Open Life Sciences

Article	Citations
Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method	64
PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway	50
Combination of a bronchogenic cyst in the thoracic spinal canal with chronic myelocytic leukemia	38
Identification of KDM4C as a gene conferring drug resistance in multiple myeloma	33
Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders	33
LL37-mtDNA regulates viability, apoptosis, inflammation, and autophagy in lipopolysaccharide-treated RLE-6TN cells by targeting Hsp90aa1	33
An unusual ectopic thymoma clonal evolution analysis: A case report	32
Study on the tissue-specific distribution of triterpenoid saponins in Panax japonicus var. major based on	26
Real-world validation of ECOG performance status and neutrophil-to-lymphocyte ratio in second-line paclitaxel plus ramucirumab for advanced gastric cancer	25
Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms	25
The protective role of whole grains and legumes against gastric cancer	22
Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy	22
Predictive analytics in smart healthcare for child mortality prediction using a machine learning approach	21
Application of CRISPR/Cas gene editing for infectious disease control in poultry	21
Comparing the differences of prokaryotic microbial community between pit walls and bottom from Chinese liquor revealed by 16S rRNA gene sequencing	21
Immunological responses of septic rats to combination therapy with thymosin α1 and vitamin C	20
Hesperidin and its zinc(ii) complex enhance osteoblast differentiation and bone formation: In vitro and in vivo	18
Association between TGF-β1 and β-catenin expression in the vaginal wall of patients with pelvic organ prolapse	18
Primary pulmonary synovial sarcoma in the bronchial cavity: A case report	18
Hyperosmolar hyperglycemic state with severe hypernatremia coexisting with central diabetes insipidus: A case report and literature review	17
Effects of NM23 transfection of human gastric carcinoma cells in mice	17
Isolation, identification, and drug resistance of a partially isolated bacterium from the gill of Siniperca chuatsi	16
Protein Z modulates the metastasis of lung adenocarcinoma cells	16
Liupao tea aqueous extract alleviates dextran sulfate sodium-induced ulcerative colitis in rats by modulating the gut microbiota	16
Metastasis from small cell lung cancer to ovary: A case report	15

ErbB4 promotes M2 activation of macrophages in idiopathic pulmonary fibrosis	14
UC-MSCs exhibit superior antifibrotic and anti-inflammatory effects compared to BM-MSCs in a bleomycin-induced idiopathic pulmonary fibrosis model	14
A case report of diagnosis and dynamic monitoring of Listeria monocytogenes meningitis with NGS	14
Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2	14
Trade-offs in survival strategies: root trait differentiation of trees and shrubs on the Jingpo Lake lava platform	13
Fluorescent detection of sialic acid–binding lectins using functionalized quantum dots in ELISA format	13
Effect of periostin on bone metabolic and autophagy factors during tooth eruption in mice	13
Molecular identification and control studies on Coridius sp. (Hemiptera: Dinidoridae) in Al-Khamra, south of Jeddah, Saudi Arabia	13
Gastric-protective and antioxidant effects of fermented Pichia pastoris residue hydrolyzed peptides on alcohol-treated mice	13
Hairpin in a haystack : In silico identification and characterization of plant-conserved microRNA in Rafflesiaceae	13
Association of ADRB2 gene polymorphisms and intestinal microbiota in Chinese Han adolescents	12
Oral nifedipine and phytosterol, intravenous nicardipine, and oral nifedipine only: Three-arm, retrospective, cohort study for management of severe preeclampsia	12
Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection	12
Norepinephrine promotes lung cancer cell progression via PFKFB3-promoted histone lactylation-mediated activation of the NF-κB signaling pathway	12
Small breast epithelial mucin as a useful prognostic marker for breast cancer patients	12
Knockdown of USP7 alleviates atherosclerosis in ApoE-deficient mice by regulating EZH2 expression	12
Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke	11
Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis	11
Optimization of the chicken manure to corn straw ratio and assessment of bacterial diversity during composting	11
Clusterin activates the heat shock response via the PI3K/Akt pathway to protect cardiomyocytes from high-temperature-induced apoptosis	11
Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control	11
Incidence of different pressure patterns of spinal cerebellar ataxia and analysis of imaging and genetic diagnosis	10
A case of Trousseau syndrome: Screening, detection and complication	10
Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique	10
Adiponectin improves clozapine-induced lipid accumulation and inflammation without affecting insulin resistance	10
Long non-coding RNAs in bone formation: Key regulators and therapeutic prospects	10
Bamboo charcoal affects soil properties and bacterial community in tea plantations	10
A biomedical decision support system for meta-analysis of bilateral upper-limb training in stroke patients with hemiplegia	10
