OOIR: Observatory of International Research

Papers

(The TQCC of SLAS Discovery is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-12-01 to 2024-12-01.)

Article	Citations
E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones	197
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery	123
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors	61
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2	45
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	41
Cryo-EM: The Resolution Revolution and Drug Discovery	39
High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids	37
Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery	37
High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives	35
Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery	34
Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3	32
Using chemical and biological data to predict drug toxicity	31
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry	30
Identification of Compounds for Butyrylcholinesterase Inhibition	29
Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding	28
Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries	28
CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle–Dependent Degradation of CDK2	27
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19	27
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	26
Target Validation Using PROTACs: Applying the Four Pillars Framework	26
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	25
Small-Molecule Degraders beyond PROTACs—Challenges and Opportunities	25
A Review of the Preclinical and Clinical Efficacy of Remdesivir, Hydroxychloroquine, and Lopinavir-Ritonavir Treatments against COVID-19	24
Comparative Analysis of Multiple Immunoassays for Cytokine Profiling in Drug Discovery	23
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics	22

Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data	22
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex	22
Validating ADME QSAR Models Using Marketed Drugs	22
A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts	22
Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development	21
Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19	20
Lead identification using 3D models of pancreatic cancer	19
ASCT1 and ASCT2: Brother and Sister?	19
A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry	18
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry	18
The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration	18
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors	18
Evaluating Very Deep Convolutional Neural Networks for Nucleus Segmentation from Brightfield Cell Microscopy Images	17
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	17
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput	17
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	16
Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns	16
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	16
waveRAPID—A Robust Assay for High-Throughput Kinetic Screens with the Creoptix WAVEsystem	15
A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids	15
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination	15
COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging Epidemics	15
The Vital Role of Proteomics in Characterizing Novel Protein Degraders	14
Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance	13
Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1–Nrf2 Protein–Protein Interaction	13
The Extensive and Expensive Impacts of HEp-2 [HeLa], Intestine 407 [HeLa], and Other False Cell Lines in Journal Publications	13
Automation of Organoid Cultures: Current Protocols and Applications	13
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target	13
A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities	12
Characterizations of the Urate Transporter, GLUT9, and Its Potent Inhibitors by Patch-Clamp Technique	12
Luminescence Energy Transfer–Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery	12
Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases	12
Optimization of a Colorimetric Assay to Determine Lactate Dehydrogenase B Activity Using Design of Experiments	12
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry	11
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening	11
Operationalizing the Use of Biofabricated Tissue Models as Preclinical Screening Platforms for Drug Discovery and Development	11
Evolution and impact of high content imaging	11
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	11
deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids	11
Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening	10
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	10
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	10
Fragment-based screening: A new paradigm for ligand and target discovery	10
Saporin, a Polynucleotide–Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection	10
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	9
Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling	9
High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ	9
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	9
Mass spectrometry-based proteomics of 3D cell culture: A useful tool to validate culture of spheroids and organoids	9
Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors	8

Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates	8
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	8
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease	8
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR	8
A Solid Supported Membrane-Based Technology for Electrophysical Screening of B0AT1-Modulating Compounds	7
Screening for modulators of autism spectrum disorder using induced human neurons	7
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells	7
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	7
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	7
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1	7
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase rep	7
A perspective on the discovery of enzyme activators	7
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	7
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance	7