Open Life Sciences

Article	Citations
Probiotic management and inflammatory factors as a novel treatment in cirrhosis: A systematic review and meta-analysis	45
Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction	24
Berberine suppressed sarcopenia insulin resistance through SIRT1-mediated mitophagy	22
A transcriptomic evaluation of the mechanism of programmed cell death of the replaceable bud in Chinese chestnut	20
Biofertilizer and NPSB fertilizer application effects on nodulation and productivity of common bean (Phaseolus vulgaris L.) at Sodo Zuria, Southern Ethiopia	20
Prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer	19
Antitumor activity of RUNX3: Upregulation of E-cadherin and downregulation of the epithelial–mesenchymal transition in clear-cell renal cell carcinoma	18
Exopolysaccharides from Pseudomonas tolaasii inhibit the growth of Pleurotus ostreatus mycelia	15
Impact of fracture fixation surgery on cognitive function and the gut microbiota in mice with a history of stroke	14
Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species	14
Changes in blood glucose and metabolism in hyperuricemia mice	13
IL-11 promotes Ang II-induced autophagy inhibition and mitochondrial dysfunction in atrial fibroblasts	13
An unusual ectopic thymoma clonal evolution analysis: A case report	12
Radiotherapy for primary thyroid adenoid cystic carcinoma	11
Severe cumulative skin toxicity during toripalimab combined with vemurafenib following toripalimab alone	11
Design and functional preliminary investigation of recombinant antigen EgG1Y162–EgG1Y162 against Echinococcus granulosus	10
Dietary food additive monosodium glutamate with or without high-lipid diet induces spleen anomaly: A mechanistic approach on rat model	10
Screening of the best time window for MSC transplantation to treat acute myocardial infarction with SDF-1α antibody-loaded targeted ultrasonic microbubbles: An in vivo study in miniswine	10
High glucose and high lipid induced mitochondrial dysfunction in JEG-3 cells through oxidative stress	10
CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review	10
Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments	9
Diagnostic value of serum neuroactive substances in the acute exacerbation of chronic obstructive pulmonary disease complicated with depression	9
Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway	9
PTTG1 induces pancreatic cancer cell proliferation and promotes aerobic glycolysis by regulating c-myc	8
Identification of KDM4C as a gene conferring drug resistance in multiple myeloma	8

Knockdown of SETD5 inhibited glycolysis and tumor growth in gastric cancer cells by down-regulating Akt signaling pathway	8
Role of cerebellar cortex in associative learning and memory in guinea pigs	8
Comparison of axon extension: PTFE versus PLA formed by a 3D printer	7
Comparing the differences of prokaryotic microbial community between pit walls and bottom from Chinese liquor revealed by 16S rRNA gene sequencing	7
Current state of research on copper complexes in the treatment of breast cancer	7
Lung nodule segmentation via semi-residual multi-resolution neural networks	7
TNF-α and IL-8 levels are positively correlated with hypobaric hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats	7
Effect of long-term in-row branch covering on soil microorganisms in pear orchards	7
The effect of NK cell therapy on sepsis secondary to lung cancer: A case report	7
Characterization of rabbit polyclonal antibody against camel recombinant nanobodies	7
Investigation into the association of FNDC1 and ADAMTS12 gene expression with plumage coloration in Muscovy ducks	7
From slides to insights: Harnessing deep learning for prognostic survival prediction in human colorectal cancer histology	6
Effects of physical exercise on biomarkers of oxidative stress in healthy subjects: A meta-analysis of randomized controlled trials	6
PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications	6
Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia	6
Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders	6
Rehabilitation effect of intelligent rehabilitation training system on hemiplegic limb spasms after stroke	6
Aquaporin-8 overexpression is involved in vascular structure and function changes in placentas of gestational diabetes mellitus patients	5
Genome-wide identification and characterization of NBS-encoding genes in the sweet potato wild ancestor Ipomoea trifida (H.B.K.)	5
Simultaneous triple primary malignancies, including bladder cancer, lymphoma, and lung cancer, in an elderly male: A case report	5
