Geroscience

Article	Citations
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge	99
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries	72
Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans	63
Intermittent fasting: from calories to time restriction	63
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	53
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	51
Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice	50
Regulation of TDP-43 phosphorylation in aging and disease	48
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	48
Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review	46
Plasma dilution improves cognition and attenuates neuroinflammation in old mice	46
IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging	41
Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration	41
Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype	41
Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors	40
Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats	38
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males	37
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	36
Analysis of complexity in the EEG activity of Parkinson’s disease patients by means of approximate entropy	36
Senescent macrophages in the human adipose tissue as a source of inflammaging	36
Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regions	36
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts	36
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	35
Quest for a summary measure of biological age: the health and retirement study	35
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	35

Necroptosis increases with age in the brain and contributes to age-related neuroinflammation	35
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers	35
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	34
Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study	34
Obesity as a premature aging phenotype — implications for sarcopenic obesity	34
Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study	33
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain	33
Senolytic treatment rescues blunted muscle hypertrophy in old mice	33
An energetics perspective on geroscience: mitochondrial protonmotive force and aging	33
Epigenetic clock and methylation studies in the rhesus macaque	32
A naturally hypersensitive porcine model may help understand the mechanism of COVID-19 mRNA vaccine-induced rare (pseudo) allergic reactions: complement activation as a possible contributing factor	32
Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults	32
Senescent cell accumulation mechanisms inferred from parabiosis	32
The aging venous system: from varicosities to vascular cognitive impairment	32
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?	32
The impact of immuno-aging on SARS-CoV-2 vaccine development	31
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	31
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	30
Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics	30
Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults	29
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	29
Effects of sleep deprivation on endothelial function in adult humans: a systematic review	28
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?	28
DNA methylation age analysis of rapamycin in common marmosets	28
The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases	28
Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney	28
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	28
A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved	28
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells	28
Biomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s Disease Neuroimaging Initiative	27
Epigenetic clock and methylation studies in cats	27
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling	27
Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies	26
Fasting and fasting-mimicking diets for chemotherapy augmentation	25
Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis	25
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	25
Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions	25
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study	25
Alterations in the estrogen receptor profile of cardiovascular tissues during aging	24
Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner	24
Greater habitual moderate-to-vigorous physical activity is associated with better executive function and higher prefrontal oxygenation in older adults	23
Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment	23
The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction	23
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19	23
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus	23
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model	22
Plant-based diets and risk of frailty in community-dwelling older adults: the Seniors-ENRICA-1 cohort	22
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study	21
Role of heat shock proteins in aging and chronic inflammatory diseases	21
Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice	21

Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	21
Neurovascular-glymphatic dysfunction and white matter lesions	21
Elevated skin senescence in young mice causes delayed wound healing	21
Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation	21
Morbidity compression or expansion? A temporal analysis of the age at onset of non-communicable diseases in India	21
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary	21
Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease	20
Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease	20
Brain cellular senescence in mouse models of Alzheimer’s disease	20
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length	20
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing	20
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	19
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	19
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	19
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume	19
Characterization of the plasma proteomic profile of frailty phenotype	19
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	19
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	19
Prefrontal cortex activation during dual-task walking in older adults is moderated by thickness of several cortical regions	19
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components	19
Approximate entropy analysis across electroencephalographic rhythmic frequency bands during physiological aging of human brain	19
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	19
The majority of severe COVID-19 patients develop anti-cardiac autoantibodies	18
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	18
Henipaviruses: an expanding global public health concern?	18
Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins	18
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	18
The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor	17
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	17
Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women	17
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	17
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice	17
HIV, pathology and epigenetic age acceleration in different human tissues	17
Cognitive decrement in older adults with symptomatic peripheral artery disease	17
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	17
Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer’s disease	17
Is “cellular senescence” a misnomer?	17
Cardiovascular risk prediction in healthy older people	17
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	16
A ride through the epigenetic landscape: aging reversal by reprogramming	16
Selective brain regional changes in lipid profile with human aging	16
Epigenetic clock and methylation studies in vervet monkeys	16
Association between psychological resilience and cognitive function in older adults: effect modification by inflammatory status	16
Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts	16
Cell-to-cell variation in gene expression and the aging process	16
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	16
The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification	16
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes	16
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease	16
Resistance exercise intervention on muscular strength and power, and functional capacity in acute hospitalized older adults: a systematic review and meta-analysis of 2498 patients in 7 randomized clin	15
Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin	15
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	15
Vitamin D supplementation is associated with slower epigenetic aging	15
The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study	15
Reversal of cerebral hypoperfusion: a novel therapeutic target for the treatment of AD/ADRD?	15
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease	15
Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease	15
Metabolic syndrome and Growth Differentiation Factor 15 in older adults	15
Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study	15
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study	15
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study	15
Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients	15
T lymphocyte depletion ameliorates age-related metabolic impairments in mice	15
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	14
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	14
IL-6 can singlehandedly drive many features of frailty in mice	14
Dual effects of insulin resistance on mortality and function in non-diabetic older adults: findings from the Toledo Study of Healthy Aging	14
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	14
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	14
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain	14
Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia	14
DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes	14
Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study	14
Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study	14
Cardiac response to adrenergic stress differs by sex and across the lifespan	14
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	14
Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis	14
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	14
Slowing down as we age: aging of the cardiac pacemaker’s neural control	14
Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project	14

Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats	14
Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD	14
Older age, male sex, and cerebral microbleeds predict white matter loss after traumatic brain injury	13
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	13
Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization	13
ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging	13
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	13
Prediction of disability-free survival in healthy older people	13
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	13
The relative contributions of behavioral, biological, and psychological risk factors in the association between psychosocial stress and all-cause mortality among middle- and older-aged adults in the U	12
Strategies and cognitive reserve to preserve lexical production in aging	12
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands	12
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment	12
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	12
Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease	12
Effect of longevity genetic variants on the molecular aging rate	12
Liver frailty and all-cause mortality in the older participants of the Salus in Apulia Study	12
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	12
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	12
Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats	12
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	12
A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response	12
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	12
Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function	12
Circulating fatty acids and endocannabinoidome-related mediator profiles associated to human longevity	12
Age-related neuroendocrine and alerting responses to light	11
Therapeutic prevention of COVID-19 in elderly: a case–control study	11
Aerobic fitness is inversely associated with neurohemodynamic transduction and blood pressure variability in older adults	11
Aging, stress, and senescence in plants: what can biological diversity teach us?	11
SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa	11
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	11
Increased procoagulant platelet levels are predictive of death in COVID-19	11
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	11
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	11
Implication of post-translationally modified SOD1 in pathological aging	11
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	11
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability	11
Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age	11
The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as novel anti-aging compound	11
Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan	11
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	11
Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men	11
Old plasma dilution reduces human biological age: a clinical study	11
Longitudinal association of executive function and structural network controllability in the aging brain	10
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	10
Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)	10
Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet	10
Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation	10
White matter hyperintensity load varies depending on subjective cognitive decline criteria	10
Association between telomere length, frailty and death in older adults	10
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	10
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	10
New imaging tools for mouse models of osteoarthritis	10
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment	10
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	10
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	10
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	10
How size and genetic diversity shape lifespan across breeds of purebred dogs	10
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study	10
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	10
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries	10