OOIR: Observatory of International Research

Papers

(The median citation count of JOR Spine is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Vascularization of the human intervertebral disc: A scoping review	58
Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section	47
Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders	41
The involvement of immune system in intervertebral disc herniation and degeneration	35
Density and mechanical properties of vertebral trabecular bone—A review	33
Cell sources proposed for nucleus pulposus regeneration	32
Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative	28
Spine biomechanical testing methodologies: The controversy of consensus vs scientific evidence	28
Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative	25
Electrospinning and 3D bioprinting for intervertebral disc tissue engineering	22
Advanced glycation end products cause RAGE‐dependent annulus fibrosus collagen disruption and loss identified using in situ second harmonic generation imaging in mice intervertebral disk in	21
Using embedded alginate microparticles to tune the properties of in situ forming poly(N‐isopropylacrylamide)‐graft‐chondroitin sulfate bioadhesive hydrogels for replacement and repair of the nu	20
Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha	20
A comprehensive tool box for large animal studies of intervertebral disc degeneration	19
Adolescent idiopathic scoliosis: The mechanobiology of differential growth	19
Optimization of a rat lumbar IVD degeneration model for low back pain	18
Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis	16
Spatial mapping of collagen content and structure in human intervertebral disk degeneration	15
Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design	15
The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency	15
Structure‐function relationships of the human vertebral endplate	13
Cell populations and muscle fiber morphology associated with acute and chronic muscle degeneration in lumbar spine pathology	13
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	13
Intervertebral disc degeneration and how it leads to low back pain	12
Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations	12

Automatic detection and voxel‐wise mapping of lumbar spine Modic changes with deep learning	11
Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORSspine section	11
Influence of testing environment and loading rate on intervertebral disc compressive mechanics: An assessment of repeatability at three different laboratories	11
Atomic force microscopy imaging for nanoscale and microscale assessments of extracellular matrix in intervertebral disc and degeneration	11
Characterization of bovine and canine animal model cartilage endplates and comparison to human cartilage endplate structure, matrix composition, and cell phenotype	10
Effects of suppressing bioavailability of insulin‐like growth factor on age‐associated intervertebral disc degeneration	10
Generation of an in vitro model of the outer annulus fibrosus‐cartilage interface	10
Canine models of spine disorders	10
Consolidating and re‐evaluating the human disc nutrient microenvironment	10
Assessing the use of finite element analysis for mechanical performance evaluation of intervertebral body fusion devices	9
A challenging playing field: Identifying the endogenous impediments to annulus fibrosus repair	9
Comparing cellular bone matrices for posterolateral spinal fusion in a rat model	9
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration	9
An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therape	8
Effects of systemically administered abaloparatide, an osteoanabolic PTHrP analog, as an adjuvant therapy for spinal fusion in rats	8
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation	8
Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential	8
Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues	8
The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs	8
Measuring the neutral zone of spinal motion segments: Comparison of multiple analysis methods to quantify spinal instability	8
Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties	8
Clinically relevant finite element technique based protocol to evaluate growing rods for early onset scoliosis correction	8
An optimized step‐by‐step protocol for isolation of nucleus pulposus, annulus fibrosus, and end plate cells from the mouse intervertebral discs and subsequent preparation of high‐quality intact total	7
Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain	7
Quantitative identification and segmentation repeatability of thoracic spinal muscle morphology	7
Intradiscal injection for the management of low back pain	7
Verteporfin treatment controls morphology, phenotype, and global gene expression for cells of the human nucleus pulposus	7
Mechanical and biological characterization of a composite annulus fibrosus repair strategy in an endplate delamination model	7
TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs	7
Comparison and optimization of sheep in vivo intervertebral disc injury model	7
Validity of flexicurve and motion capture for measurements of thoracic kyphosis vs standing radiographic measurements	7
Confocal scanning of intervertebral disc cells in 3D: Inside alginate beads and in native microenvironment	7
Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain‐related behavior	7
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	6
Age‐related molecular changes in the lumbar dorsal root ganglia of mice: Signs of sensitization, and inflammatory response	6
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	6
Harmonization and standardization of nucleus pulposus cell extraction and culture methods	6
Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies	6
COVID‐19: Current and future challenges in spine care and education ‐ a worldwide study	6
Protocol for parallel proteomic and metabolomic analysis of mouse intervertebral disc tissues	6
Optimal machine learning methods for radiomic prediction models: Clinical application for preoperative T₂*‐weighted images of cervical spondylotic myelopathy	5
In vitro nucleus pulposus tissue model with physicochemical stresses	5
Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice	5
Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth	5
N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass produc	5
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	5
Thoracic vertebral morphology in normal and scoliosis deformity in skeletally immature rabbits: A Longitudinal study	5
Single level posterolateral lumbar fusion in a New Zealand White rabbit (Oryctolagus cuniculus) model: Surgical anatomy, operative technique, autograft fusion rates, and perioperativ	5
Evaluation of lumbar spinal fusion utilizing recombinant human platelet derived growth factor‐B chain homodimer (rhPDGF‐BB) combined with a bovine collagen/β‐tricalcium phosphate (β‐TC	5
The mechano‐response of murine annulus fibrosus cells to cyclic tensile strain is frequency dependent	4

