OOIR: Observatory of International Research

Papers

(The median citation count of Geroscience is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	141
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	133
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	85
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	67
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	64
Fast and slow skeletal myosin binding protein-C and aging	62
Evidence for preserved insulin responsiveness in the aging rat brain	62
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	61
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	53
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	52
Is “cellular senescence” a misnomer?	49
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	45
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	44
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	41
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	40
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	39
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	37
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	37
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	36
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	35
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	34
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	34
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	34
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	34
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	33

Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	32
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	32
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	31
Longitudinal association of executive function and structural network controllability in the aging brain	31
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	30
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	30
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	29
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	27
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	26
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer	25
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	25
Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI	23
A metabolomic signature of the APOE2 allele	22
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	22
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	21
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	20
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	20
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	20
Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity	19
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	19
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	19
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	19
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults	19
Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus	19
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment	18
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	18
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age	18
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	18
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity	18
How size and genetic diversity shape lifespan across breeds of purebred dogs	17
Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing	17
Microbiota mitochondria disorders as hubs for early age-related macular degeneration	17
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle	16
The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction	16
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?	16