Science Immunology

Article	Citations
RORγt-lineage APCs: The Aire apparent	412
Characterization of the mammalian prodefinitive angio-hematopoietic lineage	392
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	304
Is one lymphocyte’s brake another lymphocyte’s gas?	285
The HLA advantage: Why COVID-19 benched you but not your co-worker	249
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	225
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	210
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	208
Intratumoral immunotherapy relies on B and T cell collaboration	207
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	206
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	194
Operation Nasal Vaccine—Lightning speed to counter COVID-19	190
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	181
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	166
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity	165
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	160
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	157
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	153
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	139
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	127
Neither naïve nor anergic, “autoimmune” not allergic	126
ILC2s—Bipartisan politicians in cancer	126
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins	125
Antibody-mediated immunity against lung cancer goes retro	125
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	123

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models	122
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	119
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	117
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	117
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	113
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	111
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ	109
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	109
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	107
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24	100
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	98
Tissue origin and virus specificity shape human CD8 + T cell cytotoxicity	98
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4 +	95
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	95
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	94
Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life	93
RNA exosome drives early B cell development via noncoding RNA processing mechanisms	93
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	92
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	89
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	89
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge	88
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	87
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	85
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation	83
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance	83
Dynamic STING repression orchestrates immune cell development and function	83
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	82
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	82
Immune determinants of chronic sequelae after respiratory viral infection	81
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity	81
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	80
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	79
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	76
Gutsy memory T cells stand their ground against pathogens	74
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	72
CAR keys to unlock the intracellular immunopeptidome	72
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function	71
Early human lung immune cell development and its role in epithelial cell fate	71
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	71
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	70
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	69
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	69
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	68
Tissue-specific nonheritable influences drive endometrial immune system variation	68
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system	67
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	67
Androgen effects cause sex-biased impairment of CD8 + T cell antitumor activity	67
IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells	67
Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	67
Unearthing the Rosetta Stone of public antibody responses	67

Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	67
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	65
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	64
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8 + T cells lacking a gut-homing phenotype	64
Functional differences between rodent and human PD-1 linked to evolutionary divergence	63
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors	63
Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation	63
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	62
Effective CD4 T cell priming requires repertoire scanning by CD301b + migratory cDC2 cells upon lymph node entry	62
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	62
Histone demethylation tones down leukemia through innate immunity	61
Platelets and mast cells say “HIAA” to welcome in neutrophils	61
An e-Xist-ential two-edged sword for women	60
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	58
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. Lucas	58
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	58
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	58
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine	57
EBVerified TCRs and multiple sclerosis	57
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	57
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	57
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	57
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer	56
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	56
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage	56
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes	56
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	56
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	55
Transforming growth factor–β1 in regulatory T cell biology	55
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	55
Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization	55
Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology	54
GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation	53
The circadian immune system	53
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	52
Targeting TLR4 during vaccination boosts MAdCAM-1 + lymphoid stromal cell activation and promotes the aged germinal center response	52
FOXP3 exon 2 controls T reg stability and autoimmunity	52
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration	52
Finding TB vaccine antigens: follow the TCRs	51
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	51
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability	51
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	51
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	51
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	51
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells	50
A SPARC-ling link to inflammaging	50
Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis	50
Immune signature clues are key to unlocking the mystery of clinical responses	50
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	50
Plasmablasts from the past: Nostalgic B cells can’t let go	50
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	49
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	49
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	49
B cells and dengue: A cat-and-mouse game	49
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	49
The gene regulatory basis of bystander activation in CD8 + T cells	48
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	48
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	48
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	47
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	47
LXR signaling controls homeostatic dendritic cell maturation	47
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	46
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	46
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	46
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	46
TCRward personalized transplant therapies	46
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	45
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B	45
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model	45
Only pregnant moms can do it….	45
The 10 commandments of immunoregulation in lymphoma	45
How dengue defies dogma: An extrafollicular tale	45
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	44
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	44
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages	44
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	43
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	43
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	43
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	43
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	43

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	42
See no allergen, hear no allergen, speak no allergen!	42
Nuclear polarization to the immune synapse facilitates an early transcriptional burst	42
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	42
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	42
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	41
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	41
GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures	41
NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation	41
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes	40
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	40
Usp22 is an intracellular regulator of systemic emergency hematopoiesis	40
CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury	40
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development	40
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	40
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	40
NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages	40
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles	39
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates	39
A new tolerogenic cell RORs onto the scene	39
DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements	39
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients	39
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	39
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection	39
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine	39
Brain sensing of metabolic state regulates circulating monocytes	39
Zfp281 and Zfp148 control CD4 + T cell thymic development and T H 2 functions	38
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory	38
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells	38
B cells targeting parasites capture spatially linked antigens to secure T cell help	38
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models	38
Recall of B cell memory depends on relative locations of prime and boost immunization	38
Made to order tuft cells by an OCA-T1 isoform switch	37
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	37
IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2	37
Size-dependent activation of CAR-T cells	37
CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy	37
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity	37
Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential	37
Tricky Ts play possum to propagate autoimmune disease	36
Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner	36
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury	35
Fishing with autoantibodies nets a gut bacteria that drives arthritis	35
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis	35
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis	35
Move over NAIP, DDX17 diversifies the NLRC4 inflammasome	35
A central role for STAT5 in the transcriptional programing of T helper cell metabolism	34
Human T follicular helper clones seed the germinal center–resident regulatory pool	34
Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosis	34
CD19 CAR antigen engagement mechanisms and affinity tuning	34
Bile acid–sensitive tuft cells regulate biliary neutrophil influx	33
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf	33
An engineered viral protein activates STAT5 to prevent T cell suppression	33
Asparagine availability controls germinal center B cell homeostasis	33
Not just “leuko” after all: Epithelial leukotriene production in type 2 immunity	32
“ILC2 it, but I can’t promise anything”	32
Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy	32
IL-10mpting T H 17 cell fate in the gut	32
Immuno-amnesia: Without B cells, T cells cannot remember	31
“Training immunity” against nosocomial pathogens	31
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	31
B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling	31
Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity	31
Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation	31
Human life within a narrow range: The lethal ups and downs of type I interferons	31
A dynamic atlas of immunocyte migration from the gut	31
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes	30
Age-associated CD4 + T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity	30
PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells	30
Gut bacteria–derived serotonin promotes immune tolerance in early life	29
CAR-ving away OX40L with engineered T regs	29
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 + T cell formation	29
Promoting (and targeting) alternative expression	29
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy	29
Selfish antibodies target auto-antigens in cancer	29
SNIPR alert! Making T cells more precise killers	28
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	28
The cold truth about TCR structure	28
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	27
Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα	27
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	27
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	27
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells	27
Bearing a grudge—How human natural killer cells remember past insults	27
Cis interactions between CD2 and its ligands on T cells are required for T cell activation	27
MTHFD2, metabolic mastermind of CD4 + T cell destiny	27
TB or not TB: That depends on the antibody Fc	27
CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy	26
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	26
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	26
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	26
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma	26
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	26
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity	26
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages	26