OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 76. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	354
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	330
Outside Front Cover	301
Plasma-activated interfaces for biomedical engineering	289
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	225
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	220
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	206
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	202
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	196
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	190
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	163
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	160
Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy	157
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	153
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	150
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	149
Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma	147
Delivery of therapeutic oligonucleotides in nanoscale	145
T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance	142
A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle	140
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	137
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	131
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	131
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	125
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	124

Chinese herb microneedle patch for wound healing	123
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure	123
MoS2-based nanocomposites for cancer diagnosis and therapy	119
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	119
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	118
Injectable silk sericin scaffolds with programmable shape-memory property and neuro-differentiation-promoting activity for individualized brain repair of severe ischemic stroke	115
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	115
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	113
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density	111
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	110
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	107
Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing	105
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	103
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	103
Advances in biomaterial-based tissue engineering for peripheral nerve injury repair	103
Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content	100
Fabrication and functional validation of a hybrid biomimetic nanovaccine (HBNV) against Kit-mutant melanoma	100
Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials	98
Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment	98
A microporous surface containing Si3N4/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration	96
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	95
Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity	95
Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade	93
A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus	90
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment	89
Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy	89
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	88
Enhancing biocompatibility of the brain-machine interface: A review	87
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures	87
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	86
3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration	86
Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury	85
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	84
Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration	84
Polymer-modified DNA hydrogels for living mitochondria and nanozyme delivery in the treatment of rheumatoid arthritis	84
Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury	83
Hydroxyapatite reinforced inorganic-organic hybrid nanocomposite as high-performance adsorbents for bilirubin removal in vitro and in pig models	83
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells	83
Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure	82
Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy	82
Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods	81
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	80
Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction	80
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	79
Light-activated nanoclusters with tunable ROS for wound infection treatment	79
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment	78
Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair	78
Milestones and current achievements in development of multifunctional bioscaffolds for medical application	78
Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation	77
Conformationally regulated “nanozyme-like” cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration	77

Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects	77
3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration	76
Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells	76
3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration	76