OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 74. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Outside Front Cover	373
Application of bioactive materials primary cilia as a novel delivery vehicle	333
Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]	299
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	244
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	231
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	214
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure	213
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	211
Delivery of therapeutic oligonucleotides in nanoscale	205
Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system	182
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	169
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	162
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	155
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	154
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	154
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	152
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	151
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density	150
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	141
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	134
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	127
Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering	123
Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma	123
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	121
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	117

Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	112
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	110
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	109
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	109
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	108
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	107
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	107
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation	105
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	102
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	99
Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing	98
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	98
Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy	97
MoS2-based nanocomposites for cancer diagnosis and therapy	97
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	95
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	94
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	93
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	93
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	92
Polymer-modified DNA hydrogels for living mitochondria and nanozyme delivery in the treatment of rheumatoid arthritis	91
Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair	87
Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation	87
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	86
Strategic advances in Vat Photopolymerization for 3D printing of calcium phosphate-based bone scaffolds: A review	86
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	85
Light-activated nanoclusters with tunable ROS for wound infection treatment	85
Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods	84
Conformationally regulated “nanozyme-like” cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration	84
Advances in biomaterial-based tissue engineering for peripheral nerve injury repair	83
Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells	83
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	82
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	81
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect	81
A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus	80
Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy	80
Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages	79
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment	78
Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content	77
An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer	77
Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles	76
Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis	75
Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy	75
Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications	75
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures	75
3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration	75
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis	74
Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy	74
3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration	74
Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury	74
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment	74