JCI Insight

Papers
(The TQCC of JCI Insight is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)
ArticleCitations
The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling127
Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis123
CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking118
N-glycosylation in the SERPIN domain of C1-Esterase Inhibitor in hereditary angioedema110
Obesity modulates NK cell activity via LDL and DUSP1 signaling for populations with adverse social determinants109
The impact of remdesivir on SARS-CoV-2 evolution in vivo106
Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation102
Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells93
Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease92
Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation driven colorectal cancers84
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses81
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma78
Hematopoietic stem cell–derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide76
Transcriptome and DNA methylome analyses reveal underlying mechanisms for the racial disparity in uterine fibroids75
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity72
T follicular regulatory cells in food allergy promote IgE via IL-471
High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones70
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer70
Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function68
Circadian transcriptome of pancreatic adenocarcinoma unravels chronotherapeutic targets66
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas65
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate64
Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy64
Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract64
ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission64
Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates through cleaving TFIIA63
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression62
Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells61
MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability61
Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy61
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice60
Myosin folding boosts solubility in cardiac muscle sarcomeres59
Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson’s disease58
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir57
Distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy-sensitive than papillary thyroid cancer57
CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon57
Abortion rights are health care rights56
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate56
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling55
Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice55
Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA154
Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice54
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism53
FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain53
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes53
Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer52
Natural antibodies drive type 2 immunity in response to damage associated molecular patterns52
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort51
Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis51
ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure50
Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE50
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice50
Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G50
The determinants of complication trajectories in American Indians with type 2 diabetes49
A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma49
Serial intravital imaging captures dynamic and functional endothelial remodeling with single-cell resolution49
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia48
CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling47
SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis47
Inhibition of bromodomain extraterminal histone readers alleviates skin fibrosis in experimental models of scleroderma47
Establishment of a reproducible and minimally invasive ischemic stroke model in swine46
Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis45
Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP29045
IgV somatic mutation of human anti–SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity44
A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection44
Longitudinal analysis of memory Tfh cells and antibody response following CoronaVac vaccination44
Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice44
Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells44
Flow pattern–dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cells43
Gaps between college and starting an MD-PhD program are adding years to physician-scientist training time43
Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis43
Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis43
Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease43
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes43
Cytomegalovirus immunity in high-risk liver transplant recipients following preemptive antiviral therapy versus prophylaxis42
Natural history of retinitis pigmentosa based on genotype, vitamin A/E supplementation, and an electroretinogram biomarker42
Endothelial cell–specific LAT1 ablation normalizes tumor vasculature42
Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis42
Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus42
Dysregulated immunologic landscape of the early host response in melioidosis41
A surgical method for continuous intraportal infusion of gut microbial metabolites in mice41
T cell responses and clinical symptoms among infants with congenital cytomegalovirus infection41
Sociodemographic factors and research experience impact MD-PhD program acceptance41
Molecular profiling identifies distinct subtypes across TP53 mutant tumors41
An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases40
Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice40
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models39
IFN-signaling gene expression as a diagnostic biomarker for monogenic interferonopathies39
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma39
Activation of autoreactive lymphocytes in the lung by STING gain-of-function mutation expressing radioresistant cells39
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease38
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma38
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival38
Transient inhibition of sodium-glucose cotransporter 2 after ischemia/reperfusion injury ameliorates chronic kidney disease38
Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency38
Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide38
Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension38
Development of a humanized mouse model with functional human materno-fetal interface immunity37
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors37
MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors37
Diurnal rhythms in varicella vaccine effectiveness37
Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype37
Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection37
A pathogenic in-frame deletion-insertion variant in BEST1 phenocopies Stargardt disease37
Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis37
Single-cell RNA-seq analysis reveals cell subsets and gene signatures associated with Rheumatoid Arthritis Disease Activity37
Antibody-mediated depletion of CCR10+ EphA3+ cells ameliorates fibrosis in IPF36
VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system35
The m6A methyltransferase METTL16 negatively regulates MCP1 expression in mesenchymal stem cells during monocyte recruitment35
Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance35
TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy35
RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer35
Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair35
Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts35
Evolutionary mode and timing of dissemination of high-grade serous carcinomas34
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion34
SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside34
Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency34
Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection34
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.134
The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age34
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells34
