npj Precision Oncology

Papers
(The median citation count of npj Precision Oncology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Patient-derived organoids as a predictive biomarker for treatment response in cancer patients140
Genomic context of NTRK1/2/3 fusion-positive tumours from a large real-world population96
High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients71
Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty66
PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma64
Microbiome dysbiosis in lung cancer: from composition to therapy64
Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance61
Quantitative MRI-based radiomics for noninvasively predicting molecular subtypes and survival in glioma patients61
Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity60
Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy56
The pan-cancer landscape of crosstalk between epithelial-mesenchymal transition and immune evasion relevant to prognosis and immunotherapy response50
GD2 CAR T cells against human glioblastoma50
Genetic mutation and biological pathway prediction based on whole slide images in breast carcinoma using deep learning47
Will polygenic risk scores for cancer ever be clinically useful?43
Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors42
Survival improvement for patients with metastatic colorectal cancer over twenty years40
Clinical application of a lung cancer organoid (tumoroid) culture system40
Antibody-drug conjugates in lung cancer: dawn of a new era?40
Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes38
Structural variant detection in cancer genomes: computational challenges and perspectives for precision oncology38
Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer37
Identification of gastric cancer subtypes based on pathway clustering36
Deep learning for end-to-end kidney cancer diagnosis on multi-phase abdominal computed tomography35
The L730V/I RET roof mutations display different activities toward pralsetinib and selpercatinib34
Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance34
Targeting CDK1 in cancer: mechanisms and implications33
A phase I/II study of rovalpituzumab tesirine in delta-like 3—expressing advanced solid tumors33
Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)33
Dynamic roles of inflammasomes in inflammatory tumor microenvironment33
High TGF-β signature predicts immunotherapy resistance in gynecologic cancer patients treated with immune checkpoint inhibition33
A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients32
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer32
Immunosuppression for immune-related adverse events during checkpoint inhibition: an intricate balance31
Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer30
Artificial intelligence reveals features associated with breast cancer neoadjuvant chemotherapy responses from multi-stain histopathologic images29
Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma29
Self-supervised attention-based deep learning for pan-cancer mutation prediction from histopathology29
Just Add Data: automated predictive modeling for knowledge discovery and feature selection29
Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer29
Predictive and prognostic transcriptomic biomarkers in soft tissue sarcomas28
Co-occurring genomic alterations and immunotherapy efficacy in NSCLC27
Cell graph neural networks enable the precise prediction of patient survival in gastric cancer27
A blood-based miRNA signature with prognostic value for overall survival in advanced stage non-small cell lung cancer treated with immunotherapy27
Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies27
Validation of a liquid biopsy assay with molecular and clinical profiling of circulating tumor DNA26
Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes26
Pan-cancer prognostic genetic mutations and clinicopathological factors associated with survival outcomes: a systematic review26
Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy25
Impressive response to dabrafenib, trametinib, and osimertinib in a metastatic EGFR-mutant/BRAF V600E lung adenocarcinoma patient25
Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome24
Single-cell spatial architectures associated with clinical outcome in head and neck squamous cell carcinoma24
Prostate cancer polygenic risk score and prediction of lethal prostate cancer24
Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma24
Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients24
Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury23
Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis23
Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patients23
Pre-treatment serum albumin and mutational burden as biomarkers of response to immune checkpoint blockade22
A genomic mutation signature predicts the clinical outcomes of immunotherapy and characterizes immunophenotypes in gastrointestinal cancer22
Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets21
Deep learning for diagnosis of acute promyelocytic leukemia via recognition of genomically imprinted morphologic features20
A deep learning model for molecular label transfer that enables cancer cell identification from histopathology images20
Combined FGFR and Akt pathway inhibition abrogates growth of FGFR1 overexpressing EGFR-TKI-resistant NSCLC cells20
Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition20
Usability of deep learning and H&E images predict disease outcome-emerging tool to optimize clinical trials20
A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer20
Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors19
Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer19
Characterizing advanced breast cancer heterogeneity and treatment resistance through serial biopsies and comprehensive analytics19
Genomic features and tumor immune microenvironment alteration in NSCLC treated with neoadjuvant PD-1 blockade19
Deep learning generates synthetic cancer histology for explainability and education19
Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma19
Small extracellular vesicle PD-L1 in cancer: the knowns and unknowns19
Spatially variant immune infiltration scoring in human cancer tissues19
Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis19
Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor19
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia19
Genomic landscape of 891 RET fusions detected across diverse solid tumor types18
Artificial intelligence in ovarian cancer histopathology: a systematic review18
Harnessing the immunotherapeutic potential of CDK4/6 inhibitors in melanoma: is timing everything?18
A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada18
Imaging immunity in patients with cancer using positron emission tomography18
