Circulation-Genomic and Precision Medicine

Article	Citations
MYH7 p.Glu903Gln Is a Pathogenic Variant Associated With Hypertrophic Cardiomyopathy	133
Lipoprotein(a) Atherosclerotic Cardiovascular Disease Risk Score Development and Prediction in Primary Prevention From Real-World Data	94
Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course	79
Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults	74
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy	59
Pregnancy Outcomes in Females With Dilated Cardiomyopathy–Associated Rare Genetic Variants	58
Clinical Characteristics of SCN5A p.R965C Carriers: A Common Founder Variant Predisposing to Brugada Syndrome in Thailand	50
How Normal Is Low-Normal Left Ventricular Ejection Fraction in Familial Dilated Cardiomyopathy?	39
Polygenic Risk and Coronary Artery Disease Severity	37
Variant Location Is a Novel Risk Factor for Individuals With Arrhythmogenic Cardiomyopathy Due to a Desmoplakin ( DSP ) Truncating Variant	36
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States	30
Transcription Factors Leave Their Mark on the Heart	28
Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis	27
Mulibrey Nanism and the Real Time Use of Genome and Biobank Engines to Inform Clinical Care in an Ultrarare Disease	27
Hidden Risk: Arrhythmogenic Genes in the General Population	27
Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study	26
Cardioinformatics Advancements in Healthcare and Biotechnology	25
Editorial Board	25
Correction to: Coassin et al, Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk	25
Life by the Numbers	24
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects	23
Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity	22
Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT	22
Recent Advances on the Genetics of Spontaneous Coronary Artery Dissection	22
Molecular Management of Multifocal Atrial Tachycardia in Noonan’s Syndrome With MEK1/2 Inhibitor Trametinib	20

Role of Common Genetic Variation in Lone Atrial Fibrillation	20
Plasma Proteomic Profile Predicts Survival in Heart Failure With Reduced Ejection Fraction	18
Sexual Differences in Genetic Predisposition of Coronary Artery Disease	18
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan	18
Novel SCN5A Variant Shows Multiple Phenotypic Expression in the Same Family	18
Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1–Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome	18
CHDgene: A Curated Database for Congenital Heart Disease Genes	18
Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults	18
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes	17
Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population	17
Life-Time Covariation of Major Cardiovascular Diseases	17
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy	17
Suppression and Replacement Gene Therapy for KCNH2 -Mediated Arrhythmias	17
Identification of a POLG Variant in a Family With Arrhythmogenic Cardiomyopathy and Left Ventricular Fibrosis	17
Rapidly Progressive Peripheral Artery Disease: Importance of Oligogenic Inheritance and Functional Validation	16
Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation	16
Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin	16
Phenotypic Spectrum of Subclinical Sarcomere-Related Hypertrophic Cardiomyopathy and Transition to Overt Disease	16
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias	15
Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank	15
Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy	14
Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopa	14
Heritability of Atrial Fibrillation Among Swedish Adoptees	14
Enhancing the Prediction Power of Polygenic Risk Scores in Genetically Diverse Coronary Heart Disease	14
Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels	13
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	13
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	13
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant	13
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Choleste	13
Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases	12
Impact of Genetic Testing for Cardiomyopathy on Emotional Well-Being and Family Dynamics: A Study of Parents and Adolescents	12
Clinical Outcomes and Genetic Analyses of Restrictive Cardiomyopathy in Children	12
Retraction of: Systematic Evaluation of KCNQ1 variant using ACMG/AMP Guidelines and Risk Stratification in Long QT Syndrome Type 1	12
Exome Sequencing and Congenital Heart Disease in Sub-Saharan Africa	11
High-Risk Nonclassical Long-QT Syndrome Genotypes: Spectrum of Genetic and Phenotypic Features	11
Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K Ca 1.1, in Sinus Node Function and Arrhythmia Risk	11
Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome	11
Clinical Conditions and Their Impact on Utility of Genetic Scores for Prediction of Acute Coronary Syndrome	11
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations	10
Genetically Predicted Lipid Traits, Diabetes Liability, and Carotid Intima-Media Thickness in African Ancestry Individuals: A Mendelian Randomization Study	10
Ultra-Rapid Nanopore Whole Genome Genetic Diagnosis of Dilated Cardiomyopathy in an Adolescent With Cardiogenic Shock	10
Genome-Wide Association and Inheritance-Based Analyses Implicate Unconventional Myosin Genes in Hypoplastic Left Heart Syndrome	10
Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome	10
Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias	10
The Genetic Basis of Primary Cardiomyopathies in Childhood: Implications for Clinical Genetic Testing	10
Cardiomyopathy Genes and Idiopathic VF: A Known Unknown?	10
Communal Coping as a Strategy to Enhance Family Engagement in Dilated Cardiomyopathy	10
Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants	10
Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study	10
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors	10

