JOR Spine

Article	Citations
	100
Injection Volume Is a Better Predictor of Stiffness Restoration Than Injection Force in an In Vitro Study of Nucleus Augmentation of the Intervertebral Disc	87
Exploring the Biopsychosocial Impact of Chronic Low Back Pain in Workers Through Artificial Intelligence‐Driven Phenotyping	77
Feasibility of Physical Exam and Performance‐Based Tests in Individuals With Chronic Low Back Pain: A Descriptive Study	56
Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study	51
Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease	42
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	36
The effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration	36
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	35
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Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	23
TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model	22
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	22
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	22
Issue Information	19
Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise	18
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy	17
Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?	17
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc	16
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique	16
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells	16
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants	16
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	16
Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs	16
Evaluation of instrumentation and pedicle screw design for posterior lumbar fixation: A pre‐clinical in vivo/ex vivo ovine model	16

Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	15
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	15
Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	15
Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats	14
Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	13
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The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells	13
Issue Information	12
Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype	12
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Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow‐up	12
Clinical implications of linking microstructure, spatial biochemical, spatial biomechanical, and radiological features in ligamentum flavum degeneration	11
Issue Information	11
How to improve the mechanical safety of a novel spinal implant while saving costs and time	11
Deep learning‐based structure segmentation and intramuscular fat annotation on lumbar magnetic resonance imaging	10
Static study and numerical simulation of the influence of cement distribution in the upper and lower adjacent vertebrae on sandwich vertebrae in osteoporotic patients: Finite element analysis	10
Biomedical applications of silk and its role for intervertebral disc repair	10
Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions	10
Correction to “Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs”	9
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	9
Associations between femoral 3D curvature and sagittal imbalance of spine	9
Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks	9
The Cross‐Sectional Areas and Anterior–Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score‐Matched Analysis	9
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs	9
Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor‐Related Gene Analysis	9
Lumbopelvic Kinematics During Functional Tasks in a Chronic Low Back Pain Observational Cohort	9
The Helical Compliance Vector: Utility for Quantifying Spinal Mechanics	9
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	9
Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc	8
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	8
Silibinin promotes healing in spinal cord injury through anti‐ferroptotic mechanisms	8
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	8
Density and mechanical properties of vertebral trabecular bone—A review	8
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	8
Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions	8
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	8
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	8
Analysis of the value of potential biomarker S100‐A8 protein in the diagnosis and pathogenesis of spinal tuberculosis	7
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Enhancing Clinical Insights: New Radiographic Grading for Lumbar Facet Joint Degeneration, A Reliability Study	7
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines	7
Plasma Pro‐ and Anti‐Inflammatory Cytokines in an Observational Chronic Low Back Pain Cohort	7
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	7
Unilateral Lumbo‐Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis	7
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	7
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study	7
Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging‐Based Subject‐Specific Musculoskeletal Models	7
Single‐Side Iatrogenic Pedicle Injury May Trigger an Increased Risk of Contralateral Screw Loosening: An In Silico Study	7
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	7
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Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	7
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network	7
Issue Information	6
Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc	6
Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress‐Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy	6
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	6
Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study	6
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	6
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	6
Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral	6
Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading	6
Enzymatic Behavior of Condoliase in Porcine Nucleus Pulposus: Ex Vivo and In Vitro Assessment	6
Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	5
Comprehensive Evaluation of Facet Joints Osteoarthritis Radiological Features on Lumbar CT: A Multitask Deep Learning Approach	5
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	5
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Socioeconomic status, mental health, and nutrition are the principal traits for low back pain phenotyping: Data from the osteoarthritis initiative	5
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health	5
Characterization and modulation of the pro‐inflammatory effects of immune cells in the canine intervertebral disk	5
Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology	5
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis	5
Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content	4
Transcriptome Data Combined With Mendelian Randomization Analysis Identifies Key Genes Associated With Mitochondria and Programmed Cell Death in Intervertebral Disc Degeneration	4
Threats and opportunities of using ChatGPT in scientific writing—The risk of getting spineless	4
Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration	4
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration	4
Another milestone, accomplished!	4
Intradiscal administration of autologous platelet‐rich plasma in patients with Modic type 1 associated low back pain: A prospective pilot study	4
Neural network segmentation of disc volume from magnetic resonance images and the effect of degeneration and spinal level	4
Demographic and Biomedical Characteristics of an Observational Cohort With Chronic Low Back Pain: A Descriptive Analysis	4
A successful PSRS special issue and Spine across the globe	4
Consolidating and re‐evaluating the human disc nutrient microenvironment	4
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research	4
Facet deflection and strain are dependent on axial compression and distraction in C5–C7 spinal segments under constrained flexion	4
The involvement of immune system in intervertebral disc herniation and degeneration	4
Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, ope	4
DeVa (Decay Variance): A Novel Score Calculated via Postprocessing the Changes in Signal Intensity of an Intervertebral Disc in a T2* Multi‐Echo Magnetic Resonance Image Can Quan	4
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes	4
Pain behavior and phenotype in a modified anterior lumbar disc puncture mouse model	4
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model	4
Reduced Shear Modulus and Altered Lamellar Morphology of the Outer Annulus Fibrosus in Painful Intervertebral Disc Degeneration Compared With Tissue From Non‐Surgical Controls	4
Phosphorylated heat shock protein 27 improves the bone formation ability of osteoblasts and bone marrow stem cells from patients with adolescent idiopathic scoliosis	3
pH: A major player in degenerative intervertebral disks	3
Automatic grading of intervertebral disc degeneration in lumbar dog spines	3
An additively manufactured model for preclinical testing of cervical devices	3
Short‐Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One‐Strike Trigger	3
Inactivation of Tnf‐α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice	3
Spatial and Diurnal Variations in Sodium Content Within Intervertebral Disc Tissue	3
Bioinformatics‐based discovery of intervertebral disc degeneration biomarkers and immune‐inflammatory infiltrates	3
Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue Such as Intervertebral Disc Using QuPath	3
Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective	3
Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion	3
Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways	3
Flexible support material maintains disc height and supports the formation of hydrated tissue engineered intervertebral discs in vivo	3
In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration	3
Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration and Prevents Re‐Herniation	2
Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a Mendelian Randomization Study	2
An exploration of knowledge‐organizing technologies to advance transdisciplinary back pain research	2
Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice	2
Biomolecular therapies for chronic discogenic low back pain: A narrative review	2
The influence of intervertebral disc overloading on nociceptor calcium flickering	2
Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression	2
Transcriptomic profiling reveals key early response genes during GDF6‐mediated differentiation of human adipose‐derived stem cells to nucleus pulposus cells	2
Advancing spinal research beyond COVID‐19	2
Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide	2
Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis	2
Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model	2
E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc	2
A missense GDF5 variant causes brachydactyly type A1 and multiple‐synostoses syndrome 2	2
Harmonization and standardization of nucleus pulposus cell extraction and culture methods	2
Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes	2
Issue Information	2
Advancing basic and preclinical spine research: Highlights from the ORS PSRS 6th International Spine Research Symposium	2
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc	2
The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs	2
Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain	2
High‐Resolution 3‐Dimensional Micro‐CT Imaging of Intervertebral Discs Using a Novel Contrast Agent	2
Welcome to Volume 5!	2
Developmental morphogens direct human induced pluripotent stem cells toward an annulus fibrosus‐like cell phenotype	2
The influence of ligament biomechanics on proximal junctional kyphosis and failure in patients with adult spinal deformity	2

