Cell Chemical Biology

Article	Citations
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	176
Antisense-mediated senseful regulation of orchestrated metabolic response	143
New sheriff in town: Cyclic peptide inhibitors of a DUB module	134
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	113
2′-OH as a universal handle for studying intracellular RNAs	95
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	93
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	91
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples	91
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	76
A versatile residue numbering scheme for Nav and Cav channels	75
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	68
Voices: Challenges and opportunities in regulating the immune system	64
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	62
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	60
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	59
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	59
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	59
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	59
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	58
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites	57
Next steps for targeted protein degradation	56
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	52
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	52
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	52
A fine-tuned azobenzene for enhanced photopharmacology in vivo	51

A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	51
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	50
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	50
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	50
A synthetic RNA-based biosensor for fructose-1,6-bisphosphate that reports glycolytic flux	48
Catalytic spike antibodies: A new paradigm in neutralization	47
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation	46
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	46
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	46
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	45
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	45
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	45
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets	44
The role of reversible and irreversible covalent chemistry in targeted protein degradation	44
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	41
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	41
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET	41
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	40
Pharmacological management of disease by overcoming structural adversity	39
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death	39
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	39
The art of designed coiled-coils for the regulation of mammalian cells	39
A double whammy for KEAP1	38
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	38
An antitubercular prodrug leaves Mycobacterium tuberculosis facing a difficult choice, poisoning or starvation?	38
Meet the authors: Aayushi Uberoi and Elizabeth A. Grice	37
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype	37
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns	37
Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis	37
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome	37
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy	36
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists	35
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	35
Enabling inclusion and looking ahead	35
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs	34
Bifunctional modalities for repurposing protein function	34
A new chink in cancer’s armor: Unleashing cell death by selective PP5 inhibition	34
Behavioral control through the direct, focal silencing of neuronal activity	34
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets	33
Bioreporters for direct mode of action-informed screening of antibiotic producer strains	33
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants	32
A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases	32
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	31
N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis	31
Shipworm symbiosis ecology-guided discovery of an antibiotic that kills colistin-resistant Acinetobacter	30
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation	30
Screening in serum-derived medium reveals differential response to compounds targeting metabolism	29
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	29
Boosting glycolysis to combat fragile bone in type 1 diabetes	29
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis	29

Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite	28
No acetyl-CoA keeps Plasmodium at bay	28
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates	28
Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment	28
Induced proximity in biology and therapeutics	27
Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections	27
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury	27
Structural basis of CD97 activation and G-protein coupling	26
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	26
D-aring to explore: New approaches to gasdermin D targeting	26
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin	26
PCNA degradation exhibits superior pharmacological effects over stoichiometric inhibition	26
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons	26
Mapping the residue specificities of epigenome enzymes by yeast surface display	26
Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity	26
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors	26
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10	26
Mo’ m1A, mo’ problems	26
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial	26
Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells	25
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex	25
Plant synthetic genomics: Big lessons from the little yeast	25
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate	25
Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria	25
Fragment-linking peptide design yields a high-affinity ligand for microtubule-based transport	25
RNATACs: Multispecific small molecules targeting RNA by induced proximity	24
Small molecule targeting of transcription-replication conflict for selective chemotherapy	24
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches	24
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators	24
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers	24
Mechanisms and functions of lysosomal lipid homeostasis	24
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death	24
Targeting allostery in the Dynein motor domain with small molecule inhibitors	23
Bioorthogonal dissection of the replicase assembly of hepatitis C virus	23
How to kill an ERKsome target: PROTACs deliver the deathblow	23
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor	23
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	23
HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells	23
Discovery of a PROTAC degrader for METTL3-METTL14 complex	23
Restoring two tumor suppressor pathways with one PAWI	23
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells	22
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	22
The physiological and pathological roles of RNA modifications in T cells	22
Identifying and antagonizing the interactions between layilin and glycosylated collagens	22
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	22
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	22
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	22
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	21
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	21
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	21
Advances and opportunities in targeted protein degradation	21
Excited to see you: New imaging approaches to detect ferrous iron in vivo	20
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling	20
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	20
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	20
Break Away: FKBP12 sequestration as a target for increasing BMP activity	20
Targeting selective E3 ligase for healing cardiac fibrosis	19
The chemistry of electrical signaling in sodium channels from bacteria and beyond	19
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	19
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	19
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology	19
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors	19
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay	19
PARP trapping is governed by the PARP inhibitor dissociation rate constant	19
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	19
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	19
Voices: Challenges and opportunities for bioorthogonal chemistry	19
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	19
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	19
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer	19
Quinoline-based compounds can inhibit diverse enzymes that act on DNA	18
Inhibiting GLUTtony in cancer	18
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	18
The dark side of circular RNA, a new driver of genome instability	18
The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage	18
How do you mend inactive tumor suppressor mutants? You glue them!	18
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model	18
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	18
Small-molecule allosteric inhibitors of GPX4	17
Ligand discovery by activity-based protein profiling	17