Significant elevated CXCL14 and decreased IL-39 levels in patients with tuberculosis	10
Current research and evidence gaps on placental development in iron deficiency anemia	10
Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics	9
The potential role of rutin, a flavonoid, in the management of cancer through modulation of cell signaling pathways	9
Retraction to “Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats”	9
Longitudinal monitoring of autoantibody dynamics in patients with early-stage non-small-cell lung cancer undergoing surgery	9
Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis	9
The G protein-coupled receptor-related gene signatures for predicting prognosis and immunotherapy response in bladder urothelial carcinoma	9
A case of bloodstream infection caused by Neisseria gonorrhoeae	9
Haplo-hematopoietic stem cell transplantation and immunoradiotherapy for severe aplastic anemia complicated with nasopharyngeal carcinoma: A case report	9
Optimization of eco-friendly ultrasonic probe-assisted extraction from Stevia rebaudiana Bertoni using response surface methodology and antioxidant evalu	9
Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy	9
Concomitant gastric carcinoma and primary hepatic angiosarcoma in a patient: A case report	9
Influence of solvent-free extraction of fish oil from catfish (Clarias magur) heads using a Taguchi orthogonal array design: A qualitative and quantitative approach	8
Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model	8
Case report of atypical undernutrition of hypoproteinemia type	8
DEC1 regulates osteoblast proliferation and differentiation via the RUNX2 signaling pathway	8
Cadmium toxicity, health risk and its remediation using low-cost biochar adsorbents	8
Comparison of immunotherapy combined with stereotactic radiotherapy and targeted therapy for patients with brain metastases: A systemic review and meta-analysis	8
Sepsis complicated by haemophagocytic lymphohistiocytosis triggered by methicillin-resistant Staphylococcus aureus and human herpesvirus 8 in an immunoco	8
Zinc oxide nanoparticles enable sustainable disease management in tea by dual nutrient and antifungal action	8
Correlation analysis between semen routine parameters and sperm DNA fragmentation index in patients with semen non-liquefaction: A retrospective study	8

Effects of mixed salinity and alkali stress on photosynthetic characteristics and PEPC gene expression of vegetable soybean seedlings	8
Chlorate-induced molecular floral transition revealed by transcriptomes	8
A bibliometric analysis of Moringa oleifera during 2000–2024	8
Phylogenetic analysis of promoter regions of human Dolichol kinase (DOLK) and orthologous genes using bioinformatics tools	8
Atractylenolide I alleviates the experimental allergic response in mice by suppressing TLR4/NF-kB/NLRP3 signalling	8
Exploring the diagnostic markers of essential tremor: A study based on machine learning algorithms	7
Inflammation-related signaling pathways in tendinopathy	7
Quantitative immunohistochemistry analysis of breast Ki67 based on artificial intelligence	7
Differences in the flavonoid composition of the leaves, fruits, and branches of mulberry are distinguished based on a plant metabolomics approach	7
Comparative efficiency and residue levels of spraying programs against powdery mildew in grape varieties	7
15-Lipoxygenase-2 deficiency induces foam cell formation that can be restored by salidroside through the inhibition of arachidonic acid effects	7
Comprehensive phytochemical and toxicological analysis of Chenopodium ambrosioides (L.) fractions	7
Effect of berrycactus fruit (Myrtillocactus geometrizans) on glutamate, glutamine, and GABA levels in the frontal cortex of rats fed with a high-fat diet	7
Effects of maternal calcium and protein intake on the development and bone metabolism of offspring mice	7
Novel compound heterozygous mutations in TELO2 in an infant with You-Hoover-Fong syndrome: A case report and literature review	7
Advances in cancer immunotherapy and future directions in personalized medicine	7
The dilemma of food genetics and improvement	7
Case of nasopharyngeal tuberculosis complicated with cervical lymph node and pulmonary tuberculosis	7
Effects and potential mechanisms of luteolin on cisplatin mediated inhibition of cervical adenocarcinoma	7
KRT16 and APOA1: key regulators of proliferation and lipid metabolism in non-small cell lung cancer	7
Retraction to “A data mining technique for detecting malignant mesothelioma cancer using multiple regression analysis”	6
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway	6
Novel cuproptosis-related genes C1QBP and PFKP identified as prognostic and therapeutic targets in lung ad	6
Review on role of honey in disease prevention and treatment through modulation of biological activities	6
Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs	6
Analysis of bacterial community structure of Fuzhuan tea with different processing techniques	6
Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation	6
A case report of lymphoplasmacytic lymphoma with spherocytosis	6
Phytochemicals of Roman chamomile: Antioxidant, anti-aging, and whitening activities of distillation residues	6
