OOIR: Observatory of International Research

Papers

(The TQCC of JACC-Basic to Translational Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients	151
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis	117
Decentralized Clinical Trials	84
Targeting the Inflammasome in Cardiovascular Disease	68
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury	65
Optimizing Foundational Therapies in Patients With HFrEF	61
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury	58
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection	58
Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies	57
Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals	57
Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction	56
The Role of NLRP3 Inflammasome in Pericarditis	52
Artificial Intelligence Discusses the Role of Artificial Intelligence in Translational Medicine	51
Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection	50
Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension	48
B Cells in Atherosclerosis	46
Myopathic Cardiac Genotypes Increase Risk for Myocarditis	41
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves	41
Antisense Inhibition of Angiotensinogen With IONIS-AGT-LRx	40
Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension	35
Neprilysin Inhibitors in Heart Failure	35
TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+ T Lymphocytes During Ischemic Heart Failure	35
Bias in Medicine	35
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction	32
Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency	31

Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction	30
Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk	30
Fir(e)ing the Rhythm	30
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells	29
Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities	27
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension	27
Proteomic Architecture of Valvular Extracellular Matrix	27
H2 Inhibits the Formation of Neutrophil Extracellular Traps	26
Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction	26
Erythrocytes Induce Vascular Dysfunction in COVID-19	26
Translation of New and Emerging Therapies for Genetic Cardiomyopathies	26
Cardio-Oncology	25
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction	25
Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve Calcification	25
Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19	24
Characterization of Cardiac Sympathetic Nervous System and Inflammatory Activation in HFpEF Patients	24
Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells	24
Micro-RNA Analysis in Pulmonary Arterial Hypertension	23
A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants	23
Animal Models of Neointimal Hyperplasia and Restenosis	22
Cardiovascular Disease in Duchenne Muscular Dystrophy	22
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation	21
Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass	21
With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension	21
Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model	21
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease	20
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction	20
Metabolomic Signature of Human Aortic Valve Stenosis	20
Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury	20
Genetic Risk Stratification	20
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women	19
Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition	19
Macrophage Polarization as a Novel Therapeutic Target for Endovascular Intervention in Peripheral Artery Disease	19
Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa–PAR2-Mediated Autophagy Suppression	19
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications	18
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction	18
Migraine in Patients Undergoing PFO Closure	18
Multiorgan Damage in Patients With COVID-19	18
Update on Cardioprotective Strategies for STEMI	17
Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice	17
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models	16
Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection	16
Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension	16
Acute Ischemia Alters Human Pericardial Fluid Immune Cell Composition	15
Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting	15
Translating Imaging Into 3D Printed Cardiovascular Phantoms	15
PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension	15
Fallacies of Using the Win Ratio in Cardiovascular Trials	15
Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction	15
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload	15

