Cell Chemical Biology

Article	Citations
Autophagy-Dependent Ferroptosis: Machinery and Regulation	380
PROTACs: An Emerging Therapeutic Modality in Precision Medicine	240
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis	212
The Chemistry and Biology of Ferroptosis	197
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis	141
Ferroptosis and Necroptosis in the Kidney	134
Targeted protein degradation: A promise for undruggable proteins	112
The Chemical Biology of Ferroptosis in the Central Nervous System	106
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells	96
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	92
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	84
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300	78
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	77
The Chemical Biology of Reversible Lysine Post-translational Modifications	76
Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit	71
Recent advances in identifying protein targets in drug discovery	67
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC	66
Selenium: Tracing Another Essential Element of Ferroptotic Cell Death	64
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	64
Chemical Tools for Endogenous Protein Labeling and Profiling	63
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells	61
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology	61
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	60
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	59
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis	58

Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases	56
Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming	56
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics	55
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP	55
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity	55
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	54
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders	51
The role of reversible and irreversible covalent chemistry in targeted protein degradation	50
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements	48
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	47
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	46
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	46
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors	44
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity	44
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton	43
Lanthanide-Based Optical Probes of Biological Systems	42
Context-dependent regulation of ferroptosis sensitivity	41
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System	40
How to untie G-quadruplex knots and why?	40
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases	40
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System	40
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins	40
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes	39
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	39
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2	38
The proteasome and its role in the nervous system	37
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A	37
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention	37
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants	37
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	37
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway	37
Nuisance compounds in cellular assays	37
Systematic Chemogenetic Library Assembly	36
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth	36
Morphological profiling of small molecules	36
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors	35
Optical control of targeted protein degradation	34
A fine-tuned azobenzene for enhanced photopharmacology in vivo	34
Ubiquitin ligases in cancer: Functions and clinical potentials	33
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses	33
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches	32
Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3	32
Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy	32
A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast	32
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis	31
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation	31
Decoding the messaging of the ubiquitin system using chemical and protein probes	31
Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies	30
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells	29
Exploring the target scope of KEAP1 E3 ligase-based PROTACs	28

Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth	28
Quantitative Imaging of Labile Zn2+ in the Golgi Apparatus Using a Localizable Small-Molecule Fluorescent Probe	28
Targeted In Situ Protein Diversification and Intra-organelle Validation in Mammalian Cells	28
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering	27
DogCatcher allows loop-friendly protein-protein ligation	27
Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1	27
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity	26
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death	26
Small molecule targeting of biologically relevant RNA tertiary and quaternary structures	26
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors	26
High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need	26
SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference	26
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase	26
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	25
Chemical Biology Tools for Examining the Bacterial Cell Wall	25
Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification	25
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy	25
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A	25
Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia	25
Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence	25
Polynuclear Ruthenium Amines Inhibit K2P Channels via a “Finger in the Dam” Mechanism	25
Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth	24
The chemical tools for imaging dopamine release	24
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein	24
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	24
Inhibition of Nonfunctional Ras	23
ND3 Cys39 in complex I is exposed during mitochondrial respiration	23
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex	23
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	23
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	22
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex	22
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin	22
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals	22
Mechanism of Cell Penetration by Permeabilization of Late Endosomes: Interplay between a Multivalent TAT Peptide and Bis(monoacylglycero)phosphate	22
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	22
Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds	22
The future of phenotypic drug discovery	22
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology	22
Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome	21
A photo-cross-linking GlcNAc analog enables covalent capture of N-linked glycoprotein-binding partners on the cell surface	21
Bifunctional modalities for repurposing protein function	21
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems	21
Human iPSC modeling of heart disease for drug development	21
An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity	21
Selective Modulation of Dynamic Protein Complexes	21
Chemoproteomic-enabled phenotypic screening	21
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor	21
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism	21
Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine γ-lyase (CSE) represses trophoblast syncytialization	20
Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins	20
Engineering DNA-Templated Nonribosomal Peptide Synthesis	20
Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity	20
Small-molecule allosteric inhibitors of GPX4	20
A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin	20
Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel	20
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA	20
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality	20
Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies	20
A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks	19
Piperlongumine conjugates induce targeted protein degradation	19
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions	19
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation	19
Selective autophagy as the basis of autophagy-based degraders	19
TK216 targets microtubules in Ewing sarcoma cells	19
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis	19
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	18
Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket	18
Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I	18
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis	18
Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer	18
Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion	18
A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases	18
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1	18
Identification and validation of selective deubiquitinase inhibitors	18
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing	18
Target protein localization and its impact on PROTAC-mediated degradation	18
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors	18
Making the cut with protease engineering	18
Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities	17
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity	17

Identification of a PCSK9-LDLR disruptor peptide with in vivo function	17
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling	17
Periplasmic expression of SpyTagged antibody fragments enables rapid modular antibody assembly	17
Peptide-Based PROTAC: The Predator of Pathological Proteins	17
Re-defining synthetic lethality by phenotypic profiling for precision oncology	17
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator	17
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	17
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement	17
Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex	17
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors	17
Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells	17
Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells	17
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	16
Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation	16
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	16
A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity	16
Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches	16
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader	16
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190	16
Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds	16
Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs	16
Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors	15
Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex	15
A synthetic RNA-based biosensor for fructose-1,6-bisphosphate that reports glycolytic flux	15
Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7	15
Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates	15
Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism	15
Photocontrol of Endogenous Glycine Receptors In Vivo	15
Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors	15
A PROTAC targets splicing factor 3B1	15
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers	15
Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides	15
Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators	14
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells	14
From Young to Old: AMPylation Hits the Brain	14
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I	14
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum	14
The Orphan Nuclear Receptor TLX Is a Receptor for Synthetic and Natural Retinoids	14
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis	14
Shipworm symbiosis ecology-guided discovery of an antibiotic that kills colistin-resistant Acinetobacter	14
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation	14
Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression	14
Ligand-directed bias of G protein signaling at the dopamine D2 receptor	14
Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival	14
Cytidine acetylation yields a hypoinflammatory synthetic messenger RNA	14
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome	14
Development of red genetically encoded biosensor for visualization of intracellular glucose dynamics	13
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	13
A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form	13
Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells	13
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy	13
Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer	13
Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma	13
Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade	13
Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling	13
Potent macrocycle inhibitors of the human SAGA deubiquitinating module	13
A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome	13
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury	13
A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite	13
Evolution of kinase polypharmacology across HSP90 drug discovery	12
Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6	12
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype	12
Taming transcription factors with TRAFTACs	12
Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells	12
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance	12
Discovery of compounds that reactivate p53 mutants in vitro and in vivo	12
The rise of degrader drugs	12
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics	12
Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms	12
Naturally occurring three-way junctions can be repurposed as genetically encoded RNA-based sensors	12
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus	12
Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design	12
Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment	12
Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor	12
Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition	12
DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages	12
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE	12
Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage	11
Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11	11
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial	11
Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone	11
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	11
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	11
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	11
Avoid the trap: Targeting PARP1 beyond human malignancy	11
Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling	11
Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex	11
Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones	11
Rapid in vitro prototyping of O-methyltransferases for pathway applications in Escherichia coli	11
Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors	11
The role of SERPIN citrullination in thrombosis	11
SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET	11
An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance	11
Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome	11
Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants	11