OOIR: Observatory of International Research

Papers

(The median citation count of SLAS Discovery is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	163
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	62
Outline and background for the EU-OS solubility prediction challenge	53
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	49
Bioassay protocol metadata annotation: Proposed standards adoption	35
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	33
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	25
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	25
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	24
Protocol for 3D screening of lung cancer spheroids using natural products	23
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	18
Role Of Vaccines Against COVID-19 Pandemic	17
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	17
An efficient and scalable data analysis solution for automated electrophysiology platforms	17
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	16
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	16
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	16
Drug repurposing screen for the rare disease ataxia-telangiectasia	15
Emerging drug discovery ecosystems	14
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	14
Screening for molecular glues – Challenges and opportunities	14
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	14
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	14
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	13
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down	13

In Memoriam	12
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	12
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	12
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	12
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
High-Throughput cell-based immunofluorescence assays against influenza	11
Protocol to develop A 3D tumor model for drug testing applications	10
A perspective on the discovery of enzyme activators	10
Development of a live cell assay for the zinc transporter ZnT8	10
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	9
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Creating a more strategic small molecule biophysical hit characterization workflow	9
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	9
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	8
Using chemical and biological data to predict drug toxicity	8
Publisher's Note	8
A robust CETSA data analysis automation workflow for routine screening	8
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	7
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	7
Characterisation of high throughput screening outputs for small molecule degrader discovery	7
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	7
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Binder2030: a quantitative membrane proteome binding dataset enabling AI-driven drug discovery	7
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	7
Protocols in drug discovery	7
High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	7
High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms	6
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	6
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	6
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	6
A biochemical screening platform to target chromatin states using condensates as a tool	6

Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	6
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	6
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	6
Antimicrobial resistance: Linking molecular mechanisms to public health impact	6
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	5
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	5
High-throughput approaches to uncover synergistic drug combinations in leukemia	5
Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency	5
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	5
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	5
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	5
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	5
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	5
Alternate dyes for image-based profiling assays	4
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	4
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	4
Drug discovery efforts at George Mason University	4
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	4
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	4
Orthogonal temperature-related intensity change (TRIC) and TR-FRET as a high-throughput screening platform for the discovery of SLIT2 binders: A proof-of-concept approach	4
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	4
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	4
Graph neural networks for the identification of novel inhibitors of a small RNA	4
Validation, optimization, and quality assessment of a neuro-behavioral in vivo assay for phenotypic high-content evaluation of anesthetics	4
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	4
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	4
Development of a NanoBiT based high throughput screening assay for discovery of NOS1-NOS1AP interaction inhibitors	4
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	4
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	4
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	4
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	4
PCIM: Learning pixel attributions via pixel-wise channel isolation mixing in high content imaging	4
A high throughput assay for phosphoribosylformylglycinamidine synthase	4
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	4
Advancing the development of TRIP13 inhibitors: A high-throughput screening approach	4
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	4
Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators	4
Magnetic three-dimensional bioprinting protocol for salivary gland mucoepidermoid carcinoma tumoroid culture	3
ATPase activity profiling of three human DExD/H-box RNA helicases	3
High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle	3
1st EU-OPENSCREEN/SLAS data mining competition to predict compounds solubility	3
Identification of a small molecule CAPON binder using affinity selection-mass spectrometry screening	3
High throughput screening for compounds to the orphan nuclear receptor NR2F6	3
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	3
BRET measurement on CCD camera-based microtiter plate readers	3
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids	3
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies	3
WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	3
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B	3
Structure-activity relationships of thiadiazole agonists of the human secretin receptor	3
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells	3
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay	3
The role of m6A in lipid metabolism-related diseases	3
Streamlining cellular thermal shift assay for ultra-high throughput screening	3
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer	3
Toxicity evaluation of pharmaceutical drugs and quantum dots (QDs) using zebrafish embryos – A comprehensive review	3
Beyond fluorescence: A critical look at AI-powered brightfield analysis for T-cell killing assays	3
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	3
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	3
Mathematical relationships between control group variability and assay quality metrics	3
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	3
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	3
MT1G activation in dopaminergic neurons identifies chelators and their relationships to cytotoxicity	3