OOIR: Observatory of International Research

Papers

(The median citation count of Birth Defects Research is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
	124
Believing in science	33
Protective Role of Vitamin B6 Against Teratogenic Effects Induced by Lead in Chick Embryo	32
A Case Report: Co‐Occurrence of TNRC6B Gene Variant and Xq28 Microdeletion Syndrome With Comprehensive Literature Review	31
Reply to Correspondence “Beyond Aggregate Risk: Drug‐ and Organ‐Specific Nuances in Counseling on Antidepressant Teratogenicity” (Tsai et al. 2025)	30
Maternal cigarette smoking and alcohol consumption and congenital diaphragmatic hernia	29
How Does Maternal Lipopolysaccharide Exposure Impact Prenatal Testicular Development in Rats, and Could α‐Tocopherol Provide a Protective Effect? A Histological, Immunohistochemical and Biochemical St	27
Prenatal Exposure to Methamphetamine and Its Association With Birth Outcomes: A Meta‐Analysis	25
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Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action	24
Domestic Use of Solvents and Pesticides and the Risk of Hypospadias in Offspring: A Case–Control Study From Brittany, France	22
Community‐Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environme	20
Issue Information	20
The 129S1 / SvImJ Mouse Strain Is Resistant to the Effects of Early Embryonic Alcohol and Other So	19
Human‐Centered Design of a Contextualized Service Delivery Model for Families of Infants With Major Congenital Anomalies in Kenya	18
Developmental exposure to the flame retardant, triphenyl phosphate, causes long‐lasting neurobehavioral and neurochemical dysfunction	18
In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series	17
Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor	16
Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case‐control study	15
Why Has Gastroschisis Increased Over Time and Why Is It More Common in Infants of Young Mothers?	15
Prevalence and Risk Factors of Postpartum Depression in Southeastern Iranian Women	15
Emerging understanding of the effects of cannabis use during pregnancy	15
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Developmental safety of nirmatrelvir in zebrafish (Danio rerio) embryos	14

Using a health observance event to raise awareness: An assessment of World Birth Defects Day	13
Developmental toxicity induced by brodifacoum in zebrafish (Danio rerio) early life stages	13
A narrative review of exercise dose during pregnancy	13
Otocephaly Diagnosed Prenatally: A Case Study of a Rare Congenital Defect	12
Absence of developmental and reproductive toxicity in rats, rabbits, and zebrafish embryos exposed to antimalarial drug cabamiquine	12
Antifungal medication use during early pregnancy and the risk of congenital heart defects in the National Birth Defects Prevention Study, 1997–2011	12
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Transmission of behavioral and cognitive impairments across generations in rats subjected to prenatal valproic acid exposure	11
Prevalence and Risk Factors of Pediatric Neurosurgical Congenital Anomalies at Mbeya Zonal Referral Hospital, Tanzania	10
A comparison of infants' birth defects self‐reported by mothers with data provided by general practitioners: Data from the Dutch Pregnancy Drug Register	10
Assessing Environmental Risks Factors in Anorectal Malformations: Case Report and Literature Review	10
Issue Information	10
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Outcome of children with multicystic dysplastic kidney: Does involved side matter?	10
A case of Williams syndrome with Wolff–Parkinson–White syndrome	10
Prenatal diagnosis of SLC25A24 Fontaine progeroid syndrome: description of the fetal phenotype, genotype and detection of parental mosaicism	10
Assessing the Readability, Credibility, and Accuracy of Online Vaccine Information for Pregnant and Lactating Individuals: A Cross‐Platform Analysis	10
Publicly funded healthcare costs associated with orofacial clefts for children born in Alberta, Canada between 2002 and 2018	9
Juvenile toxicity study of PF‐07256472/recifercept, a recombinant human soluble fibroblast growth factor receptor 3, in 2–3‐month‐old cynomolgus monkeys	9
Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses	9
A new 90‐day drinking water study of sodium cyanide in rats to further evaluate National Toxicology Program findings and inform risk assessment	9
MotherToBaby and CDC: Partnering to Provide a Rapid and Personalized Response to COVID‐19 Vaccine Inquiries During Pregnancy and Lactation	9
Embryo‐fetal safety evaluation of ondansetron in rats	9
Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos	9
