OOIR: Observatory of International Research

Papers

(The TQCC of JOR Spine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
	94
	78
	73
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	67
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	53
Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study	42
Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease	39
The effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration	34
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	33
Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	28
Injection Volume Is a Better Predictor of Stiffness Restoration Than Injection Force in an In Vitro Study of Nucleus Augmentation of the Intervertebral Disc	28
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells	26
Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs	23
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants	22
TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model	20
Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?	20
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	18
Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise	16
Issue Information	16
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy	15
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc	15
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	15
	14
Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	14
Evaluation of instrumentation and pedicle screw design for posterior lumbar fixation: A pre‐clinical in vivo/ex vivo ovine model	14

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	13
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	13
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique	13
	13
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	13
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells	13
Biomedical applications of silk and its role for intervertebral disc repair	12
Issue Information	12
Issue Information	12
Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype	11
Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow‐up	10
Deep learning‐based structure segmentation and intramuscular fat annotation on lumbar magnetic resonance imaging	10
How to improve the mechanical safety of a novel spinal implant while saving costs and time	10
Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions	10
Static study and numerical simulation of the influence of cement distribution in the upper and lower adjacent vertebrae on sandwich vertebrae in osteoporotic patients: Finite element analysis	10
Clinical implications of linking microstructure, spatial biochemical, spatial biomechanical, and radiological features in ligamentum flavum degeneration	10
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	10
The Cross‐Sectional Areas and Anterior–Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score‐Matched Analysis	9
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	9
Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor‐Related Gene Analysis	9
Correction to “Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs”	9
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	8
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	8
Associations between femoral 3D curvature and sagittal imbalance of spine	8
Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks	8
The Helical Compliance Vector: Utility for Quantifying Spinal Mechanics	8
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	8
Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model	8
Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions	7
Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc	7
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	7
Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	7
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	7
Density and mechanical properties of vertebral trabecular bone—A review	7
	7
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs	7
Silibinin promotes healing in spinal cord injury through anti‐ferroptotic mechanisms	7
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	7
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines	6
Enhancing Clinical Insights: New Radiographic Grading for Lumbar Facet Joint Degeneration, A Reliability Study	6
Analysis of the value of potential biomarker S100‐A8 protein in the diagnosis and pathogenesis of spinal tuberculosis	6
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network	6
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	6
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study	6
Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging‐Based Subject‐Specific Musculoskeletal Models	6
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	6
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	5
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health	5
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	5
Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral	5

	5
Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	5
Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study	5
Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology	5
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	5
Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders	5
Unilateral Lumbo‐Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis	5
Issue Information	5
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	5