Life Science Alliance

Article	Citations
Gene-regulation modules in nonalcoholic fatty liver disease revealed by single-nucleus ATAC-seq	86
An immune-based tool platform for in vivo cell clearance	57
FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis	51
The ERK activator, BCI, inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement	48
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity	46
Metabolic adaptation pilots the differentiation of human hematopoietic cells	42
The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization	39
Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish	39
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway	39
GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells	39
Whole genome sequencing of drug resistanceMycobacterium tuberculosisfrom extra-pulmonary sites	37
An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65	36
Correction: Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome	36
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro	35
Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescence	34
B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses	33
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau	32
Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets	32
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms	31
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP	30
Mitochondrial phosphoproteomes are functionally specialized across tissues	30
The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development	30
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease	30
Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress	30
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations	29

Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models	29
Locally synthesized glycyl aminoacyl-tRNA synthetase is important for local translation in neurons	29
Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression	28
Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cells	28
Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification	28
Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect	28
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection	28
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing	28
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine	27
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis	26
A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2	26
Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	26
DA-Raf synergistically binds to the plasma membrane and Ras to suppress ERK signaling	25
Full-length MSP1 is a major target of protective immunity after controlled human malaria infection	25
Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis	25
The memory of airway epithelium damage in smokers and COPD patients	24
BATF3 regulates differentiation of CD8 + T lymphocytes and memory differentiation program	24
Unique activities of two overlappingPAX6retinal enhancers	23
Inflammasome is a central player in B cell development and homing	23
Loss of Y chromosome in Alzheimer’s patients co-occurs with somatic mutations beyond CHIP drivers	23
The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delays	23
A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+leak but activates SERCA2a Ca2+uptake	23
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma	23
SLAMF6 compartmentalization enhances T cell functions	23
Correction: Apolipoprotein E intersects with amyloid-β within neurons	23
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies	23
Peripheral immune system modulates Purkinje cell degeneration in Niemann–Pick disease type C1	23
The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors	23
Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes	23
RhoGEF Ect2 supports RhoA activity at cell–cell junctions through desmoplakin	22
Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer	22
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest	22
The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation	21
Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter	21
SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment	21
ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis	21
Conserved 3D genome reorganization during DNA repair	21
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures	21
Single variant, yet “double trouble”: TSC and KBG syndrome because of a large de novo inversion	21
Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5	21
The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis	20
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors	20
Lineage tracing reveals fate bias and transcriptional memory in human B cells	20
Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activation	20
Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ doses	20
BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes identified through gene network analysis	20
Horizontal transfer of therfbcluster inLeptospirais a genetic determinant of serovar identity	19
Interconnections between m6A RNA modification, RNA structure, and protein–RNA complex assembly	19
Identification of a novel enhancer essential for Satb1 expression in T H 2 cells and activated ILC2s	19
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope	19

The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface	19
A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells	19
Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice	19
DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications	19
Structural basis of translation inhibition by a valine tRNA-derived fragment	19
RAS and PP2A activities converge on epigenetic gene regulation	19
Müller cell glutamine metabolism links photoreceptor and endothelial injury in diabetic retinopathy	18
Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva	18
FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion	18
RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping	18
Off-targets of BRAF inhibitors disrupt endothelial signaling and vascular barrier function	18
Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells	18
KANSL3 directs transcriptional programs essential for hepatic metabolism and differentiation	18
POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels	18
Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages	18
Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores inSaccharomyces cerevisiae	18
Catalytic activity of KMT5B promotes ciliogenesis without affecting global chromatin accessibility	18
Renal antiporter ClC-5 regulates collagen I/IV through the β-catenin pathway and lysosomal degradation	18
Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands	18
PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs	18
Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A	18
EZH2 controls epicardial cell migration during heart development	18
Chromosome-specific barcode system with centromeric repeat in cultivated soybean and wild progenitor	17
Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma	17
Epigenetic signals that direct cell type–specific interferon beta response in mouse cells	17
Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBD	17
ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma	17
VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis	17
The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis	17
Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins	17
Mechanical forces and ligand binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein	17
Trans-scale live-imaging of an E5.5 mouse embryo using incubator-type biaxial light-sheet microscopy	17
Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens	17
The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity	17
Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer’s model	17
RNA helicase EIF4A1-mediated translation is essential for the GC response	16
Apical dehydration impairs the cystic fibrosis airway epithelium barrier via aβ1-integrin/YAP1 pathway	16
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7	16
De novo network analysis reveals autism causal genes and developmental links to co-occurring traits	16
Tandemly repeated NBPF HOR copies (Olduvai triplets): Possible impact on human brain evolution	16
CC2D1A causes ciliopathy, intellectual disability, heterotaxy, renal dysplasia, and abnormal CSF flow	16
Combining sophisticated fast FLIM, confocal microscopy, and STED nanoscopy for live-cell imaging of tunneling nanotubes	16
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation	16
Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions	16
Molecular mechanisms underlying totipotency	16
Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes	16
Trim66’s paternal deficiency causes intrauterine overgrowth	16
SBDSR126Trescues survival ofsbds−/−zebrafish in a dose-dependent manner independently of Tp53	16
GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation	16
Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network	16
The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast	16
PD-L1 regulates inflammatory programs of macrophages from human pluripotent stem cells	16
Identifying space-resolved proteins of the murine thymus, by combining MALDI-MSI and proteomics	16
Skewed X-inactivation is associated with retinal dystrophy in female carriers ofRPGRmutations	16
Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling	16
Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment	16
MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex	16
NAD+depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia	16
NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation	16
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria	16
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice	16
Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling	16
Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons	16
Trans-differentiation of trophoblast stem cells: implications in placental biology	16
Cholesterol promotesIFNGmRNA expression in CD4+effector/memory cells by SGK1 activation	16
Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes	15
Structure and dynamics of 2x(CENP-A/H4) 2 octasome reveal a possible intermediate in centromeric chromatin	15
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer	15
Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes	15
Mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways	15
Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies	15
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia	15
Breast implant surface topography triggers a chronic-like inflammatory response	15
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling	15
Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport	15
DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance	15
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing	15
DNA methylation predicts infection risk in kidney transplant recipients	15
Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesis	15
NSD3 protein methylation and stabilization transforms human ES cells into variant state	15

