iScience

Article	Citations
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	365
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	339
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	335
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	205
A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies	172
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	165
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	151
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	138
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	129
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	118
Chronic disease incidence explained by stepwise models and co-occurrence among them	118
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	111
Visual deprivation induces a stronger dive response in a harbor porpoise	110
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	110
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	110
Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	107
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	106
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	106
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	105
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	105
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	103
Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid	102
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	102
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses	101
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	98

Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	97
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	95
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	94
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	93
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response	93
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	93
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	91
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	91
Exploring drought-responsive crucial genes in Sorghum	91
Integrated edge information and pathway topology for drug-disease associations	90
Spatiotemporal patterns and drivers of ecosystem service interactions in karst regions: Insights for environmental protection and sustainability	88
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	88
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	88
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses	88
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	88
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	87
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	87
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	86
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	85
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	84
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	84
Tickle contagion in the rat somatosensory cortex	82
Impact of ATF6 deletion on the embryonic brain development	81
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	80
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	79
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	78
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	78
Design and validation of depth camera-based static posture assessment system	78
How do preschoolers and adults ascribe authority?	77
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	77
Some dogs can find the payoff-dominant outcome in the Assurance game	76
Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade	76
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	76
Variational adaptive Gaussian approximation filter for nonlinear systems with generalized unknown disturbances	75
Systemic cyst(e)inase administration induces ferroptosis and synergizes with temozolomide in glioblastoma	75
Chidamide: Exploration of maintenance therapy for patients with DLBCL with HBV infection	74
Montmorillonite and amino acid composites for heavy metal ion adsorption	74
Social rank-dependent effects of testosterone on huddling strategies in mice	73
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	73
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	73
Audition controls the flow of visual time during multisensory perception	73
Machine learning unveils immune-related signature in multicenter glioma studies	72
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	72
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	71
Short-term auditory priming in freely-moving mice	71
An NLP-based technique to extract meaningful features from drug SMILES	71
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	71
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	70
Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells	70
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	69

The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	69
Preparation of WSi@SiOx/Ti3C2 from photovoltaic silicon waste as high-performance anode materials for lithium-ion batteries	69
Decline in stability of forest productivity in the tropics as determined by canopy water content	68
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	68
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	67
Risk of cerebrovascular disease after cancer diagnosis in the United States	66
Hydroxyapatite catalyzed hydrothermal liquefaction transforms food waste from an environmental liability to renewable fuel	66
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	65
Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors	65
MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning	65
Bta-miR-30f promotes adipogenesis and unsaturated fatty acid accumulation by targeting RAD23B in buffalo intramuscular preadipocytes	64
Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis	63
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	63
Biosynthesis of polyamine-polyphosphate granules for colitis alleviation	63
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection	62
Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces	62
Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest	62
An AI-driven workflow for the accelerated optimization of cell-free protein synthesis	62
Differentiation of mesenchymal stem/stromal cells into CD45+ macrophage-like cells: expanding insights into MSC plasticity	61
Lifespan associations of resting-state brain functional networks with ADHD symptoms	61
Origin of replication discovery for environmentally isolated Pantoea strain enables expression of heterologous proteins, pathways and products	61
Neural extracellular matrix regulates visual sensory motor integration	61
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	61
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand	61
MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway	61
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma	61
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	60
Sound effects on body perception vary with the social support network of individuals	60
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	59
Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation	59
RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics	58
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	58
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	58
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	57
Developmental analysis of visually evoked defensive behavior identifies age and sex-specific responses and underlying synaptic and glia changes	57
RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B	57
Does shoe cushioning space affect patellofemoral pain risk? A study based on the integrated finite element model	57
Red blood cell flickering activity locally controlled by holographic optical tweezers	57
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	57
Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models	57
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	56
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	56
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	56
Perovskite-based photodetector for real-time and quantitative monitoring of sports motion	55
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	55
Prefrontal cortex encodes value pop-out in visual search	55
Iterative multiscale and multi-physics computations for operando catalyst nanostructure elucidation and kinetic modeling	55
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	55
Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer	55
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	55
Large-scale and cost-efficient agrivoltaics system by spectral separation	54
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	54
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	54
Broadband circularly polarized magneto-electric dipole antenna for millimeter-wave communication	53
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	53
Targeting Claudin18.2 for cancer theranostics: From molecular imaging to precision therapy	53
Enhancing mRNA translation efficiency with discriminative and generative artificial intelligence by optimizing 5′ UTR sequences	53
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	53
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	52
Insights into the hydrogen generation and catalytic mechanism on Co-based nanocomposites derived from pyrolysis of organic metal precursor	52
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	52
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	52
Thermal conductivity across transition metal dichalcogenide bilayers	52
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	52
Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets	52
Sample multiplexing for retinal single-cell RNA sequencing	52
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	52
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	52
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	52
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	52
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	51
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	51
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	51
Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers	51
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	51
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	50
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	50
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	50
Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion	50
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids	50

Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	50
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	50
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	50
Multi-omic profiling of pathogen-stimulated primary immune cells	49
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	49
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma	49
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	49
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue	49
Projected cardiovascular mortality attributable to extreme temperatures under climate scenarios in Taiyuan, China	49
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	49
The trogocytosis of neutrophils on initial transplanted tumor in mice	49
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	49
Endovascular management for post-dissection aortic aneurysm after prior proximal repair	48
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	48
Epigenetic mechanisms and steroid-resistant nephrotic syndrome: The future potential for SRNS diagnosis	48
Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC	48
Modulation of attractive salt taste in Drosophila	48
Comparison of the performance of large language models in answering patient questions related to cataract	48
Fluoroscopic control of a magnetorobotic capsule for precision gastrointestinal sampling and delivery	48
pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy	47
Multifunctional injectable GelMA hydrogel incorporating Icariin-loaded Mesoporous silica nanoparticles to promote osseointegration	47
Global burden of head and neck cancers from 1990 to 2019	47
Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function	47
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease	47
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	47
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	47
DLL3 regulates Notch signaling in small cell lung cancer	47
Ecological firewalls for synthetic biology	47
Exploring the roles of intestinal flora in enhanced recovery after surgery	47
Reinforcement learning for dynamic speed control in connected and autonomous vehicles: A review of applications and challenges	47
Dynamic tracking of breastfeeding and weaning in carbon isotopes of tooth enamel	46
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen	46
Bisphenol A and breast cancer: Can mechanistic plausibility be reconciled with epidemiological inconsistency?	46
Unscrambling the history of African indicine cattle genomes	46
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	46
Kinetics of resilience with onset and remission of pediatric functional gastrointestinal disorders: A longitudinal study	46
A platelet-rich plasma-loaded chitosan-based hydrogel for promoting type 2 diabetes wound healing	46
Data-driven models and digital twins for sustainable combustion technologies	46
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina	45
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	45
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	45
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	45
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	45
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	45
Type I interferon regulation by USP18 is a key vulnerability in cancer	45
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	45
Genome editing is induced in a binary manner in single human cells	45
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	45
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	45
Do not compromise: Nurse honeybees practice strict protein-lipid regulation	45
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19	45
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	45
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	45
Sverdrup-Henson crater: A candidate location for the first lunar South Pole settlement	45
DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis	45
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	44
Temporal rich-club phenomenon and its formation mechanisms in international trade: Evidence from new energy minerals	44
Investigating the impacts of future oil prices on the achievement of 1.5°C climate goal	44
Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration	44
Oleuropein activates autophagy to circumvent anti-plasmodial defense	44
Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies	44
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	43
Suggested experimental design and computational modeling to infer single-cell lipid dynamics from a single destructive measurement	43
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	43
The cutaneous response to a mosquito bite is influenced by the diurnal rhythm	43
Augmentation of self-motion perception with synthetic auditory cues	43
Obesity mediates the association of outdoor artificial light at night with type 2 diabetes mellitus	43
Toward accurate prediction of pediatric epidemic disease patient volume in the Chaoshan region: A deep learning framework	43
T cells with increased responsiveness cause obesity in mice without diet intervention	42
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus	42
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	42
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	42
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	42
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	42
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	42
Evolutionarily entrenched odorant receptors for (E)-β-farnesene signaling in Aphidinae aphids	42
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	41
A model decomposition method for the real-time non-line-of-sight imaging	41
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models	41
Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice	41
Twitching in sleeping premature infants provides a sensitive behavioral assay of early motor control	41
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	41
Platform, modality, and gamification effects on digit span task performance	41
Integrating gene-microbiome interactions and single-cell transcriptomics reveals therapeutic strategies for aortic aneurysm	40
Understanding Plasmodium vivax recurrent infections using an amplicon deep sequencing assay, identity-by-descent and model-based classification	40
Leisure-time physical activity modulates associations of sarcopenia and functional disability with mortality in older adults	40
Microwave ablation synergizes with LPS to drive abscopal tumor regression associated with ferroptosis in HCC	40
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	39
Immune microenvironment and fibroblast subpopulation in diabetic wound healing	39
Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families	39
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	39
Halide doping and morphology engineering in bismuth-based MOFs for enhanced water oxygen evolution	39
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	39
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	39
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	39