Epilepsia Open

Article	Citations
Total posterior quadrant disconnection for drug‐resistant epilepsy in children	70
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life	67
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis	60
Evaluation of the International League Against Epilepsy 1981, 1989, and 2017 classifications of seizure semiology and etiology in a population‐based cohort of children and adults with epilepsy	57
Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy	49
One‐year seizure freedom and quality of life in patients with drug‐resistant epilepsy receiving adjunctive vagus nerve stimulation in Japan	45
Clinical characteristics and outcomes after new‐onset seizure among Zambian children with HIV during the antiretroviral therapy era	40
Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches	37
Characterization of low‐grade epilepsy‐associated tumor from implanted stereoelectroencephalography electrodes	31
Key steps and barriers in the journey of patients with epilepsy through the National Healthcare System in Spain: The EPIPASS qualitative study	30
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy	27
Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia”	26
Microglia and status epilepticus in the immature brain	24
An interview with Ifrah Zawar, 2023 Epilepsia Open prize winner for clinical research	23
Epilepsy following neonatal encephalopathy—Future directions	22
Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan	21
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients	21
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy	21
Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy	21
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint tra	20
Risk of COVID‐19 infection and seizure exacerbation among patients with epilepsy during the peak of Omicron wave	20
A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3WG2 Neuropathology Working Group o	19
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges	19
Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system	19
Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT	18

Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy	18
Thank you to our reviewers of 2023	18
Neonatal seizures: Advances in diagnosis and management	18
Ex‐SPECTing success: Predictors of successful SPECT radiotracer injection during presurgical video‐EEG admissions	18
Sleep architecture in drug‐naïve adult patients with epilepsy: Comparison between focal and generalized epilepsy	18
Integration of interictal EEG source localization in presurgical epilepsy evaluation – A single‐center prospective study	18
Efficacy and Safety of adjunctive Perampanel in a prospective, real‐world, Phase IV study in Indian patients aged ≥12 years for Treatment of focal‐onset Epilepsy: Study 508	18
Drug‐resistant epilepsy and the hypothesis of intrinsic severity: What about the high‐frequency oscillations?	18
MonoPER study: Effectiveness and tolerability of PERampanel in monotherapy in real‐world after 12 months of treatment	17
Late‐onset epilepsy of unknown etiology is more treatment‐responsive than acquired lesional late‐onset epilepsy	17
Gingival enlargement following levetiracetam treatment: A clinical case analysis	17
Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach	17
Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy	17
Outcomes of resective surgery in pediatric patients with drug‐resistant epilepsy: A single‐center study from the Eastern Mediterranean Region	16
Epilepsia Open—June 2023—Announcements	16
Deficiency of nNOS in adult‐born dentate granule cells causes epilepsy	16
Letter on: 3D figure of epilepsy syndromes	16
Emotional experience elicited by direct electrical stimulation: Case series and literature review	15
Interrater reliability of interictal EEG waveforms in Lennox–Gastaut Syndrome	15
Beliefs, misconceptions, and practices related to epilepsy among adults in Sudan: A large‐scale cross‐sectional study	15
Longitudinal EpiTrack assessment of executive functions following vagus nerve stimulation therapy in patients with drug‐resistant epilepsy	15
Acetazolamide: Old drug, new evidence?	15
Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia	15
Intravenous lacosamide for acute repetitive seizures and convulsive status epilepticus in critically ill children	14
Reflections on the first 8 years of Epilepsia Open	14
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms	14
Discovery ofE2730, a novel selective uncompetitiveGAT1inhibitor, as a candidate for anti‐seizure medication	14
Using stereo‐electroencephalography data to model the optimal intracranial venous sinus location for an endovascular seizure detection device: A feasibility study	13
Hypophosphatemia in suspected seizures evaluated in first seizure clinics and neurology consults	13
Epilepsy surgery in early infancy: A retrospective, multicenter study	13
A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analy	13
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy	13
Epilepsia Open—December 2022—Announcements	13
User involvement in the design and development of medical devices in epilepsy: A systematic review	13
Experience of perampanel monotherapy beyond initial titration to achieve seizure freedom in patients with focal‐onset seizures with newly diagnosed or currently untreated recurrent epilepsy: A post ho	13
Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery	13
An interview with Ondřej Strýček, 2025 Epilepsia Open prize winner for clinical research	13
Thank you to our reviewers of 2024	12
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Correspondence: FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in silico study	12
Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures	12
Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations	12
Response: Safety and adverse events following COVID‐19 vaccination among people with epilepsy: Correspondence	12
Epilepsia Open: Welcome to the inaugural lived experience editor and editorial interns	12
Safety and efficacy of rapid withdrawal of antiseizure medications during long‐term video‐electroencephalogram monitoring in children with drug‐resistant epilepsy: A retrospective study	12
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Treatment with brivaracetam has no apparent long‐term effects on body weight in pediatric patients with epilepsy	12
Epilepsia Open – April 2025 Announcements	12
Communicating a diagnosis of Dravet syndrome to parents/caregivers: An international Delphi consensus	12
