Nature Metabolism

Article	Citations
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	1064
Glycolysis modulates efferocytosis in a noncanonical manner	452
The cell cycle loops UTP around CAD	399
NAD kinase essentiality in cancer: in real life, it is all about folates	371
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	370
The rs1421085 variant within FTO promotes brown fat thermogenesis	246
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	229
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	228
Phagocytosis in the retina promotes local insulin production in the eye	217
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	175
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	173
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	168
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	168
Incretin-based therapeutics for the treatment of neurodegenerative diseases	162
The cyclic metabolic switching theory of intermittent fasting	155
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	153
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	153
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	149
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	149
Hot news about temperature and lifespan	148
A BCAA–haem axis regulates brown fat function	142
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	141
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	140
The antitumour effects of caloric restriction are mediated by the gut microbiome	139
Shaping the future of cardiometabolic innovation: advances and opportunities	137

A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	133
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	131
Hypermetabolism and energetic constraints in mitochondrial disorders	129
Best practices in collecting and reporting continuous glucose monitoring data in research settings	129
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	129
Fuelling the fire: de novo lipogenesis primes thermogenesis	127
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	127
The thyroid gland under Notch control	122
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	120
TKT deficiency puts Tregs to rest	120
Gut bacteria thwart the blood sugar-lowering effect of acarbose	120
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	119
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	118
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	115
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	114
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	113
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	111
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	108
Spatial metabolomics: from a niche field towards a driver of innovation	106
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	101
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	101
Fuelling synapses via lipid metabolism	98
Querying stool for dietary information	96
Methionine and H2S alter cancer–immune dialogue	95
Why a good lab website matters	95
Hypometabolism with the speed of ultrasound	94
A RalA between high-fat diet and mitochondrial shape	94
Illuminating the ‘healthy obese’ phenotype	93
A systematic mutational framework for studying oxidative phosphorylation-related proteins	93
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	93
Proline fuels ILC3s to maintain gut health	93
Gases define redox signalling: NO, H2S, O2 … and cyanide	90
Sweet signals for myelin: glucose sensing redirected to regeneration	89
Mitochondrial RNA stimulates beige adipocyte development in young mice	89
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	88
A century of the Warburg effect	87
Beyond Warburg: LDHA activates RAC for tumour growth	87
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	86
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	86
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	84
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	84
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	83
Fat sensory cues in early life program central response to food and obesity	83
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	82
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	82
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	81
A researcher’s guide to preclinical mouse NASH models	79
Neurometabolism in focus	79
An integrated single-cell islet atlas in health and disease	78
Human basal metabolic rate has declined over the past 30 years	78

Lighting up targets of dual agonist therapies for diabetes and obesity	75
Cancer metabolite blunts immunity	75
Asters: rising stars in the cholesterol universe	73
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	73
Central regulation of the anorexigenic receptor GFRAL	72
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	71
GLP-2 attenuates antipsychotics’ adverse metabolic effects	71
Feeding the hippocampus … with specific nutrients	71
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	70
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	70
Mapping the plasma metabolome to human health and disease in 274,241 adults	70
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	70
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	70
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	69
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease	69
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	69
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	68
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	66
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	66
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	66
Insulin induces insulin receptor degradation in the liver through EphB4	65
Itaconate boosts type I IFN response by disrupting cytoprotection	64
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	64
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	64
Principles and functions of metabolic compartmentalization	64
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	64
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	63
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function	63
TM6SF2 as new intestinal lipid player	62
Do not overlook the role of fructose in obesity	62
MCT1 helps brown fat suck up succinate	60
Proteogenomic mapping sets stage for precision medicine	60
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	60
A common framework for mouse hypothalamic cell atlases	60
Career pathways, part 12	59
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	58
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	58
Iron at the intersection of macrophage–adipocyte interactions	58
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	58
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	58
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	58
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	57
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	56
A food-sensitive olfactory circuit drives anticipatory satiety	56
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	56
Bile acid binds heart failure and inflammation	56
NAD+ precursor supplementation in human ageing: clinical evidence and challenges	55
Systemic proteome adaptions to 7-day complete caloric restriction in humans	55
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	55
Career pathways, part 9	54
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	53
Anaplerosis in action	53
NAD+ regeneration drives cancer cell proliferation	52
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	51
Revisiting the role of serine metabolism in hepatic lipogenesis	51
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	51
Differential mechanisms affecting weight loss and weight loss maintenance	51
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	51
Mitochondrial function and phenotype are defined by bioenergetics	51
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	51
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	50
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	50
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	49
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	49
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	49
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	49
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	48
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	48
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	48
Metabolic Messengers: itaconate	47
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	47
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	47
Liraglutide restores impaired associative learning in individuals with obesity	47
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	47
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	47
Pentose phosphate pathway drives vascular maturation	46
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	46
A multi-omic trip through the human gut	45
Science in times of conflict	45
Adipose glutaminolysis resurfaces in metabolic disease	45

