Nature Metabolism

Article	Citations
Glycolysis modulates efferocytosis in a noncanonical manner	917
The cell cycle loops UTP around CAD	525
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	460
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	367
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	336
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	332
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	304
Phagocytosis in the retina promotes local insulin production in the eye	270
NAD kinase essentiality in cancer: in real life, it is all about folates	270
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	218
Incretin-based therapeutics for the treatment of neurodegenerative diseases	217
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	198
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	177
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	170
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	165
The cyclic metabolic switching theory of intermittent fasting	148
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	143
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	140
The rs1421085 variant within FTO promotes brown fat thermogenesis	137
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	135
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	132
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	130
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	129
Best practices in collecting and reporting continuous glucose monitoring data in research settings	129
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	128

Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	127
Hypermetabolism and energetic constraints in mitochondrial disorders	121
The antitumour effects of caloric restriction are mediated by the gut microbiome	117
Shaping the future of cardiometabolic innovation: advances and opportunities	116
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	115
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	113
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	112
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	110
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	107
TKT deficiency puts Tregs to rest	107
Fuelling the fire: de novo lipogenesis primes thermogenesis	106
The thyroid gland under Notch control	105
Gut bacteria thwart the blood sugar-lowering effect of acarbose	104
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	103
Hot news about temperature and lifespan	103
A BCAA–haem axis regulates brown fat function	101
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	101
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	100
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	100
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	98
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	98
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	98
Spatial metabolomics: from a niche field towards a driver of innovation	97
Querying stool for dietary information	96
Why a good lab website matters	95
A systematic mutational framework for studying oxidative phosphorylation-related proteins	94
Hypometabolism with the speed of ultrasound	93
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	92
A RalA between high-fat diet and mitochondrial shape	92
Proline fuels ILC3s to maintain gut health	92
Beyond Warburg: LDHA activates RAC for tumour growth	90
Methionine and H2S alter cancer–immune dialogue	86
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	85
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	85
A researcher’s guide to preclinical mouse NASH models	83
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	82
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	82
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	81
Mitochondrial RNA stimulates beige adipocyte development in young mice	79
Fuelling synapses via lipid metabolism	78
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	77
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	77
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	77
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis	76
Illuminating the ‘healthy obese’ phenotype	76
Gases define redox signalling: NO, H2S, O2 … and cyanide	76
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	75
Cancer metabolite blunts immunity	74
A century of the Warburg effect	74
Neurometabolism in focus	74

An integrated single-cell islet atlas in health and disease	73
Feeding the hippocampus … with specific nutrients	71
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	71
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	71
Asters: rising stars in the cholesterol universe	71
Human basal metabolic rate has declined over the past 30 years	71
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	70
Itaconate boosts type I IFN response by disrupting cytoprotection	70
Fixing lymphatics improves glucose metabolism	70
GLP-2 attenuates antipsychotics’ adverse metabolic effects	70
Central regulation of the anorexigenic receptor GFRAL	70
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	70
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	68
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	68
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	67
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	67
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	67
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	66
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	66
Lighting up targets of dual agonist therapies for diabetes and obesity	65
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	63
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	63
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	63
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	62
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	62
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	62
Insulin induces insulin receptor degradation in the liver through EphB4	62
Principles and functions of metabolic compartmentalization	61
Do not overlook the role of fructose in obesity	61
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	61
A common framework for mouse hypothalamic cell atlases	60
Career pathways, part 12	60
MCT1 helps brown fat suck up succinate	60
Proteogenomic mapping sets stage for precision medicine	60
TM6SF2 as new intestinal lipid player	60
Bile acid binds heart failure and inflammation	59
A food-sensitive olfactory circuit drives anticipatory satiety	58
Iron at the intersection of macrophage–adipocyte interactions	58
Nuclear PHGDH protects cancer cells from nutrient stress	57
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	57
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	56
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	56
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	56
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	56
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	56
Systemic proteome adaptions to 7-day complete caloric restriction in humans	55
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	54
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	54
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	54
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	54
NAD+ regeneration drives cancer cell proliferation	53
Anaplerosis in action	53
Career pathways, part 9	53
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	52
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	51
Liraglutide restores impaired associative learning in individuals with obesity	50
Differential mechanisms affecting weight loss and weight loss maintenance	50
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	49
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	49
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	49
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	48
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	48
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	48
Revisiting the role of serine metabolism in hepatic lipogenesis	48
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	47
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	46
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	46
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	46
Mitochondrial function and phenotype are defined by bioenergetics	46
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	45
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	45
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	45
Metabolic Messengers: itaconate	44
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	44
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	44
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	43
Umami taste—a novel mechanism driving food intake and obesity	43
Adipose glutaminolysis resurfaces in metabolic disease	43
A multi-omic trip through the human gut	43
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	43

Publisher Correction: A new foe in folate metabolism	43
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	42
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	42
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	42
Pentose phosphate pathway drives vascular maturation	42
Science in times of conflict	42
Overlooked confounding in studies of metabolite salts	41
Signalling from adipose tissue to the brain is not just about leptin	41
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	41
GAPDH redox redux—rewiring pentose phosphate flux	41
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	41
Vestibular nucleus mediation of motion sickness has implications for obesity control	41
The insulin signalling network	40
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	40
A derivative of the ancient drug salicylate for obesity treatment	40
Obesity-induced inflammation: connecting the periphery to the brain	40
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	39
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	39
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	39
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	39
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	39
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	39
Phenotypic profiling of solute carriers characterizes serine transport in cancer	39
A blood-to-brain delivery system to treat obesity	38
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	38
SERPINA3C as a mediator of metabolic health in offspring	38
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	38
Raising the bar for sex and gender reporting in research	38
Activation of GPR81 by lactate drives tumour-induced cachexia	38
A local source of insulin protects the retina against starvation	38
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	37
Subcellular quantitative imaging of metabolites at the organelle level	37
What about sex?	37
Mitochondrial DNA editing with mitoARCUS	37
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	37
Innate metabolic responses against viral infections	36
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	36
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	36
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	36
Metabolic Messengers: endocannabinoids	35
A brief guide to statistical analysis of grouped data in preclinical research	35
Considerations for designing and analysing inter-generational studies in rodents	35
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	35
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	35
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	35
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	34
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	34
Cancer tissue of origin constrains the growth and metabolism of metastases	34
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	34
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family	34
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	34
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	34
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	33
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	33
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	33
Serine synthesis promotes bone degradation	33
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	33
Itaconate trims the fat	33
H2S as a metabolic saboteur	33
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	32
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	32
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	32
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	32
Triglycerides are an important fuel reserve for synapse function in the brain	32
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	32
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	32
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	32
Metabolic engineering for optimized CAR-T cell therapy	32
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass	32
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	31
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	31
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	31
Five years on	31
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	31
Epitranscriptomics in metabolic disease	31