CRISPR Journal

Article	Citations
Inference of CRISPR Edits from Sanger Trace Data	224
CRISPRCasTyper: Automated Identification, Annotation, and Classification of CRISPR-Cas Loci	125
Programmable RNA Targeting Using CasRx in Flies	60
CRISPR-Cas9-Based Genome Editing in the Silverleaf Whitefly (Bemisia tabaci)	58
Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data	55
Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation	55
Human Germline and Heritable Genome Editing: The Global Policy Landscape	54
Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods	33
ErCas12a CRISPR-MAD7 for Model Generation in Human Cells, Mice, and Rats	33
CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes	33
Detection and Modulation of DNA Translocations During Multi-Gene Genome Editing in T Cells	32
Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors	31
CRISPR-Cas12a Genome Editing at the Whole-Plant Level Using Two Compatible RNA Virus Vectors	30
ON-Target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected	29
Progress Toward Zygotic and Germline Gene Drives in Mice	27
Sensitive and Easy-Read CRISPR Strip for COVID-19 Rapid Point-of-Care Testing	25
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	25
CRISPR-Cas9-Mediated Gene Editing of MYB28 Genes Impair Glucoraphanin Accumulation of Brassica oleracea in the Field	24
Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella	24
Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities	24
A Code of Ethics for Gene Drive Research	23
Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia	21
Bacterial Retrons Enable Precise Gene Editing in Human Cells	21
Targeted RNA Knockdown by a Type III CRISPR-Cas Complex in Zebrafish	20
Genome Editing Using the CRISPR-Cas9 System to Generate a Solid-Red Germline of Nile Tilapia (Oreochromis niloticus)	19

Translating CRISPR-Cas Therapeutics: Approaches and Challenges	19
Characterization of SHATTERPROOF Homoeologs and CRISPR-Cas9-Mediated Genome Editing Enhances Pod-Shattering Resistance in Brassica napus L.	19
CRISPR-Assisted DNA Detection: A Novel dCas9-Based DNA Detection Technique	19
Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia	18
Unprecedented Diversity of Unique CRISPR-Cas-Related Systems and Cas1 Homologs in Asgard Archaea	18
CRISPR Arrays Away from cas Genes	17
CRISPR-Cas “Non-Target” Sites Inhibit On-Target Cutting Rates	17
Heritable Human Genome Editing: The Public Engagement Imperative	17
High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells	17
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	16
What Do We (Not) Know About Global Views of Human Gene Editing? Insights and Blind Spots in the CRISPR Era	16
Recent Advances in CRISPR-Based Biosensors for Point-of-Care Pathogen Detection	14
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing	14
Reactions to the National Academies/Royal Society Report onHeritable Human Genome Editing	14
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	13
Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease	13
Programming Cells by Multicopy Chromosomal Integration Using CRISPR-Associated Transposases	13
One-Step Homology Mediated CRISPR-Cas Editing in Zygotes for Generating Genome Edited Cattle	13
CRISPRclassify: Repeat-Based Classification of CRISPR Loci	13
CRISPR-Mediated Synergistic Epigenetic and Transcriptional Control	13
Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing	13
(Broken) Promises of Sustainable Food and Agriculture through New Biotechnologies: The CRISPR Case	12
Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination	12
Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics	12
Temperature-Inducible Precision-Guided Sterile Insect Technique	12
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	12
Catalytically Enhanced Cas9 Through Directed Protein Evolution	11
Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase–nCas9 Fusions	11
Development of a Cas12a-Based Genome Editing Tool for Moderate Thermophiles	10
A Novel Set of Cas9 Fusion Proteins to Stimulate Homologous Recombination: Cas9-HRs	10
Genetically Encoded CRISPR Components Yield Efficient Gene Editing in the Invasive Pest Drosophila suzukii	10
Increased Efficiency for Biallelic Mutations of theCCR5Gene by CRISPR-Cas9 Using Multiple Guide RNAs As a Novel Therapeutic Option for Human Immunodeficiency Virus	10
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	10
The Cas9 Hammer—and Sickle: A Challenge for Genome Editors	10
Low-Density Lipoprotein Receptor–Related Protein 5–Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature	10
Development and Characterization of a Modular CRISPR and RNA Aptamer Mediated Base Editing System	9
Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing	9
Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration	9
Open Sharing During COVID-19: CRISPR-Based Detection Tools	9
A Tandem Guide RNA-Based Strategy for Efficient CRISPR Gene Editing of Cell Populations with Low Heterogeneity of Edited Alleles	9
Reproducible Antigen Recognition by the Type I-F CRISPR-Cas System	9