Construction of pectinase gene engineering microbe and its application in tobacco sheets	6
The expression of epidermal growth factor receptor 2 and its relationship with tumor-infiltrating lymphocytes and clinical pathological features in breast cancer patients	6
Exploring antioxidant strategies in the pathogenesis of ALS	6
Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI	6
Effects of luteolin on proliferation and apoptosis of breast cancer cells by regulating EGFR/STAT3/AKt pathway	6
Long-term administration of morphine specifically alters the level of protein expression in different brain regions and affects the redox state	6
Neutrophilia with subclinical Cushing’s disease: A case report and literature review	6
Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches	6
Clinical and pathological analysis of pulmonary epithelioid vascular endothelial tumor	6
Downregulation of RIP3 ameliorates the left ventricular mechanics and function after myocardial infarctionviamodulating NF-κB/NLRP3 pathway	6
Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation sequencing: A case report	6
Novel rare genetic variants of familial and sporadic pulmonary atresia identified by whole-exome sequencing	6
Effects of Piriformospora indica and arbuscular mycorrhizal fungus on growth and physiology of Moringa oleifera	6
FOXQ1–FGF10 axis attenuates inflammation in human dental pulp stem cells by suppressing NF-κB signaling	6
Identification of iron metabolism-related genes as diagnostic signatures in sepsis by blood transcriptomic analysis	6
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior	6
Collagen changes in rabbit conjunctiva after conjunctival crosslinking	6
Diversity and environmental drivers of Suillus communities in Pinus sylvestris var.	6
Overexpression of HE4/WFDC2 gene in mice leads to keratitis and corneal opacity	6
The role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes	6
The role of HDAC11 in age-related hearing loss: Mechanisms and therapeutic implications	5
Uterine tumor resembling ovarian sex cord tumor with extensive rhabdoid differentiation: A case report	5
Association between PAX9 or MSX1 gene polymorphism and tooth agenesis risk: A meta-analysis	5
Effect of long-term in-row branch covering on soil microorganisms in pear orchards	5
Reexamination of Aspergillus cristatus phylogeny in dark tea: Characteristics of the mitochondrial genome	5
Macrofungal sporocarp community in the lichen Scots pine forests	5
The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy	5
Comparison of nutritional value of the wild and cultivated spiny loaches at three growth stages	5
Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways	5
Corrigendum to “Utilization of convolutional neural networks to analyze microscopic images for high-throughput screening of mesenchymal stem cells”	5
Alpha-1-antichymotrypsin: a potential inducer for epithelial-mesenchymal transition in lupus nephritis	5
Detection of Deltamethrin resistance level and association between sodium channel domain III gene mutation sites and drug resistance of Rhipicephalus microplus	5
Analgesic and toxicological evaluation of cannabidiol-rich Moroccan Cannabis sativa L. (Khardala variety) extract: Evidence from an <	5
Severe cumulative skin toxicity during toripalimab combined with vemurafenib following toripalimab alone	5
Crown and diameter structure of purePinus massonianaLamb. forest in Hunan province, China	5
Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis	5
Non-linear associations between cardiovascular metabolic indices and metabolic-associated fatty liver disease: A cross-sectional study in the US population (2017–2020)	5
Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy	5
Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway	5
Knockdown of SHP-2 delays renal tubular epithelial cell injury in diabetic nephropathy by inhibiting NLRP3 inflammasome-mediated pyroptosis	5
Helicobacter pylori causes gastric dysbacteriosis in chronic gastritis patients	5
Alterations of metabolites related to microbiota–gut–brain axis in plasma of colon cancer, esophageal cancer, stomach cancer, and lung cancer patients	5
Neutrophil-related signature characterizes immune landscape and predicts prognosis of esophageal squamous cell carcinoma	5
Clinical pathogen profiles and lung microbiome features in lung infection patients and concurrent cancer: insights from metagenomics next-generation sequencing	5
BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis	5
Impact of SWCNT-conjugated senna leaf extract on breast cancer cells: A potential apoptotic therapeutic strategy	5
Coexistence of hereditary spherocytosis with SPTB P.Trp1150 gene variant and Gilbert syndrome: A case report and literature review	5
ZAG promotes colorectal cancer cell proliferation and epithelial–mesenchymal transition by promoting lipid synthesis	5
Integrated genomic and clinical modeling for prognostic assessment of radiotherapy response in rectal neoplasms	5
Application and teaching of computer molecular simulation embedded technology and artificial intelligence in drug research and development	5
Effects of pegylated recombinant human granulocyte colony-stimulating factor on lymphocytes and white blood cells of patients with malignant tumor	5

