Nature Metabolism

Article	Citations
Skeletal muscle energy metabolism during exercise	448
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo	374
Lactate: the ugly duckling of energy metabolism	374
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas	367
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals	323
Gut microbiome pattern reflects healthy ageing and predicts survival in humans	274
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism	250
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection	248
A metabolic handbook for the COVID-19 pandemic	216
The metabolic roots of senescence: mechanisms and opportunities for intervention	214
Lipolysis: cellular mechanisms for lipid mobilization from fat stores	213
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages	198
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry	196
Fructose stimulated de novo lipogenesis is promoted by inflammation	179
Metabolic and epigenetic regulation of T-cell exhaustion	173
Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages	164
Metabolic Messengers: tumour necrosis factor	157
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels	157
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction	154
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	147
Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report	139
Exercise hormone irisin is a critical regulator of cognitive function	135
Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis	134
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19	131
Dihydroxyacetone phosphate signals glucose availability to mTORC1	130

Metabolic Messengers: FGF21	125
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade	114
NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism	106
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours	105
Central and peripheral GLP-1 systems independently suppress eating	103
The gut microbial metabolite formate exacerbates colorectal cancer progression	101
A molecular mechanism explaining albuminuria in kidney disease	100
Selenium detoxification is required for cancer-cell survival	98
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	98
Molecular consequences of SARS-CoV-2 liver tropism	97
Metabolic communication during exercise	97
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1	97
Interleukin 6 as an energy allocator in muscle tissue	91
An artificial intelligence decision support system for the management of type 1 diabetes	88
GTTs and ITTs in mice: simple tests, complex answers	88
Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality	87
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms	87
Can COVID-19 cause diabetes?	87
Mitochondrial pyruvate carriers are required for myocardial stress adaptation	86
Identifying strategies to target the metabolic flexibility of tumours	86
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction	84
The ins and outs of serine and glycine metabolism in cancer	84
Space-time logic of liver gene expression at sub-lobular scale	83
The small intestine shields the liver from fructose-induced steatosis	82
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy	82
UCP1 governs liver extracellular succinate and inflammatory pathogenesis	81
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma	81
POMC neuronal heterogeneity in energy balance and beyond: an integrated view	80
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer	79
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice	79
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes	77
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms	76
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	75
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study	75
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism	75
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice	74
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis	73
Metabolic Messengers: glucagon-like peptide 1	73
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress	71
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism	70
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities	69
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding	67
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy	67
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function	67
Central nervous system regulation of organismal energy and glucose homeostasis	66
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling	66
Nuclear metabolism and the regulation of the epigenome	66
Central anorexigenic actions of bile acids are mediated by TGR5	65
Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473	64
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age	64

Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes	64
Single-cell omics in ageing: a young and growing field	64
Metabolic Messengers: bile acids	63
A genetic map of the mouse dorsal vagal complex and its role in obesity	63
Analyzing cell-type-specific dynamics of metabolism in kidney repair	63
Defining the lineage of thermogenic perivascular adipose tissue	62
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes	62
KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth	62
Revisiting energy expenditure: how to correct mouse metabolic rate for body mass	62
Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication	61
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution	60
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils	60
Exercise and cardiac health: physiological and molecular insights	60
Effects of maternal and paternal exercise on offspring metabolism	60
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity	60
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans	59
Metabolic regulation of skeletal cell fate and function in physiology and disease	59
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution	58
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	58
Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure	58
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells	58
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA	56
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth	56
NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase	55
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity	54
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes	54
Profound and redundant functions of arcuate neurons in obesity development	53
DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes	53
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes	53
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	53
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity	52
Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue	51
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	49
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation	49
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice	49
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes	48
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	48
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism	48
Metabolic remodelling during early mouse embryo development	47
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance	47
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers	46
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice	46
Mitochondrial heterogeneity and homeostasis through the lens of a neuron	46
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions	46
Postprandial glycaemic dips predict appetite and energy intake in healthy individuals	45
Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle	45
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	45
Exercise-induced 3′-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring	45
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model	45
N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation	44
CAR-based therapies: opportunities for immuno-medicine beyond cancer	44
Mice as experimental models for human physiology: when several degrees in housing temperature matter	43
Reciprocal regulation of cellular mechanics and metabolism	43
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health	43
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075	43
A large-scale genome–lipid association map guides lipid identification	43
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes	42
A researcher’s guide to preclinical mouse NASH models	42
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination	42
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases	41
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites	41
Secretin activates brown fat and induces satiation	40
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth	40
Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming	40
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity	39
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation	39
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	39
Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation	39
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	38
Systemic induction of senescence in young mice after single heterochronic blood exchange	38
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	38
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease	38
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells	37
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	37
TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response	36
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	36
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan	36
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia	36
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex	35
The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress	35

Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism	35
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	35
Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas	35
Quantitative flux analysis in mammals	35
Introducing the Lipidomics Minimal Reporting Checklist	35
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages	35
Tetracyclines promote survival and fitness in mitochondrial disease models	35
Mind your media	34
Altered propionate metabolism contributes to tumour progression and aggressiveness	34
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice	34
Human plasma proteomic profiles indicative of cardiorespiratory fitness	34
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation	34
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity	34
Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly	34
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin	34
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	34
Consequences of the COVID-19 pandemic for patients with metabolic diseases	33
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	33
A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements	33
Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise	33
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	33
Polyamine pathway activity promotes cysteine essentiality in cancer cells	32
TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis	32
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages	32
Genetics of extreme human longevity to guide drug discovery for healthy ageing	32
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease	32
Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism	32
An orthogonal metabolic framework for one-carbon utilization	32
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	32
Angiocrine polyamine production regulates adiposity	31
Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness	31
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development	31
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation	31
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	31
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding	31
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16	31
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation	31
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis	30
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK	30
Principles and functions of metabolic compartmentalization	30
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity	30
The pentose phosphate pathway in health and disease	30
Age-related loss of gene-to-gene transcriptional coordination among single cells	29
white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila	29
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited	29
AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury	29
Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics	29
Innate metabolic responses against viral infections	29
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity	29
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation	29
Human metabolome variation along the upper intestinal tract	29
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization	29
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma	28
The metabolic growth limitations of petite cells lacking the mitochondrial genome	28
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome	28
Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats	28
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation	28
Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals	28
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation	28
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment	28