OOIR: Observatory of International Research

Papers

(The TQCC of SLAS Discovery is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	73
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	64
In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors	46
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	42
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	40
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	37
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	35
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	33
A Quantitative Bioassay to Determine the Inhibitory Potency of NGF–TrkA Antagonists	29
Bioassay protocol metadata annotation: Proposed standards adoption	28
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	27
Protocol for 3D screening of lung cancer spheroids using natural products	26
Outline and background for the EU-OS solubility prediction challenge	26
An efficient and scalable data analysis solution for automated electrophysiology platforms	25
Emerging drug discovery ecosystems	25
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19	24
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	24
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	23
Automation of Organoid Cultures: Current Protocols and Applications	22
The Impact of Assay Design on Medicinal Chemistry: Case Studies	20
Drug repurposing screen for the rare disease ataxia-telangiectasia	20
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	19
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	19
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	19
Role Of Vaccines Against COVID-19 Pandemic	19

Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	18
Screening for molecular glues – Challenges and opportunities	17
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	17
A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities	17
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	16
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	16
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	15
In Memoriam	14
Development of a live cell assay for the zinc transporter ZnT8	13
A perspective on the discovery of enzyme activators	13
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	13
Protocol to develop A 3D tumor model for drug testing applications	13
Screening for modulators of autism spectrum disorder using induced human neurons	12
High-Throughput cell-based immunofluorescence assays against influenza	12
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	11
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes	11
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	11
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	11
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	11
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	10
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
Biochemical and Cellular Profile of NIK Inhibitors with Long Residence Times	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	8
A robust CETSA data analysis automation workflow for routine screening	8
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
Publisher's Note	8
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	7
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
SLAS Discovery – The Next Generation of Research	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	7
Creating a more strategic small molecule biophysical hit characterization workflow	7
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	7
Using chemical and biological data to predict drug toxicity	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	6
Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5–ATG16L1 Protein–Protein Interaction Inhibitors	6
Characterisation of high throughput screening outputs for small molecule degrader discovery	6

WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	6
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR	6
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	6
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	6
Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties	6
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	6
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	6