OOIR: Observatory of International Research

Papers

(The TQCC of SLAS Discovery is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	105
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	69
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	54
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	45
Bioassay protocol metadata annotation: Proposed standards adoption	43
Outline and background for the EU-OS solubility prediction challenge	42
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	37
Protocol for 3D screening of lung cancer spheroids using natural products	36
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	31
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	30
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	30
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	28
Emerging drug discovery ecosystems	27
An efficient and scalable data analysis solution for automated electrophysiology platforms	26
Drug repurposing screen for the rare disease ataxia-telangiectasia	24
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	23
The Impact of Assay Design on Medicinal Chemistry: Case Studies	22
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	21
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	21
Automation of Organoid Cultures: Current Protocols and Applications	21
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	21
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	20
Role Of Vaccines Against COVID-19 Pandemic	19
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	18
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	18

Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	17
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	16
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	16
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	15
Screening for molecular glues – Challenges and opportunities	14
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	13
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	13
In Memoriam	13
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	13
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes	12
Protocol to develop A 3D tumor model for drug testing applications	12
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	12
Screening for modulators of autism spectrum disorder using induced human neurons	12
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	11
High-Throughput cell-based immunofluorescence assays against influenza	11
A perspective on the discovery of enzyme activators	11
Development of a live cell assay for the zinc transporter ZnT8	11
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	10
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	10
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	10
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	10
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	10
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Publisher's Note	8
Creating a more strategic small molecule biophysical hit characterization workflow	8
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	8
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	8
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	8
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	8
A robust CETSA data analysis automation workflow for routine screening	8
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
SLAS Discovery – The Next Generation of Research	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Using chemical and biological data to predict drug toxicity	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	6
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	6
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	6
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	6
Protocols in drug discovery	6

Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	6
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
Characterisation of high throughput screening outputs for small molecule degrader discovery	6
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	6
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	6
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	6
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	6
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	6