Science Immunology

Article	Citations
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19	667
Comprehensive mapping of immune perturbations associated with severe COVID-19	652
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients	635
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination	529
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients	514
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients	463
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome	393
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths	365
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients	350
Natural killer cell immunotypes related to COVID-19 disease severity	338
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19	275
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence	240
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients	232
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants	229
SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection	224
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles	217
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19	191
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	189
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients	187
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells	179
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	169
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19	165
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection	162
A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response	158
Prolonged evolution of the human B cell response to SARS-CoV-2 infection	158

Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics	157
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis	156
SARS-CoV-2 infection generates tissue-localized immunological memory in humans	154
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection	151
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes	150
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses	146
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation	146
Human inborn errors of immunity: An expanding universe	145
Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis	141
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19	140
Pharmacological activation of STING blocks SARS-CoV-2 infection	137
TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells	137
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses	137
MAIT cell activation and dynamics associated with COVID-19 disease severity	136
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2	134
Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19	128
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation	127
The known unknowns of T cell immunity to COVID-19	126
Tissue-resident CD4 + T helper cells assist the development of protective respiratory B and CD8 + T cell memory responses	125
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19	119
Human dendritic cells in cancer	117
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy	117
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19	116
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity	115
SARS-CoV-2 seroprevalence among parturient women in Philadelphia	112
Innate immunological pathways in COVID-19 pathogenesis	111
Bispecific antibodies targeting mutant RAS neoantigens	110
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	109
Immune signatures underlying post-acute COVID-19 lung sequelae	108
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection	107
Polyclonal expansion of TCR Vβ 21.3 + CD4 + and CD8 + T cells is a hallmark of multisystem infl	107
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity	103
Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer	101
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	100
T cell factor 1: A master regulator of the T cell response in disease	96
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer	94
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation	94
T resident helper cells promote humoral responses in the lung	92
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct	91
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	90
Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation	90
Understanding T cell responses to COVID-19 is essential for informing public health strategies	90
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	89
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA	88
The expansion of human T-bet high CD21 low B cells is T cell dependent	88
Persistence of mature dendritic cells, T H 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade	87
COVID-19 vaccine side effects: The positives about feeling bad	87
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection	86
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses	84
Transforming growth factor–β1 in regulatory T cell biology	83

Itaconate controls the severity of pulmonary fibrosis	82
CXCL9 and CXCL10 bring the heat to tumors	82
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques	82
Transcriptomic and clonal characterization of T cells in the human central nervous system	82
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques	81
Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia	78
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease	77
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice	77
Coral gasdermin triggers pyroptosis	75
Cellular context of IL-33 expression dictates impact on anti-helminth immunity	75
The circadian immune system	75
Lack of CD8 + T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer	72
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity	72
IL-17 controls central nervous system autoimmunity through the intestinal microbiome	71
Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue	69
A common framework of monocyte-derived macrophage activation	69
Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape	68
NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity	67
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases	67
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy	66
Spatially mapping the immune landscape of melanoma using imaging mass cytometry	66
The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity	65
Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis	65
T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity	63
Operation Nasal Vaccine—Lightning speed to counter COVID-19	62
Pathogen-induced tissue-resident memory T H 17 (T RM 17) cells amplify autoimmune kidney disease	61
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion	61
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation	61
Classification of human chronic inflammatory skin disease based on single-cell immune profiling	61
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation	60
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	60
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity	60
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19	58
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer	58
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	57
Clonally expanded, GPR15-expressing pathogenic effector T H 2 cells are associated with eosinophilic esophagitis	57
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma	57
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood	57
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates	57
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1	54
Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage	54
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes	54
Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection	52
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation	52
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages	52
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths	52
Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation	51
Immune surveillance of the liver by T cells	49
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy	49
Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5	48
Persistent STAT5 activation reprograms the epigenetic landscape in CD4 + T cells to drive polyfunctionality and antitumor immunity	48
Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells	48
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target	48
Resident memory T cells form during persistent antigen exposure leading to allograft rejection	47
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination	47
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection	46
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors	46
The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis	46
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	46
The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells	44
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	44
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19	44
TREM2 macrophages induced by human lipids drive inflammation in acne lesions	44
Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells	44
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles	44
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium	44
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation	43
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding	42
A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses	42
Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases	42
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity	42
Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells	41
Size-dependent activation of CAR-T cells	41
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis	40
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	40
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2	40
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation	39
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency	39
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	39
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	39

Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells	38
HLA-E–restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities	37
Selective STING stimulation in dendritic cells primes antitumor T cell responses	37
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity	37
Single-cell analysis pinpoints distinct populations of cytotoxic CD4 + T cells and an IL-10 + CD109 +	36
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9	36
The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation	36
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	36
Targeting monoamine oxidase A for T cell–based cancer immunotherapy	36
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response	36
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion	36
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques	35
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants	35
Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation	35
Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells	35
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood	35
A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa	35
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	35