Science Immunology

Papers
(The median citation count of Science Immunology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination545
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients471
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome397
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths392
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients359
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19291
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants248
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence246
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles239
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients236
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination206
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients189
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells188
A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response175
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19175
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype173
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics172
Prolonged evolution of the human B cell response to SARS-CoV-2 infection166
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection164
SARS-CoV-2 infection generates tissue-localized immunological memory in humans163
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes160
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection154
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation150
Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis147
Pharmacological activation of STING blocks SARS-CoV-2 infection145
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19145
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses140
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation140
Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19137
Tissue-resident CD4 + T helper cells assist the development of protective respiratory B and CD8 + T cell memory responses135
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2135
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy133
The known unknowns of T cell immunity to COVID-19128
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19128
Human dendritic cells in cancer126
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection125
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19125
Innate immunological pathways in COVID-19 pathogenesis125
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity124
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination122
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer117
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity117
Bispecific antibodies targeting mutantRASneoantigens117
Immune signatures underlying post-acute COVID-19 lung sequelae116
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection115
Polyclonal expansion of TCR Vβ 21.3+CD4+and CD8+T cells is a hallmark of multisystem inflammatory syndrome in children111
Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer110
T cell factor 1: A master regulator of the T cell response in disease109
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation101
CXCL9 and CXCL10 bring the heat to tumors100
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer100
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct100
T resident helper cells promote humoral responses in the lung97
The expansion of human T-bet high CD21 low B cells is T cell dependent96
Transforming growth factor–β1 in regulatory T cell biology96
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA95
Understanding T cell responses to COVID-19 is essential for informing public health strategies95
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection94
Persistence of mature dendritic cells, T H 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade93
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses92
COVID-19 vaccine side effects: The positives about feeling bad91
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine91
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques91
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques85
Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia84
Cellular context of IL-33 expression dictates impact on anti-helminth immunity83
The circadian immune system83
Coral gasdermin triggers pyroptosis83
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity82
Lack of CD8 + T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer80
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation79
NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity77
Spatially mapping the immune landscape of melanoma using imaging mass cytometry75
IL-17 controls central nervous system autoimmunity through the intestinal microbiome74
A common framework of monocyte-derived macrophage activation74
Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape73
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases72
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy71
Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue69
The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity69
Operation Nasal Vaccine—Lightning speed to counter COVID-1969
Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis68
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma68
Classification of human chronic inflammatory skin disease based on single-cell immune profiling67
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation66
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion66
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer65
Clonally expanded, GPR15-expressing pathogenic effector T H 2 cells are associated with eosinophilic esophagitis65
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation64
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity63
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood61
Early cross-coronavirus reactive signatures of humoral immunity against COVID-1960
Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection60
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates60
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation59
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes57
Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation57
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths57
Size-dependent activation of CAR-T cells56
Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage55
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation53
Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells53
The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis53
Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.552
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination52
Resident memory T cells form during persistent antigen exposure leading to allograft rejection52
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy52
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target52
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors52
TREM2 macrophages induced by human lipids drive inflammation in acne lesions50
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation49
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein49
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation48
Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases48
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium48
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants47
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity46
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles46
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-1946
Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells45
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines44
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis43
The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation43
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency43
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants42
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission42
HLA-E–restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities42
Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells41
Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation41
Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer41
Selective STING stimulation in dendritic cells primes antitumor T cell responses41
Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells41
Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria41
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein41
A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa40
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 540
Single-cell analysis pinpoints distinct populations of cytotoxic CD4 + T cells and an IL-10 + CD109 + 40
An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment40
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/940
Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation39
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements39
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus39
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern39
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response39
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood39
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity39
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis39
Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells38
OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment38
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability38
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells38
FOXP3 exon 2 controls T reg stability and autoimmunity37
Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism37
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion37
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis37
Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus37
Cytomegaloviral determinants of CD8 + T cell programming and RhCMV/SIV vaccine efficacy37
Targeting monoamine oxidase A for T cell–based cancer immunotherapy37
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation36
BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors36
TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy36
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques36
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens36
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis35
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-2435
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses35
Human cytomegalovirus expands a CD8 + T cell population with loss of BCL11B expression and gain of NK cell identity35
Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling35
CD4 + T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis35
CD103 fate mapping reveals that intestinal CD103tissue-resident memory T cells are the primary responders to secondary infection35
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer34
Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis34
The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair34
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage34
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity34
Epstein-Barr virus as a driver of multiple sclerosis34
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation34
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage34
Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential33
Tumors resurrect an embryonic vascular program to escape immunity33
Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers32
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma32
Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 + CD8 + T regs32
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells32
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs31
Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.131
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans31
The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit31
Bile acid–sensitive tuft cells regulate biliary neutrophil influx31
Single-cell deletion analyses show control of pro–T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b31
Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity31
Developmental bifurcation of human T follicular regulatory cells31
Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities31
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia31
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation31
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes30
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy30
c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome30
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells30
Long-lived plasma cells accumulate in the bone marrow at a constant rate from early in an immune response30
Metabolic challenges and interventions in CAR T cell therapy30
Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters29
PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance29
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis29
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection29
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells29
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool29
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs29
All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages29
Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems29
A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection29
Competition for refueling rather than cyclic reentry initiation evident in germinal centers29
E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates29
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration28
BATF promotes group 2 innate lymphoid cell–mediated lung tissue protection during acute respiratory virus infection28
Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection28
Recall of B cell memory depends on relative locations of prime and boost immunization28
The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity28
Batf-mediated epigenetic control of effector CD8 + T cell differentiation28
Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci28
Rgs16 promotes antitumor CD8 + T cell exhaustion28
Antigen identification for HLA class I– and HLA class II–restricted T cell receptors using cytokine-capturing antigen-presenting cells27
Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA227
Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β–converting enzyme27
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity27
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study27
A circulating subset of iNKT cells mediates antitumor and antiviral immunity27
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability26
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif26
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function26
Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility26
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells25
Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals25
Human T follicular helper clones seed the germinal center–resident regulatory pool25
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome25
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice25
Cis interactions between CD2 and its ligands on T cells are required for T cell activation25
Immune determinants of chronic sequelae after respiratory viral infection24
Macrophage compartmentalization in the brain and cerebrospinal fluid system24
Targeting TLR4 during vaccination boosts MAdCAM-1 + lymphoid stromal cell activation and promotes the aged germinal center response24
Anti–PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases24
LXR signaling controls homeostatic dendritic cell maturation24
IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation24
Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support24
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue24
Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity23
A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis23
Deep-sea microbes as tools to refine the rules of innate immune pattern recognition23
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome23
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells23
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