JCI Insight

Article	Citations
An immune-based biomarker signature is associated with mortality in COVID-19 patients	274
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease	186
A simple protein-based surrogate neutralization assay for SARS-CoV-2	184
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade	165
Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin	152
Natural mucosal barriers and COVID-19 in children	127
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis	116
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis	108
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes	104
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID	104
Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury	102
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression	99
Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury	98
Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma	95
High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19	94
Cardiovascular complications of COVID-19	92
SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8	89
Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors	84
Mitophagy protects β cells from inflammatory damage in diabetes	83
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19	81
Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy	79
PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells	78
A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients	78
SARS-CoV-2 vaccines: a triumph of science and collaboration	78
Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90	76

PDX-derived organoids model in vivo drug response and secrete biomarkers	74
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis	72
Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function	70
CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer	70
Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis	70
Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells	66
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease	66
Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection	65
Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination–specific humoral and cellular immunity in kidney transplant recipients	64
Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine	64
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus	63
Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence	63
Canagliflozin extends life span in genetically heterogeneous male but not female mice	63
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19	61
Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis	61
Obesity results in adipose tissue T cell exhaustion	61
Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity	60
LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling	59
Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension	59
Particulate matter causes skin barrier dysfunction	59
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non–small cell lung cancer	58
Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS	58
Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans	57
Gut-derived acetate promotes B10 cells with antiinflammatory effects	57
Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function	57
Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques	57
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency	56
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response	55
ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies	55
Mechanosensitive Piezo1 channels mediate renal fibrosis	55
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade	54
IL-13 is a driver of COVID-19 severity	54
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction	54
Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC	54
Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics	53
Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation	53
Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population	52
Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis	51
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML	50
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD	50
Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy	50
Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension	49
Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception	49
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity	48
p38 MAPKs — roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets	48
Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial	48
Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury	47
Long-term follow-up of dynamic brain changes in patients recovered from COVID-19 without neurological manifestations	47
Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration	47
A potential pathogenic association between periodontal disease and Crohn’s disease	47

Deficiency of Notch signaling in pericytes results in arteriovenous malformations	46
Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease	46
The negative feedback loop of NF-κB/miR-376b/NFKBIZ in septic acute kidney injury	46
Blood donor exposome and impact of common drugs on red blood cell metabolism	45
In utero human intestine harbors unique metabolome, including bacterial metabolites	45
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation	45
Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension	45
Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint	45
TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response	45
Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking	45
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection	44
Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata	44
Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions	44
Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model	44
CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity	44
CD8+ T cell–derived IL-13 increases macrophage IL-10 to resolve neuropathic pain	44
HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy	44
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents	43
PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer	43
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes	43
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis	43
A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren’s syndrome	43
Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans	43
The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission	42
A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2	42
SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes	42
Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects	42
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza	41
High FODMAP diet causes barrier loss via lipopolysaccharide-mediated mast cell activation	41
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2	41
Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition	41
Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease	41
Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation	40
MyD88/CD40 signaling retains CAR T cells in a less differentiated state	40
Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment	40
Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 delta variant infections	40
Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa	40
Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation	40
Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator	39
Obesity-induced inflammation: The impact of the hematopoietic stem cell niche	39
A single-cell atlas of the myometrium in human parturition	39
Direct imaging of glymphatic transport using H217O MRI	39
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma	39
Cervicovaginal microbiota and metabolome predict preterm birth risk in an ethnically diverse cohort	38
Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis	38
Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases	38
Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses	38
Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis	38
SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer	38
A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients	38
Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells	38
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer	37
UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner	37
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa	37
TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis	37
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis	37
Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness	37
Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions	37
Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing	37
Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis	37
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris	37
Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing	37
Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin	36
RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease	36
High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity	35
NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE	35
Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes	35
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors	35
Liquid biopsy reveals collateral tissue damage in cancer	35
Epithelial miR-141 regulates IL-13–induced airway mucus production	35
Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19	35
Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor	35
Autoantibodies stabilize neutrophil extracellular traps in COVID-19	35
Persistence of an intact HIV reservoir in phenotypically naive T cells	35
Exercise intolerance and rapid skeletal muscle energetic decline in human age-associated frailty	34
Contemporary perspectives on heterotopic ossification	34
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern	34
Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide	34
Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection	34
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema	34

Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice	34
The dynamics of human bone marrow adipose tissue in response to feeding and fasting	34
L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus	34
Matrin 3 in neuromuscular disease: physiology and pathophysiology	34
Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood	33
Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS	33
Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis	33
Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia	33
Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models	33
IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms	33
Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore–Washington metropolitan area	33
Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease	33
Leukocytes mediate disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome	33
Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome	32
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022	32
MMP2 and TLRs modulate immune responses in the tumor microenvironment	32
Targeting IL-1β as an immunopreventive and therapeutic modality for K-ras–mutant lung cancer	32
GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells	32
microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production	32
Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia	32
Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva	32
Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells	32
Deep learning–based molecular morphometrics for kidney biopsies	32
Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay	31
SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements	31
Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection	31
Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy	31
IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function	31
Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma	31
Type 2 dendritic cells mediate control of cytotoxic T cell resistant tumors	30
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation	30
Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity	30
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways	30
Plasma metabolomics reveals disrupted response and recovery following maximal exercise in myalgic encephalomyelitis/chronic fatigue syndrome	30
Targeting the undruggable oncogenic KRAS: the dawn of hope	30
Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2	30
Role of endothelial cells in pulmonary fibrosis via SREBP2 activation	30
Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice	30
In vivo grafting of large engineered heart tissue patches for cardiac repair	30
A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing	30
Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis	30
Intravenous allogeneic umbilical cord blood–derived mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa patients	30
JAK inhibitor blocks COVID-19 cytokine–induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids	30
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic–induced necroptosis	30
Human CD4+CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation	30
Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding	30
ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors	29
Reduced replication fork speed promotes pancreatic endocrine differentiation and controls graft size	29
Constitutive bone marrow adipocytes suppress local bone formation	29
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	29
Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations	29
Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program	29
Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer	29
IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes	29
Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy	29
A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies	29
Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination	29
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling	29
Cell stress response impairs de novo NAD+ biosynthesis in the kidney	29
Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis	29
C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness	29
IL-13–programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function	29
Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling	28
Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington’s disease	28
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity	28
A road map from single-cell transcriptome to patient classification for the immune response to trauma	28
Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk	28
Activation of skeletal muscle–resident glial cells upon nerve injury	28
Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation	28
Immune determinants of Barrett’s progression to esophageal adenocarcinoma	28
Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model	28
Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial	28
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis	28
Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post–COVID-19 syndrome	27
Determinants of brain swelling in pediatric and adult cerebral malaria	27
Distinct antibody repertoires against endemic human coronaviruses in children and adults	27
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota	27
Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection	27
Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration	27
Magnetic resonance imaging of cerebrospinal fluid outflow after low-rate lateral ventricle infusion in mice	27
Seizures elevate gliovascular unit Ca2+ and cause sustained vasoconstriction	27
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3	27
IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis	27
NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns	27
PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization	27
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity	27
Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis	27
Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes	27
Chromosome 8 gain is associated with high-grade transformation in MPNST	27
Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain	27
Resident macrophage subpopulations occupy distinct microenvironments in the kidney	26
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation	26
Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10	26
Inhibition of astrocyte hemichannel improves recovery from spinal cord injury	26
Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans	26