Prevalence of congenital anomalies in the Dutch Caribbean islands of Aruba, Bonaire, and Curaçao	9
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Issue Information	9
An assessment of the reliability of 52 enhanced preliminary embryofetal development studies to detect developmental toxicity	9
Effects of Pre‐Conception Stress and Dracocephalum moldavica Extract on Sperm Parameters and Sex Hormones in Parents and Offspring	9
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Machine Learning‐Based Risk Prediction Models for Pregnancy‐Related Syndromes	8
Intake of Trans‐Fat Diet With Prenatal Bisphenol A Exposure Induce Global DNA Methylation in Rats Offspring	8
Ezh2‐dependent methylation in oral epithelia promotes secondary palatogenesis	8
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Chloroacetonitrile reduces rat prenatal bone length and induces oxidative stress, apoptosis, and DNA damage in rat fetal liver	8
Birth outcomes following in utero co‐exposure to tobacco and marijuana	8
Enhancing the Classification of Congenital Heart Defects for Outcome Association Studies in Birth Defects Registries	8
Birth defects surveillance: Working together to advance science	8
Correction to “Comments on “Maternal–fetal safety evaluation of an aqueous extract of Casearia sylvestris [ AECS	7
A global update on the status of prevention of folic acid‐preventable spina bifida and anencephaly in year 2022	7
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World health assembly resolution for preventing micronutrient deficiencies and associated neural tube defects—A case study of global partnerships for a successful resolution adoption	7
Effect of Nigella sativa Consumption During Pregnancy on Fertility, Morphological and Behaviors of Mice Offspring	7
PTBP3 Associated With 9q32 Locus Is a Candidate Gene for Nager Syndrome	7
Associations between maternal reports of periconceptional fever from miscellaneous causes and structural birth defects	7
Sex‐dependent alterations of inflammatory factors, oxidative stress, and histopathology of the brain‐gut axis in a VPA‐induced autistic‐like model of rats	7
The outcome and complications of modern staged repair surgery in newborns with classic bladder exstrophy in different genders: A retrospective study	7
Racial and ethnic differences in infant survival for hydrocephaly—Texas, 1999–2017	7
Correction to “Determination and analysis of sex ratios in heme oxygenase 1 gene targeted mouse embryos”	7
Ascertainment of malformations in pregnancy registries: Lessons learned in the North American AED Pregnancy Registry	7

A global update on the status of prevention of folic acid‐preventable spina bifida and anencephaly in year 2020: 30‐Year anniversary of gaining knowledge about folic acid's prevention potential for ne	7
Rodent anogenital distance recommendations	7
Issue Information	7
Post‐mortem rapid aneuploidy testing for holoprosencephaly	7
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Impact of TMPRSS6 Genetic Variants on Maternal Iron Status in Pregnancy: A Systematic Review	6
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The Effect of Maternal Pertussis Vaccination on Neonatal Health Outcomes in the Dutch Pregnancy Drug Register	6
Population‐based surveillance for birth defects potentially related to Zika virus infection including 3‐year mortality and developmental outcomes, and Early Intervention Program service use—New York C	6
Sodium valproate exposure influences the expression of pparg in the zebrafish model	6
Issue Information	6
Knowledge of periconceptional folic acid supplementation and associated factors among pregnant women attending antenatal care at public health facilities in Hawassa, South Ethiopia	6
Paternal Valproate Treatment and Risk of Childhood Neurodevelopmental Disorders: Precautionary Regulatory Measures Are Insufficiently Substantiated	6
Recommendation to change the peer review process	6
Multiple subtypes of coxsackievirus group B can cause congenital heart disease	6
Issue Information	6
Survival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study	6
Risk of birth defects by pregestational type 1 or type 2 diabetes: National Birth Defects Prevention Study, 1997–2011	5
Protective effect of Agaricus bisporus mushroom against maternal and fetal damage induced by lead administration during pregnancy in rats	5
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Maternal diabetes as a teratogenic factor for congenital heart defects in infants of diabetic mothers	5
A case‐control study characterizing polydactyly risk factors in Bogotá and Cali, Colombia between 2002 and 2020	5
