Science Immunology

Article	Citations
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	472
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	387
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	375
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	343
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	278
The HLA advantage: Why COVID-19 benched you but not your co-worker	272
RORγt-lineage APCs: The Aire apparent	253
Operation Nasal Vaccine—Lightning speed to counter COVID-19	206
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity	199
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	198
Is one lymphocyte’s brake another lymphocyte’s gas?	193
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation	192
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	191
Intratumoral immunotherapy relies on B and T cell collaboration	190
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	190
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	185
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	175
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	174
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	157
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	154
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	151
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	151
Neither naïve nor anergic, “autoimmune” not allergic	149
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	149
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	136

Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	136
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24	135
ILC2s—Bipartisan politicians in cancer	121
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	121
Antibody-mediated immunity against lung cancer goes retro	120
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	118
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	115
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ	113
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	113
Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis	112
DuraBle tolerance to CNS antigens	109
Immune determinants of chronic sequelae after respiratory viral infection	107
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	106
Dynamic STING repression orchestrates immune cell development and function	104
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge	102
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance	102
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	100
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	99
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	90
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4 +	88
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells	86
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	86
RNA exosome drives early B cell development via noncoding RNA processing mechanisms	85
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	84
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	83
Single-cell analysis pinpoints distinct populations of cytotoxic CD4 + T cells and an IL-10 + CD109 +	83
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	82
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	81
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	80
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	79
SLAMF7 engagement superactivates macrophages in acute and chronic inflammation	79
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	78
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity	78
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors	78
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function	76
Tissue-specific nonheritable influences drive endometrial immune system variation	76
CAR keys to unlock the intracellular immunopeptidome	76
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	75
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	74
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	73
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	72
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	72
Unearthing the Rosetta Stone of public antibody responses	71
Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation	70
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19	68
Androgen effects cause sex-biased impairment of CD8 + T cell antitumor activity	68
IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells	66
Gutsy memory T cells stand their ground against pathogens	65
Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	64
Immune signatures underlying post-acute COVID-19 lung sequelae	64

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	64
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8 + T cells lacking a gut-homing phenotype	64
Effective CD4 T cell priming requires repertoire scanning by CD301b + migratory cDC2 cells upon lymph node entry	63
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	63
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	63
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	63
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	62
Early human lung immune cell development and its role in epithelial cell fate	62
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	62
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	61
Functional differences between rodent and human PD-1 linked to evolutionary divergence	61
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	61
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	59
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	59
Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization	59
Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage	57
Histone demethylation tones down leukemia through innate immunity	57
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	57
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	55
An e-Xist-ential two-edged sword for women	55
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease	55
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes	55
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. Lucas	54
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	53
EBVerified TCRs and multiple sclerosis	52
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	52
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	52
Platelets and mast cells say “HIAA” to welcome in neutrophils	52
Transforming growth factor–β1 in regulatory T cell biology	51
Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology	50
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	50
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	50
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	50
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration	49
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	49
Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β–converting enzyme	49
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability	49
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	49
c-MAF–dependent perivascular macrophages regulate diet-induced metabolic syndrome	49
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	48
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19	48
Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency	48
Finding TB vaccine antigens: follow the TCRs	48
FOXP3 exon 2 controls T reg stability and autoimmunity	48
The circadian immune system	48
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection	47
Targeting TLR4 during vaccination boosts MAdCAM-1 + lymphoid stromal cell activation and promotes the aged germinal center response	47
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	47
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	47
Plasmablasts from the past: Nostalgic B cells can’t let go	47
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	47
A SPARC-ling link to inflammaging	46
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells	46
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	46
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	46
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	45
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	45
Welcoming c-MAF to the macrophage transcription factor VAM-ily	45
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	45
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	44
Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory	44
T regs and inflammation—bring it on!	44
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	44
Immune signature clues are key to unlocking the mystery of clinical responses	43
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	43
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity	43
LXR signaling controls homeostatic dendritic cell maturation	43
The gene regulatory basis of bystander activation in CD8 + T cells	43
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	43
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	42
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	42
How dengue defies dogma: An extrafollicular tale	42
TCRward personalized transplant therapies	41
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages	41
Mitochondria—More than just ATP for CTLs	41
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	41
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	41
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	41
The 10 commandments of immunoregulation in lymphoma	40
Only pregnant moms can do it….	40

BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	40
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	40
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	40
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	40
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	40
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	39
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B	39
GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures	39
CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury	39
See no allergen, hear no allergen, speak no allergen!	39
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	39
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	38
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	38
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development	38
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	38
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	38
Brain sensing of metabolic state regulates circulating monocytes	38
NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation	38
NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages	38
Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis	38
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection	38
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients	37
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles	37
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	37
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation	37
Usp22 is an intracellular regulator of systemic emergency hematopoiesis	37
Size-dependent activation of CAR-T cells	37
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	37
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates	36
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine	36
IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2	36
A new tolerogenic cell RORs onto the scene	36
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	36
Recall of B cell memory depends on relative locations of prime and boost immunization	36
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models	36
Salmonella Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses	36
Zfp281 and Zfp148 control CD4 + T cell thymic development and T H 2 functions	35
The innate power of PD-1 blockade	35
CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy	35
Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential	35
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory	35
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	35
Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner	34
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells	34
Human T follicular helper clones seed the germinal center–resident regulatory pool	34
Fishing with autoantibodies nets a gut bacteria that drives arthritis	34
Move over NAIP, DDX17 diversifies the NLRC4 inflammasome	34
Bile acid–sensitive tuft cells regulate biliary neutrophil influx	34
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes	33
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury	33
An engineered viral protein activates STAT5 to prevent T cell suppression	33
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity	33
A central role for STAT5 in the transcriptional programing of T helper cell metabolism	33
Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosis	33
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis	33
Made to order tuft cells by an OCA-T1 isoform switch	33
Asparagine availability controls germinal center B cell homeostasis	33
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf	33
Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue	33
Tricky Ts play possum to propagate autoimmune disease	33
CD19 CAR antigen engagement mechanisms and affinity tuning	33
A dynamic atlas of immunocyte migration from the gut	32
B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling	32
Immuno-amnesia: Without B cells, T cells cannot remember	32
“Training immunity” against nosocomial pathogens	32
Not just “leuko” after all: Epithelial leukotriene production in type 2 immunity	31
IL-10mpting T H 17 cell fate in the gut	31
Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy	30
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy	30
Gain-of-function IKZF1 variants in humans cause immune dysregulation associated with abnormal T/B cell late differentiation	30
“ILC2 it, but I can’t promise anything”	30
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 + T cell formation	30
Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity	30
PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells	30
Age-associated CD4 + T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity	30
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	29
Gut bacteria–derived serotonin promotes immune tolerance in early life	29
Human life within a narrow range: The lethal ups and downs of type I interferons	28
Selfish antibodies target auto-antigens in cancer	28
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	28
TB or not TB: That depends on the antibody Fc	28
Promoting (and targeting) alternative expression	28
CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy	28
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	28
Metabolic challenges and interventions in CAR T cell therapy	28
SNIPR alert! Making T cells more precise killers	28
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	27
MTHFD2, metabolic mastermind of CD4 + T cell destiny	27
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	27
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	27
CAR-ving away OX40L with engineered T regs	27
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	27
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	27
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	27
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells	27