SLAS Discovery

Article	Citations
Fast Mek1 Hit Identification with TRIC Technology Correlates Well with Other Biophysical Methods	223
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids	62
Magnetic three-dimensional bioprinting protocol for salivary gland mucoepidermoid carcinoma tumoroid culture	61
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer	42
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	40
A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications	39
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	36
Publisher's Note	30
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	29
High-throughput approaches to uncover synergistic drug combinations in leukemia	28
High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons	27
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	27
Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling	27
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	27
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	26
In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors	26
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	25
Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery	25
Approaches for Prioritizing High-Quality Chemical Matter in Chemical Probe and Drug Discovery	23
A Quantitative Bioassay to Determine the Inhibitory Potency of NGF–TrkA Antagonists	22
BRET measurement on CCD camera-based microtiter plate readers	22
Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues	22
A Novel High-Throughput FLIPR Tetra–Based Method for Capturing Highly Confluent Kinetic Data for Structure–Kinetic Relationship Guided Early Drug Discovery	22
A robust CETSA data analysis automation workflow for routine screening	21
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B	20

POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	19
Bioassay protocol metadata annotation: Proposed standards adoption	18
Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular and behavioral pharmacology and computatio	18
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	18
Reduced levels of serum EPA and DHA identified in patients with non-small-cell lung cancer using a new rapid validated LC-MS/MS method	17
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	17
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	17
Consideration of vendor-related differences in hepatic metabolic stability data to optimize early ADME screening in drug discovery	16
Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors	16
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	15
High throughput assay for compounds that boost BDNF expression in neurons	15
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	15
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies	15
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	14
Outline and background for the EU-OS solubility prediction challenge	13
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	12
WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	12
Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay	11
The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration	11
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	11
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	11
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	11
Creating a more strategic small molecule biophysical hit characterization workflow	11
Using chemical and biological data to predict drug toxicity	10
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	10
Protocol for 3D screening of lung cancer spheroids using natural products	10
Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity	9
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	9
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	9
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	9
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	8
The SLAS Discovery Editor's Top 10 for 2021	8
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	8
Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein	8
Development of a biotin–streptavidin-enhanced enzyme-linked immunosorbent assay (BA-ELISA) for high-throughput screening of KRASG12C inhibitors	8
Corrigendum to DNA methylation-induced ablation of miR-133a accelerates cancer aggressiveness in glioma through upregulating peroxisome proliferator-activated receptor γ [SLAS Discov. 2022 Sep 5;S2472	7
Covalent hits and where to find them	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Reducing False Positives through the Application of Fluorescence Lifetime Technology: A Comparative Study Using TYK2 Kinase as a Model System	7
High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries	7
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons	7
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19	7
SLAS Discovery – The Next Generation of Research	7
Automation of Organoid Cultures: Current Protocols and Applications	7
A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities	7
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease	7
Drug repurposing screen for the rare disease ataxia-telangiectasia	6
An efficient and scalable data analysis solution for automated electrophysiology platforms	6
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	6
A Tale of Two Tails: Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts	6

