OOIR: Observatory of International Research

Papers

(The TQCC of Bioengineering & Translational Medicine is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Nanoparticles in the clinic: An update post COVID‐19 vaccines	193
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles	171
Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect	134
Viral vector‐based gene therapies in the clinic	130
A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy	95
Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo	87
Cell therapies in the clinic	85
Alzheimer's and Parkinson's disease therapies in the clinic	68
An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis	63
Doxorubicin‐loaded nanoparticle coated with endothelial cells‐derived exosomes for immunogenic chemotherapy of glioblastoma	59
Nanocomposite hydrogels for biomedical applications	58
(Nano)platforms in bladder cancer therapy: Challenges and opportunities	58
Temporal profiling of cytokines in passively expressed sweat for detection of infection using wearable device	50
RNA therapeutics in the clinic	49
Advanced strategies to thwart foreign body response to implantable devices	47
Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications	46
Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering	46
Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy	44
Ferrostatin‐1‐loaded liposome for treatment of corneal alkali burn via targeting ferroptosis	44
Fourth‐generation glucose sensors composed of copper nanostructures for diabetes management: A critical review	43
Mussel‐inspired biomaterials: From chemistry to clinic	41
Cell loaded hydrogel containing Ag‐doped bioactive glass–ceramic nanoparticles as skin substitute: Antibacterial properties, immune response, and scarless cutaneous wound regeneration	39
Design and clinical application of injectable hydrogels for musculoskeletal therapy	38
Polylysine for skin regeneration: A review of recent advances and future perspectives	38
Bio‐functional hydrogel with antibacterial and anti‐inflammatory dual properties to combat with burn wound infection	35

A review of biomarkers in the context of type 1 diabetes: Biological sensing for enhanced glucose control	35
Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice	34
Mitochondrial transplantation therapy inhibit carbon tetrachloride‐induced liver injury through scavenging free radicals and protecting hepatocytes	33
Adaptive multi‐degree‐of‐freedom in situ bioprinting robot for hair‐follicle‐inclusive skin repair: A preliminary study conducted in mice	30
A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing	30
Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects	29
Internet‐of‐medical‐things integrated point‐of‐care biosensing devices for infectious diseases: Toward better preparedness for futuristic pandemics	27
Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia	27
Radiation nanosensitizers in cancer therapy—From preclinical discoveries to the outcomes of early clinical trials	27
IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development	27
Nanomaterials‐based sensors for the detection of COVID‐19: A review	26
ε‐poly‐L‐lysine‐modified polydopamine nanoparticles for targeted photothermal therapy of drug‐resistant bacterial keratitis	25
Portable hand‐held bioprinters promote in situ tissue regeneration	25
An updated review of SARS‐CoV‐2 detection methods in the context of a novel coronavirus pandemic	23
Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls	23
PEGylated therapeutics in the clinic	22
Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues	22
Mesenchymal stem cell‐inspired microgel scaffolds to control macrophage polarization	22
Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podo	22
Engineered macrophage membrane‐enveloped nanomedicine for ameliorating myocardial infarction in a mouse model	22
Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes−liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer	22
Digital therapeutics in the clinic	22
Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities	21
Biomedical applications of three‐dimensional bioprinted craniofacial tissue engineering	21
Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens	21
Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells	21
Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma	20
Resolvin D1‐loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis	20
Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes	20
Integrated bioactive scaffold with aptamer‐targeted stem cell recruitment and growth factor‐induced pro‐differentiation effects for anisotropic meniscal regeneration	20
Ultra‐thin, high strength, antibiotic‐eluting sutures for prevention of ophthalmic infection	20
Potent neutralization of SARS‐CoV‐2 including variants of concern by vaccines presenting the receptor‐binding domain multivalently from nanoscaffolds	19
Micro and nanotechnologies: The little formulations that could	19
Transplantation of bioengineered Reelin‐loadedPLGA/PEGmicelles can accelerate neural tissue regeneration in photothrombotic stroke model of mouse	19
Brain‐targeted exosome‐mimetic cell membrane nanovesicles with therapeutic oligonucleotides elicit anti‐tumor effects in glioblastoma animal models	19
A bioinspired synthetic soft hydrogel for the treatment of dry eye	19
The effect of local non‐thermal plasma therapy on the cancer‐immunity cycle in a melanoma mouse model	18
Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long‐term treatment of inflammatory arthritis	18
A skin patch integrating swellable microneedles and electrochemical test strips for glucose and alcohol measurement in skin interstitial fluid	18
In‐cytoplasm mitochondrial transplantation for mesenchymal stem cells engineering and tissue regeneration	18
Enhanced tumor cell killing by ultrasound after microtubule depolymerization	18
Flourishing tumor organoids: History, emerging technology, and application	18
Graphene quantum dots‐based targeted nanoprobes detecting drug delivery, imaging, and enhanced chemotherapy of nasopharyngeal carcinoma	18
Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP‐1 and modulating gut microbiota	18
An injectable gelatin/sericin hydrogel loaded with human umbilical cord mesenchymal stem cells for the treatment of uterine injury	17
Intra‐articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis	17
Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis	17
Analysis of aqueous humor total antioxidant capacity and its correlation with corneal endothelial health	16
miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers	16
Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing	16

Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling	16
Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors	15
Validation of the 1,4‐butanediolthermoplastic polyurethane as a novel material for3Dbioprinting applications	15
Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration	15
Reactive oxygen species‐responsive mitochondria‐targeted liposomal quercetin attenuates retinal ischemia–reperfusion injury via regulating SIRT1/FOXO3A and p38 MAPK si	15
A bioprinted complex tissue model for myotendinous junction with biochemical and biophysical cues	15
A biomimetic hyaluronic acid‐silk fibroin nanofiber scaffold promoting regeneration of transected urothelium	15
E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stres	15
Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration	15
Application of photoacoustic computed tomography in biomedical imaging: A literature review	14
Photoresponsive prodrug‐dye nanoassembly for in‐situ monitorable cancer therapy	14
Application of polymersomes in membrane protein study and drug discovery: Progress, strategies, and perspectives	14
LINC00473‐modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid‐induced osteonecrosis of femoral head: A detailed mec	14
Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives	14
Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing	14
Prediction of drug permeation through microneedled skin by machine learning	14
Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids	14
Fabrication of bone‐derived decellularized extracellular matrix/ceramic‐based biocomposites and their osteo/odontogenic differentiation ability for dentin regeneration	14
Transcriptomic response of brain tissue to focused ultrasound‐mediated blood–brain barrier disruption depends strongly on anesthesia	13
Cancer vaccines in the clinic	13
3D bioprinting of an implantable xeno‐free vascularized human skin graft	13
Sprayable tissue adhesive with biodegradation tuned for prevention of postoperative abdominal adhesions	13
Polysaccharide‐based biomaterials in a journey from3Dto4Dprinting	13
Silk fibroin and ceramic scaffolds: Comparative in vitro studies for bone regeneration	13
Platelet membrane camouflaged AIEgen‐mediated photodynamic therapy improves the effectiveness of anti‐PD‐L1 immunotherapy in large‐burden tumors	12
Modulating neuroinflammation through molecular, cellular and biomaterial‐based approaches to treat spinal cord injury	12
Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis	12
Hyaluronic acid‐g‐lipoic acid granular gel for promoting diabetic wound healing	12
Transplantation of neuron‐inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury	12
Co‐delivery of dendritic cell vaccine and anti‐PD‐1 antibody with cryomicroneedles for combinational immunotherapy	12
An EPO‐loaded multifunctional hydrogel synergizing with adipose‐derived stem cells restores neurogenic erectile function via enhancing nerve regeneration and penile rehabilitation	12
