Open Life Sciences

Article	Citations
Silver nanoparticles: synthesis, characterisation and biomedical applications	149
Green fabrication of Co and Co3O4 nanoparticles and their biomedical applications: A review	87
Honey in wound healing: An updated review	62
Supplementation of probiotics in water beneficial growth performance, carcass traits, immune function, and antioxidant capacity in broiler chickens	38
Diabetes and COVID-19	30
Phytoremediation of pollutants from wastewater: A concise review	22
Research progress on the mechanism of orexin in pain regulation in different brain regions	21
Dietary food additive monosodium glutamate with or without high-lipid diet induces spleen anomaly: A mechanistic approach on rat model	16
Investigating microplastics and potentially toxic elements contamination in canned Tuna, Salmon, and Sardine fishes from Taif markets, KSA	16
An effect of positional isomerism of benzoic acid derivatives on antibacterial activity against Escherichia coli	15
A review of the current state of the computer-aided diagnosis (CAD) systems for breast cancer diagnosis	15
Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats	15
Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook	15
Recombinant Bacteroides fragilis enterotoxin-1 (rBFT-1) promotes proliferation of colorectal cancer via CCL3-related molecular pathways	15
Functional constituents of plant-based foods boost immunity against acute and chronic disorders	15
Effects of heavy metals on bacterial community surrounding Bijiashan mining area located in northwest China	14
Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma	14
LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis	14
Bacteriospermia – A formidable player in male subfertility	14
LncRNA PVT1 promotes cervical cancer progression by sponging miR-503 to upregulate ARL2 expression	13
CTRP9 protects against MIA-induced inflammation and knee cartilage damage by deactivating the MAPK/NF-κB pathway in rats with osteoarthritis	13
CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis	13
Intravenous infusion of the exosomes derived from human umbilical cord mesenchymal stem cells enhance neurological recovery after traumatic brain injury via suppressing the NF-κB pathway	13
Identification of rice leaf diseases and deficiency disorders using a novel DeepBatch technique	12
Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-β1/smad2/ROS/caspase-3 pathway	11

The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats	11
Blocking circ_UBR4 suppressed proliferation, migration, and cell cycle progression of human vascular smooth muscle cells in atherosclerosis	11
circTLK1 facilitates the proliferation and metastasis of renal cell carcinoma by regulating miR-495-3p/CBL axis	11
Abnormal methylation caused by folic acid deficiency in neural tube defects	11
CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression	11
Long noncoding RNA FTX ameliorates hydrogen peroxide-induced cardiomyocyte injury by regulating the miR-150/KLF13 axis	11
Metabolic profiling of fatty acids in Tripterygium wilfordii multiglucoside- and triptolide-induced liver-injured rats	11
Artificial intelligence and internet of things oriented sustainable precision farming: Towards modern agriculture	11
Silencing XIST mitigated lipopolysaccharide (LPS)-induced inflammatory injury in human lung fibroblast WI-38 cells through modulating miR-30b-5p/CCL16 axis and TLR4/NF-κB signaling pathway	10
Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry	10
MiR-203-3p inhibits the oxidative stress, inflammatory responses and apoptosis of mice podocytes induced by high glucose through regulating Sema3A expression	10
Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis	10
MiR-30c-5p/ROCK2 axis regulates cell proliferation, apoptosis and EMT via the PI3K/AKT signaling pathway in HG-induced HK-2 cells	10
Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development	10
Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities	10
WDR74 promotes proliferation and metastasis in colorectal cancer cells through regulating the Wnt/β-catenin signaling pathway	10
Application of exogenous auxin and gibberellin regulates the bolting of lettuce (Lactuca sativa L.)	10
Two new inflammatory markers related to the CURB-65 score for disease severity in patients with community-acquired pneumonia: The hypersensitive C-reactive protein to albumin ratio and fibrinogen to a	10
Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats	10
miR-339-3p regulated acute pancreatitis induced by caerulein through targeting TNF receptor-associated factor 3 in AR42J cells	9
Effects of organic materials on soil bacterial community structure in long-term continuous cropping of tomato in greenhouse	9
Diversity of microbiota in Slovak summer ewes’ cheese “Bryndza”	9
Clinical significance of activated Wnt/β-catenin signaling in apoptosis inhibition of oral cancer	9
Effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves	9
miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2	9
Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice	9
Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis	8
Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis	8
Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells	8
Testosterone aggravates cerebral vascular injury by reducing plasma HDL levels	8
