OOIR: Observatory of International Research

Papers

(The TQCC of SLAS Discovery is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	163
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	62
Outline and background for the EU-OS solubility prediction challenge	53
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	49
Bioassay protocol metadata annotation: Proposed standards adoption	35
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	33
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	25
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	25
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	24
Protocol for 3D screening of lung cancer spheroids using natural products	23
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	18
Role Of Vaccines Against COVID-19 Pandemic	17
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	17
An efficient and scalable data analysis solution for automated electrophysiology platforms	17
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	16
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	16
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	16
Drug repurposing screen for the rare disease ataxia-telangiectasia	15
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	14
Emerging drug discovery ecosystems	14
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	14
Screening for molecular glues – Challenges and opportunities	14
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	14
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down	13
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	13

Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	12
In Memoriam	12
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	12
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	12
High-Throughput cell-based immunofluorescence assays against influenza	11
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
Development of a live cell assay for the zinc transporter ZnT8	10
Protocol to develop A 3D tumor model for drug testing applications	10
A perspective on the discovery of enzyme activators	10
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	9
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	9
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Creating a more strategic small molecule biophysical hit characterization workflow	9
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	8
Using chemical and biological data to predict drug toxicity	8
Publisher's Note	8
A robust CETSA data analysis automation workflow for routine screening	8
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	7
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	7
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	7
Characterisation of high throughput screening outputs for small molecule degrader discovery	7
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	7
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Binder2030: a quantitative membrane proteome binding dataset enabling AI-driven drug discovery	7
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	7
Protocols in drug discovery	7
High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression	7