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation	15
Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure	15
Exercise Training and Revascularization in the Management of Symptomatic Peripheral Artery Disease	14
Immunometabolism at the Heart of Cardiovascular Disease	14
Cardiovascular Research in Friedreich Ataxia	14
Cardiac Xenotransplantation	13
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation	13
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis	13
RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO	13
3-Dimensional Bioprinting of Cardiovascular Tissues	13
Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination	13
Molecular Signature of HFpEF	13
Utilization and Potential of RNA-Based Therapies in Cardiovascular Disease	13
Landscape of Mentorship and its Effects on Success in Cardiology	13
Western Diet Causes Heart Failure With Reduced Ejection Fraction and Metabolic Shifts After Diastolic Dysfunction and Novel Cardiac Lipid Derangements	13
Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms	13
Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction	13
Novel IVC Doraya Catheter Provides Congestion Relief in Patients With Acute Heart Failure	12
STOP-HF Trial	12
Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System	12
Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis	12
β-Arrestin–Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate	12
Short-Chain Carbon Sources	12
Long-Term Strenuous Exercise Promotes Vascular Injury by Selectively Damaging the Tunica Media	12
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure	12
The Programmed Death-1 Signaling Axis Modulates Inflammation and LV Structure/Function in a Stress-Induced Cardiomyopathy Model	11
Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice	11
Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction	11
Inefficient Batteries in Heart Failure	11
MLb-LDLr	11
β-Arrestin–Mediated Angiotensin II Type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension	11
PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis	11
Glucagon-Like Peptide-1 Protects Against Atrial Fibrillation and Atrial Remodeling in Type 2 Diabetic Mice	11
Off-Label Use vs Off-Label Marketing of Drugs	11
LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice	10
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury	10
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction	10
Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling	10
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules	10
Platelets	10
Abnormalities in the Von Willebrand-Angiopoietin Axis Contribute to Dysregulated Angiogenesis and Angiodysplasia in Children With a Glenn Circulation	10
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism	10
Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery	9
Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration	9
Splanchnic Nerve Ablation for Volume Management in Heart Failure	9
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3	9
Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response	9
The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF	9
Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?	9
Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction	9
Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart	8
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment	8
Cardiac Pulmonary Nerve Stimulation (CPNSTM)	8
Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury	8
Linagliptin, A Xanthine-Based Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Experimental Autoimmune Myocarditis	8
SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function	8
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress	8
A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition	7
A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity	7
Coronary Flow Reserve, Inflammation, and Myocardial Strain	7
Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes	7
Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease	7
DAPA-CKD	7
Diagnostic and Therapeutic Aptamers	7
IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease	7
Sex-Dependent Effect of Platelet Nitric Oxide	7
Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome	7
FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo	7
Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation	7
PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction	7
Data Safety and Monitoring Boards Should Be Required for Both Early- and Late-Phase Clinical Trials	7
Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels	7
Recurrent Myocardial Injury Leads to Disease Tolerance in a Murine Model of Stress-Induced Cardiomyopathy	6
Vascular Inflammation and Hyperlipidemia	6
Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation	6
Antiplatelet Effects of Clopidogrel Vs Aspirin in Virologically Controlled HIV	6
Calcification in Pulmonary Heart Valve Tissue Engineering	6
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction	6
Advances in Clinical Imaging of Vascular Inflammation	6
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction	6

Validation of a Novel Renal Denervation System With Cryoablation	6
Reshaping the Ventricle From Within	6
Empagliflozin Suppresses the Differentiation/Maturation of Human Epicardial Preadipocytes and Improves Paracrine Secretome Profile	6
Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction	6
A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification	6
Feasibility Study of a Novel Transcatheter Tricuspid Annuloplasty System in a Porcine Model	6
The Cardiac Circadian Clock	6
Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post–Myocardial Infarction	6
Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation	6
Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification	5
Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide	5
Calcific Aortic Valve Disease “Omics” Is Timely, But Are We Looking Too Late?	5
Understanding HFpEF With Obesity	5
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms	5
Platelets and the Endothelium	5
zDHHC9 Regulates Cardiomyocyte Rab3a Activity and Atrial Natriuretic Peptide Secretion Through Palmitoylation of Rab3gap1	5
Audicor Remote Patient Monitoring	5
Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating	5
RNA Vaccines for COVID-19	5
Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease	5
A Novel Multisensor Device for Absolute Intracardiac Pressure Measurement, Detection, and Management of Heart Failure	5
Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies	5
Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction	5
Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation	5
Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease	5
Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise	4
Clustering of Cardiac Transcriptome Profiles Reveals Unique	4
Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models	4
Advancing Prediction of Pathogenicity of Familial Hypercholesterolemia LDL Receptor Commonest Variants With Machine Learning Models	4
The Essential Vulnerability of Human Cardiac Myocytes to SARS-CoV-2	4
Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine	4
Wharton’s Jelly–Mesenchymal Stem Cell–Engineered Conduit for Pulmonary Artery Reconstruction in Growing Piglets	4
Clonal Expansion in Cardiovascular Pathology	4
A Glimpse Into the Future of Transcatheter Interventional Heart Failure Therapies	4
Bioprosthetic Valve Deterioration	4
Micronized Acellular Matrix Biomaterial Leverages Eosinophils for Postinfarct Cardiac Repair	4
Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats	4
Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure	4
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction	4
High-Throughput Microscopy Characterization of Rare LDLR Variants	4
Beneficial Effects of Low-Intensity Pulsed Ultrasound Therapy on Right Ventricular Dysfunction in Animal Models	4
Immunomodulation of Myocardial Fibrosis	4
Transfusion-Related Renal Dysfunction After Cardiac Surgery	4
Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling	4
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2	4
Macrophage-Specific NLRC5 Protects From Cardiac Remodeling Through Interaction With HSPA8	4
In Situ Heart Valve Tissue Engineering	4