OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Chemical Biology is 40. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
30th anniversary celebrations: Inspiring innovation in biology and medicine	171
Covalent targeting of splicing in T cells	137
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	129
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway	128
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	121
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	107
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	93
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	89
The physiological and pathological roles of RNA modifications in T cells	89
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	88
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader	85
Host specific sphingomyelin is critical for replication of diverse RNA viruses	75
Engineered protein-small molecule conjugates empower selective enzyme inhibition	73
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	67
New sheriff in town: Cyclic peptide inhibitors of a DUB module	65
Antisense-mediated senseful regulation of orchestrated metabolic response	60
Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID	59
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	57
Next steps for targeted protein degradation	55
Generation of glycan-specific nanobodies	55
Shining light on reprogramming Tregs for cancer therapy	55
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays	54
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	54
Advances and opportunities in targeted protein degradation	54
A versatile residue numbering scheme for Nav and Cav channels	53

Degrading the signal amplifier: ITK as a target for targeted protein degradation	51
Carolyn Bertozzi: Building new bonds between molecules, fields, and communities	51
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	50
A transcriptional relationship with a natural product disrupts mitochondrial biogenesis	50
Voices: Challenges and opportunities in regulating the immune system	48
Multi-protein complexes as drug targets	48
Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions	47
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	47
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	46
Structural and mechanistic investigations of protein S-glycosyltransferases	46
How to kill an ERKsome target: PROTACs deliver the deathblow	45
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin	45
Help! I need a WNT antibody. Help! Not just any antibody	44
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis	43
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	43
Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons	40
Bioorthogonal dissection of the replicase assembly of hepatitis C virus	40