Immunoregulation of synovial macrophages for the treatment of osteoarthritis	8
SOX4 promotes high-glucose-induced inflammation and angiogenesis of retinal endothelial cells by activating NF-κB signaling pathway	8
Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression	7
Potential prognostic markers and significant lncRNA–mRNA co-expression pairs in laryngeal squamous cell carcinoma	7
The significance of PAK4 in signaling and clinicopathology: A review	7
Effects of chemical-based fertilizer replacement with biochar-based fertilizer on albic soil nutrient content and maize yield	7
Effect of food processing on the antioxidant activity of flavones from Polygonatum odoratum (Mill.) Druce	7
Genome-wide identification of MAPK family genes and their response to abiotic stresses in tea plant (Camellia sinensis)	7
Hydroxysafflor yellow A improved retinopathy via Nrf2/HO-1 pathway in rats	7
In vitro induction and characterisation of tetraploid drumstick tree (Moringa oleifera Lam.)	7
Medical imaging in rheumatoid arthritis: A review on deep learning approach	7
FTO gene expression in diet-induced obesity is downregulated by Solanum fruit supplementation	7
Ropivacaine inhibits proliferation, migration, and invasion while inducing apoptosis of glioma cells by regulating the SNHG16/miR-424-5p axis	7
microRNA-9-5p protects liver sinusoidal endothelial cell against oxygen glucose deprivation/reperfusion injury	7
Morphological structures and histochemistry of roots and shoots in Myricaria laxiflora (Tamaricaceae)	7
Relationship between blood clots and COVID-19 vaccines: A literature review	7
Agronomic and economic performance of mung bean (Vigna radiata L.) varieties in response to rates of blended NPS fertilizer in Kindo Koysha district, Southern Ethiopia	7
Vitamin D deficiency and cardiovascular risk in type 2 diabetes population	7
Melatonin enhances salt tolerance in sorghum by modulating photosynthetic performance, osmoregulation, antioxidant defense, and ion homeostasis	7
Knockdown of TUG1 rescues cardiomyocyte hypertrophy through targeting the miR-497/MEF2C axis	7

miR-299-3p suppresses cell progression and induces apoptosis by downregulating PAX3 in gastric cancer	7
Age-related changes in peripheral T-cell subpopulations in elderly individuals: An observational study	7
NR4A1 inhibits the epithelial–mesenchymal transition of hepatic stellate cells: Involvement of TGF-β–Smad2/3/4–ZEB signaling	7
mNGS facilitates the accurate diagnosis and antibiotic treatment of suspicious critical CNS infection in real practice: A retrospective study	6
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress	6
lncRNA myocardial infarction-associated transcript (MIAT) knockdown alleviates LPS-induced chondrocytes inflammatory injury via regulating miR-488-3p/sex determining region Y-related HMG-box 11 (SOX11	6
TEAD4 is a novel independent predictor of prognosis in LGG patients with IDH mutation	6
Role of MMP-2 and CD147 in kidney fibrosis	6
Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis	6
Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis	6
Circ_WWC3 overexpression decelerates the progression of osteosarcoma by regulating miR-421/PDE7B axis	6
TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ	6
Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage	6
Identification of leaf rust resistance genesLr34andLr46in common wheat (Triticum aestivumL. ssp.aestivum) lines of different origin using multiplex PCR	6
Comparative analysis of the SPL gene family in five Rosaceae species: Fragaria vesca, Malus domestica, Prunus persica, Rubus occidentalis, and Pyrus pyrifolia	6
The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia	6
Advances in diagnosis and treatment of perimenopausal syndrome	6
IL-17 in osteoarthritis: A narrative review	6
Study on the optimal antagonistic effect of a bacterial complex against Monilinia fructicola in peach	6
Relationship between hemodynamic parameters and portal venous pressure in cirrhosis patients with portal hypertension	5
Immunoregulatory function of Dictyophora echinovolvata spore polysaccharides in immunocompromised mice induced by cyclophosphamide	5
Sorafenib inhibits ovarian cancer cell proliferation and mobility and induces radiosensitivity by targeting the tumor cell epithelial–mesenchymal transition	5
Effect of selenium and methods of protein extraction on the proteomic profile of Saccharomyces yeast	5
An advanced approach for fig leaf disease detection and classification: Leveraging image processing and enhanced support vector machine methodology	5
Composition of low-molecular-weight glutenin subunits in common wheat (Triticum aestivum L.) and their effects on the rheological properties of dough	5
Relationship of Gensini score with retinal vessel diameter and arteriovenous ratio in senile CHD	5
T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology	5
Seasonal succession of bacterial communities in cultured Caulerpa lentillifera detected by high-throughput sequencing	5
The role of erythrocytes and erythroid progenitor cells in tumors	5
3,4-Dihydroxyphenylethanol ameliorates lipopolysaccharide-induced septic cardiac injury in a murine model	5
The entire chloroplast genome sequence of Asparagus cochinchinensis and genetic comparison to Asparagus species	5
Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis	5
Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study	5
miR-378a-3p regulates glioma cell chemosensitivity to cisplatin through IGF1R	5
Preparation of konjac oligoglucomannans with different molecular weights and their in vitro and in vivo antioxidant activities	5
circ-CFH promotes the development of HCC by regulating cell proliferation, apoptosis, migration, invasion, and glycolysis through the miR-377-3p/RNF38 axis	5
Effects of Loofah cylindrica extract on learning and memory ability, brain tissue morphology, and immune function of aging mice	5
Genetic susceptibility to high myopia in Han Chinese population	5
Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis	5
circ_CHFR regulates ox-LDL-mediated cell proliferation, apoptosis, and EndoMT by miR-15a-5p/EGFR axis in human brain microvessel endothelial cells	5
Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches	5
Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers	5
Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis	5
Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function	5
Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage	5
Microbial diversity of milk ghee in southern Gansu and its effect on the formation of ghee flavor compounds	5
Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?	5
Long noncoding RNA TUG1 regulates degradation of chondrocyte extracellular matrix via miR-320c/MMP-13 axis in osteoarthritis	5
Research on meat quality of Qianhua Mutton Merino sheep and Small-tail Han sheep	5
Investigation of molecular regulation mechanism under the pathophysiology of subarachnoid hemorrhage	5
The potential for the use of leghemoglobin and plant ferritin as sources of iron	5
Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning	5
Inflammation-related signaling pathways in tendinopathy	5
Preliminary screening of microplastic contamination in different marine fish species of Taif market, Saudi Arabia	5
Effects of inorganic and organic selenium sources on the growth performance of broilers in China: A meta-analysis	4
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso	4
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway	4
Identifying two pathogenic variants in a patient with pigmented paravenous retinochoroidal atrophy	4
Biocompatibility and osteointegration capability of β-TCP manufactured by stereolithography 3D printing: In vitro study	4
Identification of novel drought-responsive miRNA regulatory network of drought stress response in common vetch (Vicia sativa)	4
Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway	4
Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions	4
Functional conservation and divergence in plant-specific GRF gene family revealed by sequences and expression analysis	4
TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats	4
Stochastic gradient descent optimisation for convolutional neural network for medical image segmentation	4
Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis	4
Isolation of microglia from retinas of chronic ocular hypertensive rats	4
Application of culture, PCR, and PacBio sequencing for determination of microbial composition of milk from subclinical mastitis dairy cows of smallholder farms	4
6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress	4
Biomedical evaluation of antioxidant properties of lamb meat enriched with iodine and selenium	4
Characterization of intestinal microbiota and serum metabolites in patients with mild hepatic encephalopathy	4
Performance comparison of three scaling algorithms in NMR-based metabolomics analysis	4
lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis	4
Microbiological transglutaminase: Biotechnological application in the food industry	4
Probiotics for inflammatory bowel disease: Is there sufficient evidence?	4
Analysis of bacterial community structure of Fuzhuan tea with different processing techniques	4
Optimization of biogas potential using kinetic models, response surface methodology, and instrumental evidence for biodegradation of tannery fleshings during anaerobic digestion	4
Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis	4
Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnanc	4
Identification of winter wheat pests and diseases based on improved convolutional neural network	4

Circ_0013359 facilitates the tumorigenicity of melanoma by regulating miR-136-5p/RAB9A axis	4
Study on the mechanism of inhibiting patulin production by fengycin	4
LINC00665 regulates hepatocellular carcinoma by modulating mRNA via the m6A enzyme	4
Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B	4
Response of benthic invertebrate assemblages to seasonal and habitat condition in the Wewe River, Ashanti region (Ghana)	4
Genome-wide identification and expression analysis of CPP-like gene family in Triticum aestivum L. under different hormone and stress conditions	4
Genetic diversity and population structure of Cinnamomum balansae Lecomte inferred by microsatellites	4
Relationship of FTO gene variations with NAFLD risk in Chinese men	4
Characterization of GMPP from Dendrobium huoshanense yielding GDP-D-mannose	4
Association study of CLDN14 variations in patients with kidney stones	4
Twig biomass allocation of Betula platyphylla in different habitats in Wudalianchi Volcano, northeast China	4
