Science Immunology

Article	Citations
Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome	771
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes	770
The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients	724
Comprehensive mapping of immune perturbations associated with severe COVID-19	642
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19	642
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients	620
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination	515
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients	503
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients	449
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome	389
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths	337
Natural killer cell immunotypes related to COVID-19 disease severity	324
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients	322
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19	285
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19	253
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence	236
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients	224
SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection	223
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants	220
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19	184
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients	179
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 + T cells	175
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	170
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles	170
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	165

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection	158
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19	158
Prolonged evolution of the human B cell response to SARS-CoV-2 infection	152
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics	146
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis	145
SARS-CoV-2 infection generates tissue-localized immunological memory in humans	144
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes	143
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection	140
Human inborn errors of immunity: An expanding universe	136
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation	136
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses	135
Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis	133
MAIT cell activation and dynamics associated with COVID-19 disease severity	131
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses	131
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19	131
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2	131
A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response	128
Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward	126
TOX is expressed by exhausted and polyfunctional human effector memory CD8 + T cells	125
Pharmacological activation of STING blocks SARS-CoV-2 infection	125
Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19	124
Early precursors and molecular determinants of tissue-resident memory CD8 + T lymphocytes revealed by single-cell RNA sequencing	121
The known unknowns of T cell immunity to COVID-19	120
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19	116
Tissue-resident CD4 + T helper cells assist the development of protective respiratory B and CD8 + T cell memory responses	114
SARS-CoV-2 seroprevalence among parturient women in Philadelphia	110
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19	108
Bispecific antibodies targeting mutant RAS neoantigens	106
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity	105
Innate immunological pathways in COVID-19 pathogenesis	104
Polyclonal expansion of TCR Vβ 21.3 + CD4 + and CD8 + T cells is a hallmark of multisystem infl	104
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma	102
Immune signatures underlying post-acute COVID-19 lung sequelae	101
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation	101
Human dendritic cells in cancer	100
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy	99
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair	98
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection	98
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	93
3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates	89
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity	89
T cell factor 1: A master regulator of the T cell response in disease	88
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer	87
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	87
T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection	87
Understanding T cell responses to COVID-19 is essential for informing public health strategies	86
Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation	86
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	86
Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes	86
Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer	85

T resident helper cells promote humoral responses in the lung	83
HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19	83
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation	82
COVID-19 vaccine side effects: The positives about feeling bad	81
The expansion of human T-bet high CD21 low B cells is T cell dependent	81
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection	79
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses	78
Persistence of mature dendritic cells, T H 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade	78
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA	77
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	76
Transforming growth factor–β1 in regulatory T cell biology	76
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques	76
Transcriptomic and clonal characterization of T cells in the human central nervous system	76
The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer	75
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice	75
Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia	75
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct	74
Itaconate controls the severity of pulmonary fibrosis	73
Cellular context of IL-33 expression dictates impact on anti-helminth immunity	72
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques	71
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease	69
Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue	68
IL-17 controls central nervous system autoimmunity through the intestinal microbiome	67
A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain	66
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases	65
CXCL9 and CXCL10 bring the heat to tumors	65
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity	65
Oral epithelial IL-22/STAT3 signaling licenses IL-17–mediated immunity to oral mucosal candidiasis	64
Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape	64
Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy	64
Coral gasdermin triggers pyroptosis	63
Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis	63
Gut-resident CX3CR1 hi macrophages induce tertiary lymphoid structures and IgA response in situ	62
The circadian immune system	61
Spatially mapping the immune landscape of melanoma using imaging mass cytometry	61
Lack of CD8 + T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer	60
The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity	59
T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity	59
Pathogen-induced tissue-resident memory T H 17 (T RM 17) cells amplify autoimmune kidney disease	57
A common framework of monocyte-derived macrophage activation	57
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19	57
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion	57
NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity	56
Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages	56
Salivary gland macrophages and tissue-resident CD8 + T cells cooperate for homeostatic organ surveillance	56
Operation Nasal Vaccine—Lightning speed to counter COVID-19	56
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates	53
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	52
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation	52
Classification of human chronic inflammatory skin disease based on single-cell immune profiling	52
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer	51
A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood	51
Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1	50
Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage	50
IRF5 guides monocytes toward an inflammatory CD11c + macrophage phenotype and promotes intestinal inflammation	49
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	49
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity	48
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy	48
Clonally expanded, GPR15-expressing pathogenic effector T H 2 cells are associated with eosinophilic esophagitis	48
Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation	47
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes	47
Acetylcholine production by group 2 innate lymphoid cells promotes mucosal immunity to helminths	46
M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis	46
Immune surveillance of the liver by T cells	46
Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells	46
Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization	46
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation	45
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages	45
Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5	44
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection	44
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma	44
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation	43
The m 6 A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis	43
Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR15	43
Resident memory T cells form during persistent antigen exposure leading to allograft rejection	43
Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells	41
Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection	41
Glycolipid-peptide vaccination induces liver-resident memory CD8 + T cells that protect against rodent malaria	41
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination	41
A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses	40

