OOIR: Observatory of International Research

Papers

(The TQCC of JOR Spine is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
	100
Injection Volume Is a Better Predictor of Stiffness Restoration Than Injection Force in an In Vitro Study of Nucleus Augmentation of the Intervertebral Disc	87
Exploring the Biopsychosocial Impact of Chronic Low Back Pain in Workers Through Artificial Intelligence‐Driven Phenotyping	77
Feasibility of Physical Exam and Performance‐Based Tests in Individuals With Chronic Low Back Pain: A Descriptive Study	56
Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study	51
Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease	42
The effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration	36
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	36
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	35
	31
Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	23
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	22
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	22
TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model	22
Issue Information	19
Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise	18
Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?	17
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy	17
Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs	16
Evaluation of instrumentation and pedicle screw design for posterior lumbar fixation: A pre‐clinical in vivo/ex vivo ovine model	16
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc	16
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique	16
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells	16
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants	16
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	16

Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	15
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	15
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	15
Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats	14
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells	13
Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	13
	13
	12
Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow‐up	12
Issue Information	12
Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype	12
Issue Information	11
How to improve the mechanical safety of a novel spinal implant while saving costs and time	11
Clinical implications of linking microstructure, spatial biochemical, spatial biomechanical, and radiological features in ligamentum flavum degeneration	11
Biomedical applications of silk and its role for intervertebral disc repair	10
Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions	10
Deep learning‐based structure segmentation and intramuscular fat annotation on lumbar magnetic resonance imaging	10
Static study and numerical simulation of the influence of cement distribution in the upper and lower adjacent vertebrae on sandwich vertebrae in osteoporotic patients: Finite element analysis	10
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs	9
Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor‐Related Gene Analysis	9
Lumbopelvic Kinematics During Functional Tasks in a Chronic Low Back Pain Observational Cohort	9
The Helical Compliance Vector: Utility for Quantifying Spinal Mechanics	9
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	9
Correction to “Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs”	9
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	9
Associations between femoral 3D curvature and sagittal imbalance of spine	9
Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks	9
The Cross‐Sectional Areas and Anterior–Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score‐Matched Analysis	9
Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions	8
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	8
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	8
Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc	8
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	8
Silibinin promotes healing in spinal cord injury through anti‐ferroptotic mechanisms	8
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	8
Density and mechanical properties of vertebral trabecular bone—A review	8
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	8
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	7
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study	7
Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging‐Based Subject‐Specific Musculoskeletal Models	7
Single‐Side Iatrogenic Pedicle Injury May Trigger an Increased Risk of Contralateral Screw Loosening: An In Silico Study	7
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	7
	7
Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	7
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network	7
Analysis of the value of potential biomarker S100‐A8 protein in the diagnosis and pathogenesis of spinal tuberculosis	7
	7
Enhancing Clinical Insights: New Radiographic Grading for Lumbar Facet Joint Degeneration, A Reliability Study	7
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines	7
Plasma Pro‐ and Anti‐Inflammatory Cytokines in an Observational Chronic Low Back Pain Cohort	7

Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	7
Unilateral Lumbo‐Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis	7
Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral	6
Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading	6
Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment	6
Issue Information	6
Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc	6
Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress‐Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy	6
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	6
Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study	6
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	6
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	6