Hepatic DKK1-driven steatosis is CD36 dependent	15
Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity	14
Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data	14
Regulation of hPCL3 isoforms’ ubiquitination by TRIM21 in non-small cell lung cancer progression	14
An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation	14
Novel imaging tools to study mitochondrial morphology inCaenorhabditis elegans	14
Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor	14
ATP-independent substrate recruitment to proteasomal degradation in mycobacteria	14
ETV2 induces endothelial, but not hematopoietic, lineage specification in birds	14
SF3B1mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia	14
High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response	14
Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts	14
A targeted sequencing extension for transcript genotyping in single-cell transcriptomics	14
Efficient identification of de novo mutations in family trios: a consensus-based informatic approach	14
Endolysosome-targeted nanoparticle delivery of antiviral therapy for coronavirus infections	14
Segregation of pathways leading to pexophagy	14
DICE: fast and accurate distance-based reconstruction of single-cell copy number phylogenies	14
Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes	14
PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates	13
Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops	13
A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane ofT. brucei	13
Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury	13
Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II	13
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	13
Meiotic DNA exchanges inC. elegansare promoted by proximity to the synaptonemal complex	13
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol	13
Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19	13
Sustained induction of autophagy enhances survival during prolonged starvation in newt cells	13
Correction: Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	13
Cellular zinc status alters chromatin accessibility and binding of p53 to DNA	13
Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress	13
Local tissue mechanics control cardiac pacemaker cell embryonic patterning	13
Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the dystrophic muscle in Duchenne muscular dystrophy	13
The Ragulator complex and lysosomal calcium release are crucial for cell migration	13
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation	13
Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation	13
A multiplexed siRNA screen identifies key kinase signaling networks of brain glia	13
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain	12
Tbx1 plays a critical role in focal adhesion dynamics through paxillin regulation	12
In vitro approaches to study centriole and cilium function in early mouse embryogenesis	12
IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium	12
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation	12
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior	12
Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm	12
Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice	12
Hydroxyurea modulates thiol–disulfide homeostasis in the yeast endoplasmic reticulum	12
Performance and robustness analysis reveals phenotypic trade-offs in yeast	12
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation	12
Yolk-deprivedCaenorhabditis eleganssecure brood size at the expense of competitive fitness	12
FERM domain–containing proteins are active components of the cell nucleus	12
Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions	12
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation	12
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function againstCandida albicans	12
Differential growth regulates asymmetric size partitioning in Caulobacter crescentus	12
DEFA1A3DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection	12
TRIM25 targets p300 for degradation	12
Beneficial and detrimental consequences of AHR activation in intestinal infection	12
MacrophageSult2b1promotes pathological neovascularization in age-related macular degeneration	12
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes	12
Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior	12
Cristae dynamics is modulated in bioenergetically compromised mitochondria	11
Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapes	11
Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing	11
Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice	11
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo	11
Neuropeptide signalling shapes feeding and reproductive behaviours in male Caenorhabditis elegans	11
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes	11
Mature B cells and mesenchymal stem cells control emergency myelopoiesis	11
PARP10 is critical for stress granule initiation	11
Lipid flippases ATP9A and ATP9B form a complex and contribute to the exocytic pathway from the Golgi	11
Mitochondria remodeling during endometrial stromal cell decidualization	11
Replication-associated inversions are the dominant form of bacterial chromosome structural variation	11
α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes	11
Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells	11
TLR-induced STK25 activation promotes IRF5-mediated inflammation	11
Automated staging of zebrafish embryos with deep learning	11
Enzymes of physiological amyloidogenesis control pathological amyloid toxicity	11
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF	11
The −10 region adjacent to open reading frames is a common expression pattern in Deinococcus-Thermus	11
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1	11
The Janus framework of the integrated stress response: from homeostasis to maladaptation	11
Apolipoprotein E intersects with amyloid-β within neurons	11
Subdomains of theHelicobacter pyloriCag T4SS outer membrane core complex exhibit structural independence	11
Fn14 promotes myoblast fusion during regenerative myogenesis	11
Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence	11
Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells	11
Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay	11
Genetic mutation ofCep76results in male infertility due to abnormal sperm tail composition	11
IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway	11
Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs	11
WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium	10
Regulation of alternative splicing and polyadenylation in neurons	10
Scalable workflows for high-throughput respirometry	10
A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95	10
Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration	10