OOIR: Observatory of International Research

Papers

(The TQCC of SLAS Discovery is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Outline and background for the EU-OS solubility prediction challenge	176
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	70
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	54
Bioassay protocol metadata annotation: Proposed standards adoption	54
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	40
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	38
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	36
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	26
Protocol for 3D screening of lung cancer spheroids using natural products	25
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	24
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	24
Emerging drug discovery ecosystems	18
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	18
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	17
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	17
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	16
Role Of Vaccines Against COVID-19 Pandemic	16
Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern	16
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	15
Drug repurposing screen for the rare disease ataxia-telangiectasia	15
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	15
Screening for molecular glues – Challenges and opportunities	14
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	14
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down	14
In Memoriam	13

Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	13
Protocol to develop A 3D tumor model for drug testing applications	12
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	12
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	12
High-Throughput cell-based immunofluorescence assays against influenza	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	10
Development of a live cell assay for the zinc transporter ZnT8	10
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites	10
A perspective on the discovery of enzyme activators	10
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	9
A high throughput assay to identify modulators of Death Receptor 3 (DR3)	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
Publisher's Note	9
A robust CETSA data analysis automation workflow for routine screening	9
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	9
SLAS discovery - special issue - biomolecular condensate drug discovery	9
Creating a more strategic small molecule biophysical hit characterization workflow	8
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	8
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	8
Using chemical and biological data to predict drug toxicity	8
Characterisation of high throughput screening outputs for small molecule degrader discovery	7
High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression	7
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	7
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
Protocols in drug discovery	7
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	7
Binder2030: a quantitative membrane proteome binding dataset enabling AI-driven drug discovery	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	7
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7