ctDNA as a prognostic biomarker in resectable CLM: Systematic review and meta-analysis	4
Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus	3
Downregulation of STOX1 is a novel prognostic biomarker for glioma patients	3
Elevated IL-35 level and iTr35 subset increase the bacterial burden and lung lesions in Mycobacterium tuberculosis-infected mice	3
MiR-146b-3p protects against AR42J cell injury in cerulein-induced acute pancreatitis model through targeting Anxa2	3
Malignant pleural effusion diagnosis and therapy	3
Comparison between voltammetric detection methods for abalone-flavoring liquid	3
Effects of miR-185-5p on replication of hepatitis C virus	3
A rare presentation of type II Abernethy malformation and nephrotic syndrome: Case report and review	3
The role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis	3
Characterization and evaluation of anti-Salmonella enteritidisactivity of indigenous probiotic lactobacilli in mice	3
SDR16C5 promotes proliferation and migration and inhibits apoptosis in pancreatic cancer	3
Immunosuppressive treatment for idiopathic membranous nephropathy: An updated network meta-analysis	3
Poly-l-lysine-caused cell adhesion induces pyroptosis in THP-1 monocytes	3
CD11b is involved in coxsackievirus B3-induced viral myocarditis in mice by inducing Th17 cells	3
Effects of growth hormone on lipid metabolism and sexual development in pubertal obese male rats	3
On correlation between canopy vegetation and growth indexes of maize varieties with different nitrogen efficiencies	3
Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report	3
A case report of diagnosis and dynamic monitoring of Listeria monocytogenes meningitis with NGS	3
Characterization of rabbit polyclonal antibody against camel recombinant nanobodies	3
The impact of sewage sludge on the fungal communities in the rhizosphere and roots of barley and on barley yield	3
Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments	3
Predators of the giant pine scale, Marchalina hellenica (Gennadius 1883; Hemiptera: Marchalinidae), out of its natural range in Turkey	3
TNF-α and IL-8 levels are positively correlated with hypobaric hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats	3
Effects of the interaction of Notch and TLR4 pathways on inflammation and heart function in septic heart	3
Interleukin-17A influences the vulnerability rather than the size of established atherosclerotic plaques in apolipoprotein E-deficient mice	3
Soy isoflavone reduces LPS-induced acute lung injury via increasing aquaporin 1 and aquaporin 5 in rats	3
Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes	3
Plant volatile organic compounds attractive to Lygus pratensis	3
Transcriptome analysis of resistance mechanism to potato wart disease	3
Crop-livestock integration practices, knowledge, and attitudes among smallholder farmers: Hedging against climate change-induced shocks in semi-arid Zimbabwe	3
Tissue culture and rapid propagation technology for Gentiana rhodantha	3
Application and teaching of computer molecular simulation embedded technology and artificial intelligence in drug research and development	3
Small cell neuroendocrine carcinoma expressing alpha fetoprotein in the endometrium	3
Exosomal HBV-DNA for diagnosis and treatment monitoring of chronic hepatitis B	3
ACTB and GAPDH appear at multiple SDS-PAGE positions, thus not suitable as reference genes for determining protein loading in techniques like Western blotting	3
Effects of irrigation and nitrogen fertilization on mitigating salt-induced Na+ toxicity and sustaining sea rice growth	3
A two-microRNA signature predicts the progression of male thyroid cancer	3
Molecular characterization and phylogenetic studies of Echinococcus granulosus and Taenia multiceps coenurus cysts in slaughtered sheep in Saudi Arabia	3
Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites	3
ADHFE1 is a correlative factor of patient survival in cancer	3
Curcumin induces apoptosis in human hepatocellular carcinoma cells by decreasing the expression of STAT3/VEGF/HIF-1α signaling	3
Selection and functional identification of Dof genes expressed in response to nitrogen in Populus simonii × Populus nigra	3
Long non-coding RNA HOXB-AS1 is a prognostic marker and promotes hepatocellular carcinoma cells’ proliferation and invasion	3
The impedance analysis of small intestine fusion by pulse source	3
Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway	3
The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss	3
A case of pulmonary embolism with bad warfarin anticoagulant effects caused by E. coli infection	3
Effects of glucose and osmotic pressure on the proliferation and cell cycle of human chorionic trophoblast cells	3
Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways	3
Potential regulatory mechanism of TNF-α/TNFR1/ANXA1 in glioma cells and its role in glioma cell proliferation	3
Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model	3
Investigation of genotype diversity of 7,804 norovirus sequences in humans and animals of China	3
Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights	3
Babesia microti-induced fulminant sepsis in an immunocompromised host: A case report and the case-specific literature review	3
Regulation of miR-30b in cancer development, apoptosis, and drug resistance	3