Predictive value of traditional laboratory parameters and inflammatory indices for same‐day seizure recurrence in patients with epileptic seizures	11

Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy	11
Status of epilepsy in the tropics: An overlooked perspective	11
PERPRISE: A prospective non‐interventional study of PERampanel as only adjunctive treatment in patients with PRImary or SEcondarily generalized tonic–clonic	11
Chemical analysis and concentrations of cannabidiol substances used for refractory epilepsy in Chilean patients. An underestimated worldwide risk	11
Epilepsy is an important feature of KBG syndrome associated with poorer developmental outcome	11
Long‐term outcomes of corpus callosotomy in adult patients with drug‐resistant epilepsy: Results from a single neurosurgical center in Mexico	11
Evaluating depression in Indonesian adolescents with epilepsy: Comprehensive validation and reliability assessment of the neurological disorders depression inventory‐epilepsy for youth Indonesian vers	11
Anti‐seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta‐analysis	11
Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report	11
The cenobamate KORK study—A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add	11
Antiseizure medication discovery: Recent and future paradigm shifts	11
Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis	11
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real‐world study	11
Thank you to the outgoing Editor in Chief of Epilepsia Open, Aristea Galanopoulou	11
Reactive oxygen species in status epilepticus	10
Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study	10
Commentary on “Antiseizure activity by opioid receptor antagonism, new evidence”	10
Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy	10
A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy	10
First report of Tunisian patients with CDKL5‐related encephalopathy	10
Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi‐center retrospective 12‐year Veterans Health Administration study	10
An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms	10
First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation	10
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures	10
Transcranial direct current stimulation treatment reduces, while repetitive transcranial magnetic stimulation treatment increases electroencephalography spike rates with refractory occipital lobe epil	10
In vitro human cell culture models in a bench‐to‐bedside approach to epilepsy	10
Impact of hippocampectomy on seizure freedom in temporal encephaloceles: A systematic review and individual participant data meta‐analysis	9
An interview with Lyndsey Anderson, 2024 Epilepsia Open prize winner for basic science research	9
An interview with Fabienne Kühne, 2024 Epilepsia Open prize winner for clinical research	9
AI‐based localization of the epileptogenic zone using intracranial EEG	9
Epilepsia Open—September 2022—Announcements	9
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two‐year prospective surveillance study	9
Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing	9
Issue Information	9
Effectiveness of add‐on acetazolamide in children with drug‐resistant CHD2‐related epilepsy and in a zebrafish CHD2 model	9
BRIVA‐ONE study: 12‐month outcomes of brivaracetam monotherapy in clinical practice	9
Epilepsia Open–December 2021–Announcements	9
Long‐term efficacy and safety of cannabidiol in patients with tuberous sclerosis complex: 3‐year results from the cannabidiol expanded access program	9
The effect of epilepsy awareness on attitudes toward individuals with epilepsy in Turkish society: A case study from Northern Turkey	9
SEEG‐based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure	9
Serotonin receptors in epilepsy: Novel treatment targets?	9
Mendelian randomization reveals no causal relationship between COVID‐19 susceptibility, hospitalization, or severity and epilepsy	8
Medications used for seizure‐emergency management in the UK community: A clinical practice research datalink retrospective database study	8
Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy	8
Effectiveness of perampanel as the only adjunctive anti‐seizure medication in adults: Final results from the observational PERPRISE study in Germany	8
Feasibility of cardiac‐based seizure detection and prediction: A systematic review of non‐invasive wearable sensor‐based studies	8
Early genetic testing in pediatric epilepsy: Diagnostic and cost implications	8
Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences	8
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder	8
Cannabidiol for functional seizures (psychogenic nonepileptic seizures/attacks) and other stress‐associated disorders	8
Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy	8
Evaluation of self‐stigma in patients with epilepsy: Validation of the self‐stigma scale to Spanish (ESSS‐S)	8
Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model	8
A study of factors influencing self‐stigma in people with epilepsy: A nationwide online questionnaire survey in Japan	8
Peri‐ictal yawning: A potential lateralizing sign in temporal lobe epilepsy	8
Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism	8
Thank you to our Reviewers of 2021	8
Factors influencing seizure control of patients with convulsive epilepsy in rural areas of northwest China	8
HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study	8
Multimodal non‐invasive evaluation in MRI‐negative epilepsy patients	8
The effects of COVID‐19 measures on the hospitalization of patients with epilepsy and status epilepticus in Thailand: An interrupted time series analysis	8
Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies	8
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate	7
Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention	7
Issue Information	7
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children	7
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates	7
Characterizing the burden of healthcare utilization and expenditure for epilepsy and unclassified seizures in the U.S., 2016–2022	7
An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European	7
The mechanism of mitochondrial autophagy regulating Clathrin‐mediated endocytosis in epilepsy	7
Epilepsy care pathway: The Finnish model	7
Long‐term outcomes after NORSE: Treatment with vagus nerve stimulation	7
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures	7
