Geroscience

Article	Citations
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	173
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	79
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	78
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	71
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	68
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	68
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	67
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	57
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	56
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	55
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	52
Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer’s disease	48
Lipid and metabolite correlation networks specific to clinical and biochemical covariate show differences associated with sexual dimorphism in a cohort of nonagenarians	47
Eat like an athlete: insights of sports nutrition science to support active aging in healthy older adults	47
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	47
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	47
Vitamin D supplementation is associated with slower epigenetic aging	47
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	47
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	47
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue	45
Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study	43
Evidence for preserved insulin responsiveness in the aging rat brain	43
Senolytic treatment rescues blunted muscle hypertrophy in old mice	43
Lipidomic signatures from physically frail and robust older adults at hospital admission	42
Fast and slow skeletal myosin binding protein-C and aging	42

Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	42
Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease	41
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	41
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	41
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study	40
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	40
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	39
The aging venous system: from varicosities to vascular cognitive impairment	39
Prediction of disability-free survival in healthy older people	38
Acute-care hospital reencounters in COVID-19 patients	36
Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	36
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	36
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	35
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	35
Slowing down as we age: aging of the cardiac pacemaker’s neural control	34
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	33
Is “cellular senescence” a misnomer?	33
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	33
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	32
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	32
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	31
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	31
Pterocarpus marsupium extract extends replicative lifespan in budding yeast	31
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring	30
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	30
DNA methylation age analysis of rapamycin in common marmosets	30
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	29
Prefrontal cortex activation during dual-task walking in older adults is moderated by thickness of several cortical regions	28
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	28
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	28
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	28
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	28
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	27
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	27
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	27
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	26
Epigenetic clock and methylation studies in vervet monkeys	26
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	26
University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging	25
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	25
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	24
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	24
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	24
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	24
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	23
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	23
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	23
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	23
Liver frailty and all-cause mortality in the older participants of the Salus in Apulia Study	22
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	22

Longitudinal association of executive function and structural network controllability in the aging brain	22
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	22
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	22
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	22
Higher-order resting state network association with the useful field of view task in older adults	22
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	21
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	21
Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment	21
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	21
Are fat and sugar just as detrimental in old age?	21
Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach	21
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	20
Senescent macrophages in the human adipose tissue as a source of inflammaging	20
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	20
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	20
Elevated skin senescence in young mice causes delayed wound healing	20
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	20
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting	20
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	20
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	20
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	19
Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast	19
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	19
Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson’s disease focusing on correlations with motor symptoms	19
Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors	19
Favipiravir treatment does not influence disease progression among adult patients hospitalized with moderate-to-severe COVID-19: a prospective, sequential cohort study from Hungary	19
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers	19
San Antonio Nathan Shock Center: your one-stop shop for aging research	19
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	19
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	19
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes	19
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	19
The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification	18
Correction to: Effect of longevity genetic variants on the molecular aging rate	18
Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells	18
The understudied links of the retromer complex to age-related pathways	18
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer	18
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration	17
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	17
The elderly at risk: aldosterone as modulator of the immune response to SARS-CoV-2 infection	17
Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project	17
Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span	17
A metabolomic signature of the APOE2 allele	17
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	17
Resistance exercise intervention on muscular strength and power, and functional capacity in acute hospitalized older adults: a systematic review and meta-analysis of 2498 patients in 7 randomized clin	17
Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults	17
Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging	17
Correction to: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	17
Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI	17
Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men	17
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	16
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	16
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	16
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	15
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging	15
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	15
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	15
Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men	15
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	15
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	15
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	15
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patients	15
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	15
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	15
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	15
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	15
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	14
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	14
Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs	14
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment	14
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	14
Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy	14
Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus	14
The AGE Presents Introduction to Geroscience video lecture series	14
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	14
Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice	13
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults	13
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain	13
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	13
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	13

Man’s best friend in life and death: scientific perspectives and challenges of dog brain banking	13
Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype	13
Dual effects of insulin resistance on mortality and function in non-diabetic older adults: findings from the Toledo Study of Healthy Aging	13
Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity	13
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?	12
Therapeutic prevention of COVID-19 in elderly: a case–control study	12
Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing	12
Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis	12
How size and genetic diversity shape lifespan across breeds of purebred dogs	12
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age	12
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study	12
Increased procoagulant platelet levels are predictive of death in COVID-19	12
The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study	12
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment	12
Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function	12
Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults	12
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	12
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity	12
University of Southern California and buck institute nathan shock center: multidimensional models of aging	12
Microbiota mitochondria disorders as hubs for early age-related macular degeneration	12