Science Immunology

Article	Citations
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	497
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	450
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	378
The HLA advantage: Why COVID-19 benched you but not your co-worker	334
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	331
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	261
Intratumoral immunotherapy relies on B and T cell collaboration	260
RORγt-lineage APCs: The Aire apparent	249
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	232
Is one lymphocyte’s brake another lymphocyte’s gas?	192
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation	183
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	182
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	179
Operation Nasal Vaccine—Lightning speed to counter COVID-19	174
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	174
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	170
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	169
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	166
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	161
ILC2s—Bipartisan politicians in cancer	159
Neither naïve nor anergic, “autoimmune” not allergic	158
Antibody-mediated immunity against lung cancer goes retro	151
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	149
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	149
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	145

Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9	137
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	137
Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis	131
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	131
CMV, MHC-E, and the quest for an unconventional AIDS vaccine	131
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	127
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	127
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	124
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19	120
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	116
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24	115
DuraBle tolerance to CNS antigens	114
Anti-body antibodies in COVID-19	113
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	110
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	104
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	103
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	100
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	99
Single-cell analysis pinpoints distinct populations of cytotoxic CD4 + T cells and an IL-10 + CD109 +	97
The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis	97
Subsetting the subsets: Heterogeneity and developmental relationships of T cells in human tumors	96
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	95
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity	93
RNA exosome drives early B cell development via noncoding RNA processing mechanisms	90
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4 +	87
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge	86
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	85
Dynamic STING repression orchestrates immune cell development and function	83
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	82
The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation	80
Immune determinants of chronic sequelae after respiratory viral infection	80
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation	77
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells	76
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	75
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	75
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	72
Androgen effects cause sex-biased impairment of CD8 + T cell antitumor activity	71
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	71
Unearthing the Rosetta Stone of public antibody responses	70
IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells	68
Tissue-specific nonheritable influences drive endometrial immune system variation	67
CAR keys to unlock the intracellular immunopeptidome	67
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8 + T cells lacking a gut-homing phenotype	67
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	67
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	66
Gutsy memory T cells stand their ground against pathogens	66
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	65
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	63
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	62
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	62

Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation	62
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques	61
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	61
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	61
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation	61
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	60
Immune signatures underlying post-acute COVID-19 lung sequelae	59
Functional differences between rodent and human PD-1 linked to evolutionary divergence	59
Early human lung immune cell development and its role in epithelial cell fate	59
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	59
Effective CD4 T cell priming requires repertoire scanning by CD301b + migratory cDC2 cells upon lymph node entry	59
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function	59
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	58
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19	58
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	58
Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	58
Histone demethylation tones down leukemia through innate immunity	57
An e-Xist-ential two-edged sword for women	57
Platelets and mast cells say “HIAA” to welcome in neutrophils	57
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	56
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. Lucas	55
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage	55
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	55
OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis	55
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	55
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	55
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	55
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	53
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease	52
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	52
Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization	52
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency	51
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	51
Transforming growth factor–β1 in regulatory T cell biology	50
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	49
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	49
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	49
EBVerified TCRs and multiple sclerosis	49
Finding TB vaccine antigens: follow the TCRs	48
Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology	48
Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency	48
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	47
c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome	46
Targeting TLR4 during vaccination boosts MAdCAM-1 + lymphoid stromal cell activation and promotes the aged germinal center response	46
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration	45
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	45
Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β–converting enzyme	45
FOXP3 exon 2 controls T reg stability and autoimmunity	45
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	45
The circadian immune system	44
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19	44
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	44
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	44
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability	44
It’s good to have Gremlins in the zone	43
Welcoming c-MAF to the macrophage transcription factor VAM-ily	43
Plasmablasts from the past: Nostalgic B cells can’t let go	43
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection	43
A SPARC-ling link to inflammaging	43
T regs and inflammation—bring it on!	43
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	42
The gene regulatory basis of bystander activation in CD8 + T cells	42
Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory	42
ExtrathymicAire-expressing cells support maternal-fetal tolerance	42
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	41
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	41
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells	41
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage	41
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	41
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	40
LXR signaling controls homeostatic dendritic cell maturation	40
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	40
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	40
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	40
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	40
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity	40
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	40
Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity	40
TCRward personalized transplant therapies	39
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	39

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	39
Only pregnant moms can do it….	39
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	39
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	39
Mitochondria—More than just ATP for CTLs	39
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	39
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	38
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	38
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	38
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	38
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients	38
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	38
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	37
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	37
GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures	37
See no allergen, hear no allergen, speak no allergen!	37
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	37
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	36
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	36
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	36
NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation	36
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	36
Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis	36
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	36