OOIR: Observatory of International Research

Papers

(The TQCC of CRISPR Journal is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Inference of CRISPR Edits from Sanger Trace Data	224
CRISPRCasTyper: Automated Identification, Annotation, and Classification of CRISPR-Cas Loci	125
Programmable RNA Targeting Using CasRx in Flies	60
CRISPR-Cas9-Based Genome Editing in the Silverleaf Whitefly (Bemisia tabaci)	58
Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data	55
Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation	55
Human Germline and Heritable Genome Editing: The Global Policy Landscape	54
ErCas12a CRISPR-MAD7 for Model Generation in Human Cells, Mice, and Rats	33
CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes	33
Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods	33
Detection and Modulation of DNA Translocations During Multi-Gene Genome Editing in T Cells	32
Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors	31
CRISPR-Cas12a Genome Editing at the Whole-Plant Level Using Two Compatible RNA Virus Vectors	30
ON-Target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected	29
Progress Toward Zygotic and Germline Gene Drives in Mice	27
Sensitive and Easy-Read CRISPR Strip for COVID-19 Rapid Point-of-Care Testing	25
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	25
CRISPR-Cas9-Mediated Gene Editing of MYB28 Genes Impair Glucoraphanin Accumulation of Brassica oleracea in the Field	24
Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella	24
Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities	24
A Code of Ethics for Gene Drive Research	23
Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia	21
Bacterial Retrons Enable Precise Gene Editing in Human Cells	21
Targeted RNA Knockdown by a Type III CRISPR-Cas Complex in Zebrafish	20
Genome Editing Using the CRISPR-Cas9 System to Generate a Solid-Red Germline of Nile Tilapia (Oreochromis niloticus)	19

Translating CRISPR-Cas Therapeutics: Approaches and Challenges	19
Characterization of SHATTERPROOF Homoeologs and CRISPR-Cas9-Mediated Genome Editing Enhances Pod-Shattering Resistance in Brassica napus L.	19
CRISPR-Assisted DNA Detection: A Novel dCas9-Based DNA Detection Technique	19
Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia	18
Unprecedented Diversity of Unique CRISPR-Cas-Related Systems and Cas1 Homologs in Asgard Archaea	18
CRISPR Arrays Away from cas Genes	17
CRISPR-Cas “Non-Target” Sites Inhibit On-Target Cutting Rates	17
Heritable Human Genome Editing: The Public Engagement Imperative	17
High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells	17
What Do We (Not) Know About Global Views of Human Gene Editing? Insights and Blind Spots in the CRISPR Era	16
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	16
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing	14
Reactions to the National Academies/Royal Society Report onHeritable Human Genome Editing	14
Recent Advances in CRISPR-Based Biosensors for Point-of-Care Pathogen Detection	14
Programming Cells by Multicopy Chromosomal Integration Using CRISPR-Associated Transposases	13
One-Step Homology Mediated CRISPR-Cas Editing in Zygotes for Generating Genome Edited Cattle	13
CRISPRclassify: Repeat-Based Classification of CRISPR Loci	13
CRISPR-Mediated Synergistic Epigenetic and Transcriptional Control	13
Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing	13
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	13
Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease	13
(Broken) Promises of Sustainable Food and Agriculture through New Biotechnologies: The CRISPR Case	12
Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination	12
Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics	12
Temperature-Inducible Precision-Guided Sterile Insect Technique	12
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	12
Catalytically Enhanced Cas9 Through Directed Protein Evolution	11
Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase–nCas9 Fusions	11
Development of a Cas12a-Based Genome Editing Tool for Moderate Thermophiles	10
A Novel Set of Cas9 Fusion Proteins to Stimulate Homologous Recombination: Cas9-HRs	10
Genetically Encoded CRISPR Components Yield Efficient Gene Editing in the Invasive Pest Drosophila suzukii	10
Increased Efficiency for Biallelic Mutations of theCCR5Gene by CRISPR-Cas9 Using Multiple Guide RNAs As a Novel Therapeutic Option for Human Immunodeficiency Virus	10
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	10
The Cas9 Hammer—and Sickle: A Challenge for Genome Editors	10
Low-Density Lipoprotein Receptor–Related Protein 5–Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature	10
Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing	9
Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration	9
Open Sharing During COVID-19: CRISPR-Based Detection Tools	9
A Tandem Guide RNA-Based Strategy for Efficient CRISPR Gene Editing of Cell Populations with Low Heterogeneity of Edited Alleles	9
Reproducible Antigen Recognition by the Type I-F CRISPR-Cas System	9
Improving FnCas12a Genome Editing by Exonuclease Fusion	9
The Transposon-Encoded Protein TnpB Processes Its Own mRNA into ωRNA for Guided Nuclease Activity	9
A Living Organism in your CRISPR Toolbox: Caenorhabditis elegans Is a Rapid and Efficient Model for Developing CRISPR-Cas Technologies	9
The DNA-Dialogue: A Broad Societal Dialogue About Human Germline Genome Editing in the Netherlands	9
Development and Characterization of a Modular CRISPR and RNA Aptamer Mediated Base Editing System	9
RNA Binding Proteins As Regulators of Oxidative Stress Identified by a Targeted CRISPR-Cas9 Single Guide RNA Library	8
A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation	8
New Editing Tools for Gene Therapy in Inherited Retinal Dystrophies	8
Regulatory Considerations for Clinical Trial Applications with CRISPR-Based Medicinal Products	8
New Additions to the CRISPR Toolbox: CRISPR-CLONInG and CRISPR-CLIP for Donor Construction in Genome Editing	8

Application of CRISPR-Cas9 Editing for Virus Engineering and the Development of Recombinant Viral Vaccines	8
Promoter Orientation within an AAV-CRISPR Vector Affects Cas9 Expression and Gene Editing Efficiency	8
CRISPR-Cas9-Mediated Intersectional Knockout of Glycogen Synthase Kinase 3β in D2 Receptor–Expressing Medial Prefrontal Cortex Neurons Reveals Contributions to Emotional Regulation	8
CALITAS: A CRISPR-Cas-aware ALigner for In silico off-TArget Search	8
A Mutation-Agnostic Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy	8
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	8
AsCRISPR: A Web Server for Allele-Specific Single Guide RNA Design in Precision Medicine	8
Cas4–Cas1 Is a Protospacer Adjacent Motif–Processing Factor Mediating Half-Site Spacer Integration During CRISPR Adaptation	8
Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells	8
Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing	8
Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence	8