Life Science Alliance

Article	Citations
Generation of marmoset primordial germ cell–like cells under chemically defined conditions	106
Molecular insights into high-altitude adaption and acclimatisation ofAporrectodea caliginosa	78
New algorithms for accurate and efficient de novo genome assembly from long DNA sequencing reads	75
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation	71
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity	70
Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila muscles	49
The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import	46
Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy	45
H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning inHydra	44
Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers	42
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade	40
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP	39
Epithelial-specific loss of Smad4 alleviates the fibrotic response in an acute colitis mouse model	38
Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish	36
MacrophageSult2b1promotes pathological neovascularization in age-related macular degeneration	34
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function againstCandida albicans	33
FAT10 and NUB1L cooperate to activate the 26S proteasome	31
RedRibbon: A new rank–rank hypergeometric overlap for gene and transcript expression signatures	30
Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome	29
Simultaneous solving high-resolution structures of various enzymes from human kidney microsomes	29
Structural insights into CED-3 activation	28
Spt5 interacts genetically with Myc and is limiting for brain tumor growth inDrosophila	28
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila	28
Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome	27
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control	27

Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19	26
The nucleolar phase of signal recognition particle assembly	25
Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression	25
Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes	25
Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns	24
Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase	24
Improving the computation efficiency of polygenic risk score modeling: faster in Julia	23
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19	23
FERM domain–containing proteins are active components of the cell nucleus	23
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway	22
Incomplete activation ofAlyrefandGabpb1leads to preimplantation arrest in cloned mouse embryos	22
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells	22
Single-domain antibody screening by isPLA-seq	22
Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions	22
Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish	22
Functional annotation of noncoding mutations in cancer	22
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza	22
2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assembly	21
An immune-based tool platform for in vivo cell clearance	21
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway	21
Causal links of α-thalassemia indices and cardiometabolic traits and diabetes: MR study	21
Nodal andchurchill1position the expression of a notch ligand duringXenopusgerm layer segregation	21
IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium	21
Plasma proteome dynamics of COVID-19 severity learnt by a graph convolutional network of multi-scale topology	20
Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m5C at GCU motifs	20
The role ofLimch1alternative splicing in skeletal muscle function	19
Whole genome sequencing of drug resistanceMycobacterium tuberculosisfrom extra-pulmonary sites	19
Gene-regulation modules in nonalcoholic fatty liver disease revealed by single-nucleus ATAC-seq	19
Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt	19
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior	19
GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells	18
Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis	18
TRIM25 targets p300 for degradation	18
The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization	18
Contribution of the Golgi apparatus in morphogenesis of a virus-induced cytopathic vacuolar system	18
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes	18
High-resolution structure of a fish aquaporin reveals a novel extracellular fold	18
Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior	18
Neuropeptide signalling shapes feeding and reproductive behaviours in male Caenorhabditis elegans	17
Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II	17
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity	17
Brd4::Nutm1fusion gene initiates NUT carcinoma in vivo	17
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells	17
Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells	17
Human T-cell activation withToxoplasma gondiiantigens loaded in maltodextrin nanoparticles	17
Revisiting degron motifs in human AURKA required for its targeting by APC/CFZR1	17
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques	17
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting	16
Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines	16
HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress	16

