OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Pharmaceutics-X is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice	116
Tailored ASD destabilization - Balancing shelf life stability and dissolution performance with hydroxypropyl cellulose	42
Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics	34
Tailored transethosomal systems for tadalafil transdermal delivery: Impact of Phosal and edge activators on skin permeation and cellular uptake	34
Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges	32
Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals	28
HSPiP and QbD oriented optimized nanocubosomes for ameliorated absorption of tolterodine tartrate: In vitro and in vivo evaluations	26
Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications	24
Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons	22
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation	19
Enhancing oocyte in vitro maturation and quality by melatonin/bilirubin cationic nanoparticles: A promising strategy for assisted reproduction techniques	18
Modeling of physical-mechanical and microbiological properties of tablets made of complex fluidized bed granules containing living yeast cells using common mixing rules	18
Exploring bioadhesion: insight on innovative strategies to investigate bioadhesive scaffolds	17
Erratum regarding missing Conflict of Interest statements in previously published articles	17
Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors	17
Synergistic photodynamic and chemodynamic therapy using hypoxia-adaptive Ce6@Co nanoparticles for enhanced tumor suppression	17
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin	17
Construction and applications of exosome-microneedle integrated systems	16
Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process	16
Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion	15
MgZnFe-layered double hydroxides as a dual-function platform for enhancing subunit vaccine efficacy in tumor immunotherapy	15
A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying	14
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets	14
A blood-brain barrier-penetrating nanoreactor for tumor microenvironment modulation, precise MR imaging and synergistic therapy of glioma	14
Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery	13

RETRACTED: Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutics:X Volume	13
Editorial Board	13
Polycaprolactone – Vitamin E TPGS micelles for delivery of paclitaxel: In vitro and in vivo evaluation	13
A novel EGFR-targeted photosensitizer for the theranostics of skin cancer	12
Preparation and in vitro property evaluation of NO-HA@ICG self-assembled nanoparticles for gas therapy synergized with phototherapy	12
Predicting pharmaceutical inkjet printing outcomes using machine learning	11
Glucose-functionalized redox-responsive dihydroartemisinin prodrug nanosystem for targeted malaria therapy	11
Comparative evaluation of ternary amorphous solid dispersions: Identifying optimal excipient systems for enhancing drug solubility	11
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia	11
Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat	11
Corrigendum to “Quantitative comparison of the protein corona of nanoparticles with different matrices” [Int J Pharm X 2022 Oct 21;4: 100136]	11
Iontophoretic delivery of caspofungin acetate to the cornea and sclera and its intracorneal biodistribution	11
A network of regulatory innovations to improve FDA quality assessments of human drug applications	10
Preservative-free electrospun nanofibrous inserts for sustained delivery of ceftazidime; design, characterization and pharmacokinetic investigation in rabbit's eye	10
A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process	10
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell li	10
Life cycle assessment of pharmaceutical tablet manufacturing: A comparative analysis and systems model integration framework	10
Formulation, in silico, in vitro characterization, cytotoxicity and cellular uptake of cyclodextrin complexes and ion pairing/salt formation with functional excipients (azelaic acid, tartaric acid, an	10
Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cel	10
Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide	10
Comparative study on two kinds of brain-targeted liposomes co-modified by RVGP and R9 in different ways	9
A model-based optimization strategy to achieve fast and robust freeze-drying cycles	9
Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies	9
Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning	9
Does the appearance of the Magenstrasse depend on the amount of water consumed?	9
Fucoidan/Polyvinylpyrrolidone/Hesperitin nanoparticle complex for corneal injury treatment: Synthesis, characterization, and therapeutic efficacy	9
Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis	9
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions	8
Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal	8
CD276-directed supramolecular nanoplatform with pH-triggered gemcitabine release for potent tumor stromal and vascular suppression	8
HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations	8
Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and tr	8
Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation	8
Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma	8
Editorial board	8
The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little	7
Ionic liquids self-assembled micelles for transdermal delivery: characterization, functions and applications	7
Revolutionary hyaluronic acid-modified edge-activated spanlastics as a novel approach to boost Hepatoprotective activity of Curcumin: Optimization, biochemical analysis and in-vivo assessment	7
Development of a potential nano-based delivery system combining Colchicine-loaded lipid nanocapsules and BIOT-NFL-peptide to target glioblastoma	7
Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy	7
Plant-derived extracellular vesicles as a natural drug delivery platform for glioblastoma therapy: A dual role in preserving endothelial integrity while modulating the tumor microenvironment	7
RETRACTED: Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-v	7
Optimizing microRNA delivery via albumin-decorated nanostructured lipid carriers	7
Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability	7
Nebulized macrophage membrane-engineered triptolide liposomes for Siglec-10/CD24-mediated therapeutic targeting in lung cancer	7
Targeted probiotic tabletting: A hybrid active learning and finite element modelling approach for process optimisation	6
Research progress of penetration enhancers in transdermal drug delivery systems: Multidimensional exploration from mechanisms to clinical application	6
How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up	6
Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy	6
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation	6

Extraction of the polysorbate 20 and 80 fingerprint via generative modeling	6
RP-HPLC-CAD method for the rapid analysis of lipids used in lipid nanoparticles derived from dual centrifugation	6
Oxidation of polysorbates – An underestimated degradation pathway?	6
Advanced microfluidic techniques for the preparation of solid lipid nanoparticles: Innovations and biomedical applications	6
Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment	6
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications	6
Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation	6
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimizat	6
Retraction notice to “Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutic	6
Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells	5
Release mechanisms of PLGA microparticles prepared using a microfluidics device or a beaker	5
Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through in vivo expression	5
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin	5
Release mechanisms of PLGA-based drug delivery systems: A review	5
Modelling intramuscular drug fate in vitro with tissue-relevant biomimetic hydrogels	5
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending	5
Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions	5
Hypoxia-responsive Exatecan prodrug liposomes co-delivered with IR808 for synergistic chemo–photodynamic therapy of breast cancer	5
Biomimetic nanotherapy for P. gingivalis-infected oral squamous cell carcinoma: Photothermal therapy and immunoactivation via precise intracellular bacterial elimination	5
The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation proce	5
pH-responsive polymeric nanoparticles for peptide delivery: Synergistic STING pathway activation enhances tumor immunotherapy	5
Co-assembled Glycyrrhiza nanoparticles embedded supramolecular protein hydrogels to enhance licochalcone A release for acute inflammation management	5
A single oral administration of resveratrol cocrystals enables potent antisepsis therapy via interfering neutrophil extracellular traps formation	5
The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing	5
Liposomal glytrexate formulation: improving antitumour efficacy and minimizing toxicity in breast cancer therapy	5