OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 76. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	1029
Glycolysis modulates efferocytosis in a noncanonical manner	423
The cell cycle loops UTP around CAD	383
NAD kinase essentiality in cancer: in real life, it is all about folates	371
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	347
The cyclic metabolic switching theory of intermittent fasting	344
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	242
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	240
The rs1421085 variant within FTO promotes brown fat thermogenesis	220
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	220
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	211
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	184
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	164
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	161
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	160
Phagocytosis in the retina promotes local insulin production in the eye	159
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	156
Incretin-based therapeutics for the treatment of neurodegenerative diseases	149
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	148
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	147
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	144
Hot news about temperature and lifespan	141
A BCAA–haem axis regulates brown fat function	139
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	137
Fuelling the fire: de novo lipogenesis primes thermogenesis	135

Best practices in collecting and reporting continuous glucose monitoring data in research settings	133
The thyroid gland under Notch control	128
TKT deficiency puts Tregs to rest	128
Gut bacteria thwart the blood sugar-lowering effect of acarbose	128
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	126
Shaping the future of cardiometabolic innovation: advances and opportunities	125
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	124
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	122
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	119
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	118
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	115
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	115
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	115
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	113
Hypermetabolism and energetic constraints in mitochondrial disorders	112
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	111
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	111
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	110
Spatial metabolomics: from a niche field towards a driver of innovation	109
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	106
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	103
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	101
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	95
The antitumour effects of caloric restriction are mediated by the gut microbiome	94
Fuelling synapses via lipid metabolism	93
Querying stool for dietary information	92
Hypometabolism with the speed of ultrasound	92
Why a good lab website matters	92
A RalA between high-fat diet and mitochondrial shape	91
A systematic mutational framework for studying oxidative phosphorylation-related proteins	90
A century of the Warburg effect	89
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	89
Illuminating the ‘healthy obese’ phenotype	89
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	88
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	88
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	84
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	84
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	84
Gases define redox signalling: NO, H2S, O2 … and cyanide	83
Sweet signals for myelin: glucose sensing redirected to regeneration	83
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	83
Mitochondrial RNA stimulates beige adipocyte development in young mice	83
Proline fuels ILC3s to maintain gut health	83
Methionine and H2S alter cancer–immune dialogue	83
Beyond Warburg: LDHA activates RAC for tumour growth	82
A researcher’s guide to preclinical mouse NASH models	81
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	78
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	78
Fat sensory cues in early life program central response to food and obesity	78
Neurometabolism in focus	78

Human basal metabolic rate has declined over the past 30 years	76
An integrated single-cell islet atlas in health and disease	76
Cancer metabolite blunts immunity	76