JACC-Basic to Translational Science

Article	Citations
Recognizing Early Career Translational Investigators	118
Unveiling the PGAM5-ANGPTL3 Axis	106
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress	91
Reducing Plasma Factor XI Concentration With siRNA Technology	86
CXC-Chemokine-Receptor-Type-5 Expression on Circulating Naive B Cells Predicts Improvement After Cardiac Resynchronization Therapy	72
Is it Time to Abandon the Use of P-Values in Early Phase Translational Trials: Why (Effect) Size Matters	66
Editorial Board	60
When Off-Target Is the Target	58
1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model	58
Full Issue PDF	53
Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model Induced by Bilateral Pulmonary Vein Banding	50
JACC: Basic to Translational Science 2016-2025	50
Editorial Board	48
New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology	44
Mitochondrial DNA in Uremia and New Targets to Treat Myocardial Hypertrophy in the Cardiorenal Syndrome	44
Targeting Syntaxin 17 to Improve Mitophagy in Heart Failure	43
Reading a Good Transcript Soothes MYZAPed Heart	41
A Potential New Therapeutic Direction for Fibrosis in the Injured Heart Orchestrated by Cardiac MSCs	40
PD-1 Checkmate and the 2-Edged Sword of the Immune System	40
Is Laser Doppler Perfusion Imaging Truly a “Gold Standard” for Preclinical Peripheral Artery Disease Research?	40
Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome	39
Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment	38
Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability to Cause Aortopathy	37
Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2 Clonal Hematopoiesis	36
Full Issue PDF	36

Can Vaccination Prevent the Development of Chagas Disease Cardiomyopathy?	36
New Drug-Coated Balloons on the Horizon	36
Interorganellar Ca2+ Flux Assessment by Flow Cytometry Reveals an Altered Mitochondrial Ca2+ Homeostasis in Circulating Lymphocytes of STEMI Patients	36
Recognizing Early Career Translational Investigators	35
Addressing the Reproducibility Crisis in Science	35
Full Issue PDF	34
The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression	34
SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics	31
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms	31
Antibody Matrimony in a Duel of Hearts	31
6-Month Evaluation of a Transcatheter Aortic Valve (Myval) in a Novel Ovine, Supra-Aortic Banding Model	30
Is Endogenous Fibrinolysis a Major Player in Occurrence of Atherothrombotic Events Following Acute Myocardial Infarction?	30
ApoM Activates Autophagy and Suppresses Lyosomal Lethargy to Combat Doxorubicin Cardiomyopathy	30
Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure	29
Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis	29
Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart	29
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction	28
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism	28
Systems Biology Identifies TARS2 as a Cardiomyocyte Regulator of Mitochondrial Oxidative Stress in Dilated Cardiomyopathy	28
Endocardial Fibrosis Elastosis	27
Interferon Interrupted	27
Editorial Board	27
Soluble Programmed Death-1 Predicts Clinical Outcome After STEMI	27
Large Animal Models for Transcatheter Heart Valve Prosthesis Development	26
Red Blood Cell-Mediated Cardioprotection Is Impaired in ST-Segment Elevation Myocardial Infarction Patients With Anemia	26
Phosphoglycerate Mutase 5 Is Important Mediator for Instigating Arterial Lipid Accumulation and Aggravating Atherosclerosis	25
From Risk to Remedy?	25
C-Type Natriuretic Peptide in Essential Hypertension	25
Pulsatile ECMO	25
ATP-Citrate Lyase in Heart Failure	24
Inhibiting Serotonin to Treat Pulmonary Arterial Hypertension	23
Should All Translational Scientists Be Swifties?	22
The Farm to Table HFpEF Kitchen	21
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation	21
Reply	21
Reply	21
Reply	21
A Differentiated Approach Delivering Targeted Thrombectomy for VTE	21
From Colon to Aortic Aneurysm: Trek of the Treg	21
Full Issue Pdf	21
Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling	20
Lower Extremity Lymphatic Flow/Drainage Assessment by Indocyanine Green Fluorescent Lymphography in Heart Failure Patients	20
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation	20
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction	19
When Facts Become Forbidden	19
Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications	19
A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification	19
Fir(e)ing the Rhythm	18
The Virtual Patient Simulator	18
Proteomics of Large Artery Stiffness	18

