OOIR: Observatory of International Research

Papers

(The median citation count of Cancer Communications is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses	653
	601
Issue Information	441
Loss of SMARCB1 evokes targetable epigenetic vulnerabilities in epithelioid sarcoma	386
Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti‐PD‐1 therapy	323
Issue Information	229
Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling	200
SYNCRIP promotes cell cycle progression and lung tumorigenesis by modulating AURKB translation	194
Issue Information	184
Worldwide trends in esophageal cancer survival, by sub‐site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000‐2014 (CONCORD‐3)	178
Cover Image, Volume 41, Issue 12	165
A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy	160
Issue Information	140
Issue Information	139
Cover Image, Volume 42, Issue 6	125
Cover Image, Volume 43, Issue 6	123
Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin‐bundling activity and tumor metastasis in esophageal squamous cell carcinoma	123
Issue Information	113
	112
Single‐cell transcriptomics and epigenomics point to CD58‐CD2 interaction in controlling primary melanoma growth and immunity	111
Bioequivalence of alternative pembrolizumab dosing regimens: current practice and future perspectives	110
Circulating tumor cells share RNA modules with early embryo trophectoderm and with metastatic cancer	106
Anti‐tumor drug supervision in China from 2010 to 2024: the evolution and prospect of drug review standards	92
Cover Image, Volume 43, Issue 11	90
	85

The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non‐small cell lung cancer patients with epidermal growth factor receptor mutation	84
	82
Issue Information	81
Vitamin D₃ for reducing mortality from cancer and other outcomes before, during and beyond the COVID‐19 pandemic: A plea for harvesting low‐hanging fruit	80
Two distinct stem cell‐like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials	75
Spatial relationship of tertiary lymphoid structures and tumor‐associated neutrophils in bladder cancer and prognostic potential for anti‐PD‐L1 immunotherapy	74
Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study	74
Metabolic regulation in the immune response to cancer	73
A serum microRNA signature for enhanced selection of people for lung cancer screening	69
	67
Interleukin‐10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath	65
Kindlin‐1 drives early steps of breast cancer metastasis	63
	61
Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation	61
Cover Image, Volume 42, Issue 8	60
Age‐specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross‐sectional study	59
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Issue Information	58
AP4 induces JNK1 and a miR‐22‐3p/FOSL1 feed‐forward loop to activate AP‐1 and promote colorectal cancer metastasis	57
Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib‐refractory ALK‐positive NSCLC from a phase II study	52
Targeting ferroptosis resistance resensitizes metastatic HR⁺HER2⁻ breast cancer cells to palbociclib‐hormone therapy	52
Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1	52
Disclosing the true impact of screening endoscopy in colorectal cancer prevention	50
Revealing the secret behind Epstein‐Barr virus‐specific tumor immune contexture	50
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy	48
	48
Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations	45
A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment	39
Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non‐small cell lung cancer patients with brain metastasis	39
Issue Information	39
Nine‐fold variation of risk of advanced colorectal neoplasms according to smoking and polygenic risk score: Results from a cross‐sectional study in a large screening colonoscopy cohort	37
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Issue Information	35
Targeting the LMP1‐ALIX axis in EBV⁺ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity	35
Unveiling quality of clinical trial in China: from concern to confirmation	34
Survival trends of patients with non‐metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates	34
Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study	33
Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer	33
Combined local therapy and CAR‐GPC3 T‐cell therapy in advanced hepatocellular carcinoma: a proof‐of‐concept treatment strategy	33
The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells	33
Defining and tracing subtypes of patient‐derived xenograft models in pancreatic ductal adenocarcinoma	33
Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy	32
Childhood overweight and risk of obesity‐related adult cancer in men	32
Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer: a post hoc ana	31
	28
Immune mediated support of metastasis: Implication for bone invasion	27
Converting “cold” to “hot”: epigenetics strategies to improve immune therapy effect by regulating tumor‐associated immune suppressive cells	27
Detection of pancreatic cancer by indocyanine green‐assisted fluorescence imaging in the first and second near‐infrared windows	27
Whole‐genome CRISPR‐Cas9 knockout screens identify SHOC2 as a genetic dependency in NRAS‐mutant melanoma	26
Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma	26

Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma	25
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges	25
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first‐line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, r	25
The regulatory roles and clinical significance of glycolysis in tumor	25
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3	25
Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors	25
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer	24
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism	24
Criteria and regulatory considerations for the conditional approval of innovative antitumor drugs in China: from the perspective of clinical reviewers	23
Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study	23
Lipid metabolism in pancreatic cancer: emerging roles and potential targets	23
Survival impact of early MRI progression after stereotactic radiotherapy for brain metastases	22
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	22
Current status and perspectives of esophageal cancer: a comprehensive review	22
Radiotherapy‐resistant prostate cancer cells escape immune checkpoint blockade through the senescence‐related ataxia telangiectasia and Rad3‐related protein	22
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update	22
Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib	21
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma	21
Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China	20
Single‐cell transcriptomics provides insights into the origin and immune microenvironment of cervical precancerous lesions	20
Issue Information	20
Crosstalk between IL‐15Rα⁺tumor‐associated macrophages and breast cancer cells reduces CD8⁺T cell recruitment	20
Issue Information	20
Issue Information	19
Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma	19
The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential	19
A nanotherapeutic strategy to target drug‐tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer	19
Phospholipase iPLA2β acts as a guardian against ferroptosis	19
Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers	18
The interplay between natural killer cells and pancreatic stellate cells in pancreatic ductal adenocarcinoma	18
Development and validation of an artificial intelligence model for predicting post‐transplant hepatocellular cancer recurrence	17
Social‐epigenetic mediators for racial disparities in pulmonary impairment among childhood cancer survivors	17
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Issue Information	17
Research trends of cancer metabolism: analysis from a Chinese perspective	16
Cover Image, Volume 42, Issue 4	16
Non‐recovery of renal function was correlated with increased mortality in the cancer cohort with septic shock	16
Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells	15
Intra‐heterogeneity in transcription and chemoresistant property of leukemia‐initiating cells in murine Setd2^−/− acute myeloid leukemia	15
Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy	15
Cover Image, Volume 42, Issue 5	15
Matrisomal genes in squamous cell carcinoma of head and neck influence tumor cell motility and response to cetuximab treatment	15
Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study	14
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82	14
The repertoire of germline variants in patients with early‐onset rectal cancer	14
Retreatment in locally recurrent nasopharyngeal carcinoma: Current status and perspectives	14
Partial hepatectomy versus interventional treatment in patients with hepatitis B virus‐related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinica	13
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Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy	13
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Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors	13
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Cover Image, Volume 44, Issue 6	12
Candidate therapeutic agents in a newly established triple wild‐type mucosal melanoma cell line	12
Nasopharyngeal carcinoma treatment paradigm after HK0501 – a potential way forward	12
Efficacy and safety of KN026 and docetaxel for HER2‐positive breast cancer: a phase II clinical trial	12
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Issue Information	12
p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases	12
Issue Information	12
Establishment of an orthotopic perirenal space xenograft mouse model of retroperitoneal sarcoma	12
MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria‐dependent dephosphorylation of EGFR	11
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Neoadjuvant chemotherapy plus anlotinib in the treatment of resectable head and neck squamous cell carcinoma: A pilot phase II trial	11
MAGE‐C3 promotes cancer metastasis by inducing epithelial‐mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma	11
Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial	11
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer	11
RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment	11
Parkin deficiency promotes colorectal tumorigenesis and progression through RIPK3‐dependent necroptotic inflammation	11
The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy	10
Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer	10
Evolution of tumor microenvironment in colorectal liver metastases under treatment stress	10
Outcomes and toxicities of immune checkpoint inhibitors in colorectal cancer: a real‐world retrospective analysis	10
Proteomic identification of new diagnostic biomarkers of early‐stage cutaneous mycosis fungoides	10
Real‐world data on ALK rearrangement test in Chinese advanced non‐small cell lung cancer (RATICAL): a nationwide multicenter retrospective study	10
P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer	10
Correction to: Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating c‐x‐c motif chemokine receptor 4	9
Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates	9
HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program	9
Safety and immunogenicity of a third dose of mRNA‐1273 vaccine among cancer patients	9