Phosphorylation barcodes direct biased chemokine signaling at CXCR3	17
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120	17
Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors	17
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells	17
Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors	17
Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells	17
One-pot trimodal mapping of unmethylated, hydroxymethylated, and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci	17
Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway	17
MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors	17
Strategies of bacterial detection by inflammasomes	16
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy	16
Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity	16
Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch	16
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells	16
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells	16
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir	16
Plug and play with recombinant antibody fragments	16
Targeted degradation of CDK9 potently disrupts the MYC-regulated network	16
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation	16
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1	16
A “light” touch on PI3K to interrogate cancer drug resistance	16
The culinary chemist: Out of the lab and into the tent	16
METTL3: Melting the tumor microenvironment for improved immunotherapy	16
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened	16
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy	16
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	15
A collection of chemical biology strategies for visualization in live cells	15
Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib	15
Getting stressed over topoisomerase I poisons	15
A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite	15
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents	15
Ubiquitin ligases in cancer: Functions and clinical potentials	15
Ligand-directed bias of G protein signaling at the dopamine D2 receptor	15
STX-bpc: “Brightening” the path to neuronal inhibition	15
Repurposing AS1411 for constructing ANM-PROTACs	14
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis	14
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss	14
One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade	14
Recognition of the tRNA structure: Everything everywhere but not all at once	14
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system	14
TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor	14
Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response	14
A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation	14
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation	14
Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1	14
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation	14
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	14
The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation	13
Target protein localization and its impact on PROTAC-mediated degradation	13
Chemical approaches to unraveling the biology of mycobacteria	13
Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria	13
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase	13
Discovery of compounds that reactivate p53 mutants in vitro and in vivo	13
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis	13
Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation	13
Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity	13
Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine γ-lyase (CSE) represses trophoblast syncytialization	13
Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics	13
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface	13
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux	13
Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer	13
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells	13
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth	13
Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states	13
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells	13
Chemical genomics reveals targetable programs of human cancers rooted in pluripotency	13
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis	13
Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release	13
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction	13
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function	12
Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library	12
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates	12
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	12
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA	12
ND3 Cys39 in complex I is exposed during mitochondrial respiration	12
Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved	12
Context-dependent regulation of ferroptosis sensitivity	12
Regulation of bacterial gene expression by non-coding RNA: It is all about time!	12
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells	12
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	12
Generation of glycan-specific nanobodies	12
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates	12
Degrading the signal amplifier: ITK as a target for targeted protein degradation	12
Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes	12
Metabolic modulation of mitochondrial mass during CD4+ T cell activation	12
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics	12
Structural and mechanistic investigations of protein S-glycosyltransferases	12
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome	12
A sticky situation for targeted cancer therapy	11
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus	11
Raf protomers: Drug binding preferences in living cells	11
TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer	11
Meet the authors: Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, and Nieng Yan	11
Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions	11
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules	11