OOIR: Observatory of International Research

Papers

(The median citation count of CRISPR Journal is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	534
Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions	54
Hairpin Internal Nuclear Localization Signals in CRISPR-Cas9 Enhance Editing in Primary Human Lymphocytes	53
Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	45
Will Advances in Genetic Medicine Lessen the Need for Germline Modifications?	43
Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types	43
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	43
Inference of CRISPR Edits from Sanger Trace Data	35
A Taxonomic and Phylogenetic Classification of Diverse Base Editors	34
Acknowledgment of Reviewers 2022	34
Opposing Human Genetic Engineering	33
Curing “GFP-itis” in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students	30
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	30
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	29
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	27
The Lexicon of CRISPR: When Is It Too Much?	26
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	24
Efficient Installation of Heterozygous Mutations in Human Pluripotent Stem Cells Using Prime Editing	24
Gene Editing and Rett Syndrome: Does It Make the Cut?	24
Early Detection of Wildlife Disease Pathogens Using CRISPR-Cas System Methods	22
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing	21
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	20
Implementing CRISPR-Cas9 Yeast Practicals into Biology Curricula	19
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	18
CRISPR Crops and Sustainable Agriculture	17

The Roles and Responsibilities of Scientific Journals in Research Governance: Editorial Policymaking at Nature and Springer Nature (1995–2023)	17
CRISPR-Cas9 Single Nucleotide Editing of Tuberous Sclerosis Complex 2 Gene in Mesenchymal Stem Cells	16
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	16
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	16
dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer	15
A Story of Perseverance: An Interview with Matthew Porteus	14
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	14
Institutional Bioethics: From Critical Interdisciplinarity to Cosmopolitanism	14
Engineered Antiviral Sensor Targets Infected Mosquitoes	13
Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes	13
Engineering CjCas9 for Efficient Base Editing and Prime Editing	13
CRISPR à la carte	12
CRISPR Rewrites the Future of Medicine	12
Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors	12
Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR	12
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	12
Fanzors: Mysterious TnpB-Like Bacterial Transposon-Related RNA-Guided DNA Nucleases of Eukaryotes	11
Efficient CRISPR-Cas9-Mediated Genome Editing of the Cane Toad ( Rhinella marina )	11
Affordable Pricing of CRISPR Treatments is a Pressing Ethical Imperative	11
Enhancements of the CRISPR-Cas System in the Silkworm Bombyx mori	11
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors	10
A PCR-Induced Mutagenesis-Restriction Fragment Length Polymorphism Method for the Detection of CRISPR-Induced Indels	10
CRISPR Momentum in the Clinic and the Field	10
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	10
Acknowledgment of Reviewers 2023	9
Cas12a-Capture: A Novel, Low-Cost, and Scalable Method for Targeted Sequencing	9
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	9
CRISPR-Cas9-Mediated Correction of TSC2 Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2	9
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects	9
Bacterial Retrons Enable Precise Gene Editing in Human Cells	9
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13	9
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	9
Navigating Viral Space with CRISPR Technologies	9
A Protein-Cutting CRISPR Complex Caught in Action	9
Introducing Faith-Based Claims to Ethical Discourse on Scientific Matters	9
It's a Knockout for Cat Allergies?	9
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	8
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells	8
Five Years of Progress in CRISPR Clinical Trials (2019–2024)	8
Moving Therapeutic Genome Editing into Global Clinical Trials and Medicine	8
Rapid Variant Pathogenicity Analysis by CRISPR Activation of CRB1 Gene Expression in Patient-Derived Fibroblasts	8
The New Old Colonialism	8
Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity	7
Special Issue : Manipulating the Microbiome with CRISPR	7
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	7
Characterization of Research Support of Genome Editing Technologies and Transition to Clinical Trials	7
Correction to: APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels by Rieffer et al. The CRISPR Journal	7
Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities	7
Genome Editing Headwinds: Can CRISPR Stay on Target?	7
Correction to: Give Cas a Chance: An Actionable Path to a Platform for CRISPR Cures , by Fyodor D. Urnov [DOI: 10.1089/crispr.2024.0082]	6

