Epilepsia Open

Article	Citations
Risk of COVID‐19 infection and seizure exacerbation among patients with epilepsy during the peak of Omicron wave	83
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint tra	78
Microglia and status epilepticus in the immature brain	58
Total posterior quadrant disconnection for drug‐resistant epilepsy in children	46
An interview with Ifrah Zawar, 2023 Epilepsia Open prize winner for clinical research	42
Epilepsy following neonatal encephalopathy—Future directions	38
Sudden unexpected death in epilepsy ( SUDEP ): Risk management of pediatric patients with epilepsy	36
Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy	34
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life	32
Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan	30
One‐year seizure freedom and quality of life in patients with drug‐resistant epilepsy receiving adjunctive vagus nerve stimulation in Japan	29
Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system	29
Incorporation bias in clinical prediction models for epilepsy	27
Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches	27
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy	25
Characterization of low‐grade epilepsy‐associated tumor from implanted stereoelectroencephalography electrodes	25
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients	25
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy	24
Key steps and barriers in the journey of patients with epilepsy through the National Healthcare System in Spain: The EPIPASS qualitative study	24
Efficacy and Safety of adjunctive Perampanel in a prospective, real‐world, Phase IV study in Indian patients aged ≥12 years for Treatment of focal‐onset Epilepsy: Study 508	23
MonoPER study: Effectiveness and tolerability of PERampanel in monotherapy in real‐world after 12 months of treatment	23
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis	23
Ex‐SPECTing success: Predictors of successful SPECT radiotracer injection during presurgical video‐EEG admissions	23
Deficiency of nNOS in adult‐born dentate granule cells causes epilepsy	22
Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature	22

Thank you to our reviewers of 2023	22
A multicenter, video‐ EEG ‐based validation of a multimodal wearable device for focal seizure detection in adults: The Seize	22
Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach	21
Sleep architecture in drug‐naïve adult patients with epilepsy: Comparison between focal and generalized epilepsy	21
Neonatal seizures: Advances in diagnosis and management	21
Outcomes of resective surgery in pediatric patients with drug‐resistant epilepsy: A single‐center study from the Eastern Mediterranean Region	20
A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3WG2 Neuropathology Working Group o	20
Integration of interictal EEG source localization in presurgical epilepsy evaluation – A single‐center prospective study	20
Late‐onset epilepsy of unknown etiology is more treatment‐responsive than acquired lesional late‐onset epilepsy	20
Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy	20
Gingival enlargement following levetiracetam treatment: A clinical case analysis	20
Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT	20
Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy	19
Epilepsia Open—June 2023—Announcements	19
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms	19
Letter on: 3D figure of epilepsy syndromes	19
A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analy	18
Acetazolamide: Old drug, new evidence?	18
Reflections on the first 8 years of Epilepsia Open	18
Cost‐effectiveness of fenfluramine as add‐on treatment in the management of Dravet Syndrome: A real‐world multicenter study	18
Using stereo‐electroencephalography data to model the optimal intracranial venous sinus location for an endovascular seizure detection device: A feasibility study	18
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy	18
An interview with Ondřej Strýček, 2025 Epilepsia Open prize winner for clinical research	18
Emotional experience elicited by direct electrical stimulation: Case series and literature review	17
Abnormal functional connectivity patterns in temporal lobe epilepsy—An international ENIGMA ‐epilepsy study	17
User involvement in the design and development of medical devices in epilepsy: A systematic review	17
Discovery ofE2730, a novel selective uncompetitiveGAT1inhibitor, as a candidate for anti‐seizure medication	17
Interrater reliability of interictal EEG waveforms in Lennox–Gastaut Syndrome	17
Beliefs, misconceptions, and practices related to epilepsy among adults in Sudan: A large‐scale cross‐sectional study	17
Hypophosphatemia in suspected seizures evaluated in first seizure clinics and neurology consults	16
Epilepsy surgery in early infancy: A retrospective, multicenter study	16
Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia	16
Intravenous lacosamide for acute repetitive seizures and convulsive status epilepticus in critically ill children	16
Longitudinal EpiTrack assessment of executive functions following vagus nerve stimulation therapy in patients with drug‐resistant epilepsy	16
Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery	16
Epilepsia Open—December 2022—Announcements	16
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Correspondence: FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in silico study	15
Epilepsia Open – April 2025 Announcements	15
Response: Safety and adverse events following COVID‐19 vaccination among people with epilepsy: Correspondence	15
Thank you to our reviewers of 2024	15
Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations	14
Treatment with brivaracetam has no apparent long‐term effects on body weight in pediatric patients with epilepsy	14
Thank you to the outgoing Editor in Chief of Epilepsia Open, Aristea Galanopoulou	14
Epilepsy is an important feature of KBG syndrome associated with poorer developmental outcome	14
Safety and efficacy of rapid withdrawal of antiseizure medications during long‐term video‐electroencephalogram monitoring in children with drug‐resistant epilepsy: A retrospective study	14
Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures	14
Epilepsia Open: Welcome to the inaugural lived experience editor and editorial interns	14
Status of epilepsy in the tropics: An overlooked perspective	13

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology	13
Long‐term outcomes of corpus callosotomy in adult patients with drug‐resistant epilepsy: Results from a single neurosurgical center in Mexico	13
The cenobamate KORK study—A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add	13
