Cell Chemical Biology

Article	Citations
Antisense-mediated senseful regulation of orchestrated metabolic response	114
New sheriff in town: Cyclic peptide inhibitors of a DUB module	102
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	83
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	72
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples	72
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	71
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	67
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	66
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	66
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	66
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	65
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	65
2′-OH as a universal handle for studying intracellular RNAs	63
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	61
Voices: Challenges and opportunities in regulating the immune system	61
RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo	60
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	60
A versatile residue numbering scheme for Nav and Cav channels	60
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	58
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites	57
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	55
Next steps for targeted protein degradation	55
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	53
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	49
A fine-tuned azobenzene for enhanced photopharmacology in vivo	48

Catalytic spike antibodies: A new paradigm in neutralization	48
A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	47
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	47
A synthetic RNA-based biosensor for fructose-1,6-bisphosphate that reports glycolytic flux	47
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	46
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	46
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	45
Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad	44
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	43
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	42
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	42
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets	41
The art of designed coiled-coils for the regulation of mammalian cells	40
Pharmacological management of disease by overcoming structural adversity	40
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET	40
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	39
A double whammy for KEAP1	39
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	39
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	38
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	38
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics	37
Meet the authors: Aayushi Uberoi and Elizabeth A. Grice	36
Two sides of a co(i)ndensate	34
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	33
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets	33
A new chink in cancer’s armor: Unleashing cell death by selective PP5 inhibition	33
A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases	33
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs	32
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases	31
N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis	31
Shipworm symbiosis ecology-guided discovery of an antibiotic that kills colistin-resistant Acinetobacter	31
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation	31
Enabling inclusion and looking ahead	31
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome	31
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	30
Behavioral control through the direct, focal silencing of neuronal activity	30
Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis	30
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis	30
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy	30
Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury	30
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype	30
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists	29
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns	29
Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections	29
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	29
Boosting glycolysis to combat fragile bone in type 1 diabetes	29
Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment	28
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates	28
Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite	28
Induced proximity in biology and therapeutics	28

No acetyl-CoA keeps Plasmodium at bay	28
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons	27
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	27
Plant synthetic genomics: Big lessons from the little yeast	27
Screening in serum-derived medium reveals differential response to compounds targeting metabolism	27
PCNA degradation exhibits superior pharmacological effects over stoichiometric inhibition	27
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury	27
Mo’ m1A, mo’ problems	27
Structural basis of CD97 activation and G-protein coupling	26
Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity	26
Small molecule targeting of transcription-replication conflict for selective chemotherapy	26
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex	25
Meet the authors: Mitchel L. Tepe and Huiqing Zhou	25
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators	25
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors	25
Discovery of a PROTAC degrader for METTL3-METTL14 complex	25
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10	25
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death	25
RNATACs: Multispecific small molecules targeting RNA by induced proximity	24
D-aring to explore: New approaches to gasdermin D targeting	24
Mechanisms and functions of lysosomal lipid homeostasis	24
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers	24
Mapping the residue specificities of epigenome enzymes by yeast surface display	24
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate	24
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin	24
Fragment-linking peptide design yields a high-affinity ligand for microtubule-based transport	24
The physiological and pathological roles of RNA modifications in T cells	23
Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells	23
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	23
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor	23
Targeting allostery in the Dynein motor domain with small molecule inhibitors	23
How to kill an ERKsome target: PROTACs deliver the deathblow	23
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells	22
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	22
Identifying and antagonizing the interactions between layilin and glycosylated collagens	22
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	22
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	22
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	22
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	22
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	22
Bioorthogonal dissection of the replicase assembly of hepatitis C virus	22
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	22
Targeting selective E3 ligase for healing cardiac fibrosis	21
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer	21
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	21
Voices: Challenges and opportunities for bioorthogonal chemistry	21
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology	21
Break Away: FKBP12 sequestration as a target for increasing BMP activity	21
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	21
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay	21
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors	20
Excited to see you: New imaging approaches to detect ferrous iron in vivo	20
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	20
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling	20
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	19
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	19
Host-like conditions validate nutrient transport as an antimalarial drug target	19
PARP trapping is governed by the PARP inhibitor dissociation rate constant	19
The chemistry of electrical signaling in sodium channels from bacteria and beyond	19
Inhibiting GLUTtony in cancer	19
The dark side of circular RNA, a new driver of genome instability	19
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	19
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	19
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells	19
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	18
MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors	18
Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway	18
Phosphorylation barcodes direct biased chemokine signaling at CXCR3	18
Quinoline-based compounds can inhibit diverse enzymes that act on DNA	18
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	18
Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells	18
The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage	18
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model	17
Small-molecule allosteric inhibitors of GPX4	17
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells	17
Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch	17
Targeted degradation of CDK9 potently disrupts the MYC-regulated network	17
A “light” touch on PI3K to interrogate cancer drug resistance	17
Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors	17
One-pot trimodal mapping of unmethylated, hydroxymethylated, and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci	17