Splicing Functional Assays Into the Genetic Testing Pipeline	10
Early Childhood-Onset Hypertrophic Cardiomyopathy in a Family With an In-Frame MYH7 Deletion	10
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Rand	9
Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy	9
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy	9
Calmodulinopathy Associated Long QT Syndrome, Hypertrophic Cardiomyopathy With Excessive Trabeculation in a 14-Year-Old Girl Presenting With Ventricular Fibrillation	9
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses	9
Is There a Role for Genetic Testing in Patients With Myocarditis?	9
Coronary Artery Disease Polygenic Risk Score Identifies Patients at Higher Risk for Recurrent Cardiovascular Events in the CANTOS Trial	9
Novel Insights Into DMD-Associated Dilated Cardiomyopathy	9
Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty	9
Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction	9
Genetic Basis of Left Ventricular Noncompaction	9
Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments	9
Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study	9
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies	9
Role of TBX20 Truncating Variants in Dilated Cardiomyopathy and Left Ventricular Noncompaction	8
Polygenic Risk in Families With Dilated Cardiomyopathy	8
Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients With Cardiometabolic Disease	8
Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes	8
Common SYNE2 Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits	8
Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans	8
New Genetic Variant in the MYH7 Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family	8
Development and Implementation of an Integrated Preclinical Atherosclerosis Database	8
Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants	7
DiscoVari : A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes	7
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy	7
Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot	7
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	7
Regional Variation in Cardiovascular Genes Enables a Tractable Genome Editing Strategy	7
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	7
Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants	7
Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture	7
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction	7
Cost-Effectiveness of Polygenic Risk Scores to Guide Statin Therapy for Cardiovascular Disease Prevention	7
Prediction of Major Adverse Cardiovascular Events in Patients With Hypertrophic Cardiomyopathy Using Proteomics Profiling	7
Circulating Blood Plasma Profiling Reveals Proteomic Signature and a Causal Role for SVEP1 in Sudden Cardiac Death	7
Association of Plasma Branched-Chain Amino Acid With Biomarkers of Inflammation and Lipid Metabolism in Women	7
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome	7
Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial	7
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research	6
Prediction of Positive Genetic Testing for Arrhythmogenic Left Ventricular Cardiomyopathy	6
Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction	6
Resource of Gene Expression Data From a Multiethnic Population Cohort of Induced Pluripotent Stem Cell–Derived Cardiomyocytes	6
Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems	6
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	6
Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes	6
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes	6
Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia	6
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	6
Understanding the Complex Genetics of Spontaneous Coronary Artery Dissection: A Guide for Clinicians	6
PLEKHM2 Loss-of-Function Is Associated With Dilated Cardiomyopathy	6
Interpretation of Incidental Genetic Findings Localizing to Genes Associated With Cardiac Channelopathies and Cardiomyopathies	5
Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease	5
Iterative Reanalysis of Hypertrophic Cardiomyopathy Exome Data Reveals Causative Pathogenic Mitochondrial DNA Variants	5
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy	5
Susceptibility Locus for Pregnancy-Associated Spontaneous Coronary Artery Dissection	5
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	5
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study	5
Prediction of Genotype Positivity in Patients With Hypertrophic Cardiomyopathy Using Machine Learning	5
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	5
Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association	5
Genetic Basis of Childhood Cardiomyopathy	5
Clinical Impact of Secondary Risk Factors in TTN -Mediated Dilated Cardiomyopathy	5
Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy	5
Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease	5
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms	5
Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis	5
Using Omics to Identify Novel Therapeutic Targets in Heart Failure	5
Evidence-Based Assessment of Congenital Heart Disease Genes to Enable Returning Results in a Genomic Study	5
Arrhythmogenic Right Ventricular Cardiomyopathy Prevalence and Arrhythmic Outcomes in At-Risk Family Members: A Systematic Review and Meta-Analysis	5
Editors and Editorial Board	5
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	5
AAV-Mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans	4
The Need for Inclusive Genomic Research	4
Presence of the V122I Variant of Hereditary Transthyretin-Mediated Amyloidosis Among Self-Reported White Individuals in a Sponsored Genetic Testing Program	4
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	4
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	4
Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	4
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank	4

Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR	4
Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3 -Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum	4
Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation	4
Genotype-Phenotype Correlation of SCN5A Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands	4
Amino Acid-Level Signal-to-Noise Analysis Aids in Pathogenicity Prediction of Incidentally Identified TTN -Encoded Titin Truncating Variants	4
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	4
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	4
Familial Associations of Complete Atrioventricular Block: A National Family Study in Sweden	4
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	4
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older	4
Correction to: High-Resolution Regulatory Maps Connect Vascular Risk Variants to Disease-Related Pathways	4
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	4
Random Survival Forest Machine Learning for the Prediction of Cardiovascular Events Among Patients With a Measured Lipoprotein(a) Level: A Model Development Study	3
Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population	3
Variant Reinterpretation in Survivors of Cardiac Arrest With Preserved Ejection Fraction (the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry) by Clinicians and Clinical Commercial	3
Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy	3
Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	3
Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems	3
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy	3
Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy	3
Transcriptome Sequencing of Patients With Hypertrophic Cardiomyopathy Reveals Novel Splice-Altering Variants in MYBPC3	3
Value of Genetic Testing for Lipoprotein(a) Variants	3
Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3	3
Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System: Effects and Modifications: A Scientific Statement From the American Heart As	3
Novel Mutation in LOX Associates With a Complex Aneurysmal Vascular and Cardiac Phenotype	3
Genome-Wide Association Study of Peripheral Artery Disease	3
Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults	3
Crossing the Threshold of Therapeutic Hope for Patients With PKP2 Arrhythmogenic Cardiomyopathy	3
Cadherin 2-Related Arrhythmogenic Cardiomyopathy	3
Prevalence and Outcomes of p.Val142Ile TTR Amyloidosis Cardiomyopathy: A Systematic Review	3