OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Systems is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Approaching deconvolution with Fermi’s mindset	274
Evaluation of Peterson et al.: MAPK cascades don’t work in silos: MAP3K cross-activation of MAPKs and the effect of crosstalk on cellular responses	183
Statistical modeling and analysis of cell counts from multiplexed imaging data	143
Decoding the role of the arginine dihydrolase pathway in shaping human gut community assembly and health-relevant metabolites	124
Leveraging attention-based deep multiple instance and multiple task learning for improved neoepitope identification	111
A digital CRISPR-dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals	107
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics	106
A framework for ultra-low-input spatial tissue proteomics	94
Pitfalls of genotyping microbial communities with rapidly growing genome collections	91
Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess epitranscriptome plasticity in a neuronal cell line	83
Engineering functional materials through bacteria-assisted living grafting	82
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?	82
Integrative, high-resolution analysis of single-cell gene expression across experimental conditions with PARAFAC2-RISE	78
Localization of signaling receptors maximizes cellular information acquisition in spatially structured natural environments	77
Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition	76
What are the current bottlenecks in developing and applying CRISPR technologies?	76
Evolutionary paths that link orthogonal pairs of binding proteins	72
Design, mutate, screen: Multiplexed creation and arrayed screening of synchronized genetic clocks	71
Brain dynamics supported by a hierarchy of complex correlation patterns defining a robust functional architecture	71
Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning	65
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation	65
Homeostasis	64
What differentiates a stress response from responsiveness in general?	63
The structure of the human cell cycle	62
The geometry of cell fate	61

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation	56
Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks	54
Causal gene regulatory analysis with RNA velocity reveals an interplay between slow and fast transcription factors	53
Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease	52
How can concepts from ecology enable insights about cellular communities?	50
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation	49
Modeling elucidates context dependence in adipose regulation	48
Evaluating predictive patterns of antigen-specific B cells by single-cell transcriptome and antibody repertoire sequencing	47
The structure is the message: Preserving experimental context through tensor decomposition	43
The metallome and the biological periodic table: A metal atlas in cells	41
Mapping combinatorial expression perturbations to growth in Escherichia coli	41
The electrostatic landscape of MHC-peptide binding revealed using inception networks	40
Redesign of an Escherichia coli Nissle treatment for phenylketonuria using insulated genomic landing pads and genetic circuits to reduce burden	39
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration	38