Timing of TORC1 inhibition dictates Pol III involvement inCaenorhabditis eleganslongevity	16
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models	16
Comparative functional genomics identifies unique molecular features of EPSCs	16
The different activities of RNA G-quadruplex structures are controlled by flanking sequences	15
Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia	15
MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea	15
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells	15
Insight into the mechanism of DNA synthesis by human terminal deoxynucleotidyltransferase	15
Performance and robustness analysis reveals phenotypic trade-offs in yeast	15
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations	15
DEFA1A3DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection	15
Systems genetics analysis of human body fat distribution genes identifies adipocyte processes	15
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation	15
Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling	14
An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65	14
The C-terminal tail of CSNAP attenuates the CSN complex	14
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress	14
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication	14
Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exercise	14
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo	14
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection	14
arfAantisense RNA regulates MscL excretory activity	14
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo	14
Cdh5-lineage–independent origin of dermal lymphatics shown by temporally restricted lineage tracing	14
Catalytic mechanism of the zinc-dependent MutL endonuclease reaction	14
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations	14
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease	14
Distant sequence regions of JBP1 contribute to J-DNA binding	14
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain	14
Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes	13
The origin, evolution, and molecular diversity of the chemokine system	13
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis	13
Metabolic adaptation pilots the differentiation of human hematopoietic cells	13
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes inC9orf72ALS/FTD models	13
A multiomic characterization of the leukemia cell line REH using short- and long-read sequencing	13
Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility	13
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer	13
Human BRCA pathogenic variants were originated during recent human history	13
Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation	12
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis	12
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response	12
Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis	12
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation	12
Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells	12
Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogenetics	12
Toward an understanding of glucose metabolism in radial glial biology and brain development	12
Statistical guidelines for quality control of next-generation sequencing techniques	12
Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK mice	12
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF	12
Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival	12
Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy	12
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology	11
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer	11
Dose-dependent phosphorylation and activation of Hh pathway transcription factors	11
Regulation of proteostasis by sleep through autophagy inDrosophilamodels of Alzheimer’s disease	11
Full-length transcript alterations in human bronchial epithelial cells withU2AF1S34F mutations	11
Enhancer mutations modulate the severity of chemotherapy-induced myelosuppression	11
Quantitative profiling of adaptation to cyclin E overproduction	11
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase	11
pyRBDome: a comprehensive computational platform for enhancing RNA-binding proteome data	11
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+T cells	11
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau	11
Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescence	11
In vivo probing of SECIS-dependent selenocysteine translation in Archaea	11
Nanoscale imaging of DNA-RNA identifies transcriptional plasticity at heterochromatin	11
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms	11
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes	11
Passive diffusion accounts for the majority of intracellular nanovesicle transport	11
Morphological correlates of synaptic protein turnover in the mouse brain	11
Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells	10
The ERK activator, BCI, inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement	10
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter	10
Yolk-deprivedCaenorhabditis eleganssecure brood size at the expense of competitive fitness	10
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients	10
The m6A(m)-independent role of FTO in regulating WNT signaling pathways	10
MAP4K4 regulates forces at cell–cell and cell–matrix adhesions to promote collective cell migration	10
Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification	10
Mitochondrial phosphoproteomes are functionally specialized across tissues	10
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation	10
The HDL particle composition determines its antitumor activity in pancreatic cancer	10

Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression	10
Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm	10
PNKP is required for maintaining the integrity of progenitor cell populations in adult mice	10
Automated staging of zebrafish embryos with deep learning	10
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model	10
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal	10
Mass spectrometry–based proteomic exploration of diverse murine macrophage cellular models	10
Genetic and compound screens uncover factors modulating cancer cell response to indisulam	10
Concatemer-assisted stoichiometry analysis: targeted mass spectrometry for protein quantification	10
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage	10
Myc controls NK cell development, IL-15-driven expansion, and translational machinery	10
B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses	10
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function	10
Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5	9
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses	9
Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells	9
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease	9
Correction: Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops	9
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	9
Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB	9
Differential effects of translation inhibitors onPlasmodium bergheiliver stage parasites	9
Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma	9
Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells	9
Transducing compressive forces into cellular outputs in cancer and beyond	9
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway	9
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance	9
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing	9
Correction: Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	9
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19	9
The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine	9
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme	9
Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress	9
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF	9
Cryo-EM structures reveal the H+/citrate symport mechanism ofDrosophilaINDY	9
Correction: Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome	9
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins	9
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis	9
Rolf Jessberger: cohesin, telomeres, & germ cells	9
Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice	9
ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance	9
DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity	9
Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival	9
Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress	9
The DREAM complex represses growth in response to DNA damage in Arabidopsis	9
Characterization of Na+currents regulating intrinsic excitability of optic tectal neurons	8
Mature B cells and mesenchymal stem cells control emergency myelopoiesis	8
The highly improved genome ofIxodes scapulariswith X and Y pseudochromosomes	8
Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42toxicity	8
Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type	8
Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay	8
Cristae dynamics is modulated in bioenergetically compromised mitochondria	8
Unique activities of two overlappingPAX6retinal enhancers	8
Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2α complexes	8
RA-induced prominence-specific response resulted in distinctive regulation of Wnt and osteogenesis	8
Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension	8
Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity	8
Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis	8
Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis	8
Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice	8
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions	8
Transcellular blood–brain barrier disruption in malaria-induced reversible brain edema	8
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling	8
Gapless provides combined scaffolding, gap filling, and assembly correction with long reads	8
Axon terminals control endolysosome diffusion to support synaptic remodelling	8
Peripheral immune system modulates Purkinje cell degeneration in Niemann–Pick disease type C1	8
NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma	8
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease	8
Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice	8
Inflammasome is a central player in B cell development and homing	8
Structure and conformational dynamics of Clostridioides difficile toxin A	8
Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival	8
Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases	8
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation	8
Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)	8
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea	8
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing	8
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma	8
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis	7
A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2	7
Genetic mutation ofCep76results in male infertility due to abnormal sperm tail composition	7
Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection	7
Mutation-agnostic RNA interference with engineered replacement rescuesTmc1-related hearing loss	7
Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer	7
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma	7
Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes	7
Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26	7
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation	7
Full-length MSP1 is a major target of protective immunity after controlled human malaria infection	7
Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis	7
Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity	7
Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells	7
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes	7
SLAMF6 compartmentalization enhances T cell functions	7
A protocol for single nucleus RNA-seq from frozen skeletal muscle	7
2024 reviewer index	7