Nature Metabolism

Article	Citations
Skeletal muscle energy metabolism during exercise	509
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo	447
Lactate: the ugly duckling of energy metabolism	423
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas	384
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals	367
Gut microbiome pattern reflects healthy ageing and predicts survival in humans	311
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism	289
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection	264
Lipolysis: cellular mechanisms for lipid mobilization from fat stores	251
The metabolic roots of senescence: mechanisms and opportunities for intervention	246
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages	212
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry	202
Metabolic and epigenetic regulation of T-cell exhaustion	200
Fructose stimulated de novo lipogenesis is promoted by inflammation	187
Metabolic Messengers: tumour necrosis factor	182
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	180
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels	173
Exercise hormone irisin is a critical regulator of cognitive function	153
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19	144
Metabolic Messengers: FGF21	142
Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report	141
Dihydroxyacetone phosphate signals glucose availability to mTORC1	137
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade	130
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction	123
The gut microbial metabolite formate exacerbates colorectal cancer progression	119

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	114
Central and peripheral GLP-1 systems independently suppress eating	113
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours	111
Interleukin 6 as an energy allocator in muscle tissue	111
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma	110
Selenium detoxification is required for cancer-cell survival	105
Metabolic communication during exercise	102
Molecular consequences of SARS-CoV-2 liver tropism	99
Mitochondrial pyruvate carriers are required for myocardial stress adaptation	97
GTTs and ITTs in mice: simple tests, complex answers	97
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms	95
The ins and outs of serine and glycine metabolism in cancer	93
POMC neuronal heterogeneity in energy balance and beyond: an integrated view	92
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy	92
Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality	91
Space-time logic of liver gene expression at sub-lobular scale	90
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice	89
UCP1 governs liver extracellular succinate and inflammatory pathogenesis	89
Can COVID-19 cause diabetes?	89
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice	87
Metabolic Messengers: glucagon-like peptide 1	85
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes	84
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy	83
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer	83
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study	83
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	83
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms	82
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis	82
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism	81
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	81
Metabolic Messengers: bile acids	80
Analyzing cell-type-specific dynamics of metabolism in kidney repair	77
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress	77
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding	74
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities	72
Central anorexigenic actions of bile acids are mediated by TGR5	72
Central nervous system regulation of organismal energy and glucose homeostasis	72
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils	72
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function	71
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age	70
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution	69
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes	69
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity	69
Nuclear metabolism and the regulation of the epigenome	69
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes	68
Metabolic regulation of skeletal cell fate and function in physiology and disease	68
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells	68
A genetic map of the mouse dorsal vagal complex and its role in obesity	68
Mitochondrial heterogeneity and homeostasis through the lens of a neuron	68
Defining the lineage of thermogenic perivascular adipose tissue	68

KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth	67
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling	67
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes	67
Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication	67
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans	66
Revisiting energy expenditure: how to correct mouse metabolic rate for body mass	66
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation	64
Effects of maternal and paternal exercise on offspring metabolism	64
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth	63
Exercise and cardiac health: physiological and molecular insights	63
Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue	63
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA	62
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	62
A researcher’s guide to preclinical mouse NASH models	61
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity	61
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes	60
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution	59
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism	58
N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation	58
Profound and redundant functions of arcuate neurons in obesity development	57
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes	57
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice	56
DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes	55
Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle	55
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance	55
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity	55
Metabolic remodelling during early mouse embryo development	54
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	54
Postprandial glycaemic dips predict appetite and energy intake in healthy individuals	53
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	52
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	52
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice	52
CAR-based therapies: opportunities for immuno-medicine beyond cancer	51
Mice as experimental models for human physiology: when several degrees in housing temperature matter	50
The pentose phosphate pathway in health and disease	49
Reciprocal regulation of cellular mechanics and metabolism	49
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model	49
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075	49
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth	49
Systemic induction of senescence in young mice after single heterochronic blood exchange	48
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	48
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions	48
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	48
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers	47
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health	46
A large-scale genome–lipid association map guides lipid identification	45
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination	45
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites	44
TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis	44
Introducing the Lipidomics Minimal Reporting Checklist	44
Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming	44
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases	44
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes	44
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation	43
A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements	43
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	43
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	42
Human plasma proteomic profiles indicative of cardiorespiratory fitness	42
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	42
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	42
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages	42
Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation	41
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation	41
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan	41
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity	40
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity	40
Secretin activates brown fat and induces satiation	40
Innate metabolic responses against viral infections	40
Altered propionate metabolism contributes to tumour progression and aggressiveness	40
Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas	40
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	40
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease	39
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages	39
TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response	39
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia	38
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells	38
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	38
Tetracyclines promote survival and fitness in mitochondrial disease models	38
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex	38
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism	38

BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16	38
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	37
Human metabolome variation along the upper intestinal tract	37
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome	37
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding	37
The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress	37
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development	37
Physiological and pathological roles of lipogenesis	37
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	37
Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly	37
Principles and functions of metabolic compartmentalization	36
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	36
Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics	36
Methionine synthase is essential for cancer cell proliferation in physiological folate environments	36
Quantitative flux analysis in mammals	36
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited	36
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma	36
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	36
Mind your media	35
Angiocrine polyamine production regulates adiposity	35
Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness	35
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation	35
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation	35
Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise	35
A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila	35
Genetics of extreme human longevity to guide drug discovery for healthy ageing	35
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice	34
An orthogonal metabolic framework for one-carbon utilization	34
Polyamine pathway activity promotes cysteine essentiality in cancer cells	34
Consequences of the COVID-19 pandemic for patients with metabolic diseases	34
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity	33
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment	33
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease	33
Age-related loss of gene-to-gene transcriptional coordination among single cells	32
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth	32
Hindbrain circuits in the control of eating behaviour and energy balance	32
Methionine synthase supports tumour tetrahydrofolate pools	32
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation	32
A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures	32
Exercise and immunometabolic regulation in cancer	31
Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals	31
STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure	31
white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila	31
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK	31
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization	31
Circulating metabolite homeostasis achieved through mass action	31
PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages	31
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	31
Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity	31
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity	31
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding	30
Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats	30
Characterization of the genetic architecture of infant and early childhood body mass index	30
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	30
AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury	29
Metabolome modulation of the host adaptive immunity in human malaria	29
The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets	29
Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect	29
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation	29
Sex differences in the intergenerational inheritance of metabolic traits	29
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family	29