Crizotinib in patients with tumors harboring ALK or ROS1 rearrangements in the NCI-MATCH trial18
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations17
Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs17
Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance17
Circulating tumor cell copy-number heterogeneity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors17
Precision medicine: affording the successes of science17
An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma17
Inflation of tumor mutation burden by tumor-only sequencing in under-represented groups17
Real-world data analyses unveiled the immune-related adverse effects of immune checkpoint inhibitors across cancer types17
Co-targeting CDK2 and CDK4/6 overcomes resistance to aromatase and CDK4/6 inhibitors in ER+ breast cancer16
Favorable immune checkpoint inhibitor outcome of patients with melanoma and NSCLC harboring FAT1 mutations16
Genomic characterization and outcome evaluation of kinome fusions in lung cancer revealed novel druggable fusions16
Rare deleterious germline variants and risk of lung cancer16
The Aurora kinase/β-catenin axis contributes to dexamethasone resistance in leukemia16
A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures16
HER3 activation contributes toward the emergence of ALK inhibitor-tolerant cells in ALK-rearranged lung cancer with mesenchymal features16
Artificial intelligence for the next generation of precision oncology16
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia16
Impact of TP53 mutations in Triple Negative Breast Cancer15
Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND115
Multiscale-omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target15
Pentraxin 3 is a stromally-derived biomarker for detection of pancreatic ductal adenocarcinoma15
On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer15
A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial15
MatchMiner: an open-source platform for cancer precision medicine15
Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer case15
Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM15
PALB2 or BARD1 loss confers homologous recombination deficiency and PARP inhibitor sensitivity in prostate cancer15
Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis15
Racial and ethnic disparities in a real-world precision oncology data registry15
Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer15
Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes14
Integrated molecular characterisation of endometrioid ovarian carcinoma identifies opportunities for stratification14
Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies14
New regulatory thinking is needed for AI-based personalised drug and cell therapies in precision oncology14
Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia14
First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound14
Artificial intelligence in neuro-oncology: advances and challenges in brain tumor diagnosis, prognosis, and precision treatment14
Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy13
Computer extracted gland features from H&E predicts prostate cancer recurrence comparably to a genomic companion diagnostic test: a large multi-site study13
Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer13
ALK fusions in the pan-cancer setting: another tumor-agnostic target?13
Adaptive resistance to lorlatinib via EGFR signaling in ALK-rearranged lung cancer13
Collision of germline POLE and PMS2 variants in a young patient treated with immune checkpoint inhibitors13
Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer13
Precision medicine: preliminary results from the Initiative for Molecular Profiling and Advanced Cancer Therapy 2 (IMPACT2) study13
Overcoming resistance to BRAFV600E inhibition in melanoma by deciphering and targeting personalized protein network alterations13
Extraordinary clinical response to ibrutinib in low-grade ovarian cancer guided by organoid drug testing13
Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium13
Characterization of evolution trajectory and immune profiling of brain metastasis in lung adenocarcinoma13
Tumor-associated macrophage-related strategies for glioma immunotherapy13
Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration13
Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients13
Molecular characterization of low-grade serous ovarian carcinoma identifies genomic aberrations according to hormone receptor expression13
Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma12
Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition12
Prediction of early-stage melanoma recurrence using clinical and histopathologic features12
Deep computational image analysis of immune cell niches reveals treatment-specific outcome associations in lung cancer12
Deletions on 9p21 are associated with worse outcomes after anti-PD-1/PD-L1 monotherapy but not chemoimmunotherapy12
Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics12
Advances in NK cell therapy for brain tumors12
Models that combine transcriptomic with spatial protein information exceed the predictive value for either single modality12
PARP inhibitors promote stromal fibroblast activation by enhancing CCL5 autocrine signaling in ovarian cancer12
Patient-level proteomic network prediction by explainable artificial intelligence12
Radiomics for characterization of the glioma immune microenvironment12
Epigenomics and immunotherapeutic advances in pediatric brain tumors12
Preoperative clinical and tumor genomic features associated with pathologic lymph node metastasis in clinical stage I and II lung adenocarcinoma12
Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity12
A DNA methylation-based liquid biopsy for triple-negative breast cancer12
DNA-based copy number analysis confirms genomic evolution of PDX models12
Genomic investigation of co-targeting tumor immune microenvironment and immune checkpoints in pan-cancer immunotherapy11
Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients11
Combination venetoclax and selinexor effective in relapsed refractory multiple myeloma with translocation t(11;14)11
Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation11
Integrated molecular and clinical analysis of BRAF-mutant glioma in adults11
Swiss-PO: a new tool to analyze the impact of mutations on protein three-dimensional structures for precision oncology11
Comprehensive RNA analysis of CSF reveals a role for CEACAM6 in lung cancer leptomeningeal metastases11
BAP1 methylation: a prognostic marker of uveal melanoma metastasis11
Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD34-positive cells in the chronic phase of primary myelofibrosis11
Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction11
