Science Immunology

Article	Citations
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	406
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	392
Operation Nasal Vaccine—Lightning speed to counter COVID-19	297
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	282
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	240
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	217
Is one lymphocyte’s brake another lymphocyte’s gas?	205
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity	203
RORγt-lineage APCs: The Aire apparent	202
The HLA advantage: Why COVID-19 benched you but not your co-worker	202
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	202
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	193
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	188
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	175
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	162
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	161
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	155
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	153
Intratumoral immunotherapy relies on B and T cell collaboration	149
Neither naïve nor anergic, “autoimmune” not allergic	148
ILC2s—Bipartisan politicians in cancer	132
Antibody-mediated immunity against lung cancer goes retro	126
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	125
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins	124
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24	124

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models	123
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	122
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	121
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	115
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	112
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	108
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	107
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ	107
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	107
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	107
DuraBle tolerance to CNS antigens	104
Tissue origin and virus specificity shape human CD8 + T cell cytotoxicity	98
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	96
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4 +	95
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	94
RNA exosome drives early B cell development via noncoding RNA processing mechanisms	94
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	93
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	93
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	91
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	89
Immune determinants of chronic sequelae after respiratory viral infection	88
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	87
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	86
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells	85
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge	84
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance	83
Dynamic STING repression orchestrates immune cell development and function	82
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	81
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	81
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	81
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity	80
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	79
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation	76
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8 + T cells lacking a gut-homing phenotype	75
Gutsy memory T cells stand their ground against pathogens	74
Tissue-specific nonheritable influences drive endometrial immune system variation	73
CAR keys to unlock the intracellular immunopeptidome	73
Androgen effects cause sex-biased impairment of CD8 + T cell antitumor activity	73
Unearthing the Rosetta Stone of public antibody responses	70
Early human lung immune cell development and its role in epithelial cell fate	68
Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation	68
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	67
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system	67
Effective CD4 T cell priming requires repertoire scanning by CD301b + migratory cDC2 cells upon lymph node entry	66
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	66
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	66
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function	66
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	65
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	65
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	64

IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells	64
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	63
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	63
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	63
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	63
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	62
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors	62
Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	61
Immune signatures underlying post-acute COVID-19 lung sequelae	61
Functional differences between rodent and human PD-1 linked to evolutionary divergence	60
Platelets and mast cells say “HIAA” to welcome in neutrophils	60
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	60
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	59
Histone demethylation tones down leukemia through innate immunity	59
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes	58
An e-Xist-ential two-edged sword for women	58
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	57
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. Lucas	57
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer	56
EBVerified TCRs and multiple sclerosis	56
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	55
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage	55
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	55
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	55
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine	55
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	54
Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization	54
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease	54
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	54
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	54
Transforming growth factor–β1 in regulatory T cell biology	53
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	53
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	53
GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation	52
Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency	52
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	52
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration	52
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	52
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	52
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	51
Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology	51
Finding TB vaccine antigens: follow the TCRs	51
FOXP3 exon 2 controls T reg stability and autoimmunity	51
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	51
Immune signature clues are key to unlocking the mystery of clinical responses	50
Targeting TLR4 during vaccination boosts MAdCAM-1 + lymphoid stromal cell activation and promotes the aged germinal center response	50
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability	50
A SPARC-ling link to inflammaging	50
The circadian immune system	50
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	49
Plasmablasts from the past: Nostalgic B cells can’t let go	49
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells	49
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	48
Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis	48
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	48
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	48
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells	47
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity	47
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	46
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	46
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	46
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	46
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	46
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	46
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	46
The gene regulatory basis of bystander activation in CD8 + T cells	46
LXR signaling controls homeostatic dendritic cell maturation	46
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	45
TCRward personalized transplant therapies	45
Mitochondria—More than just ATP for CTLs	44
Only pregnant moms can do it….	44
The 10 commandments of immunoregulation in lymphoma	44
How dengue defies dogma: An extrafollicular tale	44
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B	44
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	43
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	43
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	43
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	43
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	43
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	42

Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	42
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	42
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages	41
Brain sensing of metabolic state regulates circulating monocytes	41
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	41
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	41
Nuclear polarization to the immune synapse facilitates an early transcriptional burst	41
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	40
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	40
GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures	40
See no allergen, hear no allergen, speak no allergen!	40
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	40
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	40
CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury	40
Usp22 is an intracellular regulator of systemic emergency hematopoiesis	39
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	39
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation	39
NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation	39
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development	39
NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages	39
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients	38
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells	38
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles	38
DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements	38
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	38
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	38
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine	38
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection	38
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	37
A new tolerogenic cell RORs onto the scene	37
Zfp281 and Zfp148 control CD4 + T cell thymic development and T H 2 functions	37
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	37
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory	37
CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy	37
IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2	37
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models	37
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates	37
Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential	36
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity	36
Recall of B cell memory depends on relative locations of prime and boost immunization	36
Made to order tuft cells by an OCA-T1 isoform switch	36
Size-dependent activation of CAR-T cells	36
Bile acid–sensitive tuft cells regulate biliary neutrophil influx	35
Fishing with autoantibodies nets a gut bacteria that drives arthritis	35
Human T follicular helper clones seed the germinal center–resident regulatory pool	35
Tricky Ts play possum to propagate autoimmune disease	35
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis	35
Move over NAIP, DDX17 diversifies the NLRC4 inflammasome	35
Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner	35
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis	34
Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity	34
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury	34
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf	34
CD19 CAR antigen engagement mechanisms and affinity tuning	34
An engineered viral protein activates STAT5 to prevent T cell suppression	34
Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosis	34
Asparagine availability controls germinal center B cell homeostasis	34
A central role for STAT5 in the transcriptional programing of T helper cell metabolism	34
“ILC2 it, but I can’t promise anything”	33
IL-10mpting T H 17 cell fate in the gut	33
PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells	33
Not just “leuko” after all: Epithelial leukotriene production in type 2 immunity	32
Immuno-amnesia: Without B cells, T cells cannot remember	31
“Training immunity” against nosocomial pathogens	31
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes	31
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy	31
Human life within a narrow range: The lethal ups and downs of type I interferons	31
B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling	31
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 + T cell formation	30
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	30
Age-associated CD4 + T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity	30
Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy	30
A dynamic atlas of immunocyte migration from the gut	30
Selfish antibodies target auto-antigens in cancer	29
Gut bacteria–derived serotonin promotes immune tolerance in early life	29
Promoting (and targeting) alternative expression	29
Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation	29
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	28
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	28
SNIPR alert! Making T cells more precise killers	28
CAR-ving away OX40L with engineered T regs	28
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	28
TB or not TB: That depends on the antibody Fc	27
The cold truth about TCR structure	27
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	27
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	27
Bearing a grudge—How human natural killer cells remember past insults	27
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12	26
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	26
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	26
CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy	26
Metabolic challenges and interventions in CAR T cell therapy	26
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	26
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells	26
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	26