iScience

Article	Citations
Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits	355
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	195
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	188
Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest	177
Lifespan associations of resting-state brain functional networks with ADHD symptoms	175
Hydroxyapatite catalyzed hydrothermal liquefaction transforms food waste from an environmental liability to renewable fuel	170
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome	156
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	152
Standardized two-step testing of antibody activity in COVID-19 convalescent plasma	139
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	137
MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning	135
Bacterial surface properties influence the activity of the TAT-RasGAP317-326 antimicrobial peptide	128
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	121
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	115
Tendon-inspired anti-freezing tough gels	112
Targeting ITK signaling for T cell-mediated diseases	105
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	104
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	99
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	99
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	98
Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis	98
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	96
Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer	96
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	96
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	95

Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	94
Applications of single-cell technologies in drug discovery for tumor treatment	94
Type I interferon regulation by USP18 is a key vulnerability in cancer	94
Mass burial genomics reveals outbreak of enteric paratyphoid fever in the Late Medieval trade city Lübeck	93
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	91
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	89
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	85
Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets	85
Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults	84
Controllable preparation and performance of bio-based poly(lactic acid-iminodiacetic acid) as sustained-release Pb2+ chelating agent	83
The role of chirality and plastic crystallinity in the optical and mechanical properties of chlorosomes	82
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	81
Integrated edge information and pathway topology for drug-disease associations	80
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	80
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	80
T cells with increased responsiveness cause obesity in mice without diet intervention	79
Matter-wave gap solitons and vortices in three-dimensional parity-time-symmetric optical lattices	79
Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities	79
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	79
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	78
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	78
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	76
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	76
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	75
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	75
Thermal conductivity across transition metal dichalcogenide bilayers	75
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	75
Risk of cerebrovascular disease after cancer diagnosis in the United States	74
Visual deprivation induces a stronger dive response in a harbor porpoise	72
Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies	72
Some dogs can find the payoff-dominant outcome in the Assurance game	71
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	71
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	70
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	70
Exploring drought-responsive crucial genes in Sorghum	69
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	69
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	69
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	69
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models	69
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	68
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective	68
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	68
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	68
Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor	68
Social rank-dependent effects of testosterone on huddling strategies in mice	67
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	67
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	67
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	66
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	66
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	66

A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	65
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	65
Ecological firewalls for synthetic biology	64
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	64
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	64
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	63
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	63
Oxytocin promotes social proximity and decreases vigilance in groups of African lions	63
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	62
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	62
Genome editing is induced in a binary manner in single human cells	62
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	61
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	60
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	60
Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation	60
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	59
Sample multiplexing for retinal single-cell RNA sequencing	59
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	59
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	59
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis	58
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	58
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	58
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	58
Coexistence of large mammals and humans is possible in Europe's anthropogenic landscapes	57
Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p	57
Detecting tandem repeat variants in coding regions using code-adVNTR	57
Impact of myocardial reperfusion on human plasma lipidome	57
Tickle contagion in the rat somatosensory cortex	57
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	57
Traffic noise inhibits inhibitory control in wild-caught songbirds	56
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	56
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	56
Bidirectional electroactive microbial biofilms and the role of biogenic sulfur in charge storage and release	55
A resource of high-quality and versatile nanobodies for drug delivery	55
Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing	54
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	54
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	54
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	54
Pressure dependent thermoreflectance spectroscopy induced by interband transitions in metallic nano-film	53
Decline in stability of forest productivity in the tropics as determined by canopy water content	53
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	53
Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	53
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	53
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	53
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	53
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	53
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	52
A limitation map of performance for porous electrodes in lithium-ion batteries	52
Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS	52
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	52
Oleuropein activates autophagy to circumvent anti-plasmodial defense	52
Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?	52
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	52
An SI-traceable reference material for virus-like particles	51
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease	51
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	51
Audition controls the flow of visual time during multisensory perception	51
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	51
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	51
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	50
Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain	50
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	50
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	50
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	50
How many markers are needed to robustly determine a cell's type?	50
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease	50
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	50
Trash-to-fuel: Converting municipal waste into transportation fuels by pyrolysis	49
Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer	49
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	49
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	49
Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling	49
Nanozyme-based wearable biosensors for application in healthcare	49
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	48
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	48
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	48
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	48
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	48
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	47
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia	47

Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	47
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	47
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	47
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	47
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	47
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	47
Red blood cell flickering activity locally controlled by holographic optical tweezers	47
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	46
Predictable sequential structure augments auditory sensitivity at threshold	46
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	46
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	46
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	46
Chronic disease incidence explained by stepwise models and co-occurrence among them	46
Dose-dependent association between physical activity and mental health, and mitigation effects on risk behaviors	46
Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens	45
ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition	45
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes	45
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	45
Release of extracellular DNA by Pseudomonas sp. as a major determinant for biofilm switching and an early indicator for cell population control	45
Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis	45
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	45
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	45
Inspired by struggle: A personal journey to global precision brain health	44
TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination	44
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand	44
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	44
Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis	44
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	44
Bacterial lipopolysaccharides can initiate regeneration of the Xenopus tadpole tail	43
The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem	43
Perovskite-based photodetector for real-time and quantitative monitoring of sports motion	43
Fostering reproducibility, reusability, and technology transfer in health informatics	43
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	43
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	43
The trogocytosis of neutrophils on initial transplanted tumor in mice	43
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	43
Environmental and health risks of perovskite solar modules: Case for better test standards and risk mitigation solutions	43
Condensation of water vapor from humid air inside vertical channels formed by flat plates	43
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus	43
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	43
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	43
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	42
Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors	42
Multilingual multi-aspect explainability analyses on machine reading comprehension models	42
RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B	42
Short-term auditory priming in freely-moving mice	42
DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis	42
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	42
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	42
RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics	42
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	41
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	41
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	41
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system	41
Design and validation of depth camera-based static posture assessment system	41
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	41
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	41
Sverdrup-Henson crater: A candidate location for the first lunar South Pole settlement	41
Machine learning unveils immune-related signature in multicenter glioma studies	40
A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies	40
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	40
A host lipase prevents lipopolysaccharide-induced foam cell formation	40
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life	40
Prefrontal cortex encodes value pop-out in visual search	40
Data-driven models and digital twins for sustainable combustion technologies	40
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	40
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease	40
DLL3 regulates Notch signaling in small cell lung cancer	40
Multi-omic profiling of pathogen-stimulated primary immune cells	40
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	40
ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes	40
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	39
Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles	39
Preparation of WSi@SiOx/Ti3C2 from photovoltaic silicon waste as high-performance anode materials for lithium-ion batteries	39
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	39
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	39
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	39
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma	39
Exploring the roles of intestinal flora in enhanced recovery after surgery	39
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	39
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	39
High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors	39
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	39
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue	39
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function	39
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	39
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	38
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	38
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	38
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus	38
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	38
Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway	38
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	38
Temporal dynamics of the soil bacterial community following Bacillus invasion	38
Coking-resistant dry reforming of methane over Ni/γ-Al2O3 catalysts by rationally steering metal-support interaction	38