OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Chemical Biology is 39. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Targeted protein degradation: A promise for undruggable proteins	137
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	112
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells	111
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	107
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300	105
Recent advances in identifying protein targets in drug discovery	89
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	88
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC	80
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	75
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	75
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP	71
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	69
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	67
The role of reversible and irreversible covalent chemistry in targeted protein degradation	66
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	66
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics	65
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases	65
How to untie G-quadruplex knots and why?	56
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	54
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention	53
Context-dependent regulation of ferroptosis sensitivity	52
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors	51
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	50
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants	48
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	48

Morphological profiling of small molecules	48
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton	48
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins	48
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy	47
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	47
The proteasome and its role in the nervous system	45
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A	45
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	44
A fine-tuned azobenzene for enhanced photopharmacology in vivo	43
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway	42
Nuisance compounds in cellular assays	41
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth	41
DogCatcher allows loop-friendly protein-protein ligation	40
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses	39
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation	39