Association Between Self‐Reported Infections and Seropositivity Among Pregnant Women With Gastroschisis: A Case Control Study, With Emphasis on Chlamydia trachomatis	5
Maternal exposure to heparin products and risk of birth defects in the National Birth Defects Prevention Study	5
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Mortality Through 2021 Among Persons Born With Spina Bifida in Metropolitan Atlanta, 1981–2018	5
Assessment of postnatal femur development in Wistar Han rats	5
Maternal Separation Exhibits a Sex Dimorphism in Memory Impairments in Adolescent Rats: Acute Methylphenidate Administration as a Treatment	5
Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring	5
Reproductive and neurobehavioral effects of maternal exposure to dinotefuran in the F₁‐generation mice	5
In‐utero cannabis exposure and long‐term psychiatric and neurodevelopmental outcomes: The limitations of existing literature and recommendations for future research	5
Homozygous LOXL2 variant in individuals affected by non‐syndromic occipital encephalocele	5
A Supra‐Numerary Limb Grafted Onto a Sacrococcygeal Mass in a Child With Spinal Dysraphism: Case Report, Dysmorphogenesis, and Management Review	5
Revisiting the testicular toxicity of cyanide: Assessment of the new and existing literature	5
Issue Information	5
Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring	5
Life Course Considerations in Environmental Health: Developmental Neurotoxicity of Domoic Acid at Doses Below Acute Effect Levels in Adult Humans	5
Maternal Exposure to Tap Water Disinfection By‐Products and Risk of Selected Congenital Heart Defects	5
Blastocyst Cavity Expansion Promotes Cell Polarization During Early Development of Mouse Embryos	5
Comparing Folic Acid Interventions and Arsenic Reduction Strategies for Neural Tube Defect Prevention in Bangladesh: A Systematic Review and Decision Analysis	5
Temporal Trends of Infant Mortality Secondary to Congenital Heart Disease: National CDC Cohort Analysis (1999–2020)	5
Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor	5
Mycophenolate mofetil exposure on embryonic and fetal ear development in rats during pregnancy	5
Beyond Aggregate Risk: Drug‐ and Organ‐Specific Nuances in Counseling on Antidepressant Teratogenicity	5
A Generalized Machine Learning Model for Identifying Congenital Heart Defects (CHDs) Using ICD Codes	5
Factors associated with Medicaid participation among infants born with birth defects in Texas, 2010–2014	4
Issue Information	4
Recurrent Constellations of Embryonic Malformations ( RCEM ): Teratogenicity Linked to Transient Hypoxia and Hormone Pregnancy Tests Agrees With	4
Hdac1 and Hdac2 positively regulate Notch1 gain‐of‐function pathogenic signaling in committed osteoblasts of male mice	4
Vitelline vascular remnant causing intestinal obstruction in a patient with TARP syndrome	4
Early childhood outcomes of NICU graduates with cytomegalovirus infection in California	4
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The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study	4
Pregnancy and infant outcomes by trimester of SARS‐CoV ‐2 infection in pregnancy– SET‐NET , 22 jur	4
Subdivided Historical Data to Assess Replicability of the Rat Embryo‐Fetal Developmental Toxicity Study	4
Hypothesis: By‐products of vascular disruption carried in the CSF affect prenatal brain development	4
A multi‐program analysis of cleft lip with cleft palate prevalence and mortality using data from 22 International Clearinghouse for Birth Defects Surveillance and Research programs, 1974–2014	4
Investigation of Teratogenic Concerns in the Coronavirus Disease of 2019 Era	4
Joint Position Statement from the Society for Birth Defects Research and Prevention, the Organization of Teratology Information Specialists, and the Developmental Neurotoxicology Society: A Call for I	4
Review of the state of science and evaluation of currently available in silico prediction models for reproductive and developmental toxicity: A case study on pesticides	4
Neighborhood social deprivation and healthcare utilization, disability, and comorbidities among young adults with congenital heart defects: Congenital heart survey to recognize outcomes, needs, and we	4
Measurement of Androgen‐Sensitive Preweaning Developmental Landmarks in Rodents: Best Practices and Toxicological Significance	4
Maternal Age‐Related Gender Bias in Trisomy 21 and Trisomy 18	4
Gestational exposure to triphenyl phosphate induces epigenetic modifications in C57Bl/6 fetal liver	4
Analysis of incidence data in developmental toxicity studies: Statistical tests to account for litter effects in fetal defect data	4
Issue Information	4
