iScience

Article	Citations
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	411
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	388
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	365
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	229
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	191
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	176
Chronic disease incidence explained by stepwise models and co-occurrence among them	169
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	146
Visual deprivation induces a stronger dive response in a harbor porpoise	138
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	137
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	130
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	127
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	126
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	124
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response	121
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	118
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	117
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	116
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	113
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	113
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	112
How do preschoolers and adults ascribe authority?	112
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	112
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	110
Some dogs can find the payoff-dominant outcome in the Assurance game	107

Variational adaptive Gaussian approximation filter for nonlinear systems with generalized unknown disturbances	106
Chidamide: Exploration of maintenance therapy for patients with DLBCL with HBV infection	103
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	103
Social rank-dependent effects of testosterone on huddling strategies in mice	102
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	101
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	100
Short-term auditory priming in freely-moving mice	100
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	100
Decline in stability of forest productivity in the tropics as determined by canopy water content	98
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	97
Risk of cerebrovascular disease after cancer diagnosis in the United States	96
Hydroxyapatite catalyzed hydrothermal liquefaction transforms food waste from an environmental liability to renewable fuel	96
An AI-driven workflow for the accelerated optimization of cell-free protein synthesis	95
Sound effects on body perception vary with the social support network of individuals	94
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	93
Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation	93
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	92
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	92
Prefrontal cortex encodes value pop-out in visual search	90
Perovskite-based photodetector for real-time and quantitative monitoring of sports motion	88
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	88
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	87
Targeting Claudin18.2 for cancer theranostics: From molecular imaging to precision therapy	85
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	84
Broadband circularly polarized magneto-electric dipole antenna for millimeter-wave communication	84
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	83
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	83
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	82
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	82
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	82
Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	81
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	81
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	80
Multi-omic profiling of pathogen-stimulated primary immune cells	80
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids	80
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	80
Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function	79
pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy	79
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	79
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	79
Exploring the roles of intestinal flora in enhanced recovery after surgery	79
Dynamic tracking of breastfeeding and weaning in carbon isotopes of tooth enamel	79
Kinetics of resilience with onset and remission of pediatric functional gastrointestinal disorders: A longitudinal study	78
A platelet-rich plasma-loaded chitosan-based hydrogel for promoting type 2 diabetes wound healing	78
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina	76
Bisphenol A and breast cancer: Can mechanistic plausibility be reconciled with epidemiological inconsistency?	76
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	76
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	74
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	73
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	73

Genome editing is induced in a binary manner in single human cells	73
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	72
Toward accurate prediction of pediatric epidemic disease patient volume in the Chaoshan region: A deep learning framework	72
Suggested experimental design and computational modeling to infer single-cell lipid dynamics from a single destructive measurement	72
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	70
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	70
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	70
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	70
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	69
The rise of chiral carbon nanomaterials: From chirality-governed mechanisms to future environmental applications	68
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	68
ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition	68
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	68
Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	66
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	66
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	66
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	66
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo	65
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma	65
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	64
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	64
Inspired by struggle: A personal journey to global precision brain health	64
Montmorillonite and amino acid composites for heavy metal ion adsorption	64
Sverdrup-Henson crater: A candidate location for the first lunar South Pole settlement	63
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	62
The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem	62
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	62
Detecting tandem repeat variants in coding regions using code-adVNTR	62
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	61
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	61
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	61
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	60
Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens	60
Applications of single-cell technologies in drug discovery for tumor treatment	59
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	59
Exploring drought-responsive crucial genes in Sorghum	59
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	59
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	59
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	59
Preparation of WSi@SiOx/Ti3C2 from photovoltaic silicon waste as high-performance anode materials for lithium-ion batteries	58
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	57
Traffic noise inhibits inhibitory control in wild-caught songbirds	57
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	57
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	57
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand	57
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	57
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	57
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	57
Dose-dependent association between physical activity and mental health, and mitigation effects on risk behaviors	57
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	57
Iterative multiscale and multi-physics computations for operando catalyst nanostructure elucidation and kinetic modeling	56
Does shoe cushioning space affect patellofemoral pain risk? A study based on the integrated finite element model	56
The cutaneous response to a mosquito bite is influenced by the diurnal rhythm	56
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses	56
Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families	56
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	55
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	55
Unrevealed effect of silver species on hydrocarbon pool in ethylene conversion on ZSM-5 by 2D COS FT-IR and 2D COS UV-vis operando spectroscopies	55
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	55
Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid	55
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	55
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	55
Investigating the impacts of future oil prices on the achievement of 1.5°C climate goal	55
Immune microenvironment and fibroblast subpopulation in diabetic wound healing	54
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	54
Understanding Plasmodium vivax recurrent infections using an amplicon deep sequencing assay, identity-by-descent and model-based classification	54
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides	53
DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis	53
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	53
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	53
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	53
Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest	53
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	53
Red blood cell flickering activity locally controlled by holographic optical tweezers	52
Predictable sequential structure augments auditory sensitivity at threshold	52
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	52
Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade	52
RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B	52
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	52
Microwave ablation synergizes with LPS to drive abscopal tumor regression associated with ferroptosis in HCC	51

