OOIR: Observatory of International Research

Papers

(The TQCC of Geroscience is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	107
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	98
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	81
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	79
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	69
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	59
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	58
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	58
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	57
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	56
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	55
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	52
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	52
Evidence for preserved insulin responsiveness in the aging rat brain	51
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	50
Vitamin D supplementation is associated with slower epigenetic aging	50
Senolytic treatment rescues blunted muscle hypertrophy in old mice	50
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	49
Fast and slow skeletal myosin binding protein-C and aging	48
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	46
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	46
Lipidomic signatures from physically frail and robust older adults at hospital admission	46
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	43
Prediction of disability-free survival in healthy older people	43
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	42

Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	41
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	41
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	39
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	39
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	39
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	38
Is “cellular senescence” a misnomer?	38
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	37
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	37
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring	36
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	36
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	36
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	36
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	35
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	35
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	35
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	34
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	33
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	31
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	30
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	30
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	30
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	30
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	29
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	29
Longitudinal association of executive function and structural network controllability in the aging brain	29
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	29
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	29
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	28
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	28
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	28