OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Communications is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Global patterns of breast cancer incidence and mortality: A population‐based cancer registry data analysis from 2000 to 2020	513
Cancer incidence, mortality, and burden in China: a time‐trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020	475
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021	378
Ferroptosis in cancer and cancer immunotherapy	276
Non‐small cell lung cancer in China	213
EMT‐associated microRNAs and their roles in cancer stemness and drug resistance	187
The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma	177
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review	142
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy	136
A global assessment of recent trends in gastrointestinal cancer and lifestyle‐associated risk factors	128
Breast cancer: an up‐to‐date review and future perspectives	126
The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer	126
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer	121
Advancing to the era of cancer immunotherapy	99
Artificial intelligence for assisting cancer diagnosis and treatment in the era of precision medicine	99
Efficacy and safety of a novel anti‐HER2 therapeutic antibody RC48 in patients with HER2‐overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single‐arm phase	97
Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression	92
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma	89
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities	86
Neoadjuvant immunotherapy for non–small cell lung cancer: State of the art	81
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	79
Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy	75
Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first‐line treatment of advanced esophageal squamous cell carcinoma	74
The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential	72
Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy	67

New insights into molecules and pathways of cancer metabolism and therapeutic implications	66
An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment	65
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy	65
N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA	62
The Fibrillin‐1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells	59
Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa‐miR‐6887‐3p	57
Tumor microenvironment signaling and therapeutics in cancer progression	57
The theory of tumor ecosystem	56
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells	56
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities	53
Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration?	52
HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program	50
S100A8 promotes epithelial‐mesenchymal transition and metastasis under TGF‐β/USF2 axis in colorectal cancer	49
Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study	49
Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1	49
Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib	45
KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer	44
Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates	44
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges	42
Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma	40
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling	40
Elevated neutrophil extracellular traps by HBV‐mediated S100A9‐TLR4/RAGE‐ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma	39
Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma	39
Lipid metabolism in pancreatic cancer: emerging roles and potential targets	39
Molecular subtyping of hepatocellular carcinoma: A step toward precision medicine	38
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism	36
Resistance to antibody‐drug conjugates in breast cancer: mechanisms and solutions	36
METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression	35
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis	35
Anti‐PD‐L1/TGF‐βR fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer	34
Tumor heterogeneity and the potential role of liquid biopsy in bladder cancer	34
Programmed death ligand‐1 regulates angiogenesis and metastasis by participating in the c‐JUN/VEGFR2 signaling axis in ovarian cancer	34
Estrogen receptor‐low breast cancer: Biology chaos and treatment paradox	32
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large‐scale cohort study in China	31
Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma	31
Atezolizumab plus bevacizumab versus sorafenib as first‐line treatment for unresectable hepatocellular carcinoma: a cost‐effectiveness analysis	29
The EGFR‐P38 MAPK axis up‐regulates PD‐L1 through miR‐675‐5p and down‐regulates HLA‐ABC via hexokinase‐2 in hepatocellular carcinoma cells	29
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first‐line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, r	27
N⁶‐methyladenosine Steers RNA Metabolism and Regulation in Cancer	27
Predictions of mortality related to four major cancers in China, 2020 to 2030	26
Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β₂‐AR/MACC1 axis	26
m⁶A‐mediated regulation of PBX1‐GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels	26
CRISPR/Cas9 screening identifies a kinetochore‐microtubule dependent mechanism for Aurora‐A inhibitor resistance in breast cancer	26
KDELR2 promotes breast cancer proliferation via HDAC3‐mediated cell cycle progression	26
Antibody variable region engineering for improving cancer immunotherapy	25
Phosphatidylserine released from apoptotic cells in tumor induces M2‐like macrophage polarization through the PSR‐STAT3‐JMJD3 axis	25
Nuclear Aurora kinase A triggers programmed death‐ligand 1‐mediated immune suppression by activating MYC transcription in triple‐negative breast cancer	25
Metabolic regulation in the immune response to cancer	25
Harness the functions of gut microbiome in tumorigenesis for cancer treatment	24
Crosstalk between IL‐15Rα⁺tumor‐associated macrophages and breast cancer cells reduces CD8⁺T cell recruitment	24

Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma	23
Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients	23
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis	23
Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2‐positive gastric cancer	22
RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment	22
Sintilimab versus docetaxel as second‐line treatment in advanced or metastatic squamous non‐small‐cell lung cancer: an open‐label, randomized controlled phase 3 trial (ORIENT‐3)	22
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer	22
A non‐metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11‐mediated CD133 stability	21
LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex‐mediated changes in chromatin structure in lung adenocarcinoma	21
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023	21
Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management	20
Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells	20
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer	20
The role of myeloid‐derived suppressor cells in gastrointestinal cancer	19
YB1 regulates miR‐205/200b‐ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma	19
The crosstalk between ferroptosis and anti‐tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy	19
Liquid biopsy for esophageal cancer: Is detection of circulating cell‐free DNA as a biomarker feasible?	18
Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer	18
N6‐methyladenosine‐modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis‐regulated Hippo pathway	18
Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21‐mediated ubiquitination/degradation of STAT1 in a GTP binding‐dependent modality	18
Epi‐immunotherapy for cancers: rationales of epi‐drugs in combination with immunotherapy and advances in clinical trials	18
Retreatment in locally recurrent nasopharyngeal carcinoma: Current status and perspectives	18
Safety, tolerability, and pharmacokinetics of BAT8001 in patients with HER2‐positive breast cancer: An open‐label, dose‐escalation, phase I study	18
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4	18
Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy	18
The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non‐small cell lung cancer patients with epidermal growth factor receptor mutation	18
XELOX doublet regimen versus EOX triplet regimen as first‐line treatment for advanced gastric cancer: An open‐labeled, multicenter, randomized, prospective phase III trial (EXELOX)	17
Infection complications in febrile chimeric antigen receptor (CAR)‐T recipients during the peri‐CAR‐T cell treatment period examined using metagenomic next‐generation sequencing (mNGS)	17
Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges	17
P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer	17
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c‐Myc‐mediated positive feedback loop	17
CD70‐targeting CAR‐T cells have potential activity against CD19‐negative B‐cell Lymphoma	16
MAGE‐C3 promotes cancer metastasis by inducing epithelial‐mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma	16
Favorable response to immunotherapy in a pancreatic neuroendocrine tumor with temozolomide‐induced high tumor mutational burden	16
Abscopal effect of stereotactic radiotherapy combined with anti‐PD‐1/PD‐L1 immunotherapy: Mechanisms, clinical efficacy, and issues	15
The establishment of polypeptide PSMA‐targeted chimeric antigen receptor‐engineered natural killer cells for castration‐resistant prostate cancer and the induction of ferroptosis‐related cell death	15
Targeting RAS mutants in malignancies: successes, failures, and reasons for hope	15
The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy	15
Roles and implications of mRNA N⁶‐methyladenosine in cancer	14
Detection of pancreatic cancer by indocyanine green‐assisted fluorescence imaging in the first and second near‐infrared windows	14
Dicer‐independent snRNA/snoRNA‐derived nuclear RNA 3 regulates tumor‐associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription	14
Childhood overweight and risk of obesity‐related adult cancer in men	14
Bevacizumab biosimilar LY01008 compared with bevacizumab (Avastin) as first‐line treatment for Chinese patients with unresectable, metastatic, or recurrent non‐squamous non–small‐cell lung cancer: A m	14
Outcomes in refractory diffuse large B‐cell lymphoma: results from a multicenter real‐world study in China	14
BAALC‐AS1/G3BP2/c‐Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma	13
Phase III trial of docetaxel cisplatin 5‐fluorouracil induction chemotherapy for resectable oral cancer suggests favorable pathological response as a surrogate endpoint for good therapeutic outcome	13
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82	13
Enhancement of CAR‐T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins	13
Activity and bioavailability of tepotinib for leptomeningeal metastasis of NSCLC with MET exon 14 skipping mutation	13
Macrophage inhibitory cytokine‐1 induced by a high‐fat diet promotes prostate cancer progression by stimulating tumor‐promoting cytokine production from tumor stromal cells	13
Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract	12
Impact of diabetes on promoting the growth of breast cancer	12
Involvement of long non‐coding RNAs in the progression of esophageal cancer	12
Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors	12
Bifidobacterium adolescentis orchestrates CD143⁺ cancer‐associated fibroblasts to suppress colorectal tumorigenesis by Wnt signaling‐regulated GAS1	12
PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity	12
PDGFA‐associated protein 1 is a novel target of c‐Myc and contributes to colorectal cancer initiation and progression	12
The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression	11
RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells	11
Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non‐small‐cell lung cancer characterizes the features of response to PD‐1 blockade plus chemotherapy	11
miR‐99a‐5p modulates doxorubicin resistance via the COX‐2/ABCG2 axis in triple‐negative breast cancer: from the discovery to in vivo studies	11
Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15‐year follow‐up study	11
Improved esophageal squamous cell carcinoma screening effectiveness by risk‐stratified endoscopic screening: evidence from high‐risk areas in China	11
Age‐specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross‐sectional study	11