OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	639
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	408
Author Correction: Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase	391
Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	354
Author Correction: Activation of GPR81 by lactate drives tumour-induced cachexia	322
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	287
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	240
Activation of GPR81 by lactate drives tumour-induced cachexia	228
Cellular and organismal function of choline metabolism	193
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	190
Co-receptor regulation of insulin signaling	168
Alkaline taste sensation through the alkaliphile chloride channel in Drosophila	164
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas	153
mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1	149
Astrocytic GABA in LHA is an obesity ‘thermostat’	142
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	134
The pressure not to eat	131
Obesity impairs brain responses to nutrients	113
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue	110
BCAT2–BCKDH metabolon maintains BCAA homeostasis	110
The dance of gut microbes on the keto diet	105
Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges	103
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis	102
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding	99
Phenotypic profiling of solute carriers characterizes serine transport in cancer	98

Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	98
The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions	97
Gut microbiome-derived ammonia modulates stress vulnerability in the host	96
Broad-spectrum antibiotics disrupt homeostatic efferocytosis	95
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	94
Linking neuropsychiatric disease to neuronal metabolism	93
Lipids reroute mitochondria	89
HDAC6 inhibition overcomes leptin resistance in obesity	89
Gut reaction: it’s not all about enzymes	87
nicX-ing bad habits with your microbial friends	86
The cell cycle loops UTP around CAD	85
Virtually unsocial	84
Hippo STK kinases drive metabolic derangement	84
A call for accessible tools to unlock single-cell immunometabolism research	83
Run to survive—how preoperative exercise could prevent major surgical complications	83
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	82
Umami taste—a novel mechanism driving food intake and obesity	81
Pentose phosphate pathway drives vascular maturation	80
Malaria thriving on steroids	80
Overlooked confounding in studies of metabolite salts	79
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	78
There is more than one way to reach type 2 diabetes	78
Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation	77
Science in times of conflict	77
MOF moves into mitochondria	77
Adipose glutaminolysis resurfaces in metabolic disease	75
Hypothalamus pre-optic area and metabolism regulation in humans	75
A multi-omic trip through the human gut	74
Impaired cell surface expression of GLP1R variants determines T2D and obesity risk in humans	74
Glycolysis modulates efferocytosis in a noncanonical manner	72
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	71
GTTs and ITTs: aim for shorter fasting times	71
Time of exercise differentially impacts bone growth in mice	70
Intestinal plasticity and metabolism as regulators of organismal energy homeostasis	70
STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure	69
Independent phenotypic plasticity axes define distinct obesity sub-types	69
Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness	68
Human PERIOD3 variants lead to winter depression-like behaviours via glucocorticoid signalling	67
PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity	67
ACBP orchestrates the metabolic phenotype in Cushing’s syndrome	66
Author Correction: PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity	66