JOR Spine

Article	Citations
Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression	67
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	61
PHLPP1 deficiency protects against age‐related intervertebral disc degeneration	55
E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc	55
MRI‐based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading	42
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	41
	32
Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	30
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	25
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	24
	24
	20
Inorganic polyphosphates stimulates matrix production in human annulus fibrosus cells	19
	18
Issue Information	18
Experimental confirmation and bioinformatics reveal biomarkers of immune system infiltration and hypertrophy ligamentum flavum	18
Cryopreserving the intact intervertebral disc without compromising viability	16
	15
Hyperosmolar expansion medium improves nucleus pulposus cell phenotype	15
Cervical facet capsular ligament mechanics: Estimations based on subject‐specific anatomy and kinematics	15
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines	14
Influence of macrophage polarization in herniated nucleus pulposus tissue on clinical efficacy after lumbar discectomy	13
Intervertebral disc degeneration and how it leads to low back pain	12
Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders	12
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model	11

Analysis of the value of potential biomarker S100‐A8 protein in the diagnosis and pathogenesis of spinal tuberculosis	11
In vitro coupled motions of the whole human thoracic and lumbar spine with rib cage	11
A fully automatic MRI‐guided decision support system for lumbar disc herniation using machine learning	11
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study	11
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	11
An impactful year for JOR Spine	11
Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading	10
Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	10
The effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration	9
Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease	9
An in vitro 3D annulus fibrosus cell culture model with type I collagen: An examination of cell–matrix interactions	9
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network	9
Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study	8
Scoliosis instrumentation alters primary and coupled motions of the spine: An in vitro study using entire thoracolumbar spine and rib cage specimens	8
Issue Information	8
The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs	7
An exploration of knowledge‐organizing technologies to advance transdisciplinary back pain research	7
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	7
Structure‐function relationships of the human vertebral endplate	7
Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain‐related behavior	7
Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model	6
TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs	6
High throughput computational evaluation of how scaffold architecture, material selection, and loading modality influence the cellular micromechanical environment in tissue engineering strategies	6
Enhancing Clinical Insights: New Radiographic Grading for Lumbar Facet Joint Degeneration, A Reliability Study	6
Development of normalized quantitative measures of lumbar disc degeneration	6
Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice	6
The influence of ligament biomechanics on proximal junctional kyphosis and failure in patients with adult spinal deformity	6
Comparative analysis of paraspinal muscle imbalance between idiopathic scoliosis and congenital scoliosis from the transcriptome aspect	5
TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc	5
Issue Information	5
Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model	5
N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass produc	5
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc	4
L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc	4
Issue Information	4
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health	4
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	4
Dynamics of N6‐methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc	4
Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise	4
Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration	4
Contemporary clinical perspectives on chronic low back pain: The biology, mechanics, etc. underpinning clinical and radiological evaluation	3
Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies	3
Evaluation of the efficacy of modal analysis in predicting the pullout strength of fixation bone screws	3
Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis	3
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy	3
Issue Information	3
	3
	3
Unilateral Lumbo‐Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis	3
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	3

Using embedded alginate microparticles to tune the properties of in situ forming poly(N‐isopropylacrylamide)‐graft‐chondroitin sulfate bioadhesive hydrogels for replacement and repair of the nu	3
Kinematics, kinetics, and new insights from a contemporary analysis of the first experiments to produce cervical facet dislocations in the laboratory	3
Links among MRI features in paraspinal muscles, inflammatory processes, and related back pain in patients with lumbar disc herniation	3
SSR1andCKAP4as potential biomarkers for intervertebral disc degeneration based on integrated bioinformatics analysis	3
A major achievement and a very good news in this first half of 2021!	3
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	3
Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading	3
Issue Information	3
Issue Information	3
Automatic Lenke classification of adolescent idiopathic scoliosis with deep learning	3
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation	3
The role of the complement system in disc degeneration and Modic changes	3
Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?	3
Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a Mendelian Randomization Study	3
