Life Science Alliance

Article	Citations
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease	66
An immune-based tool platform for in vivo cell clearance	65
Correction: Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome	58
The ERK activator, BCI, inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement	44
Gene-regulation modules in nonalcoholic fatty liver disease revealed by single-nucleus ATAC-seq	43
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro	41
FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis	39
Mitochondrial phosphoproteomes are functionally specialized across tissues	37
Whole genome sequencing of drug resistanceMycobacterium tuberculosisfrom extra-pulmonary sites	37
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway	37
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP	36
Metabolic adaptation pilots the differentiation of human hematopoietic cells	36
Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia	36
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity	35
Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescence	35
GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells	33
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection	33
Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress	33
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway	33
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau	30
Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression	29
Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish	29
B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses	28
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations	28
Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification	28

An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65	27
A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+leak but activates SERCA2a Ca2+uptake	27
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models	27
Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cells	27
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms	27
The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization	27
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest	27
Peripheral immune system modulates Purkinje cell degeneration in Niemann–Pick disease type C1	26
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma	26
The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delays	26
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses	25
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathies	25
The memory of airway epithelium damage in smokers and COPD patients	25
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine	24
Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes	24
ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis	24
Unique activities of two overlappingPAX6retinal enhancers	24
Inflammasome is a central player in B cell development and homing	24
Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer	24
Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	24
Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect	23
The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors	23
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing	23
Correction: Apolipoprotein E intersects with amyloid-β within neurons	23
A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2	22
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis	22
Full-length MSP1 is a major target of protective immunity after controlled human malaria infection	22
Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins	22
Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis	22
A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells	21
Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells	21
Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter	21
The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation	21
OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processes	21
Single variant, yet “double trouble”: TSC and KBG syndrome because of a large de novo inversion	21
SLAMF6 compartmentalization enhances T cell functions	21
Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis	21
The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis	20
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope	20
Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5	19
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy	19
Lineage tracing reveals fate bias and transcriptional memory in human B cells	19
Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores inSaccharomyces cerevisiae	19
Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activation	19
Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation	19
Structural basis of translation inhibition by a valine tRNA-derived fragment	18
Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice	18
SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment	18
Off-targets of BRAF inhibitors disrupt endothelial signaling and vascular barrier function	18
Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ doses	18

BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes identified through gene network analysis	18
RAS and PP2A activities converge on epigenetic gene regulation	17
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures	17
Identification of a novel enhancer essential forSatb1expression in TH2 cells and activated ILC2s	17
EZH2 controls epicardial cell migration during heart development	17
RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping	17
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors	17
Trans-scale live-imaging of an E5.5 mouse embryo using incubator-type biaxial light-sheet microscopy	17
Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A	17
DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications	17
Interconnections between m6A RNA modification, RNA structure, and protein–RNA complex assembly	17
Horizontal transfer of therfbcluster inLeptospirais a genetic determinant of serovar identity	17
Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins	16
ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells	16
VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis	16
Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling	16
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation	16
PrgE: an OB-fold protein from plasmid pCF10 with striking differences to prototypical bacterial SSBs	16
Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophages	16
Tricalbin proteins regulate plasma membrane phospholipid homeostasis	16
Mechanical forces and ligand binding modulatePseudomonas aeruginosaPilY1 mechanosensitive protein	16
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice	16
Renal antiporter ClC-5 regulates collagen I/IV through the β-catenin pathway and lysosomal degradation	16
Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands	16
Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma	16
The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity	16
Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells	16
Skewed X-inactivation is associated with retinal dystrophy in female carriers ofRPGRmutations	15
Evaluation of the correctable decoding sequencing as a new powerful strategy for DNA sequencing	15
The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis	15
Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBD	15
Epigenetic signals that direct cell type–specific interferon beta response in mouse cells	15
ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma	15
Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens	15
Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva	15
PD-L1 regulates inflammatory programs of macrophages from human pluripotent stem cells	15
Chromosome-specific barcode system with centromeric repeat in cultivated soybean and wild progenitor	15
Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer’s model	15
Preeclampsia promotes autism in offspring via maternal inflammation and fetal NFκB signaling	15
CC2D1A causes ciliopathy, intellectual disability, heterotaxy, renal dysplasia, and abnormal CSF flow	14
Apical dehydration impairs the cystic fibrosis airway epithelium barrier via aβ1-integrin/YAP1 pathway	14
Tandemly repeated NBPF HOR copies (Olduvai triplets): Possible impact on human brain evolution	14
Combining sophisticated fast FLIM, confocal microscopy, and STED nanoscopy for live-cell imaging of tunneling nanotubes	14
PathogenicLRRK2mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons	14
Breast implant surface topography triggers a chronic-like inflammatory response	14
DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance	14
NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation	14
NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling	14
DrosophilapVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes	14
Conserved exchange of paralog proteins during neuronal differentiation	14
FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion	14
Trans-differentiation of trophoblast stem cells: implications in placental biology	14
GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation	14
MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex	14
Trim66’s paternal deficiency causes intrauterine overgrowth	14
RNA helicase EIF4A1-mediated translation is essential for the GC response	14
Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment	14
Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions	14
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites	14
The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast	14
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival	14
SBDSR126Trescues survival ofsbds−/−zebrafish in a dose-dependent manner independently of Tp53	14
Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies	14
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia	13
De novo network analysis reveals autism causal genes and developmental links to co-occurring traits	13
MKP-1 modulates ubiquitination/phosphorylation of TLR signaling	13
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer	13
Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network	13
DNA methylation predicts infection risk in kidney transplant recipients	13
NAD+depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia	13
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing	13
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7	13
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching	13
Choroid plexus APP regulates adult brain proliferation and animal behavior	13
Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes	13
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria	13
Cholesterol promotesIFNGmRNA expression in CD4+effector/memory cells by SGK1 activation	13
Molecular mechanisms underlying totipotency	13
Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes	13
Mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways	12

Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the dystrophic muscle in Duchenne muscular dystrophy	12
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH	12
A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane ofT. brucei	12
Novel imaging tools to study mitochondrial morphology inCaenorhabditis elegans	12
ATP-independent substrate recruitment to proteasomal degradation in mycobacteria	12
Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity	12
Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor	12
PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates	12
Efficient identification of de novo mutations in family trios: a consensus-based informatic approach	12
DICE: fast and accurate distance-based reconstruction of single-cell copy number phylogenies	12
Regulation of hPCL3 isoforms’ ubiquitination by TRIM21 in non-small cell lung cancer progression	12
NSD3 protein methylation and stabilization transforms human ES cells into variant state	12
An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation	12
Segregation of pathways leading to pexophagy	12
Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes	12
High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response	12
Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport	12
The expression of essential selenoproteins during development requires SECIS-binding protein 2–like	12
A targeted sequencing extension for transcript genotyping in single-cell transcriptomics	12
ETV2 induces endothelial, but not hematopoietic, lineage specification in birds	12
Hepatic DKK1-driven steatosis is CD36 dependent	12
Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesis	12
Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity	12
Meiotic DNA exchanges inC. elegansare promoted by proximity to the synaptonemal complex	12
Endolysosome-targeted nanoparticle delivery of antiviral therapy for coronavirus infections	12
SF3B1mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia	12
Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops	12
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol	12
Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts	12
Local tissue mechanics control cardiac pacemaker cell embryonic patterning	12
A multiplexed siRNA screen identifies key kinase signaling networks of brain glia	12
DEFA1A3DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection	11
Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogenetics	11
The Ragulator complex and lysosomal calcium release are crucial for cell migration	11
Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells	11
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal	11
Tbx1 plays a critical role in focal adhesion dynamics through paxillin regulation	11
IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium	11
Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation	11
Correction: Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	11
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation	11
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin	11
Sustained induction of autophagy enhances survival during prolonged starvation in newt cells	11
Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice	11
Yolk-deprivedCaenorhabditis eleganssecure brood size at the expense of competitive fitness	11
TLR-induced STK25 activation promotes IRF5-mediated inflammation	11
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation	11
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation	11
Cellular zinc status alters chromatin accessibility and binding of p53 to DNA	11
Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19	11
FERM domain–containing proteins are active components of the cell nucleus	11
Hydroxyurea modulates thiol–disulfide homeostasis in the yeast endoplasmic reticulum	11
Automated staging of zebrafish embryos with deep learning	11
Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior	11
Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt	11
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo	11
Performance and robustness analysis reveals phenotypic trade-offs in yeast	11
TRIM25 targets p300 for degradation	11
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function againstCandida albicans	10
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	10
Enhanced locomotor recovery in mice lacking GlcNAc6ST1 and GlcNAc6ST4 following spinal cord injury	10
Neuropeptide signalling shapes feeding and reproductive behaviours in male Caenorhabditis elegans	10
Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II	10
IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway	10
Mitochondria remodeling during endometrial stromal cell decidualization	10
Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing	10
Mature B cells and mesenchymal stem cells control emergency myelopoiesis	10
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients	10
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation	10
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes	10
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior	10
Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm	10
Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs	10
Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells	10
α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes	10
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes	10
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells	10
MacrophageSult2b1promotes pathological neovascularization in age-related macular degeneration	10
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain	10
Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions	10
Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapes	10
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1	10
The −10 region adjacent to open reading frames is a common expression pattern in Deinococcus-Thermus	10
Replication-associated inversions are the dominant form of bacterial chromosome structural variation	10
WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium	9
Regulation of alternative splicing and polyadenylation in neurons	9
Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans	9
Optogenetic control of pheromone gradients and mating behavior in budding yeast	9
The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells	9
The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density	9
The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress	9
HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells	9
The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program	9
Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration	9
Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases	9