OOIR: Observatory of International Research

Papers

(The median citation count of JOR Spine is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The involvement of immune system in intervertebral disc herniation and degeneration	59
Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section	58
Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders	55
Density and mechanical properties of vertebral trabecular bone—A review	49
Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative	42
Cell sources proposed for nucleus pulposus regeneration	41
Spine biomechanical testing methodologies: The controversy of consensus vs scientific evidence	39
Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative	31
Intervertebral disc degeneration and how it leads to low back pain	30
A comprehensive tool box for large animal studies of intervertebral disc degeneration	24
Using embedded alginate microparticles to tune the properties of in situ forming poly(N‐isopropylacrylamide)‐graft‐chondroitin sulfate bioadhesive hydrogels for replacement and repair of the nu	23
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration	20
The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency	19
Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design	18
Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis	18
Spatial mapping of collagen content and structure in human intervertebral disk degeneration	18
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	18
Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain	17
Structure‐function relationships of the human vertebral endplate	16
Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORSspine section	15
An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therape	15
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	14
Consolidating and re‐evaluating the human disc nutrient microenvironment	13
Intradiscal injection for the management of low back pain	13
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	12

Harmonization and standardization of nucleus pulposus cell extraction and culture methods	12
Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research	11
Effects of systemically administered abaloparatide, an osteoanabolic PTHrP analog, as an adjuvant therapy for spinal fusion in rats	11
A challenging playing field: Identifying the endogenous impediments to annulus fibrosus repair	11
Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential	11
Assessing the use of finite element analysis for mechanical performance evaluation of intervertebral body fusion devices	11
TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs	11
Automatic detection and voxel‐wise mapping of lumbar spine Modic changes with deep learning	11
Biomedical applications of silk and its role for intervertebral disc repair	11
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research	10
Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties	10
N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass produc	9
Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain‐related behavior	9
Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies	9
Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration	9
The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs	9
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation	8
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	8
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review	8
Comparison and optimization of sheep in vivo intervertebral disc injury model	7
Single level posterolateral lumbar fusion in a New Zealand White rabbit (Oryctolagus cuniculus) model: Surgical anatomy, operative technique, autograft fusion rates, and perioperativ	7
Sacral anatomical parameters varies in different Roussouly sagittal shapes as well as their relations to lumbopelvic parameters	7
Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice	7
Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study	7
Species variation in the cartilaginous endplate of the lumbar intervertebral disc	7
Socioeconomic status, mental health, and nutrition are the principal traits for low back pain phenotyping: Data from the osteoarthritis initiative	6
Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model	6
Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates	6
Evaluation of lumbar spinal fusion utilizing recombinant human platelet derived growth factor‐B chain homodimer (rhPDGF‐BB) combined with a bovine collagen/β‐tricalcium phosphate (β‐TC	6
MRI‐based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading	6
Optimal machine learning methods for radiomic prediction models: Clinical application for preoperative T₂*‐weighted images of cervical spondylotic myelopathy	6
PHLPP1 deficiency protects against age‐related intervertebral disc degeneration	6
Electrospun biodegradable poly(ε‐caprolactone) membranes for annulus fibrosus repair: Long‐term material stability and mechanical competence	6
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	5
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis	5
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	5
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc	5
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region	4
The role of the complement system in disc degeneration and Modic changes	4
Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model	4
Investigation into theanti‐inflammatoryproperties of metformin in intervertebral disc cells	4
TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc	4
Preliminary investigation of spinal level and postural effects on thoracic muscle morphology with upright openMRI	4
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes	4
Evaluation of the efficacy of modal analysis in predicting the pullout strength of fixation bone screws	4
Osteoconductivity and neurotoxicity of silver‐containing hydroxyapatite coating cage for spinal interbody fusion in rats	3
Effect of contrast media on the enzyme activity of condoliase: In vitro assessment	3
Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	3
The influence of intervertebral disc overloading on nociceptor calcium flickering	3
Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture	3

M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	3
The research landscape of immunology research in spinal cord injury from 2012 to 2022	3
Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading	3
Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments	3
IL‐1Ra deficiency accelerates intervertebral disc degeneration in C57BL6J mice	3
A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series	3
Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia	3
Effect of voluntary running activity on mRNA expression of extracellular matrix genes in a mouse model of intervertebral disc degeneration	3
L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc	3
An in vitro 3D annulus fibrosus cell culture model with type I collagen: An examination of cell–matrix interactions	3
An in vitro comparison of three nucleus pulposus removal techniques for partial intervertebral disc replacement: An ultra‐high resolution MRI study	3
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model	3
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	3
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	3
Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury	3
Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	3
Optimal intermittent administration interval of parathyroid hormone 1‐34 for bone morphogenetic protein‐induced bone formation in a rat spinal fusion model	3
High throughput computational evaluation of how scaffold architecture, material selection, and loading modality influence the cellular micromechanical environment in tissue engineering strategies	3
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	2
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	2
An exploration of knowledge‐organizing technologies to advance transdisciplinary back pain research	2
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	2
Investigation of in vivo three‐dimensional changes of the spinal canal after corrective surgeries of the idiopathic scoliosis	2
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	2
Fibrotic and inflammatory characteristics of epidural fat adjacent to the ossification area in patients with ossification of the ligament flavum	2
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	2
Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression	2
Hyperosmolar expansion medium improves nucleus pulposus cell phenotype	2
Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix	2
Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment	2
Influence of patient‐specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls	2
Dynamics of N6‐methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc	2
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	2
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	2
DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling	2
Single‐level cervical disc arthroplasty in the spine with reversible kyphosis: A finite element study	2
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	2
Links among MRI features in paraspinal muscles, inflammatory processes, and related back pain in patients with lumbar disc herniation	2
Thresholding approaches for estimating paraspinal muscle fat infiltration using T1‐ and T2‐weighted MRI: Comparative analysis using water–fat MRI	1
Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity	1
Construction of circ_0071922‐miR‐15a‐5p‐mRNA network in intervertebral disc degeneration by RNA‐sequencing	1
Characterization and modulation of the pro‐inflammatory effects of immune cells in the canine intervertebral disk	1
	1
Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model	1
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model	1
Bioinformatics‐based discovery of intervertebral disc degeneration biomarkers and immune‐inflammatory infiltrates	1
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	1
Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization	1
A missense GDF5 variant causes brachydactyly type A1 and multiple‐synostoses syndrome 2	1
Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content	1
Automatic grading of intervertebral disc degeneration in lumbar dog spines	1
Facet joint degeneration—An initial procedure of the cervical spine degeneration	1
Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	1
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	1
Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	1
Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	1
A comprehensive review of cell transplantation and platelet‐rich plasma therapy for the treatment of disc degeneration‐related back and neck pain: A systematic evidence‐based analysis	1
Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences	1
Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration	1
Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features	1
Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion	1
Effects of circulating inflammatory proteins on spinal degenerative diseases: Evidence from genetic correlations and Mendelian randomization study	1
Disc geometry measurement methods affect reported compressive mechanics by up to 65%	1
Improving how orthopedic journals report research outcomes based on sex and gender	1
Automatic Lenke classification of adolescent idiopathic scoliosis with deep learning	1
Inorganic polyphosphates stimulates matrix production in human annulus fibrosus cells	1
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	1
Analysis of cell‐free circulating DNA fragment size and level in patients with lumbar canal stenosis	1
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	1