OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The cell cycle loops UTP around CAD	1237
Incretin-based therapeutics for the treatment of neurodegenerative diseases	545
Phagocytosis in the retina promotes local insulin production in the eye	490
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	479
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	476
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	281
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	247
PFKM governs metabolic shifts throughout skeletal muscle differentiation	209
NAD kinase essentiality in cancer: in real life, it is all about folates	209
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	196
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	188
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	186
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	184
The cyclic metabolic switching theory of intermittent fasting	183
The rs1421085 variant within FTO promotes brown fat thermogenesis	177
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	174
Epigenetic adaptation of beta cells across lifespan and disease	172
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	170
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	164
DGAT1 mediates sex-specific CD8+ T cell antitumour responses	162
Glycolysis modulates efferocytosis in a noncanonical manner	159
Heterogeneous sympathetic control of brown adipose tissue	153
Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum	151
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	150
A BCAA–haem axis regulates brown fat function	146

A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	146
Fuelling the fire: de novo lipogenesis primes thermogenesis	141
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	141
Methylation, acetylation and cell fate	141
Shaping the future of cardiometabolic innovation: advances and opportunities	137
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	137
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	134
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	133
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	130
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	128
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	126
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	121
Hypermetabolism and energetic constraints in mitochondrial disorders	117
The thyroid gland under Notch control	116
Gut bacteria thwart the blood sugar-lowering effect of acarbose	115
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	115
TKT deficiency puts Tregs to rest	114
Best practices in collecting and reporting continuous glucose monitoring data in research settings	114
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	113
The antitumour effects of caloric restriction are mediated by the gut microbiome	113
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	108
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	108
Spatial metabolomics: from a niche field towards a driver of innovation	107
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	106
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	106
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	104
Why a good lab website matters	101
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	100
Fat sensory cues in early life program central response to food and obesity	99
Hypometabolism with the speed of ultrasound	98
A RalA between high-fat diet and mitochondrial shape	98
A systematic mutational framework for studying oxidative phosphorylation-related proteins	97
Querying stool for dietary information	97
Gases define redox signalling: NO, H2S, O2 … and cyanide	97
Sweet signals for myelin: glucose sensing redirected to regeneration	97
Beyond Warburg: LDHA activates RAC for tumour growth	96
Proline fuels ILC3s to maintain gut health	95
Fuelling synapses via lipid metabolism	94
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance	94
Illuminating the ‘healthy obese’ phenotype	93
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	92
Methionine and H2S alter cancer–immune dialogue	92
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	92
Mitochondrial RNA stimulates beige adipocyte development in young mice	92
A century of the Warburg effect	87
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	87
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	87
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	86
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	85
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	84

A researcher’s guide to preclinical mouse NASH models	83
Neurometabolism in focus	82
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	82
An integrated single-cell islet atlas in health and disease	81
Cancer metabolite blunts immunity	80