Science Immunology

Article	Citations
The HLA advantage: Why COVID-19 benched you but not your co-worker	353
Is one lymphocyte’s brake another lymphocyte’s gas?	334
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	317
Characterization of the mammalian prodefinitive angio-hematopoietic lineage	293
RORγt-lineage APCs: The Aire apparent	251
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity	204
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	178
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	174
Structural variation tunes apoptotic responses to drive immune escape in melanoma	156
Operation Nasal Vaccine—Lightning speed to counter COVID-19	136
The OAS–RNase L pathway: Insights from experiments of nature	136
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	133
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	131
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	131
Atlas of human gut-associated lymphoid tissue reveals immunomodulatory interactions of B cells	124
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	123
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	120
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	119
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	117
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	116
Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity	115
DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function	110
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	109
Neither naïve nor anergic, “autoimmune” not allergic	107
Antibody-mediated immunity against lung cancer goes retro	106

The rise of spatial TCR profiling: Emerging technologies and open challenges	106
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	103
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	101
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	101
Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models	99
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins	98
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	97
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	92
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	92
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	90
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	89
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ	89
B cells gone broad: A deep dive into SARS-CoV-2 antibody breadth	88
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	88
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	87
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4	87
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance	85
Tissue origin and virus specificity shape human CD8 + T cell cytotoxicity	84
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	82
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	82
Erratum for the Research Article “Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer”	81
A breath of fresh AIR in novel CAR T cell design	80
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	79
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	79
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	79
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	79
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	78
Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life	78
Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen	78
Dynamic STING repression orchestrates immune cell development and function	77
Unearthing the Rosetta Stone of public antibody responses	76
Gutsy memory T cells stand their ground against pathogens	76
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	75
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	75
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	75
Tissue-specific nonheritable influences drive endometrial immune system variation	74
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	74
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors	73
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	72
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	72
Intratumoral T reg cell ablation elicits NK cell–mediated control of CD8 T cell–resistant tumors	72
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system	71
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	70
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	69
Early human lung immune cell development and its role in epithelial cell fate	69
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	67
Memories that endure	67
Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	66
Functional differences between rodent and human PD-1 linked to evolutionary divergence	66
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	66

Histone demethylation tones down leukemia through innate immunity	65
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	65
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	65
An e-Xist-ential two-edged sword for women	65
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	65
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. L	64
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	63
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	63
EBVerified TCRs and multiple sclerosis	63
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine	62
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	62
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes	62
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	62
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	61
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer	61
B cells drive CD4 T cell immunosenescence and age-associated health decline	61
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	60
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	59
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	59
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	59
Finding TB vaccine antigens: follow the TCRs	58
The epitope tax: Antibody feedback and the economics of germinal center competition	58
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	56
GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation	56
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	56
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	55
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	55
Immune signature clues are key to unlocking the mystery of clinical responses	55
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	55
A SPARC-ling link to inflammaging	55
EBV grants B cells a license for immortality in the CNS	54
Plasmablasts from the past: Nostalgic B cells can’t let go	54
B cells and dengue: A cat-and-mouse game	53
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	52
Langerhans cell control of early-life dermal lymphatic development shapes adult immunity	52
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	51
Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis	51
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	51
Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense	51
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells	51
Pathogenic IgE-fated memory B cell responses retain functional plasticity	51
The gene regulatory basis of bystander activation in CD8 + T cells	50
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	50
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	50
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	49
TCRward personalized transplant therapies	49
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	49
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	49
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	49
LXR signaling controls homeostatic dendritic cell maturation	49
RORγt + dendritic cells are a distinct lymphoid-derived lineage	48
How dengue defies dogma: An extrafollicular tale	48
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	48
The 10 commandments of immunoregulation in lymphoma	48
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B	47
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	47
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	47
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	47
Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells	47
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	46
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages	46
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	46
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	46
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model	46
Nuclear polarization to the immune synapse facilitates an early transcriptional burst	45
See no allergen, hear no allergen, speak no allergen!	45
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	45
Gastrointestinal tuft cells: Recent insights and next questions	44
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	44
NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages	44
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes	43
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	43
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	43
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	42
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development	42
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	42
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	42
Brain sensing of metabolic state regulates circulating monocytes	42
CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury	42
Usp22 is an intracellular regulator of systemic emergency hematopoiesis	42