Full Issue PDF	18
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules	18
CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction	18
Real-Time Revolution	17
A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes	17
IL-6 Inhibitors and TNF Inhibitors	17
Tissue Engineered Vascular Grafts	17
Reassessing the Mechanisms of PLN-R14del Cardiomyopathy	17
The Impact of Semaglutide on Cardiac Mass and Function Requires Further Investigation	17
Full Issue PDF	17
Full Issue Pdf	16
JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude	16
Full Issue PDF	16
Full Issue PDF	15
Pulsatile Ventricular Assist Platform	15
Recognizing Early Career Translational Investigators	15
The Past, Present, and Promising Future of Direct Cardiac Compression Devices	15
Ticagrelor Antibiotic Effect	15
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2	15
RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction	15
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction	15
Small Molecule Activators of Mitochondrial Fusion Prevent Congenital Heart Defects Induced by Maternal Diabetes	15
Noninvasive Cardiovascular Imaging in Preclinical Research	15
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation	15
Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats	14
Editorial Board	14
GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis	14
Introducing the 2024 Transcatheter Cardiovascular Therapeutics (TCT) Shark Tank Presentations	14
Editorial Board	14
Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling	14
Full Issue PDF	14
Reverse Translation of Pericardial Access	14
Where Comity in Science Goes to Die	14
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease	13
Turn(over) the Page	13
Experimental Models of Hypertrophic Cardiomyopathy	13
A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity	13
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease	13
Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure	13
Synbiotics and Gut-Heart Axis in Cardiometabolic Disease	13
Structural and Functional Adaptations to Exercise Training	13
Quality Over Quantity	13
Charting New Real Estate	12
Autonomic Modulation of Atrial Fibrillation	12
GLP-1 Receptor Agonists, the Holy Grail Preventing Atrial Fibrillation in Patients With T2D?	12
Full Issue PDF	12
Editorial Board	12
Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model	12
Decoding MTSS1	12
FNDC4 Prevents Aging-Related Cardiac Dysfunction	12
Editorial Board	12
JACC: Basic to Translational Science 2024 Thomas Force Young Investigator Award Winner	12
TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla	12
Macrophage Mayhem in Aortic Aneurysm	12
Partial Heart Transplant Growth and Hemodynamic Function in Piglets	12
Effect of Semaglutide on Epicardial Adipogenesis and hiPSC-Atrial Cardiomyocytes New Hope in Targeting Epicardial Adipose Tissue	11
Atrial Metabolic Stress	11
BAG3 in the Heart	11
Minimally Invasive Aortic Regurgitation Surgery	11
Publisher's Note	11
Remembering Ada L. Steininger	11
Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm	11
Full Issue PDF	11
Recognizing Early Career Translational Investigators	11
Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement	11
Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1–Deficient Mice	11
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury	11
Who Should Be Accountable for Scientific Accountability?	10
Animal Models in Biomedical Research	10
Myocardial Infarction Platelet Gene Expression Signatures in Women	10
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction	10
Tit for TAK1	10
Shielding the Heart	10
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload	10
Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation	10
Paradoxical Effect of Caloric Restriction on Overload-Induced Muscle Growth in Diastolic Heart Failure	10
Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis	10
Inhibition of Factor XI Using RBD4059	10
In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections	10
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension	9

Recognizing Early Career Translational Investigators	9
The Cardiac Circadian Clock	9
High Maternal Glycine Levels Increase the Risk of Developing Atrial Septal Defect in the Offspring	9
Low-Grade Inflammation	9
New Insights in the Pathology of Chronic Thromboembolic Pulmonary Hypertension	9
Continuous Monitoring of Blood Pressure and Vascular Hemodynamic Properties With Miniature Extravascular Hall-Based Magnetic Sensor	9
Editorial Board	9
New Insights Into the Therapy for Lamin-Associated Dilated Cardiomyopathy	9
Editorial Board	9
The Imperative to Enhance Cost-Effectiveness for Cardiovascular Therapeutic Development	9
Is Obesity a Major Driver of Primary Aldosteronism?	9
Introducing the 2024 THT Shark Tank Edition of JACC: Basic to Translational Science	9
Full Issue PDF	9
A (Alpha1-Adrenergic Receptors), B (Blocking Alpha1-Adrenergic Receptors), C (Catecholamines)	9
Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health	9
Cardiovascular Disease in Duchenne Muscular Dystrophy	9
Translating Imaging Into 3D Printed Cardiovascular Phantoms	8
Editorial Board	8
Full Issue PDF	8
Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase	8
Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise	8
Full Issue PDF	8
Will Gene Editing Orphanize Rare Diseases?	8
Are 3 Aorta Pumps Better Than 1 Transaortic to Preserve Von Willebrand Factor?	8
The Antioxidant Vitamin B12 Analogue Cobinamide as a Treatment for Marfan Syndrome	8
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy	8
Unmasking Hormonal Mechanisms of Hypertension in Obesity	8
Editorial Board	8
Red Blood Cell Transfusion and Cardiac Surgery–Associated Acute Kidney Injury	8
Associations of Epigenetic Age Acceleration With CVD Risks Across the Lifespan	8
Platelet-Derived Growth Factors	8
Controlled Right Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy	7
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes	7
Proteome-Wide Genetic Investigation of Large Artery Stiffness	7
PCSK9 Inhibition	7
Heart Failure Solutions	7
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy	7
In Memory of Dr Gary D. Lopaschuk, PhD (1955–2025)	7
The Emerging Role of Circular RNAs in Cardio-Oncology	7
A Novel Device for Tricuspid Regurgitation Reduction Featuring 3-Dimensional Leaflet and Atraumatic Anchor	7
Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation	7
Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids	7
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models	7
Editorial Board	7
JACC Journals’ Pathway Forward With AI Tools	7
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction	7
Mitophagy Regulators as Novel Targets in Sepsis-Induced Myocardial Dysfunction	7
Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling	7
Deep Image Segmentation for Cardiomyocyte Proliferation	7
Natriuretic Peptides and Metabolic Hypertension	6
Editorial Board	6
The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support	6
Vagus Nerve Stimulation for Myocardial Ischemia	6
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction	6
INKing the Cardiotoxicity Out of Doxorubicin	6
Dysregulation of IL-6/MCP-1/STAT3 Axis	6
Mitochondrial Targeted Therapies to Prevent Maternal Diabetes–Induced Congenital Heart Defects	6
OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration	6
Cardiovascular Research in Friedreich Ataxia	6
Clonal Hematopoiesis and Transcatheter Aortic Valve Replacement	6
The Pathology of Primary Mitral Regurgitation	6
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury	6
Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis	6
Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure	6
Exploring Mechanisms of Pulmonary Artery Banding in a Rat Model of Dilated Cardiomyopathy	6