OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 53. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Dysregulated immunologic landscape of the early host response in melioidosis	160
Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration	138
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	137
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	129
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	126
Antibody-mediated depletion of CCR10+ EphA3+ cells ameliorates fibrosis in IPF	117
LMAN1 serves as a cargo receptor for thrombopoietin	108
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	106
Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair–deficient colorectal cancer tissue	103
Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission	95
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	94
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	91
Prevention of guanylyl cyclase–B dephosphorylation rescues achondroplastic dwarfism	88
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity	85
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	85
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	84
Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation	81
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure	77
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	77
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility	75
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	75
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis	74
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	73
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	70
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	69

Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	69
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	68
Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer	68
Development of a humanized mouse model with functional human materno-fetal interface immunity	67
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	66
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes	66
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	64
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	63
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection	63
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	62
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	62
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans	61
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	61
Recurrent moderate hypoglycemia accelerates the progression of Alzheimer’s disease through impairment of the TRPC6/GLUT3 pathway	59
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	59
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	59
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV	59
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells	59
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion	59
Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice	59
Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis	58
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	57
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	56
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	53
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	53
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	53
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition	53
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	53