OOIR: Observatory of International Research

Papers

(The TQCC of CRISPR Journal is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	51
Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions	39
Will Advances in Genetic Medicine Lessen the Need for Germline Modifications?	37
Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	36
Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types	33
Subtypes of Type I-E CRISPR-Cas Systems Distribution in Human Escherichia coli Isolates from China	31
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	31
Hairpin Internal Nuclear Localization Signals in CRISPR-Cas9 Enhance Editing in Primary Human Lymphocytes	30
Gene Editing and Rett Syndrome: Does It Make the Cut?	24
Acknowledgment of Reviewers 2022	23
Opposing Human Genetic Engineering	21
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	19
The Lexicon of CRISPR: When Is It Too Much?	19
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	18
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	17
Curing “GFP-itis” in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students	17
Efficient Installation of Heterozygous Mutations in Human Pluripotent Stem Cells Using Prime Editing	15
Early Detection of Wildlife Disease Pathogens Using CRISPR-Cas System Methods	15
The Roles and Responsibilities of Scientific Journals in Research Governance: Editorial Policymaking at Nature and Springer Nature (1995–2023)	14
Viability-Based Assessment Reveals True Efficiency of CRISPR-Cas9 Transfection Methods in Rabbit Spermatozoa	14
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing	14
CRISPR Crops and Sustainable Agriculture	14
Regulatory Support for CRISPR in Ag: A Timely EU-Turn	13
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	13
CRISPR-Cas9 Single Nucleotide Editing of Tuberous Sclerosis Complex 2 Gene in Mesenchymal Stem Cells	13

Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	13
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	12
Engineering CjCas9 for Efficient Base Editing and Prime Editing	12
Institutional Bioethics: From Critical Interdisciplinarity to Cosmopolitanism	12
A Story of Perseverance: An Interview with Matthew Porteus	12
Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR	12
Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes	12
dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer	12
Fanzors: Mysterious TnpB-Like Bacterial Transposon-Related RNA-Guided DNA Nucleases of Eukaryotes	11
CRISPR Momentum in the Clinic and the Field	11
Engineered Antiviral Sensor Targets Infected Mosquitoes	11
Efficient CRISPR-Cas9-Mediated Genome Editing of the Cane Toad ( Rhinella marina )	11
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	11
Enhancements of the CRISPR-Cas System in the Silkworm Bombyx mori	11
A PCR-Induced Mutagenesis-Restriction Fragment Length Polymorphism Method for the Detection of CRISPR-Induced Indels	10
Affordable Pricing of CRISPR Treatments is a Pressing Ethical Imperative	10
Conditional Expression of Cas9 and dCas9 in Lucilia cuprina Reveals dCas9-Associated Lethality	10
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	10
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors	10
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	9
Introducing Faith-Based Claims to Ethical Discourse on Scientific Matters	9
CRISPR-Cas9-Mediated Correction of TSC2 Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2	9
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	9
A Protein-Cutting CRISPR Complex Caught in Action	9
Are We Making Genetically Modified Humans?	9
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13	9
Cas12a-Capture: A Novel, Low-Cost, and Scalable Method for Targeted Sequencing	9
Navigating Viral Space with CRISPR Technologies	9
Five Years of Progress in CRISPR Clinical Trials (2019–2024)	8
Rapid Variant Pathogenicity Analysis by CRISPR Activation of CRB1 Gene Expression in Patient-Derived Fibroblasts	8
CRISPR Medicine Needs Infrastructure, Not Just Innovation	8
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects	8
Acknowledgment of Reviewers 2023	8
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells	7
Strategies for Interdisciplinary Human Gene Editing Research: Insights from a Swiss Project	7
Genome Editing Headwinds: Can CRISPR Stay on Target?	7
The New Old Colonialism	7
An Optimized Workflow for In Vitro Transcription of Single Guide RNAs Minimizes Innate Immune Activation	7
Moving Therapeutic Genome Editing into Global Clinical Trials and Medicine	7