OOIR: Observatory of International Research

Papers

(The TQCC of Birth Defects Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Evaluation of p21 expression and related autism‐like behavior in Bisphenol‐A exposed offspring of Wistar albino rats	33
Issue Information	21
Carbon monoxide affects early cardiac development in an avian model	21
Mechanical dissection and culture of mouse cranial neural crest cells	19
COL1A1 regulates the apoptosis of embryonic stem cells by mediating the PITX1/TBX4 signaling	18
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Reproductive and neurobehavioral effects of dinotefuran in an F₁‐generation toxicity study in mice	16
Issue Information	16
Validation of ICD‐9‐CM codes for major genitourinary birth defects in Military Health System administrative data, 2006–2014	16
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Terminal transverse limb defects with “nubbins”	14
Issue Information	14
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Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action	13
Homozygous LOXL2 variant in individuals affected by non‐syndromic occipital encephalocele	12
Sunspot activity and birth defects among Texas births (1999–2016)	11
Concordance between alizarin red stained skeleton and micro‐CT skeleton evaluation methods: A case study in New Zealand White rabbits	10
Childhood Educational Outcomes of Infants Born With Esophageal Atresia With or Without Tracheoesophageal Fistula	10
Abnormal placental cord insertion, hypertensive disorders of pregnancy and birth length may be involved in development of hypospadias in male fetuses	9
Prevention and awareness of birth defects across the lifespan using examples from congenital heart defects and spina bifida	9
Genotype–phenotype spectrum and correlations in Xia‐Gibbs syndrome: Report of five novel cases and literature review	9
Issue Information	9
Patterns of multiple congenital anomalies in the National Birth Defect Prevention Study: Challenges and insights	9
Issue Information	9

Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature	8
The burden of disease for children born alive with Turner syndrome—A European cohort study	8
Issue Information	8
Exposure to alirocumab during the first trimester of pregnancy: A case report	8
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Effect of chlorpyrifos and its metabolites on skeletal system development of chick embryo	8
Issue Information	8
Maternal exposure to heparin products and risk of birth defects in the National Birth Defects Prevention Study	8
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Prevalence of craniosynostosis in Finland, 1987–2010: A population‐based study	7
Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction	7
School age educational outcomes of infants born with congenital diaphragmatic hernia	7
Comments on: “Evidence for a cluster of rare birth defects in the Ain Department (France)” (Gnansia et al., Birth Defects Research. 2021)	7
Investigation of a transient increase in omphalocele prevalence in a birth cohort of TRICARE beneficiaries	7
Maternotoxicity and fetotoxicity in Rattus norvegicus albinus exposed to tramadol during the late phase of pregnancy	7
HESI workshop summary: Interpretation of developmental and reproductive toxicity endpoints and the impact on data interpretation of adverse events	7
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Bengt Källén	7
AmicroRNAor messengerRNApoint of departure estimates an apical endpoint point of departure in a rat developmental toxicity model	7
Mycophenolate mofetil exposure on embryonic and fetal ear development in rats during pregnancy	7
Believing in science	6
Melatonin inhibits embryonic rat H9c2 cells growth through induction of apoptosis and cell cycle arrest via PI3K‐AKT signaling pathway	6
Dolutegravir and rat whole embryo culture	6
Comparison of Apgar scores and cord blood gas parameters in fetuses with isolated congenital heart disease and healthy controls	6
Relationship between achieving Sustainable Development Goals and promoting optimal care and prevention of birth defects globally	6
Animal evidence considered in determination of cannabis smoke and Δ⁹‐tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint); Part I. Somatic development	6
