OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling	127
Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis	123
CD40L modulates transcriptional signatures of neutrophils in the bone marrow associated with development and trafficking	118
N-glycosylation in the SERPIN domain of C1-Esterase Inhibitor in hereditary angioedema	110
Obesity modulates NK cell activity via LDL and DUSP1 signaling for populations with adverse social determinants	109
The impact of remdesivir on SARS-CoV-2 evolution in vivo	106
Multiomics of Bohring-Opitz syndrome truncating ASXL1 mutations identify canonical and noncanonical Wnt signaling dysregulation	102
Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells	93
Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease	92
Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation driven colorectal cancers	84
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	81
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma	78
Hematopoietic stem cell–derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide	76
Transcriptome and DNA methylome analyses reveal underlying mechanisms for the racial disparity in uterine fibroids	75
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	72
T follicular regulatory cells in food allergy promote IgE via IL-4	71
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer	70
High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones	70
Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function	68
Circadian transcriptome of pancreatic adenocarcinoma unravels chronotherapeutic targets	66
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas	65
Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy	64
Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract	64
ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission	64
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate	64

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates through cleaving TFIIA	63
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression	62
Coreceptor therapy has distinct short- and long-term tolerogenic effects intrinsic to autoreactive effector T cells	61
MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability	61
Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy	61
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	60
Myosin folding boosts solubility in cardiac muscle sarcomeres	59
Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson’s disease	58
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir	57
Distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy-sensitive than papillary thyroid cancer	57
CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon	57
Abortion rights are health care rights	56
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	56
Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice	55
Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling	55
Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1	54
Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice	54
FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain	53
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes	53
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism	53
Natural antibodies drive type 2 immunity in response to damage associated molecular patterns	52
Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer	52
Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis	51
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort	51
Selective CAR T cell–mediated B cell depletion suppresses IFN signature in SLE	50
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice	50
Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G	50
ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure	50