Epigenetic regulation of craniofacial development and disease	4
Prenatal alcohol exposure can be determined from baby teeth: Proof of concept	4
The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway	4
Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?	4
Gastroschisis prevalence patterns in 27 surveillance programs from 24 countries, International Clearinghouse for Birth Defects Surveillance and Research, 1980–2017	4
Climate and environmental changes exacerbate health disparities in pregnant people and their offspring. How can we protect women and their babies?	4
Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study	4
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Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues	3
Additional evidence for the vascular disruption defect hypothesis in a novel case of brainstem disconnection syndrome	3

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From the Editor‐in‐Chief: Birth Defects Research 2023	3
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Spontaneous Resolution of Molar Tissue in Complete Hydatidiform Mole With a Coexisting Fetus	3
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Implications of abortion legislation on birth defect surveillance	3
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Risks of Birth Defects Following In Utero Exposures to Unregulated Brominated Haloacetic Acids	3
Prenatal epigenetic factors are predisposing for neurodevelopmental disorders—Considering placenta as a model	3
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A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health	3
Conjoined twins and conjoined triplets: At the heart of the matter	3
Prophylactic use of cardiac medications for delay of left ventricular dysfunction in Duchenne muscular dystrophy	3
Genitourinary infection and gastroschisis: A systematic review and meta‐analysis	3
Folate and vitamin B₁₂ status and predicted neural tube defects risk among nonpregnant women of reproductive age from the Malawi National Micronutrient Survey, 2015–20	3
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Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population	3
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Association of MTHFR (C677T, A1298C) and MTRR A66G polymorphisms with fatty acids profile and risk of neural tube defects	3
Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997–2011	3
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Describing characteristics of adults with and without congenital heart defects hospitalized with COVID‐19	3
Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein–protein interaction netw	3
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A Case of a Fetus With SETD5 Mutation: Prenatal Phenotype and Literature Review	3
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The timing, duration, and severity of nausea and vomiting of pregnancy and adverse birth outcomes among controls without birth defects in the National Birth Defects Prevention Study	3
Integration and application of new approach methodologies in assessing the developmental hazards: Case study with an antimalarial drug	3
Natural history study of Pseudoachondroplasia: A focus on oral health	3
Society for Birth Defects Research and Prevention Symposium: Health Disparities Within Communities of Color	3
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Risk factors and characteristics of the birth of patients with craniofacial microsomia, a case–control study	3
Bladder augmentation in exstrophy vesicae: Long‐term results of a single experienced center	3
Investigating the association between vitamin D dietary intake during pregnancy and incidence of clubfoot in neonates	3
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Observed Prevalence of Congenital Situs Inversus in the United States Before and During the SARS‐CoV‐2 Pandemic, 2017–2022	3
The relationship between maternal periconceptional micronutrient supplementation and non‐syndromic cleft lip/palate in offspring	3
Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries	3
High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction	3
Evaluation of gadolinium‐based contrast agents in pregnant CD‐1 mice and subsequent in utero exposure of the developing offspring, including behavioral evaluations	2
PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab	2
Mechanical dissection and culture of mouse cranial neural crest cells	2
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Childhood Educational Outcomes of Infants Born With Esophageal Atresia With or Without Tracheoesophageal Fistula	2
