Nature Metabolism

Article	Citations
The cell cycle loops UTP around CAD	1237
Incretin-based therapeutics for the treatment of neurodegenerative diseases	545
Phagocytosis in the retina promotes local insulin production in the eye	490
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	479
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	476
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	281
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	247
NAD kinase essentiality in cancer: in real life, it is all about folates	209
PFKM governs metabolic shifts throughout skeletal muscle differentiation	209
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	196
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	188
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	186
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	184
The cyclic metabolic switching theory of intermittent fasting	183
The rs1421085 variant within FTO promotes brown fat thermogenesis	177
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	174
Epigenetic adaptation of beta cells across lifespan and disease	172
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	170
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	164
DGAT1 mediates sex-specific CD8+ T cell antitumour responses	162
Glycolysis modulates efferocytosis in a noncanonical manner	159
Heterogeneous sympathetic control of brown adipose tissue	153
Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum	151
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	150
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	146

A BCAA–haem axis regulates brown fat function	146
Methylation, acetylation and cell fate	141
Fuelling the fire: de novo lipogenesis primes thermogenesis	141
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	141
Shaping the future of cardiometabolic innovation: advances and opportunities	137
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	137
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	134
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	133
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	130
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	128
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	126
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	121
Hypermetabolism and energetic constraints in mitochondrial disorders	117
The thyroid gland under Notch control	116
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	115
Gut bacteria thwart the blood sugar-lowering effect of acarbose	115
TKT deficiency puts Tregs to rest	114
Best practices in collecting and reporting continuous glucose monitoring data in research settings	114
The antitumour effects of caloric restriction are mediated by the gut microbiome	113
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	113
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	108
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	108
Spatial metabolomics: from a niche field towards a driver of innovation	107
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	106
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	106
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	104
Why a good lab website matters	101
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	100
Fat sensory cues in early life program central response to food and obesity	99
Hypometabolism with the speed of ultrasound	98
A RalA between high-fat diet and mitochondrial shape	98
Sweet signals for myelin: glucose sensing redirected to regeneration	97
A systematic mutational framework for studying oxidative phosphorylation-related proteins	97
Querying stool for dietary information	97
Gases define redox signalling: NO, H2S, O2 … and cyanide	97
Beyond Warburg: LDHA activates RAC for tumour growth	96
Proline fuels ILC3s to maintain gut health	95
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance	94
Fuelling synapses via lipid metabolism	94
Illuminating the ‘healthy obese’ phenotype	93
Mitochondrial RNA stimulates beige adipocyte development in young mice	92
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	92
Methionine and H2S alter cancer–immune dialogue	92
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	92
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	87
A century of the Warburg effect	87
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	87
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	86
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	85
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	84

