Science Immunology

(The TQCC of Science Immunology is 35. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome777
The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients734
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19657
Comprehensive mapping of immune perturbations associated with severe COVID-19648
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients634
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination526
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients514
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients460
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome393
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths358
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients344
Natural killer cell immunotypes related to COVID-19 disease severity337
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19286
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19268
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence239
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients231
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants227
SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection223
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles207
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19190
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients183
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination183
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells178
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype167
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19163
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection160
Prolonged evolution of the human B cell response to SARS-CoV-2 infection157
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis154
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics154
A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response149
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes149
SARS-CoV-2 infection generates tissue-localized immunological memory in humans149
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection148
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation143
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses142
Human inborn errors of immunity: An expanding universe140
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19138
Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis137
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses136
Pharmacological activation of STING blocks SARS-CoV-2 infection134
MAIT cell activation and dynamics associated with COVID-19 disease severity134
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2134
TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells131
Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19127
The known unknowns of T cell immunity to COVID-19125
Tissue-resident CD4 + T helper cells assist the development of protective respiratory B and CD8 + T cell memory responses124
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation120
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19119
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19114
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity113
SARS-CoV-2 seroprevalence among parturient women in Philadelphia111
Human dendritic cells in cancer111
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy110
Bispecific antibodies targeting mutant RAS neoantigens110
Innate immunological pathways in COVID-19 pathogenesis109
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma108
Polyclonal expansion of TCR Vβ 21.3 + CD4 + and CD8 + T cells is a hallmark of multisystem infl106
Immune signatures underlying post-acute COVID-19 lung sequelae106
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection105
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination105
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity98
Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer95
3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates95
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection93
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation92
T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection92
T cell factor 1: A master regulator of the T cell response in disease91
T resident helper cells promote humoral responses in the lung91
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine90
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct90
Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation89
Understanding T cell responses to COVID-19 is essential for informing public health strategies89
The expansion of human T-bet high CD21 low B cells is T cell dependent87
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer86
Persistence of mature dendritic cells, T H 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade85
COVID-19 vaccine side effects: The positives about feeling bad85
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA85
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection85
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer85
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques82
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses82
Transcriptomic and clonal characterization of T cells in the human central nervous system81
Itaconate controls the severity of pulmonary fibrosis81
Transforming growth factor–β1 in regulatory T cell biology79
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques79
CXCL9 and CXCL10 bring the heat to tumors78
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice77
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease77
Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia77
Coral gasdermin triggers pyroptosis74
Cellular context of IL-33 expression dictates impact on anti-helminth immunity74
The circadian immune system72
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity72
Lack of CD8 + T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer69
IL-17 controls central nervous system autoimmunity through the intestinal microbiome69
Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue69
Oral epithelial IL-22/STAT3 signaling licenses IL-17–mediated immunity to oral mucosal candidiasis67
Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape66
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases66
Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis65
Spatially mapping the immune landscape of melanoma using imaging mass cytometry64
A common framework of monocyte-derived macrophage activation64
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy64
The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity63
NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity63
Operation Nasal Vaccine—Lightning speed to counter COVID-1961
T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity61
Pathogen-induced tissue-resident memory T H 17 (T RM 17) cells amplify autoimmune kidney disease60
Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages60
Classification of human chronic inflammatory skin disease based on single-cell immune profiling59
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion59
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation57
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation57
Early cross-coronavirus reactive signatures of humoral immunity against COVID-1957
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation57
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer56
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates56
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity56
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood55
Clonally expanded, GPR15-expressing pathogenic effector T H 2 cells are associated with eosinophilic esophagitis55
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation54
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR153
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma53
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes53
Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage52
Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation50
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths50
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy49
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages48
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation48
Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection48
Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR1547
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target47
Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells47
Persistent STAT5 activation reprograms the epigenetic landscape in CD4 + T cells to drive polyfunctionality and antitumor immunity47
Immune surveillance of the liver by T cells46
Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.546
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein45
Resident memory T cells form during persistent antigen exposure leading to allograft rejection45
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection45
The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis44
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium43
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors43
TREM2 macrophages induced by human lipids drive inflammation in acne lesions43
Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells43
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles42
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants42
The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells42
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity42
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination42
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-1941
Glycolipid-peptide vaccination induces liver-resident memory CD8 + T cells that protect against rodent malaria41
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation41
A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses41
Size-dependent activation of CAR-T cells40
Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells40
Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases39
Functional heterogeneity of alveolar macrophage population based on expression of CXCL239
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency39
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission39
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis39
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines38
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation37
Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells37
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity37
HLA-E–restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities37
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern36
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens36
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding36
The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation36
A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa35
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion35
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques35
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response35
Targeting monoamine oxidase A for T cell–based cancer immunotherapy35
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants35