OOIR: Observatory of International Research

Papers

(The median citation count of SLAS Discovery is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	120
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	47
Bioassay protocol metadata annotation: Proposed standards adoption	44
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	41
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	40
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	34
Protocol for 3D screening of lung cancer spheroids using natural products	31
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	29
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	27
Outline and background for the EU-OS solubility prediction challenge	26
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	24
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	23
Emerging drug discovery ecosystems	22
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	22
Role Of Vaccines Against COVID-19 Pandemic	21
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	19
Drug repurposing screen for the rare disease ataxia-telangiectasia	18
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	17
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	16
An efficient and scalable data analysis solution for automated electrophysiology platforms	16
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	16
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	14
The Impact of Assay Design on Medicinal Chemistry: Case Studies	14
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	14
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	14

Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	13
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	13
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	12
Screening for molecular glues – Challenges and opportunities	12
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	12
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	12
In Memoriam	12
Screening for modulators of autism spectrum disorder using induced human neurons	11
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	11
Protocol to develop A 3D tumor model for drug testing applications	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
High-Throughput cell-based immunofluorescence assays against influenza	10
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	10
Development of a live cell assay for the zinc transporter ZnT8	10
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
A perspective on the discovery of enzyme activators	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	8
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	8
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	8
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	8
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	8
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	8
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	8
Publisher's Note	8
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	7
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
SLAS Discovery – The Next Generation of Research	7
A robust CETSA data analysis automation workflow for routine screening	7
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	7
Creating a more strategic small molecule biophysical hit characterization workflow	7
Using chemical and biological data to predict drug toxicity	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	6
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	6
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	6
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	6
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	6
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	6
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	6
A biochemical screening platform to target chromatin states using condensates as a tool	5
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	5
Protocols in drug discovery	5

Characterisation of high throughput screening outputs for small molecule degrader discovery	5
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	5
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	5
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	5
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	5
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	5
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	5
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	5
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	5
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	4
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	4
Antimicrobial resistance: Linking molecular mechanisms to public health impact	4
Thank You to Our 2021 Reviewers	4
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	4
High-throughput approaches to uncover synergistic drug combinations in leukemia	4
Drug discovery efforts at George Mason University	4
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	4
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	4
DeepTI: A deep learning-based framework decoding tumor-immune interactions for precision immunotherapy in oncology	4
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	4
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	4
The SLAS Discovery Editor's Top 10 for 2021	4
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	4
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	4
Addressing Unusual Assay Variability with Robust Statistics	4
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	4
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	4
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	4
Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency	4
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	4
Deep phenotyping of surface stimulatory and inhibitory co-receptors on cancer-resident T and NK cells reveals cell subsets within the tumor-reactive CTL population that are uniquely defined by NKG2A e	3
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	3
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	3
Lead identification using 3D models of pancreatic cancer	3
Graph neural networks for the identification of novel inhibitors of a small RNA	3
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	3
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	3
Advancing the development of TRIP13 inhibitors: A high-throughput screening approach	3
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay	3
Mathematical relationships between control group variability and assay quality metrics	3
Treating Cells as Reagents to Design Reproducible Assays	3
Orthogonal temperature-related intensity change (TRIC) and TR-FRET as a high-throughput screening platform for the discovery of SLIT2 binders: A proof-of-concept approach	3
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	3
Alternate dyes for image-based profiling assays	3
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	3
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	3
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	3
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	3
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	3
High throughput screening for compounds to the orphan nuclear receptor NR2F6	3
Fragment-based screening: A new paradigm for ligand and target discovery	3
Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators	3
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	3
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	3
A high throughput assay for phosphoribosylformylglycinamidine synthase	3
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	3
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	3
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	3
The role of m6A in lipid metabolism-related diseases	3
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies	2
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B	2
Magnetic three-dimensional bioprinting protocol for salivary gland mucoepidermoid carcinoma tumoroid culture	2
Structure-activity relationships of thiadiazole agonists of the human secretin receptor	2
A “Failed” Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage	2
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	2
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	2
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids	2
BRET measurement on CCD camera-based microtiter plate readers	2
MT1G activation in dopaminergic neurons identifies chelators and their relationships to cytotoxicity	2
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells	2
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	2
1st EU-OPENSCREEN/SLAS data mining competition to predict compounds solubility	2
WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	2
Toxicity evaluation of pharmaceutical drugs and quantum dots (QDs) using zebrafish embryos – A comprehensive review	2
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer	2
Development of a biotin–streptavidin-enhanced enzyme-linked immunosorbent assay (BA-ELISA) for high-throughput screening of KRASG12C inhibitors	2
High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle	2
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	2
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	2
ATPase activity profiling of three human DExD/H-box RNA helicases	2