JACC-Basic to Translational Science

Papers
(The median citation count of JACC-Basic to Translational Science is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients151
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis117
Decentralized Clinical Trials84
Targeting the Inflammasome in Cardiovascular Disease68
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury65
Optimizing Foundational Therapies in Patients With HFrEF61
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection58
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury58
Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies57
Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals57
Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction56
The Role of NLRP3 Inflammasome in Pericarditis52
Artificial Intelligence Discusses the Role of Artificial Intelligence in Translational Medicine51
Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection50
Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension48
B Cells in Atherosclerosis46
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves41
Myopathic Cardiac Genotypes Increase Risk for Myocarditis41
Antisense Inhibition of Angiotensinogen With IONIS-AGT-LRx40
Bias in Medicine35
Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension35
Neprilysin Inhibitors in Heart Failure35
TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+ T Lymphocytes During Ischemic Heart Failure35
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction32
Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency31
Fir(e)ing the Rhythm30
Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction30
Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk30
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells29
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension27
Proteomic Architecture of Valvular Extracellular Matrix27
Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities27
Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction26
Erythrocytes Induce Vascular Dysfunction in COVID-1926
Translation of New and Emerging Therapies for Genetic Cardiomyopathies26
H2 Inhibits the Formation of Neutrophil Extracellular Traps26
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction25
Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve Calcification25
Cardio-Oncology25
Characterization of Cardiac Sympathetic Nervous System and Inflammatory Activation in HFpEF Patients24
Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells24
Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-1924
A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants23
Micro-RNA Analysis in Pulmonary Arterial Hypertension23
Cardiovascular Disease in Duchenne Muscular Dystrophy22
Animal Models of Neointimal Hyperplasia and Restenosis22
With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension21
Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model21
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation21
Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass21
Genetic Risk Stratification20
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease20
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction20
Metabolomic Signature of Human Aortic Valve Stenosis20
Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury20
Macrophage Polarization as a Novel Therapeutic Target for Endovascular Intervention in Peripheral Artery Disease19
Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa–PAR2-Mediated Autophagy Suppression19
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women19
Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition19
Multiorgan Damage in Patients With COVID-1918
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications18
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction18
Migraine in Patients Undergoing PFO Closure18
Update on Cardioprotective Strategies for STEMI17
Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice17
Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection16
Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension16
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models16
PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension15
Fallacies of Using the Win Ratio in Cardiovascular Trials15
Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction15
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload15
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation15
Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure15
Acute Ischemia Alters Human Pericardial Fluid Immune Cell Composition15
Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting15
Translating Imaging Into 3D Printed Cardiovascular Phantoms15
Cardiovascular Research in Friedreich Ataxia14
Exercise Training and Revascularization in the Management of Symptomatic Peripheral Artery Disease14
Immunometabolism at the Heart of Cardiovascular Disease14
3-Dimensional Bioprinting of Cardiovascular Tissues13
Western Diet Causes Heart Failure With Reduced Ejection Fraction and Metabolic Shifts After Diastolic Dysfunction and Novel Cardiac Lipid Derangements13
Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms13
Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction13
Utilization and Potential of RNA-Based Therapies in Cardiovascular Disease13
Landscape of Mentorship and its Effects on Success in Cardiology13
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation13
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis13
RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO13
Cardiac Xenotransplantation13
Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination13
Molecular Signature of HFpEF13
Novel IVC Doraya Catheter Provides Congestion Relief in Patients With Acute Heart Failure12
STOP-HF Trial12
Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System12
Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis12
β-Arrestin–Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate12
Short-Chain Carbon Sources12
Long-Term Strenuous Exercise Promotes Vascular Injury by Selectively Damaging the Tunica Media12
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure12
Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice11
Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction11
Inefficient Batteries in Heart Failure11
MLb-LDLr11
β-Arrestin–Mediated Angiotensin II Type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension11
PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis11
Glucagon-Like Peptide-1 Protects Against Atrial Fibrillation and Atrial Remodeling in Type 2 Diabetic Mice11
Off-Label Use vs Off-Label Marketing of Drugs11
The Programmed Death-1 Signaling Axis Modulates Inflammation and LV Structure/Function in a Stress-Induced Cardiomyopathy Model11
Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling10
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules10
Platelets10
Abnormalities in the Von Willebrand-Angiopoietin Axis Contribute to Dysregulated Angiogenesis and Angiodysplasia in Children With a Glenn Circulation10
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism10
LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice10
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury10
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction10
Splanchnic Nerve Ablation for Volume Management in Heart Failure9
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H39
Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response9
The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF9
Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?9
Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction9
Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery9
Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration9
Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart8
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment8
Cardiac Pulmonary Nerve Stimulation (CPNSTM)8
Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury8
Linagliptin, A Xanthine-Based Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Experimental Autoimmune Myocarditis8
SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function8
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress8
Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes7
Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease7
DAPA-CKD7
Diagnostic and Therapeutic Aptamers7
IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease7
Sex-Dependent Effect of Platelet Nitric Oxide7
Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome7
FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo7
Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation7
PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction7
Data Safety and Monitoring Boards Should Be Required for Both Early- and Late-Phase Clinical Trials7
Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels7
A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition7
A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity7
Coronary Flow Reserve, Inflammation, and Myocardial Strain7
Antiplatelet Effects of Clopidogrel Vs Aspirin in Virologically Controlled HIV6
Calcification in Pulmonary Heart Valve Tissue Engineering6
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction6
Advances in Clinical Imaging of Vascular Inflammation6
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction6
Validation of a Novel Renal Denervation System With Cryoablation6
Reshaping the Ventricle From Within6
Empagliflozin Suppresses the Differentiation/Maturation of Human Epicardial Preadipocytes and Improves Paracrine Secretome Profile6
Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction6
A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification6
Feasibility Study of a Novel Transcatheter Tricuspid Annuloplasty System in a Porcine Model6
The Cardiac Circadian Clock6
Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post–Myocardial Infarction6
Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation6
Recurrent Myocardial Injury Leads to Disease Tolerance in a Murine Model of Stress-Induced Cardiomyopathy6
Vascular Inflammation and Hyperlipidemia6
Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation6
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms5
Platelets and the Endothelium5
Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification5
Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide5
Audicor Remote Patient Monitoring5
Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating5
RNA Vaccines for COVID-195
Cardiac Transcriptome Remodeling and Impaired Bioenergetics in Single-Ventricle Congenital Heart Disease5
zDHHC9 Regulates Cardiomyocyte Rab3a Activity and Atrial Natriuretic Peptide Secretion Through Palmitoylation of Rab3gap15
Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies5
Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction5
Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation5
Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease5
A Novel Multisensor Device for Absolute Intracardiac Pressure Measurement, Detection, and Management of Heart Failure5
Calcific Aortic Valve Disease “Omics” Is Timely, But Are We Looking Too Late?5
Understanding HFpEF With Obesity5
Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling4
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 24
Macrophage-Specific NLRC5 Protects From Cardiac Remodeling Through Interaction With HSPA84
In Situ Heart Valve Tissue Engineering4
Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise4
Clustering of Cardiac Transcriptome Profiles Reveals Unique4
Multiparametric Immunoimaging Maps Inflammatory Signatures in Murine Myocardial Infarction Models4
Advancing Prediction of Pathogenicity of Familial Hypercholesterolemia LDL Receptor Commonest Variants With Machine Learning Models4
The Essential Vulnerability of Human Cardiac Myocytes to SARS-CoV-24
Downstream Paclitaxel Released Following Drug-Coated Balloon Inflation and Distal Limb Wound Healing in Swine4
Wharton’s Jelly–Mesenchymal Stem Cell–Engineered Conduit for Pulmonary Artery Reconstruction in Growing Piglets4
Clonal Expansion in Cardiovascular Pathology4
A Glimpse Into the Future of Transcatheter Interventional Heart Failure Therapies4
Bioprosthetic Valve Deterioration4
Micronized Acellular Matrix Biomaterial Leverages Eosinophils for Postinfarct Cardiac Repair4
Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats4
Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure4
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction4
High-Throughput Microscopy Characterization of Rare LDLR Variants4
Beneficial Effects of Low-Intensity Pulsed Ultrasound Therapy on Right Ventricular Dysfunction in Animal Models4
Immunomodulation of Myocardial Fibrosis4
Transfusion-Related Renal Dysfunction After Cardiac Surgery4
Endothelium-Mimetic Surface Modification Improves Antithrombogenicity and Enhances Patency of Vascular Grafts in Rats and Pigs3
Pleiotropic, Cellular Effects of Rivaroxaban on Autophagy Explain Atheroprotective Effects3
Do Genes Influence Susceptibility to Myocarditis?3
Large Animal Models for Transcatheter Heart Valve Prosthesis Development3
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy3
Apolipoprotein A-I for Cardiac Recovery Post–Myocardial Infarction3
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes3
Genetic Testing in Familial Hypercholesterolemia3
Loss of YTHDF2 Alters the Expression of m6A-Modified Myzap and Causes Adverse Cardiac Remodeling3
Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition3
Use of Proximity Labeling in Cardiovascular Research3
Loss of Bone Morphogenetic Protein-9 Reduces Survival and Increases MMP Activity After Myocardial Infarction3
Sodium Thiosulfate in Acute Myocardial Infarction3
Liraglutide Lowers Endothelial Vascular Cell Adhesion Molecule-1 in Murine Atherosclerosis Independent of Glucose Levels3
First-in-Human Experience of Mechanical Preload Control in Patients With HFpEF During Exercise3
Right Ventricular Fibrosis After Tetralogy of Fallot Repair3
Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling3
A Novel Device for Tricuspid Regurgitation Reduction Featuring 3-Dimensional Leaflet and Atraumatic Anchor3
Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis3
Endothelial Overexpression of TGF-β-Induced Protein Impairs Venous Thrombus Resolution3
Novel Noninvasive Biosensors and Artificial Intelligence for Optimized Heart Failure Management3
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension3
Autonomic Modulation of Atrial Fibrillation3
Cardiac Transduction in Mini-Pigs After Low-Dose Retrograde Coronary Sinus Infusion of AAV9-BAG33
When Sensing Goes Wrong3
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation3
Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases3
Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF3
Metabolomic Signatures of Myocardial Glucose Uptake on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography3
Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology3
New Insights Into the Therapy for Lamin-Associated Dilated Cardiomyopathy3
1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model3
Targeting the Lymphatic System for Interstitial Decongestion3
Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels3
Exercise at the Extremes3
Inflammatory Effects of Triglycerides2
Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients2
Cardiac Lymphatic Insufficiency Leads to Diastolic Dysfunction Via Myocardial Morphologic Change2
Electroanatomical Navigation to Minimize Contrast Medium or X-Rays During Stenting2
The Quest for an Early Marker of Anthracycline-Induced Cardiotoxicity2
Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy2
What Are the Clinical Implications of the SARS-CoV-2 Variants2
Cardiac Adrenergic Activation in Heart Failure With Preserved Ejection Fraction2
Murine Ischemia Reperfusion Without Endotracheal Intubation or Ventilation2
Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction2
NLRP3 Inflammasome Inhibition2
HIF-1α Cardioprotection in COVID-19 Patients2
Potential of AT1-R-Biased Agonists in Pediatric Heart Failure2
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