Impact of COVID‐19 pandemic on epilepsy care in Japan: A national‐level multicenter retrospective cohort study	7
Parsing neuronal circuits involved in comorbidities of epilepsy: A commentary on “Focal impaired awareness seizures in a rodent model: A functional anatomy”	7
Issue Information	7
Febrile status epilepticus and epileptogenesis: The FEBSTAT study	7
Late‐onset asystole associated with vagal nerve stimulation	7
Ordinal regression increases statistical power to predict epilepsy surgical outcomes	7
Neurologists' perspectives on SUDEP communication: A comparative study across five European countries	7

Factors not considered in the study of drug‐resistant epilepsy: Drug‐resistant epilepsy: Assessment of neuroinflammation	7
Issue Information	6
A retrospective, real‐world experience of perampanel monotherapy in patient with first new onset focal seizure: A Thailand experience	6
Adjunctive acetazolamide for drug‐resistant seizures in SLC6A1 ‐related neurodevelopmental disorder: An exploratory case series	6
Evaluating the impact of an AI‐powered chatbot on epilepsy education and stigma reduction: A pre‐post intervention study using EpiloBot	6
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity	6
Issue Information	6
Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review	6
Epilepsia Open—December 2024 announcements	6
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Creativity and its link to epilepsy	6
Global, regional and national burden of epilepsy in adolescents aged 10–19 years from 1990 to 2021: An analysis for the Global Burden of Disease Study 2021	6
The National Comprehensive Governance for epilepsy prevention and control in China	6
Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)‐related epilepsy and seizure outcome with different treatment options	6
Antiseizure medication withdrawal risk estimation and recommendations: A survey of American Academy of Neurology and EpiCARE members	6
Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition	6
The diagnostic value of ictal SPECT—A retrospective, semiquantitative monocenter study	6
Issue Information	6
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low‐dose kainic acid systemic injection paradigm in mice	6
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials	6
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)	6
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta‐analysis	6
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Prospective multisite cohort study of patient‐reported outcomes in adults with new‐onset seizures	6
Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy	6
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study	6
Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem	6
Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing	6
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Comparison of magnetic resonance‐guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single‐center retrospective cohort study	6
Antiseizure medication choice in diffuse glioma: A single‐center population‐based experience	5
Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal	5
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs	5
Customized targeted massively parallel sequencing enables the identification of novel pathogenic variants in Tunisian patients with developmental and epileptic encephalopathy	5
Embracing a new chapter at Epilepsia Open: A message from the incoming Editor‐in‐Chief	5
Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy	5
Different pharmacoresistance of focal epileptic spasms, generalized epileptic spasms, and generalized epileptic spasms combined with focal seizures	5
Attention‐deficit/hyperactivity disorder in children with epilepsy: A systematic review and meta‐analysis of prevalence and risk factors	5
General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy	5
Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG	5
Issue Information	5
Clinical phenotype and functional influence of GRIN2A variants in epilepsy‐aphasia syndrome	5
Serum perampanel levels in patients with seizures are not affected by hemodialysis	5
Treatment of status epilepticus: Physiology, pharmacology, and future directions	5
Bromodomain‐containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia	5
Correspondence between scalp‐EEG and stereoelectroencephalography seizure‐onset patterns in patients with MRI‐negative drug‐resistant focal epilepsy	5
In the fast lane: Receptor trafficking during status epilepticus	5
Genetic etiologies with a large NGS panel in a monocentric cohort of 1000 patients with pediatric onset epilepsies	5
Review of epilepsy care in the Democratic Republic of the Congo	5
Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome	5
Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study	5
Impact of theCOVID‐19 pandemic on people with epilepsy: Findings from theUSarm of theCOV‐Estudy	5
The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3 pathogenic variants	5
A model‐based cost‐effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome	5
Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome‐wide association studies	5
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks)	5
Epilepsy in inmate patients seen in a high complexity reference hospital in Colombia: A cross‐sectional study	5
Preliminary development and validation of the Indonesian Pediatric Epilepsy Questionnaire (INA‐PEPSI) to determine epilepsy and distinguish focal and generalized epilepsy in infants and children with	5
Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study	5
Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders	5
Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures	5
The appearance of scalp high‐frequency oscillations is associated with poor seizure control in pediatric epilepsy patients	5
The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia	5
Epilepsia Open—March 2022—Announcements	5
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy	5
Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review	5
NORSE secondary to anti‐GAD65 antibody‐positive encephalitis treated with novel adjunctive rapid titration VNS protocol	5
Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working	5
The bidirectional role of music effect in epilepsy: Friend or foe?	5
Dynamics of glucose concentration during the initiation of ketogenic diet treatment in children with refractory epilepsy: Results of continuous glucose monitoring	5
Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project	5