Nature Metabolism

Article	Citations
NAD kinase essentiality in cancer: in real life, it is all about folates	596
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	581
Glycolysis modulates efferocytosis in a noncanonical manner	579
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice	533
Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum	310
Epigenetic adaptation of beta cells across lifespan and disease	262
Heterogeneous sympathetic control of brown adipose tissue	244
Phagocytosis in the retina promotes local insulin production in the eye	239
The cyclic metabolic switching theory of intermittent fasting	221
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	218
Incretin-based therapeutics for the treatment of neurodegenerative diseases	215
Author Correction: Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy	215
Author Correction: SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth	199
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	194
Exercise and glucagon-like peptide 1 receptor agonists in cardiovascular disease beyond weight loss	192
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	190
PFKM governs metabolic shifts throughout skeletal muscle differentiation	182
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	180
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	177
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	175
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	166
The rs1421085 variant within FTO promotes brown fat thermogenesis	164
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	162
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	156
The cell cycle loops UTP around CAD	156

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	153
DGAT1 mediates sex-specific CD8+ T cell antitumour responses	152
A BCAA–haem axis regulates brown fat function	148
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	147
Methylation, acetylation and cell fate	143
Fuelling the fire: de novo lipogenesis primes thermogenesis	140
The thyroid gland under Notch control	135
Gut bacteria thwart the blood sugar-lowering effect of acarbose	135
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	134
Best practices in collecting and reporting continuous glucose monitoring data in research settings	132
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	129
Shaping the future of cardiometabolic innovation: advances and opportunities	127
Cellular loci for cagrilintide action identified	125
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	124
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	123
Hypermetabolism and energetic constraints in mitochondrial disorders	123
The antitumour effects of caloric restriction are mediated by the gut microbiome	122
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	121
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	119
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	117
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	114
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	112
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	110
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	110
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	107
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	107
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	107
Why a good lab website matters	106
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	106
Mitochondrial RNA stimulates beige adipocyte development in young mice	106
Spatial metabolomics: from a niche field towards a driver of innovation	106
Fuelling synapses via lipid metabolism	104
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	103
Fat sensory cues in early life program central response to food and obesity	103
Hypometabolism with the speed of ultrasound	101
A RalA between high-fat diet and mitochondrial shape	100
A systematic mutational framework for studying oxidative phosphorylation-related proteins	99
Sweet signals for myelin: glucose sensing redirected to regeneration	98
Querying stool for dietary information	96
Methionine and H2S alter cancer–immune dialogue	94
Illuminating the ‘healthy obese’ phenotype	94
Gases define redox signalling: NO, H2S, O2 … and cyanide	92
A century of the Warburg effect	91
Beyond Warburg: LDHA activates RAC for tumour growth	91
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	90
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	87
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	86
A researcher’s guide to preclinical mouse NASH models	86
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	86
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis	86

Proline fuels ILC3s to maintain gut health	85
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance	85
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	85
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	84
An integrated single-cell islet atlas in health and disease	84
Cancer metabolite blunts immunity	83
Lighting up targets of dual agonist therapies for diabetes and obesity	83
Asters: rising stars in the cholesterol universe	82
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	82
Itaconate boosts type I IFN response by disrupting cytoprotection	81
Feeding the hippocampus … with specific nutrients	81
Insulin induces insulin receptor degradation in the liver through EphB4	80
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	80
GLP-2 attenuates antipsychotics’ adverse metabolic effects	79
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	77
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	77
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	76
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	75
Overcoming dietary dogmas	75
Spatial protein gradients pattern liver metabolism	74
Human basal metabolic rate has declined over the past 30 years	74
Angiocrine breakdown in metabolically stressed fat	73
Glycerol is a new ally for heat production and bone health	73
The genetics of obesity: aetiology, prevention and therapy	71
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	71
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming	71
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	70
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	70
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease	70
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	69
Host metabolism can produce many indoles and phenols independently of the microbiome	69
Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells	69
Mapping the plasma metabolome to human health and disease in 274,241 adults	69
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	69
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	68
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function	67
Principles and functions of metabolic compartmentalization	66
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	66
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	66
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	65
TM6SF2 as new intestinal lipid player	64
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	64
MCT1 helps brown fat suck up succinate	63
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	63
A common framework for mouse hypothalamic cell atlases	63
Drowning in cysteine	62
Career pathways, part 12	62
Mitochondrial iNOS blocks itaconate production by interacting with IRG1	62
Do not overlook the role of fructose in obesity	62
Iron at the intersection of macrophage–adipocyte interactions	61
Bile acid binds heart failure and inflammation	61
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	61
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	60
Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut	60
A catecholamine-independent pathway controlling adaptive adipocyte lipolysis	59
A spatial atlas of pancreatic remodelling in type 1 diabetes	59
Systemic proteome adaptions to 7-day complete caloric restriction in humans	58
Proteogenomic mapping sets stage for precision medicine	58
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	57
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	57
A food-sensitive olfactory circuit drives anticipatory satiety	57
Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells	57
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	56
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	56
NAD+ precursor supplementation in human ageing: clinical evidence and challenges	56
Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery	55
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	55
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	55
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	55
Career pathways, part 9	55
Revisiting the role of serine metabolism in hepatic lipogenesis	54
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	54
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	54
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	54
Longitudinal multimorbidity trajectories shape personalized glycaemic patterns	54
Mitochondrial function and phenotype are defined by bioenergetics	54
Differential mechanisms affecting weight loss and weight loss maintenance	53
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	53
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	52
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	52

Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	52
Liraglutide restores impaired associative learning in individuals with obesity	51
Metabolic Messengers: itaconate	51
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	51
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	51
Mitochondrial quality control in human ageing and longevity	50
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	50
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	50
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	50
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	49
Adipose glutaminolysis resurfaces in metabolic disease	49
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	49
Anaplerosis in action	49
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	49
A multi-omic trip through the human gut	48
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	48
Mitochondrial NAD+ drives liver regeneration	47
Phenotypic profiling of solute carriers characterizes serine transport in cancer	47
Signalling from adipose tissue to the brain is not just about leptin	47
A derivative of the ancient drug salicylate for obesity treatment	47
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	47
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	47
Vestibular nucleus mediation of motion sickness has implications for obesity control	47
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	47
Career pathways, part 19	47
Overlooked confounding in studies of metabolite salts	47
GAPDH redox redux—rewiring pentose phosphate flux	46
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	46
Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata	45
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	45
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	45
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	45
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	45
Activation of GPR81 by lactate drives tumour-induced cachexia	44
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	44
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	44
The insulin signalling network	44
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	44
Obesity-induced inflammation: connecting the periphery to the brain	44
SERPINA3C as a mediator of metabolic health in offspring	43
A local source of insulin protects the retina against starvation	43
Reawakening cAMP signalling in cancer cachexia	42
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	42
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome	42
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	42
H2S as a metabolic saboteur	42
Considerations for designing and analysing inter-generational studies in rodents	42
A sex-specific brake on liver oestrogen signalling	42
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	41
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	41
A brief guide to statistical analysis of grouped data in preclinical research	41
Subcellular quantitative imaging of metabolites at the organelle level	41
Weighing in on the incretin revolution	41
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans	41
Mitochondrial DNA editing with mitoARCUS	41
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	41
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD	40
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	40
Cancer tissue of origin constrains the growth and metabolism of metastases	40
Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism	40
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture	40
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	39
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	39
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	39
Innate metabolic responses against viral infections	39
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	39
Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age	39
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	39
Itaconate trims the fat	39
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	38
Often forgotten but essential: long-chain acyl-CoAs in metabolic control	38
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	38
Snake postprandial metabolite shows cross-species activation of hypothalamic neurons	38
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	37
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	37
Serine synthesis promotes bone degradation	37
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	37
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	36
Hypoxia rescues complex 1-associated disease caused by proteostatic defects	36
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	36
Epitranscriptomics in metabolic disease	36
Why machine learning fails at mass spectrometry for small molecules	36
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	36
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	36
Artificial intelligence in metabolic research	36
Metabolic engineering for optimized CAR-T cell therapy	36
Histone butyrylation is a dietary link to epigenetics	35
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	35
Triglycerides are an important fuel reserve for synapse function in the brain	35
Gut–liver highway of ALDH2 in drinking	35
The story of amylin: from physiology to therapy	35
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	35
Five years on	35
Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase	35