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice33
YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis33
A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis33
Immune landscape of a genetically engineered murine model of glioma compared with human glioma33
CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis33
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV32
(Pro)renin receptor signaling in hypothalamic tyrosine hydroxylase neurons is required for obesity-associated glucose metabolic impairment32
A CD6-targeted antibody-drug conjugate as a potential therapy for T cell–mediated disorders32
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility32
Molecular subtyping improves breast cancer diagnosis in the Copenhagen Breast Cancer Genomics Study32
An ELF4 hypomorphic variant results in NK cell deficiency32
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis32
Interferon-dependent signaling is critical for viral clearance in airway neutrophils32
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish32
Failure to breathe persists without air hunger or alarm following amygdala seizures32
CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice31
SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface31
Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function31
Single-epitope T cell–based vaccine protects against SARS-CoV-2 infection in a preclinical animal model31
miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α31
Anti–NF-κB peptide derived from nuclear acidic protein attenuates ovariectomy-induced osteoporosis in mice31
Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci31
Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation31
An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus30
A brief morning rest period benefits cardiac repair in pressure overload hypertrophy and postmyocardial infarction30
Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission30
Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy30
miR-122 promotes virus-induced lung disease by targeting SOCS130
Short- and long-term T cell and antibody responses following dexamethasone treatment in COVID-1930
Protein synthesis inhibitor omacetaxine is effective against hepatocellular carcinoma30
Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease30
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration30
SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells30
LIN28B induces a differentiation program through CDX2 in colon cancer30
HPV transcript expression affects cervical cancer response to chemoradiation30
Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness30
Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesis30
Heteroplasmic and homoplasmic m.616T>C in mitochondria tRNAPhe promote isolated chronic kidney disease and hyperuricemia29
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-229
Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration29
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus29
CD6 is a target for cancer immunotherapy29
Differential localization and limited cytotoxic potential of duodenal CD8+ T cells29
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis29
Protein biomarker signature in patients with spinal and bulbar muscular atrophy29
Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia29
CD138 expression is a molecular signature but not a developmental requirement for RORγt+ NKT17 cells29
Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells29
The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention29
PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization29
SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer29
Deletion of AMPK minimizes graft-versus-host disease through an early impact on effector donor T cells29
Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection28
SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases28
Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes28
Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation28
Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency28
The financial impact of MD-PhD training compared with MD training for academic physicians28
LMAN1 serves as a cargo receptor for thrombopoietin28
miR–9-5p regulates immunometabolic and epigenetic pathways in β-glucan–trained immunity via IDH3α28
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation28
Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer27
Prevention of guanylyl cyclase–B dephosphorylation rescues achondroplastic dwarfism27
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia27
Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus27
Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals27
The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy27
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation27
PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia27
MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance27
Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice27
Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells27
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice27
Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma27
Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice26
Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome26
Immunogenetics associated with severe coccidioidomycosis26
Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence26
HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones26
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production26
Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration26
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis26
Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions26
Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors26
C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy26
In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells25
CC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice25
Vagal gut-brain signaling mediates amygdaloid plasticity, affect, and pain in a functional dyspepsia model25
Epithelial microRNA-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma25
Species-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease25
Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus25
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy25
The unfolded protein response links ER stress to cancer-associated thrombosis25
MicroRNA-1 protects the endothelium in acute lung injury25
Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma24
Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR224
Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency24
Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis24
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection24
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection24
B cell–intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice24
Role of c-Met/β1 integrin complex in the metastatic cascade in breast cancer24
Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart24
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection24
Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system24
Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair–deficient colorectal cancer tissue24
Lymphotoxin β receptor and tertiary lymphoid organs shape acute and chronic allograft rejection24
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade24
CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy24
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation24
Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma24
Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation24
Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome24
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response24
The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer24
Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging24
Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice24
Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies24
Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy23
T-bet+CD27+CD21– B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants23
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors23
Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats23
Intraepithelial CD15 infiltration identifies high-grade anal dysplasia in people with HIV23
RAG1 splicing mutation causes enhanced B cell differentiation and autoantibody production23
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy23
Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown23
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation23
ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma23
0.080157995223999