A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells	2
Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model	1
Effects of circulating inflammatory proteins on spinal degenerative diseases: Evidence from genetic correlations and Mendelian randomization study	1
Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc	1
Issue Information	1
Another year over, and a new one is up for highest impact!	1
Injury Induces More Severe Biomechanical Changes in Middle‐Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model	1
Wharton's Jelly Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System	1
Complex In Vivo Motion of the Bovine Tail Provides Unique Insights Into Intervertebral Disc Adaptation	1
Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features	1
Targeting nucleus pulposus cell death in the treatment of intervertebral disc degeneration	1
Issue Information	1
Dynamics of N6‐methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc	1
Automated magnetic resonance imaging‐based grading of the lumbar intervertebral disc and facet joints	1
PHLPP1 deficiency protects against age‐related intervertebral disc degeneration	1
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Influence of macrophage polarization in herniated nucleus pulposus tissue on clinical efficacy after lumbar discectomy	1
Revealing the novel metabolism‐related genes in the ossification of the ligamentum flavum based on whole transcriptomic data	1
DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling	1
Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two‐Step, Two‐Sample Bidirectional Mendelian Randomization Study	1
Range of international surgical strategies for adolescent idiopathic scoliosis: Evaluation of a multi‐center survey	1
The potential effect of romosozumab on perioperative management for instrumentation surgery	1
Sacral anatomical parameters varies in different Roussouly sagittal shapes as well as their relations to lumbopelvic parameters	1
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily	1
Ultrafine‐Grained Materials With Antibacterial Properties: A Novel Approach to Reducing Spinal Implant‐Associated Infections	1
Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear‐Avoidance Beliefs, Insomnia, and Spina	1
Correction to ‘Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization’	1
Development and Validation of a Machine Learning‐Based Online Prognostic Model for Cervical Spondylosis Patients After Anterior Cervical Discectomy and Fusion: A Multicenter Study	1
Development of normalized quantitative measures of lumbar disc degeneration	1
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region	1
Identification and Validation of Circadian Rhythm‐Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning	1
Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes	1
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model	1
Issue Information	1
An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therape	1
Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs	1
Mechanism of Intervertebral Disc Degeneration via the β‐Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice	1
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review	1
A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain	1
Intradiscal injection for the management of low back pain	1
Improving how orthopedic journals report research outcomes based on sex and gender	1
A novel spine tester TO GO	1
Fibrotic and inflammatory characteristics of epidural fat adjacent to the ossification area in patients with ossification of the ligament flavum	1
Issue Information	1
Relationship Between Quantitative MRI and Radiological, Histological, and Biochemical Measures of Intervertebral Disc Health in Client‐Owned, Nonchondrodystrophic‐Breed Dogs	1
Investigation into theanti‐inflammatoryproperties of metformin in intervertebral disc cells	1
Issue Information	1
Assessment of Vertebral Bone Marrow Perfusion, Fat/Water Content, and Trabecular Bone Changes Using Multimodal MRI and Micro‐CT in a Rat Model of Chronic Kidney Disease	1