OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Pharmaceutics-X is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice	100
Tailored ASD destabilization - Balancing shelf life stability and dissolution performance with hydroxypropyl cellulose	31
Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics	26
Tailored transethosomal systems for tadalafil transdermal delivery: Impact of Phosal and edge activators on skin permeation and cellular uptake	24
HSPiP and QbD oriented optimized nanocubosomes for ameliorated absorption of tolterodine tartrate: In vitro and in vivo evaluations	21
Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications	20
Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges	17
Engineering exosomes for cancer therapy - Modification technologies and subcellular targeting strategies: A review	16
Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals	16
Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors	15
Erratum regarding missing Conflict of Interest statements in previously published articles	15
Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process	15
Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons	15
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation	15
Modeling of physical-mechanical and microbiological properties of tablets made of complex fluidized bed granules containing living yeast cells using common mixing rules	15
Exploring bioadhesion: insight on innovative strategies to investigate bioadhesive scaffolds	12
Enhancing oocyte in vitro maturation and quality by melatonin/bilirubin cationic nanoparticles: A promising strategy for assisted reproduction techniques	12
Construction and applications of exosome-microneedle integrated systems	12
Synergistic photodynamic and chemodynamic therapy using hypoxia-adaptive Ce6@Co nanoparticles for enhanced tumor suppression	12
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin	12
Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery	11
Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion	11
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets	11
RETRACTED: Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutics:X Volume	10
Polycaprolactone – Vitamin E TPGS micelles for delivery of paclitaxel: In vitro and in vivo evaluation	10

A blood-brain barrier-penetrating nanoreactor for tumor microenvironment modulation, precise MR imaging and synergistic therapy of glioma	10
A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying	10
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia	10
MgZnFe-layered double hydroxides as a dual-function platform for enhancing subunit vaccine efficacy in tumor immunotherapy	10
Predicting pharmaceutical inkjet printing outcomes using machine learning	9
A novel EGFR-targeted photosensitizer for the theranostics of skin cancer	9
Editorial Board	9
Corrigendum to “Quantitative comparison of the protein corona of nanoparticles with different matrices” [Int J Pharm X 2022 Oct 21;4: 100136]	9
A model-based optimization strategy to achieve fast and robust freeze-drying cycles	8
A network of regulatory innovations to improve FDA quality assessments of human drug applications	8
Formulation, in silico, in vitro characterization, cytotoxicity and cellular uptake of cyclodextrin complexes and ion pairing/salt formation with functional excipients (azelaic acid, tartaric acid, an	8
Preparation and in vitro property evaluation of NO-HA@ICG self-assembled nanoparticles for gas therapy synergized with phototherapy	8
Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat	8
Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide	8
Iontophoretic delivery of caspofungin acetate to the cornea and sclera and its intracorneal biodistribution	8
Does the appearance of the Magenstrasse depend on the amount of water consumed?	7
Glucose-functionalized redox-responsive dihydroartemisinin prodrug nanosystem for targeted malaria therapy	7
Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cel	7
Life cycle assessment of pharmaceutical tablet manufacturing: A comparative analysis and systems model integration framework	7
Preservative-free electrospun nanofibrous inserts for sustained delivery of ceftazidime; design, characterization and pharmacokinetic investigation in rabbit's eye	7
A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process	7
Comparative evaluation of ternary amorphous solid dispersions: Identifying optimal excipient systems for enhancing drug solubility	7
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell li	7
Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies	6
Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and tr	6
Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning	6
Editorial board	6
Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis	6
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions	6
Fucoidan/Polyvinylpyrrolidone/Hesperitin nanoparticle complex for corneal injury treatment: Synthesis, characterization, and therapeutic efficacy	6
CD276-directed supramolecular nanoplatform with pH-triggered gemcitabine release for potent tumor stromal and vascular suppression	6
HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations	6
Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation	6
Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma	6
Comparative study on two kinds of brain-targeted liposomes co-modified by RVGP and R9 in different ways	6
Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal	6
Plant-derived extracellular vesicles as a natural drug delivery platform for glioblastoma therapy: A dual role in preserving endothelial integrity while modulating the tumor microenvironment	5
Research progress of penetration enhancers in transdermal drug delivery systems: Multidimensional exploration from mechanisms to clinical application	5
Targeted probiotic tabletting: A hybrid active learning and finite element modelling approach for process optimisation	5
RETRACTED: Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-v	5
Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications	5
Optimizing microRNA delivery via albumin-decorated nanostructured lipid carriers	5
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications	5
Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment	5
Extraction of the polysorbate 20 and 80 fingerprint via generative modeling	5
The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little	5
Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy	5
Development of a potential nano-based delivery system combining Colchicine-loaded lipid nanocapsules and BIOT-NFL-peptide to target glioblastoma	5
Nebulized macrophage membrane-engineered triptolide liposomes for Siglec-10/CD24-mediated therapeutic targeting in lung cancer	5
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimizat	5

Revolutionary hyaluronic acid-modified edge-activated spanlastics as a novel approach to boost Hepatoprotective activity of Curcumin: Optimization, biochemical analysis and in-vivo assessment	5
RP-HPLC-CAD method for the rapid analysis of lipids used in lipid nanoparticles derived from dual centrifugation	4
Retraction notice to “Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutic	4
Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy	4
The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation proce	4
The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing	4
Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through in vivo expression	4
Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions	4
How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up	4
Advanced microfluidic techniques for the preparation of solid lipid nanoparticles: Innovations and biomedical applications	4
Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation	4
Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells	4
Biomimetic nanotherapy for P. gingivalis-infected oral squamous cell carcinoma: Photothermal therapy and immunoactivation via precise intracellular bacterial elimination	4
WITHDRAWN: The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating	4
Co-assembled Glycyrrhiza nanoparticles embedded supramolecular protein hydrogels to enhance licochalcone A release for acute inflammation management	4
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation	4
Oxidation of polysorbates – An underestimated degradation pathway?	4
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending	4
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin	4
Release mechanisms of PLGA-based drug delivery systems: A review	4
Liposomal glytrexate formulation: improving antitumour efficacy and minimizing toxicity in breast cancer therapy	4
pH-responsive polymeric nanoparticles for peptide delivery: Synergistic STING pathway activation enhances tumor immunotherapy	4