OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Communications is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses	575
	535
Issue Information	397
Loss of SMARCB1 evokes targetable epigenetic vulnerabilities in epithelioid sarcoma	326
Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti‐PD‐1 therapy	263
Issue Information	191
Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling	153
Cover Image, Volume 41, Issue 12	152
A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy	151
Cover Image, Volume 43, Issue 6	148
Issue Information	147
	121
The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non‐small cell lung cancer patients with epidermal growth factor receptor mutation	113
Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors	103
	100
Issue Information	99
Vitamin D₃ for reducing mortality from cancer and other outcomes before, during and beyond the COVID‐19 pandemic: A plea for harvesting low‐hanging fruit	92
Pre‐transplantation cytoreduction does not benefit advanced myelodysplastic syndrome patients after myeloablative transplantation with grafts from family donors	89
Issue Information	85
Issue Information	81
Cover Image, Volume 42, Issue 6	80
Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin‐bundling activity and tumor metastasis in esophageal squamous cell carcinoma	80
A serum microRNA signature for enhanced selection of people for lung cancer screening	78
Interleukin‐10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath	76
Kindlin‐1 drives early steps of breast cancer metastasis	76

Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation	73
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Cover Image, Volume 42, Issue 8	65
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Age‐specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross‐sectional study	59
An integrated genetic‐epigenetic analysis shed light on the mechanisms linking coronavirus disease 2019 (COVID‐19) and cancer	58
Issue Information	57
AP4 induces JNK1 and a miR‐22‐3p/FOSL1 feed‐forward loop to activate AP‐1 and promote colorectal cancer metastasis	54
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Cover Image, Volume 43, Issue 11	54
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer	53
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Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib‐refractory ALK‐positive NSCLC from a phase II study	50
Revealing the secret behind Epstein‐Barr virus‐specific tumor immune contexture	49
Disclosing the true impact of screening endoscopy in colorectal cancer prevention	47
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Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations	44
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy	44
Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non‐small cell lung cancer patients with brain metastasis	42
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges	42
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3	41
Issue Information	40
A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment	40
Survival impact of early MRI progression after stereotactic radiotherapy for brain metastases	36
	36
Radiotherapy‐resistant prostate cancer cells escape immune checkpoint blockade through the senescence‐related ataxia telangiectasia and Rad3‐related protein	35
Nine‐fold variation of risk of advanced colorectal neoplasms according to smoking and polygenic risk score: Results from a cross‐sectional study in a large screening colonoscopy cohort	34
Issue Information	33
Targeting the LMP1‐ALIX axis in EBV⁺ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity	32
Unveiling quality of clinical trial in China: from concern to confirmation	31
Current status and perspectives of esophageal cancer: a comprehensive review	31
The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells	28
Worldwide trends in esophageal cancer survival, by sub‐site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000‐2014 (CONCORD‐3)	28
Defining and tracing subtypes of patient‐derived xenograft models in pancreatic ductal adenocarcinoma	27
Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer	27
Combined local therapy and CAR‐GPC3 T‐cell therapy in advanced hepatocellular carcinoma: a proof‐of‐concept treatment strategy	27
Metabolic regulation in the immune response to cancer	26
Two distinct stem cell‐like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials	26
Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study	26
Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study	26
Spatial relationship of tertiary lymphoid structures and tumor‐associated neutrophils in bladder cancer and prognostic potential for anti‐PD‐L1 immunotherapy	26
Childhood overweight and risk of obesity‐related adult cancer in men	25
Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma	25
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma	25
Immune mediated support of metastasis: Implication for bone invasion	25
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism	25
Lipid metabolism in pancreatic cancer: emerging roles and potential targets	24
Crosstalk between IL‐15Rα⁺tumor‐associated macrophages and breast cancer cells reduces CD8⁺T cell recruitment	23
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first‐line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, r	23
Survival trends of patients with non‐metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates	22

