OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Application of bioactive materials primary cilia as a novel delivery vehicle	341
Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]	301
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	231
Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy	219
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	219
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	218
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	183
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure	166
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density	165
Outside Front Cover	160
A hierarchical MgF2/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents	159
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	156
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	155
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	150
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	137
Sonotheranostic nanosideromycin eradicates bacterial biofilm infections via ultrasound-detonated ROS generation and ferroptosis-like death	132
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	126
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	122
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	120
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	116
Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering	115
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	114
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	112
Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing	110
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	109

Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	107
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	106
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	102
Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system	101
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	99
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	99
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	98
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	96
Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma	96
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	96
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	96
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	94
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	92
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	91
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	89
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	89
CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer	89
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation	88
Delivery of therapeutic oligonucleotides in nanoscale	88
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	88
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	86
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	85
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	85
Light-activated nanoclusters with tunable ROS for wound infection treatment	82
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	81
Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods	81
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	80
An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer	80
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	78
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells	78
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment	77
A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus	77
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis	76
Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy	75
Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells	75
An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation	73
Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment	73
Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content	73
Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair	72
Polymer-modified DNA hydrogels for living mitochondria and nanozyme delivery in the treatment of rheumatoid arthritis	71
Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects	71
Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis	70
Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration	70
3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration	69
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	69
Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity	69