OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 70. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Application of bioactive materials primary cilia as a novel delivery vehicle	377
Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]	331
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	298
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	229
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	216
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	215
Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering	214
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	206
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure	180
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density	173
Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma	160
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	159
Outside Front Cover	158
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	157
A hierarchical MgF2/polyurethane/pitavastatin coating alleviates degradation and enhances endothelialization of bioresorbable magnesium alloy stents	156
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	154
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	151
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	146
Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma	135
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	131
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	129
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	122
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	120
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	117
Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system	111

Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	111
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	111
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	110
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	105
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	103
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	103
CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer	102
Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing	101
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	98
Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy	97
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	96
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	96
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation	94
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	93
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	93
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	91
Delivery of therapeutic oligonucleotides in nanoscale	88
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	88
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	87
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	87
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	87
Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation	87
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	86
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	85
Light-activated nanoclusters with tunable ROS for wound infection treatment	84
Strategic advances in Vat Photopolymerization for 3D printing of calcium phosphate-based bone scaffolds: A review	84
Real-time magnetic resonance visualization of tumor acidosis as a precognition indicator of therapeutic efficacy	84
Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods	83
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures	82
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	81
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	80
An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer	80
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	78
Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy	78
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells	76
Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages	76
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment	75
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis	75
Enhancing biocompatibility of the brain-machine interface: A review	74
Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy	73
Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction	72
Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles	72
A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus	72
Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure	71
Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair	70