Nature Metabolism

Article	Citations
Run to survive—how preoperative exercise could prevent major surgical complications	783
Glycolysis modulates efferocytosis in a noncanonical manner	451
The cell cycle loops UTP around CAD	393
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	310
Phagocytosis in the retina promotes local insulin production in the eye	299
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	281
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	269
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	268
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	219
The rs1421085 variant within FTO promotes brown fat thermogenesis	194
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	193
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	189
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	185
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	179
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	169
Incretin-based therapeutics for the treatment of neurodegenerative diseases	155
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	139
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	138
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	136
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	127
The cyclic metabolic switching theory of intermittent fasting	125
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	125
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	117
A BCAA–haem axis regulates brown fat function	115
Hot news about temperature and lifespan	113

Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	113
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	109
Hypermetabolism and energetic constraints in mitochondrial disorders	108
Best practices in collecting and reporting continuous glucose monitoring data in research settings	107
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	106
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	104
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	104
TKT deficiency puts Tregs to rest	103
The thyroid gland under Notch control	101
Fuelling the fire: de novo lipogenesis primes thermogenesis	101
Gut bacteria thwart the blood sugar-lowering effect of acarbose	100
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	100
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	99
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	98
Spatial metabolomics: from a niche field towards a driver of innovation	97
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	95
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	95
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	93
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	90
Illuminating the ‘healthy obese’ phenotype	89
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	89
The antitumour effects of caloric restriction are mediated by the gut microbiome	89
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis	88
Proline fuels ILC3s to maintain gut health	87
Methionine and H2S alter cancer–immune dialogue	87
Mitochondrial RNA stimulates beige adipocyte development in young mice	87
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	85
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	84
Gases define redox signalling: NO, H2S, O2 … and cyanide	84
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	83
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	83
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	82
Querying stool for dietary information	81
Why a good lab website matters	80
A systematic mutational framework for studying oxidative phosphorylation-related proteins	78
Hypometabolism with the speed of ultrasound	77
A RalA between high-fat diet and mitochondrial shape	76
Beyond Warburg: LDHA activates RAC for tumour growth	76
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	74
A century of the Warburg effect	73
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	73
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	72
A researcher’s guide to preclinical mouse NASH models	71
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	71
Cancer metabolite blunts immunity	70
Neurometabolism in focus	70
An integrated single-cell islet atlas in health and disease	68
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	68
Feeding the hippocampus … with specific nutrients	67
Asters: rising stars in the cholesterol universe	67

Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	67
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	67
Human basal metabolic rate has declined over the past 30 years	67
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	66
Central regulation of the anorexigenic receptor GFRAL	66
TiPpIng the balance in histone acetylation	64
Fixing lymphatics improves glucose metabolism	63
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR	62
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	62
Itaconate boosts type I IFN response by disrupting cytoprotection	61
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	61
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	61
GLP-2 attenuates antipsychotics’ adverse metabolic effects	60
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	60
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function	60
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	59
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	59
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	59
Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity	59
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	58
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	58
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	58
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	58
Insulin induces insulin receptor degradation in the liver through EphB4	58
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	57
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	57
Principles and functions of metabolic compartmentalization	57
Do not overlook the role of fructose in obesity	56
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	56
TM6SF2 as new intestinal lipid player	56
A common framework for mouse hypothalamic cell atlases	54
Nuclear PHGDH protects cancer cells from nutrient stress	54
Proteogenomic mapping sets stage for precision medicine	54
MCT1 helps brown fat suck up succinate	54
Career pathways, part 12	53
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	53
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	53
Iron at the intersection of macrophage–adipocyte interactions	53
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes	53
Bile acid binds heart failure and inflammation	53
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	53
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	52
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	52
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	52
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	51
Systemic proteome adaptions to 7-day complete caloric restriction in humans	51
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	51
NAD+ regeneration drives cancer cell proliferation	50
Mitochondrial function and phenotype are defined by bioenergetics	50
Revisiting the role of serine metabolism in hepatic lipogenesis	50
Anaplerosis in action	49
Career pathways, part 9	49
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	48
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	48
Differential mechanisms affecting weight loss and weight loss maintenance	48
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	48
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	48
Plasticity and heterogeneity of thermogenic adipose tissue	48
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	48
Liraglutide restores impaired associative learning in individuals with obesity	47
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	47
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	47
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	47
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	47
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	47
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	46
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	46
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	45
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	45
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	45
Metabolic Messengers: itaconate	45
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	45
Overlooked confounding in studies of metabolite salts	44
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	43
Adipose glutaminolysis resurfaces in metabolic disease	43
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	42
Publisher Correction: A new foe in folate metabolism	42
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	42
A multi-omic trip through the human gut	42
GAPDH redox redux—rewiring pentose phosphate flux	42

Umami taste—a novel mechanism driving food intake and obesity	42
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	41
Pentose phosphate pathway drives vascular maturation	41
Science in times of conflict	41
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	40
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	39
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	38
Quantitative flux analysis in mammals	38
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	38
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	38
Signalling from adipose tissue to the brain is not just about leptin	38
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	38
Vestibular nucleus mediation of motion sickness has implications for obesity control	37
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	37
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	37
Activation of GPR81 by lactate drives tumour-induced cachexia	36
Phenotypic profiling of solute carriers characterizes serine transport in cancer	36
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	36
A blood-to-brain delivery system to treat obesity	35
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	35
Raising the bar for sex and gender reporting in research	35
Obesity-induced inflammation: connecting the periphery to the brain	35
SERPINA3C as a mediator of metabolic health in offspring	35
A local source of insulin protects the retina against starvation	35
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	34
H2S as a metabolic saboteur	34
Mitochondrial DNA editing with mitoARCUS	34
Metabolic Messengers: endocannabinoids	33
Considerations for designing and analysing inter-generational studies in rodents	33
Subcellular quantitative imaging of metabolites at the organelle level	33
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	33
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	33
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	32
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family	32
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	32
Cancer tissue of origin constrains the growth and metabolism of metastases	32
Human plasma proteomic profiles indicative of cardiorespiratory fitness	32
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	32
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	31
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	31
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	31
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development	31
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	31
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	31
Itaconate trims the fat	30
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	30
What about sex?	30
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass	30
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	30
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection	30
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	30
Serine synthesis promotes bone degradation	30
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	30
Innate metabolic responses against viral infections	30
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	29
Metabolic engineering for optimized CAR-T cell therapy	29
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	29
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	29
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	29
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	29
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	28
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	28
Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states	28
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	28
Epitranscriptomics in metabolic disease	28
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	28
Considering co-submissions	27
Interleukin-17 as a key player in neuroimmunometabolism	27
Publisher Correction: A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis	27
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance	27
Mitochondrial superoxide regulates pro-inflammatory macrophages	27
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities	27
Actionable targets to reduce COVID-19 severity	27
Five years on	27
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics	27
Metabolic Messengers: ketone bodies	27
A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures	27
Author Correction: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	26
Author Correction: Human plasma proteomic profiles indicative of cardiorespiratory fitness	26
METLIN-CCS Lipid Database: An authentic standards resource for lipid classification and identification	26
Anticancer action of caloric restrictions via microbiota	26
Gut–liver highway of ALDH2 in drinking	26
Long-term exercise training has positive effects on adipose tissue in overweight or obesity	26
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition	26
Human metabolome variation along the upper intestinal tract	26
Histone butyrylation is a dietary link to epigenetics	26
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome	26
Career pathways, part 7	26
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target	25
The cellular states and fates of shed intestinal cells	25
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study	25
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation	25
CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake	25
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression	25
Lipid fuel for hungry-angry microglia	25