OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Systems is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Decoding the role of the arginine dihydrolase pathway in shaping human gut community assembly and health-relevant metabolites	299
Leveraging attention-based deep multiple instance and multiple task learning for improved neoepitope identification	156
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics	132
Pitfalls of genotyping microbial communities with rapidly growing genome collections	118
Approaching deconvolution with Fermi’s mindset	111
Evaluation of Peterson et al.: MAPK cascades don’t work in silos: MAP3K cross-activation of MAPKs and the effect of crosstalk on cellular responses	109
A digital CRISPR-dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals	104
Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess epitranscriptome plasticity in a neuronal cell line	93
Engineering functional materials through bacteria-assisted living grafting	88
Statistical modeling and analysis of cell counts from multiplexed imaging data	87
A framework for ultra-low-input spatial tissue proteomics	84
What are the current bottlenecks in developing and applying CRISPR technologies?	83
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?	81
Brain dynamics supported by a hierarchy of complex correlation patterns defining a robust functional architecture	79
Evolutionary paths that link orthogonal pairs of binding proteins	76
Design, mutate, screen: Multiplexed creation and arrayed screening of synchronized genetic clocks	69
Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition	69
Localization of signaling receptors maximizes cellular information acquisition in spatially structured natural environments	68
Integrative, high-resolution analysis of single-cell gene expression across experimental conditions with PARAFAC2-RISE	67
Diclofenac and acetaminophen dim the acute-phase response but amplify expression of the iron regulator hepcidin in liver cancer cells	59
Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning	54
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation	54
What differentiates a stress response from responsiveness in general?	53
The structure of the human cell cycle	53
The geometry of cell fate	52

Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks	52
Causal gene regulatory analysis with RNA velocity reveals an interplay between slow and fast transcription factors	46
How can concepts from ecology enable insights about cellular communities?	43
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation	42
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation	42
Evaluating predictive patterns of antigen-specific B cells by single-cell transcriptome and antibody repertoire sequencing	41
Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease	41
The electrostatic landscape of MHC-peptide binding revealed using inception networks	40
Modeling elucidates context dependence in adipose regulation	39
The metallome and the biological periodic table: A metal atlas in cells	39
The structure is the message: Preserving experimental context through tensor decomposition	37
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration	37
Mapping combinatorial expression perturbations to growth in Escherichia coli	37