Epilepsia Open

Article	Citations
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint tra	91
Total posterior quadrant disconnection for drug‐resistant epilepsy in children	83
An interview with Ifrah Zawar, 2023 Epilepsia Open prize winner for clinical research	68
Epilepsy following neonatal encephalopathy—Future directions	48
Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system	40
Characterization of low‐grade epilepsy‐associated tumor from implanted stereoelectroencephalography electrodes	39
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients	38
Risk of COVID‐19 infection and seizure exacerbation among patients with epilepsy during the peak of Omicron wave	37
Incorporation bias in clinical prediction models for epilepsy	35
Sudden unexpected death in epilepsy ( SUDEP ): Risk management of pediatric patients with epilepsy	34
Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy	32
One‐year seizure freedom and quality of life in patients with drug‐resistant epilepsy receiving adjunctive vagus nerve stimulation in Japan	30
A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES ‐481 in drug‐resistant epilepsy	30
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy	29
Key steps and barriers in the journey of patients with epilepsy through the National Healthcare System in Spain: The EPIPASS qualitative study	29
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy	28
Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches	28
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life	28
Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States	28
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis	27
Astrocyte subtype‐specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy	26
Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy	25
Deficiency of nNOS in adult‐born dentate granule cells causes epilepsy	25
Neonatal seizures: Advances in diagnosis and management	25
Ex‐SPECTing success: Predictors of successful SPECT radiotracer injection during presurgical video‐EEG admissions	25

Thank you to our reviewers of 2023	25
Efficacy and Safety of adjunctive Perampanel in a prospective, real‐world, Phase IV study in Indian patients aged ≥12 years for Treatment of focal‐onset Epilepsy: Study 508	25
A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3WG2 Neuropathology Working Group o	24
Integration of interictal EEG source localization in presurgical epilepsy evaluation – A single‐center prospective study	24
Gingival enlargement following levetiracetam treatment: A clinical case analysis	24
Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature	24
Late‐onset epilepsy of unknown etiology is more treatment‐responsive than acquired lesional late‐onset epilepsy	23
A multicenter, video‐ EEG ‐based validation of a multimodal wearable device for focal seizure detection in adults: The Seize	22
Sleep architecture in drug‐naïve adult patients with epilepsy: Comparison between focal and generalized epilepsy	22
Outcomes of resective surgery in pediatric patients with drug‐resistant epilepsy: A single‐center study from the Eastern Mediterranean Region	22
Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach	22
Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT	21
Real‐world outcomes of responsive neurostimulation in patients with Lennox–Gastaut syndrome: A multicenter retrospective study	21
Progressive myoclonus epilepsy in Down syndrome with Alzheimer's disease: An 11‐year longitudinal study and proposed diagnostic red flags	21
Epilepsia Open—June 2023—Announcements	20
Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy	20
MonoPER study: Effectiveness and tolerability of PERampanel in monotherapy in real‐world after 12 months of treatment	20
Correction to “Telemedicine in epilepsy care: A Nationwide survey by the Italian Chapter of the International League Against Epilepsy ( LICE ) on ado	20
Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy	20
Letter on: 3D figure of epilepsy syndromes	19
Epilepsy surgery in early infancy: A retrospective, multicenter study	19
Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia	19
Hypophosphatemia in suspected seizures evaluated in first seizure clinics and neurology consults	19
An interview with Ondřej Strýček, 2025 Epilepsia Open prize winner for clinical research	19
Reflections on the first 8 years of Epilepsia Open	18
Abnormal functional connectivity patterns in temporal lobe epilepsy—An international ENIGMA ‐epilepsy study	18
User involvement in the design and development of medical devices in epilepsy: A systematic review	18
Intravenous lacosamide for acute repetitive seizures and convulsive status epilepticus in critically ill children	18
Using stereo‐electroencephalography data to model the optimal intracranial venous sinus location for an endovascular seizure detection device: A feasibility study	18
Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery	18
Discovery ofE2730, a novel selective uncompetitiveGAT1inhibitor, as a candidate for anti‐seizure medication	18
Beliefs, misconceptions, and practices related to epilepsy among adults in Sudan: A large‐scale cross‐sectional study	18
A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analy	18
Interrater reliability of interictal EEG waveforms in Lennox–Gastaut Syndrome	18
Cost‐effectiveness of fenfluramine as add‐on treatment in the management of Dravet Syndrome: A real‐world multicenter study	17
Emotional experience elicited by direct electrical stimulation: Case series and literature review	17
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy	17
Longitudinal EpiTrack assessment of executive functions following vagus nerve stimulation therapy in patients with drug‐resistant epilepsy	17
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms	16
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Epilepsia Open—December 2022—Announcements	16
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Correspondence: FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in silico study	15
Thank you to our reviewers of 2024	15
Epilepsia Open – April 2025 Announcements	15
Epilepsia Open: Welcome to the inaugural lived experience editor and editorial interns	15
Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations	14
Postmortem MRI reveals distinct structural features in sudden unexpected death in epilepsy	14