Extreme Genome Editing	6
Special Issue : CRISPR Trials	6
Novel off-Targeting Events Identified after Genome Wide Analysis of CRISPR-Cas Edited Pigs	6
Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic	6
Recalibrating Health Governance, Equity, and Reproductive Rights in India: A Case Study from the Global South	6
A Reset for Bioethics: A Statement from the Global Observatory for Genome Editing	6
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes	5
CRISPR-Cas9-Mediated Targeting of Multidrug Resistance Genes in Methicillin-Resistant Staphylococcus aureus	5
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome	5
Introducing Perspectives from the Global Observatory for Genome Editing	5
BAR-CAT: Targeted Recovery of Synthetic Genes via Barcode-Directed CRISPR-dCas9 Enrichment	5
PASTE: The Way Forward for Large DNA Insertions	5
Celebrating a Decade of CRISPR-Fueled Genome Editing	5
A Phage Variable Region Encodes Anti-CRISPR Proteins Inhibiting All Streptococcus thermophilus CRISPR Immune Systems	5
Facing Systemic Uncertainty, Can the CRISPR Community Stay the Course?	5
Cosmopolitan Bioethics Under Pressure: Reflections on the Global Observatory for Genome Editing International Summit	5
An Efficient and Cost-Effective Novel Strategy for Identifying CRISPR-Cas-Mediated Mutants in Plant Offspring	5
Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing	5
Modified Cas9-Guided Oxford Nanopore Technology Sequencing Uncovers Single and Multiple Transgene Insertion Sites in a Zebrafish Melanoma Model	5
Optimization of Genomewide CRISPR Screens Using AsCas12a and Multi-Guide Arrays	4
APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels	4
Science with Society at Science Gallery Bengaluru	4
Toward a Global Deliberative System for Genome Editing	4
Green Fluorescent Protein Tagged Polycistronic Reporter System Reveals Functional Editing Characteristics of CRISPR-Cas	4
High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells	4
Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability	4
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa	4
Predicting Mutations Generated by Cas9, Base Editing, and Prime Editing in Mammalian Cells	4
Correction to: Genotyping MUltiplexed-Sequencing of CRISPR-Localized Editing (GMUSCLE): An Experimental and Computational Approach for Analyzing CRISPR-Edited Cells	4
Viral Delivery of Compact CRISPR-Cas12f for Gene Editing Applications	4
Genetic Manipulation of a CAST of Characters in a Microbial Community	4
Response to Cook et al. re: Novel Off-Targeting Events Identified After Genome Wide Analysis of CRISPR-Cas Edited Pig	4
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences	4
A “Bare Hope of A Result”: The Second CRISPR Patent Appeal	3
Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of a dCas9 Ribonucleoprotein Complex	3
AI and SynBio Meet CRISPR Heralding a New Genome Editing Era	3
Genome Editing in Apicomplexan Parasites: Current Status, Challenges, and Future Possibilities	3
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies	3
Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors	3
Highly Efficient One-Step Tagging of Endogenous Genes in Primary Cells Using CRISPR-Cas Ribonucleoproteins	3
Modulating CRISPR-Cas Genome Editing Using Guide-Complementary DNA Oligonucleotides	3
CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito, Aedes aegypti	3
Periodontal Disease Pathogens, Pathogenesis, and Therapeutics: The CRISPR-Cas Effect	3
Acknowledgment of Reviewers 2021	3
The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells	2
Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells	2
Optimizing Genome Editing in Mollusks ( Crassostrea gigas ) in Vitro Validation of sgRNA and Identifying K	2
Acknowledgment of Reviewers 2024	2
Allele-Specific Inactivation of an Autosomal Dominant Epidermolysis Bullosa Simplex Mutation Using CRISPR-Cas9	2
Functional and Phylogenetic Diversity of Cas10 Proteins	2
A Mutation-Agnostic Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy	2
Special Issue : Manipulating the Microbiome with CRISPR	2
Establishment of a CRISPR-Cas9-Mediated Genome Editing System in Flax	2
Advances in Gene Therapy for Sickle Cell Disease: From Preclinical Innovations to Clinical Implementation and Access Challenges	2
JACKIE: Fast Enumeration of Genome-Wide Single- and Multicopy CRISPR Target Sites and Their Off-Target Numbers	2
Correction to: Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	2
Model System to Analyze RNA-Mediated DNA Repair in Mammalian Cells	2
Impact of KIT Editing on Coat Pigmentation and Fresh Meat Color in Yorkshire Pigs	2
CRISPR and the Plant Pathologists' Holy Grail	2
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for The CRISPR Journal	2
Search for Origins of Anti-CRISPR Proteins by Structure Comparison	2
CRISPR's Path to the Clinic	2
CRISPR Empowers Tree Bioengineering for a Sustainable Future	2
Biotechnologies in the World: On Global Asymmetries and the Need for Cosmopolitanism	2
Special Issue on CRISPR Diagnostics	2
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing	2
Embryonic Stem Cell Research Oversight Committees: A Model for Oversight of Innovative Research?	2
Efficient Generation of SOCS2 Knock-Out Sheep by Electroporation of CRISPR-Cas9 Ribonucleoprotein Complex with Dual-sgRNAs	2
Vulnerability and the Ethics of Human Germline Genome Editing	2
Bacterial Expression System with Deep Repression and Activation via CRISPR-Cas9	2
Monitoring the Land and Sea: Enhancing Efficiency Through CRISPR-Cas Driven Depletion and Enrichment of Environmental DNA	2
Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species	2