Nature Metabolism

(The TQCC of Nature Metabolism is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Skeletal muscle energy metabolism during exercise469
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo395
Lactate: the ugly duckling of energy metabolism390
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas375
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals341
Gut microbiome pattern reflects healthy ageing and predicts survival in humans289
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism266
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection253
Lipolysis: cellular mechanisms for lipid mobilization from fat stores232
The metabolic roots of senescence: mechanisms and opportunities for intervention229
A metabolic handbook for the COVID-19 pandemic217
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages200
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry197
Fructose stimulated de novo lipogenesis is promoted by inflammation181
Metabolic and epigenetic regulation of T-cell exhaustion179
Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages167
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels163
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity161
Metabolic Messengers: tumour necrosis factor160
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction156
Exercise hormone irisin is a critical regulator of cognitive function143
Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report139
Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis137
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19135
Dihydroxyacetone phosphate signals glucose availability to mTORC1132
Metabolic Messengers: FGF21131
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade119
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours108
Central and peripheral GLP-1 systems independently suppress eating106
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice105
The gut microbial metabolite formate exacerbates colorectal cancer progression104
Interleukin 6 as an energy allocator in muscle tissue103
A molecular mechanism explaining albuminuria in kidney disease102
Selenium detoxification is required for cancer-cell survival101
Metabolic communication during exercise100
Molecular consequences of SARS-CoV-2 liver tropism98
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction96
GTTs and ITTs in mice: simple tests, complex answers93
The ins and outs of serine and glycine metabolism in cancer90
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma89
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms88
Mitochondrial pyruvate carriers are required for myocardial stress adaptation88
Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality88
Can COVID-19 cause diabetes?88
An artificial intelligence decision support system for the management of type 1 diabetes87
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy86
Space-time logic of liver gene expression at sub-lobular scale86
POMC neuronal heterogeneity in energy balance and beyond: an integrated view85
The small intestine shields the liver from fructose-induced steatosis84
UCP1 governs liver extracellular succinate and inflammatory pathogenesis83
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer81
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice80
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism80
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes78
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication78
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms77
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis76
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice76
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study75
Metabolic Messengers: glucagon-like peptide 175
Metabolic Messengers: bile acids73
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress72
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy71
Central anorexigenic actions of bile acids are mediated by TGR570
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding70
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities70
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism70
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function68
Central nervous system regulation of organismal energy and glucose homeostasis68
Analyzing cell-type-specific dynamics of metabolism in kidney repair67
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes67
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus67
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age66
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling66
Defining the lineage of thermogenic perivascular adipose tissue66
Nuclear metabolism and the regulation of the epigenome66
Human thermogenic adipocyte regulation by the long noncoding RNA LINC0047365
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution64
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes64
Metabolic regulation of skeletal cell fate and function in physiology and disease64
KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth64
Revisiting energy expenditure: how to correct mouse metabolic rate for body mass64
A genetic map of the mouse dorsal vagal complex and its role in obesity63
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity63
Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication62
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils62
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells61
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans61
Exercise and cardiac health: physiological and molecular insights61
Effects of maternal and paternal exercise on offspring metabolism61
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution60
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes58
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth57
Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue57
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol57
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes56
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA56
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation56
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity55
Profound and redundant functions of arcuate neurons in obesity development54
DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes53
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity53
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes52
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice51
Metabolic remodelling during early mouse embryo development51
Mitochondrial heterogeneity and homeostasis through the lens of a neuron51
Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle50
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix50
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism50
A researcher’s guide to preclinical mouse NASH models49
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation49
Postprandial glycaemic dips predict appetite and energy intake in healthy individuals49
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-307548
N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation48
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance47
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice47
Exercise-induced 3′-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring46
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions46
CAR-based therapies: opportunities for immuno-medicine beyond cancer46
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model46
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers46
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation45
Reciprocal regulation of cellular mechanics and metabolism44
Systemic induction of senescence in young mice after single heterochronic blood exchange44
Mice as experimental models for human physiology: when several degrees in housing temperature matter44
A large-scale genome–lipid association map guides lipid identification44
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health44
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination43
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases43
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes42
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites42
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth42
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation42
Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming41
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism41
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration40
Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas40
Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation40
Secretin activates brown fat and induces satiation40
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages40
Serine catabolism generates liver NADPH and supports hepatic lipogenesis40
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity40
Introducing the Lipidomics Minimal Reporting Checklist39
TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis38
Identification of a regulatory pathway inhibiting adipogenesis via RSPO238
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation38
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease38
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma38
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells37
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia37
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan37
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex37
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages37
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen36
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM1636
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance36
Tetracyclines promote survival and fitness in mitochondrial disease models36
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism36
Human plasma proteomic profiles indicative of cardiorespiratory fitness36
TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response36
A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements36
The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress35
Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly35
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding35
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation35
Quantitative flux analysis in mammals35
Altered propionate metabolism contributes to tumour progression and aggressiveness35
Mind your media35
Genetics of extreme human longevity to guide drug discovery for healthy ageing34
An orthogonal metabolic framework for one-carbon utilization34
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth34
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv234
The pentose phosphate pathway in health and disease34
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages34
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin34
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice34
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity34
Consequences of the COVID-19 pandemic for patients with metabolic diseases33
Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise33
Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness33
Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism33
Angiocrine polyamine production regulates adiposity33
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development33
Methionine synthase is essential for cancer cell proliferation in physiological folate environments32
Principles and functions of metabolic compartmentalization32
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity32
Human metabolome variation along the upper intestinal tract32
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation32
Polyamine pathway activity promotes cysteine essentiality in cancer cells32
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation32
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease32
Innate metabolic responses against viral infections32
Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics31
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation30
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity30
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited30
Hindbrain circuits in the control of eating behaviour and energy balance30
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation30
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis30
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK30
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness29
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment29
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization29
AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury29
Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals29
Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats29
Age-related loss of gene-to-gene transcriptional coordination among single cells29
white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila29
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome29
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma29