CRISPR Journal

Article	Citations
Inference of CRISPR Edits from Sanger Trace Data	312
CRISPRCasTyper: Automated Identification, Annotation, and Classification of CRISPR-Cas Loci	156
Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data	72
Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation	58
Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors	37
Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods	34
CRISPR-Cas12a Genome Editing at the Whole-Plant Level Using Two Compatible RNA Virus Vectors	32
Sensitive and Easy-Read CRISPR Strip for COVID-19 Rapid Point-of-Care Testing	31
Toward a CRISPR-Cas9-Based Gene Drive in the Diamondback Moth Plutella xylostella	30
ON-Target Adverse Events of CRISPR-Cas9 Nuclease: More Chaotic than Expected	30
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	29
A Code of Ethics for Gene Drive Research	27
Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities	26
CRISPR-Cas9-Mediated Gene Editing of MYB28 Genes Impair Glucoraphanin Accumulation of Brassica oleracea in the Field	26
Genome Editing Using the CRISPR-Cas9 System to Generate a Solid-Red Germline of Nile Tilapia (Oreochromis niloticus)	25
Characterization of SHATTERPROOF Homoeologs and CRISPR-Cas9-Mediated Genome Editing Enhances Pod-Shattering Resistance in Brassica napus L.	24
Bacterial Retrons Enable Precise Gene Editing in Human Cells	23
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	23
CRISPR-Assisted DNA Detection: A Novel dCas9-Based DNA Detection Technique	23
Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia	23
CRISPR Arrays Away from cas Genes	22
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing	20
Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease	19
CRISPR-Mediated Synergistic Epigenetic and Transcriptional Control	19
Recent Advances in CRISPR-Based Biosensors for Point-of-Care Pathogen Detection	18

High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells	18
Heritable Human Genome Editing: The Public Engagement Imperative	18
Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia	18
The Transposon-Encoded Protein TnpB Processes Its Own mRNA into ωRNA for Guided Nuclease Activity	17
CRISPR-Cas “Non-Target” Sites Inhibit On-Target Cutting Rates	17
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	16
RNA-Responsive gRNAs for Controlling CRISPR Activity: Current Advances, Future Directions, and Potential Applications	15
CRISPRclassify: Repeat-Based Classification of CRISPR Loci	15
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	15
Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination	15
Strategies for Enhancing the Homology-Directed Repair Efficiency of CRISPR-Cas Systems	15
One-Step Homology Mediated CRISPR-Cas Editing in Zygotes for Generating Genome Edited Cattle	15
Temperature-Inducible Precision-Guided Sterile Insect Technique	14
Programming Cells by Multicopy Chromosomal Integration Using CRISPR-Associated Transposases	14
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	14
A Novel Set of Cas9 Fusion Proteins to Stimulate Homologous Recombination: Cas9-HRs	14
Genetically Encoded CRISPR Components Yield Efficient Gene Editing in the Invasive Pest Drosophila suzukii	13
Catalytically Enhanced Cas9 Through Directed Protein Evolution	13
(Broken) Promises of Sustainable Food and Agriculture through New Biotechnologies: The CRISPR Case	12
Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase–nCas9 Fusions	12
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	12
Improving FnCas12a Genome Editing by Exonuclease Fusion	12
Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence	11
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	11
Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing	11
Development and Characterization of a Modular CRISPR and RNA Aptamer Mediated Base Editing System	11
CALITAS: A CRISPR-Cas-aware ALigner for In silico off-TArget Search	11
New Editing Tools for Gene Therapy in Inherited Retinal Dystrophies	11
Development of a Cas12a-Based Genome Editing Tool for Moderate Thermophiles	10
Increased Efficiency for Biallelic Mutations of theCCR5Gene by CRISPR-Cas9 Using Multiple Guide RNAs As a Novel Therapeutic Option for Human Immunodeficiency Virus	10
The DNA-Dialogue: A Broad Societal Dialogue About Human Germline Genome Editing in the Netherlands	10
Application of CRISPR-Cas9 Editing for Virus Engineering and the Development of Recombinant Viral Vaccines	10
Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing	10
Regulatory Considerations for Clinical Trial Applications with CRISPR-Based Medicinal Products	10
AsCRISPR: A Web Server for Allele-Specific Single Guide RNA Design in Precision Medicine	10
The Cas9 Hammer—and Sickle: A Challenge for Genome Editors	10
Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing	10
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes	9
A Living Organism in your CRISPR Toolbox: Caenorhabditis elegans Is a Rapid and Efficient Model for Developing CRISPR-Cas Technologies	9
A Mutation-Agnostic Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy	9
Novel Type V-A CRISPR Effectors Are Active Nucleases with Expanded Targeting Capabilities	9
Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells	9
RNA Binding Proteins As Regulators of Oxidative Stress Identified by a Targeted CRISPR-Cas9 Single Guide RNA Library	9
Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration	9
Evaluation of Gene Knockouts by CRISPR as Potential Targets for the Genetic Engineering of the Mosquito Culex quinquefasciatus	8
Diversification of the CRISPR Toolbox: Applications of CRISPR-Cas Systems Beyond Genome Editing	8
Natural Nucleoside Modifications in Guide RNAs Can Modulate the Activity of the CRISPR-Cas9 System In Vitro	8
A CRISPR-Cas9, Cre-lox, and Flp-FRT Cascade Strategy for the Precise and Efficient Integration of Exogenous DNA into Cellular Genomes	8
A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation	8
Identification and Evolution of Cas9 tracrRNAs	8

Fast and Efficient Generation of Isogenic Induced Pluripotent Stem Cell Lines Using Adenine Base Editing	8
Cas4–Cas1 Is a Protospacer Adjacent Motif–Processing Factor Mediating Half-Site Spacer Integration During CRISPR Adaptation	8
Allele-Specific Inactivation of an Autosomal Dominant Epidermolysis Bullosa Simplex Mutation Using CRISPR-Cas9	8
Advances in CRISPR Delivery Methods: Perspectives and Challenges	7
On- and Off-Target Analyses of CRISPR-Cas12b Genome Editing Systems in Rice	7
Miniature CRISPR-Cas12f1-Mediated Single-Nucleotide Microbial Genome Editing Using 3′-Truncated sgRNA	7
A Meta-Analysis of gRNA Library Screens Enables an Improved Understanding of the Impact of gRNA Folding and Structural Stability on CRISPR-Cas9 Activity	7
Dead Cas9–sgRNA Complex Shelters Vulnerable DNA Restriction Enzyme Sites from Cleavage for Cloning Applications	7
Regulation of Gene Expression and the Elucidative Role of CRISPR-Based Epigenetic Modifiers and CRISPR-Induced Chromosome Conformational Changes	7
Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins	6
Site-Specific Labeling Reveals Cas9 Induces Partial Unwinding Without RNA/DNA Pairing in Sequences Distal to the PAM	6
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	6
CRISPRa-Mediated Upregulation of scn1laa During Early Development Causes Epileptiform Activity and dCas9-Associated Toxicity	6
A Decade of CRISPR Gene Editing in China and Beyond: A Scientometric Landscape	6
The View from the Benches: Scientists' Perspectives on the Uses and Governance of Human Gene-Editing Research	6
CRISPR-Associated Transposase System Can Insert Multiple Copies of Donor DNA into the Same Target Locus	5
Multiplex Editing of the Nucleoredoxin1 Tandem Array in Poplar: From Small Indels to Translocations and Complex Inversions	5
Multiplex gRNAs Synergically Enhance Detection of SARS-CoV-2 by CRISPR-Cas12a	5
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	5
Multiplex Gene Tagging with CRISPR-Cas9 for Live-Cell Microscopy and Application to Study the Role of SARS-CoV-2 Proteins in Autophagy, Mitochondrial Dynamics, and Cell Growth	5
Functional and Phylogenetic Diversity of Cas10 Proteins	5
Immaculate Conception? Priority and Invention in the CRISPR Patent Dispute	5
Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic	5
Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity	5
Vulnerability and the Ethics of Human Germline Genome Editing	5
Impact of KIT Editing on Coat Pigmentation and Fresh Meat Color in Yorkshire Pigs	5
Locus-Specific Genomic DNA Purification Using the CRISPR System: Methods and Applications	5
Functional Characterization of Type III-A CRISPR-Cas in a Clinical Human Methicillin-R Staphylococcus aureus Strain	5
Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors	5
CRISPR-Cas9 Technology as a Tool to Target Gene Drivers in Cancer: Proof of Concept and New Opportunities to Treat Chronic Myeloid Leukemia	5
CRISPR Hits Home in a First-in-Human Study	5
Universal Gene Correction Approaches for β-hemoglobinopathies Using CRISPR-Cas9 and Adeno-Associated Virus Serotype 6 Donor Templates	5
Deep Sequencing Reveals the Comprehensive CRISPR-Cas9 Editing Spectrum in Bombyx mori	5
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells	4
Governing Heritable Human Genome Editing: A Textual History and a Proposal for the Future	4
Engineered Antiviral Sensor Targets Infected Mosquitoes	4
Efficient and Fast Generation of Relevant Disease Mouse Models by In Vitro and In Vivo Gene Editing of Zygotes	4
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences	4