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update	22
Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy	22
Criteria and regulatory considerations for the conditional approval of innovative antitumor drugs in China: from the perspective of clinical reviewers	22
Detection of pancreatic cancer by indocyanine green‐assisted fluorescence imaging in the first and second near‐infrared windows	20
Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer: a post hoc ana	20
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	19
Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma	19
Converting “cold” to “hot”: epigenetics strategies to improve immune therapy effect by regulating tumor‐associated immune suppressive cells	18
Targeting ferroptosis resistance resensitizes metastatic HR⁺HER2⁻ breast cancer cells to palbociclib‐hormone therapy	18
Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1	18
	18
Single‐cell transcriptomics and epigenomics point to CD58‐CD2 interaction in controlling primary melanoma growth and immunity	18
Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study	18
SYNCRIP promotes cell cycle progression and lung tumorigenesis by modulating AURKB translation	18
The regulatory roles and clinical significance of glycolysis in tumor	18
Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib	18
Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer	17
Bioequivalence of alternative pembrolizumab dosing regimens: current practice and future perspectives	17
Anti‐tumor drug supervision in China from 2010 to 2024: the evolution and prospect of drug review standards	17
Circulating tumor cells share RNA modules with early embryo trophectoderm and with metastatic cancer	17
Single‐cell transcriptomics provides insights into the origin and immune microenvironment of cervical precancerous lesions	16
Outcomes and toxicities of immune checkpoint inhibitors in colorectal cancer: a real‐world retrospective analysis	16
Issue Information	16
Validation of different personalized risk models of chemotherapy‐induced nausea and vomiting: results of a randomized, double‐blind, phase III trial of fosaprepitant for cancer patients treated with h	15
Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China	15
Social‐epigenetic mediators for racial disparities in pulmonary impairment among childhood cancer survivors	15
Issue Information	15
Issue Information	14
Cover Image, Volume 42, Issue 4	14
	14
Issue Information	14
Non‐recovery of renal function was correlated with increased mortality in the cancer cohort with septic shock	14
The repertoire of germline variants in patients with early‐onset rectal cancer	14
HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program	14
Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma	13
Research trends of cancer metabolism: analysis from a Chinese perspective	13
Retreatment in locally recurrent nasopharyngeal carcinoma: Current status and perspectives	13
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy	13
The interplay between natural killer cells and pancreatic stellate cells in pancreatic ductal adenocarcinoma	13
Cover Image, Volume 42, Issue 5	13
Issue Information	12
	12
Dietary long‐chain fatty acid metabolism boosts antitumor immune response	12
Nasopharyngeal carcinoma treatment paradigm after HK0501 – a potential way forward	12
	12
Establishment of an orthotopic perirenal space xenograft mouse model of retroperitoneal sarcoma	12
Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec‐15 axis in immune escape	12
Issue Information	12
Cover Image, Volume 44, Issue 6	12
Issue Information	12
Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors	11
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells	11
Tumor‐derived insulin‐like growth factor‐binding protein‐1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors	11
	11
Single‐cell atlas reveals a distinct immune profile fostered by T cell‐B cell crosstalk in triple negative breast cancer	11
	11
	11
Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study	11
Efficacy and safety of KN026 and docetaxel for HER2‐positive breast cancer: a phase II clinical trial	10
p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases	10
Partial hepatectomy versus interventional treatment in patients with hepatitis B virus‐related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinica	10
Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy	9
Parkin deficiency promotes colorectal tumorigenesis and progression through RIPK3‐dependent necroptotic inflammation	9
Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial	9
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82	9
Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β₂‐AR/MACC1 axis	8
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer	8
MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria‐dependent dephosphorylation of EGFR	8
Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates	8
Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized controlled trial	8
A phase Ib/II study of fruquintinib in combination with paclitaxel as the second‐line therapy for advanced gastric cancer	8
N6‐methyladenosine‐modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis‐regulated Hippo pathway	8
Detection of piRNA‐54265 in human serum: evidence and significance	8
Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy	8