In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells	2
Evaluation of lumbar spinal fusion utilizing recombinant human platelet derived growth factor‐B chain homodimer (rhPDGF‐BB) combined with a bovine collagen/β‐tricalcium phosphate (β‐TC	2
A Novel Dynamic Growth Rod Inducing Spinal Growth Modulation for the Correction of Spinal Deformities	2
	2
Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties	2
Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	2
Developmental morphogens direct human induced pluripotent stem cells toward an annulus fibrosus‐like cell phenotype	2
Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide	2
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc	2
Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral	2
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	2
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	2
Fibrotic and inflammatory characteristics of epidural fat adjacent to the ossification area in patients with ossification of the ligament flavum	2
Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes	2
The influence of intervertebral disc overloading on nociceptor calcium flickering	2
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	2
The Relationship Between ADAMTS‐4 and ADAMTS‐5 Enzyme Levels in Patients With Degenerative Disc Disease: A Prospective Biochemical Study	2
A challenging playing field: Identifying the endogenous impediments to annulus fibrosus repair	2
Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia	2
Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model	2
	1
JOR Spine: Reaping the harvest of a community effort	1
A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series	1
Improving how orthopedic journals report research outcomes based on sex and gender	1
Pain behavior and phenotype in a modified anterior lumbar disc puncture mouse model	1
Sacral anatomical parameters varies in different Roussouly sagittal shapes as well as their relations to lumbopelvic parameters	1
Evaluation of instrumentation and pedicle screw design for posterior lumbar fixation: A pre‐clinical in vivo/ex vivo ovine model	1
Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	1
Advancing spinal research beyond COVID‐19	1
Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis	1
Issue Information	1
Species variation in the cartilaginous endplate of the lumbar intervertebral disc	1
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research	1
Consolidating and re‐evaluating the human disc nutrient microenvironment	1
Advancing basic and preclinical spine research: Highlights from the ORS PSRS 6th International Spine Research Symposium	1
	1
A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells	1
A successful PSRS special issue and Spine across the globe	1
	1
2022: A landmark year for JOR Spine	1
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells	1
	1
Influence of patient‐specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls	1
Characterization and modulation of the pro‐inflammatory effects of immune cells in the canine intervertebral disk	1
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	1
Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	1
Integrated DNA methylation analysis reveals a potential role for PTPRN2 in Marfan syndrome scoliosis	1
Transcriptomic profiling reveals key early response genes during GDF6‐mediated differentiation of human adipose‐derived stem cells to nucleus pulposus cells	1
A comprehensive tool box for large animal studies of intervertebral disc degeneration	1
Issue Information	1
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants	1
Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs	1
Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow‐up	0
Issue Information	0
Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc	0
Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research	0
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	0
Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative	0
Nucleus pulposus structure and function assessed in shear using magnetic resonance elastography, quantitative MRI, and rheometry	0
A comprehensive review of cell transplantation and platelet‐rich plasma therapy for the treatment of disc degeneration‐related back and neck pain: A systematic evidence‐based analysis	0
Threats and opportunities of using ChatGPT in scientific writing—The risk of getting spineless	0
Welcome to Volume 5!	0
A missense GDF5 variant causes brachydactyly type A1 and multiple‐synostoses syndrome 2	0
Issue Information	0
Socioeconomic status, mental health, and nutrition are the principal traits for low back pain phenotyping: Data from the osteoarthritis initiative	0
Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences	0

An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therape	0
Distinct clinical characteristics of adolescent idiopathic scoliosis with asymmetrical ESR1 expression in paraspinal muscle progenitor cells	0
@JORSPine	0
Assessment of Vertebral Bone Marrow Perfusion, Fat/Water Content, and Trabecular Bone Changes Using Multimodal MRI and Micro‐CT in a Rat Model of Chronic Kidney Disease	0
An in vitro comparison of three nucleus pulposus removal techniques for partial intervertebral disc replacement: An ultra‐high resolution MRI study	0
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	0
Flexible support material maintains disc height and supports the formation of hydrated tissue engineered intervertebral discs in vivo	0
Inactivation of Tnf‐α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice	0
Neural network segmentation of disc volume from magnetic resonance images and the effect of degeneration and spinal level	0
Silibinin promotes healing in spinal cord injury through anti‐ferroptotic mechanisms	0
Facet joint degeneration—An initial procedure of the cervical spine degeneration	0
Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes	0
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	0
Issue Information	0
Density and mechanical properties of vertebral trabecular bone—A review	0
No evidence of association between either Modic change or disc degeneration and five circulating inflammatory proteins	0
Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture	0
pH: A major player in degenerative intervertebral disks	0
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model	0
Posterior Ligamentum Complex Preservation Alleviate ASD‐Related Biomechanical Deterioration in Lumbar Interbody Fusion Models: A Finite Element Analysis	0
The involvement of immune system in intervertebral disc herniation and degeneration	0
Issue Information	0
Range of international surgical strategies for adolescent idiopathic scoliosis: Evaluation of a multi‐center survey	0
Investigating the causal links between inflammatory cytokines and scoliosis through bidirectional Mendelian randomization analysis	0
Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain	0
Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion	0
Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features	0
Low‐Frequency Cyclic Stretch Upregulates the Expression of Nuclear Factor Erythroid 2‐Related Factor 2 in Human Nucleus Pulposus Cells to Inhibit the Resistin‐Induced Interleukin‐20 Expression	0
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis	0
Another year over, and a new one is up for highest impact!	0
Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, ope	0
Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury	0
Issue Information	0
Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix	0
Associations between femoral 3D curvature and sagittal imbalance of spine	0
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review	0
Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORSspine section	0
Single‐level cervical disc arthroplasty in the spine with reversible kyphosis: A finite element study	0
The genetic causal association between arthritis and low back pain	0
Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment	0
Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity	0
Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration	0
Three‐dimensional fiber patterning in the annulus fibrosus can be derived from vertebral endplate topography	0
Correction to “Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs”	0
Intradiscal administration of autologous platelet‐rich plasma in patients with Modic type 1 associated low back pain: A prospective pilot study	0
Revealing the novel metabolism‐related genes in the ossification of the ligamentum flavum based on whole transcriptomic data	0
Investigation of in vivo three‐dimensional changes of the spinal canal after corrective surgeries of the idiopathic scoliosis	0
Preliminary investigation of spinal level and postural effects on thoracic muscle morphology with upright openMRI	0
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	0
	0
Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates	0
Preclinical models of vertebral osteomyelitis and associated infections: Current models and recommendations for study design	0
Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype	0
Effect of voluntary running activity on mRNA expression of extracellular matrix genes in a mouse model of intervertebral disc degeneration	0
Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells	0
	0
Intradiscal injection for the management of low back pain	0
Construction of circ_0071922‐miR‐15a‐5p‐mRNA network in intervertebral disc degeneration by RNA‐sequencing	0
Another milestone, accomplished!	0
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	0
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	0
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration	0
Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration	0
A novel spine tester TO GO	0
DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling	0
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes	0
Analysis of intervertebral disc CCR6 and IL‐6 gene levels with short‐term postoperative low back pain after spinal fusion in lumbar degenerative disease	0
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	0
Cell sources proposed for nucleus pulposus regeneration	0
The potential effect of romosozumab on perioperative management for instrumentation surgery	0
Harmonization and standardization of nucleus pulposus cell extraction and culture methods	0
An additively manufactured model for preclinical testing of cervical devices	0
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells	0
Advances in basic and preclinical spine research: Highlights from the Chinese Spine Research Community	0
Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low‐biomass microbiome analysis	0
Protective effects of curcumin against spinal cord injury	0
Analysis of cell‐free circulating DNA fragment size and level in patients with lumbar canal stenosis	0
In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration	0
Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content	0
Biomolecular therapies for chronic discogenic low back pain: A narrative review	0
The Cross‐Sectional Areas and Anterior–Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score‐Matched Analysis	0
IL‐1Ra deficiency accelerates intervertebral disc degeneration in C57BL6J mice	0
Deep learning‐based structure segmentation and intramuscular fat annotation on lumbar magnetic resonance imaging	0
Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization	0
	0
Phosphorylated heat shock protein 27 improves the bone formation ability of osteoblasts and bone marrow stem cells from patients with adolescent idiopathic scoliosis	0
Issue Information	0
Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section	0
Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions	0
Automatic detection and voxel‐wise mapping of lumbar spine Modic changes with deep learning	0
Optimal intermittent administration interval of parathyroid hormone 1‐34 for bone morphogenetic protein‐induced bone formation in a rat spinal fusion model	0
Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study	0
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region	0
Thresholding approaches for estimating paraspinal muscle fat infiltration using T1‐ and T2‐weighted MRI: Comparative analysis using water–fat MRI	0
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily	0