Communicating a diagnosis of Dravet syndrome to parents/caregivers: An international Delphi consensus	13
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real‐world study	12
Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report	12
An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms	12
Predictive value of traditional laboratory parameters and inflammatory indices for same‐day seizure recurrence in patients with epileptic seizures	12
Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy	12
Chemical analysis and concentrations of cannabidiol substances used for refractory epilepsy in Chilean patients. An underestimated worldwide risk	12
First report of Tunisian patients with CDKL5‐related encephalopathy	12
Evaluating depression in Indonesian adolescents with epilepsy: Comprehensive validation and reliability assessment of the neurological disorders depression inventory‐epilepsy for youth Indonesian vers	12
Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing	12
Commentary on “Antiseizure activity by opioid receptor antagonism, new evidence”	12
The effect of epilepsy awareness on attitudes toward individuals with epilepsy in Turkish society: A case study from Northern Turkey	11
PERPRISE: A prospective non‐interventional study of PERampanel as only adjunctive treatment in patients with PRImary or SEcondarily generalized tonic–clonic	11
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two‐year prospective surveillance study	11
An interview with Fabienne Kühne, 2024 Epilepsia Open prize winner for clinical research	11
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures	11
Anti‐seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta‐analysis	11
Long‐term efficacy and safety of cannabidiol in patients with tuberous sclerosis complex: 3‐year results from the cannabidiol expanded access program	11
Transcranial direct current stimulation treatment reduces, while repetitive transcranial magnetic stimulation treatment increases electroencephalography spike rates with refractory occipital lobe epil	11
In vitro human cell culture models in a bench‐to‐bedside approach to epilepsy	11
An interview with Lyndsey Anderson, 2024 Epilepsia Open prize winner for basic science research	11
Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy	11
BRIVA‐ONE study: 12‐month outcomes of brivaracetam monotherapy in clinical practice	11
Microstructure imaging in patients undergoing evaluation for epilepsy surgery or low‐grade glioma: Clinical utility of a novel diffusion MRI method	11
Effectiveness of add‐on acetazolamide in children with drug‐resistant CHD2‐related epilepsy and in a zebrafish CHD2 model	11
Issue Information	11
SEEG‐based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure	11
Reactive oxygen species in status epilepticus	11
Mendelian randomization reveals no causal relationship between COVID‐19 susceptibility, hospitalization, or severity and epilepsy	10
Effectiveness of perampanel as the only adjunctive anti‐seizure medication in adults: Final results from the observational PERPRISE study in Germany	10
Impact of hippocampectomy on seizure freedom in temporal encephaloceles: A systematic review and individual participant data meta‐analysis	10
First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation	10
Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi‐center retrospective 12‐year Veterans Health Administration study	10
Cannabidiol for functional seizures (psychogenic nonepileptic seizures/attacks) and other stress‐associated disorders	10
Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies	10
Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis	10
AI‐based localization of the epileptogenic zone using intracranial EEG	10
Epilepsia Open—September 2022—Announcements	10
Early genetic testing in pediatric epilepsy: Diagnostic and cost implications	10
Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model	10
Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study	10
A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy	10
Characterizing electroencephalogram dynamics during sedation withdrawal: Insights into cortical recovery following status epilepticus	9
Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy	9
Neuropsychological profile and social cognition in children and adolescents with temporal lobe epilepsy	9
Multimodal non‐invasive evaluation in MRI‐negative epilepsy patients	9
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder	9
Feasibility of cardiac‐based seizure detection and prediction: A systematic review of non‐invasive wearable sensor‐based studies	9
An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European	9
Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy	9
Evaluation of self‐stigma in patients with epilepsy: Validation of the self‐stigma scale to Spanish (ESSS‐S)	9
Peri‐ictal yawning: A potential lateralizing sign in temporal lobe epilepsy	9
HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study	9
Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences	9
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate	9
Factors influencing seizure control of patients with convulsive epilepsy in rural areas of northwest China	9
Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism	9
A study of factors influencing self‐stigma in people with epilepsy: A nationwide online questionnaire survey in Japan	9
Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome	9
Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1 ‐ mTOR ‐P‐gp axis	9
Medications used for seizure‐emergency management in the UK community: A clinical practice research datalink retrospective database study	9
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials	8
Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem	8
The mechanism of mitochondrial autophagy regulating Clathrin‐mediated endocytosis in epilepsy	8
Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention	8
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates	8
Issue Information	8
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children	8
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study	8
Epilepsia Open—December 2024 announcements	8
Comparison of magnetic resonance‐guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single‐center retrospective cohort study	8
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity	8
Long‐term outcomes after NORSE: Treatment with vagus nerve stimulation	8
Parsing neuronal circuits involved in comorbidities of epilepsy: A commentary on “Focal impaired awareness seizures in a rodent model: A functional anatomy”	8
Impact of COVID‐19 pandemic on epilepsy care in Japan: A national‐level multicenter retrospective cohort study	8
Neurologists' perspectives on SUDEP communication: A comparative study across five European countries	8
Epilepsy care pathway: The Finnish model	8

Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study	8
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low‐dose kainic acid systemic injection paradigm in mice	8
Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition	8
Febrile status epilepticus and epileptogenesis: The FEBSTAT study	8
Characterizing the burden of healthcare utilization and expenditure for epilepsy and unclassified seizures in the U.S., 2016–2022	8
Late‐onset asystole associated with vagal nerve stimulation	8
Issue Information	8
Semiology in spontaneous versus cortical stimulation‐induced seizures during SEEG : A within‐patient comparison study	8
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures	8
Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte‐mediated etiology of epileptic cortical thinning	8
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Issue Information	7
General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy	7
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents ( AMPA	7
Global, regional and national burden of epilepsy in adolescents aged 10–19 years from 1990 to 2021: An analysis for the Global Burden of Disease Study 2021	7
Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study	7
Evaluating the impact of an AI‐powered chatbot on epilepsy education and stigma reduction: A pre‐post intervention study using EpiloBot	7
Dynamics of glucose concentration during the initiation of ketogenic diet treatment in children with refractory epilepsy: Results of continuous glucose monitoring	7
Preliminary development and validation of the Indonesian Pediatric Epilepsy Questionnaire (INA‐PEPSI) to determine epilepsy and distinguish focal and generalized epilepsy in infants and children with	7
Epilepsy in inmate patients seen in a high complexity reference hospital in Colombia: A cross‐sectional study	7
Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG	7
Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome‐wide association studies	7
Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review	7
Bromodomain‐containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia	7
Antiseizure medication withdrawal risk estimation and recommendations: A survey of American Academy of Neurology and EpiCARE members	7
Adjunctive acetazolamide for drug‐resistant seizures in SLC6A1 ‐related neurodevelopmental disorder: An exploratory case series	7
Clinical phenotype and functional influence of GRIN2A variants in epilepsy‐aphasia syndrome	7
Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)‐related epilepsy and seizure outcome with different treatment options	7
The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3	7
Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing	7
Serum perampanel levels in patients with seizures are not affected by hemodialysis	7
Impact of theCOVID‐19 pandemic on people with epilepsy: Findings from theUSarm of theCOV‐Estudy	7
Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy	7
Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study	7
Creativity and its link to epilepsy	7
The diagnostic value of ictal SPECT—A retrospective, semiquantitative monocenter study	7
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks)	7
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta‐analysis	7
Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project	7
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy	7
Issue Information	6
Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal	6
Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working	6
Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review	6
Antiseizure medication choice in diffuse glioma: A single‐center population‐based experience	6
Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity	6
Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases—Results at 1‐year follow‐up examinations	6
Validity of the MoCA as a cognitive screening tool in epilepsy: Are there implications for global care and research?	6
Epilepsy surgery: From bench to the clinics	6
Review of epilepsy care in the Democratic Republic of the Congo	6
Customized targeted massively parallel sequencing enables the identification of novel pathogenic variants in Tunisian patients with developmental and epileptic encephalopathy	6
Issue Information	6
A model‐based cost‐effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome	6
Attention‐deficit/hyperactivity disorder in children with epilepsy: A systematic review and meta‐analysis of prevalence and risk factors	6
Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy	6
Treatment of status epilepticus: Physiology, pharmacology, and future directions	6
Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome	6
In the fast lane: Receptor trafficking during status epilepticus	6
Transient global amnesia after the right temporal epilepsy surgery: A case report	6
Frequency‐specific network changes in mesial temporal lobe epilepsy: Analysis of chronic and transient dysfunctions in the temporo‐amygdala‐orbitofrontal network using magnetoencephalography	6
A public benchmark for human performance in the detection of focal cortical dysplasia	6
Comparison of the effectiveness, safety and tolerability of Perampanel and Levetiracetam as monotherapy in Chinese patients with focal‐onset seizures: A single‐center, ambispective, open‐label, real‐w	6
Embracing a new chapter at Epilepsia Open: A message from the incoming Editor‐in‐Chief	6
Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures	6
The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia	6
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs	6
The bidirectional role of music effect in epilepsy: Friend or foe?	6
Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders	6
The appearance of scalp high‐frequency oscillations is associated with poor seizure control in pediatric epilepsy patients	6
Perampanel monotherapy in pediatric epilepsy: Emphasizing the need for comprehensive safety evaluation	6
ECG‐based epileptic seizure prediction: Challenges of current data‐driven models	6
Genetic etiologies with a large NGS panel in a monocentric cohort of 1000 patients with pediatric onset epilepsies	6
Correspondence between scalp‐EEG and stereoelectroencephalography seizure‐onset patterns in patients with MRI‐negative drug‐resistant focal epilepsy	6
NORSE secondary to anti‐GAD65 antibody‐positive encephalitis treated with novel adjunctive rapid titration VNS protocol	6
How are they doing as adults? Psychosocial and socioeconomic outcomes 11‐30 years after pediatric epilepsy surgery	6