Circulation-Genomic and Precision Medicine

Article	Citations
Editorial Board	91
Relationships of Circulating Plasma Metabolites With the QT Interval in a Large Population Cohort	50
Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction	42
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects	40
Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation	39
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy	33
Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population	32
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy	30
Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk	29
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	29
Role of TBX20 Truncating Variants in Dilated Cardiomyopathy and Left Ventricular Noncompaction	28
Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants	28
Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia	27
Calmodulinopathy Associated Long QT Syndrome, Hypertrophic Cardiomyopathy With Excessive Trabeculation in a 14-Year-Old Girl Presenting With Ventricular Fibrillation	26
Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems	26
Plasma Protein Profile Associated With a Family History of Early-Onset Coronary Heart Disease	24
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies	24
Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty	23
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors	23
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy	23
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	23
Editors and Editorial Board	22
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	22
Using Omics to Identify Novel Therapeutic Targets in Heart Failure	22
Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease	22

Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	21
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	21
Resource of Gene Expression Data From a Multiethnic Population Cohort of Induced Pluripotent Stem Cell–Derived Cardiomyocytes	21
Hereditary Hemorrhagic Telangiectasia Prevalence Estimates Calculated From GnomAD Allele Frequencies of Predicted Pathogenic Variants in ENG and	21
DNA Methylation-Based Biomarkers of Protein Levels and Cardiovascular Disease Risk: Opportunities and Challenges for Precision Cardiology	20
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy	20
Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis	19
End Stage Mitochondrial Cardiomyopathy and Heart Transplantation Due to Biallelic Pathogenic C1QBP Variants	19
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant	18
Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy	17
Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort	17
Exome Sequencing Highlights a Potential Role for Concealed Cardiomyopathies in Youthful Sudden Cardiac Death	17
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy	17
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch	17
Monomorphic and Polymorphic Ventricular Arrhythmias in Heterozygous Calsequestrin-2 Mutation Carriers	16
In Memoriam: Prof. Dr. Jeanette Erdmann (1965–2023)	16
Prevalence of Pathogenic Variants in Cardiomyopathy-Associated Genes in Myocarditis	16
Impact of GLA Variant Classification on the Estimated Prevalence of Fabry Disease: A Systematic Review and Meta-Analysis of Screening Studies	16
Phenotypic Characterization of Timothy Syndrome Caused by the CACNA1C p.Gly402Ser Variant	16
Yield of Genetic Testing for Long-QT Syndrome in Elderly Patients With Torsades de Pointes	16
Phenotype of ASDs Associated With 4p16 Risk Locus and Novel Genome-Wide Associations of ASD Patients in the Finnish Population	16
Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases	15
Differential Deep RNA Sequencing for Diagnostic Detection of Microbial Infections in Inflammatory Cardiomyopathy	15
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial	15
Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors	15
Pregnancy Outcomes in Females With Dilated Cardiomyopathy–Associated Rare Genetic Variants	14
Clinical Utility of Protein Language Models in Resolution of Variants of Uncertain Significance in KCNQ1, KCNH2 , and SCN5A Compared With	14
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes	14
Clinical Outcome in KLHL24 Cardiomyopathy	14
Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics	14
Correction to: Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations	14
Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential	14
Population Genomic Screening and Improved Lipid Management in Patients With Familial Hypercholesterolemia	13
Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study	13
Large-Scale Proteomics-Based Risk Score for the Prediction of Incident Cardio-Kidney-Metabolic Disease Risk	13
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	13
Splicing Functional Assays Into the Genetic Testing Pipeline	13
Development and Implementation of an Integrated Preclinical Atherosclerosis Database	12
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy	12
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome	12
DiscoVari : A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes	12
Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association	11
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	11
Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension	11
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	11
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	10
Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease	10
Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems	10
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	10
Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models	10

Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study	10
Multi-Population Genome-Wide Association Study Identifies Novel Loci for Bicuspid Aortic Valve and Reveals Shared Genetic Architecture with Aortopathies	9
Analysis of TTN Truncating Variants in >74 000 Cases Reveals New Clinically Relevant Gene Regions	9
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†	9
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and	9
Digging Deeper Into Cardiovascular Plasma Proteomics: Opportunities and Limitations of Current Platforms	9
Value of Genetic Testing for Lipoprotein(a) Variants	9
Role of Genetic Testing for Cardiomyopathies in Pediatric Patients With Left Ventricular Dysfunction Secondary to Chemotherapy	9
Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease	9
Precision Medicine and the FDA Modernization Act 2.0: Catalyzing Innovation in Cardiovascular Therapy	8
Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin ( DES )-Associated Cardiomyopathy	8
Associations Between Genetic Variation in the Targets of Low-Density Lipoprotein–Lowering Drugs and Rheumatoid Arthritis	8
Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating MYBPC3 Founder Variant Carriers	8
Familial Aggregation Studies: A Valuable Tool in the Genetic Toolbox	8
Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension	8
Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies	8
Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation	8
On Penetrance Estimation in Family, Clinical, and Population Cohorts	8
Titin Allelic Expression and Protein Processing Pathways in Early-Stage Dilated Cardiomyopathy Patients With Truncating Titin Variants	8
Prevalence and Disease Expression of Pathogenic and Likely Pathogenic Variants Associated With Inherited Cardiomyopathies in the General Population	8
Enhancing the Detection and Care of Heterozygous Familial Hypercholesterolemia in Primary Care: Cost-Effectiveness and Return on Investment	8
Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories	8
Efficacy and Safety of ARRY-371797 in LMNA -Related Dilated Cardiomyopathy: A Phase 2 Study	8
Harnessing the Potential of Genetics to Understand the Impact of Sleep Apnea on Cardiovascular Risk	8
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States	7
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study	7
Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin	7
Correction to: Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	7
Enhancing the Prediction Power of Polygenic Risk Scores in Genetically Diverse Coronary Heart Disease	7
Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study	7
The Genetic Basis of Primary Cardiomyopathies in Childhood: Implications for Clinical Genetic Testing	7
Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD	7
Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis	7
Long-Term Effects of Mavacamten on Patients Based on Hypertrophic Cardiomyopathy Pathogenic Genetic Variant Status: Insights From VALOR-HCM Trial	7
Patient-Scientist Perspective on Developing Genetic Therapies for Marfan Syndrome	7
Polygenic Risk in Families With Dilated Cardiomyopathy	6
Genetic Basis of Left Ventricular Noncompaction	6
Human Genetics Informing Drug Development in Cardiovascular Disease: Interleukin-6 Signaling as a Case Study	6
CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome	6
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy	6
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights From the DCM Consortium	6
Combined RNA Splicing and Patch-Clamp Analysis Reveal Pathogenicity of Splice-Altering Variants in KCNH2 -Related LQTS	6
Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association	6
NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis	6
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older	6
Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases	6
Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy	6
Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion	6
Noncanonical Splice-Altering Variants: Hidden Culprits of Congenital Heart Disease	6
Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults	5
Heritability of Atrial Fibrillation Among Swedish Adoptees	5
Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure	5
Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With de novo Chest Pain	5
Rapidly Progressive Peripheral Artery Disease: Importance of Oligogenic Inheritance and Functional Validation	5
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program	5
Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations	5
Exome Sequencing Enhances Screening for Familial Hypercholesterolemia Within a Multi-Site Healthcare System	5
Screening of ABCG5 and ABCG8 Genes for Sitosterolemia in a Familial Hypercholesterolemia Cascade Screening Program	5
Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort	5
Circulating Branched-Chain Amino Acids, Incident Cardiovascular Disease, and Mortality in the African American Study of Kidney Disease and Hypertension	5
Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study	5
Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome	4
Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study	4
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction	4
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant	4
Prediction of Major Adverse Cardiovascular Events in Patients With Hypertrophic Cardiomyopathy Using Proteomics Profiling	4
High-Risk Nonclassical Long-QT Syndrome Genotypes: Spectrum of Genetic and Phenotypic Features	4
Correction of the Murine Model of Congenital Heart Disease Associated With the Nkx2-5 Mutation Using Prime Editing	4
Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy	4
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations	4
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	3
Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes	3
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	3
Anthropometric Traits and Risk of Mitral Valve Prolapse: A Mendelian Randomization Study	3
Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing	3
Circulating Metabolite Profiles and Risk of Coronary Heart Disease Among Racially and Geographically Diverse Populations	3
The Need for Inclusive Genomic Research	3
Familial Associations of Complete Atrioventricular Block: A National Family Study in Sweden	3
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	3
New Genetic Variant in the MYH7 Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family	3

Drug Target Mendelian Randomization: Distinguishing Between Causal Mechanisms and Biomarkers of Those Mechanisms	3
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	3
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	3
Hypertrophic Cardiomyopathy Secondary to RAF1 Cysteine-Rich Domain Variants	3
Network Preservation Analysis Reveals Dysregulated Metabolic Pathways in Human Vascular Smooth Muscle Cell Phenotypic Switching	3
Crossing the Threshold of Therapeutic Hope for Patients With PKP2 Arrhythmogenic Cardiomyopathy	3
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study	3
Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants	3
Novel Insights Into DMD-Associated Dilated Cardiomyopathy	3
Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3 -Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum	3
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	3
Race, Ancestry, and Disease Outcomes in Black Individuals: a Clarification	3
Dysmorphology-Based Prediction Model for Genetic Disorders in Infants With Congenital Heart Disease	3
Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population	3
Prediction of Positive Genetic Testing for Arrhythmogenic Left Ventricular Cardiomyopathy	3
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research	3
Calmodulinopathies: The Need for a Registry	3