Persistent STAT5 activation reprograms the epigenetic landscape in CD4 + T cells to drive polyfunctionality and antitumor immunity	40
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity	40
The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells	39
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	39
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation	39
KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target	39
TREM2 macrophages induced by human lipids drive inflammation in acne lesions	39
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium	39
Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles	38
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2	38
Size-dependent activation of CAR-T cells	38
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	38
The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity	37
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	37
Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases	36
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors	36
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	36
An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis	35
Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency	35
Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells	35
HLA-E–restricted, Gag-specific CD8 + T cells can suppress HIV-1 infection, offering vaccine opportunities	35
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19	35
Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells	35
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding	35
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	34
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9	34
The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation	34
A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa	34
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response	34
Cytomegaloviral determinants of CD8 + T cell programming and RhCMV/SIV vaccine efficacy	33
CD4 + T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis	33
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation	33
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	33
A distinct GM-CSF + T helper cell subset requires T-bet to adopt a T H 1 phenotype and promote neuroinflammation	33
Epstein-Barr virus as a driver of multiple sclerosis	33
Targeting monoamine oxidase A for T cell–based cancer immunotherapy	33
Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 + T cells	33
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques	33
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion	33
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage	32
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants	32
Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease	31
Single-cell analysis pinpoints distinct populations of cytotoxic CD4 + T cells and an IL-10 + CD109 +	31
IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis	31
OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment	31
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	30
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage	30
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells	30
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood	30
An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment	29
Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells	29
Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria	28
Rhythmicity of intestinal IgA responses confers oscillatory commensal microbiota mutualism	28
Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation	28
Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration	28
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein	28
c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome	28
Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation	28
Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1	28
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection	27
Noncanonical splicing junctions between exons and transposable elements represent a source of immunogenic recurrent neo-antigens in patients with lung cancer	27
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs	27
Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells	27
Tumors resurrect an embryonic vascular program to escape immunity	27
Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling	27
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity	27
Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3 + CD8 + T regs	27
Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis	27
BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors	26
TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy	26
IL-22–induced cell extrusion and IL-18–induced cell death prevent and cure rotavirus infection	26
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation	26
Competition for refueling rather than cyclic reentry initiation evident in germinal centers	26
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans	26
Bile acid–sensitive tuft cells regulate biliary neutrophil influx	25
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24	25
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs	25
E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates	25
Human cytomegalovirus expands a CD8 + T cell population with loss of BCL11B expression and gain of NK cell identity	24
Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity	24
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	24
Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers	24
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia	24
The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit	24
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	24
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation	23
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements	23
Rgs16 promotes antitumor CD8 + T cell exhaustion	23
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells	23
The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity	23
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	23
Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals	23
Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2	23
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells	23
Selective STING stimulation in dendritic cells primes antitumor T cell responses	23