Base Editing of Somatic Cells Using CRISPR–Cas9 in Drosophila	4
Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability	4
Induction and Elimination of Prophages Using CRISPR Interference	4
Optimized Guide RNA Selection Improves Streptococcus pyogenes Cas9 Gene Editing of Human Hematopoietic Stem and Progenitor Cells	4
Replication Protein Rep Provides Selective Advantage to Viruses in the Presence of CRISPR-Cas Immunity	4
Enhanced Taq Variant Enables Efficient Genome Editing Testing and Mutation Detection	4
Determination of Factors Driving the Genome Editing Field in the CRISPR Era Using Bibliometrics	4
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	4
The CRISPR Patent Landscape: Focus on Chinese Researchers	4
Pseudogene-Mediated Gene Conversion After CRISPR-Cas9 Editing Demonstrated by Partial CD33 Conversion with SIGLEC22P	4
GeneTargeter: Automated In Silico Design for Genome Editing in the Malaria Parasite, Plasmodium falciparum	4
A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs	4
Functional Study of the Type II-A CRISPR-Cas System of Streptococcus agalactiae Hypervirulent Strains	4
gEL DNA: A Cloning- and Polymerase Chain Reaction–Free Method for CRISPR-Based Multiplexed Genome Editing	4
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	4
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	4
CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito, Aedes aegypti	3
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	3
Gene-Edited Fluorescent and Mixed Cerebral Organoids	3
Optimization of Genomewide CRISPR Screens Using AsCas12a and Multi-Guide Arrays	3
In Vitro CRISPR-Cas12a-Based Detection of Cancer-Associated TP53 Hotspot Mutations Beyond the crRNA Seed Region	3
CRISPR and Long-Read Sequencing: A Perfect Match	3
Periodontal Disease Pathogens, Pathogenesis, and Therapeutics: The CRISPR-Cas Effect	3
CRISPR-Cas-Based Biomonitoring for Marine Environments: Toward CRISPR RNA Design Optimization Via Deep Learning	3
A Novel System for Simple Rapid Adenoviral Vector Construction to Facilitate CRISPR/Cas9-Mediated Genome Editing	3
Self-Cutting and Integrating CRISPR Plasmids Enable Targeted Genomic Integration of Genetic Payloads for Rapid Cell Engineering	3
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	3
JACKIE: Fast Enumeration of Genome-Wide Single- and Multicopy CRISPR Target Sites and Their Off-Target Numbers	3
Expanding the Toolkit for Genome Editing in a Disease Vector, Aedes aegypti: Transgenic Lines Expressing Cas9 and Single Guide RNA Induce Efficient Mutagenesis	3
The Art of Being Single	3
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies	3
CASPER: An Integrated Software Platform for Rapid Development of CRISPR Tools	3
GOANA: A Universal High-Throughput Web Service for Assessing and Comparing the Outcome and Efficiency of Genome Editing Experiments	3
Search for Origins of Anti-CRISPR Proteins by Structure Comparison	3
The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells	3
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome	3
Chimeric RNA: DNA TracrRNA Improves Homology-Directed Repair In Vitro and In Vivo	2
PASTE: The Way Forward for Large DNA Insertions	2
Amplifying CRISPR: Next-Generation Diagnostics	2
Assessing Off-Target Editing of CRISPR-Cas9 Systems	2
A Taxonomic and Phylogenetic Classification of Diverse Base Editors	2
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	2

Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	2
Easy-to-Use CRISPR-Cas9 Genome Editing in the Cultured Pacific Abalone (Haliotis discus hannai)	2
A Bioluminescence Resonance Energy Transfer–Based Reporter System: Characterization and Applications	2
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	2
SuperFi-Cas9: High Fidelity Meets High Activity	2
Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes	2
Expression of Cas9 in a Syngeneic Model of Primary Central Nervous System Lymphoma Induces Intracerebral NK and CD8 T Cell-Mediated Lymphoma Cell Lysis Via Perforin	2
Transversion Expansion of Base Editing	2
Can Deep Learning Solve the Cas9 Dilemma?	2
Rapid Whole-Genome Identification of High Quality CRISPR Guide RNAs with the Crackling Method	2
SCRAMBLER: A Tool for De Novo CRISPR Array Reconstruction and Its Application for Analysis of the Structure of Prokaryotic Populations	2
Highly Efficient One-Step Tagging of Endogenous Genes in Primary Cells Using CRISPR-Cas Ribonucleoproteins	2
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa	2
Gene Editing and Rett Syndrome: Does It Make the Cut?	2
A CRISPR-dCas9 System for Assaying and Selecting for RNase III Activity In Vivo in Escherichia coli	2
APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels	2
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	2