JACC-Basic to Translational Science

Article	Citations
Recognizing Early Career Translational Investigators	126
Reducing Plasma Factor XI Concentration With siRNA Technology	115
CXC-Chemokine-Receptor-Type-5 Expression on Circulating Naive B Cells Predicts Improvement After Cardiac Resynchronization Therapy	105
Unveiling the PGAM5-ANGPTL3 Axis	74
Mitochondrial DNA in Uremia and New Targets to Treat Myocardial Hypertrophy in the Cardiorenal Syndrome	72
New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology	65
Targeting Syntaxin 17 to Improve Mitophagy in Heart Failure	63
Reading a Good Transcript Soothes MYZAPed Heart	62
PD-1 Checkmate and the 2-Edged Sword of the Immune System	59
When Off-Target Is the Target	58
Full Issue PDF	57
Can Vaccination Prevent the Development of Chagas Disease Cardiomyopathy?	54
Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2 Clonal Hematopoiesis	53
Editorial Board	51
1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model	48
Interorganellar Ca2+ Flux Assessment by Flow Cytometry Reveals an Altered Mitochondrial Ca2+ Homeostasis in Circulating Lymphocytes of STEMI Patients	45
Is it Time to Abandon the Use of P-Values in Early Phase Translational Trials: Why (Effect) Size Matters	44
Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability to Cause Aortopathy	43
Is Laser Doppler Perfusion Imaging Truly a “Gold Standard” for Preclinical Peripheral Artery Disease Research?	42
Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy	41
Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment	41
Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model Induced by Bilateral Pulmonary Vein Banding	39
Addressing the Reproducibility Crisis in Science	39
JACC: Basic to Translational Science 2016-2025	39
Full Issue PDF	39

Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome	39
Recognizing Early Career Translational Investigators	38
The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression	37
Is Endogenous Fibrinolysis a Major Player in Occurrence of Atherothrombotic Events Following Acute Myocardial Infarction?	36
Full Issue PDF	36
Antibody Matrimony in a Duel of Hearts	35
ApoM Activates Autophagy and Suppresses Lyosomal Lethargy to Combat Doxorubicin Cardiomyopathy	34
New Drug-Coated Balloons on the Horizon	32
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms	32
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism	32
Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart	32
Systems Biology Identifies TARS2 as a Cardiomyocyte Regulator of Mitochondrial Oxidative Stress in Dilated Cardiomyopathy	31
SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics	30
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction	29
Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure	29
IL-1–Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis	29
Soluble Programmed Death-1 Predicts Clinical Outcome After STEMI	27
Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis	27
Interferon Interrupted	27
Editing the Plaque	27
The Farm to Table HFpEF Kitchen	26
Phosphoglycerate Mutase 5 Is Important Mediator for Instigating Arterial Lipid Accumulation and Aggravating Atherosclerosis	26
A Differentiated Approach Delivering Targeted Thrombectomy for VTE	26
Atrial Fibrillation Beyond the Atrium	26
Should All Translational Scientists Be Swifties?	26
Full Issue Pdf	25
Reply	25
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation	24
When Facts Become Forbidden	24
Pulsatile ECMO	24
From Colon to Aortic Aneurysm: Trek of the Treg	24
Editorial Board	24
Inhibiting Serotonin to Treat Pulmonary Arterial Hypertension	23
Reply	23
Endocardial Fibrosis Elastosis	23
From Risk to Remedy?	23
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction	22
Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling	22
C-Type Natriuretic Peptide in Essential Hypertension	22
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules	21
Reply	21
Red Blood Cell-Mediated Cardioprotection Is Impaired in ST-Segment Elevation Myocardial Infarction Patients With Anemia	21
Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications	20
ATP-Citrate Lyase in Heart Failure	20
Proteomic Signatures of High-Risk Coronary Plaque Features and Incident Events	20
Lower Extremity Lymphatic Flow/Drainage Assessment by Indocyanine Green Fluorescent Lymphography in Heart Failure Patients	20