A researcher’s guide to preclinical mouse NASH models	83
Neurometabolism in focus	82
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	82
An integrated single-cell islet atlas in health and disease	81
Cancer metabolite blunts immunity	80
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	79
Lighting up targets of dual agonist therapies for diabetes and obesity	79
Asters: rising stars in the cholesterol universe	79
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	78
Feeding the hippocampus … with specific nutrients	78
Itaconate boosts type I IFN response by disrupting cytoprotection	78
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	77
Insulin induces insulin receptor degradation in the liver through EphB4	77
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	77
Mapping the plasma metabolome to human health and disease in 274,241 adults	77
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	76
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	75
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	74
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	74
GLP-2 attenuates antipsychotics’ adverse metabolic effects	74
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	73
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming	72
Human basal metabolic rate has declined over the past 30 years	72
Overcoming dietary dogmas	71
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function	71
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease	70
Angiocrine breakdown in metabolically stressed fat	70
Spatial protein gradients pattern liver metabolism	70
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	70
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	69
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	69
The genetics of obesity: aetiology, prevention and therapy	68
Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells	68
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	67
Principles and functions of metabolic compartmentalization	67
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	67
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	67
TM6SF2 as new intestinal lipid player	66
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	66
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	65
MCT1 helps brown fat suck up succinate	64
A common framework for mouse hypothalamic cell atlases	64
Proteogenomic mapping sets stage for precision medicine	63
Career pathways, part 12	63
Do not overlook the role of fructose in obesity	62
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	62
A catecholamine-independent pathway controlling adaptive adipocyte lipolysis	62
Bile acid binds heart failure and inflammation	62
Iron at the intersection of macrophage–adipocyte interactions	61
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	60
NAD+ precursor supplementation in human ageing: clinical evidence and challenges	60
A food-sensitive olfactory circuit drives anticipatory satiety	59
Mitochondrial iNOS blocks itaconate production by interacting with IRG1	59
Systemic proteome adaptions to 7-day complete caloric restriction in humans	59
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	58
Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells	57
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	57
Drowning in cysteine	57
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	56
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	56
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	56
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	56
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	55
Career pathways, part 9	55
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	55
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	54
Mitochondrial function and phenotype are defined by bioenergetics	54
Revisiting the role of serine metabolism in hepatic lipogenesis	54
Anaplerosis in action	53
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	53
Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery	52
Differential mechanisms affecting weight loss and weight loss maintenance	52
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	52
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	52
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	52
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	52
NAD+ regeneration drives cancer cell proliferation	52
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	51
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	50
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	50

Longitudinal multimorbidity trajectories shape personalized glycaemic patterns	50
Liraglutide restores impaired associative learning in individuals with obesity	50
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	50
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	49
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	49
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	49
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	49
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	49
Metabolic Messengers: itaconate	48
Adipose glutaminolysis resurfaces in metabolic disease	48
Signalling from adipose tissue to the brain is not just about leptin	47
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	47
A derivative of the ancient drug salicylate for obesity treatment	47
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	47
A multi-omic trip through the human gut	47
Overlooked confounding in studies of metabolite salts	47
Vestibular nucleus mediation of motion sickness has implications for obesity control	47
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	46
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	46
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	46
Activation of GPR81 by lactate drives tumour-induced cachexia	46
GAPDH redox redux—rewiring pentose phosphate flux	46
Mitochondrial NAD+ drives liver regeneration	45
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	45
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	45
Career pathways, part 19	44
Phenotypic profiling of solute carriers characterizes serine transport in cancer	44
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	44
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	44
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	43
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	43
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	43
Obesity-induced inflammation: connecting the periphery to the brain	42
The insulin signalling network	42
A local source of insulin protects the retina against starvation	42
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	42
Raising the bar for sex and gender reporting in research	42
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	42
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	42
SERPINA3C as a mediator of metabolic health in offspring	42
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	41
Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age	41
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans	41
Reawakening cAMP signalling in cancer cachexia	41
H2S as a metabolic saboteur	41
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	40
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	40
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	40
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	40
Cancer tissue of origin constrains the growth and metabolism of metastases	40
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	40
A sex-specific brake on liver oestrogen signalling	39
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome	39
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	39
Metabolic Messengers: endocannabinoids	38
Subcellular quantitative imaging of metabolites at the organelle level	38
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	38
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	37
Innate metabolic responses against viral infections	37
A brief guide to statistical analysis of grouped data in preclinical research	37
Weighing in on the incretin revolution	37
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture	37
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	37
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD	37
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	37
Serine synthesis promotes bone degradation	36
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	36
Itaconate trims the fat	36
Considerations for designing and analysing inter-generational studies in rodents	36
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	36
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	36
Mitochondrial DNA editing with mitoARCUS	36
Artificial intelligence in metabolic research	35
Epitranscriptomics in metabolic disease	35
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	35
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	35
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	35
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	35
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	35
Metabolic engineering for optimized CAR-T cell therapy	35
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	35
The story of amylin: from physiology to therapy	35
Triglycerides are an important fuel reserve for synapse function in the brain	35
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	35