The culinary chemist: Out of the lab and into the tent	17
Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity	17
METTL3: Melting the tumor microenvironment for improved immunotherapy	17
Ligand discovery by activity-based protein profiling	17
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120	17
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy	17
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells	17
Strategies of bacterial detection by inflammasomes	17
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation	16
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1	16
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss	16
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation	16
A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation	16
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells	16
Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response	16
Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors	16
Ligand-directed bias of G protein signaling at the dopamine D2 receptor	16
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir	16
Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity	16
Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics	16
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation	16
A collection of chemical biology strategies for visualization in live cells	16
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy	16
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened	16
A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite	16
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis	16
Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1	16
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system	16
STX-bpc: “Brightening” the path to neuronal inhibition	16
TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor	15
Chemical genomics reveals targetable programs of human cancers rooted in pluripotency	15
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	15
A method for the detection and enrichment of endogenous cereblon substrates	15
Recognition of the tRNA structure: Everything everywhere but not all at once	15
Target protein localization and its impact on PROTAC-mediated degradation	15
Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib	15
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents	15
Robust antitumor treatment driven by lock-and-key biorecognition of dynamic cyclic diselenide-guided chiral prodrug self-assembly	15
Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states	15
The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation	15
One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade	15
Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers	15
Repurposing AS1411 for constructing ANM-PROTACs	15
Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes	14
Regulation of bacterial gene expression by non-coding RNA: It is all about time!	14
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction	14
Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release	14
Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism	14
Chemical approaches to unraveling the biology of mycobacteria	14
Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library	14
Discovery of compounds that reactivate p53 mutants in vitro and in vivo	14
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase	14
Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria	14
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis	14
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux	14
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells	14
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates	14
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface	14
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis	13
Structural and mechanistic investigations of protein S-glycosyltransferases	13
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome	13
Metabolic modulation of mitochondrial mass during CD4+ T cell activation	13
Context-dependent regulation of ferroptosis sensitivity	13
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA	13
Degrading the signal amplifier: ITK as a target for targeted protein degradation	13
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	13
Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation	13
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics	13
RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition	12
ND3 Cys39 in complex I is exposed during mitochondrial respiration	12
A sticky situation for targeted cancer therapy	12
Meet the authors: Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, and Nieng Yan	12
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	12
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function	12
Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved	12
Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions	12
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules	12
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells	12
Generation of glycan-specific nanobodies	12
Localization matters in targeted protein degradation	12
Chemical proteomics to study metabolism, a reductionist approach applied at the systems level	12
When CDK4/6i meets GPX4i: Stop dividing to die iron hard	12
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4QTY-Fc as a molecular trap	11
Cell-selective bioorthogonal labeling	11
Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency	11
Investigating the NRAS 5′ UTR as a target for small molecules	11
Raf protomers: Drug binding preferences in living cells	11
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates	11
Site-resolved assessment of targeted protein degradation	11
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus	11
Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase	11
Targeting biomolecular condensates: The rise of engineered chaperones	11
Pantothenate kinase is an effective target for antifungal therapy	11
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria	11
Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage	11