SLAS Discovery

Article	Citations
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	73
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	64
In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors	46
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	42
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	40
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	37
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	35
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	33
A Quantitative Bioassay to Determine the Inhibitory Potency of NGF–TrkA Antagonists	29
Bioassay protocol metadata annotation: Proposed standards adoption	28
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	27
Protocol for 3D screening of lung cancer spheroids using natural products	26
Outline and background for the EU-OS solubility prediction challenge	26
An efficient and scalable data analysis solution for automated electrophysiology platforms	25
Emerging drug discovery ecosystems	25
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19	24
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	24
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	23
Automation of Organoid Cultures: Current Protocols and Applications	22
The Impact of Assay Design on Medicinal Chemistry: Case Studies	20
Drug repurposing screen for the rare disease ataxia-telangiectasia	20
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	19
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	19
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	19
Role Of Vaccines Against COVID-19 Pandemic	19

Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	18
Screening for molecular glues – Challenges and opportunities	17
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	17
A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities	17
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	16
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	16
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	15
In Memoriam	14
Development of a live cell assay for the zinc transporter ZnT8	13
A perspective on the discovery of enzyme activators	13
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	13
Protocol to develop A 3D tumor model for drug testing applications	13
Screening for modulators of autism spectrum disorder using induced human neurons	12
High-Throughput cell-based immunofluorescence assays against influenza	12
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	11
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes	11
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	11
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	11
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	11
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	10
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
Biochemical and Cellular Profile of NIK Inhibitors with Long Residence Times	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	8
A robust CETSA data analysis automation workflow for routine screening	8
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
Publisher's Note	8
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	7
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
SLAS Discovery – The Next Generation of Research	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	7
Creating a more strategic small molecule biophysical hit characterization workflow	7
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	7
Using chemical and biological data to predict drug toxicity	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	6
Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5–ATG16L1 Protein–Protein Interaction Inhibitors	6
Characterisation of high throughput screening outputs for small molecule degrader discovery	6

WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	6
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR	6
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	6
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	6
Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties	6
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	6
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	6
Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance	5
Thank You to Our 2021 Reviewers	5
DeepTI: A deep learning-based framework decoding tumor-immune interactions for precision immunotherapy in oncology	5
Protocols in drug discovery	5
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	5
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry	5
NMR Reporter Assays for the Quantification of Weak-Affinity Receptor–Ligand Interactions	5
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines	5
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	5
A Biochemical Screening Platform to Target Chromatin States Using Condensates as a Tool	5
Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex	5
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	5
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	5
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	4
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	4
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	4
Fast Mek1 Hit Identification with TRIC Technology Correlates Well with Other Biophysical Methods	4
High-throughput approaches to uncover synergistic drug combinations in leukemia	4
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	4
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	4
A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications	4
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	4
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	4
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	4
Addressing Unusual Assay Variability with Robust Statistics	4
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	4
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	4
Mathematical relationships between control group variability and assay quality metrics	3
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay	3
Fragment-based screening: A new paradigm for ligand and target discovery	3
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	3
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors	3
A high throughput assay for phosphoribosylformylglycinamidine synthase	3
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	3
The SLAS Discovery Editor's Top 10 for 2021	3
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	3
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	3
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	3
Treating Cells as Reagents to Design Reproducible Assays	3
Development of an Image-Based HCS-Compatible Method for Endothelial Barrier Function Assessment	3
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	3
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	3
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	3
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	3
Drug discovery efforts at George Mason University	3
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	3
Graph neural networks for the identification of novel inhibitors of a small RNA	3
Deep phenotyping of surface stimulatory and inhibitory co-receptors on cancer-resident T and NK cells reveals cell subsets within the tumor-reactive CTL population that are uniquely defined by NKG2A e	3
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	3
A “Failed” Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage	3
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	3
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	3
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	3
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	3
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	3
Lead identification using 3D models of pancreatic cancer	3
Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development	3
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	3
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	2
Magnetic three-dimensional bioprinting protocol for salivary gland mucoepidermoid carcinoma tumoroid culture	2
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B	2
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids	2
The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration	2
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	2
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells	2
Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns	2
BRET measurement on CCD camera-based microtiter plate readers	2
Development of a biotin–streptavidin-enhanced enzyme-linked immunosorbent assay (BA-ELISA) for high-throughput screening of KRASG12C inhibitors	2
ATPase activity profiling of three human DExD/H-box RNA helicases	2
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies	2
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	2

WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	2
High throughput screening for compounds to the orphan nuclear receptor NR2F6	2
Structure-activity relationships of thiadiazole agonists of the human secretin receptor	2
Assay Guidance Manual for Drug Discovery: Robust or Go Bust	2
High-throughput detection of metal contamination in HTS outputs	2
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer	2
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	2
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	2