OOIR: Observatory of International Research

Papers

(The median citation count of Geroscience is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	232
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	90
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	81
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	81
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	76
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	72
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	61
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	61
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	59
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	57
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	55
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	54
Senolytic treatment rescues blunted muscle hypertrophy in old mice	54
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	52
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	50
Evidence for preserved insulin responsiveness in the aging rat brain	50
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	49
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	48
Vitamin D supplementation is associated with slower epigenetic aging	48
Fast and slow skeletal myosin binding protein-C and aging	47
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	46
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	46
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	46
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	46
Lipidomic signatures from physically frail and robust older adults at hospital admission	46

Prediction of disability-free survival in healthy older people	43
The aging venous system: from varicosities to vascular cognitive impairment	43
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study	43
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	42
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	40
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	39
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	38
Is “cellular senescence” a misnomer?	38
Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	38
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	38
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	38
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	36
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	36
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	35
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	35
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	35
DNA methylation age analysis of rapamycin in common marmosets	35
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	35
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring	34
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	34
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	33
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	32
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	32
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	32
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	32
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	32
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	31
Epigenetic clock and methylation studies in vervet monkeys	30
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	30
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	29
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	29
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	29
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	28
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	28
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	28
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	28
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	27
Longitudinal association of executive function and structural network controllability in the aging brain	27
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	27
Elevated skin senescence in young mice causes delayed wound healing	26
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	25
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	25
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	25
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting	24
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	24
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	24
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	24
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	24
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	24
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	23

Senescent macrophages in the human adipose tissue as a source of inflammaging	23
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	23
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	23
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	23
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	23
Favipiravir treatment does not influence disease progression among adult patients hospitalized with moderate-to-severe COVID-19: a prospective, sequential cohort study from Hungary	22
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers	22
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes	22
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	22
Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast	22
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	22
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer	21
Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults	21
Correction to: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	21
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	21
Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson’s disease focusing on correlations with motor symptoms	21
Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men	20
A metabolomic signature of the APOE2 allele	20
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	20
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration	20
Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI	20
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	19
The elderly at risk: aldosterone as modulator of the immune response to SARS-CoV-2 infection	19
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	19
Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project	19
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	18
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	18
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	18
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	18
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	18
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	18
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	18
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	18
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	18
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patients	17
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment	17
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	17
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	17
Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs	17
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	17
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	17
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	17
Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy	17
Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus	17
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	16
Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults	16
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	16
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain	16
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	16
Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity	16
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study	16
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age	15
The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study	15
Microbiota mitochondria disorders as hubs for early age-related macular degeneration	15
Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing	15
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults	15
Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis	15
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment	15
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity	15
How size and genetic diversity shape lifespan across breeds of purebred dogs	15
Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function	15