Circulation-Genomic and Precision Medicine

Article	Citations
International Evidence Based Reappraisal of Genes Associated With Arrhythmogenic Right Ventricular Cardiomyopathy Using the Clinical Genome Resource Framework	129
Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction	86
Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System: Effects and Modifications: A Scientific Statement From the American Heart As	69
Interactions Between Enhanced Polygenic Risk Scores and Lifestyle for Cardiovascular Disease, Diabetes, and Lipid Levels	66
Genetic Testing for Heritable Cardiovascular Diseases in Pediatric Patients: A Scientific Statement From the American Heart Association	54
How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior: an Observational Follow-up Study	53
Spontaneous Coronary Artery Dissection	47
Associations Between Female Sex, Sarcomere Variants, and Clinical Outcomes in Hypertrophic Cardiomyopathy	44
SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families	43
Genome-Wide Association Study of Peripheral Artery Disease	36
Pathogenic Variants Associated With Dilated Cardiomyopathy Predict Outcome in Pediatric Myocarditis	35
Prevalence and Outcomes of p.Val142Ile TTR Amyloidosis Cardiomyopathy: A Systematic Review	34
Population Bias in Polygenic Risk Prediction Models for Coronary Artery Disease	31
Clinical Profile of Cardiac Involvement in Danon Disease	30
Bayesian Inference Associates Rare KDR Variants With Specific Phenotypes in Pulmonary Arterial Hypertension	30
Genetic Basis of Left Ventricular Noncompaction	27
Considerations for Cardiovascular Genetic and Genomic Research With Marginalized Racial and Ethnic Groups and Indigenous Peoples: A Scientific Statement From the American Heart Association	27
Developing and Optimizing Innovative Tools to Address Familial Hypercholesterolemia Underdiagnosis	27
Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease	26
Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals With Atrial Fibrillation	25
Association of Plasma Branched-Chain Amino Acid With Biomarkers of Inflammation and Lipid Metabolism in Women	25
Genetic Association Between Hypoplastic Left Heart Syndrome and Cardiomyopathies	25
Cadherin 2-Related Arrhythmogenic Cardiomyopathy	24
Sexual Differences in Genetic Predisposition of Coronary Artery Disease	24
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	23

Prevalence and Disease Expression of Pathogenic and Likely Pathogenic Variants Associated With Inherited Cardiomyopathies in the General Population	22
Polygenic Risk Score for Low-Density Lipoprotein Cholesterol Is Associated With Risk of Ischemic Heart Disease and Enriches for Individuals With Familial Hypercholesterolemia	20
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome	20
Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men	20
Transcriptome Sequencing of Patients With Hypertrophic Cardiomyopathy Reveals Novel Splice-Altering Variants in MYBPC3	20
Prevalence of Pathogenic Variants in Cardiomyopathy-Associated Genes in Myocarditis	18
Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K Ca 1.1, in Sinus Node Function and Arrhythmia Risk	18
Exome Sequencing Highlights a Potential Role for Concealed Cardiomyopathies in Youthful Sudden Cardiac Death	18
Exome Sequencing and Congenital Heart Disease in Sub-Saharan Africa	18
Concordance of a High Polygenic Score Among Relatives	18
Genetic Basis of Childhood Cardiomyopathy	18
Recent Advances on the Genetics of Spontaneous Coronary Artery Dissection	18
Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review	17
Comprehensive Investigation of Circulating Biomarkers and Their Causal Role in Atherosclerosis-Related Risk Factors and Clinical Events	17
Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry	17
Predictive Accuracy of a Polygenic Risk Score for Postoperative Atrial Fibrillation After Cardiac Surgery	17
Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes	17
Predictive Accuracy of a Clinical and Genetic Risk Model for Atrial Fibrillation	17
Cost-Effectiveness of Polygenic Risk Scores to Guide Statin Therapy for Cardiovascular Disease Prevention	17
Contribution of Noncanonical Splice Variants to TTN Truncating Variant Cardiomyopathy	16
Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot	16
The Propagation of Racial Disparities in Cardiovascular Genomics Research	16
Integrative Prioritization of Causal Genes for Coronary Artery Disease	16
Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy Through Genomic Screening of Pathogenic or Likely Pathogenic Desmosome Gene Variants	15
Plasma Proteomic Profile Predicts Survival in Heart Failure With Reduced Ejection Fraction	15
Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	14
CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome	14
Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	14
Impact of Genetic Variant Reassessment on the Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy Based on the 2010 Task Force Criteria	14
Genetic Diagnosis and the Severity of Cardiovascular Phenotype in Patients With Elastin Arteriopathy	13
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms	13
Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults	13
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older	13
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Rand	13
Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy	13
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank	13
Evidence-Based Assessment of Congenital Heart Disease Genes to Enable Returning Results in a Genomic Study	12
Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population	12
Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR	12
Promise and Peril of Population Genomics for the Development of Genome-First Approaches in Mendelian Cardiovascular Disease	11
Molecular Management of Multifocal Atrial Tachycardia in Noonan’s Syndrome With MEK1/2 Inhibitor Trametinib	11
Natural History of Hypertrophic Cardiomyopathy in Noonan Syndrome With Multiple Lentigines	11
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	11
Variant Reinterpretation in Survivors of Cardiac Arrest With Preserved Ejection Fraction (the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry) by Clinicians and Clinical Commercial	11
Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation	11
Screening of ABCG5 and ABCG8 Genes for Sitosterolemia in a Familial Hypercholesterolemia Cascade Screening Program	10
Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations	10
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	10
Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants	10
Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults	10

Loss-of-Function FLNC Variants Are Associated With Arrhythmogenic Cardiomyopathy Phenotypes When Identified Through Exome Sequencing of a General Clinical Population	10
Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure	10
Polygenic Risk Score–Enhanced Risk Stratification of Coronary Artery Disease in Patients With Stable Chest Pain	10
Clinical Impact of Secondary Risk Factors in TTN -Mediated Dilated Cardiomyopathy	10
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses	10
Multiomics Screening Identifies Molecular Biomarkers Causally Associated With the Risk of Coronary Artery Disease	10
Novel Mutation in LOX Associates With a Complex Aneurysmal Vascular and Cardiac Phenotype	10
A Pathogenic Variant inALPK3Is Associated With an Autosomal Dominant Adult-onset Hypertrophic Cardiomyopathy	10
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	10
Variant Location Is a Novel Risk Factor for Individuals With Arrhythmogenic Cardiomyopathy Due to a Desmoplakin ( DSP ) Truncating Variant	10
Genetic Susceptibility to Atrial Fibrillation Identified via Deep Learning of 12-Lead Electrocardiograms	10
Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms	9
Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis	9
Novel Gain-of-Function Variant in CACNA1C Associated With Timothy Syndrome, Multiple Accessory Pathways, and Noncompaction Cardiomyopathy	9
Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty	9
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	9
Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure	9
Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome	9
Interpretation of Incidental Genetic Findings Localizing to Genes Associated With Cardiac Channelopathies and Cardiomyopathies	9
Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy	9
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan	9
Importance of Dedicated Units for the Management of Patients With Inherited Arrhythmia Syndromes	9
Clinical Impact of Copy Number Variation on the Genetic Diagnosis of Syndromic Aortopathies	9
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch	9
Prediction of Genotype Positivity in Patients With Hypertrophic Cardiomyopathy Using Machine Learning	9
Genotype-Guided P2Y 12 Inhibitor Therapy After Percutaneous Coronary Intervention: A Bayesian Analysis	8
Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis	8
Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity	8
Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse	8
Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy	8
Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults	8
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Choleste	8
Burden of Cardiomyopathic Genetic Variation in Lethal Pediatric Myocarditis	8
Cardiocutaneous Features of Autosomal Dominant Desmoplakin-Associated Arrhythmogenic Cardiomyopathy	8
CHDgene: A Curated Database for Congenital Heart Disease Genes	8
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes	7
Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications	7
KCNQ1 and Long QT Syndrome in 1/45 Amish	7
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and	7
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	7
Genotype-Phenotype Correlation of SCN5A Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands	7
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	7
Life-Time Covariation of Major Cardiovascular Diseases	7
Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort: The Use of Genetic Testing in Risk Stratification	7
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	7
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	7
Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients With Cardiometabolic Disease	7
Suppression and Replacement Gene Therapy for KCNH2 -Mediated Arrhythmias	7
Human-Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for TNNT2 Δ160E-Induced Cardiomyopathy	7
Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion	7
Amino Acid-Level Signal-to-Noise Analysis Aids in Pathogenicity Prediction of Incidentally Identified TTN -Encoded Titin Truncating Variants	7
Cardiac Sarcoidosis Mimickers: Genetic Testing in Undifferentiated Inflammatory Cardiomyopathies	6
Truncating Variants in OBSCN Gene Associated With Disease-Onset and Outcomes of Hypertrophic Cardiomyopathy	6
Is There a Role for Genetic Testing in Patients With Myocarditis?	6
Role of Common Genetic Variation in Lone Atrial Fibrillation	6
Efficacy and Safety of ARRY-371797 in LMNA -Related Dilated Cardiomyopathy: A Phase 2 Study	6
Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation	6
Familial Recurrence Patterns in Congenitally Corrected Transposition of the Great Arteries: An International Study	6
Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank	6
Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT	6
Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib	6
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy	6
Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture	6
Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1–Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome	6
Monoallelic Mutations in CC2D1A Suggest a Novel Role in Human Heterotaxy and Ciliary Dysfunction	5
Arrhythmogenic Right Ventricular Cardiomyopathy Prevalence and Arrhythmic Outcomes in At-Risk Family Members: A Systematic Review and Meta-Analysis	5
Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction	5
Genetic Dilated Cardiomyopathy Due to TTN Variants Without Known Familial Disease	5
Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics	5
Thrombotic Risk Determined by STAB 2 Variants in a Population-Based Cohort Study	5
Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment	5
Genetic Testing in Patients With Congenital Heart Disease: You Do No Harm When Using the Right Tools!	5
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	5
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	5
Identification of a POLG Variant in a Family With Arrhythmogenic Cardiomyopathy and Left Ventricular Fibrosis	5
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease	5
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program	5
Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease	5
Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk	5
Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease	5

Susceptibility Locus for Pregnancy-Associated Spontaneous Coronary Artery Dissection	5
Serum Albumin and Incident Heart Failure	5
Novel SCN5A Variant Shows Multiple Phenotypic Expression in the Same Family	5
Features of Vascular Ehlers-Danlos Syndrome Among Biobank Participants Harboring Predicted High-Risk COL3A1 Genotypes	5
Metabolomic Effects of Hormone Therapy and Associations With Coronary Heart Disease Among Postmenopausal Women	5
Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization	5
Impact of a Population Genomic Screening Program on Health Behaviors Related to Familial Hypercholesterolemia Risk Reduction	5
Presence of the V122I Variant of Hereditary Transthyretin-Mediated Amyloidosis Among Self-Reported White Individuals in a Sponsored Genetic Testing Program	4
PLEKHM2 Loss-of-Function Is Associated With Dilated Cardiomyopathy	4
Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial	4
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	4
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial	4
MYH7 p.Glu903Gln Is a Pathogenic Variant Associated With Hypertrophic Cardiomyopathy	4
Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies	4
Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3	4
AAV-Mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans	4
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	4
Clinical Outcomes and Genetic Analyses of Restrictive Cardiomyopathy in Children	4
Associations Between Alcohol Intake and Genetic Predisposition With Atrial Fibrillation Risk in a National Biobank	4
Phenotypic Characterization of Timothy Syndrome Caused by the CACNA1C p.Gly402Ser Variant	4
Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing	4
Prevalence and Phenotypic Correlations of Calmodulinopathy-Causative CALM1-3 Variants Detected in a Multicenter Molecular Autopsy Cohort of Sudden Unexplained Death Vict	4
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus	4
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	4
Clinical Conditions and Their Impact on Utility of Genetic Scores for Prediction of Acute Coronary Syndrome	4
Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias	4
Clinical Characteristics of SCN5A p.R965C Carriers: A Common Founder Variant Predisposing to Brugada Syndrome in Thailand	4
Persistent Troponin Elevation in Left-Dominant Arrhythmogenic Cardiomyopathy	4
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	4