Bmi-1 directly upregulates glucose transporter 1 in human gastric adenocarcinoma	5
Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method	5
Combination of a bronchogenic cyst in the thoracic spinal canal with chronic myelocytic leukemia	5
Preparation and evaluation of LA-PEG-SPION, a targeted MRI contrast agent for liver cancer	5
The entire chloroplast genome sequence of Asparagus setaceus (Kunth) Jessop: Genome structure, gene composition, and phylogenetic analysis in Asparagaceae	5
In silico and in vivo analysis of TIPE1 expression in diffuse large B cell lymphoma	5
Case report: Quadruple primary malignant neoplasms including esophageal, ureteral, and lung in an elderly male	5
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway	5
Optimised feature selection-driven convolutional neural network using gray level co-occurrence matrix for detection of cervical cancer	5
BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis	5
Report on a case of liver-originating malignant melanoma of unknown primary	5
Crown and diameter structure of purePinus massonianaLamb. forest in Hunan province, China	5
Constitutive and evoked release of ATP in adult mouse olfactory epithelium	5
Bioinformatics network analyses of growth differentiation factor 11	5
Research on meat quality of Qianhua Mutton Merino sheep and Small-tail Han sheep	5
Regulation of miR-30b in cancer development, apoptosis, and drug resistance	5
Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy	5
Effects of cadmium on the synthesis of active ingredients in Salvia miltiorrhiza	5
Predictive analytics in smart healthcare for child mortality prediction using a machine learning approach	4
Application of metagenomic next-generation sequencing technology in the etiological diagnosis of peritoneal dialysis-associated peritonitis	4
Systematic evaluation of clinical efficacy of CYP1B1 gene polymorphism in EGFR mutant non-small cell lung cancer observed by medical image	4
Coexistence of hereditary spherocytosis with SPTB P.Trp1150 gene variant and Gilbert syndrome: A case report and literature review	4
LL37-mtDNA regulates viability, apoptosis, inflammation, and autophagy in lipopolysaccharide-treated RLE-6TN cells by targeting Hsp90aa1	4
Phytol-mixed micelles alleviate dexamethasone-induced osteoporosis in zebrafish: Activation of the MMP3–OPN–MAPK pathway-mediating bone remodeling	4
Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites	4
6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress	4
Application of metagenomic next-generation sequencing in the diagnosis of pathogens in patients with diabetes complicated by community-acquired pneumonia	4
Water, nitrogen, and phosphorus coupling improves gray jujube fruit quality and yield	4
Study on the mechanism of inhibiting patulin production by fengycin	4
Association of interleukin-10 rs1800896, rs1800872, and interleukin-6 rs1800795 polymorphisms with squamous cell carcinoma risk: A meta-analysis	4

Research progress of serum eosinophil in chronic obstructive pulmonary disease and asthma	4
Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats	4
SOX4 promotes high-glucose-induced inflammation and angiogenesis of retinal endothelial cells by activating NF-κB signaling pathway	4
Dosimetry comparison with helical tomotherapy, volumetric modulated arc therapy, and intensity-modulated radiotherapy for grade II gliomas: A single‑institution case series	4
HP1 induces ferroptosis of renal tubular epithelial cells through NRF2 pathway in diabetic nephropathy	4
Reexamination of Aspergillus cristatus phylogeny in dark tea: Characteristics of the mitochondrial genome	4
Advances in diagnosis and treatment of perimenopausal syndrome	4
An overview of the production and use of Bacillus thuringiensis toxin	4
PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway	4
Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy	4
Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook	3
Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis	3
A case report of diagnosis and dynamic monitoring of Listeria monocytogenes meningitis with NGS	3
Isolation, identification, and drug resistance of a partially isolated bacterium from the gill of Siniperca chuatsi	3
Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2	3
The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology	3
Identification of rice leaf diseases and deficiency disorders using a novel DeepBatch technique	3
Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro	3