Evolution of antigen-specific follicular helper T cell transcription from effector function to memory	41
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine	41
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection	41
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates	40
A new tolerogenic cell RORs onto the scene	40
CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy	40
IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2	40
DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements	39
Zfp281 and Zfp148 control CD4 + T cell thymic development and T H 2 functions	39
DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-stranded RNAs	39
Goblet cells tune ILC2 activity through a gut-specific response checkpoint	39
Skull-pting meningeal immunity: Skull bone channels shape neonatal meningeal immune cell trafficking	39
Monocyte-derived IL-10 drives sex differences in pain duration	39
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models	38
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	38
Dynamic regulation of lysine and arginine metabolism promotes immune evasion by limiting T cell function in cancer	38
B cells targeting parasites capture spatially linked antigens to secure T cell help	38
Made to order tuft cells by an OCA-T1 isoform switch	37
Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosis	37
Fishing with autoantibodies nets a gut bacteria that drives arthritis	37
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells	37
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury	37
Tricky Ts play possum to propagate autoimmune disease	37
Size-dependent activation of CAR-T cells	37
CD19 CAR antigen engagement mechanisms and affinity tuning	37
Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner	36
Human T follicular helper clones seed the germinal center–resident regulatory pool	36
Asparagine availability controls germinal center B cell homeostasis	36
An engineered viral protein activates STAT5 to prevent T cell suppression	36
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf	36
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis	35
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis	35
A central role for STAT5 in the transcriptional programing of T helper cell metabolism	35
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity	34
“Training immunity” against nosocomial pathogens	34
Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells	33
Immuno-amnesia: Without B cells, T cells cannot remember	33
Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity	33
IL-10mpting T H 17 cell fate in the gut	33
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	32
“ILC2 it, but I can’t promise anything”	32
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy	32
Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy	32
Age-associated CD4 + T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity	32
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 + T cell formation	32
B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling	31
Gut bacteria–derived serotonin promotes immune tolerance in early life	31
Transient disruption of T cell help impairs germinal center dynamics and memory responses	31
Human life within a narrow range: The lethal ups and downs of type I interferons	31
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes	31
A dynamic atlas of immunocyte migration from the gut	30
Bearing a grudge—How human natural killer cells remember past insults	30
CAR-ving away OX40L with engineered T regs	30
PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells	30
The cold truth about TCR structure	30
Promoting (and targeting) alternative expression	30
SNIPR alert! Making T cells more precise killers	30
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	29
Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα	29
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	29
TB or not TB: That depends on the antibody Fc	29
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	28
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	28
Cis interactions between CD2 and its ligands on T cells are required for T cell activation	27
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	27
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12	27
CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy	27
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	27
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	27
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	27
Metabolic challenges and interventions in CAR T cell therapy	26
Sugar-coated CAR T for sweeter cell therapies	26
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	26
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	26
B cells on the brink	25
Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques	25
MBPeace treaty: How myelin self-peptides broker CNS tolerance	25
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes	25
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity	25
Erratum for the Research Article “Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements” by M. Burbage et al.	24
Apoptotic cells are not all created equal	24
A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis	24
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19	24
Innate receptors with high specificity for HLA class I–peptide complexes	23
NK cells restrain cytotoxic CD8 + T cells in the submandibular gland via PD-1–PD-L1	23
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion	23
T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens	23
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span	23
Cold-blooded vertebrates evolved organized germinal center–like structures	22
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages	22
Heart failure promotes multimorbidity through innate immune memory	22
SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19	22
Intestinal epithelial MHC class II induces encephalitogenic CD4 T cells and initiates central nervous system autoimmunity	22
Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation	22
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma	22