Life Science Alliance

Article	Citations
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells	552
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer	75
A FIJI macro for quantifying pattern in extracellular matrix	74
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation	71
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids	67
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD	65
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages	62
A serum proteome signature to predict mortality in severe COVID-19 patients	61
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells	59
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression	51
Robust production of uniform human cerebral organoids from pluripotent stem cells	47
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters	47
SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration	42
Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution	41
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo	38
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program	37
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis	37
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes	36
An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites	36
An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR	35
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family	34
FIREWORKS: a bottom-up approach to integrative coessentiality network analysis	31
Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis	31
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway	31
Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation	29

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade	29
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria	28
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice	27
CellMixS: quantifying and visualizing batch effects in single-cell RNA-seq data	27
Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes	26
Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1	26
The DREAM complex represses growth in response to DNA damage in Arabidopsis	26
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling	26
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity	26
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19	25
Leishmania-infected macrophages release extracellular vesicles that can promote lesion development	25
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system	25
PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands	25
Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer	24
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	24
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19	24
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients	24
Mapping the micro-proteome of the nuclear lamina and lamina-associated domains	24
EBV renders B cells susceptible to HIV-1 in humanized mice	23
Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis	23
Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis	23
Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology	23
The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity	23
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma	23
Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism	23
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression	22
multicrispr: gRNA design for prime editing and parallel targeting of thousands of targets	22
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells	22
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy	21
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella	21
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape	21
Cancer-associated cells release citrate to support tumour metastatic progression	21
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation	20
Exploiting somatic piRNAs in Bemisia tabaci enables novel gene silencing through RNA feeding	20
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers	20
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors	20
CryoEM structure ofDrosophilaflight muscle thick filaments at 7 Å resolution	20
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1	20
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer	19
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting	19
Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42toxicity	19
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus	19
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection	19
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo	18
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data	18
Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS	18
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis	18
Attenuation of cGAS/STING activity during mitosis	18
The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies	18
Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation	18

Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity	18
The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation	18
Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase	18
Role of opioid signaling in kidney damage during the development of salt-induced hypertension	17
Human BRCA pathogenic variants were originated during recent human history	17
Serine palmitoyltransferase assembles at ER–mitochondria contact sites	17
Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration	17
The different activities of RNA G-quadruplex structures are controlled by flanking sequences	17
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia	17
Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells	17
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels	17
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase	16
Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds	16
Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans	16
ScRNA-seq expression ofIFI27andAPOC2identifies four alveolar macrophage superclusters in healthy BALF	16
Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila	16
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells	16
Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines	16
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques	16
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails	16
Chromosome length and gene density contribute to micronuclear membrane stability	16
Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies	15
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway	15
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy	15
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx	15
Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells	15
Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection	15
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH	15
In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer	15
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations	15
Regulation of axonal morphogenesis by the mitochondrial protein Efhd1	15
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories	15
Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes	15
Thymosin α1 protects from CTLA-4 intestinal immunopathology	15
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress	15
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade	14
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells	14
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network	14
Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay	14
Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor	14
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes	14
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19	14
Insulin signaling mediates neurodegeneration in glioma	14
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer	14
Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes	14
Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax	14
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection	14
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19	14
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids	14
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells	14
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling	14
Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation	14
Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins	14
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F	14
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors	13
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection	13
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila	13
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP	13
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice	13
Fast but not furious: a streamlined selection method for genome-edited cells	13
Elevated glucose increases genomic instability by inhibiting nucleotide excision repair	13
Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein	13
Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe	13
Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells	13
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7	13
The actin regulator profilin 1 is functionally associated with the mammalian centrosome	13
Islet Gene View—a tool to facilitate islet research	13
Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies	13
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow	12
BRD2 regulation of sigma-2 receptor upon cholesterol deprivation	12
Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation	12
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1	12
Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect	12
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2	12
Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup	12
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells	12
Identification of human gene research articles with wrongly identified nucleotide sequences	12
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model	12
SCFCdc4ubiquitin ligase regulates synaptonemal complex formation during meiosis	12
Multifaceted regulation of hepatic lipid metabolism by YY1	12

Reduced RNA turnover as a driver of cellular senescence	12
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets	12
Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice	12
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers	12
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models	11
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly	11
Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation	11
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity	11
Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse	11
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage	11
Cell-autonomousToxoplasmakilling program requires Irgm2 but not its microbe vacuolar localization	11
The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells	11
Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice	11
BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells	11
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF	11
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells	11
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis	11
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response	11
MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiation	11
Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2	11
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis	11
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells	11
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA system	10
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites	10
Peptide-based quorum sensing systems in Paenibacillus polymyxa	10
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes	10
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer	10
The HDL particle composition determines its antitumor activity in pancreatic cancer	10
The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration	10
TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition	10
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome	10
A novel canis lupus familiaris reference genome improves variant resolution for use in breed-specific GWAS	10
Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells	10
Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core	10
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C	10
PGE2accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking	10
Cell-free expression of the outer membrane protein OprF of Pseudomonas aeruginosa for vaccine purposes	10
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses	10
NovelDNM1Lvariants impair mitochondrial dynamics through divergent mechanisms	10
The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health	10
A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ	10
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction	10
Structure and conformational dynamics of Clostridioides difficile toxin A	10
The m6A(m)-independent role of FTO in regulating WNT signaling pathways	10
Incipient sympatric speciation in wild barley caused by geological-edaphic divergence	10
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission	10
Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19	9
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4	9
Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast	9
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy	9
The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites	9
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures	9
Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch	9
Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling	9
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin	9
ATAD2 controls chromatin-bound HIRA turnover	9
Tricalbin proteins regulate plasma membrane phospholipid homeostasis	9
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis	9
AGO1 regulates pericentromeric regions in mouse embryonic stem cells	9
Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from India	9
Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes	9
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration	9
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia	9
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality	9
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats	9
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart	9
Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons	9
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells	9
Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism	9
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis	9
MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation	8
Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules	8
Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres	8
A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8	8
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy	8
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy	8
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF	8
A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth	8
MET∆14 promotes a ligand-dependent, AKT-driven invasive growth	8
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching	8
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity	8
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation	8
UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma	8
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions	8
HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells	8
Quantitative profiling of adaptation to cyclin E overproduction	8
SustainedHelicobacter pyloriinfection accelerates gastric dysplasia in a mouse model	8
Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women	8
Expression regulation of genes is linked to their CpG density distributions around transcription start sites	8
Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly	8
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors	8
Origin and segregation of the human germline	8
Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulse	8
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy	8
Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast	8