OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 76. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Incretin-based therapeutics for the treatment of neurodegenerative diseases	992
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	555
Glycolysis modulates efferocytosis in a noncanonical manner	401
The cell cycle loops UTP around CAD	368
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	358
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	326
NAD kinase essentiality in cancer: in real life, it is all about folates	315
The cyclic metabolic switching theory of intermittent fasting	232
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	232
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	212
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	201
Phagocytosis in the retina promotes local insulin production in the eye	200
The rs1421085 variant within FTO promotes brown fat thermogenesis	177
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	154
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	153
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	148
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	147
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	145
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	144
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	143
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	141
Hot news about temperature and lifespan	138
A BCAA–haem axis regulates brown fat function	137
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	134
Best practices in collecting and reporting continuous glucose monitoring data in research settings	127

Fuelling the fire: de novo lipogenesis primes thermogenesis	127
The thyroid gland under Notch control	127
Gut bacteria thwart the blood sugar-lowering effect of acarbose	126
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	121
TKT deficiency puts Tregs to rest	121
Shaping the future of cardiometabolic innovation: advances and opportunities	119
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	119
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	118
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	116
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	113
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	113
Spatial metabolomics: from a niche field towards a driver of innovation	110
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	108
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	107
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	106
Hypermetabolism and energetic constraints in mitochondrial disorders	106
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	106
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	104
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	103
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	101
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	100
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	97
The antitumour effects of caloric restriction are mediated by the gut microbiome	97
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	94
Fuelling synapses via lipid metabolism	92
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	91
Gases define redox signalling: NO, H2S, O2 … and cyanide	91
Proline fuels ILC3s to maintain gut health	90
Why a good lab website matters	90
Querying stool for dietary information	90
Beyond Warburg: LDHA activates RAC for tumour growth	88
A RalA between high-fat diet and mitochondrial shape	86
Hypometabolism with the speed of ultrasound	86
A systematic mutational framework for studying oxidative phosphorylation-related proteins	85
Methionine and H2S alter cancer–immune dialogue	85
Illuminating the ‘healthy obese’ phenotype	85
Sweet signals for myelin: glucose sensing redirected to regeneration	83
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	82
Mitochondrial RNA stimulates beige adipocyte development in young mice	82
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	82
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	82
A century of the Warburg effect	82
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	80
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	79
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	79
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	78
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	78
A researcher’s guide to preclinical mouse NASH models	78
Neurometabolism in focus	77
An integrated single-cell islet atlas in health and disease	77

Human basal metabolic rate has declined over the past 30 years