OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Systems is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Evaluation of Peterson et al.: MAPK cascades don’t work in silos: MAP3K cross-activation of MAPKs and the effect of crosstalk on cellular responses	343
A digital CRISPR-dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals	221
Approaching deconvolution with Fermi’s mindset	176
Seeds of their own destruction: Dominant-negative peptide screening yields functional insight and therapeutic leads	159
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics	155
Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess epitranscriptome plasticity in a neuronal cell line	154
Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma	110
A framework for ultra-low-input spatial tissue proteomics	96
Pitfalls of genotyping microbial communities with rapidly growing genome collections	95
Engineering functional materials through bacteria-assisted living grafting	95
Which image-based phenotypes are most promising for using AI to understand cellular functions and why?	94
Brain dynamics supported by a hierarchy of complex correlation patterns defining a robust functional architecture	93
Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning	93
Evolutionary paths that link orthogonal pairs of binding proteins	83
What are the current bottlenecks in developing and applying CRISPR technologies?	83
Localization of signaling receptors maximizes cellular information acquisition in spatially structured natural environments	82
Design, mutate, screen: Multiplexed creation and arrayed screening of synchronized genetic clocks	80
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?	77
Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition	69
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation	66
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation	66
Homeostasis	64
What differentiates a stress response from responsiveness in general?	62
The structure of the human cell cycle	62
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation	59

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease	58
Causal gene regulatory analysis with RNA velocity reveals an interplay between slow and fast transcription factors	57
A forecast for large-scale, predictive biology: Lessons from meteorology	57
How can concepts from ecology enable insights about cellular communities?	57
Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks	56
The geometry of cell fate	56
Mapping the multiscale structure of biological systems	56
Schrödinger’s What Is Life? at 75	55
Modeling elucidates context dependence in adipose regulation	54
Evaluating predictive patterns of antigen-specific B cells by single-cell transcriptome and antibody repertoire sequencing	54
Conservation of metabolic regulation by phosphorylation and non-covalent small-molecule interactions	53
The structure is the message: Preserving experimental context through tensor decomposition	53
The electrostatic landscape of MHC-peptide binding revealed using inception networks	51
Mapping combinatorial expression perturbations to growth in Escherichia coli	51
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors	49
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions	47
Global transcription regulation revealed from dynamical correlations in time-resolved single-cell RNA sequencing	47
Redesign of an Escherichia coli Nissle treatment for phenylketonuria using insulated genomic landing pads and genetic circuits to reduce burden	44
Deciphering tumor ecosystems at super resolution from spatial transcriptomics with TESLA	43