OOIR: Observatory of International Research

Papers

(The TQCC of Birth Defects Research is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
	131
Believing in science	34
Reply to Correspondence “Beyond Aggregate Risk: Drug‐ and Organ‐Specific Nuances in Counseling on Antidepressant Teratogenicity” (Tsai et al. 2025)	33
Maternal cigarette smoking and alcohol consumption and congenital diaphragmatic hernia	32
Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action	31
Issue Information	30
How Does Maternal Lipopolysaccharide Exposure Impact Prenatal Testicular Development in Rats, and Could α‐Tocopherol Provide a Protective Effect? A Histological, Immunohistochemical and Biochemical St	28
Prenatal Exposure to Methamphetamine and Its Association With Birth Outcomes: A Meta‐Analysis	26
A Case Report: Co‐Occurrence of TNRC6B Gene Variant and Xq28 Microdeletion Syndrome With Comprehensive Literature Review	24
Community‐Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environme	22
Domestic Use of Solvents and Pesticides and the Risk of Hypospadias in Offspring: A Case–Control Study From Brittany, France	20
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The 129S1 / SvImJ Mouse Strain Is Resistant to the Effects of Early Embryonic Alcohol and Other So	19
Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction	19
Human‐Centered Design of a Contextualized Service Delivery Model for Families of Infants With Major Congenital Anomalies in Kenya	18
Potential Risk Factors for Total Anomalous Pulmonary Venous Return: National Birth Defects Prevention Study, 1997–2011 and the Birth Defects Study to Evaluate Pregnancy Exposures, 2014–2021	17
Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo	17
In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series	16
Why Has Gastroschisis Increased Over Time and Why Is It More Common in Infants of Young Mothers?	16
Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case‐control study	16
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Emerging understanding of the effects of cannabis use during pregnancy	15
Absence of developmental and reproductive toxicity in rats, rabbits, and zebrafish embryos exposed to antimalarial drug cabamiquine	15
Developmental toxicity induced by brodifacoum in zebrafish (Danio rerio) early life stages	15

Otocephaly Diagnosed Prenatally: A Case Study of a Rare Congenital Defect	13
Antifungal medication use during early pregnancy and the risk of congenital heart defects in the National Birth Defects Prevention Study, 1997–2011	13
Transmission of behavioral and cognitive impairments across generations in rats subjected to prenatal valproic acid exposure	13
A narrative review of exercise dose during pregnancy	12
Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor	12
Developmental safety of nirmatrelvir in zebrafish (Danio rerio) embryos	12
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Outcome of children with multicystic dysplastic kidney: Does involved side matter?	11
Prevalence and Risk Factors of Postpartum Depression in Southeastern Iranian Women	11
Using a health observance event to raise awareness: An assessment of World Birth Defects Day	11
Assessing Environmental Risks Factors in Anorectal Malformations: Case Report and Literature Review	11
A comparison of infants' birth defects self‐reported by mothers with data provided by general practitioners: Data from the Dutch Pregnancy Drug Register	10
Issue Information	10
Publicly funded healthcare costs associated with orofacial clefts for children born in Alberta, Canada between 2002 and 2018	10
A case of Williams syndrome with Wolff–Parkinson–White syndrome	10
Prenatal diagnosis of SLC25A24 Fontaine progeroid syndrome: description of the fetal phenotype, genotype and detection of parental mosaicism	10
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Assessing the Readability, Credibility, and Accuracy of Online Vaccine Information for Pregnant and Lactating Individuals: A Cross‐Platform Analysis	10
Prevalence and Risk Factors of Pediatric Neurosurgical Congenital Anomalies at Mbeya Zonal Referral Hospital, Tanzania	10
Effects of Pre‐Conception Stress and Dracocephalum moldavica Extract on Sperm Parameters and Sex Hormones in Parents and Offspring	10
MotherToBaby and CDC: Partnering to Provide a Rapid and Personalized Response to COVID‐19 Vaccine Inquiries During Pregnancy and Lactation	9
Embryo‐fetal safety evaluation of ondansetron in rats	9
Birth outcomes following in utero co‐exposure to tobacco and marijuana	9
Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos	9
Issue Information	9
Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses	9
A new 90‐day drinking water study of sodium cyanide in rats to further evaluate National Toxicology Program findings and inform risk assessment	9
Juvenile toxicity study of PF‐07256472/recifercept, a recombinant human soluble fibroblast growth factor receptor 3, in 2–3‐month‐old cynomolgus monkeys	9
Prevalence of congenital anomalies in the Dutch Caribbean islands of Aruba, Bonaire, and Curaçao	9
Machine Learning‐Based Risk Prediction Models for Pregnancy‐Related Syndromes	9
Intake of Trans‐Fat Diet With Prenatal Bisphenol A Exposure Induce Global DNA Methylation in Rats Offspring	8
A Global Update on the Status of Prevention of Folic Acid‐Preventable Spina Bifida and Anencephaly in Year 2024	8
Ezh2‐dependent methylation in oral epithelia promotes secondary palatogenesis	8
Post‐mortem rapid aneuploidy testing for holoprosencephaly	8
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An assessment of the reliability of 52 enhanced preliminary embryofetal development studies to detect developmental toxicity	8
Birth defects surveillance: Working together to advance science	8
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Enhancing the Classification of Congenital Heart Defects for Outcome Association Studies in Birth Defects Registries	8
