OOIR: Observatory of International Research

Papers

(The TQCC of Geroscience is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes	345
Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss	206
Effect of rapamycin on aging and age-related diseases—past and future	115
The effect of social distance measures on COVID-19 epidemics in Europe: an interrupted time series analysis	109
Severe COVID-19 and aging: are monocytes the key?	104
COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches	101
Increase in blood–brain barrier leakage in healthy, older adults	97
The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging	86
Regulation of senescence traits by MAPKs	82
Novel coronavirus epidemic in the Hungarian population, a cross-sectional nationwide survey to support the exit policy in Hungary	67
Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis	67
Retinal biomarkers for Alzheimer’s disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis	67
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries	64
Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans	59
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge	56
Intermittent fasting: from calories to time restriction	50
Does SARS-CoV-2 infection cause chronic neurological complications?	49
Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition	49
Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues	48
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	45
Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress	42
Regulation of TDP-43 phosphorylation in aging and disease	42
Nursing homes and the elderly regarding the COVID-19 pandemic: situation report from Hungary	41
Imaging the role of blood–brain barrier disruption in normal cognitive ageing	41
Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice	40

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats	38
Aging alters acetylation status in skeletal and cardiac muscles	37
Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration	37
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	36
Companion animals likely do not spread COVID-19 but may get infected themselves	36
Plasma dilution improves cognition and attenuates neuroinflammation in old mice	36
Mitochondrial-derived peptides in aging and age-related diseases	35
Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study	35
Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors	34
IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging	33
Necroptosis increases with age in the brain and contributes to age-related neuroinflammation	32
Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer’s disease	32
Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regions	32
Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats	32
An energetics perspective on geroscience: mitochondrial protonmotive force and aging	32
The impact of immuno-aging on SARS-CoV-2 vaccine development	31
Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging	31
Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype	31
A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson’s disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study	31
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts	31
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers	30
Senescent cell accumulation mechanisms inferred from parabiosis	30
A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin	30
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	29
Quest for a summary measure of biological age: the health and retirement study	29
Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study	28
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats	28
Brain angiotensin II and angiotensin IV receptors as potential Alzheimer’s disease therapeutic targets	28
Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review	28
Analysis of complexity in the EEG activity of Parkinson’s disease patients by means of approximate entropy	27
Epigenetic clock and methylation studies in the rhesus macaque	27
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	27
Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults	27
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males	27
A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor	27
Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics	27
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	27
Correction to: SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes	26
Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats	26
The aging venous system: from varicosities to vascular cognitive impairment	26
Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span	25
Mapping the multicausality of Alzheimer’s disease through group model building	25
Senolytic treatment rescues blunted muscle hypertrophy in old mice	25
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain	25
Senescent macrophages in the human adipose tissue as a source of inflammaging	25
Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems	25
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	24
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?	24
Epigenetic clock and methylation studies in cats	24
Obesity as a premature aging phenotype — implications for sarcopenic obesity	24

A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved	24
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	24
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	24
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	23
Poor mitochondrial health and systemic inflammation? Test of a classic hypothesis in the Baltimore Longitudinal Study of Aging	23
DNA methylation age analysis of rapamycin in common marmosets	23
Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner	23
Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis	23
Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney	23
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	22
Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity	22
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19	22
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?	22
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia	22
Patterns of multi-domain cognitive aging in participants of the Long Life Family Study	22
Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study	21
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study	21
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells	21
Angiotensin (1–7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats	21
Effects of sleep deprivation on endothelial function in adult humans: a systematic review	20
Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment	20
Biomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s Disease Neuroimaging Initiative	20
Role of B cells and the aging brain in stroke recovery and treatment	20
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	20
Fasting and fasting-mimicking diets for chemotherapy augmentation	20
Greater habitual moderate-to-vigorous physical activity is associated with better executive function and higher prefrontal oxygenation in older adults	20
Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin	19
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model	19
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	19
Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity	19
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus	19
Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies	19
Current perspectives on the clinical implications of oxidative RNA damage in aging research: challenges and opportunities	19
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume	19
Plasma exosomes characterization reveals a perioperative protein signature in older patients undergoing different types of on-pump cardiac surgery	18
Traumatic brain injury-induced cerebral microbleeds in the elderly	18
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	18
High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice	18
Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions	18
Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults	18
A short life on the farm: aging and longevity in agricultural, large-bodied mammals	18
The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases	17
Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation	17
Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease	17
Alterations in the estrogen receptor profile of cardiovascular tissues during aging	17
Prefrontal cortex activation during dual-task walking in older adults is moderated by thickness of several cortical regions	17
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging	17
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length	17
Brain cellular senescence in mouse models of Alzheimer’s disease	17
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing	17
Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins	17
Handgrip strength—a risk indicator for future fractures in the general population: findings from a prospective study and meta-analysis of 19 prospective cohort studies	17
A short digital eye-tracking assessment predicts cognitive status among adults	17
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study	17
Characterization of the plasma proteomic profile of frailty phenotype	16
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	16
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	16
“Cerebral small vessel disease and other influential factors of cognitive impairment in the middle-aged: a long-term observational cohort PURE-MIND study in Poland”	16
eIF4E phosphorylation modulates pain and neuroinflammation in the aged	16
Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques	16
Morbidity compression or expansion? A temporal analysis of the age at onset of non-communicable diseases in India	16
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	16