OOIR: Observatory of International Research

Papers

(The TQCC of Nature Metabolism is 57. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
Microbial regulation of organismal energy homeostasis	255
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans	222
Leptin and the endocrine control of energy balance	187
Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types	169
A network of trans-cortical capillaries as mainstay for blood circulation in long bones	168
Cardiac glycosides are broad-spectrum senolytics	160
Metabolic signatures of cancer cells and stem cells	151
Metabolic adaptation and maladaptation in adipose tissue	150
Molecular logic of mTORC1 signalling as a metabolic rheostat	148
Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control	147
NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism	142
Slc12a8 is a nicotinamide mononucleotide transporter	127
Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss	119
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis	118
Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy	111
Metabolic Messengers: adiponectin	107
Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis	105
Metabolic Messengers: ceramides	104
m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes	102
Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis	102
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo	99
Lipidomics needs more standardization	97
Inter-organ cross-talk in metabolic syndrome	93
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism	92
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction	87
An upper limit on Gibbs energy dissipation governs cellular metabolism	87
Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour	86
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity	85
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation	84
Spatial sorting enables comprehensive characterization of liver zonation	82
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation	76
Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution	73
Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice	72
Voltage-energized calcium-sensitive ATP production by mitochondria	68
Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation	65
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin	65
MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage	64
Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox?	60
Integrating the inputs that shape pancreatic islet hormone release	58
Liver macrophages regulate systemic metabolism through non-inflammatory factors	58
An artificial intelligence decision support system for the management of type 1 diabetes	57