Improving FnCas12a Genome Editing by Exonuclease Fusion	9
The Transposon-Encoded Protein TnpB Processes Its Own mRNA into ωRNA for Guided Nuclease Activity	9
A Living Organism in your CRISPR Toolbox: Caenorhabditis elegans Is a Rapid and Efficient Model for Developing CRISPR-Cas Technologies	9
The DNA-Dialogue: A Broad Societal Dialogue About Human Germline Genome Editing in the Netherlands	9
Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells	8
Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing	8
Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence	8
RNA Binding Proteins As Regulators of Oxidative Stress Identified by a Targeted CRISPR-Cas9 Single Guide RNA Library	8
A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation	8

New Editing Tools for Gene Therapy in Inherited Retinal Dystrophies	8
Regulatory Considerations for Clinical Trial Applications with CRISPR-Based Medicinal Products	8
New Additions to the CRISPR Toolbox: CRISPR-CLONInG and CRISPR-CLIP for Donor Construction in Genome Editing	8
Application of CRISPR-Cas9 Editing for Virus Engineering and the Development of Recombinant Viral Vaccines	8
Promoter Orientation within an AAV-CRISPR Vector Affects Cas9 Expression and Gene Editing Efficiency	8
CRISPR-Cas9-Mediated Intersectional Knockout of Glycogen Synthase Kinase 3β in D2 Receptor–Expressing Medial Prefrontal Cortex Neurons Reveals Contributions to Emotional Regulation	8
CALITAS: A CRISPR-Cas-aware ALigner for In silico off-TArget Search	8
A Mutation-Agnostic Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy	8
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	8
AsCRISPR: A Web Server for Allele-Specific Single Guide RNA Design in Precision Medicine	8
Cas4–Cas1 Is a Protospacer Adjacent Motif–Processing Factor Mediating Half-Site Spacer Integration During CRISPR Adaptation	8
A Meta-Analysis of gRNA Library Screens Enables an Improved Understanding of the Impact of gRNA Folding and Structural Stability on CRISPR-Cas9 Activity	7
Strategies for Enhancing the Homology-Directed Repair Efficiency of CRISPR-Cas Systems	7
Regulation of Gene Expression and the Elucidative Role of CRISPR-Based Epigenetic Modifiers and CRISPR-Induced Chromosome Conformational Changes	7
Dead Cas9–sgRNA Complex Shelters Vulnerable DNA Restriction Enzyme Sites from Cleavage for Cloning Applications	7
Novel Type V-A CRISPR Effectors Are Active Nucleases with Expanded Targeting Capabilities	7
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes	6
Ethics and Global Governance of Human Germline Genome Editing: The Problem of Techno-Scientific Colonialist Paternalism	6
Multiplex Gene Tagging with CRISPR-Cas9 for Live-Cell Microscopy and Application to Study the Role of SARS-CoV-2 Proteins in Autophagy, Mitochondrial Dynamics, and Cell Growth	6
On- and Off-Target Analyses of CRISPR-Cas12b Genome Editing Systems in Rice	6
Fast and Efficient Generation of Isogenic Induced Pluripotent Stem Cell Lines Using Adenine Base Editing	6
A Flexible, Pooled CRISPR Library for Drug Development Screens	6
CRISPRa-Mediated Upregulation of scn1laa During Early Development Causes Epileptiform Activity and dCas9-Associated Toxicity	6
Evaluation of Gene Knockouts by CRISPR as Potential Targets for the Genetic Engineering of the Mosquito Culex quinquefasciatus	6
A CRISPR-Cas9, Cre-lox, and Flp-FRT Cascade Strategy for the Precise and Efficient Integration of Exogenous DNA into Cellular Genomes	6
Natural Nucleoside Modifications in Guide RNAs Can Modulate the Activity of the CRISPR-Cas9 System In Vitro	6
Advances in CRISPR Delivery Methods: Perspectives and Challenges	6
RNA-Responsive gRNAs for Controlling CRISPR Activity: Current Advances, Future Directions, and Potential Applications	5
Multiplex Editing of the Nucleoredoxin1 Tandem Array in Poplar: From Small Indels to Translocations and Complex Inversions	5
The View from the Benches: Scientists' Perspectives on the Uses and Governance of Human Gene-Editing Research	5
Allele-Specific Inactivation of an Autosomal Dominant Epidermolysis Bullosa Simplex Mutation Using CRISPR-Cas9	5
Immaculate Conception? Priority and Invention in the CRISPR Patent Dispute	5
Retrons: Complementing CRISPR in Phage Defense	5
Identification and Evolution of Cas9 tracrRNAs	5
Deep Sequencing Reveals the Comprehensive CRISPR-Cas9 Editing Spectrum in Bombyx mori	5
A Decade of CRISPR Gene Editing in China and Beyond: A Scientometric Landscape	5
Diversification of the CRISPR Toolbox: Applications of CRISPR-Cas Systems Beyond Genome Editing	5
Sharing the CRISPR Toolbox with an Expanding Community	5
Universal Gene Correction Approaches for β-hemoglobinopathies Using CRISPR-Cas9 and Adeno-Associated Virus Serotype 6 Donor Templates	5
Finding SECURE Ground: USDA Edits the Biotechnology Regulatory Framework	4
Functional Characterization of Type III-A CRISPR-Cas in a Clinical Human Methicillin-R Staphylococcus aureus Strain	4
Functional Study of the Type II-A CRISPR-Cas System of Streptococcus agalactiae Hypervirulent Strains	4
