OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
NAD kinase essentiality in cancer: in real life, it is all about folates	596
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	581
Glycolysis modulates efferocytosis in a noncanonical manner	579
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice	533
Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum	310
Epigenetic adaptation of beta cells across lifespan and disease	262
Heterogeneous sympathetic control of brown adipose tissue	244
Phagocytosis in the retina promotes local insulin production in the eye	239
The cyclic metabolic switching theory of intermittent fasting	221
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	218
Incretin-based therapeutics for the treatment of neurodegenerative diseases	215
Author Correction: Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy	215
Author Correction: SLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth	199
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	194
Exercise and glucagon-like peptide 1 receptor agonists in cardiovascular disease beyond weight loss	192
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	190
PFKM governs metabolic shifts throughout skeletal muscle differentiation	182
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	180
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	177
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	175
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	166
The rs1421085 variant within FTO promotes brown fat thermogenesis	164
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	162
The cell cycle loops UTP around CAD	156
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	156

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	153
DGAT1 mediates sex-specific CD8+ T cell antitumour responses	152
A BCAA–haem axis regulates brown fat function	148
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	147
Methylation, acetylation and cell fate	143
Fuelling the fire: de novo lipogenesis primes thermogenesis	140
Gut bacteria thwart the blood sugar-lowering effect of acarbose	135
The thyroid gland under Notch control	135
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	134
Best practices in collecting and reporting continuous glucose monitoring data in research settings	132
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	129
Shaping the future of cardiometabolic innovation: advances and opportunities	127
Cellular loci for cagrilintide action identified	125
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	124
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	123
Hypermetabolism and energetic constraints in mitochondrial disorders	123
The antitumour effects of caloric restriction are mediated by the gut microbiome	122
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	121
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	119
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	117
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	114
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	112
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	110
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	110
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	107
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	107
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	107
Mitochondrial RNA stimulates beige adipocyte development in young mice	106
Spatial metabolomics: from a niche field towards a driver of innovation	106
Why a good lab website matters	106
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	106
Fuelling synapses via lipid metabolism	104
Fat sensory cues in early life program central response to food and obesity	103
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	103
Hypometabolism with the speed of ultrasound	101
A RalA between high-fat diet and mitochondrial shape	100
A systematic mutational framework for studying oxidative phosphorylation-related proteins	99
Sweet signals for myelin: glucose sensing redirected to regeneration	98
Querying stool for dietary information	96
Illuminating the ‘healthy obese’ phenotype	94
Methionine and H2S alter cancer–immune dialogue	94
Gases define redox signalling: NO, H2S, O2 … and cyanide	92
Beyond Warburg: LDHA activates RAC for tumour growth	91
A century of the Warburg effect	91
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	90
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	87
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis	86
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	86
A researcher’s guide to preclinical mouse NASH models	86
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	86

Cysteine depletion triggers adipose tissue thermogenesis and weight loss	85
Proline fuels ILC3s to maintain gut health	85
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance	85
An integrated single-cell islet atlas in health and disease	84
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	84
Lighting up targets of dual agonist therapies for diabetes and obesity	83
Cancer metabolite blunts immunity	83
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	82
Asters: rising stars in the cholesterol universe	82