Imaging the local biochemical content of native and injured intervertebral disc using Fourier transform infrared microscopy	4
Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model	4
Electrospun biodegradable poly(ε‐caprolactone) membranes for annulus fibrosus repair: Long‐term material stability and mechanical competence	4
Preliminary investigation of spinal level and postural effects on thoracic muscle morphology with upright openMRI	4
Sacral anatomical parameters varies in different Roussouly sagittal shapes as well as their relations to lumbopelvic parameters	4
PHLPP1 deficiency protects against age‐related intervertebral disc degeneration	4
Dried plum mitigates spinal cord injury‐induced bone loss in mice	4
Biomedical applications of silk and its role for intervertebral disc repair	4
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc	4
TNFAIP8 family gene expressions in the mouse tail intervertebral disc injury model	3
Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates	3
An in vitro 3D annulus fibrosus cell culture model with type I collagen: An examination of cell–matrix interactions	3
Species variation in the cartilaginous endplate of the lumbar intervertebral disc	3
Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia	3
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region	3
Impact of pulse sequence, analysis method, and signal to noise ratio on the accuracy of intervertebral disc T₂ measurement	3
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review	3
Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	2
The influence of intervertebral disc overloading on nociceptor calcium flickering	2
Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression	2
Single‐level cervical disc arthroplasty in the spine with reversible kyphosis: A finite element study	2
Investigation of in vivo three‐dimensional changes of the spinal canal after corrective surgeries of the idiopathic scoliosis	2
IL‐1Ra deficiency accelerates intervertebral disc degeneration in C57BL6J mice	2
Socioeconomic status, mental health, and nutrition are the principal traits for low back pain phenotyping: Data from the osteoarthritis initiative	2
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	2
Hyperosmolar expansion medium improves nucleus pulposus cell phenotype	2
High throughput computational evaluation of how scaffold architecture, material selection, and loading modality influence the cellular micromechanical environment in tissue engineering strategies	2
Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research	2
Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study	2
Investigation into the anti‐inflammatory properties of metformin in intervertebral disc cells	2
A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series	2
Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration	2
MRI‐based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading	2
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	2
Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix	2
Restoration of physiologic loading modulates engineered intervertebral disc structure and function in an in vivo model	2
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model	2
Influence of patient‐specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls	2
Effect of contrast media on the enzyme activity of condoliase: In vitro assessment	1
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis	1
TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc	1
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	1
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model	1
The temporal and spatial expression of sclerostin and Wnt signaling factors during the maturation of posterolateral lumbar spine fusions	1
Improving reproducibility in spine research	1
Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences	1
DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling	1
Effect of voluntary running activity on mRNA expression of extracellular matrix genes in a mouse model of intervertebral disc degeneration	1
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	1
Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments	1
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research	1
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes	1
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	1
L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc	1
Inorganic polyphosphates stimulates matrix production in human annulus fibrosus cells	1
Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	1
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	1
Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model	1
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	1
The research landscape of immunology research in spinal cord injury from 2012 to 2022	1
Optimal intermittent administration interval of parathyroid hormone 1‐34 for bone morphogenetic protein‐induced bone formation in a rat spinal fusion model	1
Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture	1
An in vitro comparison of three nucleus pulposus removal techniques for partial intervertebral disc replacement: An ultra‐high resolution MRI study	1
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	1
Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	1
Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model	1
Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading	1
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	1
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	1
Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury	1
Analysis of cell‐free circulating DNA fragment size and level in patients with lumbar canal stenosis	1
Thresholding approaches for estimating paraspinal muscle fat infiltration using T1‐ and T2‐weighted MRI: Comparative analysis using water–fat MRI	1
Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity	1
Osteoconductivity and neurotoxicity of silver‐containing hydroxyapatite coating cage for spinal interbody fusion in rats	1