Selection and functional identification of Dof genes expressed in response to nitrogen in Populus simonii × Populus nigra	3
Effects of organic materials on soil bacterial community structure in long-term continuous cropping of tomato in greenhouse	3
Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms	3
Protein Z modulates the metastasis of lung adenocarcinoma cells	3
Calcifying nanoparticles initiate the calcification process of mesenchymal stem cells in vitro through the activation of the TGF-β1/Smad signaling pathway and promote the decay of echinococcosi	3
Effects of heavy metals on bacterial community surrounding Bijiashan mining area located in northwest China	3
Association of ADRB2 gene polymorphisms and intestinal microbiota in Chinese Han adolescents	3
Cloning and prokaryotic expression of WRKY48 from Caragana intermedia	3
Novel risk prediction models for deep vein thrombosis after thoracotomy and thoracoscopic lung cancer resections, involving coagulation and immune function	3
Microbial diversity of milk ghee in southern Gansu and its effect on the formation of ghee flavor compounds	3
Investigating the impact of wet rendering (solventless method) on PUFA-rich oil from catfish (Clarias magur) viscera	3
Yak meat content in feed and its impact on the growth of rats	3
Discovery of exercise-related genes and pathway analysis based on comparative genomes of Mongolian originated Abaga and Wushen horse	3
Effect of selenium and methods of protein extraction on the proteomic profile of Saccharomyces yeast	3
Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice	3
Clinical analysis of severe Chlamydia psittaci pneumonia: Case series study	3
Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice	3
Clinical characteristics and the prognosis of diabetic foot in Tibet: A single center, retrospective study	3
The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC	3
Surgery, adjuvant immunotherapy plus chemotherapy and radiotherapy for primary malignant melanoma of the parotid gland (PGMM): A case report	3
IL-33/soluble ST2 axis is associated with radiation-induced cardiac injury	3
Renal microangiopathy and immune complex glomerulonephritis induced by anti-tumour agents: A case report	3
Genome-wide identification and expression analysis of CPP-like gene family in Triticum aestivum L. under different hormone and stress conditions	3
Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure	3
Medical imaging in rheumatoid arthritis: A review on deep learning approach	3
Characterization of intestinal microbiota and serum metabolites in patients with mild hepatic encephalopathy	3
Screening of different growth conditions of Bacillus subtilis isolated from membrane-less microbial fuel cell toward antimicrobial activity profiling	2
ctDNA as a prognostic biomarker in resectable CLM: Systematic review and meta-analysis	2
Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms	2
Sorafenib inhibits ovarian cancer cell proliferation and mobility and induces radiosensitivity by targeting the tumor cell epithelial–mesenchymal transition	2
Quercetin inhibits cytotoxicity of PC12 cells induced by amyloid-beta 25–35 via stimulating estrogen receptor α, activating ERK1/2, and inhibiting apoptosis	2
Influence of MTHFR polymorphism, alone or in combination with smoking and alcohol consumption, on cancer susceptibility	2
Physical activity enhances fecal lactobacilli in rats chronically drinking sweetened cola beverage	2
Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells	2
Nasopharyngeal tuberculosis: A case report	2
Identification of metabolic genes for the prediction of prognosis and tumor microenvironment infiltration in early-stage non-small cell lung cancer	2
Favorable response to surufatinib in a patient with necrolytic migratory erythema: A case report	2
Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway	2
Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury	2
Potential biomarkers and molecular mechanisms in preeclampsia progression	2
Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells	2
Association between TGF-β1 and β-catenin expression in the vaginal wall of patients with pelvic organ prolapse	2
Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control	2
Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis	2
Experimental study on the optimization of ANM33 release in foam cells	2
Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice	2
Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm	2
Circular RNAs as potential biomarkers for male severe sepsis	2
