JCI Insight

Article	Citations
Neutrophil extracellular traps in COVID-19	559
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status	391
The laboratory tests and host immunity of COVID-19 patients with different severity of illness	365
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity	346
Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease	292
The complement system in COVID-19: friend and foe?	278
An immune-based biomarker signature is associated with mortality in COVID-19 patients	258
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections	232
Clinical and pathological investigation of patients with severe COVID-19	218
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist	183
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis	178
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease	175
A simple protein-based surrogate neutralization assay for SARS-CoV-2	173
The senescence-associated secretome as an indicator of age and medical risk	172
Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination	156
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade	144
Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity	127
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer	127
A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis	122
Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice	120
Natural mucosal barriers and COVID-19 in children	117
Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin	114
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis	104
IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19	102
Commensal bacteria stimulate antitumor responses via T cell cross-reactivity	99

Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development	96
Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis	94
High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19	91
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID	91
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis	85
Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury	84
Cardiovascular complications of COVID-19	84
Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma	82
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes	82
Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme	79
Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury	79
Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors	78
A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients	77
SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8	76
Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer	73
Molecular detection of SARS-CoV-2 in formalin-fixed, paraffin-embedded specimens	73
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19	72
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression	71
In vivo–directed evolution of adeno-associated virus in the primate retina	70
CCL5 mediates CD40-driven CD4+ T cell tumor infiltration and immunity	69
Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors	68
Mitophagy protects β cells from inflammatory damage in diabetes	68
Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy	68
SARS-CoV-2 vaccines: a triumph of science and collaboration	66
PDX-derived organoids model in vivo drug response and secrete biomarkers	66
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation	64
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody	64
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19	63
Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function	61
PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells	61
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis	59
Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes	59
Integrated urine proteomics and renal single-cell genomics identify an IFN-γ response gradient in lupus nephritis	57
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease	57
Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis	57
Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination–specific humoral and cellular immunity in kidney transplant recipients	56
Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine	56
Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection	56
Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells	55
Obesity results in adipose tissue T cell exhaustion	55
A rational mouse model to detect on-target, off-tumor CAR T cell toxicity	54
Canagliflozin extends life span in genetically heterogeneous male but not female mice	54
Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity	54
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD	53
Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis	53
CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation	53
LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling	52
Pancreatic tropism of metastatic renal cell carcinoma	52
Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence	52
Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90	52

Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency	52
Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer	51
Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques	51
Gut microbial metabolites alter IgA immunity in type 1 diabetes	51
Particulate matter causes skin barrier dysfunction	50
Prehospital plasma is associated with distinct biomarker expression following injury	50
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus	50
Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis	50
Regulation of glycolysis and the Warburg effect in wound healing	50
ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies	49
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response	49
IL-13 is a driver of COVID-19 severity	49
Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment	49
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade	48
Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T cell therapy	48
CX3CR1–CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment	48
Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS	48
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction	47
CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer	47
Gut-derived acetate promotes B10 cells with antiinflammatory effects	47
Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans	47
Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics	47
Patient ancestry significantly contributes to molecular heterogeneity of systemic lupus erythematosus	46
Natural killer cell and stroma abundance are independently prognostic and predict gastric cancer chemotherapy benefit	46
Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension	46
A replication-competent late liver stage–attenuated human malaria parasite	46
Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function	46
ANGPTL8 has both endocrine and autocrine effects on substrate utilization	46
Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease	46
Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation	45
Tryptophan catabolism reflects disease activity in human tuberculosis	45
T cell exosome–derived miR-142-3p impairs glandular cell function in Sjögren’s syndrome	45
COVID-19 in older adults: clinical, psychosocial, and public health considerations	44
Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration	44
Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension	44
Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis	43
Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint	43
Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection	43
Leptin receptor–expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice	43
S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress–dependent VEGF-C signaling	43
PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma	43
Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population	43
Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC	42
Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells	42
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD	42
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents	42
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity	42
Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions	41
Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease	41
Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice	41
The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD	41
Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation	41
The negative feedback loop of NF-κB/miR-376b/NFKBIZ in septic acute kidney injury	40
Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury	40
Blood donor exposome and impact of common drugs on red blood cell metabolism	40
Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer	40
Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production	40
Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration	39
DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer	39
Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception	39
A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2	39
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza	39
Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 delta variant infections	39
Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing	39
Obesity-induced inflammation: The impact of the hematopoietic stem cell niche	39
HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy	39
Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects	38
Deficiency of Notch signaling in pericytes results in arteriovenous malformations	38
Long-term follow-up of dynamic brain changes in patients recovered from COVID-19 without neurological manifestations	38
Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1	38
Mechanosensitive Piezo1 channels mediate renal fibrosis	38
Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2	38
Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage–related diseases	38
Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression	38
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation	38
Single-cell repertoire tracing identifies rituximab-resistant B cells during myasthenia gravis relapses	37
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML	37
Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy	37
PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer	37
Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension	37

RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism	37
Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome	37
TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women	36
A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients	36
Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata	36
Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease	36
A potential pathogenic association between periodontal disease and Crohn’s disease	36
A single-cell atlas of the myometrium in human parturition	36
Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking	36
Direct imaging of glymphatic transport using H217O MRI	36
Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition	36
Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator	36
Autoantibodies stabilize neutrophil extracellular traps in COVID-19	36
TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response	36
Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model	36
Scleraxis is required for the growth of adult tendons in response to mechanical loading	36
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non–small cell lung cancer	36
p38 MAPKs — roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets	36
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes	36
Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans	36
Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy	35
Kynurenines link chronic inflammation to functional decline and physical frailty	35
SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes	35
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris	35
Leptin decreases de novo lipogenesis in patients with lipodystrophy	34
MUC1-C drives stemness in progression of colitis to colorectal cancer	34
Persistence of an intact HIV reservoir in phenotypically naive T cells	34
Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets	34
Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment	34
Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells	34
New (re)purpose for an old drug: purinergic modulation may extinguish the COVID-19 thromboinflammatory firestorm	34
Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis	34
Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis	34
MyD88/CD40 signaling retains CAR T cells in a less differentiated state	33
Cervicovaginal microbiota and metabolome predict preterm birth risk in an ethnically diverse cohort	33
Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease	33
High FODMAP diet causes barrier loss via lipopolysaccharide-mediated mast cell activation	33
Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin	33
Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease	33
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells	33
Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis	33
Liquid biopsy reveals collateral tissue damage in cancer	32
Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period	32
Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells	32
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern	32
TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy	32
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022	32
Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor	32
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma	32
Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models	32
RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease	32
CD8+ T cell–derived IL-13 increases macrophage IL-10 to resolve neuropathic pain	32
In utero human intestine harbors unique metabolome, including bacterial metabolites	32
TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis	31
Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis	31
Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis	31
Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa	31
Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases	31
Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair	31
L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus	31
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3–CD8+ T cells	31
Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms	30
Matrin 3 in neuromuscular disease: physiology and pathophysiology	30
Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among women in Rakai, Uganda	30
Deep learning–based molecular morphometrics for kidney biopsies	30
Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19	30
Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis	30
microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production	30
Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy	30
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema	30
Epithelial miR-141 regulates IL-13–induced airway mucus production	30
Cardiovascular response to small-molecule APJ activation	29
Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS	29
The dynamics of human bone marrow adipose tissue in response to feeding and fasting	29
Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore–Washington metropolitan area	29
Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood	29
SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer	29
Exercise intolerance and rapid skeletal muscle energetic decline in human age-associated frailty	29
IL-12 from endogenous cDC1, and not vaccine DC, is required for Th1 induction	29
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa	29
Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes	29
Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection	29
Intercalated cell BKα subunit is required for flow-induced K+ secretion	29
Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice	29
CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity	29
Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness	29
Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions	29
NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE	29
Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay	29
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors	29
Age-dependent regulation of cell-mediated collagen turnover	28
Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection	28
A porcine model of phenylketonuria generated by CRISPR/Cas9 genome editing	28
Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis	28
Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts	28