JCI Insight

Papers
(The H4-Index of JCI Insight is 57. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
Neutrophil extracellular traps in COVID-19559
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status391
The laboratory tests and host immunity of COVID-19 patients with different severity of illness365
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity346
Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease292
The complement system in COVID-19: friend and foe?278
An immune-based biomarker signature is associated with mortality in COVID-19 patients258
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections232
Clinical and pathological investigation of patients with severe COVID-19218
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist183
Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis178
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease175
A simple protein-based surrogate neutralization assay for SARS-CoV-2173
The senescence-associated secretome as an indicator of age and medical risk172
Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination156
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade144
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer127
Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity127
A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis122
Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice120
Natural mucosal barriers and COVID-19 in children117
Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin114
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis104
IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19102
Commensal bacteria stimulate antitumor responses via T cell cross-reactivity99
Angiogenesis stimulated by elevated PDGF-BB in subchondral bone contributes to osteoarthritis development96
Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis94
High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-1991
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID91
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis85
Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury84
Cardiovascular complications of COVID-1984
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes82
Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma82
Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury79
Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme79
Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors78
A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients77
SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/876
Molecular detection of SARS-CoV-2 in formalin-fixed, paraffin-embedded specimens73
Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer73
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-1972
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression71
In vivo–directed evolution of adeno-associated virus in the primate retina70
CCL5 mediates CD40-driven CD4+ T cell tumor infiltration and immunity69
Mitophagy protects β cells from inflammatory damage in diabetes68
Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy68
Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors68
PDX-derived organoids model in vivo drug response and secrete biomarkers66
SARS-CoV-2 vaccines: a triumph of science and collaboration66
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation64
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody64
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-1963
Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function61
PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells61
Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes59
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis59
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease57
Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis57
Integrated urine proteomics and renal single-cell genomics identify an IFN-γ response gradient in lupus nephritis57
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