Enterohemorrhagic Escherichia coli senses colonic oxygen availability to modulate its virulence and colonization	51
Neural decision dynamics underlying reinforcement learning and working memory	51
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	51
Composite disturbance observer-based sliding mode control strategies for unmanned surface vehicles with unmatched disturbances	50
Leisure-time physical activity modulates associations of sarcopenia and functional disability with mortality in older adults	50
Design and validation of depth camera-based static posture assessment system	50
Advances and challenges of hydrogel electrolytes for rechargeable zinc-iodine batteries	50
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2	50
Eco-evolutionary feedbacks under artificial light at night	50
Neuromuscular junction innervation and motor function are preserved by restoring muscarinic signaling in perisynaptic glia in ALS	50
Mediating mechanisms and urban diversity: How environmental risk perception shapes recycling behavior in China’s megacities	50
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	50
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	49
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	49
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	49
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	49
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	49
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus	49
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus	49
The trogocytosis of neutrophils on initial transplanted tumor in mice	48
Developmental analysis of visually evoked defensive behavior identifies age and sex-specific responses and underlying synaptic and glia changes	48
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	48
Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics	48
Insights into the hydrogen generation and catalytic mechanism on Co-based nanocomposites derived from pyrolysis of organic metal precursor	48
Unscrambling the history of African indicine cattle genomes	48
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	48
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses	48
A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	47
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	47
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	47
Global burden of head and neck cancers from 1990 to 2019	47
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	47
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	47
Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis	47
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma	47
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	47
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	46
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	46
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	46
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	46
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	46
Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors	46
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	45
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	45
Machine learning unveils immune-related signature in multicenter glioma studies	44
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	44
Data-driven models and digital twins for sustainable combustion technologies	44
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	44
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	44
Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces	43
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	43
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	43
The roles of lncMALAT1 in coronary artery disease regulation and therapeutic perspective: A systematic review	43
T cells with increased responsiveness cause obesity in mice without diet intervention	43
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	43
Sample multiplexing for retinal single-cell RNA sequencing	43
Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor	43
MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway	42
Comparison of the performance of large language models in answering patient questions related to cataract	42
Differentiation of mesenchymal stem/stromal cells into CD45+ macrophage-like cells: expanding insights into MSC plasticity	42
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	42
Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC	42
Integrated edge information and pathway topology for drug-disease associations	42
Modulation of attractive salt taste in Drosophila	42
Temporal rich-club phenomenon and its formation mechanisms in international trade: Evidence from new energy minerals	42
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	42
Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers	42
Evolutionarily entrenched odorant receptors for (E)-β-farnesene signaling in Aphidinae aphids	42
Origin of replication discovery for environmentally isolated Pantoea strain enables expression of heterologous proteins, pathways and products	42
Obesity mediates the association of outdoor artificial light at night with type 2 diabetes mellitus	42
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	42
Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies	42
Fluoroscopic control of a magnetorobotic capsule for precision gastrointestinal sampling and delivery	41
Endovascular management for post-dissection aortic aneurysm after prior proximal repair	41
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	41
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	41
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	41
Augmentation of self-motion perception with synthetic auditory cues	41
Projected cardiovascular mortality attributable to extreme temperatures under climate scenarios in Taiyuan, China	41
Neural extracellular matrix regulates visual sensory motor integration	41
DLL3 regulates Notch signaling in small cell lung cancer	41
Do not compromise: Nurse honeybees practice strict protein-lipid regulation	41
Epigenetic mechanisms and steroid-resistant nephrotic syndrome: The future potential for SRNS diagnosis	41
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	41
TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination	41
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	41
MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning	41
EID1 overexpression in brown adipose tissue enhances cold-induced thermogenesis in male mice	40
Retraction notice to “Understanding microbiota-driven oncogenesis: The role of metabolites in tumorigenesis” [iScience 28 (2025) 113945]	40
PM2.5 induced neurotoxicity and depression unveiling exposure risks and mechanistic insights	40
Large-scale and cost-efficient agrivoltaics system by spectral separation	40
Photovoltaic arrays reshape multitrophic biodiversity through spatial heterogeneity in Qinghai Tibet Plateau alpine meadows	40
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	40
Neurobiological and behavioral relevance of intrinsic functional connectome constraints on task-evoked neural activation	40
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	40