OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Communications is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Kindlin‐1 drives early steps of breast cancer metastasis	563
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Treatment of Metastatic Cancer by Conferring Immunogenicity to the Apoptotic Bodies of the Primary Tumor	284
Single‐cell transcriptomics and epigenomics point to CD58‐CD2 interaction in controlling primary melanoma growth and immunity	272
Correction to “Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges”	254
Nine‐fold variation of risk of advanced colorectal neoplasms according to smoking and polygenic risk score: Results from a cross‐sectional study in a large screening colonoscopy cohort	233
Issue Information	211
Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation	207
Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin‐bundling activity and tumor metastasis in esophageal squamous cell carcinoma	165
Issue Information	159
Issue Information	158
Defining and tracing subtypes of patient‐derived xenograft models in pancreatic ductal adenocarcinoma	149
Combined local therapy and CAR‐GPC3 T‐cell therapy in advanced hepatocellular carcinoma: a proof‐of‐concept treatment strategy	146
Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study	144
Dysregulated proline metabolism exacerbates HCC metastasis via EPRS1-mediated mRNA translation	141
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update	133
Current status and perspectives of esophageal cancer: a comprehensive review	131
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	127
Validation of different personalized risk models of chemotherapy‐induced nausea and vomiting: results of a randomized, double‐blind, phase III trial of fosaprepitant for cancer patients treated with h	122
Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial	113
Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer	111
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Oral transforming growth factor‐beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti‐tumor immunity	95

EXPRESSION OF CONCERN: Discovery of a Novel Viroid‐Like Circular RNA in Colorectal Cancer	94
Comparative single‐cell analysis of esophageal cancer subtypes reveals tumor microenvironment distinctions explaining varied immunotherapy responses	94
Partial hepatectomy versus interventional treatment in patients with hepatitis B virus‐related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinica	93
Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of	78
Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study	69
Issue Information	67
Development and validation of an artificial intelligence model for predicting post‐transplant hepatocellular cancer recurrence	67
Nasopharyngeal carcinoma treatment paradigm after HK0501 – a potential way forward	65
Single‐cell transcriptomics provides insights into the origin and immune microenvironment of cervical precancerous lesions	65
p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases	65
A nanotherapeutic strategy to target drug‐tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer	64
Issue Information	61
N ⁶ ‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastas	60
First‐line serplulimab plus chemotherapy in extensive‐stage small‐cell lung cancer: Updated results and biomarker analysis from the ASTRUM‐005 randomized clinical trial	60
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer	60
Targeting IL‐17A to manage immunotherapy‐induced toxicity in melanoma	59
FOXO1 or not FOXO1: that is the question	59
A strong internal promoter drives massive expression of YEATS‐domain devoid MLLT3 transcripts in HSC and most lethal AML	58
Acquired RD3 loss regulates immune surveillance in high‐risk and therapy defying progressive neuroblastoma	57
Association of previously irradiated stable brain metastases with outcomes of atezolizumab‐treated non‐small cell lung cancer: A pooled analysis of individual patient data from three randomized trials	56
Cover Image, Volume 45, Issue 6	56
Issue Information	54
Impact of small molecule‐mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism	53
Antitumoral effects of cannabis in Notch1 ‐mutated T‐cell acute lymphoblastic leukemia	53
Ubiquitination in cancer: mechanisms and therapeutic opportunities	53
Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene	51
Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation	50
First-Line Tislelizumab Combined with Bevacizumab and CAPOX for Metastatic Gastroesophageal Adenocarcinoma with Low Programmed Death-Ligand 1 Expression	49
Harnessing chimeric antigen receptor macrophages against solid tumors	49
Incidence of and survival with bone and soft tissue sarcoma: A nation‐wide study over four decades	47
m ⁶ A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma	46
Enhanced selection of people for lung cancer screening using AHRR (cg05575921) or F2RL3 (cg03636183) methy	46
Transcriptomic analyses of localized prostate cancers of East Asian and North American men reveal race‐specific luminal‐basal and microenvironmental differences	45
Correction to “Circulating tumor cells share RNA modules with early embryo trophectoderm and with metastatic cancer”	45
Low household income and income volatility increase risk of lung cancer: A nationwide retrospective cohort study	44
Issue Information	43
Development of antibody‐drug conjugates in cancer: Overview and prospects	41
An HGF‐dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis	41
4‐1BB transcriptomic expression patterns across malignancies: Implications for clinical trials of 4‐1BB agonists	40
Breast cancer: an up‐to‐date review and future perspectives	40
