OOIR: Observatory of International Research

Papers

(The median citation count of CRISPR Journal is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Subtypes of Type I-E CRISPR-Cas Systems Distribution in Human Escherichia coli Isolates from China	48
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	37
Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions	36
Will Advances in Genetic Medicine Lessen the Need for Germline Modifications?	35
Hairpin Internal Nuclear Localization Signals in CRISPR-Cas9 Enhance Editing in Primary Human Lymphocytes	33
Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	30
Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types	29
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	28
Gene Editing and Rett Syndrome: Does It Make the Cut?	24
Acknowledgment of Reviewers 2022	23
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	23
Opposing Human Genetic Engineering	22
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	20
The Lexicon of CRISPR: When Is It Too Much?	20
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	18
Curing “GFP-itis” in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students	18
Early Detection of Wildlife Disease Pathogens Using CRISPR-Cas System Methods	17
Efficient Installation of Heterozygous Mutations in Human Pluripotent Stem Cells Using Prime Editing	17
Viability-Based Assessment Reveals True Efficiency of CRISPR-Cas9 Transfection Methods in Rabbit Spermatozoa	16
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	15
CRISPR Crops and Sustainable Agriculture	15
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing	15
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	14
The Roles and Responsibilities of Scientific Journals in Research Governance: Editorial Policymaking at Nature and Springer Nature (1995–2023)	14
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	13

Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes	13
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	13
Institutional Bioethics: From Critical Interdisciplinarity to Cosmopolitanism	13
Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR	13
CRISPR-Cas9 Single Nucleotide Editing of Tuberous Sclerosis Complex 2 Gene in Mesenchymal Stem Cells	13
Engineered Antiviral Sensor Targets Infected Mosquitoes	12
A Story of Perseverance: An Interview with Matthew Porteus	12
dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer	12
Regulatory Support for CRISPR in Ag: A Timely EU-Turn	12
Affordable Pricing of CRISPR Treatments is a Pressing Ethical Imperative	11
CRISPR Momentum in the Clinic and the Field	11
Engineering CjCas9 for Efficient Base Editing and Prime Editing	11
Conditional Expression of Cas9 and dCas9 in Lucilia cuprina Reveals dCas9-Associated Lethality	11
Fanzors: Mysterious TnpB-Like Bacterial Transposon-Related RNA-Guided DNA Nucleases of Eukaryotes	11
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors	11
Enhancements of the CRISPR-Cas System in the Silkworm Bombyx mori	11
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	11
Efficient CRISPR-Cas9-Mediated Genome Editing of the Cane Toad ( Rhinella marina )	10
It's a Knockout for Cat Allergies?	10
A PCR-Induced Mutagenesis-Restriction Fragment Length Polymorphism Method for the Detection of CRISPR-Induced Indels	10
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	10
Cas12a-Capture: A Novel, Low-Cost, and Scalable Method for Targeted Sequencing	10
Navigating Viral Space with CRISPR Technologies	9
A Protein-Cutting CRISPR Complex Caught in Action	9
Introducing Faith-Based Claims to Ethical Discourse on Scientific Matters	9
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	9
CRISPR-Cas9-Mediated Correction of TSC2 Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2	9
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13	9
Five Years of Progress in CRISPR Clinical Trials (2019–2024)	8
Acknowledgment of Reviewers 2023	8
Rapid Variant Pathogenicity Analysis by CRISPR Activation of CRB1 Gene Expression in Patient-Derived Fibroblasts	8
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects	7
Genome Editing Headwinds: Can CRISPR Stay on Target?	7
Special Issue : Manipulating the Microbiome with CRISPR	7
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells	7
The New Old Colonialism	7
Correction to: APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels by Rieffer et al. The CRISPR Journal	7
CRISPR Medicine Needs Infrastructure, Not Just Innovation	7
Moving Therapeutic Genome Editing into Global Clinical Trials and Medicine	7
Strategies for Interdisciplinary Human Gene Editing Research: Insights from a Swiss Project	7
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	7
Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity	6
Extreme Genome Editing	6
Novel off-Targeting Events Identified after Genome Wide Analysis of CRISPR-Cas Edited Pigs	6
Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic	6
Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities	6
A Reset for Bioethics: A Statement from the Global Observatory for Genome Editing	6
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome	6
Recalibrating Health Governance, Equity, and Reproductive Rights in India: A Case Study from the Global South	6
Characterization of Research Support of Genome Editing Technologies and Transition to Clinical Trials	6