Pathogenic bacteria and treatment resistance in older cardiovascular disease patients with lung infection and risk prediction model	5
Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease	4
Comparative transcriptomes reveal molecular mechanisms of apple blossoms of different tolerance genotypes to chilling injury	4
Continuous non-adherent culture promotes transdifferentiation of human adipose-derived stem cells into retinal lineage	4
Novel risk prediction models for deep vein thrombosis after thoracotomy and thoracoscopic lung cancer resections, involving coagulation and immune function	4
IgG4-related disease complicated by PLA2R-associated membranous nephropathy: A case report	4
Decreased serum TIMP4 levels in patients with rheumatoid arthritis	4
Pulmonary cryptococcosis with headache as the first presentation: A case report	4
Research progress on the regulation of autophagy in cardiovascular diseases by chemokines	4
Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway	4
Surgery, adjuvant immunotherapy plus chemotherapy and radiotherapy for primary malignant melanoma of the parotid gland (PGMM): A case report	4
Experimental study on the optimization of ANM33 release in foam cells	4
Exopolysaccharides from Pseudomonas tolaasii inhibit the growth of Pleurotus ostreatus mycelia	4
IL-11 promotes Ang II-induced autophagy inhibition and mitochondrial dysfunction in atrial fibroblasts	4
Therapeutic approaches for liver fibrosis/cirrhosis by targeting pyroptosis	4
Efficacy and mechanism of escin in improving the tissue microenvironment of blood vessel walls via anti-inflammatory and anticoagulant effects: Implications for clinical practice	4
Paeoniflorin alleviates spinal cord injury in a cell model via regulating PTEN and PI3K/AKT signaling	4
The complete chloroplast genome of Gerbera piloselloides (L.) Cass., 1820 (Carduoideae, Asteraceae) and its phylogenetic analysis	4
A comparative analysis of dendrometric, macromorphological, and micromorphological characteristics of Pistacia atlantica subsp. atlantica and Pistacia terebinthus in the middle At	4
Value of brain injury-related indicators based on neural network in the diagnosis of neonatal hypoxic-ischemic encephalopathy	4
To explore the relationship between endometrial hyperemia and polycystic ovary syndrome	4
Effects of different sources of potassium fertiliser on yield, fruit quality and nutrient absorption in “ Harward ” kiwifruit ( Ac	4
Electroacupuncture on GB acupoints improves osteoporosis via the estradiol–PI3K–Akt signaling pathway	4
Merkel cell carcinoma: Clinicopathological analysis of three patients and literature review	4
Heat stroke associated with novel leukaemia inhibitory factor receptor gene variant in a Chinese infant	4
A novel GNAS mutation in pseudohypoparathyroidism type 1a with articular flexion deformity: A case report	4
Rhodococcus equiandBrucellapulmonary mass in immunocompetent: A case report and literature review	4
Biofertilizer and NPSB fertilizer application effects on nodulation and productivity of common bean (Phaseolus vulgaris L.) at Sodo Zuria, Southern Ethiopia	4
CircRNA circuits orchestrate lactate metabolism in gastrointestinal cancer progression	4
Advances in diagnosis and treatment of perimenopausal syndrome	4
Application of metagenomic next-generation sequencing technology in the etiological diagnosis of peritoneal dialysis-associated peritonitis	4
Low-molecular-weight metabolites from lactic acid bacteria suppress cervical cancer progression by inhibiting EMT via the Wnt/β-catenin pathway	4
Tumoral calcinosis complicating CKD-MBD in hemodialysis: a case report	4
PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection	4
Electroacupuncture alleviates sciatic nerve injury in sciatica rats by regulating BDNF and NGF levels, myelin sheath degradation, and autophagy	4
Evaluation of effects of small-incision approach treatment on proximal tibia fracture by deep learning algorithm-based magnetic resonance imaging	4
Neurodegenerative diseases and neuroinflammation-induced apoptosis	4
Case report: Successful bronchoscopic interventional treatment of endobronchial leiomyomas	4
Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma	4
Solitary pulmonary metastasis with cystic airspaces in colon cancer: A rare case report	4
PTX3 promotes IVIG resistance-induced endothelial injury in Kawasaki disease by regulating the NF-κB pathway	4
Effects of exogenous 2,4-epibrassinolide on photosynthetic traits of 53 cowpea varieties under NaCl stress	4
Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation	4
Causal effects of trace elements on congenital foot deformities and their subtypes: a Mendelian randomization study with gut microbiota mediation	4
B2M drives PD-1 inhibitor resistance in DLBCL through independent dual immune escape mechanisms	4
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) in children: a case report and literature review	4
Investigating the impact of wet rendering (solventless method) on PUFA-rich oil from catfish (Clarias magur) viscera	4
Exosomes from human urine-derived stem cells in porcine urethral scaffold construction	4
Mechanism of KLF4 Inhibition of epithelial-mesenchymal transition in gastric cancer cells	4