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a “hit‐and‐run” paradigm	9
Oral transforming growth factor‐beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti‐tumor immunity	9
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis	9
The Fibrillin‐1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells	9
Validation of different personalized risk models of chemotherapy‐induced nausea and vomiting: results of a randomized, double‐blind, phase III trial of fosaprepitant for cancer patients treated with h	9
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells	9
Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis	8
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Concurrent chemoradiotherapyof different radiation doses and different irradiation fields for locally advanced thoracic esophageal squamous cell carcinoma: A randomized, multicenter, phase III clinica	8
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Phosphatidylserine released from apoptotic cells in tumor induces M2‐like macrophage polarization through the PSR‐STAT3‐JMJD3 axis	8
Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β₂‐AR/MACC1 axis	8
The long‐term spatiotemporal trends in lung cancer burden and its risk factors at global, regional, and national levels, 1992‐2021: The Global Burden of Disease Study 2021	8
Epi‐immunotherapy for cancers: rationales of epi‐drugs in combination with immunotherapy and advances in clinical trials	8
The SARS‐CoV‐2 spike protein induces lung cancer migration and invasion in a TLR2‐dependent manner	7
Detection of piRNA‐54265 in human serum: evidence and significance	7
A phase Ib/II study of fruquintinib in combination with paclitaxel as the second‐line therapy for advanced gastric cancer	7
Single‐cell atlas reveals a distinct immune profile fostered by T cell‐B cell crosstalk in triple negative breast cancer	7
N6‐methyladenosine‐modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis‐regulated Hippo pathway	7
Dietary long‐chain fatty acid metabolism boosts antitumor immune response	7
Ferroptosis in cancer and cancer immunotherapy	7
Tumor‐derived insulin‐like growth factor‐binding protein‐1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors	7
Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized controlled trial	7
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy	7
Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec‐15 axis in immune escape	7
Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation	7
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities	7
Infection complications in febrile chimeric antigen receptor (CAR)‐T recipients during the peri‐CAR‐T cell treatment period examined using metagenomic next‐generation sequencing (mNGS)	6
Serologic status and safety of inactivated Covid‐19 vaccine for hepatocellular carcinoma patients with cirrhosis after curative liver resection	6
Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis	6
Issue Information	6
Antitumoral effects of cannabis in Notch1‐mutated T‐cell acute lymphoblastic leukemia	6
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m⁶A RNA methylation in ocular melanoma	6
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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma	6
Issue Information	6
Evaluation of renal cancer progression in a mouse model of heart failure	6
Immunologic tumor microenvironment modulators for turning cold tumors hot	6
Issue Information	6
Issue Information	6
Limitation and challenges in using pancreatic cancer‐derived organoids as a preclinical tool	6
Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter	5
PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer	5
Clinical outcomes of second‐line treatment following first‐line VEGFR‐TKI failure in patients with metastatic renal cell carcinoma: a comparison of axitinib alone and axitinib plus anti‐PD‐1 antibody	5
Issue Information	5
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Cover Image, Volume 42, Issue 1	5
Cover Image, Volume 42, Issue 1	5
Association between antipsychotic agents and risk of lung cancer: a nested case‐control study	5
FOXO1 or not FOXO1: that is the question	5
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Targeted STAT1 therapy for LZTR1‐driven peripheral nerve sheath tumor	5
Issue Information	5
Featured Cover	5
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CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway	5
Discovery of a novel viroid‐like circular RNA in colorectal cancer	5
Single whole‐genome sequencing analysis of metastatic biopsy is sufficient for investigational treatment opportunities in cancer	5
Targeting IL‐17A to manage immunotherapy‐induced toxicity in melanoma	5
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Combination of anti‐PD‐L1 antibody with peptide MEL‐dKLA targeting M2 tumor‐associated macrophages suppresses breast cancer metastasis	4
Efficacy, safety and biomarkers of SG001 for patients with previously treated recurrent or metastatic cervical cancer: an open‐label, multicenter, phase Ib trial	4
N6‐methyladenosine modification of CENPF mRNA facilitates gastric cancer metastasis via regulating FAK nuclear export	4
Unraveling the routes to distant metastases in colorectal cancer: Tumor deposits and lymph node metastases as the gateway	4
Impact of small molecule‐mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism	4
Cover Image, Volume 44, Issue 3	4
Issue Information	4
Issue Information	4
Mitochondria‐targeted atovaquone promotes anti‐lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti‐tumor immune cells	4
Cover Image, Volume 43, Issue 5	4
Association of previously irradiated stable brain metastases with outcomes of atezolizumab‐treated non‐small cell lung cancer: A pooled analysis of individual patient data from three randomized trials	4
Prognostic value of single‐nucleotide polymorphisms for extranodal natural killer/T‐cell lymphoma: the identification of risk factors in the molecular era	4
Transient and DNA‐free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis	4
Intercellular communications and metabolic reprogramming as new predictive markers for immunotherapy responses in gastric cancer	4
Single‐cell transcriptomic analysis uncovers intratumoral heterogeneity and drug‐tolerant persister in ALK‐rearranged lung adenocarcinoma	4
Neoadjuvant immune checkpoint inhibitor plus chemotherapy in rare tracheal tumors	4
Abrogation of nuclear entry of TERT by fructose 1,6‐bisphosphatase 1‐mediated dephosphorylation	4
Cancer diagnosis is one quarter lower than the expected cancer incidence in the first year of COVID‐19 pandemic in Germany: A retrospective register‐based cohort study	4
A multimodal integrative approach to model transcriptional addiction of thyroid cancer on RUNX2	4
Genetic alternations and immune characteristics in patients with small cell lung cancer	4
Licochalcone A suppresses Sp1 expression with potential anti‐myeloma activity	4
Programmed death ligand‐1 regulates angiogenesis and metastasis by participating in the c‐JUN/VEGFR2 signaling axis in ovarian cancer	3
Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target	3
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress‐driven hepatocellular carcinoma progression	3
Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer	3
Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene	3
Conserved immuno‐collagenic subtypes predict response to immune checkpoint blockade	3
Protein tyrosine phosphatases: emerging role in cancer therapy resistance	3
The establishment of polypeptide PSMA‐targeted chimeric antigen receptor‐engineered natural killer cells for castration‐resistant prostate cancer and the induction of ferroptosis‐related cell death	3
SERPINE2 promotes liver cancer metastasis by inhibiting c‐Cbl‐mediated EGFR ubiquitination and degradation	3
Incidence of and survival with bone and soft tissue sarcoma: A nation‐wide study over four decades	3
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma	3
JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte‐derived leptin	3
The theory of tumor ecosystem	3