OOIR: Observatory of International Research

Papers

(The median citation count of Birth Defects Research is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Believing in science	64
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Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction	28
Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action	24
Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo	23
Dolutegravir and rat whole embryo culture	23
Maternal cigarette smoking and alcohol consumption and congenital diaphragmatic hernia	22
Community‐Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environme	21
Prenatal Exposure to Methamphetamine and Its Association With Birth Outcomes: A Meta‐Analysis	21
Reply to Correspondence “Beyond Aggregate Risk: Drug‐ and Organ‐Specific Nuances in Counseling on Antidepressant Teratogenicity” (Tsai et al. 2025)	21
How Does Maternal Lipopolysaccharide Exposure Impact Prenatal Testicular Development in Rats, and Could α‐Tocopherol Provide a Protective Effect? A Histological, Immunohistochemical and Biochemical St	19
Domestic Use of Solvents and Pesticides and the Risk of Hypospadias in Offspring: A Case–Control Study From Brittany, France	18
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Application of zebrafish in the study of craniomaxillofacial developmental anomalies	16
Evaluating the proportion of isolated cases among a spectrum of birth defects in a population‐based registry	16
A narrative review of exercise dose during pregnancy	14
Transmission of behavioral and cognitive impairments across generations in rats subjected to prenatal valproic acid exposure	14
Absence of developmental and reproductive toxicity in rats, rabbits, and zebrafish embryos exposed to antimalarial drug cabamiquine	14
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In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series	12
Developmental safety of nirmatrelvir in zebrafish (Danio rerio) embryos	12
Using a health observance event to raise awareness: An assessment of World Birth Defects Day	12
Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor	12
Cannabidiol impairs neural tube closure in mouse whole embryo culture	12

Developmental toxicity induced by brodifacoum in zebrafish (Danio rerio) early life stages	12
Otocephaly Diagnosed Prenatally: A Case Study of a Rare Congenital Defect	12
Emerging understanding of the effects of cannabis use during pregnancy	12
Antifungal medication use during early pregnancy and the risk of congenital heart defects in the National Birth Defects Prevention Study, 1997–2011	12
Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case‐control study	11
A comparison of infants' birth defects self‐reported by mothers with data provided by general practitioners: Data from the Dutch Pregnancy Drug Register	10
Identifying possible inaccuracy in reported birth head circumference measurements among infants in the US Zika Pregnancy and Infant Registry	10
Assessing the Readability, Credibility, and Accuracy of Online Vaccine Information for Pregnant and Lactating Individuals: A Cross‐Platform Analysis	10
Prevalence of critical congenital heart defects and selected co‐occurring congenital anomalies, 2014–2018: A U.S. population‐based study	10
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Prenatal diagnosis of SLC25A24 Fontaine progeroid syndrome: description of the fetal phenotype, genotype and detection of parental mosaicism	10
Outcome of children with multicystic dysplastic kidney: Does involved side matter?	10
A case of Williams syndrome with Wolff–Parkinson–White syndrome	10
Why Has Gastroschisis Increased Over Time and Why Is It More Common in Infants of Young Mothers?	10
Issue Information	10
Assessing Environmental Risks Factors in Anorectal Malformations: Case Report and Literature Review	10
Publicly funded healthcare costs associated with orofacial clefts for children born in Alberta, Canada between 2002 and 2018	9
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A new 90‐day drinking water study of sodium cyanide in rats to further evaluate National Toxicology Program findings and inform risk assessment	9
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Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses	9
Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition	9
Ezh2‐dependent methylation in oral epithelia promotes secondary palatogenesis	8
Juvenile toxicity study of PF‐07256472/recifercept, a recombinant human soluble fibroblast growth factor receptor 3, in 2–3‐month‐old cynomolgus monkeys	8
Issue Information	8
