Nature Metabolism

Article	Citations
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo	545
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals	407
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas	394
Gut microbiome pattern reflects healthy ageing and predicts survival in humans	350
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism	322
Lipolysis: cellular mechanisms for lipid mobilization from fat stores	297
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection	281
The metabolic roots of senescence: mechanisms and opportunities for intervention	275
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages	233
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry	213
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	212
Metabolic Messengers: tumour necrosis factor	210
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels	188
Exercise hormone irisin is a critical regulator of cognitive function	169
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction	155
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19	153
Metabolic Messengers: FGF21	149
The gut microbial metabolite formate exacerbates colorectal cancer progression	144
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	131
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma	130
Interleukin 6 as an energy allocator in muscle tissue	127
Central and peripheral GLP-1 systems independently suppress eating	122
GTTs and ITTs in mice: simple tests, complex answers	105
Molecular consequences of SARS-CoV-2 liver tropism	103
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms	103

The ins and outs of serine and glycine metabolism in cancer	99
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice	99
Mitochondrial pyruvate carriers are required for myocardial stress adaptation	99
Metabolic Messengers: glucagon-like peptide 1	98
POMC neuronal heterogeneity in energy balance and beyond: an integrated view	98
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice	96
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	95
Space-time logic of liver gene expression at sub-lobular scale	95
Metabolic Messengers: bile acids	94
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis	93
UCP1 governs liver extracellular succinate and inflammatory pathogenesis	93
Can COVID-19 cause diabetes?	93
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes	90
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	89
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism	87
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study	86
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer	86
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy	86
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress	86
Analyzing cell-type-specific dynamics of metabolism in kidney repair	84
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils	81
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function	79
Mitochondrial heterogeneity and homeostasis through the lens of a neuron	78
Central nervous system regulation of organismal energy and glucose homeostasis	78
Defining the lineage of thermogenic perivascular adipose tissue	78
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding	78
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution	77
Nuclear metabolism and the regulation of the epigenome	77
KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth	76
A researcher’s guide to preclinical mouse NASH models	76
Central anorexigenic actions of bile acids are mediated by TGR5	76
The pentose phosphate pathway in health and disease	75
Metabolic regulation of skeletal cell fate and function in physiology and disease	75
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling	75
A genetic map of the mouse dorsal vagal complex and its role in obesity	75
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes	75
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities	75
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity	75
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes	73
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells	72
Revisiting energy expenditure: how to correct mouse metabolic rate for body mass	71
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans	71
Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication	71
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	71
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation	70
Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue	69
N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation	69
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth	68
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism	68
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution	68

Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity	67
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA	65
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	65
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	64
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth	63
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes	61
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice	61
Metabolic remodelling during early mouse embryo development	60
CAR-based therapies: opportunities for immuno-medicine beyond cancer	60
Mitophagy in human health, ageing and disease	59
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	58
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	57
Postprandial glycaemic dips predict appetite and energy intake in healthy individuals	57
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance	57
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	56
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice	55
Physiological and pathological roles of lipogenesis	55
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity	55
Reciprocal regulation of cellular mechanics and metabolism	54
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination	53
TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis	53
Systemic induction of senescence in young mice after single heterochronic blood exchange	53
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites	52
Mice as experimental models for human physiology: when several degrees in housing temperature matter	52
Innate metabolic responses against viral infections	52
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	51
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	51
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075	51
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages	51
Human metabolome variation along the upper intestinal tract	51
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions	51
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	50
Introducing the Lipidomics Minimal Reporting Checklist	50
Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas	50
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes	50
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers	50
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages	49
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health	49
Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming	49
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model	49
A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements	49
Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation	47
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity	47
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases	46
Human plasma proteomic profiles indicative of cardiorespiratory fitness	46
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	46
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	45
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	44
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16	44
Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity	44
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation	44
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome	44
TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response	44
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation	44
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding	43
PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages	43
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	43
Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan	43
Altered propionate metabolism contributes to tumour progression and aggressiveness	43
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism	43
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease	42
Methionine synthase is essential for cancer cell proliferation in physiological folate environments	42
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex	42
Secretin activates brown fat and induces satiation	42
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation	41
A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures	41
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition	41
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma	41
Angiocrine polyamine production regulates adiposity	41
Principles and functions of metabolic compartmentalization	41
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells	40
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth	40
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	40
Tetracyclines promote survival and fitness in mitochondrial disease models	40
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	40
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development	39
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited	39
GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia	39
Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness	39
Quantitative flux analysis in mammals	39

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets	39
Hindbrain circuits in the control of eating behaviour and energy balance	38
Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease	38
Mind your media	38
A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila	38
The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress	38
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	38
Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics	38
The antitumour effects of caloric restriction are mediated by the gut microbiome	38
Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly	37
Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound	37
Characterization of the genetic architecture of infant and early childhood body mass index	37
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity	37
Lysosomal control of senescence and inflammation through cholesterol partitioning	36
Consequences of the COVID-19 pandemic for patients with metabolic diseases	36
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding	36
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	36
Gut hormone co-agonists for the treatment of obesity: from bench to bedside	36
An orthogonal metabolic framework for one-carbon utilization	36
Methionine synthase supports tumour tetrahydrofolate pools	35
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	35
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment	35
Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals	35
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity	35
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization	34
Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis	34
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	34
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation	34
Triglyceride cycling enables modification of stored fatty acids	34
Sex differences in the intergenerational inheritance of metabolic traits	34
Circulating metabolite homeostasis achieved through mass action	33
The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells	33
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family	33
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions	33
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	33
Age-related loss of gene-to-gene transcriptional coordination among single cells	33
A century of the Warburg effect	33
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK	32
Dynamic lipidome alterations associated with human health, disease and ageing	32
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH	32
white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila	32
STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure	32
PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy	31
Intestinal MYC modulates obesity-related metabolic dysfunction	31
Metabolome modulation of the host adaptive immunity in human malaria	31
High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption	31
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	31
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia	30
Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity	30
Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	30
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation	30
The metabolic growth limitations of petite cells lacking the mitochondrial genome	29
Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity	29
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis	29
Mammary epithelial cells have lineage-rooted metabolic identities	29
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation	29
PKC downregulation upon rapamycin treatment attenuates mitochondrial disease	29
Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect	29
An electrogenetic interface to program mammalian gene expression by direct current	28
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages	28
Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits	28
Spatial discordances between mRNAs and proteins in the intestinal epithelium	28
Plasticity and heterogeneity of thermogenic adipose tissue	27
Food-seeking behavior is triggered by skin ultraviolet exposure in males	27
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype	27
Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice	27
Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice	27
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2	27
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	27
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis	26
Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation	26
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings	26
PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation	26
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing	26
The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions	26
Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response	25
Spatial metabolomics: from a niche field towards a driver of innovation	25
Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism	25
Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance	25
The SESAME complex regulates cell senescence through the generation of acetyl-CoA	25
Ketone bodies for the starving heart	25
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	24
MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion	24
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate	24
Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma	24
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR	24
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	24
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL	23
Metabolic reconfiguration enables synthetic reductive metabolism in yeast	23
SIRT2 regulates extracellular vesicle-mediated liver–bone communication	23
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	23
A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila	22
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma	22
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis	22
Targeting pancreatic β cells for diabetes treatment	22