Geroscience

Article	Citations
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	118
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	72
The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age	66
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	63
Proceedings from the annual University of Washington Geroscience Symposium, October 23, 2020	53
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	51
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	51
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation	50
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	48
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands	48
Learning from machine learning: prediction of age-related athletic performance decline trajectories	43
Generation and characterization of a tractable C. elegans model of tauopathy	41
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	41
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	41
Greater habitual moderate-to-vigorous physical activity is associated with better executive function and higher prefrontal oxygenation in older adults	40
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	38
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain	38
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary	37
T lymphocyte depletion ameliorates age-related metabolic impairments in mice	37
Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary	36
HIV, pathology and epigenetic age acceleration in different human tissues	36
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume	36
Familial aggregation of the aging process: biological age measured in young adult offspring as a predictor of parental mortality	36
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells	36
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components	36

University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging	35
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing	35
Epigenetic clock and methylation studies in vervet monkeys	34
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle	34
Longitudinal course of GDF15 levels before acute hospitalization and death in the general population	33
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	33
University of Southern California and buck institute nathan shock center: multidimensional models of aging	33
The Nathan Shock Centers	33
A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer’s disease brains	33
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	33
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	32
Use of convalescent plasma therapy in hospitalised adult patients with non-critical COVID-19: a focus on the elderly from Hungary	32
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	32
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	32
Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome	32
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	31
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	31
Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells	31
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	30
Obesity paradox in joint replacement for osteoarthritis — truth or paradox?	28
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging	28
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease	28
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	28
DNA damage-induced degradation of Sp1 promotes cellular senescence	28
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	28
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	28
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	28
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	28
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	27
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	27
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	26
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	26
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males	26
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries	25
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	25
Alterations in the estrogen receptor profile of cardiovascular tissues during aging	24
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability	24
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	23
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	23
The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction	23
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	22
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	22
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	22
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	22
Correction to: Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	21
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	21
Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	21
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	21
Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD	21
Vitamin D supplementation is associated with slower epigenetic aging	20

Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment	20
Epigenetic clock and methylation studies in the rhesus macaque	20
Are the 50’s, the transition decade, in choroid plexus aging?	20
Evidence for preserved insulin responsiveness in the aging rat brain	19
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	19
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus	19
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	19
Higher-order resting state network association with the useful field of view task in older adults	19
Effect of longevity genetic variants on the molecular aging rate	19
Liver frailty and all-cause mortality in the older participants of the Salus in Apulia Study	19
Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer’s disease	19
A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response	19
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	19
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?	18
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	18
50 years of the “war on cancer”: lessons for public health and geroscience	18
Cardiac response to adrenergic stress differs by sex and across the lifespan	18
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	18
Lipid and metabolite correlation networks specific to clinical and biochemical covariate show differences associated with sexual dimorphism in a cohort of nonagenarians	17
Serological and viral genetic features of patients with COVID-19 in a selected German patient cohort—correlation with disease characteristics	17
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	17
Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans	17
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	17
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats	17
Old plasma dilution reduces human biological age: a clinical study	17
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	17
Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a	17
Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice	16
Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension	16
Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats	16
Deletion of Nrip1 delays skin aging by reducing adipose-derived mesenchymal stem cells (ADMSCs) senescence, and maintaining ADMSCs quiescence	16
Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment	16
Eat like an athlete: insights of sports nutrition science to support active aging in healthy older adults	16
Regulation of TDP-43 phosphorylation in aging and disease	16
Plant-based diets and risk of frailty in community-dwelling older adults: the Seniors-ENRICA-1 cohort	16
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	16
Metabolic syndrome and Growth Differentiation Factor 15 in older adults	16
Metabolic pathways and therapeutics to promote resilience, rehabilitation and delayed aging	16
Senolytic treatment rescues blunted muscle hypertrophy in old mice	16
Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum	15
The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults	15
Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata	15
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	15
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	15
Strategies and cognitive reserve to preserve lexical production in aging	15
Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan	15
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	15
Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner	15
Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population	15
Modeling human gray hair by irradiation as a valuable tool to study aspects of tissue aging	15
Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells	15
Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer’s disease and longevity in an Italian population	14
Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study	14
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	14
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	14
Are fat and sugar just as detrimental in old age?	14
Elevated skin senescence in young mice causes delayed wound healing	14
Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach	14
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	14
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task	14
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	14
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	14
The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles	14
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue	14
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries	14
Longitudinal association of executive function and structural network controllability in the aging brain	14
Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids	14
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice	14
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	13
SARS-CoV-2 infection in HIV-infected patients: potential role in the high mutational load of the Omicron variant emerging in South Africa	13
Retraction Note to: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study	13
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study	13
Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients	13
White matter hyperintensity load varies depending on subjective cognitive decline criteria	13
Brain cellular senescence in mouse models of Alzheimer’s disease	13
An energetics perspective on geroscience: mitochondrial protonmotive force and aging	12
Evidence that conserved essential genes are enriched for pro-longevity factors	12
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	12
Divergent regulation of lncRNA expression by ischemia in adult and aging mice	12
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting	12

Inhibition of the 3-mercaptopyruvate sulfurtransferase—hydrogen sulfide system promotes cellular lipid accumulation	12
Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication	12
Fast and slow skeletal myosin binding protein-C and aging	12
Aging: working memory capacity and spatial strategies in a virtual orientation task	12
Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age	12
Epigenetic clock and methylation studies in cats	12
Cell-to-cell variation in gene expression and the aging process	11
University of Washington Nathan Shock Center: innovation to advance aging research	11
Optimising the selection of outcomes for healthy ageing trials: a mixed methods study	11
The Instrumented Stand and Walk (ISAW) test to predict falls in older men	11
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts	11
Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age	11
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model	11
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?	11
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	11
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	11
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	11
Focus group study on perceptions and information needs regarding vaccines targeting the older population: a cross-country comparison in four European countries	11
A long-term obesogenic high-fat diet in mice partially dampens the anti-frailty benefits of late-life intermittent fasting	11
Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice	11
Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men	11
Metabolomics of aging in primary fibroblasts from small and large breed dogs	11
Lipidomic signatures from physically frail and robust older adults at hospital admission	11
The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective	11
Vitamin D3 promotes longevity in Caenorhabditis elegans	11
Cardiovascular risk prediction in healthy older people	11
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	11
Selective brain regional changes in lipid profile with human aging	11
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	10
Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors	10
Pre-frail older adults show improved cognition with StayFitLonger computerized home–based training: a randomized controlled trial	10
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	10
The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor	10
Circulating fatty acids and endocannabinoidome-related mediator profiles associated to human longevity	10
Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study	10
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	10
Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection	10
Senescent macrophages in the human adipose tissue as a source of inflammaging	10
A quantitative yeast aging proteomics analysis reveals novel aging regulators	10
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patients	10
Cognitive control, interference inhibition, and ordering of information during working memory in younger and older healthy adults	10
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	10
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	10
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	10
Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study	10
Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation	10