Cell Chemical Biology

Article	Citations
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA	137
30th anniversary celebrations: Inspiring innovation in biology and medicine	119
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	118
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	111
Synthetic gene circuit evolution: Insights and opportunities at the mid-scale	105
Tumor microenvironmental nutrients, cellular responses, and cancer	95
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	88
Engineering DNA-Templated Nonribosomal Peptide Synthesis	81
The physiological and pathological roles of RNA modifications in T cells	79
Restoring two tumor suppressor pathways with one PAWI	76
New sheriff in town: Cyclic peptide inhibitors of a DUB module	71
Antisense-mediated senseful regulation of orchestrated metabolic response	69
Chemically Induced Cell Wall Stapling in Bacteria	67
ND3 Cys39 in complex I is exposed during mitochondrial respiration	57
Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons	56
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	54
Shining light on reprogramming Tregs for cancer therapy	53
Advances and opportunities in targeted protein degradation	52
Inhibition of Nonfunctional Ras	51
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis	50
Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells	48
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria	48
Development of potent dimeric inhibitors of GAS41 YEATS domain	48
A versatile residue numbering scheme for Nav and Cav channels	48
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	48

Phenotypic technologies in stem cell biology	47
Carolyn Bertozzi: Building new bonds between molecules, fields, and communities	47
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	45
Engineered protein-small molecule conjugates empower selective enzyme inhibition	45
A new light on PLCβ!	44
A transcriptional relationship with a natural product disrupts mitochondrial biogenesis	44
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites	43
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	43
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics	42
Voices: Challenges and opportunities in regulating the immune system	42
Multi-protein complexes as drug targets	41
Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function	40
How to kill an ERKsome target: PROTACs deliver the deathblow	40
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	40
FLEX: genetically encodable enzymatic fluorescence signal amplification using engineered peroxidase	39
Degrading the signal amplifier: ITK as a target for targeted protein degradation	39
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin	37
Help! I need a WNT antibody. Help! Not just any antibody	37
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	35
Advancing protein therapeutics through proximity-induced chemistry	35
HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells	34
Generation of glycan-specific nanobodies	34
The role of SERPIN citrullination in thrombosis	33
Potent macrocycle inhibitors of the human SAGA deubiquitinating module	33
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues	33
Targeting allostery in the Dynein motor domain with small molecule inhibitors	33
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	33
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	32
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation	31
Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth	31
An engineered cereblon optimized for high throughput screening and molecular glue discovery	31
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	31
K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap	30
TK216 targets microtubules in Ewing sarcoma cells	30
The chemical tools for imaging dopamine release	30
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	30
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	30
Making the cut with protease engineering	29
Bioorthogonal dissection of the replicase assembly of hepatitis C virus	29
A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions	29
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	28
A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin	28
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	28
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	27
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	27
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	27
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells	26
New advisory board members speak on challenges and opportunities in chemical biology	26
Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics	26
Next steps for targeted protein degradation	25

Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome	25
Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice	25
Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction	25
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	25
HATS off to KAT6A/B inhibitors: A new way to target estrogen-receptor-positive breast cancer	25
Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID	25
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology	24
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization	24
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples	24
The impact of iron and heme availability on the healthy human gut microbiome in vivo and in vitro	24
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins	24
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor	24
Structural and mechanistic investigations of protein S-glycosyltransferases	23
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays	23
How to untie G-quadruplex knots and why?	23
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	22
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	22
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	22
Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth	22
Identifying and antagonizing the interactions between layilin and glycosylated collagens	22
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	22
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses	22
Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions	22
Avoid the trap: Targeting PARP1 beyond human malignancy	22
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation	21
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	21
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	21
Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer	21
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	21
HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson’s disease	21
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader	21
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	21
Host specific sphingomyelin is critical for replication of diverse RNA viruses	21
Covalent targeting of splicing in T cells	20
Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis	20
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	20
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function	20
2′-OH as a universal handle for studying intracellular RNAs	19
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	19
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway	19
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter	19
Excited to see you: New imaging approaches to detect ferrous iron in vivo	19
Autotaxin facilitates selective LPA receptor signaling	19
Break Away: FKBP12 sequestration as a target for increasing BMP activity	18
The chemistry of electrical signaling in sodium channels from bacteria and beyond	18
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates	18
Using chemical biology for targeting cancer	18
Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved	18
Meet the authors: Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, and Nieng Yan	18
Un-FASN-ing cancer’s seat belt: Linking lipid metabolism and antigen presentation	18
Sweet sensation: Developing a single-cell fluorescent reporter of glycolytic heterogeneity	18
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE	18
Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors	18
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria	18
AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells	18
Chemical control of multidomain acetyltransferase activity	17
A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation	17
Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors	17
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	17
Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion	17
Cell-selective bioorthogonal labeling	17
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury	17
When CDK4/6i meets GPX4i: Stop dividing to die iron hard	17
The role of reversible and irreversible covalent chemistry in targeted protein degradation	17
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	17
Chemical proteomics to study metabolism, a reductionist approach applied at the systems level	17
Periplasmic expression of SpyTagged antibody fragments enables rapid modular antibody assembly	16
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay	16
Fishing for a balance: Toward promyelinating drug discovery	16
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	16
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	16
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions	16
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	16
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors	16
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	15
Localization matters in targeted protein degradation	15
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain	15
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	15
Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor	15
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9	14

Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	14
Antiplasmodial peptaibols act through membrane directed mechanisms	14
Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics	14
Nuisance compounds in cellular assays	14
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance	14
Chemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins	14
Catalytic spike antibodies: A new paradigm in neutralization	14
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	14
Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation	14
PARP trapping is governed by the PARP inhibitor dissociation rate constant	14
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	14
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	13
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization	13
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A	13
Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity	13
Targeting selective E3 ligase for healing cardiac fibrosis	13
A phospholipid mimetic targeting LRH-1 ameliorates colitis	13
In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking	13
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer	13
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity	13
Combating the myth of “innate genius” in science	13
Voices: Challenges and opportunities for bioorthogonal chemistry	13
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I	13
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality	13
Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling	13
Utilizing directed evolution to interrogate and optimize CRISPR/Cas guide RNA scaffolds	13
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	13
Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage	13