Status of epilepsy in the tropics: An overlooked perspective	14
Safety and efficacy of rapid withdrawal of antiseizure medications during long‐term video‐electroencephalogram monitoring in children with drug‐resistant epilepsy: A retrospective study	14

Treatment with brivaracetam has no apparent long‐term effects on body weight in pediatric patients with epilepsy	14
Response: Safety and adverse events following COVID‐19 vaccination among people with epilepsy: Correspondence	14
Thank you to the outgoing Editor in Chief of Epilepsia Open, Aristea Galanopoulou	14
Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology	14
Long‐term outcomes of corpus callosotomy in adult patients with drug‐resistant epilepsy: Results from a single neurosurgical center in Mexico	14
Response: Rethinking GABAergic therapy in neonatal seizures: Beyond Scylla and Charybdis	13
Predictive value of traditional laboratory parameters and inflammatory indices for same‐day seizure recurrence in patients with epileptic seizures	13
Epilepsy is an important feature of KBG syndrome associated with poorer developmental outcome	13
The cenobamate KORK study—A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add	13
Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy	13
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real‐world study	13
Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures	13
Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study	12
An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms	12
Chemical analysis and concentrations of cannabidiol substances used for refractory epilepsy in Chilean patients. An underestimated worldwide risk	12
Microstructure imaging in patients undergoing evaluation for epilepsy surgery or low‐grade glioma: Clinical utility of a novel diffusion MRI method	12
First report of Tunisian patients with CDKL5‐related encephalopathy	12
Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy	12
Communicating a diagnosis of Dravet syndrome to parents/caregivers: An international Delphi consensus	12
Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report	12
Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis	12
Transcranial direct current stimulation treatment reduces, while repetitive transcranial magnetic stimulation treatment increases electroencephalography spike rates with refractory occipital lobe epil	12
Evaluating depression in Indonesian adolescents with epilepsy: Comprehensive validation and reliability assessment of the neurological disorders depression inventory‐epilepsy for youth Indonesian vers	12
Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing	12
Reactive oxygen species in status epilepticus	12
PERPRISE: A prospective non‐interventional study of PERampanel as only adjunctive treatment in patients with PRImary or SEcondarily generalized tonic–clonic	12
An interview with Fabienne Kühne, 2024 Epilepsia Open prize winner for clinical research	11
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures	11
AI‐based localization of the epileptogenic zone using intracranial EEG	11
Long‐term efficacy and safety of cannabidiol in patients with tuberous sclerosis complex: 3‐year results from the cannabidiol expanded access program	11
Anti‐seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta‐analysis	11
An interview with Lyndsey Anderson, 2024 Epilepsia Open prize winner for basic science research	11
Effectiveness of add‐on acetazolamide in children with drug‐resistant CHD2‐related epilepsy and in a zebrafish CHD2 model	11
BRIVA‐ONE study: 12‐month outcomes of brivaracetam monotherapy in clinical practice	11
Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi‐center retrospective 12‐year Veterans Health Administration study	11
Issue Information	11
SEEG‐based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure	11
Artificial intelligence in the assessment of epilepsy‐related genetic mutations: Learned from GABA A	11
Utility of repeat stereotactic EEG in pediatric patients with tuberous sclerosis	11
In vitro human cell culture models in a bench‐to‐bedside approach to epilepsy	11
The effect of epilepsy awareness on attitudes toward individuals with epilepsy in Turkish society: A case study from Northern Turkey	11
Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model	10
A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy	10
Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy	10
First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation	10
Characteristics and long‐term outcomes of children with confirmed focal cortical dysplasia type 1 after epilepsy surgery: A population‐based study	10
Feasibility of cardiac‐based seizure detection and prediction: A systematic review of non‐invasive wearable sensor‐based studies	10
Peri‐ictal yawning: A potential lateralizing sign in temporal lobe epilepsy	10
Mendelian randomization reveals no causal relationship between COVID‐19 susceptibility, hospitalization, or severity and epilepsy	10
Epilepsia Open—September 2022—Announcements	10
Impact of hippocampectomy on seizure freedom in temporal encephaloceles: A systematic review and individual participant data meta‐analysis	10
Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism	10
Neuropsychological profile and social cognition in children and adolescents with temporal lobe epilepsy	10
Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1 ‐ mTOR ‐P‐gp axis	10
Medications used for seizure‐emergency management in the UK community: A clinical practice research datalink retrospective database study	10
Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies	10
Cannabidiol for functional seizures (psychogenic nonepileptic seizures/attacks) and other stress‐associated disorders	10
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two‐year prospective surveillance study	10
Evaluation of self‐stigma in patients with epilepsy: Validation of the self‐stigma scale to Spanish (ESSS‐S)	10
Early genetic testing in pediatric epilepsy: Diagnostic and cost implications	10
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate	10
Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome	10
Parsing neuronal circuits involved in comorbidities of epilepsy: A commentary on “Focal impaired awareness seizures in a rodent model: A functional anatomy”	9
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children	9
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates	9
An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European	9
A study of factors influencing self‐stigma in people with epilepsy: A nationwide online questionnaire survey in Japan	9
Issue Information	9
Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention	9
On‐site exposure to clinical epilepsy practice for experimental scientists engaged in epilepsy research: A pilot study by the ILAE commission on neur	9
Issue Information	9
Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy	9
HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study	9
Characterizing electroencephalogram dynamics during sedation withdrawal: Insights into cortical recovery following status epilepticus	9
Febrile status epilepticus and epileptogenesis: The FEBSTAT study	9
Late‐onset asystole associated with vagal nerve stimulation	9
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures	9
Effectiveness of perampanel as the only adjunctive anti‐seizure medication in adults: Final results from the observational PERPRISE study in Germany	9
Multimodal non‐invasive evaluation in MRI‐negative epilepsy patients	9
Factors influencing seizure control of patients with convulsive epilepsy in rural areas of northwest China	9

Epilepsy care pathway: The Finnish model	8
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity	8
Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy	8
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents ( AMPA	8
Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition	8
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials	8
Semiology in spontaneous versus cortical stimulation‐induced seizures during SEEG : A within‐patient comparison study	8
Creativity and its link to epilepsy	8
Neurologists' perspectives on SUDEP communication: A comparative study across five European countries	8
Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem	8
Characterizing the burden of healthcare utilization and expenditure for epilepsy and unclassified seizures in the U.S., 2016–2022	8
Comparison of magnetic resonance‐guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single‐center retrospective cohort study	8
Evaluating the impact of an AI‐powered chatbot on epilepsy education and stigma reduction: A pre‐post intervention study using EpiloBot	8
Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing	8
Long‐term outcomes after NORSE: Treatment with vagus nerve stimulation	8
Global, regional and national burden of epilepsy in adolescents aged 10–19 years from 1990 to 2021: An analysis for the Global Burden of Disease Study 2021	8
Epilepsia Open—December 2024 announcements	8
Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)‐related epilepsy and seizure outcome with different treatment options	8
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study	8
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low‐dose kainic acid systemic injection paradigm in mice	8
Complete lesion resection and early surgical intervention are favorable factors for long‐term seizure freedom in drug‐resistant epileptic spasms	8
Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study	8
Antiseizure medication withdrawal risk estimation and recommendations: A survey of American Academy of Neurology and EpiCARE members	8
Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review	8
Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte‐mediated etiology of epileptic cortical thinning	8
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta‐analysis	8
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The diagnostic value of ictal SPECT—A retrospective, semiquantitative monocenter study	8
The mechanism of mitochondrial autophagy regulating Clathrin‐mediated endocytosis in epilepsy	8
Adjunctive acetazolamide for drug‐resistant seizures in SLC6A1 ‐related neurodevelopmental disorder: An exploratory case series	8
NORSE secondary to anti‐GAD65 antibody‐positive encephalitis treated with novel adjunctive rapid titration VNS protocol	7
Serum perampanel levels in patients with seizures are not affected by hemodialysis	7
A model‐based cost‐effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome	7
Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study	7
Antiseizure medication choice in diffuse glioma: A single‐center population‐based experience	7
Impact of theCOVID‐19 pandemic on people with epilepsy: Findings from theUSarm of theCOV‐Estudy	7
Clinical phenotype and functional influence of GRIN2A variants in epilepsy‐aphasia syndrome	7
Epilepsy in inmate patients seen in a high complexity reference hospital in Colombia: A cross‐sectional study	7
Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy	7
Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working	7
Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review	7
Attention‐deficit/hyperactivity disorder in children with epilepsy: A systematic review and meta‐analysis of prevalence and risk factors	7
Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy	7
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks)	7
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy	7
General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy	7
Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study	7
Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project	7
The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3	7
Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome	7
Preliminary development and validation of the Indonesian Pediatric Epilepsy Questionnaire (INA‐PEPSI) to determine epilepsy and distinguish focal and generalized epilepsy in infants and children with	7
Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders	7
Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome‐wide association studies	7
Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal	7
Treatment of status epilepticus: Physiology, pharmacology, and future directions	7
Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG	7
Bromodomain‐containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia	7
Dynamics of glucose concentration during the initiation of ketogenic diet treatment in children with refractory epilepsy: Results of continuous glucose monitoring	7
Issue Information	7
The bidirectional role of music effect in epilepsy: Friend or foe?	7
Issue Information	7