Enhancing the Classification of Congenital Heart Defects for Outcome Association Studies in Birth Defects Registries	8
MTHFR promoter methylation might mitigate the effect of smoking at the level of LINE‐1 in cleft lip tissues: A preliminary study	8
Translational potential of hiPSCs in predictive modeling of heart development and disease	8
An assessment of the reliability of 52 enhanced preliminary embryofetal development studies to detect developmental toxicity	8
Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos	8
MotherToBaby and CDC: Partnering to Provide a Rapid and Personalized Response to COVID‐19 Vaccine Inquiries During Pregnancy and Lactation	8
Use of vasoactive medications in pregnancy and the risk of stillbirth among birth defect cases	7
Chloroacetonitrile reduces rat prenatal bone length and induces oxidative stress, apoptosis, and DNA damage in rat fetal liver	7
Issue Information	7
Post‐mortem rapid aneuploidy testing for holoprosencephaly	7
World health assembly resolution for preventing micronutrient deficiencies and associated neural tube defects—A case study of global partnerships for a successful resolution adoption	7
Birth defects surveillance: Working together to advance science	7
Prevalence of congenital anomalies in the Dutch Caribbean islands of Aruba, Bonaire, and Curaçao	7
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Correction to “Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos”	7
Correction to “Comments on “Maternal–fetal safety evaluation of an aqueous extract of Casearia sylvestris [AECS] leaves in rats” (Nagaoka et al., 2023 [DOI: 10.1002/bdr2.2	7
Rodent anogenital distance recommendations	7
Intake of Trans‐Fat Diet With Prenatal Bisphenol A Exposure Induce Global DNA Methylation in Rats Offspring	7
Birth outcomes following in utero co‐exposure to tobacco and marijuana	7
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Embryo‐fetal safety evaluation of ondansetron in rats	7
Racial and ethnic differences in infant survival for hydrocephaly—Texas, 1999–2017	7
Paternal Valproate Treatment and Risk of Childhood Neurodevelopmental Disorders: Precautionary Regulatory Measures Are Insufficiently Substantiated	7
Hypothesized pathogenesis of acardius acephalus, acormus, amorphus, anceps, acardiac edema, single umbilical artery, and pump twin risk prediction	6
Knowledge of periconceptional folic acid supplementation and associated factors among pregnant women attending antenatal care at public health facilities in Hawassa, South Ethiopia	6

Survival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study	6
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A global update on the status of prevention of folic acid‐preventable spina bifida and anencephaly in year 2022	6
The outcome and complications of modern staged repair surgery in newborns with classic bladder exstrophy in different genders: A retrospective study	6
Associations between maternal reports of periconceptional fever from miscellaneous causes and structural birth defects	6
PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome	6
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Sex‐dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain‐gut axis in a VPA‐induced autistic‐like model of rats	6
Ascertainment of malformations in pregnancy registries: Lessons learned in the North American AED Pregnancy Registry	6
A global update on the status of prevention of folic acid‐preventable spina bifida and anencephaly in year 2020: 30‐Year anniversary of gaining knowledge about folic acid's prevention potential for ne	6
Protective effect of Agaricus bisporus mushroom against maternal and fetal damage induced by lead administration during pregnancy in rats	6
Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts—A meta‐analysis	6
Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring	5
Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature	5
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Risk of birth defects by pregestational type 1 or type 2 diabetes: National Birth Defects Prevention Study, 1997–2011	5
Population‐based surveillance for birth defects potentially related to Zika virus infection including 3‐year mortality and developmental outcomes, and Early Intervention Program service use—New York C	5
Comparative anatomy, pre‐ and postnatal changes during the development and maturation of the small intestine: Life‐stage influences on exposure	5
Issue Information	5
Sodium valproate exposure influences the expression of pparg in the zebrafish model	5
Issue Information	5
Mycophenolate mofetil exposure on embryonic and fetal ear development in rats during pregnancy	5
Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor	5
Issue Information	5
Maternal Separation Exhibits a Sex Dimorphism in Memory Impairments in Adolescent Rats: Acute Methylphenidate Administration as a Treatment	5
Issue Information	5
Assessment of postnatal femur development in Wistar Han rats	5
Life Course Considerations in Environmental Health: Developmental Neurotoxicity of Domoic Acid at Doses Below Acute Effect Levels in Adult Humans	5
Multiple subtypes of coxsackievirus group B can cause congenital heart disease	5
A multi‐program analysis of cleft lip with cleft palate prevalence and mortality using data from 22 International Clearinghouse for Birth Defects Surveillance and Research programs, 1974–2014	5
Maternal exposure to heparin products and risk of birth defects in the National Birth Defects Prevention Study	5
Homozygous LOXL2 variant in individuals affected by non‐syndromic occipital encephalocele	5
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A Generalized Machine Learning Model for Identifying Congenital Heart Defects (CHDs) Using ICD Codes	5
Recommendation to change the peer review process	5
Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring	5
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Reproductive and neurobehavioral effects of maternal exposure to dinotefuran in the F₁‐generation mice	5
Maternal Exposure to Tap Water Disinfection By‐Products and Risk of Selected Congenital Heart Defects	5
A case‐control study characterizing polydactyly risk factors in Bogotá and Cali, Colombia between 2002 and 2020	4
In‐utero cannabis exposure and long‐term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research	4
Subdivided Historical Data to Assess Replicability of the Rat Embryo‐Fetal Developmental Toxicity Study	4
Hypothesis: By‐products of vascular disruption carried in the CSF affect prenatal brain development	4
Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study	4
Maternal diabetes as a teratogenic factor for congenital heart defects in infants of diabetic mothers	4
Prenatal alcohol exposure can be determined from baby teeth: Proof of concept	4
Temporal Trends of Infant Mortality Secondary to Congenital Heart Disease: National CDC Cohort Analysis (1999–2020)	4
Comparing Folic Acid Interventions and Arsenic Reduction Strategies for Neural Tube Defect Prevention in Bangladesh: A Systematic Review and Decision Analysis	4
Issue Information	4
Analysis of incidence data in developmental toxicity studies: Statistical tests to account for litter effects in fetal defect data	4
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study	4
Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides	4
Blastocyst Cavity Expansion Promotes Cell Polarization During Early Development of Mouse Embryos	4
A Supra‐Numerary Limb Grafted Onto a Sacrococcygeal Mass in a Child With Spinal Dysraphism: Case Report, Dysmorphogenesis, and Management Review	4
Association Between Self‐Reported Infections and Seropositivity Among Pregnant Women With Gastroschisis: A Case Control Study, With Emphasis on Chlamydia trachomatis	4
Issue Information	4
Issue Information	4
Factors associated with Medicaid participation among infants born with birth defects in Texas, 2010–2014	4
Pregnancy and infant outcomes by trimester of SARS‐CoV‐2 infection in pregnancy–SET‐NET, 22 jurisdictions, January 25, 2020–December 31, 2020	4
Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl/6 fetal liver	4
Beyond Aggregate Risk: Drug‐ and Organ‐Specific Nuances in Counseling on Antidepressant Teratogenicity	4
Epigenetic regulation of craniofacial development and disease	4
Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues	3
Alobar holoprosencephaly in mining‐related areas of the Eastern region of the Democratic Republic of the Congo: A case series	3
Describing characteristics of adults with and without congenital heart defects hospitalized with COVID‐19	3
Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein–protein interaction netw	3
Additional evidence for the vascular disruption defect hypothesis in a novel case of brainstem disconnection syndrome	3
Issue Information	3
Regulation of Oct4 in stem cells and neural crest cells	3
Gastroschisis prevalence patterns in 27 surveillance programs from 24 countries, International Clearinghouse for Birth Defects Surveillance and Research, 1980–2017	3
Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997–2011	3
Prevalence of neural tube defects, maternal HIV status, and antiretroviral therapy from a hospital‐based birth defect surveillance in Kampala, Uganda	3
Observed Prevalence of Congenital Situs Inversus in the United States Before and During the SARS‐CoV‐2 Pandemic, 2017–2022	3
Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?	3
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Vitelline vascular remnant causing intestinal obstruction in a patient with TARP syndrome	3
Climate and environmental changes exacerbate health disparities in pregnant people and their offspring. How can we protect women and their babies?	3
Issue Information	3
High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction	3
Co‐occurrence of congenital anomalies by maternal race/ethnicity among infants and fetuses with Down syndrome, 2013–2017: A U.S. population‐based analysis	3

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Issue Information	3
Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries	3
The timing, duration, and severity of nausea and vomiting of pregnancy and adverse birth outcomes among controls without birth defects in the National Birth Defects Prevention Study	3
Investigating the association between vitamin D dietary intake during pregnancy and incidence of clubfoot in neonates	3
Daphne Trasler: In memoriam	3
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Early childhood outcomes of NICU graduates with cytomegalovirus infection in California	3
Maternal Age‐Related Gender Bias in Trisomy 21 and Trisomy 18	3
Measurement of Androgen‐Sensitive Preweaning Developmental Landmarks in Rodents: Best Practices and Toxicological Significance	3
Issue Information	3
Neighborhood social deprivation and healthcare utilization, disability, and comorbidities among young adults with congenital heart defects: Congenital heart survey to recognize outcomes, needs, and we	3
Implications of abortion legislation on birth defect surveillance	3
Maternal hereditary hemolytic anemia and birth defects in the National Birth Defects Prevention Study	3
Issue Information	3
Bladder augmentation in exstrophy vesicae: Long‐term results of a single experienced center	3
Prophylactic use of cardiac medications for delay of left ventricular dysfunction in Duchenne muscular dystrophy	3
Issue Information	3
A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health	3
Issue Information	3
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Natural history study of Pseudoachondroplasia: A focus on oral health	3
Hdac1 and Hdac2 positively regulate Notch1 gain‐of‐function pathogenic signaling in committed osteoblasts of male mice	3
Issue Information	3
The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway	3
Maternal immunization with Group B Streptococcus six‐valent polysaccharide conjugate vaccine supported by lack of toxicity in rat and rabbit fertility and developmental toxicity stud	2
Impact of perinatal exposure counseling on patient reported emotional outcomes and decisional empowerment	2
Issue Information	2
Fever and antibiotic use in maternal urinary tract infections during pregnancy and risk of congenital heart defects: Findings from the National Birth Defects Prevention Study	2
COVID‐19 Vaccination During Pregnancy and Birth Defects: Results From the CDC COVID‐19 Vaccine Pregnancy Registry, United States 2021–2022	2
Evaluation of gadolinium‐based contrast agents in pregnant CD‐1 mice and subsequent in utero exposure of the developing offspring, including behavioral evaluations	2
Mechanical dissection and culture of mouse cranial neural crest cells	2
A machine learning model for predicting congenital heart defects from administrative data	2
Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation	2
An example of parenchymal renal sparing in the context of complex malformations due to a novel mutation in the PBX1 gene	2
Toward better assessments of developmental toxicity using stem cell‐based in vitro embryogenesis models	2
Issue Information	2
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HESI workshop summary: Interpretation of developmental and reproductive toxicity endpoints and the impact on data interpretation of adverse events	2
Prenatal epigenetic factors are predisposing for neurodevelopmental disorders—Considering placenta as a model	2
New classification of the penoscrotal positional anomalies	2
Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter	2
Genitourinary infection and gastroschisis: A systematic review and meta‐analysis	2
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Reproductive and neurobehavioral effects of dinotefuran in an F₁‐generation toxicity study in mice	2
Parietal bone agenesis and athelia in retinoic acid embryopathy: An expansion of the phenotype	2
Folate and vitamin B₁₂ status and predicted neural tube defects risk among nonpregnant women of reproductive age from the Malawi National Micronutrient Survey, 2015–20	2
