iScience

Article	Citations
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	463
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	258
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	256
Design and validation of depth camera-based static posture assessment system	234
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	225
Risk of cerebrovascular disease after cancer diagnosis in the United States	202
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	156
Decline in stability of forest productivity in the tropics as determined by canopy water content	144
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	133
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	130
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	127
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	125
Dose-dependent association between physical activity and mental health, and mitigation effects on risk behaviors	124
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	122
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	111
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	110
Visual deprivation induces a stronger dive response in a harbor porpoise	110
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	107
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	104
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	104
Sound effects on body perception vary with the social support network of individuals	103
Iterative multiscale and multi-physics computations for operando catalyst nanostructure elucidation and kinetic modeling	102
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	102
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	99
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	96

Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	95
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	95
Some dogs can find the payoff-dominant outcome in the Assurance game	95
Thermal conductivity across transition metal dichalcogenide bilayers	94
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	93
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	91
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	91
How do preschoolers and adults ascribe authority?	90
The trogocytosis of neutrophils on initial transplanted tumor in mice	88
Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade	88
Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers	88
Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC	88
Social rank-dependent effects of testosterone on huddling strategies in mice	85
Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis	83
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	82
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	82
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	81
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	80
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	80
T cells with increased responsiveness cause obesity in mice without diet intervention	79
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	79
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	78
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2	78
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	78
Oleuropein activates autophagy to circumvent anti-plasmodial defense	77
The roles of lncMALAT1 in coronary artery disease regulation and therapeutic perspective: A systematic review	77
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	77
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	77
Enhancing mRNA translation efficiency with discriminative and generative artificial intelligence by optimizing 5′ UTR sequences	76
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo	76
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	75
An NLP-based technique to extract meaningful features from drug SMILES	75
Release of extracellular DNA by Pseudomonas sp. as a major determinant for biofilm switching and an early indicator for cell population control	73
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	73
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	73
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	72
Traffic noise inhibits inhibitory control in wild-caught songbirds	71
Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest	70
Machine learning unveils immune-related signature in multicenter glioma studies	70
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	70
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	69
The role of chirality and plastic crystallinity in the optical and mechanical properties of chlorosomes	69
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	69
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	68
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	68
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	68
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	67
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	67
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	67
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	67

A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	67
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus	66
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	66
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	66
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	66
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	66
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes	66
TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination	66
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	66
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	65
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids	65
Audition controls the flow of visual time during multisensory perception	64
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	63
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	63
Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion	63
A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	61
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	61
Lifespan associations of resting-state brain functional networks with ADHD symptoms	61
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina	61
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	61
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	61
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	61
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	61
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	60
Short-term auditory priming in freely-moving mice	60
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19	60
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	59
Prefrontal cortex encodes value pop-out in visual search	59
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	59
Genome editing is induced in a binary manner in single human cells	58
Predictable sequential structure augments auditory sensitivity at threshold	58
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	58
Sample multiplexing for retinal single-cell RNA sequencing	58
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	58
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	58
Multi-omic profiling of pathogen-stimulated primary immune cells	58
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	57
DLL3 regulates Notch signaling in small cell lung cancer	57
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	57
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	57
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	57
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	57
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	56
Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults	56
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	55
Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells	55
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus	55
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue	54
Sverdrup-Henson crater: A candidate location for the first lunar South Pole settlement	54
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	54
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	54
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	54
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system	53
Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	52
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	52
Impact of ATF6 deletion on the embryonic brain development	52
Nanozyme-based wearable biosensors for application in healthcare	52
Broadband circularly polarized magneto-electric dipole antenna for millimeter-wave communication	51
Inspired by struggle: A personal journey to global precision brain health	51
Integrated edge information and pathway topology for drug-disease associations	51
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	50
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	50
An SI-traceable reference material for virus-like particles	50
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	49
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	49
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection	49
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	49
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective	49
Standardized two-step testing of antibody activity in COVID-19 convalescent plasma	49
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	49
Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p	48
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	48
Detecting tandem repeat variants in coding regions using code-adVNTR	48
Exploring drought-responsive crucial genes in Sorghum	48
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	48
Matter-wave gap solitons and vortices in three-dimensional parity-time-symmetric optical lattices	48
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	48
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	48
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence	47
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	47

Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	47
Trash-to-fuel: Converting municipal waste into transportation fuels by pyrolysis	47
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	47
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	46
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	46
Ecological firewalls for synthetic biology	46
Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces	46
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	46
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	46
Oxytocin promotes social proximity and decreases vigilance in groups of African lions	46
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	46
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	46
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand	46
Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles	46
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	46
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	46
Multilingual multi-aspect explainability analyses on machine reading comprehension models	46
Exploring the roles of intestinal flora in enhanced recovery after surgery	46
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	45
Eco-evolutionary feedbacks under artificial light at night	45
Targeting Claudin18.2 for cancer theranostics: From molecular imaging to precision therapy	45
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	45
Chronic disease incidence explained by stepwise models and co-occurrence among them	45
Extracellular vesicles: Antiviral functions and applications in therapeutics and vaccines	45
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	45
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	45
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	45
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	44
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia	44
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	44
Developmental analysis of visually-evoked defensive behaviors identifies age and sex-specific responses and underlying synaptic and glial changes	44
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	44
Tickle contagion in the rat somatosensory cortex	44
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	44
Insights into the hydrogen generation and catalytic mechanism on Co-based nanocomposites derived from pyrolysis of organic metal precursor	44
Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid	44
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	44
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	44
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma	44
Multifunctional injectable GelMA hydrogel incorporating Icariin loaded Mesoporous silica nanoparticles to promote osseointegration	44
Investigating the impacts of future oil prices on the achievement of 1.5°C climate goal	44
The cutaneous response to a mosquito bite is influenced by the diurnal rhythm	43
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses	43
Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families	43
Does shoe cushioning space affect patellofemoral pain risk? A study based on the integrated finite element model	43
Unrevealed effect of silver species on hydrocarbon pool in ethylene conversion on ZSM-5 by 2D COS FT-IR and 2D COS UV-vis operando spectroscopies	43
Condensation of water vapor from humid air inside vertical channels formed by flat plates	43
Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	43
MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning	42
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	42
Temporal dynamics of the soil bacterial community following Bacillus invasion	42
Type I interferon regulation by USP18 is a key vulnerability in cancer	42
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	42
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	42
Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis	42
Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer	42
Immune microenvironment and fibroblast subpopulation in diabetic wound healing	42
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	42
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	42
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	42
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models	42
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	42
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	42
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	42
Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling	41
Applications of single-cell technologies in drug discovery for tumor treatment	41
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	41
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	41
Do not compromise: Nurse honeybees practice strict protein-lipid regulation	41
A limitation map of performance for porous electrodes in lithium-ion batteries	41
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	41
Global burden of head and neck cancers from 1990 to 2019	41
Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens	41
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	41
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	41
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life	40
Hydroxyapatite catalyzed hydrothermal liquefaction transforms food waste from an environmental liability to renewable fuel	40
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses	40
An AI-driven workflow for the accelerated optimization of cell-free protein synthesis	40
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	40
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	40
Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer	40
Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models	40
Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor	40
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides	40
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	40
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	40
Data-driven models and digital twins for sustainable combustion technologies	40
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	40
Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics	40
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome	40
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response	40
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	40
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	40
Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?	40