A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification	19
Proteomics of Large Artery Stiffness	18
CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction	18
Full Issue PDF	18

Full Issue Pdf	18
Fir(e)ing the Rhythm	18
Full Issue PDF	18
JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude	18
The Impact of Semaglutide on Cardiac Mass and Function Requires Further Investigation	18
Full Issue PDF	18
Noninvasive Cardiovascular Imaging in Preclinical Research	18
Full Issue PDF	18
Real-Time Revolution	17
Small Molecule Activators of Mitochondrial Fusion Prevent Congenital Heart Defects Induced by Maternal Diabetes	17
Recognizing Early Career Translational Investigators	17
IL-6 Inhibitors and TNF Inhibitors	17
GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis	17
Ticagrelor Antibiotic Effect	17
Tissue Engineered Vascular Grafts	17
The Past, Present, and Promising Future of Direct Cardiac Compression Devices	17
The Virtual Patient Simulator	17
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation	17
Pulsatile Ventricular Assist Platform	17
A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes	17
RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction	17
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction	16
Reverse Translation of Pericardial Access	16
Where Comity in Science Goes to Die	16
Full Issue PDF	16
Reassessing the Mechanisms of PLN-R14del Cardiomyopathy	16
Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats	16
Introducing the 2024 Transcatheter Cardiovascular Therapeutics (TCT) Shark Tank Presentations	16
Editorial Board	15
Quality Over Quantity	15
Editorial Board	15
Full Issue PDF	15
Synbiotics and Gut-Heart Axis in Cardiometabolic Disease	15
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease	15
Turn(over) the Page	15
Editorial Board	15
TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla	15
Editorial Board	15
Charting New Real Estate	14
Autonomic Modulation of Atrial Fibrillation	14
JACC: Basic to Translational Science 2024 Thomas Force Young Investigator Award Winner	14
Partial Heart Transplant Growth and Hemodynamic Function in Piglets	14
Structural and Functional Adaptations to Exercise Training	14
Decoding MTSS1	14
GLP-1 Receptor Agonists, the Holy Grail Preventing Atrial Fibrillation in Patients With T2D?	14
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease	14
Rheumatic Heart Disease	13
Experimental Models of Hypertrophic Cardiomyopathy	13
Full Issue PDF	13
Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure	13
Macrophage Mayhem in Aortic Aneurysm	13
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury	13
Remembering Ada L. Steininger	13
Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model	13
FNDC4 Prevents Aging-Related Cardiac Dysfunction	13
Recognizing Early Career Translational Investigators	13
Minimally Invasive Aortic Regurgitation Surgery	12
Animal Models in Biomedical Research	12
Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation	12
Continuous Monitoring of Blood Pressure and Vascular Hemodynamic Properties With Miniature Extravascular Hall-Based Magnetic Sensor	12
Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis	12
In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections	12
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload	12
Atrial Metabolic Stress	12
Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement	11
BAG3 in the Heart	11
Who Should Be Accountable for Scientific Accountability?	11
Shielding the Heart	11
Publisher’s Note	11
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension	11
Tit for TAK1	11
Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1–Deficient Mice	11
Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm	11
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction	11
Paradoxical Effect of Caloric Restriction on Overload-Induced Muscle Growth in Diastolic Heart Failure	11
Effect of Semaglutide on Epicardial Adipogenesis and hiPSC-Atrial Cardiomyocytes New Hope in Targeting Epicardial Adipose Tissue	11
Is Obesity a Major Driver of Primary Aldosteronism?	10
Inhibition of Factor XI Using RBD4059	10
A (Alpha1-Adrenergic Receptors), B (Blocking Alpha1-Adrenergic Receptors), C (Catecholamines)	10
New Insights in the Pathology of Chronic Thromboembolic Pulmonary Hypertension	10

Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise	10
Unmasking Hormonal Mechanisms of Hypertension in Obesity	10
Cardiorenal Hemodynamic Coupling	10
The Cardiac Circadian Clock	10
New Insights Into the Therapy for Lamin-Associated Dilated Cardiomyopathy	10
Editorial Board	10
Low-Grade Inflammation	10
Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health	10
Recognizing Early Career Translational Investigators	10
Myocardial Infarction Platelet Gene Expression Signatures in Women	10
Introducing the 2024 THT Shark Tank Edition of JACC: Basic to Translational Science	10
Editorial Board	10
Full Issue PDF	10
Translating Imaging Into 3D Printed Cardiovascular Phantoms	10
High Maternal Glycine Levels Increase the Risk of Developing Atrial Septal Defect in the Offspring	10
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy	9
Heart Failure Solutions	9
Full Issue PDF	9
Full Issue PDF	9
Associations of Epigenetic Age Acceleration With CVD Risks Across the Lifespan	9
The Antioxidant Vitamin B12 Analogue Cobinamide as a Treatment for Marfan Syndrome	9
The Imperative to Enhance Cost-Effectiveness for Cardiovascular Therapeutic Development	9
Editorial Board	9
Editorial Board	9
Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids	9
Accelerated Turnover of Collagens and Other Extracellular Matrix Proteins Upon Chronic Beta-Adrenergic Stimulation	9
Will Gene Editing Orphanize Rare Diseases?	9
JACC Journals’ Pathway Forward With AI Tools	8
PCSK9 Inhibition	8
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction	8
Macrophage-Specific SPP1 Contributes to Pressure Overload–Induced Cardiac Dysfunction and Maladaptive Remodeling	8
Proteome-Wide Genetic Investigation of Large Artery Stiffness	8
Mitophagy Regulators as Novel Targets in Sepsis-Induced Myocardial Dysfunction	8
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes	8
The Emerging Role of Circular RNAs in Cardio-Oncology	8
Controlled Right Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy	8
Platelet-Derived Growth Factors	8
A Novel Device for Tricuspid Regurgitation Reduction Featuring 3-Dimensional Leaflet and Atraumatic Anchor	8
Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling	7
Strengths and Limitations of the Renal Locoregional Perfusion Platform	7
Are 3 Aorta Pumps Better Than 1 Transaortic to Preserve Von Willebrand Factor?	7
Editorial Board	7
INKing the Cardiotoxicity Out of Doxorubicin	7
Clonal Hematopoiesis and Transcatheter Aortic Valve Replacement	7
Vagus Nerve Stimulation for Myocardial Ischemia	7
In Memory of Dr Gary D. Lopaschuk, PhD (1955–2025)	7
Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase	7
Reply	7
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models	7
Dysregulation of IL-6/MCP-1/STAT3 Axis	7
Mitochondrial Targeted Therapies to Prevent Maternal Diabetes–Induced Congenital Heart Defects	7
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury	7
Deep Image Segmentation for Cardiomyocyte Proliferation	7
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy	7
The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support	7
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction	7
Editorial Board	7
The Pathology of Primary Mitral Regurgitation	7
OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration	7
Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections	6
Revitalizing Innovation	6
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF	6
Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction	6
Exploring Mechanisms of Pulmonary Artery Banding in a Rat Model of Dilated Cardiomyopathy	6
Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure	6
Natriuretic Peptides and Metabolic Hypertension	6
Recognizing Early Career Translational Investigators	6
The Technique of Permanent Pericardial Catheter in Mice	6
Moving Beyond the Hype in Extracellular Vesicle Therapy	6
Cardiovascular Research in Friedreich Ataxia	6
A New Ex Vivo Model to Study Cardiac Fibrosis in Whole Mouse Hearts	6
Mitochondrial Calcium Flux—Friend or Foe in Chronic Heart Failure?	6
Full Issue PDF	6
ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity	6
HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells	6
The Enigmata of Cardioprotection With SGLT2 Inhibition	6
Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis	6