OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The cell cycle loops UTP around CAD	1275
NAD kinase essentiality in cancer: in real life, it is all about folates	563
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	516
Glycolysis modulates efferocytosis in a noncanonical manner	513
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	498
The rs1421085 variant within FTO promotes brown fat thermogenesis	292
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	253
Epigenetic adaptation of beta cells across lifespan and disease	219
Heterogeneous sympathetic control of brown adipose tissue	213
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	203
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	200
DGAT1 mediates sex-specific CD8+ T cell antitumour responses	195
PFKM governs metabolic shifts throughout skeletal muscle differentiation	192
Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum	189
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	188
The cyclic metabolic switching theory of intermittent fasting	180
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	177
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	174
Incretin-based therapeutics for the treatment of neurodegenerative diseases	173
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	167
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	163
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	157
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice	153
Phagocytosis in the retina promotes local insulin production in the eye	151
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	151

A BCAA–haem axis regulates brown fat function	150
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	148
Fuelling the fire: de novo lipogenesis primes thermogenesis	145
Methylation, acetylation and cell fate	145
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	140
The thyroid gland under Notch control	140
The antitumour effects of caloric restriction are mediated by the gut microbiome	137
Gut bacteria thwart the blood sugar-lowering effect of acarbose	137
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	134
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	134
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	129
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	127
Shaping the future of cardiometabolic innovation: advances and opportunities	123
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	121
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	118
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	117
Hypermetabolism and energetic constraints in mitochondrial disorders	117
Spatial metabolomics: from a niche field towards a driver of innovation	116
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	115
Best practices in collecting and reporting continuous glucose monitoring data in research settings	115
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	112
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	112
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	111
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	111
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	108
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	108
Why a good lab website matters	104
Fat sensory cues in early life program central response to food and obesity	103
Hypometabolism with the speed of ultrasound	102
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	102
A RalA between high-fat diet and mitochondrial shape	101
A systematic mutational framework for studying oxidative phosphorylation-related proteins	101
Querying stool for dietary information	100
Sweet signals for myelin: glucose sensing redirected to regeneration	100
Illuminating the ‘healthy obese’ phenotype	97
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance	97
Proline fuels ILC3s to maintain gut health	97
Methionine and H2S alter cancer–immune dialogue	97
Mitochondrial RNA stimulates beige adipocyte development in young mice	96
Beyond Warburg: LDHA activates RAC for tumour growth	95
Gases define redox signalling: NO, H2S, O2 … and cyanide	95
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	95
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	92
A century of the Warburg effect	91
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	90
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	90
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis	89
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	88
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	87
A researcher’s guide to preclinical mouse NASH models	87

Fuelling synapses via lipid metabolism	86
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	85
Neurometabolism in focus	84
An integrated single-cell islet atlas in health and disease	83
Lighting up targets of dual agonist therapies for diabetes and obesity	82
Cancer metabolite blunts immunity	82
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	81
Asters: rising stars in the cholesterol universe	81