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Update on the impact of voluntary folic acid fortification of corn masa flour on red blood cell folate concentrations—National Health and Nutrition Examination Survey, 2011–March 2020	6
Epigenetic implications in maternal diabetes and metabolic syndrome‐associated risk of orofacial clefts	6
Issue Information	6
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Cardiovascular Ultrasound Predictors for Brain Alterations in Fetuses With Heart Disease: An Exploratory Review of the Literature	6
Issue Information	6
Issue Information	6
A novel human stem cell‐based biomarker assay for in vitro assessment of developmental toxicity	6
Beyond the heart: Cognitive and verbal outcomes in Arab children with congenital heart diseases	6
Reproductive and neurobehavioral effects of maternal exposure to dinotefuran in the F₁‐generation mice	6
Community‐Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environme	5
New classification of the penoscrotal positional anomalies	5
Periconceptional nonsteroidal anti‐inflammatory drug use, folic acid intake, and the risk of spina bifida	5
Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo	5
Prevalence of congenital anomalies according to maternal race and ethnicity, Texas, 1999–2018	5
Prenatal alcohol exposure can be determined from baby teeth: Proof of concept	5
Temporal Trends of Infant Mortality Secondary to Congenital Heart Disease: National CDC Cohort Analysis (1999–2020)	5
Real‐world prevalence, time of diagnosis, and co‐occurrence patterns of birth defects in live‐born infants, 2014–2020: A health administrative database study in Japan	5
Combined effects of maternal exposure to fungicides on behavioral development in F₁‐generation mice: 3. Fixed‐dose study of imazalil	5
Characteristics and first‐year mortality, by lesion level, among infants with spina bifida in the New York State Birth Defects Registry, 2008–2017	5

Partial atrioventricular canal defect and aortic coarctation associated with variants in GDF1 and NOTCH1 genes: A case report	5
Gastroschisis in Ontario, Canada: 2012–2018	5
Maternal cigarette smoking and alcohol consumption and congenital diaphragmatic hernia	5
A Comparison of Active and Passive Surveillance Strategies for Selected Birth Defects in New York	5
Parental Smoking and the Risk of Birth Defects in Offspring in China: A Systematic Review and meta‐Analysis	5
(−)‐Epicatechin gallate ameliorates cyprodinil‐induced cardiac developmental defects through inhibiting aryl hydrocarbon receptor in zebrafish	5
Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor	5
Maternal diabetes as a teratogenic factor for congenital heart defects in infants of diabetic mothers	5
Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter	5
A multi‐program analysis of cleft lip with cleft palate prevalence and mortality using data from 22 International Clearinghouse for Birth Defects Surveillance and Research programs, 1974–2014	5
The miR‐17‐92 cluster in cardiac health and disease	4
Resveratrol ameliorates toxic effects of cadmium on placental development in mouse placenta and human trophoblast cells	4
Exploring Ensemble Learning Techniques for Infant Mortality Prediction: A Technical Analysis of XGBoost Stacking AdaBoost and Bagging Models	4
Neighborhood location and nutritional resources as a risk factor for congenital heart disease in the fetus	4
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Perinatal Outcomes in Patients With Neural Tube Defects in a Middle‐Income Setting	4
Gastrulation‐stage alcohol exposure induces similar rates of craniofacial malformations in male and female C57BL/6J mice	4
Pre‐ and Postnatal Development Study of Nemolizumab, a Humanized Anti‐Interleukin‐31 Receptor A Monoclonal Antibody, in Cynomolgus Monkey	4
Epidemiology of Coloboma: Prevalence and Patterns in Texas, 1999–2014	4
Congenital cytomegalovirus surveillance in the United States	4
Review: Hormone Pregnancy Tests Were Teratogenic by the Same Failed Abortion and Hypoxia‐Related Mechanism as Misoprostol	4
A case‐control study characterizing polydactyly risk factors in Bogotá and Cali, Colombia between 2002 and 2020	4
Issue Information	4
Impact of perinatal exposure counseling on patient reported emotional outcomes and decisional empowerment	4
High glucose‐increased miR‐200c contributes to cellular senescence and DNA damage in neural stem cells	4
Epigenetic regulation of craniofacial development and disease	4