Disrupting cholesterol homeostasis in T cells boosts antitumour responses	44
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	44
Vestibular nucleus mediation of motion sickness has implications for obesity control	44
A derivative of the ancient drug salicylate for obesity treatment	44
Signalling from adipose tissue to the brain is not just about leptin	44
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	44
Overlooked confounding in studies of metabolite salts	44
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	44
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	43
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	43
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	43
Mitochondrial NAD+ drives liver regeneration	42
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	42
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	42
Phenotypic profiling of solute carriers characterizes serine transport in cancer	42
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	41
Activation of GPR81 by lactate drives tumour-induced cachexia	41
Obesity-induced inflammation: connecting the periphery to the brain	41
SERPINA3C as a mediator of metabolic health in offspring	40
A local source of insulin protects the retina against starvation	40
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	40
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	40
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD	40
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	40
The insulin signalling network	40
Raising the bar for sex and gender reporting in research	40
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome	40
GAPDH redox redux—rewiring pentose phosphate flux	40
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	40
Considerations for designing and analysing inter-generational studies in rodents	39
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	39
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	39
A brief guide to statistical analysis of grouped data in preclinical research	39
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	38
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	38
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	38
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans	38
Metabolic Messengers: endocannabinoids	38
Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age	38
Mitochondrial DNA editing with mitoARCUS	38
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	38
H2S as a metabolic saboteur	38
Subcellular quantitative imaging of metabolites at the organelle level	38
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	37
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	37
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	37
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	37
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	37
Reawakening cAMP signalling in cancer cachexia	37
Cancer tissue of origin constrains the growth and metabolism of metastases	37
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	37
Serine synthesis promotes bone degradation	36
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	36
Itaconate trims the fat	36
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	36
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	36
Innate metabolic responses against viral infections	36
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	35
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass	35
Triglycerides are an important fuel reserve for synapse function in the brain	35
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	34
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	34
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	34
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	34
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	34
Artificial intelligence in metabolic research	34
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	33
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	33
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	33
Actionable targets to reduce COVID-19 severity	33
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	33
Metabolic engineering for optimized CAR-T cell therapy	33
Five years on	33
Gut–liver highway of ALDH2 in drinking	33
Epitranscriptomics in metabolic disease	33
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	33
Mitochondrial superoxide regulates pro-inflammatory macrophages	33
Long-term exercise training has positive effects on adipose tissue in overweight or obesity	32
Human metabolome variation along the upper intestinal tract	32
Metabolic Messengers: ketone bodies	32
Author Correction: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	32
Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism	32
METLIN-CCS Lipid Database: An authentic standards resource for lipid classification and identification	32
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities	32
Histone butyrylation is a dietary link to epigenetics	32
Publisher Correction: A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis	32
Interleukin-17 as a key player in neuroimmunometabolism	32
A dedicated recycling bin keeps muscle healthy	32
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome	31
A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures	31
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition	31
Career pathways, part 7	31
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance	31
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics	31
Anticancer action of caloric restrictions via microbiota	31