OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 70. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo	545
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals	407
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas	394
Gut microbiome pattern reflects healthy ageing and predicts survival in humans	350
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism	322
Lipolysis: cellular mechanisms for lipid mobilization from fat stores	297
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection	281
The metabolic roots of senescence: mechanisms and opportunities for intervention	275
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages	233
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry	213
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	212
Metabolic Messengers: tumour necrosis factor	210
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels	188
Exercise hormone irisin is a critical regulator of cognitive function	169
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction	155
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19	153
Metabolic Messengers: FGF21	149
The gut microbial metabolite formate exacerbates colorectal cancer progression	144
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	131
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma	130
Interleukin 6 as an energy allocator in muscle tissue	127
Central and peripheral GLP-1 systems independently suppress eating	122
GTTs and ITTs in mice: simple tests, complex answers	105
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms	103
Molecular consequences of SARS-CoV-2 liver tropism	103

Mitochondrial pyruvate carriers are required for myocardial stress adaptation	99
The ins and outs of serine and glycine metabolism in cancer	99
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice	99
POMC neuronal heterogeneity in energy balance and beyond: an integrated view	98
Metabolic Messengers: glucagon-like peptide 1	98
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice	96
Space-time logic of liver gene expression at sub-lobular scale	95
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	95
Metabolic Messengers: bile acids	94
UCP1 governs liver extracellular succinate and inflammatory pathogenesis	93
Can COVID-19 cause diabetes?	93
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis	93
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes	90
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	89
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism	87
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy	86
Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress	86
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study	86
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer	86
Analyzing cell-type-specific dynamics of metabolism in kidney repair	84
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils	81
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function	79
Defining the lineage of thermogenic perivascular adipose tissue	78
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding	78
Mitochondrial heterogeneity and homeostasis through the lens of a neuron	78
Central nervous system regulation of organismal energy and glucose homeostasis	78
Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution	77
Nuclear metabolism and the regulation of the epigenome	77
Central anorexigenic actions of bile acids are mediated by TGR5	76
KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth	76
A researcher’s guide to preclinical mouse NASH models	76
A genetic map of the mouse dorsal vagal complex and its role in obesity	75
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes	75
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities	75
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity	75
The pentose phosphate pathway in health and disease	75
Metabolic regulation of skeletal cell fate and function in physiology and disease	75
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling	75
Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes	73
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells	72
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans	71
Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication	71
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	71
Revisiting energy expenditure: how to correct mouse metabolic rate for body mass	71
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation	70