Educational Attainment and Employment Status of Adults Living With Congenital Heart Disease in the United States, CH STRONG 2016–2019	4
Association Between Self‐Reported Infections and Seropositivity Among Pregnant Women With Gastroschisis: A Case Control Study, With Emphasis on Chlamydia trachomatis	4
In‐utero cannabis exposure and long‐term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research	4
Stone Babies: A Pictorial Essay With Insights From 25 Museal Lithopaedions	4
Effect of tramadol hydrochloride on neural tube development in 48‐hr chick embryos: Argyrophilic nucleolar organizing region and genetic analysis study	4
Monochorionic triplet pregnancy complicated by conjoined twins and early twin–twin transfusion syndrome	4
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Why Has Gastroschisis Increased Over Time and Why Is It More Common in Infants of Young Mothers?	4
A Supra‐Numerary Limb Grafted Onto a Sacrococcygeal Mass in a Child With Spinal Dysraphism: Case Report, Dysmorphogenesis, and Management Review	4
Radiation risks and information needs of pregnant and lactating women	4
Issue Information	3
Bob Brent: Scientist, physician, scholar, teacher, mentor, and mensch	3
Issue Information	3
Transmission of behavioral and cognitive impairments across generations in rats subjected to prenatal valproic acid exposure	3
Neural tube defects: Prevalence, mortality, and maternal characteristics in two departmental hospitals in the northwestern region of Nicaragua, 2006–2018	3
Reviewer thank you 2022	3
Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder	3
Hepatotoxicity in young adult rat offspring after prenatal exposure to benzo(a)pyrene, and protective effect of atorvastatin	3
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Risk of birth defects in pregnant persons with sleep‐disordered breathing during pregnancy	3
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Using a health observance event to raise awareness: An assessment of World Birth Defects Day	3
Antifungal medication use during early pregnancy and the risk of congenital heart defects in the National Birth Defects Prevention Study, 1997–2011	3
Modification of the association between diabetes and birth defects by obesity, National Birth Defects Prevention Study, 1997–2011	3
Pharmacological Inhibition of the Spliceosome SF3b Complex by Pladienolide‐B Elicits Craniofacial Developmental Defects in Mouse and Zebrafish	3
Amelia and phocomelia in Finland: Characteristics and prevalences in a nationwide population‐based study	3
Otocephaly Diagnosed Prenatally: A Case Study of a Rare Congenital Defect	3
Issue Information	3
Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study	3
Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor	3
Climate and environmental changes exacerbate health disparities in pregnant people and their offspring. How can we protect women and their babies?	3
Craniorachipagus symmetric conjoined twinning: Identification of a fourth case and delineation of the phenotype	3
Parietal bone agenesis and athelia in retinoic acid embryopathy: An expansion of the phenotype	3
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A teratology information system in vernacular: Closing an information gap	3
Associations Between Maternal Periconceptional Alcohol Consumption and Risk of Craniosynostosis Among Offspring, National Birth Defects Prevention Study, 1997–2011	3
Retrospective analysis of neurological findings in esophageal atresia: Allostatic load of disease complexity, cumulative sedation, and anesthesia exposure	2
Hdac1 and Hdac2 positively regulate Notch1 gain‐of‐function pathogenic signaling in committed osteoblasts of male mice	2
Evaluation of gadolinium‐based contrast agents in pregnant CD‐1 mice and subsequent in utero exposure of the developing offspring, including behavioral evaluations	2
In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series	2
Elucidating arrhythmogenic right ventricular cardiomyopathy with stem cells	2
Lesion‐specific mortality due to congenital heart disease in U.S. adults from 1999 to 2017	2
Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case‐control study	2
Subdivided Historical Data to Assess Replicability of the Rat Embryo‐Fetal Developmental Toxicity Study	2
Issue Information	2
Developmental safety of nirmatrelvir in zebrafish (Danio rerio) embryos	2