N6-Methyladenosine-related alternative splicing events play a role in bladder cancer	2
Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C	2
Characterization of the structural, oxidative, and immunological features of testis tissue from Zucker diabetic fatty rats	2
Antibacterial, antifungal, and phytochemical properties of Salsola kali ethanolic extract	2
Value of brain injury-related indicators based on neural network in the diagnosis of neonatal hypoxic-ischemic encephalopathy	2
Selection and validation of reference genes for RT-qPCR analysis of different organs at various development stages in Caragana intermedia	2
Monosodium iodoacetate-induced subchondral bone microstructure and inflammatory changes in an animal model of osteoarthritis	2
Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China	2
Effects of NM23 transfection of human gastric carcinoma cells in mice	2
Clinical value of macrogenome next-generation sequencing on infections	2
Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection	2
Babesia microti-induced fulminant sepsis in an immunocompromised host: A case report and the case-specific literature review	2
Development and validation of a predictive model for immune-related genes in patients with tongue squamous cell carcinoma	2
Disruption of BCAA degradation is a critical characteristic of diabetic cardiomyopathy revealed by integrated transcriptome and metabolome analysis	2

The relationship between TMCO1 and CALR in the pathological characteristics of prostate cancer and its effect on the metastasis of prostate cancer cells	2
Preliminary screening of microplastic contamination in different marine fish species of Taif market, Saudi Arabia	2
Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke	2
Fertilizer application parameters for drip-irrigated peanut based on the fertilizer effect function established from a “3414” field trial	2
Gut microbiota changes associated with low-carbohydrate diet intervention for obesity	2
Identification of winter wheat pests and diseases based on improved convolutional neural network	2
Knockdown of G1P3 inhibits cell proliferation and enhances the cytotoxicity of dexamethasone in acute lymphoblastic leukemia	2
A novel SLC8A1-ALK fusion in lung adenocarcinoma confers sensitivity to alectinib: A case report	2
The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review	2
A missense variant in NCF1 is associated with susceptibility to unexplained recurrent spontaneous abortion	2
Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells	2
Small breast epithelial mucin as a useful prognostic marker for breast cancer patients	2
Metastasis from small cell lung cancer to ovary: A case report	2
Metagenomic next-generation sequencing in diagnosing Pneumocystis jirovecii pneumonia: A case report	2
Rutin–chitooligosaccharide complex: Comprehensive evaluation of its anti-inflammatory and analgesic properties in vitro and in vivo	2
Emerging patterns in nanoparticle-based therapeutic approaches for rheumatoid arthritis: A comprehensive bibliometric and visual analysis spanning two decades	2
Mucormycosis co-infection in COVID-19 patients: An update	2
Oral nifedipine and phytosterol, intravenous nicardipine, and oral nifedipine only: Three-arm, retrospective, cohort study for management of severe preeclampsia	2
A study of forensic genetics: ITO index distribution and kinship judgment between two individuals	2
Effects of plant density on alfalfa (Medicago sativa L.) seed yield in western Heilongjiang areas	2
On correlation between canopy vegetation and growth indexes of maize varieties with different nitrogen efficiencies	2
Knockdown of HCK promotes HREC cell viability and inner blood–retinal barrier integrity by regulating the AMPK signaling pathway	2
Relationship between platelet activation markers and spontaneous abortion: A meta-analysis	2
Distribution of CYP2D6 and CYP2C19 gene polymorphisms in Han and Uygur populations with breast cancer in Xinjiang, China	2
Meta-analysis on the efficacy of allogeneic hematopoietic stem cell transplantation to treat malignant lymphoma	2
The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype	2
Cystic adenomyoma of the uterus: Case report and literature review	2
Erratum to “Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study”	2
A novel GNAS mutation in pseudohypoparathyroidism type 1a with articular flexion deformity: A case report	2
Untargeted metabolomics reveals sour jujube kernel benefiting the nutritional value and flavor of Morchella esculenta	2
Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress	2