OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 72. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	246
Application of bioactive materials primary cilia as a novel delivery vehicle	219
Outside Front Cover	198
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	194
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	186
Fluorous oligoarginines as supra-enhancers for intracellular and transdermal peptide delivery	157
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	155
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	154
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	150
Bilayer vascular grafts separately loaded with sodium copper chlorophyllin and keratin-based hydrogen sulfide donor with pro-endothelialization, anti-thrombogenicity, anti-inflammation, and anti-calci	143
Outside Front Cover	136
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	136
Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]	136
Sonotheranostic nanosideromycin eradicates bacterial biofilm infections via ultrasound-detonated ROS generation and ferroptosis-like death	129
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	128
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	127
A composite hydrogel enables the spatiotemporal delivery of distinct cytokines to drive the native vascularized bone regeneration	122
CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer	119
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	117
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	116
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	116
A hierarchical MgF2/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents	115
Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system	114
Dual-engineering metalloimmunotherapy mediates Staphylococcus aureus virulence silencing and biofilm immune microenvironment reprogramming against implant-associated infections	112
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	108

Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering	103
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	102
A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway	101
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	101
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	101
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	100
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	97
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	97
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	96
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	95
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	93
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation	93
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	92
Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma	90
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	89
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	88
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	87
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	87
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	86
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	85
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	85
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	84
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	83
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	83
Fabrication and functional validation of a hybrid biomimetic nanovaccine (HBNV) against Kit-mutant melanoma	80
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells	80
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	80
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	80
A catalytically active and recyclable bioelastomer inspired by metalloenzymes	79
Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects	79
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	79
Immunomodulatory effects of biodegradable Mg–Cu–Zn alloy in esophageal cancer	78
Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions	78
Three-dimensional printed PCL/nHA scaffolds promote soft tissue functional fibrosis to repair chest wall defect via Piezo1/Ca2+ signal during respiratory motion	78
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment	77
Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration	77
pH-neutralization strategy to suppress GPCR68 spatiotemporally activates T cells and enhances anti-tumor immunity	77
Conformationally regulated “nanozyme-like” cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration	77
Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction	77
Sulfated chitosan enhances BMP-2-mediated spinal fusion via skeletal stem cell rejuvenation in aging	76
Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment	76
Immunoregulatory protein-hybrid extracellular vesicles via self-loadable backbone cyclization for oral inflammatory bowel disease therapy	75
Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation	75
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment	75
Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury	74
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures	74
An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer	73
Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation	72
Real-time magnetic resonance visualization of tumor acidosis as a precognition indicator of therapeutic efficacy	72
Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration	72

Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices