iScience

Article	Citations
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	449
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	242
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	241
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	217
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	209
Design and validation of depth camera-based static posture assessment system	180
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	175
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	151
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	146
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	140
Risk of cerebrovascular disease after cancer diagnosis in the United States	128
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	125
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	124
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	119
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	119
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	119
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	110
Decline in stability of forest productivity in the tropics as determined by canopy water content	108
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	108
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	107
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	106
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	103
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	102
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	102
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	100

Some dogs can find the payoff-dominant outcome in the Assurance game	100
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	97
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	95
Thermal conductivity across transition metal dichalcogenide bilayers	94
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma	94
Genome editing is induced in a binary manner in single human cells	93
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	93
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	92
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	91
An NLP-based technique to extract meaningful features from drug SMILES	91
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	91
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	89
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	88
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	87
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life	87
Traffic noise inhibits inhibitory control in wild-caught songbirds	87
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	87
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	85
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	83
Short-term auditory priming in freely-moving mice	83
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	82
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	81
Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors	78
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	78
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	78
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	78
Impact of myocardial reperfusion on human plasma lipidome	76
Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis	75
Immune microenvironment and fibroblast subpopulation in diabetic wound healing	75
Social rank-dependent effects of testosterone on huddling strategies in mice	75
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	74
Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers	74
Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade	74
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids	74
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	74
Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces	73
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	73
How do preschoolers and adults ascribe authority?	72
The trogocytosis of neutrophils on initial transplanted tumor in mice	72
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	72
Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC	72
Insights into the hydrogen generation and catalytic mechanism on Co-based nanocomposites derived from pyrolysis of organic metal precursor	72
Multilingual multi-aspect explainability analyses on machine reading comprehension models	71
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	70
Bacterial lipopolysaccharides can initiate regeneration of the Xenopus tadpole tail	70
Applications of single-cell technologies in drug discovery for tumor treatment	69
Unrevealed effect of silver species on hydrocarbon pool in ethylene conversion on ZSM-5 by 2D COS FT-IR and 2D COS UV-vis operando spectroscopies	69
Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid	69
Does shoe cushioning space affect patellofemoral pain risk? A study based on the integrated finite element model	68
The cutaneous response to a mosquito bite is influenced by the diurnal rhythm	68

Investigating the impacts of future oil prices on the achievement of 1.5°C climate goal	68
A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies	67
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	67
RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics	67
Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets	67
Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor	67
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	66
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	66
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	65
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	65
How many markers are needed to robustly determine a cell's type?	65
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	65
Sverdrup-Henson crater: A candidate location for the first lunar South Pole settlement	64
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	64
A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	63
Audition controls the flow of visual time during multisensory perception	63
Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer	63
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	63
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	62
Type I interferon regulation by USP18 is a key vulnerability in cancer	62
T cells with increased responsiveness cause obesity in mice without diet intervention	61
DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis	61
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	60
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	60
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	60
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	60
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	60
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	60
Oxytocin promotes social proximity and decreases vigilance in groups of African lions	59
High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors	59
Red blood cell flickering activity locally controlled by holographic optical tweezers	59
Detecting tandem repeat variants in coding regions using code-adVNTR	58
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	57
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	57
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	57
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	57
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	56
Quantitative analysis of asynchronous transcription-translation and transcription processivity in Bacillus subtilis under various growth conditions	56
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	56
Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles	56
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2	55
Trash-to-fuel: Converting municipal waste into transportation fuels by pyrolysis	55
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	54
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	54
Oleuropein activates autophagy to circumvent anti-plasmodial defense	54
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	54
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	54
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue	53
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	53
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	53
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	53
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	53
The role of chirality and plastic crystallinity in the optical and mechanical properties of chlorosomes	53
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	53
Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells	53
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo	52
Extracellular vesicles: Antiviral functions and applications in therapeutics and vaccines	52
Matter-wave gap solitons and vortices in three-dimensional parity-time-symmetric optical lattices	51
Enhancing mRNA translation efficiency with discriminative and generative artificial intelligence by optimizing 5′ UTR sequences	51
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	51
Targeting Claudin18.2 for cancer theranostics: From molecular imaging to precision therapy	51
Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies	51
Broadband circularly polarized magneto-electric dipole antenna for millimeter-wave communication	51
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	50
An AI-driven workflow for the accelerated optimization of cell-free protein synthesis	50
Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	50
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	50
Multi-omic profiling of pathogen-stimulated primary immune cells	50
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	50
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	49
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	49
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	49
Chronic disease incidence explained by stepwise models and co-occurrence among them	48
Standardized two-step testing of antibody activity in COVID-19 convalescent plasma	48
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	48
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	48
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective	48
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	47
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	47
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19	47

Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	47
Inspired by struggle: A personal journey to global precision brain health	47
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	47
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	47
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	47
ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition	47
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	46
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	46
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	46
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	46
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	46
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	46
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome	46
Integrated edge information and pathway topology for drug-disease associations	46
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	46
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	46
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	46
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	46
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	45
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease	45
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	45
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system	45
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	45
Machine learning unveils immune-related signature in multicenter glioma studies	45
Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens	45
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	45
Dose-dependent association between physical activity and mental health, and mitigation effects on risk behaviors	45
Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion	45
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence	45
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	44
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	44
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	44
TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination	44
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	44
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection	44
Impact of ATF6 deletion on the embryonic brain development	44
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus	44
Release of extracellular DNA by Pseudomonas sp. as a major determinant for biofilm switching and an early indicator for cell population control	44
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses	44
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	44
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	44
Sample multiplexing for retinal single-cell RNA sequencing	44
Eco-evolutionary feedbacks under artificial light at night	43
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes	43
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	43
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	43
Hydroxyapatite catalyzed hydrothermal liquefaction transforms food waste from an environmental liability to renewable fuel	43
Predictable sequential structure augments auditory sensitivity at threshold	43
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	43
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	43
Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults	42
A limitation map of performance for porous electrodes in lithium-ion batteries	42
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	42
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	42
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	42
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	42
Nanozyme-based wearable biosensors for application in healthcare	42
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	42
Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis	42
Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p	42
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	42
Visual deprivation induces a stronger dive response in a harbor porpoise	42
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	41
Exploring the roles of intestinal flora in enhanced recovery after surgery	41
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	41
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	41
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	41
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	41
Large-scale and cost-efficient agrivoltaics system by spectral separation	40
Prefrontal cortex encodes value pop-out in visual search	40
Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling	40
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	40
Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis	40
Data-driven models and digital twins for sustainable combustion technologies	40
MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning	40
Temporal dynamics of the soil bacterial community following Bacillus invasion	40
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	40
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	40
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	40
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	40
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia	40
Ecological firewalls for synthetic biology	40
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	40
Exploring drought-responsive crucial genes in Sorghum	40
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models	40
Iterative multiscale and multi-physics computations for operando catalyst nanostructure elucidation and kinetic modeling	39
Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics	39
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand	39
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	39
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	39
An SI-traceable reference material for virus-like particles	39
Environmental and health risks of perovskite solar modules: Case for better test standards and risk mitigation solutions	39
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	39
Lifespan associations of resting-state brain functional networks with ADHD symptoms	39
Global burden of head and neck cancers from 1990 to 2019	39