OOIR: Observatory of International Research

Papers

(The median citation count of Geroscience is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	133
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	128
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	84
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	67
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	64
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	62
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	60
Evidence for preserved insulin responsiveness in the aging rat brain	60
Vitamin D supplementation is associated with slower epigenetic aging	54
Fast and slow skeletal myosin binding protein-C and aging	53
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	52
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	46
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	44
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	43
Is “cellular senescence” a misnomer?	42
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	41
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	39
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	38
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	37
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	36
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	36
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	36
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	35
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	34
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	34

Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	33
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	33
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	33
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	32
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	32
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	31
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	30
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	30
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	30
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	29
Longitudinal association of executive function and structural network controllability in the aging brain	29
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	27
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	27
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	27
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	25
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	25
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	24
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer	23
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	23
Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI	22
A metabolomic signature of the APOE2 allele	22
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	21
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	20
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	20
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	20
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	19
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	19
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	19
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	19
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	19
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	18
Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus	18
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	18
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment	18
Microbiota mitochondria disorders as hubs for early age-related macular degeneration	17
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	17
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity	17
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults	17
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment	17
Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity	17
How size and genetic diversity shape lifespan across breeds of purebred dogs	16
Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing	16
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age	16
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle	15