Inhibition of mTOR attenuates the initiation and progression of BRCA1 ‐associated mammary tumors	39
Vebreltinib for Previously Treated Astrocytoma, IDH -Mutant, Grade 4, and Glioblastoma, IDH Wild-Type with	39
Neuroinflammation drives apathy in cancer cachexia	39
Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract	38
Genomic information of children with malignant brain tumors for the prediction of length of hospitalization	38
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer	38
Long‐term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants	38
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy	37
Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients	37
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N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA	36
Issue Information	36
Knowing nodal Rouviére: the power of human intelligence in toxicity reduction	35
Single‐cell and bulk transcriptomics identifies a tumor‐specific CD36 ⁺ cancer‐associated fibroblast subpopulation in colorectal cancer	35
Combination of photodynamic therapy and stimulator of interferon genes (STING) agonist inhibits colorectal tumor growth and recurrence	35
Cover Image, Volume 44, Issue 4	35
Issue Information	35
Pancreatic cancer survival trends in the US from 2001 to 2014: a CONCORD‐3 study	34
Sunitinib in metastatic renal cell carcinoma: clinical outcomes across risk groups in a Turkish Oncology Group Kidney Cancer Consortium	34
Issue Information	34
Enhancement of CAR‐T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins	32
Breaking barriers: Smart vaccine platforms for cancer immunomodulation	32
Preoperative Chemoradiotherapy versus Chemotherapy for Locally Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma: A Phase III Randomized Controlled Trial from China	32
DNA methylation signature predicts cancer response to demethylation agents from profiling diverse cancer cell lines	31
Galectin 3‐binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor‐β1 (TGF‐β1) availability and inhibits hepatocarcinogenesis	30
Tumor microenvironment signaling and therapeutics in cancer progression	30
Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms	30
Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy	30
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3	29
The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression	29
Harnessing the Power of CAR-NK Cells for Solid Tumors: Challenges, Innovations, and Future Frontiers in Immunotherapy	29
The Ly6g ^high Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8 ⁺ T Cell Death	29
Targeting ferroptosis resistance resensitizes metastatic HR ⁺ HER2 ⁻ breast cancer cells to palboc	28
Issue Information	27
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TOPK Suppresses the CD8 ⁺ T Cell Antitumor Immunity via Modulation of IRF5 Expression	26
Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors	25
A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment	24
Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy	24
Camrelizumab Plus Nab-paclitaxel in Patients with Previously Treated Advanced Urothelial Carcinoma: A Multicenter Phase II Study	23
Single‐cell‐eQTL mapping in circulating immune cells reveals genetic regulation of response‐associated networks in lung cancer immunotherapy	23
Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer	23
Cover Image, Volume 43, Issue 6	23
Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti‐PD‐1 therapy	23
The regulatory roles and clinical significance of glycolysis in tumor	22
Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation	22
Tumor‐derived insulin‐like growth factor‐binding protein‐1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors	22
In vivo intratumoral heterogeneity in a dish: scalable forebrain organoid models of embryonal brain tumors for high‐throughput personalized drug discovery	21
HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism	21
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Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China	20
Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes in the Mouse Endometrium Recapitulates High-Risk Endometrial Carcinoma	20
Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors	20
Single‐cell atlas reveals a distinct immune profile fostered by T cell‐B cell crosstalk in triple negative breast cancer	20
Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis	20
TIMELESS Promotes LUAD Growth via Suppressing Transferrin-Mediated Ferroptosis and Reprograms the Tumor Microenvironment against Anti-PD-1 Immunotherapy	19
The SARS‐CoV‐2 spike protein induces lung cancer migration and invasion in a TLR2‐dependent manner	19
Concurrent chemoradiotherapyof different radiation doses and different irradiation fields for locally advanced thoracic esophageal squamous cell carcinoma: A randomized, multicenter, phase III clinica	19
Safety and immunogenicity of a third dose of mRNA‐1273 vaccine among cancer patients	19
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma	18
NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma	18
RNA m ¹ A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stabil	18
Transient and DNA‐free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis	17
Issue Information	17
Targeted STAT1 therapy for LZTR1‐driven peripheral nerve sheath tumor	17
Diagnostic value of genetic mutation analysis and mutation profiling of cell‐free DNA in intraocular fluid for vitreoretinal lymphoma	17
Efficacy, safety and biomarkers of SG001 for patients with previously treated recurrent or metastatic cervical cancer: an open‐label, multicenter, phase Ib trial	17
Discovery of a novel viroid‐like circular RNA in colorectal cancer	17