OOIR: Observatory of International Research

Papers

(The H4-Index of Science Immunology is 80. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome	771
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes	770
The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients	724
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19	642
Comprehensive mapping of immune perturbations associated with severe COVID-19	642
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients	620
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination	515
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients	503
SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients	449
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome	389
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths	337
Natural killer cell immunotypes related to COVID-19 disease severity	324
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients	322
Inhibition of Bruton tyrosine kinase in patients with severe COVID-19	285
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19	253
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence	236
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients	224
SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection	223
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants	220
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19	184
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 ⁺ T cell activation in COVID-19 patients	179
Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 ⁺ T cells	175
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	170
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles	170
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	165

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection	158
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19	158
Prolonged evolution of the human B cell response to SARS-CoV-2 infection	152
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics	146
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis	145
SARS-CoV-2 infection generates tissue-localized immunological memory in humans	144
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes	143
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection	140
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation	136
Human inborn errors of immunity: An expanding universe	136
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 ⁺ T cell responses	135
Gut microbiota–specific IgA ⁺ B cells traffic to the CNS in active multiple sclerosis	133
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses	131
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19	131
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2	131
MAIT cell activation and dynamics associated with COVID-19 disease severity	131
A reservoir of stem-like CD8 ⁺ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response	128
Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward	126
TOX is expressed by exhausted and polyfunctional human effector memory CD8 ⁺ T cells	125
Pharmacological activation of STING blocks SARS-CoV-2 infection	125
Clonal expansion and activation of tissue-resident memory-like T _H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19	124
Early precursors and molecular determinants of tissue-resident memory CD8 ⁺ T lymphocytes revealed by single-cell RNA sequencing	121
The known unknowns of T cell immunity to COVID-19	120
CD8 ⁺ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19	116
Tissue-resident CD4 ⁺ T helper cells assist the development of protective respiratory B and CD8 ⁺ T cell memory responses	114
SARS-CoV-2 seroprevalence among parturient women in Philadelphia	110
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19	108
Bispecific antibodies targeting mutant RAS neoantigens	106
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity	105
Innate immunological pathways in COVID-19 pathogenesis	104
Polyclonal expansion of TCR Vβ 21.3 ⁺ CD4 ⁺ and CD8 ⁺ T cells is a hallmark of multisystem infl	104
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma	102
Immune signatures underlying post-acute COVID-19 lung sequelae	101
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation	101
Human dendritic cells in cancer	100
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy	99
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection	98
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair	98
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	93
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity	89
3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates	89
T cell factor 1: A master regulator of the T cell response in disease	88
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	87
T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection	87
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer	87
Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation	86
SARS-CoV-2 Omicron-neutralizing memory B cells are elicited by two doses of BNT162b2 mRNA vaccine	86
Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes	86
Understanding T cell responses to COVID-19 is essential for informing public health strategies	86
Contribution of resident and circulating precursors to tumor-infiltrating CD8 ⁺ T cell populations in lung cancer	85

T resident helper cells promote humoral responses in the lung	83
HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19	83
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation	82
The expansion of human T-bet ^high CD21 ^low B cells is T cell dependent	81
COVID-19 vaccine side effects: The positives about feeling bad	81