Measuring misclassification and sample bias in passive surveillance systems: Improving prevalence estimates of critical congenital heart defects in state‐based passive surveillance systems	2
Animal evidence considered in determination of cannabis smoke and Δ⁹‐tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint); Part I. Somatic development	2
Children With Biliary Atresia Have Substantial Morbidity in Early Childhood and a High Risk of Liver Transplantation	2
Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA	2
Exercise FITT‐V during pregnancy: Association with birth outcomes	2
BDR Reviewer Thank You	2
Lead brownfields and birth defects in North Carolina 2003–2015: A cross‐sectional case–control study	2
Issue Information	2
Fever and antibiotic use in maternal urinary tract infections during pregnancy and risk of congenital heart defects: Findings from the National Birth Defects Prevention Study	2
Embryonic Vascular Dysgenesis: The Origin of Proximal Femoral Focal Deficiency	2
Public health priorities for gastroschisis: Summary of a meeting sponsored by the Centers for Disease Control and Prevention and the March of Dimes	2
Prenatal immobility stress: Relationship with oxidative stress, inflammation, apoptosis, and intrauterine growth restriction in rats	2
An example of parenchymal renal sparing in the context of complex malformations due to a novel mutation in the PBX1 gene	2
Animal evidence considered in determination of cannabis smoke and Δ⁹‐tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint): Part III. Proposed	2
Review: Hormone Pregnancy Tests Were Teratogenic by the Same Failed Abortion and Hypoxia‐Related Mechanism as Misoprostol	2
Increased incidence of renal and urinary tract anomalies among individuals with fetal alcohol spectrum disorders (FASD)	2
Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter	2
Prevalence of Congenital Ocular Anomalies in 15 Countries of Europe: Results From the Medikeye Study	2
New classification of the penoscrotal positional anomalies	2
The Influence of Maternal Melatonin on Embryo Implantation: A Crucial Factor in Reproductive Outcomes	2
COVID‐19 Vaccination During Pregnancy and Birth Defects: Results From the CDC COVID‐19 Vaccine Pregnancy Registry, United States 2021–2022	2
National population‐based estimates for major birth defects, 2016–2020	2
Impact of perinatal exposure counseling on patient reported emotional outcomes and decisional empowerment	2
Assessing Environmental Justice in Mexico: How Polluting Industries and Healthcare Disparities Impact Congenital Heart Defects	2
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The Effect of Some Complementary Medicine Active Components on Rat Embryonic Heart Rate In Vitro	2
First trimester COVID‐19 and the risk of major congenital malformations–International Registry of Coronavirus Exposure in Pregnancy	2
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COL1A1 regulates the apoptosis of embryonic stem cells by mediating the PITX1/TBX4 signaling	2
Hydranencephaly following carbon monoxide poisoning during pregnancy: An uncommon and potentially fatal complication in infant	2
Novel Homozygous DLX5 and WNT10B Variants Expand the Genetic and Phenotypic Spectrum of Autosomal	2
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Reproductive and neurobehavioral effects of dinotefuran in an F₁‐generation toxicity study in mice	2
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Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split‐Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study	2
High‐throughput detection of craniofacial defects in fluorescent zebrafish	2
Correction to Food Fortification Ineffective in Preventing Neural Tube Defects in India due to Regulation Promoting Inadequate Levels of Folic Acid and Vitamin B12	2
A machine learning model for predicting congenital heart defects from administrative data	2
Functional Evaluation of Neural Tube Defect‐Related Missense Mutations Using In Silico Methods	2
Case–Control Study of Congenital Anomalies: Study Methods and Nonresponse Bias Assessment	2
HESI workshop summary: Interpretation of developmental and reproductive toxicity endpoints and the impact on data interpretation of adverse events	2
Risk of birth defects in pregnant persons with sleep‐disordered breathing during pregnancy	2
Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory	2
Reduction of infant mortality from congenital heart defects in a middle‐income country: Costa Rican experience	2
Food Fortification Ineffective in Preventing Neural Tube Defects in India due to Regulation Promoting Inadequate Levels of Folic Acid and Vitamin B12	2
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