanoparticles for peptide delivery: Synergistic STING pathway activation enhances tumor immunotherapy	4
Release mechanisms of PLGA-based drug delivery systems: A review	4
Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study	4
Optimized buccoadhesive repaglinide-loaded cubogel: In-vitro characterization and in-vivo hypoglycemic activity in a streptozotocin-induced diabetic rat model	4
Hypoxia-responsive Exatecan prodrug liposomes co-delivered with IR808 for synergistic chemo–photodynamic therapy of breast cancer	4
Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy	4