Cannabidiol impairs neural tube closure in mouse whole embryo culture	2
Safety of prenatal opioid analgesics: Do results differ between public health insurance beneficiary and population‐based cohorts?	2
Maternal age and the prevalence of congenital heart defects in Europe, 1995–2015: A register‐based study	2
The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway	2
Analysis of incidence data in developmental toxicity studies: Statistical tests to account for litter effects in fetal defect data	2
Pregnancy and infant outcomes by trimester of SARS‐CoV‐2 infection in pregnancy–SET‐NET, 22 jurisdictions, January 25, 2020–December 31, 2020	2

Application of zebrafish in the study of craniomaxillofacial developmental anomalies	2
Hypothesis: By‐products of vascular disruption carried in the CSF affect prenatal brain development	2
Seasonal Fluctuation in the Incidence of Congenital Hypothyroidism Across Different Temperate Zones of China	2
Continued exposure to D‐galactose in postnatal period may inhibit excessive primordial follicle reduction in rats exposed prenatally to D‐galactose	2
Factors associated with Medicaid participation among infants born with birth defects in Texas, 2010–2014	2
Prevalence of Congenital Ocular Anomalies in 15 Countries of Europe: Results From the Medikeye Study	2
Children with Hirschsprung's disease have high morbidity in the first 5 years of life	2
Exome sequencing identifies novel genes underlying primary congenital glaucoma in the National Birth Defects Prevention Study	2
Prenatal diagnosis of fetuses with absent/hypoplastic nasal bone in second‐trimester using chromosomal microarray analysis	2
Maternal micronutrient deficiency and congenital heart disease risk: A systematic review of observational studies	2
Issue Information	2
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Developmental toxicity induced by brodifacoum in zebrafish (Danio rerio) early life stages	2
Developmental toxicity induced by triclosan exposure in zebrafish embryos	2
2021 U.S. Virgin Islands Zika health brigade: Providing recommended pediatric health screenings for children born to mothers with laboratory evidence of possible Zika virus infection during pregnancy	2
Post‐traumatic stress disorder, anxiety, and depression among adults with congenital heart defects	2
Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides	2
An example of parenchymal renal sparing in the context of complex malformations due to a novel mutation in the PBX1 gene	2
Identifying the landscape of developmental toxicity new approach methodologies	2
Terminal transverse limb defects	2
Vaccines in Pregnancy: An Update on Recommendations From CDC's Advisory Committee on Immunization Practices	2
Issue Information	2
Emerging understanding of the effects of cannabis use during pregnancy	2
Clinical profiling of pediatric microtia patients: A cross‐sectional analysis at a leading pediatric hospital in Ecuador (2015–2022)	2
Minimally invasive autopsy in the evaluation of fetal malformations and stillbirths: A feasibility study	2
Absence of developmental and reproductive toxicity in rats, rabbits, and zebrafish embryos exposed to antimalarial drug cabamiquine	2
Updated Joint Position Statement on Vaccines From the Society for Birth Defects Research and Prevention and the Organization of Teratology Information Specialists	2
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A machine learning model for predicting congenital heart defects from administrative data	2
Issue Information	2
Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl/6 fetal liver	2
Biological impacts of the green synthesized silver nanoparticles on the pregnant albino rats and their fetuses	2
Yolk sac development, function and role in rodent pregnancy	2
SETting up the genome: KMT2D and KDM6A genomic function in the Kabuki syndrome craniofacial developmental disorder	2
Survival of infants and children born with severe microcephaly, Texas, 1999–2015	2
Molecular insights of KMT2D and clinical aspects of Kabuki syndrome type 1	2
Baseline heart rate in infants with prenatal alcohol exposure: A systematic review and independent analysis	2
Fever and antibiotic use in maternal urinary tract infections during pregnancy and risk of congenital heart defects: Findings from the National Birth Defects Prevention Study	2
Cover Image	2