Life Science Alliance

Article	Citations
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer	94
A FIJI macro for quantifying pattern in extracellular matrix	86
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids	78
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells	73
A serum proteome signature to predict mortality in severe COVID-19 patients	70
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages	68
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression	53
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters	48
An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites	45
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo	44
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program	40
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	40
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family	39
Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis	39
FIREWORKS: a bottom-up approach to integrative coessentiality network analysis	38
Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation	38
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway	38
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade	34
The DREAM complex represses growth in response to DNA damage in Arabidopsis	32
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity	31
CellMixS: quantifying and visualizing batch effects in single-cell RNA-seq data	30
Mapping the micro-proteome of the nuclear lamina and lamina-associated domains	29
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19	28
PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands	28
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients	28

Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system	28
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19	27
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape	26
Cancer-associated cells release citrate to support tumour metastatic progression	25
Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42toxicity	25
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma	25
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors	25
The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies	25
Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis	24
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer	24
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1	24
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails	24
Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines	23
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation	23
Chromosome length and gene density contribute to micronuclear membrane stability	22
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting	22
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy	22
ScRNA-seq expression ofIFI27andAPOC2identifies four alveolar macrophage superclusters in healthy BALF	22
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade	22
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection	22
Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells	22
Serine palmitoyltransferase assembles at ER–mitochondria contact sites	21
Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe	21
Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup	21
Islet Gene View—a tool to facilitate islet research	21
Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes	20
Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans	20
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis	20
Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration	20
Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies	19
Human BRCA pathogenic variants were originated during recent human history	19
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo	19
Reduced RNA turnover as a driver of cellular senescence	19
Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase	19
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH	19
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling	19
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx	18
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations	18
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia	18
Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila	18
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells	18
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7	18
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy	18
The different activities of RNA G-quadruplex structures are controlled by flanking sequences	18
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids	18
Elevated glucose increases genomic instability by inhibiting nucleotide excision repair	18
Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2	17
Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins	17
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques	17
The actin regulator profilin 1 is functionally associated with the mammalian centrosome	17

RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes	17
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase	17
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19	17
Identification of human gene research articles with wrongly identified nucleotide sequences	17
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1	17
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress	17
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors	16
The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health	16
Tricalbin proteins regulate plasma membrane phospholipid homeostasis	16
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection	16
A novel canis lupus familiaris reference genome improves variant resolution for use in breed-specific GWAS	16
Insulin signaling mediates neurodegeneration in glioma	16
Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay	16
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories	16
Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes	16
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers	15
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells	15
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells	15
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice	15
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model	15
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2	15
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells	15
Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation	15
Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice	15
Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells	15
Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection	15
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response	15
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity	15
Multifaceted regulation of hepatic lipid metabolism by YY1	14
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA system	14
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila	14
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis	14
Structure and conformational dynamics of Clostridioides difficile toxin A	14
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19	14
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission	14
The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites	14
Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension	14
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP	14
Structure-based design and characterization of Parkin-activating mutations	14
Fast but not furious: a streamlined selection method for genome-edited cells	14
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection	14
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network	14
Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation	14
Origin and segregation of the human germline	14
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage	14
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets	13
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme	13
The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration	13
Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae	13
BRD2 regulation of sigma-2 receptor upon cholesterol deprivation	13
SCFCdc4ubiquitin ligase regulates synaptonemal complex formation during meiosis	13
Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19	13
Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used	13
MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation	13
Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation	13
Cell-free expression of the outer membrane protein OprF of Pseudomonas aeruginosa for vaccine purposes	13
Cross talk between glucose metabolism and immunosuppression in IFN-γ–primed mesenchymal stem cells	13
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome	12
Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis	12
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow	12
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy	12
Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling	12
The HDL particle composition determines its antitumor activity in pancreatic cancer	12
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells	12
Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome	12
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models	12
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration	12
Mitochondrial phosphoproteomes are functionally specialized across tissues	12
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4	12
TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition	12
Cell-autonomousToxoplasmakilling program requires Irgm2 but not its microbe vacuolar localization	12
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity	12
Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulse	12
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF	12
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy	11
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction	11
Quantitative profiling of adaptation to cyclin E overproduction	11
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs	11
Expression regulation of genes is linked to their CpG density distributions around transcription start sites	11
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly	11

UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma	11
The m6A(m)-independent role of FTO in regulating WNT signaling pathways	11
NovelDNM1Lvariants impair mitochondrial dynamics through divergent mechanisms	11
A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ	11
Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells	11
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions	11
Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo	11
Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women	11
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation	10
Functional and structural deficiencies of Gemin5 variants associated with neurological disorders	10
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells	10
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1	10
Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival	10
ATAD2 controls chromatin-bound HIRA turnover	10
Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system	10
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites	10
Horizontal transfer of therfbcluster inLeptospirais a genetic determinant of serovar identity	10
Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from India	10
Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice	10
The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion	10
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin	10
Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann–Pick disease type C1 mice	10
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats	10
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis	10
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart	10
Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core	10
Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons	10
Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding	10
Inflammasome is a central player in B cell development and homing	10
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses	10
Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases	10
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis	10
Synthetic evolution of herbicide resistance using a T7 RNAP–based random DNA base editor	10
MET∆14 promotes a ligand-dependent, AKT-driven invasive growth	9
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis	9
Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres	9
Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation	9
Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma	9
INPP5K and Atlastin-1 maintain the nonuniform distribution of ER–plasma membrane contacts in neurons	9
MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC	9
Gametic specialization of centromeric histone paralogs in Drosophila virilis	9
In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood	9
Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast	9
SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members	9
Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation	9
Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch	9
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy	9
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF	9
Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection	9
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia	9
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching	9
Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules	9
Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection	9
CDCP1 promotes compensatory renal growth by integrating Src and Met signaling	9
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures	9
AGO1 regulates pericentromeric regions in mouse embryonic stem cells	9
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy	9
Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II	9
Segregation of pathways leading to pexophagy	9
Semaphorin 6D–expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung	9
Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition	9
MICA: a multi-omics method to predict gene regulatory networks in early human embryos	9
Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression	8
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance	8
ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection	8
Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival	8
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations	8
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes	8
miR-329– and miR-495–mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons	8
Miro GTPase domains regulate the assembly of the mitochondrial motor–adaptor complex	8
Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation	8
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosis	8
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway	8
Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma	8
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation	8
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response	8
Myc controls NK cell development, IL-15-driven expansion, and translational machinery	8
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza	8
Drosophilainsulator proteins exhibit in vivo liquid–liquid phase separation properties	8
Loss of autism-candidate CHD8 perturbs neural crest development and intestinal homeostatic balance	8
Genome analysis of Legionella pneumophila ST23 from various countries reveals highly similar strains	8
Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins	8
Comparative membrane proteomics reveals diverse cell regulators concentrated at the nuclear envelope	8
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors	8
A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8	8
HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells	8
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease	8
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells	8
Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes	8
Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection	8
Biallelic structural variations withinFGF12detected by long-read sequencing in epilepsy	8
Epigenetic signals that direct cell type–specific interferon beta response in mouse cells	8
Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequency	8
Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns	7
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo	7