PASTE: The Way Forward for Large DNA Insertions	6
Special Issue : CRISPR Trials	6
Correction to: Give Cas a Chance: An Actionable Path to a Platform for CRISPR Cures , by Fyodor D. Urnov [DOI: 10.1089/crispr.2024.0082]	6
An Efficient and Cost-Effective Novel Strategy for Identifying CRISPR-Cas-Mediated Mutants in Plant Offspring	5
Optimization of Genome-Wide CRISPR Screens Using Dual-Guide RNA Infection with Cas9 Electroporation (DICE)	5
Optimization of Genomewide CRISPR Screens Using AsCas12a and Multi-Guide Arrays	5
Cosmopolitan Bioethics Under Pressure: Reflections on the Global Observatory for Genome Editing International Summit	5
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes	5
BAR-CAT: Targeted Recovery of Synthetic Genes via Barcode-Directed CRISPR-dCas9 Enrichment	5
Celebrating a Decade of CRISPR-Fueled Genome Editing	5
CRISPR-Cas9-Mediated Targeting of Multidrug Resistance Genes in Methicillin-Resistant Staphylococcus aureus	5
Introducing Perspectives from the Global Observatory for Genome Editing	5
Facing Systemic Uncertainty, Can the CRISPR Community Stay the Course?	4
Correction to: Genotyping MUltiplexed-Sequencing of CRISPR-Localized Editing (GMUSCLE): An Experimental and Computational Approach for Analyzing CRISPR-Edited Cells	4
Science with Society at Science Gallery Bengaluru	4
Predicting Mutations Generated by Cas9, Base Editing, and Prime Editing in Mammalian Cells	4
Toward a Global Deliberative System for Genome Editing	4
Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing	4
APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels	4
A Phage Variable Region Encodes Anti-CRISPR Proteins Inhibiting All Streptococcus thermophilus CRISPR Immune Systems	4
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences	4
Modified Cas9-Guided Oxford Nanopore Technology Sequencing Uncovers Single and Multiple Transgene Insertion Sites in a Zebrafish Melanoma Model	4
Viral Delivery of Compact CRISPR-Cas12f for Gene Editing Applications	4
Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability	4
Response to Cook et al. re: Novel Off-Targeting Events Identified After Genome Wide Analysis of CRISPR-Cas Edited Pig	4
Advances in Gene Therapy for Sickle Cell Disease: From Preclinical Innovations to Clinical Implementation and Access Challenges	3
Highly Efficient One-Step Tagging of Endogenous Genes in Primary Cells Using CRISPR-Cas Ribonucleoproteins	3
Periodontal Disease Pathogens, Pathogenesis, and Therapeutics: The CRISPR-Cas Effect	3
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa	3
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies	3
CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito, Aedes aegypti	3
Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species	3
The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells	3
Genome Editing in Apicomplexan Parasites: Current Status, Challenges, and Future Possibilities	3
Modulating CRISPR-Cas Genome Editing Using Guide-Complementary DNA Oligonucleotides	3
AI and SynBio Meet CRISPR Heralding a New Genome Editing Era	3
Biotechnologies in the World: On Global Asymmetries and the Need for Cosmopolitanism	3
JACKIE: Fast Enumeration of Genome-Wide Single- and Multicopy CRISPR Target Sites and Their Off-Target Numbers	3
A “Bare Hope of A Result”: The Second CRISPR Patent Appeal	3
Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of a dCas9 Ribonucleoprotein Complex	3
Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells	2
Special Issue : Manipulating the Microbiome with CRISPR	2
CRISPR Empowers Tree Bioengineering for a Sustainable Future	2
CRISPR and the Plant Pathologists' Holy Grail	2
Acknowledgment of Reviewers 2024	2
Model System to Analyze RNA-Mediated DNA Repair in Mammalian Cells	2
Bacterial Expression System with Deep Repression and Activation via CRISPR-Cas9	2
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing	2
Establishment of a CRISPR-Cas9-Mediated Genome Editing System in Flax	2
Efficient Generation of SOCS2 Knock-Out Sheep by Electroporation of CRISPR-Cas9 Ribonucleoprotein Complex with Dual-sgRNAs	2
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for The CRISPR Journal	2
Embryonic Stem Cell Research Oversight Committees: A Model for Oversight of Innovative Research?	2
Functional and Phylogenetic Diversity of Cas10 Proteins	2
Optimizing Genome Editing in Mollusks ( Crassostrea gigas ) in Vitro Validation of sgRNA and Identifying K	2
Allele-Specific Inactivation of an Autosomal Dominant Epidermolysis Bullosa Simplex Mutation Using CRISPR-Cas9	2
Correction to: Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	2
Monitoring the Land and Sea: Enhancing Efficiency Through CRISPR-Cas Driven Depletion and Enrichment of Environmental DNA	2
Vulnerability and the Ethics of Human Germline Genome Editing	2
CRISPR-AsCas12a Efficiently Corrects a GPR143 Intronic Mutation in Induced Pluripotent Stem Cells from an Ocular Albinism Patient	2
Search for Origins of Anti-CRISPR Proteins by Structure Comparison	2