OOIR: Observatory of International Research

Papers

(The TQCC of Geroscience is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	118
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	72
The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age	66
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	63
Proceedings from the annual University of Washington Geroscience Symposium, October 23, 2020	53
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	51
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	51
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation	50
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	48
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands	48
Learning from machine learning: prediction of age-related athletic performance decline trajectories	43
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	41
Generation and characterization of a tractable C. elegans model of tauopathy	41
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	41
Greater habitual moderate-to-vigorous physical activity is associated with better executive function and higher prefrontal oxygenation in older adults	40
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	38
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain	38
T lymphocyte depletion ameliorates age-related metabolic impairments in mice	37
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary	37
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells	36
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components	36
Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary	36
HIV, pathology and epigenetic age acceleration in different human tissues	36
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume	36
Familial aggregation of the aging process: biological age measured in young adult offspring as a predictor of parental mortality	36

Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing	35
University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging	35
Epigenetic clock and methylation studies in vervet monkeys	34
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle	34
A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer’s disease brains	33
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	33
Longitudinal course of GDF15 levels before acute hospitalization and death in the general population	33
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	33
University of Southern California and buck institute nathan shock center: multidimensional models of aging	33
The Nathan Shock Centers	33
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	32
Use of convalescent plasma therapy in hospitalised adult patients with non-critical COVID-19: a focus on the elderly from Hungary	32
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	32
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	32
Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome	32
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	31
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	31
Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells	31
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	30
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	28
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	28
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	28
Obesity paradox in joint replacement for osteoarthritis — truth or paradox?	28
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging	28
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease	28
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	28
DNA damage-induced degradation of Sp1 promotes cellular senescence	28
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	28
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	27
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	27
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males	26
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	26
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	26
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	25
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries	25
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability	24
Alterations in the estrogen receptor profile of cardiovascular tissues during aging	24
The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction	23
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	23
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	23
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	22
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	22
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	22
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	22
Correction to: Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	21
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	21
Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	21
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	21
Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD	21
Are the 50’s, the transition decade, in choroid plexus aging?	20

Vitamin D supplementation is associated with slower epigenetic aging	20
Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment	20
Epigenetic clock and methylation studies in the rhesus macaque	20
Liver frailty and all-cause mortality in the older participants of the Salus in Apulia Study	19
Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer’s disease	19
A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response	19
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	19
Evidence for preserved insulin responsiveness in the aging rat brain	19
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	19
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus	19
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	19
Higher-order resting state network association with the useful field of view task in older adults	19
Effect of longevity genetic variants on the molecular aging rate	19
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?	18
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	18
50 years of the “war on cancer”: lessons for public health and geroscience	18
Cardiac response to adrenergic stress differs by sex and across the lifespan	18
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	18
Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a	17
Lipid and metabolite correlation networks specific to clinical and biochemical covariate show differences associated with sexual dimorphism in a cohort of nonagenarians	17
Serological and viral genetic features of patients with COVID-19 in a selected German patient cohort—correlation with disease characteristics	17
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	17
Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans	17
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	17
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats	17
Old plasma dilution reduces human biological age: a clinical study	17
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	17