OOIR: Observatory of International Research

Papers

(The TQCC of Geroscience is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	255
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	101
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	93
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	81
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	78
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	66
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	66
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	64
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	58
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	57
Vitamin D supplementation is associated with slower epigenetic aging	56
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	56
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	55
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	55
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	54
Senolytic treatment rescues blunted muscle hypertrophy in old mice	52
Evidence for preserved insulin responsiveness in the aging rat brain	50
Fast and slow skeletal myosin binding protein-C and aging	49
Lipidomic signatures from physically frail and robust older adults at hospital admission	49
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	49
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	48
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	47
Prediction of disability-free survival in healthy older people	47
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	46
The aging venous system: from varicosities to vascular cognitive impairment	46

Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	44
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	43
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	41
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	41
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	40
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	39
Is “cellular senescence” a misnomer?	39
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	38
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	37
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	37
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	37
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	37
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	36
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	36
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	35
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	35
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring	35
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	34
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	34
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	34
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	34
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	32
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	31
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	31
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	29
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	29
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	29
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	29
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	29
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	29
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	28
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	28
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	28
Longitudinal association of executive function and structural network controllability in the aging brain	28
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	27
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	27
Elevated skin senescence in young mice causes delayed wound healing	27
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	27