Nature Metabolism

Article	Citations
Incretin-based therapeutics for the treatment of neurodegenerative diseases	950
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	542
Glycolysis modulates efferocytosis in a noncanonical manner	470
The cell cycle loops UTP around CAD	385
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	358
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	347
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	315
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	302
NAD kinase essentiality in cancer: in real life, it is all about folates	286
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	225
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	225
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	205
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	188
Phagocytosis in the retina promotes local insulin production in the eye	187
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	173
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	152
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	146
The rs1421085 variant within FTO promotes brown fat thermogenesis	145
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	141
The cyclic metabolic switching theory of intermittent fasting	141
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	141
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	140
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	137
Hot news about temperature and lifespan	137
A BCAA–haem axis regulates brown fat function	136

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	132
Fuelling the fire: de novo lipogenesis primes thermogenesis	127
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	125
Hypermetabolism and energetic constraints in mitochondrial disorders	123
Best practices in collecting and reporting continuous glucose monitoring data in research settings	119
Gut bacteria thwart the blood sugar-lowering effect of acarbose	118
The thyroid gland under Notch control	118
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	117
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	115
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	113
The antitumour effects of caloric restriction are mediated by the gut microbiome	111
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	110
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	110
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	109
Shaping the future of cardiometabolic innovation: advances and opportunities	107
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	107
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	104
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	104
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	103
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	102
TKT deficiency puts Tregs to rest	100
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	100
Spatial metabolomics: from a niche field towards a driver of innovation	100
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	98
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	97
Illuminating the ‘healthy obese’ phenotype	94
Fuelling synapses via lipid metabolism	92
Gases define redox signalling: NO, H2S, O2 … and cyanide	88
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	87
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	87
Querying stool for dietary information	86
Beyond Warburg: LDHA activates RAC for tumour growth	86
Why a good lab website matters	85
Mitochondrial RNA stimulates beige adipocyte development in young mice	84
A RalA between high-fat diet and mitochondrial shape	81
Methionine and H2S alter cancer–immune dialogue	81
Hypometabolism with the speed of ultrasound	81
A systematic mutational framework for studying oxidative phosphorylation-related proteins	81
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	80
Proline fuels ILC3s to maintain gut health	80
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	79
A researcher’s guide to preclinical mouse NASH models	79
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis	78
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	77
A century of the Warburg effect	77
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	77
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	77
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	76
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	76
Neurometabolism in focus	76

An integrated single-cell islet atlas in health and disease	75
Human basal metabolic rate has declined over the past 30 years	73
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	73
Cancer metabolite blunts immunity	73
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	72
Lighting up targets of dual agonist therapies for diabetes and obesity	72
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	71
Asters: rising stars in the cholesterol universe	71
GLP-2 attenuates antipsychotics’ adverse metabolic effects	70
Central regulation of the anorexigenic receptor GFRAL	70
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	70
Feeding the hippocampus … with specific nutrients	70
Itaconate boosts type I IFN response by disrupting cytoprotection	67
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	66
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	66
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	65
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	65
Mapping the plasma metabolome to human health and disease in 274,241 adults	65
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	65
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	64
Principles and functions of metabolic compartmentalization	64
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	64
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	64
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	64
Insulin induces insulin receptor degradation in the liver through EphB4	64
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	62
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	62
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	62
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function	62
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	61
TM6SF2 as new intestinal lipid player	60
MCT1 helps brown fat suck up succinate	60
Do not overlook the role of fructose in obesity	60
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	60
Iron at the intersection of macrophage–adipocyte interactions	59
A common framework for mouse hypothalamic cell atlases	58
Bile acid binds heart failure and inflammation	58
Proteogenomic mapping sets stage for precision medicine	57
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	57
Career pathways, part 12	57
Nuclear PHGDH protects cancer cells from nutrient stress	56
Systemic proteome adaptions to 7-day complete caloric restriction in humans	56
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	56
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	55
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	55
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	53
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	53
A food-sensitive olfactory circuit drives anticipatory satiety	53
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	53
Career pathways, part 9	52
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	52
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	52
Anaplerosis in action	52
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	52
NAD+ regeneration drives cancer cell proliferation	51
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	50
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	50
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	49
Mitochondrial function and phenotype are defined by bioenergetics	49
Differential mechanisms affecting weight loss and weight loss maintenance	49
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	48
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	48
Revisiting the role of serine metabolism in hepatic lipogenesis	48
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	48
Metabolic Messengers: itaconate	48
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	47
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	47
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	46
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	46
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	46
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	46
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	46
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	46
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	45
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	44
Liraglutide restores impaired associative learning in individuals with obesity	44
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	44
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	44
Publisher Correction: A new foe in folate metabolism	43
Adipose glutaminolysis resurfaces in metabolic disease	43

A multi-omic trip through the human gut	43
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	43
Pentose phosphate pathway drives vascular maturation	43
Science in times of conflict	43
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	42
GAPDH redox redux—rewiring pentose phosphate flux	42
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	42
The insulin signalling network	41
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	41
Vestibular nucleus mediation of motion sickness has implications for obesity control	41
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	41
Signalling from adipose tissue to the brain is not just about leptin	41
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	41
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	41
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	40
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	40
Overlooked confounding in studies of metabolite salts	40
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	40
A derivative of the ancient drug salicylate for obesity treatment	40
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	39
Phenotypic profiling of solute carriers characterizes serine transport in cancer	39
Activation of GPR81 by lactate drives tumour-induced cachexia	39
A local source of insulin protects the retina against starvation	39
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	39
Obesity-induced inflammation: connecting the periphery to the brain	39
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	39
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	39
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	39
SERPINA3C as a mediator of metabolic health in offspring	38
A blood-to-brain delivery system to treat obesity	38
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	38
Raising the bar for sex and gender reporting in research	38
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	38
Mitochondrial DNA editing with mitoARCUS	38
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	37
Innate metabolic responses against viral infections	37
What about sex?	36
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD	36
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	36
Considerations for designing and analysing inter-generational studies in rodents	36
Subcellular quantitative imaging of metabolites at the organelle level	36
A brief guide to statistical analysis of grouped data in preclinical research	36
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	36
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	35
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	35
Metabolic Messengers: endocannabinoids	35
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	35
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	35
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	35
H2S as a metabolic saboteur	34
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	34
Cancer tissue of origin constrains the growth and metabolism of metastases	34
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	34
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	34
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	34
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	33
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass	33
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	33
Serine synthesis promotes bone degradation	33
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	33
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	33
Itaconate trims the fat	33
Triglycerides are an important fuel reserve for synapse function in the brain	33
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	32
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	32
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	32
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	32
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	32
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	31
Metabolic engineering for optimized CAR-T cell therapy	31
Epitranscriptomics in metabolic disease	31
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	31
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	30
Mitochondrial superoxide regulates pro-inflammatory macrophages	30
Interleukin-17 as a key player in neuroimmunometabolism	30
Publisher Correction: A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis	30
Five years on	30
Actionable targets to reduce COVID-19 severity	30
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance	30
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	30
Considering co-submissions	30
Gut–liver highway of ALDH2 in drinking	30
Author Correction: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	30