OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Chemical Biology is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Autophagy-Dependent Ferroptosis: Machinery and Regulation	380
PROTACs: An Emerging Therapeutic Modality in Precision Medicine	240
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis	212
The Chemistry and Biology of Ferroptosis	197
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis	141
Ferroptosis and Necroptosis in the Kidney	134
Targeted protein degradation: A promise for undruggable proteins	112
The Chemical Biology of Ferroptosis in the Central Nervous System	106
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells	96
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	92
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	84
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300	78
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	77
The Chemical Biology of Reversible Lysine Post-translational Modifications	76
Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit	71
Recent advances in identifying protein targets in drug discovery	67
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC	66
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	64
Selenium: Tracing Another Essential Element of Ferroptotic Cell Death	64
Chemical Tools for Endogenous Protein Labeling and Profiling	63
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology	61
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells	61
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	60
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	59
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis	58

Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming	56
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases	56
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity	55
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics	55
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP	55
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	54
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders	51
The role of reversible and irreversible covalent chemistry in targeted protein degradation	50
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements	48
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	47
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	46
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	46
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors	44
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity	44
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton	43
Lanthanide-Based Optical Probes of Biological Systems	42
Context-dependent regulation of ferroptosis sensitivity	41