A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery	12
Novel nanofibrous membrane‐supporting stem cell sheets for plasmid delivery and cell activation to accelerate wound healing	12
Microsampling tools for collecting, processing, and storing blood at the point‐of‐care	12
Predicting T‐cell quality during manufacturing through an artificial intelligence‐based integrative multiomics analytical platform	12
Application of nano‐radiosensitizers in combination cancer therapy	12
Customized flexible hollow microneedles for psoriasis treatment with reduced‐dose drug	11
Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration	11
Deep learning‐based multimodal fusion network for segmentation and classification of breast cancers using B‐mode and elastography ultrasound images	11
Peptide‐functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration	11
An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection	11
Engineering placenta‐like organoids containing endogenous vascular cells from human‐induced pluripotent stem cells	11
Targeted brain delivery of RVG29‐modified rifampicin‐loaded nanoparticles for Alzheimer's disease treatment and diagnosis	11
Synergy of antioxidant and M2 polarization in polyphenol‐modified konjac glucomannan dressing for remodeling wound healing microenvironment	11
Wearable biosensors for human fatigue diagnosis: A review	11
Point‐of‐care detection of Japanese encephalitis virus biomarker in clinical samples using a portable smartphone‐enabled electrochemical “Sensit” device	10
Novel piperazine‐based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety	10
The microbiota‐gut‐brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models	10
Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat‐shock protein family	10
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co‐expression network analysis	10
Direct administration of mesenchymal stem cell‐derived mitochondria improves cardiac function after infarction via ameliorating endothelial senescence	10
Therapeutic potential of nanoceria pretreatment in preventing the development of urological chronic pelvic pain syndrome: Immunomodulation via reactive oxygen species scavenging and SerpinB2	10
Non‐invasive in vivo monitoring of transplanted stem cells in 3D‐bioprinted constructs using near‐infrared fluorescent imaging	10
Recent advances in cellular biosensor technology to investigate tau oligomerization	10
Long term therapeutic effects of icariin‐loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP‐β/G‐CSF/noncanonical NF‐	10
Tripartite collaboration of blood‐derived endothelial cells, next generation RNA sequencing and bioengineered vessel‐chip may distinguish vasculopathy and thrombosis among sickle cell disea	10
Tracking metabolic responses based on macronutrient consumption: A comprehensive study to continuously monitor and quantify dual markers (cortisol and glucose) in human sweat using WATCH se	10
Evaluation of native and non‐native biomaterials for engineering human skin tissue	10
A novel soft cardiac assist device based on a dielectric elastomer augmented aorta: An in vivo study	9
Assessment of human adipose‐derived stem cell on surface‐modified silicone implant to reduce capsular contracture formation	9
Atomic force spectroscopy‐based essay to evaluate oocyte postovulatory aging	9
Enhancing adoptive T‐cell therapy with fucoidan‐based IL‐2 delivery microcapsules	9
Pin1/YAP pathway mediates matrix stiffness‐induced epithelial–mesenchymal transition driving cervical cancer metastasis via a non‐Hippo mechanism	9
Fe‐containing metal–organic framework with D‐penicillamine for cancer‐specific hydrogen peroxide generation and enhanced chemodynamic therapy	9
Genetically engineered nano‐melittin vesicles for multimodal synergetic cancer therapy	9
Adjustable extracellular matrix rigidity tumor model for studying stiffness dependent pancreatic ductal adenocarcinomas progression and tumor immunosuppression	9
Engineering elastic sealants based on gelatin and elastin‐like polypeptides for endovascular anastomosis	9
Stable nebulization and muco‐trapping properties of regdanvimab/IN‐006 support its development as a potent, dose‐saving inhaled therapy for COVID‐19	9
pH‐sustaining nanostructured hydroxyapatite/alginate composite hydrogel for gastric protection and intestinal release of Lactobacillus rhamnosusGG	9
SERS spectroscopy with machine learning to analyze human plasma derived sEVs for coronary artery disease diagnosis and prognosis	9
Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing	9
Cell stiffness predicts cancer cell sensitivity to ultrasound as a selective superficial cancer therapy	9
Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis	9
Near‐infrared‐induced drug release from antibody–drug double conjugates exerts a cytotoxic photo‐bystander effect	9