JACC-Basic to Translational Science

Article	Citations
Recognizing Early Career Translational Investigators	119
Reducing Plasma Factor XI Concentration With siRNA Technology	109
CXC-Chemokine-Receptor-Type-5 Expression on Circulating Naive B Cells Predicts Improvement After Cardiac Resynchronization Therapy	94
Unveiling the PGAM5-ANGPTL3 Axis	72
Editorial Board	69
Mitochondrial DNA in Uremia and New Targets to Treat Myocardial Hypertrophy in the Cardiorenal Syndrome	60
New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology	60
Targeting Syntaxin 17 to Improve Mitophagy in Heart Failure	58
Reading a Good Transcript Soothes MYZAPed Heart	56
PD-1 Checkmate and the 2-Edged Sword of the Immune System	54
When Off-Target Is the Target	51
Full Issue PDF	49
Can Vaccination Prevent the Development of Chagas Disease Cardiomyopathy?	48
JACC: Basic to Translational Science 2016-2025	48
Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2 Clonal Hematopoiesis	45
Editorial Board	43
1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model	41
Is it Time to Abandon the Use of P-Values in Early Phase Translational Trials: Why (Effect) Size Matters	40
Interorganellar Ca2+ Flux Assessment by Flow Cytometry Reveals an Altered Mitochondrial Ca2+ Homeostasis in Circulating Lymphocytes of STEMI Patients	40
Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome	40
Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment	40
Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model Induced by Bilateral Pulmonary Vein Banding	39
Is Laser Doppler Perfusion Imaging Truly a “Gold Standard” for Preclinical Peripheral Artery Disease Research?	38
Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability to Cause Aortopathy	38
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress	37

New Drug-Coated Balloons on the Horizon	36
Full Issue PDF	36
Recognizing Early Career Translational Investigators	35
Addressing the Reproducibility Crisis in Science	35
The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression	35
Full Issue PDF	34
Antibody Matrimony in a Duel of Hearts	31
ApoM Activates Autophagy and Suppresses Lyosomal Lethargy to Combat Doxorubicin Cardiomyopathy	31
Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis	31
Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure	31
Is Endogenous Fibrinolysis a Major Player in Occurrence of Atherothrombotic Events Following Acute Myocardial Infarction?	31
SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics	31
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism	30
Systems Biology Identifies TARS2 as a Cardiomyocyte Regulator of Mitochondrial Oxidative Stress in Dilated Cardiomyopathy	29
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms	28
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction	28
Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart	28
Soluble Programmed Death-1 Predicts Clinical Outcome After STEMI	27
Endocardial Fibrosis Elastosis	27
Interferon Interrupted	27
Editorial Board	27
Inhibiting Serotonin to Treat Pulmonary Arterial Hypertension	26
From Risk to Remedy?	26
Phosphoglycerate Mutase 5 Is Important Mediator for Instigating Arterial Lipid Accumulation and Aggravating Atherosclerosis	26
ATP-Citrate Lyase in Heart Failure	26
C-Type Natriuretic Peptide in Essential Hypertension	26
Should All Translational Scientists Be Swifties?	25
A Differentiated Approach Delivering Targeted Thrombectomy for VTE	24
Reply	23
From Colon to Aortic Aneurysm: Trek of the Treg	23
The Farm to Table HFpEF Kitchen	23
Full Issue Pdf	23
Reply	22
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation	22
Lower Extremity Lymphatic Flow/Drainage Assessment by Indocyanine Green Fluorescent Lymphography in Heart Failure Patients	21
A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification	21
Editing the Plaque	21
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation	20
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction	20
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules	20
When Facts Become Forbidden	20
Red Blood Cell-Mediated Cardioprotection Is Impaired in ST-Segment Elevation Myocardial Infarction Patients With Anemia	20
Pulsatile ECMO	20
Fir(e)ing the Rhythm	19
Reply	19
Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications	19
Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling	18
The Impact of Semaglutide on Cardiac Mass and Function Requires Further Investigation	18
The Virtual Patient Simulator	18
CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction	18