Retrospective analysis of neurological findings in esophageal atresia: Allostatic load of disease complexity, cumulative sedation, and anesthesia exposure	2
Society for Birth Defects Research and Prevention Symposium: Health Disparities Within Communities of Color	2
Prevention and awareness of birth defects across the lifespan using examples from congenital heart defects and spina bifida	2
Integration and application of new approach methodologies in assessing the developmental hazards: Case study with an antimalarial drug	2
2021 U.S. Virgin Islands Zika health brigade: Providing recommended pediatric health screenings for children born to mothers with laboratory evidence of possible Zika virus infection during pregnancy	2
Cardiovascular function during early development is suppressed by cinnamon flavored, nicotine‐free, electronic cigarette vapor	2
Effect of tramadol hydrochloride on neural tube development in 48‐hr chick embryos: Argyrophilic nucleolar organizing region and genetic analysis study	2
Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA	2
High‐throughput detection of craniofacial defects in fluorescent zebrafish	2
Issue Information	2
High glucose‐increased miR‐200c contributes to cellular senescence and DNA damage in neural stem cells	2
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Review: Hormone Pregnancy Tests Were Teratogenic by the Same Failed Abortion and Hypoxia‐Related Mechanism as Misoprostol	2
COL1A1 regulates the apoptosis of embryonic stem cells by mediating the PITX1/TBX4 signaling	2
Risk factors and characteristics of the birth of patients with craniofacial microsomia, a case–control study	2
Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split‐Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study	2
Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects	2
Real‐world prevalence, time of diagnosis, and co‐occurrence patterns of birth defects in live‐born infants, 2014–2020: A health administrative database study in Japan	2
From the Editor‐in‐Chief: Birth Defects Research 2023	2
BDR Reviewer Thank You	2
Correction to Food Fortification Ineffective in Preventing Neural Tube Defects in India due to Regulation Promoting Inadequate Levels of Folic Acid and Vitamin B12	2
Issue Information	2
Risk of birth defects in pregnant persons with sleep‐disordered breathing during pregnancy	2
Functional Evaluation of Neural Tube Defect‐Related Missense Mutations Using In Silico Methods	2
Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory	2
Issue Information	2
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Animal evidence considered in determination of cannabis smoke and Δ⁹‐tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint); Part I. Somatic development	2
Survival of infants and children born with severe microcephaly, Texas, 1999–2015	2
The relationship between maternal periconceptional micronutrient supplementation and non‐syndromic cleft lip/palate in offspring	2
Issue Information	2
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Prevalence of Congenital Ocular Anomalies in 15 Countries of Europe: Results From the Medikeye Study	2
Conjoined twins and conjoined triplets: At the heart of the matter	2
Childhood Educational Outcomes of Infants Born With Esophageal Atresia With or Without Tracheoesophageal Fistula	2
The miR‐17‐92 cluster in cardiac health and disease	2
Cover Image	2
Elucidating arrhythmogenic right ventricular cardiomyopathy with stem cells	2
Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population	2
Combined effects of maternal exposure to fungicides on behavioral development in F₁‐generation mice: 3. Fixed‐dose study of imazalil	2
A search for factors associated with reduced carbohydrate intake and NTD risk in two population‐based studies	1
A critical look at adjusted fetal weights in rats	1
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Construction and analysis of a joint diagnostic model of machine learning for cryptorchidism based on single‐cell sequencing	1
Teratogenic Effects of Serotonin Receptor 2B Disruption on the Migration and Cardiac Derivatives of the Cardiac Neural Crest	1
Expanding the Massachusetts Birth Defects Monitoring Program to include additional pregnancy outcomes: Programmatic efforts and impacts on case ascertainment, 2012–2020	1
Higher Incidence of Common Polymorphisms in the Genes of Folate and Methionine Cycles in Children With Orofacial Clefs and Congenital Heart Defects Compared to their Unaffected Siblings	1
Six‐month survival of a monochorionic monoamniotic twin with sirenomelia	1