OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 70. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Application of bioactive materials primary cilia as a novel delivery vehicle	244
CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer	240
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	239
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	208
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	187
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	184
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	181
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	168
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	148
Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]	147
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	138
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	136
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	129
Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma	128
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	123
Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system	120
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	120
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	118
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	117
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	115
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	111
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	109
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation	107
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	107
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	106

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	105
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	103
Outside Front Cover	102
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	98
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	96
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	95
Fluorous oligoarginines as supra-enhancers for intracellular and transdermal peptide delivery	94
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	93
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	92
Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering	92
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	90
Bilayer vascular grafts separately loaded with sodium copper chlorophyllin and keratin-based hydrogen sulfide donor with pro-endothelialization, anti-thrombogenicity, anti-inflammation, and anti-calci	89
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	89
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	88
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	87
Sonotheranostic nanosideromycin eradicates bacterial biofilm infections via ultrasound-detonated ROS generation and ferroptosis-like death	86
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	86
A hierarchical MgF2/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents	85
Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration	83
An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer	82
Sulfated chitosan enhances BMP-2-mediated spinal fusion via skeletal stem cell rejuvenation in aging	81
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment	80
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect	80
Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair	80
Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis	80
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	76
Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications	75
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment	75
Fabrication and functional validation of a hybrid biomimetic nanovaccine (HBNV) against Kit-mutant melanoma	75
Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation	75
Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction	74
Additively manufactured metallic biomaterials	74
Esophagus extracellular matrix with microenvironmental complexity for esophageal organoids	74
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	73
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	72
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells	72
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	72
Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy	72
Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment	71
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	71
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	71
Conformationally regulated “nanozyme-like” cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration	70
An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation	70
Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury	70
Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury	70
Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials	70
Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation	70