Chloroacetonitrile reduces rat prenatal bone length and induces oxidative stress, apoptosis, and DNA damage in rat fetal liver	8
Rodent anogenital distance recommendations	7
Racial and ethnic differences in infant survival for hydrocephaly—Texas, 1999–2017	7
Correction to “Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos”	7
Sex‐dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain‐gut axis in a VPA‐induced autistic‐like model of rats	7
Associations between maternal reports of periconceptional fever from miscellaneous causes and structural birth defects	7
Issue Information	7
Correction to “Comments on “Maternal–fetal safety evaluation of an aqueous extract of Casearia sylvestris [ AECS	7
World health assembly resolution for preventing micronutrient deficiencies and associated neural tube defects—A case study of global partnerships for a successful resolution adoption	7
Knowledge of periconceptional folic acid supplementation and associated factors among pregnant women attending antenatal care at public health facilities in Hawassa, South Ethiopia	7

Effect of Nigella sativa Consumption During Pregnancy on Fertility, Morphological and Behaviors of Mice Offspring	7
The outcome and complications of modern staged repair surgery in newborns with classic bladder exstrophy in different genders: A retrospective study	7
PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome	7
Paternal Valproate Treatment and Risk of Childhood Neurodevelopmental Disorders: Precautionary Regulatory Measures Are Insufficiently Substantiated	7
Population‐based surveillance for birth defects potentially related to Zika virus infection including 3‐year mortality and developmental outcomes, and Early Intervention Program service use—New York C	6
Sodium valproate exposure influences the expression of pparg in the zebrafish model	6
Life Course Considerations in Environmental Health: Developmental Neurotoxicity of Domoic Acid at Doses Below Acute Effect Levels in Adult Humans	6
Ascertainment of malformations in pregnancy registries: Lessons learned in the North American AED Pregnancy Registry	6
A global update on the status of prevention of folic acid‐preventable spina bifida and anencephaly in year 2020: 30‐Year anniversary of gaining knowledge about folic acid's prevention potential for ne	6
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Recommendation to change the peer review process	6
Multiple subtypes of coxsackievirus group B can cause congenital heart disease	6
Assessment of postnatal femur development in Wistar Han rats	6
Survival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study	6
A global update on the status of prevention of folic acid‐preventable spina bifida and anencephaly in year 2022	6
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Protective effect of Agaricus bisporus mushroom against maternal and fetal damage induced by lead administration during pregnancy in rats	6
Issue Information	6
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The Effect of Maternal Pertussis Vaccination on Neonatal Health Outcomes in the Dutch Pregnancy Drug Register	6
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Association Between Self‐Reported Infections and Seropositivity Among Pregnant Women With Gastroschisis: A Case Control Study, With Emphasis on Chlamydia trachomatis	5
Beyond Aggregate Risk: Drug‐ and Organ‐Specific Nuances in Counseling on Antidepressant Teratogenicity	5
Maternal exposure to heparin products and risk of birth defects in the National Birth Defects Prevention Study	5
Epigenetic regulation of craniofacial development and disease	5
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Mortality Through 2021 Among Persons Born With Spina Bifida in Metropolitan Atlanta, 1981–2018	5
Risk of birth defects by pregestational type 1 or type 2 diabetes: National Birth Defects Prevention Study, 1997–2011	5
Maternal Exposure to Tap Water Disinfection By‐Products and Risk of Selected Congenital Heart Defects	5
Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring	5
Investigation of Teratogenic Concerns in the Coronavirus Disease of 2019 Era	5
A case‐control study characterizing polydactyly risk factors in Bogotá and Cali, Colombia between 2002 and 2020	5
A Supra‐Numerary Limb Grafted Onto a Sacrococcygeal Mass in a Child With Spinal Dysraphism: Case Report, Dysmorphogenesis, and Management Review	5
Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature	5
Mycophenolate mofetil exposure on embryonic and fetal ear development in rats during pregnancy	5
Issue Information	5
Impact of TMPRSS6 Genetic Variants on Maternal Iron Status in Pregnancy: A Systematic Review	5
A Generalized Machine Learning Model for Identifying Congenital Heart Defects (CHDs) Using ICD Codes	5
Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring	5
Comparing Folic Acid Interventions and Arsenic Reduction Strategies for Neural Tube Defect Prevention in Bangladesh: A Systematic Review and Decision Analysis	5
Reproductive and neurobehavioral effects of maternal exposure to dinotefuran in the F₁‐generation mice	5
Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor	5
Homozygous LOXL2 variant in individuals affected by non‐syndromic occipital encephalocele	5
Prenatal alcohol exposure can be determined from baby teeth: Proof of concept	5
Issue Information	5
Maternal Separation Exhibits a Sex Dimorphism in Memory Impairments in Adolescent Rats: Acute Methylphenidate Administration as a Treatment	5
Issue Information	5
Blastocyst Cavity Expansion Promotes Cell Polarization During Early Development of Mouse Embryos	5
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Measurement of Androgen‐Sensitive Preweaning Developmental Landmarks in Rodents: Best Practices and Toxicological Significance	4
Gastroschisis prevalence patterns in 27 surveillance programs from 24 countries, International Clearinghouse for Birth Defects Surveillance and Research, 1980–2017	4
Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?	4
Maternal Age‐Related Gender Bias in Trisomy 21 and Trisomy 18	4
Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study	4
Analysis of incidence data in developmental toxicity studies: Statistical tests to account for litter effects in fetal defect data	4
Issue Information	4
Maternal diabetes as a teratogenic factor for congenital heart defects in infants of diabetic mothers	4
Temporal Trends of Infant Mortality Secondary to Congenital Heart Disease: National CDC Cohort Analysis (1999–2020)	4
Joint Position Statement from the Society for Birth Defects Research and Prevention, the Organization of Teratology Information Specialists, and the Developmental Neurotoxicology Society: A Call for I	4
Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides	4
Vitelline vascular remnant causing intestinal obstruction in a patient with TARP syndrome	4
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Pregnancy and infant outcomes by trimester of SARS‐CoV ‐2 infection in pregnancy– SET‐NET , 22 jur	4
Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl/6 fetal liver	4
Factors associated with Medicaid participation among infants born with birth defects in Texas, 2010–2014	4
Issue Information	4
Recurrent Constellations of Embryonic Malformations ( RCEM ): Teratogenicity Linked to Transient Hypoxia and Hormone Pregnancy Tests Agrees With	4
In‐utero cannabis exposure and long‐term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research	4
The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway	4
The timing, duration, and severity of nausea and vomiting of pregnancy and adverse birth outcomes among controls without birth defects in the National Birth Defects Prevention Study	4
Neighborhood social deprivation and healthcare utilization, disability, and comorbidities among young adults with congenital heart defects: Congenital heart survey to recognize outcomes, needs, and we	4
Climate and environmental changes exacerbate health disparities in pregnant people and their offspring. How can we protect women and their babies?	4
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study	4
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Subdivided Historical Data to Assess Replicability of the Rat Embryo‐Fetal Developmental Toxicity Study	4
Hypothesis: By‐products of vascular disruption carried in the CSF affect prenatal brain development	4
Issue Information	4
A multi‐program analysis of cleft lip with cleft palate prevalence and mortality using data from 22 International Clearinghouse for Birth Defects Surveillance and Research programs, 1974–2014	4
Hdac1 and Hdac2 positively regulate Notch1 gain‐of‐function pathogenic signaling in committed osteoblasts of male mice	4
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Issue Information	3
Probing the Biological Plausibility of Fluoride as an Endocrine Disruptor	3
Issue Information	3
Conjoined twins and conjoined triplets: At the heart of the matter	3
Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries	3
Early childhood outcomes of NICU graduates with cytomegalovirus infection in California	3
Bladder augmentation in exstrophy vesicae: Long‐term results of a single experienced center	3
A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health	3
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Issue Information	3
Risks of Birth Defects Following In Utero Exposures to Unregulated Brominated Haloacetic Acids	3
COVID‐19 Vaccination During Pregnancy and Birth Defects: Results From the CDC COVID‐19 Vaccine Pregnancy Registry, United States 2021–2022	3
Issue Information	3
Spontaneous Resolution of Molar Tissue in Complete Hydatidiform Mole With a Coexisting Fetus	3
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Prenatal epigenetic factors are predisposing for neurodevelopmental disorders—Considering placenta as a model	3
Natural history study of Pseudoachondroplasia: A focus on oral health	3
Folate and vitamin B₁₂ status and predicted neural tube defects risk among nonpregnant women of reproductive age from the Malawi National Micronutrient Survey, 2015–20	3
Issue Information	3
Prophylactic use of cardiac medications for delay of left ventricular dysfunction in Duchenne muscular dystrophy	3
The relationship between maternal periconceptional micronutrient supplementation and non‐syndromic cleft lip/palate in offspring	3
Investigating the association between vitamin D dietary intake during pregnancy and incidence of clubfoot in neonates	3
Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects	3
Genitourinary infection and gastroschisis: A systematic review and meta‐analysis	3
A Case of a Fetus With SETD5 Mutation: Prenatal Phenotype and Literature Review	3
Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population	3
Observed Prevalence of Congenital Situs Inversus in the United States Before and During the SARS‐CoV‐2 Pandemic, 2017–2022	3
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Describing characteristics of adults with and without congenital heart defects hospitalized with COVID‐19	3
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High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction	3
Risk factors and characteristics of the birth of patients with craniofacial microsomia, a case–control study	3
Issue Information	3
Issue Information	3
Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein–protein interaction netw	3
Issue Information	3
Additional evidence for the vascular disruption defect hypothesis in a novel case of brainstem disconnection syndrome	3
Issue Information	3
Implications of abortion legislation on birth defect surveillance	3
Teratogenic Effect of OROV Infection: An Analysis of Its Causality	3
Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA	3
Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997–2011	3