Full Issue PDF	18
Proteomics of Large Artery Stiffness	18
Reassessing the Mechanisms of PLN-R14del Cardiomyopathy	17
JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude	17
Full Issue PDF	17
Tissue Engineered Vascular Grafts	17
Full Issue PDF	17
A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes	17
Full Issue Pdf	17
Ticagrelor Antibiotic Effect	16
Full Issue PDF	16
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation	16
Small Molecule Activators of Mitochondrial Fusion Prevent Congenital Heart Defects Induced by Maternal Diabetes	16
GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis	16
Noninvasive Cardiovascular Imaging in Preclinical Research	16
Pulsatile Ventricular Assist Platform	16
Recognizing Early Career Translational Investigators	16
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction	16
Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats	15
IL-6 Inhibitors and TNF Inhibitors	15
Where Comity in Science Goes to Die	15
Full Issue PDF	15
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2	15
Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling	15
Introducing the 2024 Transcatheter Cardiovascular Therapeutics (TCT) Shark Tank Presentations	15
RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction	15
Real-Time Revolution	15
The Past, Present, and Promising Future of Direct Cardiac Compression Devices	15
Reverse Translation of Pericardial Access	15
A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity	14
Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure	14
Quality Over Quantity	14
Synbiotics and Gut-Heart Axis in Cardiometabolic Disease	14
Structural and Functional Adaptations to Exercise Training	14
Editorial Board	14
Experimental Models of Hypertrophic Cardiomyopathy	14
Editorial Board	14
Turn(over) the Page	14
Macrophage Mayhem in Aortic Aneurysm	14
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease	14
Editorial Board	14
Editorial Board	13
Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model	13
GLP-1 Receptor Agonists, the Holy Grail Preventing Atrial Fibrillation in Patients With T2D?	13
JACC: Basic to Translational Science 2024 Thomas Force Young Investigator Award Winner	13
Charting New Real Estate	13
FNDC4 Prevents Aging-Related Cardiac Dysfunction	13
Decoding MTSS1	13
Autonomic Modulation of Atrial Fibrillation	13
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury	12
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease	12
Publisher's Note	12
Full Issue PDF	12
Partial Heart Transplant Growth and Hemodynamic Function in Piglets	12
Recognizing Early Career Translational Investigators	12
TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla	12
Remembering Ada L. Steininger	12
Full Issue PDF	12
BAG3 in the Heart	11
Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm	11
Minimally Invasive Aortic Regurgitation Surgery	11
Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement	11
Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis	11
Effect of Semaglutide on Epicardial Adipogenesis and hiPSC-Atrial Cardiomyocytes New Hope in Targeting Epicardial Adipose Tissue	11
Animal Models in Biomedical Research	11
Atrial Metabolic Stress	11
The Imperative to Enhance Cost-Effectiveness for Cardiovascular Therapeutic Development	10
Editorial Board	10
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload	10
Paradoxical Effect of Caloric Restriction on Overload-Induced Muscle Growth in Diastolic Heart Failure	10
In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections	10
Shielding the Heart	10
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction	10
Unmasking Hormonal Mechanisms of Hypertension in Obesity	10
Is Obesity a Major Driver of Primary Aldosteronism?	10
Myocardial Infarction Platelet Gene Expression Signatures in Women	10
Who Should Be Accountable for Scientific Accountability?	10
The Cardiac Circadian Clock	10
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension	10
Introducing the 2024 THT Shark Tank Edition of JACC: Basic to Translational Science	10

Recognizing Early Career Translational Investigators	10
Inhibition of Factor XI Using RBD4059	10
Tit for TAK1	10
Continuous Monitoring of Blood Pressure and Vascular Hemodynamic Properties With Miniature Extravascular Hall-Based Magnetic Sensor	10
Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation	10
Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1–Deficient Mice	10
New Insights Into the Therapy for Lamin-Associated Dilated Cardiomyopathy	9
Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise	9
Low-Grade Inflammation	9
Editorial Board	9
Editorial Board	9
Full Issue PDF	9
A (Alpha1-Adrenergic Receptors), B (Blocking Alpha1-Adrenergic Receptors), C (Catecholamines)	9
Translating Imaging Into 3D Printed Cardiovascular Phantoms	9
Cardiovascular Disease in Duchenne Muscular Dystrophy	9
Mitophagy Regulators as Novel Targets in Sepsis-Induced Myocardial Dysfunction	9
New Insights in the Pathology of Chronic Thromboembolic Pulmonary Hypertension	9
Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health	9
High Maternal Glycine Levels Increase the Risk of Developing Atrial Septal Defect in the Offspring	9
Controlled Right Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy	9
Full Issue PDF	9
Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids	9
JACC Journals’ Pathway Forward With AI Tools	8
Will Gene Editing Orphanize Rare Diseases?	8
The Antioxidant Vitamin B12 Analogue Cobinamide as a Treatment for Marfan Syndrome	8
The Emerging Role of Circular RNAs in Cardio-Oncology	8
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy	8
Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling	8
Proteome-Wide Genetic Investigation of Large Artery Stiffness	8
Red Blood Cell Transfusion and Cardiac Surgery–Associated Acute Kidney Injury	8
Platelet-Derived Growth Factors	8
PCSK9 Inhibition	8
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction	8
Editorial Board	8
Are 3 Aorta Pumps Better Than 1 Transaortic to Preserve Von Willebrand Factor?	8
Full Issue PDF	8
Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase	8
Mitochondrial Targeted Therapies to Prevent Maternal Diabetes–Induced Congenital Heart Defects	7
Dysregulation of IL-6/MCP-1/STAT3 Axis	7
INKing the Cardiotoxicity Out of Doxorubicin	7
Heart Failure Solutions	7
Associations of Epigenetic Age Acceleration With CVD Risks Across the Lifespan	7
Editorial Board	7
The Pathology of Primary Mitral Regurgitation	7
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury	7
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes	7
A Novel Device for Tricuspid Regurgitation Reduction Featuring 3-Dimensional Leaflet and Atraumatic Anchor	7
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy	7
The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support	7
Editorial Board	7
Clonal Hematopoiesis and Transcatheter Aortic Valve Replacement	7
In Memory of Dr Gary D. Lopaschuk, PhD (1955–2025)	7
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models	7
Deep Image Segmentation for Cardiomyocyte Proliferation	7
Vagus Nerve Stimulation for Myocardial Ischemia	6
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction	6
Exploring Mechanisms of Pulmonary Artery Banding in a Rat Model of Dilated Cardiomyopathy	6
Moving Beyond the Hype in Extracellular Vesicle Therapy	6
Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction	6
OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration	6
HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells	6
Natriuretic Peptides and Metabolic Hypertension	6
Cardiovascular Research in Friedreich Ataxia	6
A New Ex Vivo Model to Study Cardiac Fibrosis in Whole Mouse Hearts	6
Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure	6
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF	6
The Enigmata of Cardioprotection With SGLT2 Inhibition	6
Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis	6