SLAS Discovery

Article	Citations
E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones	188
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery	123
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors	59
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2	44
Cryo-EM: The Resolution Revolution and Drug Discovery	39
Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery	37
High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids	37
High-Throughput Mass Spectrometry for Hit Identification: Current Landscape and Future Perspectives	35
Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery	34
Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3	32
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry	30
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	30
Identification of Compounds for Butyrylcholinesterase Inhibition	29
Using chemical and biological data to predict drug toxicity	29
Changing the HTS Paradigm: AI-Driven Iterative Screening for Hit Finding	28
Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries	28
CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle–Dependent Degradation of CDK2	27
Target Validation Using PROTACs: Applying the Four Pillars Framework	26
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	26
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	25
A Review of the Preclinical and Clinical Efficacy of Remdesivir, Hydroxychloroquine, and Lopinavir-Ritonavir Treatments against COVID-19	24
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19	24
Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data	22
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex	22
Validating ADME QSAR Models Using Marketed Drugs	22

A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts	22
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics	22
Small-Molecule Degraders beyond PROTACs—Challenges and Opportunities	21
Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development	21
Comparative Analysis of Multiple Immunoassays for Cytokine Profiling in Drug Discovery	21
Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19	20
Lead identification using 3D models of pancreatic cancer	19
ASCT1 and ASCT2: Brother and Sister?	19
A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry	18
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry	18
The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration	18
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors	18
Evaluating Very Deep Convolutional Neural Networks for Nucleus Segmentation from Brightfield Cell Microscopy Images	17
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	17
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput	17
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	16
Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns	16
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	16
waveRAPID—A Robust Assay for High-Throughput Kinetic Screens with the Creoptix WAVEsystem	15
A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids	15
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination	15
COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging Epidemics	15
The Vital Role of Proteomics in Characterizing Novel Protein Degraders	14
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target	13
Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1–Nrf2 Protein–Protein Interaction	13
A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities	12
Characterizations of the Urate Transporter, GLUT9, and Its Potent Inhibitors by Patch-Clamp Technique	12
Luminescence Energy Transfer–Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery	12
Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases	12
Optimization of a Colorimetric Assay to Determine Lactate Dehydrogenase B Activity Using Design of Experiments	12
Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance	11
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry	11
Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening	11
The Extensive and Expensive Impacts of HEp-2 [HeLa], Intestine 407 [HeLa], and Other False Cell Lines in Journal Publications	11
Automation of Organoid Cultures: Current Protocols and Applications	11
Evolution and impact of high content imaging	11
Operationalizing the Use of Biofabricated Tissue Models as Preclinical Screening Platforms for Drug Discovery and Development	11
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	11
deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids	11
Hit Discovery for Public Target Programs in the European Lead Factory: Experiences and Output from Assay Development and Ultra-High-Throughput Screening	10
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	10
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	10
Fragment-based screening: A new paradigm for ligand and target discovery	10
Saporin, a Polynucleotide–Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection	10
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	9
Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling	9
High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ	9
Mass spectrometry-based proteomics of 3D cell culture: A useful tool to validate culture of spheroids and organoids	9
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR	8
Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors	8

Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates	8
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	8
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease	8
A Solid Supported Membrane-Based Technology for Electrophysical Screening of B0AT1-Modulating Compounds	7
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1	7
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase rep	7
A perspective on the discovery of enzyme activators	7
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	7
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	7
Screening for modulators of autism spectrum disorder using induced human neurons	7
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells	7
Assay Guidance Manual for Drug Discovery: Robust or Go Bust	6
Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay	6
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	6
NMR Reporter Assays for the Quantification of Weak-Affinity Receptor–Ligand Interactions	6
A “Target Class” Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels	6
Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR	6
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes	6
Maintaining a High-Quality Screening Collection: The GSK Experience	6
High-throughput approaches to uncover synergistic drug combinations in leukemia	6
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	6
High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes	6
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	6
Treating Cells as Reagents to Design Reproducible Assays	6
The CellRaft AIRⓇ system: A novel system enabling organoid imaging, identification, and isolation	6
A New Method for Screening Natural Products to Stimulate IFN-γ Production in Jurkat Human T Lymphocytes	6
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	6
Automated high-content imaging in iPSC-derived neuronal progenitors	6
P-Glycoprotein-Mediated Efflux Using a Rapidly Maturing Caco2 Clone (CLEFF4) in Only 5 Days without Requiring Modified Growth Medium	6
Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5–ATG16L1 Protein–Protein Interaction Inhibitors	6
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	5
Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties	5
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons	5
Fast Mek1 Hit Identification with TRIC Technology Correlates Well with Other Biophysical Methods	5
Key aspects of modern GPCR drug discovery	5
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	5
In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors	5
Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity	5
Development of a Microscale Thermophoresis-Based Method for Screening and Characterizing Inhibitors of the Methyl-Lysine Reader Protein MRG15	5
Potential Repurposed Therapeutics and New Vaccines against COVID-19 and Their Clinical Status	5
Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery	5
A Novel High-Throughput FLIPR Tetra–Based Method for Capturing Highly Confluent Kinetic Data for Structure–Kinetic Relationship Guided Early Drug Discovery	5
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	4
Protocol for 3D screening of lung cancer spheroids using natural products	4
Development of a High-Throughput Assay to Identify Inhibitors of ENPP1	4
Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients	4
Identification of Two Non-Peptidergic Small Molecule Inhibitors of CBX2 Binding to K27 Trimethylated Oligonucleosomes	4
In-Plate Cryopreservation of 2D and 3D Cell Models: Innovative Tools for Biomedical Research and Preclinical Drug Discovery	4
Protocol for 3D drug sensitivity and resistance testing of patient-derived cancer cells in 384-well plates	4
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance	4
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	4
Characterization of Transport Activity of SLC11 Transporters in Xenopus laevis Oocytes by Fluorophore Quenching	4
Therapeutic approaches for Type 1 Diabetes: Promising cell-based approaches to achieve ultimate success	4
Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS)	4
Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT)	4
Utilising acoustic mist ionisation mass spectrometry to identify redox cycling compounds in high throughput screening outputs	4
High-throughput detection of metal contamination in HTS outputs	4
Validation of a High-Throughput Calcium Mobilization Assay for the Human Trace Amine-Associated Receptor 1	4
High-Throughput Mechanism of Inhibition	4
WITHDRAWN: In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	4
DeepTI: A deep learning-based framework decoding tumor-immune interactions for precision immunotherapy in oncology	4
High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes	4
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	4
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	3
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	3
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell–Derived Ventricular Cardiomyocytes Using Multielectrode Array	3
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	3
BRET measurement on CCD camera-based microtiter plate readers	3
Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging	3
A high-throughput screening assay for mutant isocitrate dehydrogenase 1 using acoustic droplet ejection mass spectrometry	3
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	3
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines	3
Therapeutic and Vaccine Options for COVID-19: Status after Six Months of the Disease Outbreak	3
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	3
Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors	3
Role Of Vaccines Against COVID-19 Pandemic	3
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	3
A Quantitative Bioassay to Determine the Inhibitory Potency of NGF–TrkA Antagonists	3
Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay	3
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	3

Development of a high-throughput assay to identify inhibitors of the ubiquitin-conjugating enzyme UBCH10	3
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	3
Developing recombinant antibodies by phage display technology to neutralize viral infectious diseases	3
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes	3
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	3
Quantitative Automated Assays in Living Cells to Screen for Inhibitors of Hemichannel Function	3
Covalent hits and where to find them	3
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	3
Optimization of a High-Throughput Cell-Based Screening Strategy to Identify Small-Molecule Inhibitors of IL-23 Signaling	3
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	3
In Vitro Pharmacokinetic/Pharmacodynamic Modeling of HIV Latency Reversal by Novel HDAC Inhibitors Using an Automated Platform	3
High throughput screening for compounds to the orphan nuclear receptor NR2F6	3
Leveraging Automation toward Development of a High-Throughput Gene Expression Profiling Platform	3
Identification and Kinetic Characterization of Serum- and Glucocorticoid-Regulated Kinase Inhibitors Using a Fluorescence Polarization–Based Assay	3