gEL DNA: A Cloning- and Polymerase Chain Reaction–Free Method for CRISPR-Based Multiplexed Genome Editing	4
CRISPR Hits Home in a First-in-Human Study	4
Locus-Specific Genomic DNA Purification Using the CRISPR System: Methods and Applications	4
Site-Specific Labeling Reveals Cas9 Induces Partial Unwinding Without RNA/DNA Pairing in Sequences Distal to the PAM	4
Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors	4
Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity	4
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	4
Miniature CRISPR-Cas12f1-Mediated Single-Nucleotide Microbial Genome Editing Using 3′-Truncated sgRNA	4
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells	4
Optimized Guide RNA Selection Improves Streptococcus pyogenes Cas9 Gene Editing of Human Hematopoietic Stem and Progenitor Cells	4
Efficient and Fast Generation of Relevant Disease Mouse Models by In Vitro and In Vivo Gene Editing of Zygotes	4
Enhanced Taq Variant Enables Efficient Genome Editing Testing and Mutation Detection	4
The CRISPR Patent Landscape: Focus on Chinese Researchers	4
CRISPR-Cas13 as an Antiviral Strategy for Coronavirus Disease 2019	4
GeneTargeter: Automated In Silico Design for Genome Editing in the Malaria Parasite, Plasmodium falciparum	3
Engineered Antiviral Sensor Targets Infected Mosquitoes	3
The Art of Being Single	3
Determination of Factors Driving the Genome Editing Field in the CRISPR Era Using Bibliometrics	3
Gene-Edited Fluorescent and Mixed Cerebral Organoids	3
Pseudogene-Mediated Gene Conversion After CRISPR-Cas9 Editing Demonstrated by Partial CD33 Conversion with SIGLEC22P	3
GOANA: A Universal High-Throughput Web Service for Assessing and Comparing the Outcome and Efficiency of Genome Editing Experiments	3
Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic	3
CRISPR-Associated Transposase System Can Insert Multiple Copies of Donor DNA into the Same Target Locus	3
CRISPR-Cas9 Technology as a Tool to Target Gene Drivers in Cancer: Proof of Concept and New Opportunities to Treat Chronic Myeloid Leukemia	3
CASPER: An Integrated Software Platform for Rapid Development of CRISPR Tools	3
Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins	3
Nobel Dreams Come True for Doudna and Charpentier	3
Functional and Phylogenetic Diversity of Cas10 Proteins	3
CRISPR and Long-Read Sequencing: A Perfect Match	3
Multiplex gRNAs Synergically Enhance Detection of SARS-CoV-2 by CRISPR-Cas12a	3
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies	3
Base Editing of Somatic Cells Using CRISPR–Cas9 in Drosophila	3
Induction and Elimination of Prophages Using CRISPR Interference	3
In Vitro Validation of Transgene Expression in Gene-Edited Pigs Using CRISPR Transcriptional Activators	3
Vulnerability and the Ethics of Human Germline Genome Editing	2
Prime Editing: Making the Move to Prime Time	2
In Vitro CRISPR-Cas12a-Based Detection of Cancer-Associated TP53 Hotspot Mutations Beyond the crRNA Seed Region	2
Search for Origins of Anti-CRISPR Proteins by Structure Comparison	2

Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	2
PASTE: The Way Forward for Large DNA Insertions	2
A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs	2
A Novel System for Simple Rapid Adenoviral Vector Construction to Facilitate CRISPR/Cas9-Mediated Genome Editing	2
Impact of KIT Editing on Coat Pigmentation and Fresh Meat Color in Yorkshire Pigs	2
Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes	2
Rapid Whole-Genome Identification of High Quality CRISPR Guide RNAs with the Crackling Method	2
Expression of Cas9 in a Syngeneic Model of Primary Central Nervous System Lymphoma Induces Intracerebral NK and CD8 T Cell-Mediated Lymphoma Cell Lysis Via Perforin	2
The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells	2
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	2
Can Deep Learning Solve the Cas9 Dilemma?	2
Expanding the Toolkit for Genome Editing in a Disease Vector, Aedes aegypti: Transgenic Lines Expressing Cas9 and Single Guide RNA Induce Efficient Mutagenesis	2
SuperFi-Cas9: High Fidelity Meets High Activity	2
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	2
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences	2
Self-Cutting and Integrating CRISPR Plasmids Enable Targeted Genomic Integration of Genetic Payloads for Rapid Cell Engineering	2
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	2
A Cellular Stress Response Induced by the CRISPR-dCas9 Activation System Is Not Heritable Through Cell Divisions	2
A CRISPR-dCas9 System for Assaying and Selecting for RNase III Activity In Vivo in Escherichia coli	2
Periodontal Disease Pathogens, Pathogenesis, and Therapeutics: The CRISPR-Cas Effect	2
Optimization of Genomewide CRISPR Screens Using AsCas12a and Multi-Guide Arrays	2
Transversion Expansion of Base Editing	2
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome	2
Replication Protein Rep Provides Selective Advantage to Viruses in the Presence of CRISPR-Cas Immunity	2
Assessing Off-Target Editing of CRISPR-Cas9 Systems	2
The CRISPR-RNA World: An Interview with Martin Jínek	2