Multi-site desmoplastic small round cell tumors are genetically related and immune-cold11
Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients11
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells10
Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer10
ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework10
MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression10
Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma10
A multi-omics study links TNS3 and SEPT7 to long-term former smoking NSCLC survival10
Benefits of local consolidative treatment in oligometastases of solid cancers: a stepwise-hierarchical pooled analysis and systematic review10
Comprehensive molecular profiling of pulmonary pleomorphic carcinoma10
Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements10
A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment10
Refined high-content imaging-based phenotypic drug screening in zebrafish xenografts10
Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma10
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation9
Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication9
STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis9
Comparative biomarker analysis of PALOMA-2/3 trials for palbociclib9
AKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers9
PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system9
Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity9
The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer9
Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy9
HER3 targeting augments the efficacy of panobinostat in claudin-low triple-negative breast cancer cells8
Clinical prospects of WRN inhibition as a treatment for MSI tumours8
All models are wrong and yours are useless: making clinical prediction models impactful for patients8
An appraisal of genetic testing for prostate cancer susceptibility8
ESCCAL-1 promotes cell-cycle progression by interacting with and stabilizing galectin-1 in esophageal squamous cell carcinoma8
Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition8
Potential pathogenic germline variant reporting from tumor comprehensive genomic profiling complements classic approaches to germline testing8
ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression8
Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies8
TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study8
Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers8
Rewiring of the N-Glycome with prostate cancer progression and therapy resistance8
Panels and models for accurate prediction of tumor mutation burden in tumor samples8
Single-cell atlas of diverse immune populations in the advanced biliary tract cancer microenvironment8
A single-cell based precision medicine approach using glioblastoma patient-specific models8
SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas8
Drivers of genomic loss of heterozygosity in leiomyosarcoma are distinct from carcinomas8
A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT38
Peripheral blood DNA methylation profiles predict future development of B-cell Non-Hodgkin Lymphoma8
Radiological artificial intelligence - predicting personalized immunotherapy outcomes in lung cancer8
Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma8
Evolution of acquired resistance in a ROS1+ KRAS G12C+ NSCLC through the MAPK pathway7
Are sex and gender considered in head and neck cancer clinical studies?7
Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature7
GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer7
Locoregional tumor burden and risk of mortality in metastatic breast cancer7
Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling7
An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading7
Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies7
PERK mediates resistance to BRAF inhibition in melanoma with impaired PTEN7
Challenges and opportunities associated with the MD Anderson IMPACT2 randomized study in precision oncology7
Determinants of response to CDK4/6 inhibitors in the real-world setting7
Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers7
Complete response to alectinib in ALK-fusion metastatic salivary ductal carcinoma7
Genetic program activity delineates risk, relapse, and therapy responsiveness in multiple myeloma7
Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy7
Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer7
Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade7
MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression7
Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors7
The regulatory role of cancer stem cell marker gene CXCR4 in the growth and metastasis of gastric cancer7
Large language models and multimodal foundation models for precision oncology7
BRAF v600E–mutant cancers treated with vemurafenib alone or in combination with everolimus, sorafenib, or crizotinib or with paclitaxel and carboplatin (VEM-PLUS) study7
Optimizing cancer immunotherapy response prediction by tumor aneuploidy score and fraction of copy number alterations6
Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma6
Polygenic risk scores to stratify cancer screening should predict mortality not incidence6
Prognostic Mutational Signatures of NSCLC Patients treated with chemotherapy, immunotherapy and chemoimmunotherapy6
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy6
Landscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profiling6
Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers6
Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy6
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment6
The tumor mutational landscape of BRCA2-deficient primary and metastatic prostate cancer6
PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127+ and KLRG1+ CD8 T cells6
Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance6
Proximity of immune and tumor cells underlies response to BRAF/MEK-targeted therapies in metastatic melanoma patients6
Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology6
High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival6
Multi-omics analysis reveals NNMT as a master metabolic regulator of metastasis in esophageal squamous cell carcinoma6
Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer5
HRD effects on first-line adjuvant chemotherapy and PARPi maintenance therapy in Chinese ovarian cancer patients5
Scientific figures interpreted by ChatGPT: strengths in plot recognition and limits in color perception5
Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP5
Pan-cancer molecular tumor board experience with biomarker-driven precision immunotherapy5
Evolution of MET and NRAS gene amplification as acquired resistance mechanisms in EGFR mutant NSCLC5
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