Advances in Protein Degradation	6
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	6
High-throughput detection of metal contamination in HTS outputs	6
Assay Guidance Manual for Drug Discovery: Robust or Go Bust	6
Maintaining a High-Quality Screening Collection: The GSK Experience	6
Emerging drug discovery ecosystems	6
Quantitative target engagement of RIPK1 in human whole blood via the cellular thermal shift assay for potential pre-clinical and clinical applications	6
Development of a Novel Label-Free and High-Throughput Arginase-1 Assay Using Self-Assembled Monolayer Desorption Ionization Mass Spectrometry	6
Role Of Vaccines Against COVID-19 Pandemic	6
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance	6
Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development	5
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	5
A novel thin plate spline methodology to model tissue surfaces and quantify tumor cell invasion in organ-on-chip models	5
The Impact of Assay Design on Medicinal Chemistry: Case Studies	5
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	5
Drug discovery efforts at George Mason University	5
The Vital Role of Proteomics in Characterizing Novel Protein Degraders	5
The CellRaft AIRⓇ system: A novel system enabling organoid imaging, identification, and isolation	5
Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28	5
Rapid-response RNA-fluorescence in situ hybridization (FISH) assay platform for coronavirus antiviral high-throughput screening	5
Development of a high-throughput screening platform to identify new therapeutic agents for Medulloblastoma Group 3	4
Graph neural networks for the identification of novel inhibitors of a small RNA	4
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase rep	4
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	4
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	4
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	4
DNA methylation-induced ablation of miR-133a accelerates cancer aggressiveness in glioma through upregulating peroxisome proliferator-activated receptor γ	4
A neuronal cell-based reporter system for monitoring the activity of HDAC2	4
Real-time thiol detection in iPSC-derived neuron cultures using SemKur-IM, a novel fluorescent dithio probe	4
Protocol for 3D drug sensitivity and resistance testing of patient-derived cancer cells in 384-well plates	4
Design of experiments for the automated development of a multicellular cardiac model for high-throughput screening	4
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	4
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	4
Discovery of DTX3L inhibitors through a homogeneous FRET-based assay that monitors formation and removal of poly-ubiquitin chains	4
Luminescence Energy Transfer–Based Screening and Target Engagement Approaches for Chemical Biology and Drug Discovery	4
Utilising acoustic mist ionisation mass spectrometry to identify redox cycling compounds in high throughput screening outputs	4
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors	3
Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties	3
Novel beta-glucocerebrosidase chaperone compounds identified from cell-based screening reduce pathologically accumulated glucosylsphingosine in iPS-derived neuronal cells	3
High-throughput mechanistic screening of non-equilibrium inhibitors by a fully automated data analysis pipeline in early drug-discovery	3
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	3
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes	3
Enhancing scaffold-free spheroid models: 3D cell bioprinting method for metastatic HSC3–Oral squamous carcinoma cell line	3
Target Validation Using PROTACs: Applying the Four Pillars Framework	3
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	3
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	3
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	3
Development of a Novel SNAP-Epitope Tag/Near-Infrared Imaging Assay to Quantify G Protein-Coupled Receptor Degradation in Human Cells	3
Live cell painting: New nontoxic dye to probe cell physiology in high content screening	3
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	3
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex	3
Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery	3
ASCT1 and ASCT2: Brother and Sister?	3
Varieties of interactions of anti-CD133 aptamers with cell cultures from patient glioblastoma	3
Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT)	3
Label-free LC-MS based assay to characterize small molecule compound binding to cells	3
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics	3
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	3
The Communication of Hit Quality Using Natural History Visualizations (NHVs)	3
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	3
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	3
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	3
Development of a sensitive high-throughput enzymatic assay capable of measuring sub-nanomolar inhibitors of SARS-CoV2 Mpro	3
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	2
A high-throughput response to the SARS-CoV-2 pandemic	2
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	2
A high throughput assay for phosphoribosylformylglycinamidine synthase	2
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems	2
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	2
Lead identification using 3D models of pancreatic cancer	2
Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5–ATG16L1 Protein–Protein Interaction Inhibitors	2
Super-resolution microscopy as a drug discovery tool	2
Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues	2
Aldehyde Dehydrogenase 2 (ALDH2): A novel sorafenib target in hepatocellular carcinoma unraveled by the proteome-wide cellular thermal shift assay	2
A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disea	2
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	2
Screening for molecular glues – Challenges and opportunities	2
Profiling cells with DELs: Small molecule fingerprinting of cell surfaces	2
Evaluating Very Deep Convolutional Neural Networks for Nucleus Segmentation from Brightfield Cell Microscopy Images	2
Rapid luminescence-based screening method for SARS- CoV-2 inhibitors discovery	2

Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	2
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	2
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	2
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR	2
Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors	2