Cell Chemical Biology

Article	Citations
Autophagy-Dependent Ferroptosis: Machinery and Regulation	396
PROTACs: An Emerging Therapeutic Modality in Precision Medicine	247
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis	217
The Chemistry and Biology of Ferroptosis	204
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis	142
Ferroptosis and Necroptosis in the Kidney	142
Targeted protein degradation: A promise for undruggable proteins	114
The Chemical Biology of Ferroptosis in the Central Nervous System	108
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells	99
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	93
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	86
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300	82
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	79
The Chemical Biology of Reversible Lysine Post-translational Modifications	77
Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit	71
Recent advances in identifying protein targets in drug discovery	70
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC	68
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	66
Selenium: Tracing Another Essential Element of Ferroptotic Cell Death	65
Chemical Tools for Endogenous Protein Labeling and Profiling	64
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	62
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells	62
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology	62
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis	61
Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming	60

Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	60
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP	57
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases	57
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics	56
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	56
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity	55
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders	51
The role of reversible and irreversible covalent chemistry in targeted protein degradation	51
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements	50
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	50
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	48
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	46
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity	45
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors	45
Context-dependent regulation of ferroptosis sensitivity	44
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton	44
Lanthanide-Based Optical Probes of Biological Systems	43
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins	42
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	42
How to untie G-quadruplex knots and why?	42
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases	42
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes	41
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System	41
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System	41
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention	40
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway	39
Systematic Chemogenetic Library Assembly	39
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	38
Morphological profiling of small molecules	37
The proteasome and its role in the nervous system	37
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A	37
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants	37
Nuisance compounds in cellular assays	37
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth	36
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors	36
Ubiquitin ligases in cancer: Functions and clinical potentials	35
Optical control of targeted protein degradation	34
A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast	34
A fine-tuned azobenzene for enhanced photopharmacology in vivo	34
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses	34
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches	33
Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies	32
Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy	32
Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3	32
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation	31
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	31
Decoding the messaging of the ubiquitin system using chemical and protein probes	31
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis	31
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy	31
DogCatcher allows loop-friendly protein-protein ligation	30

Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth	30
Exploring the target scope of KEAP1 E3 ligase-based PROTACs	29
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells	29
Quantitative Imaging of Labile Zn2+ in the Golgi Apparatus Using a Localizable Small-Molecule Fluorescent Probe	29
Targeted In Situ Protein Diversification and Intra-organelle Validation in Mammalian Cells	28
High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need	27
Chemical Biology Tools for Examining the Bacterial Cell Wall	27
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity	27
Small molecule targeting of biologically relevant RNA tertiary and quaternary structures	27
Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1	27
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering	27
Polynuclear Ruthenium Amines Inhibit K2P Channels via a “Finger in the Dam” Mechanism	27
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase	26
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death	26
Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification	26
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors	26
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein	26
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	25
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A	25
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	25
Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia	25
Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence	25
The future of phenotypic drug discovery	24
The chemical tools for imaging dopamine release	24
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	24
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	24
Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth	24
ND3 Cys39 in complex I is exposed during mitochondrial respiration	24
Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds	23
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex	23
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology	23
An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity	23
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex	23
Inhibition of Nonfunctional Ras	23
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals	23
Bifunctional modalities for repurposing protein function	23
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems	23
Human iPSC modeling of heart disease for drug development	22
Mechanism of Cell Penetration by Permeabilization of Late Endosomes: Interplay between a Multivalent TAT Peptide and Bis(monoacylglycero)phosphate	22
Piperlongumine conjugates induce targeted protein degradation	22
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin	22
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor	22
Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome	21
A photo-cross-linking GlcNAc analog enables covalent capture of N-linked glycoprotein-binding partners on the cell surface	21
Small-molecule allosteric inhibitors of GPX4	21
Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies	21
Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity	21
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis	21
Selective Modulation of Dynamic Protein Complexes	21
A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin	21
Chemoproteomic-enabled phenotypic screening	21
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA	21
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism	21
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	20
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions	20
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity	20
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality	20
Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel	20
Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine γ-lyase (CSE) represses trophoblast syncytialization	20
Engineering DNA-Templated Nonribosomal Peptide Synthesis	20
Identification of a PCSK9-LDLR disruptor peptide with in vivo function	19
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis	19
Making the cut with protease engineering	19
Target protein localization and its impact on PROTAC-mediated degradation	19
A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases	19
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1	19
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation	19
Selective autophagy as the basis of autophagy-based degraders	19
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors	19
TK216 targets microtubules in Ewing sarcoma cells	19
Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I	18
Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells	18
Identification and validation of selective deubiquitinase inhibitors	18
Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion	18
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors	18
Peptide-Based PROTAC: The Predator of Pathological Proteins	18
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing	18
Periplasmic expression of SpyTagged antibody fragments enables rapid modular antibody assembly	18
Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities	18
Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer	18

Re-defining synthetic lethality by phenotypic profiling for precision oncology	17
Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation	17
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	17
Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex	17
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator	17
Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells	17
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement	17
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	17
Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds	17
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling	17
A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity	16
Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches	16
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader	16
Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators	16
Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex	16
Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs	16
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190	16
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers	16
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	16