Science Immunology

Article	Citations
The HLA advantage: Why COVID-19 benched you but not your co-worker	337
Is one lymphocyte’s brake another lymphocyte’s gas?	316
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	285
The OAS–RNase L pathway: Insights from experiments of nature	277
Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity	241
Characterization of the mammalian prodefinitive angio-hematopoietic lineage	202
RORγt-lineage APCs: The Aire apparent	202
DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function	195
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity	192
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	159
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	155
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	149
Operation Nasal Vaccine—Lightning speed to counter COVID-19	149
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	148
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	147
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	136
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	134
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	130
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	130
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	125
Structural variation tunes apoptotic responses to drive immune escape in melanoma	118
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	116
Neither naïve nor anergic, “autoimmune” not allergic	115
Antibody-mediated immunity against lung cancer goes retro	114
The rise of spatial TCR profiling: Emerging technologies and open challenges	113

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins	112
ILC2s—Bipartisan politicians in cancer	109
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	107
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	104
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	103
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	101
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	97
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ	97
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	96
Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models	95
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	94
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	93
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	91
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4	90
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	87
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	86
Immune determinants of chronic sequelae after respiratory viral infection	85
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	84
Tissue origin and virus specificity shape human CD8 + T cell cytotoxicity	83
Dynamic STING repression orchestrates immune cell development and function	83
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance	82
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	81
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	81
Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life	80
Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen	80
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	78
B cells gone broad: A deep dive into SARS-CoV-2 antibody breadth	78
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	78
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	77
RNA exosome drives early B cell development via noncoding RNA processing mechanisms	77
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	76
Gutsy memory T cells stand their ground against pathogens	75
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	75
Androgen effects cause sex-biased impairment of CD8 + T cell antitumor activity	74
Unearthing the Rosetta Stone of public antibody responses	73
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	73
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	73
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	73
Intratumoral T reg cell ablation elicits NK cell–mediated control of CD8 T cell–resistant tumors	73
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	72
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8 + T cells lacking a gut-homing phenotype	72
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	71
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	71
Tissue-specific nonheritable influences drive endometrial immune system variation	70
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	69
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system	69
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	69
Early human lung immune cell development and its role in epithelial cell fate	67
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	67
Functional differences between rodent and human PD-1 linked to evolutionary divergence	67

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors	67
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	67
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	66
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	66
Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	66
Histone demethylation tones down leukemia through innate immunity	66
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	62
An e-Xist-ential two-edged sword for women	62
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. L	62
EBVerified TCRs and multiple sclerosis	61
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	61
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	61
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine	60
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes	60
B cells drive CD4 T cell immunosenescence and age-associated health decline	60
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	59
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	59
Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization	59
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	59
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	58
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	58
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	57
Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology	57
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer	57
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	57
Finding TB vaccine antigens: follow the TCRs	57
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	56
The epitope tax: Antibody feedback and the economics of germinal center competition	56
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	56
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	55
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	54
GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation	54
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	54
The circadian immune system	53
Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis	53
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells	53
FOXP3 exon 2 controls T reg stability and autoimmunity	53
Plasmablasts from the past: Nostalgic B cells can’t let go	52
A SPARC-ling link to inflammaging	52
Immune signature clues are key to unlocking the mystery of clinical responses	52
B cells and dengue: A cat-and-mouse game	51
EBV grants B cells a license for immortality in the CNS	51
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	51
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	50
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	50
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	49
LXR signaling controls homeostatic dendritic cell maturation	49
Pathogenic IgE-fated memory B cell responses retain functional plasticity	48
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	48
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	48
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	47
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	47
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model	47
TCRward personalized transplant therapies	47
Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense	47
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	47
RORγt + dendritic cells are a distinct lymphoid-derived lineage	47
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	47
The gene regulatory basis of bystander activation in CD8 + T cells	47
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	46
How dengue defies dogma: An extrafollicular tale	46
The 10 commandments of immunoregulation in lymphoma	46
Only pregnant moms can do it….	46
Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells	45
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	45
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	45
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	44
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages	44
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B	44
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	44
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	44
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	44
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	44
See no allergen, hear no allergen, speak no allergen!	43
NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages	43
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development	43
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	43
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	43
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	42
CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury	42

Usp22 is an intracellular regulator of systemic emergency hematopoiesis	42
Nuclear polarization to the immune synapse facilitates an early transcriptional burst	42
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	41
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	41
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	41
Brain sensing of metabolic state regulates circulating monocytes	41
NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation	41
Gastrointestinal tuft cells: Recent insights and next questions	41
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine	40
Monocyte-derived IL-10 drives sex differences in pain duration	40
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes	40
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	40
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection	40
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory	40
CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy	39
Skull-pting meningeal immunity: Skull bone channels shape neonatal meningeal immune cell trafficking	39
A new tolerogenic cell RORs onto the scene	39
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models	38
DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements	38
Zfp281 and Zfp148 control CD4 + T cell thymic development and T H 2 functions	38
B cells targeting parasites capture spatially linked antigens to secure T cell help	38
IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2	37
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	37
Goblet cells tune ILC2 activity through a gut-specific response checkpoint	37
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells	36
Size-dependent activation of CAR-T cells	36
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	36
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates	36
Tricky Ts play possum to propagate autoimmune disease	35
A central role for STAT5 in the transcriptional programing of T helper cell metabolism	35
Made to order tuft cells by an OCA-T1 isoform switch	35
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf	35
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis	35
Fishing with autoantibodies nets a gut bacteria that drives arthritis	34
Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosis	34
Human T follicular helper clones seed the germinal center–resident regulatory pool	34
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity	33
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis	33
An engineered viral protein activates STAT5 to prevent T cell suppression	33
Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner	33
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury	33
Asparagine availability controls germinal center B cell homeostasis	33
“Training immunity” against nosocomial pathogens	32
CD19 CAR antigen engagement mechanisms and affinity tuning	32
Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells	32
IL-10mpting T H 17 cell fate in the gut	32
Immuno-amnesia: Without B cells, T cells cannot remember	32
B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling	31
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes	31
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 + T cell formation	31
Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy	31
PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells	31
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy	31
Age-associated CD4 + T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity	31
Transient disruption of T cell help impairs germinal center dynamics and memory responses	31
Selfish antibodies target auto-antigens in cancer	30
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	30
Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity	30
Promoting (and targeting) alternative expression	30
Human life within a narrow range: The lethal ups and downs of type I interferons	30
Gut bacteria–derived serotonin promotes immune tolerance in early life	30
A dynamic atlas of immunocyte migration from the gut	30
“ILC2 it, but I can’t promise anything”	30
CAR-ving away OX40L with engineered T regs	29
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	29
Bearing a grudge—How human natural killer cells remember past insults	29
TB or not TB: That depends on the antibody Fc	29
The cold truth about TCR structure	29
SNIPR alert! Making T cells more precise killers	29
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	28
CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy	28
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12	28
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	28
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	28
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	28
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	27
Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα	27
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	27
Cis interactions between CD2 and its ligands on T cells are required for T cell activation	27
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	27
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	26
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	26
Metabolic challenges and interventions in CAR T cell therapy	26
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages	25
Sugar-coated CAR T for sweeter cell therapies	25
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity	25
MBPeace treaty: How myelin self-peptides broker CNS tolerance	25
Apoptotic cells are not all created equal	25
Erratum for the Research Article “Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements” by M. Burbage et al.	25
B cells on the brink	25
Cold-blooded vertebrates evolved organized germinal center–like structures	24
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements	24
Innate receptors with high specificity for HLA class I–peptide complexes	24
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19	24
Intestinal epithelial MHC class II induces encephalitogenic CD4 T cells and initiates central nervous system autoimmunity	24