OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 53. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	194
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion	174
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk	172
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	133
From Improvised to Intentional: Re-Imagining the Physician-Scientist Career Path	123
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	117
Intranodal expansion of follicular T helper cells in patients with multiple sclerosis	115
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses	97
Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome	94
Chemotherapy-induced reactive myelopoiesis promotes expansion of immunosuppressive neutrophil-like monocytes in mice and humans	93
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	91
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	87
Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice	87
Characterization of anticancer therapy–induced microvascular dysfunction in patients with breast cancer supports targeted intervention	81
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	79
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	79
De novo variant in RING finger protein 213 causes systemic vasculopathy	78
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	77
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	76
Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication	76
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	76
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV	70
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health	68
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	67
Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue	67

Development of a humanized mouse model with functional human materno-fetal interface immunity	65
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	64
Urine proteomic signatures of kidney function decline after hospitalization	64
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	62
Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	62
Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production	61
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	61
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	61
Th2 skewing in patients with disseminated coccidioidomycosis	60
Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity	60
Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis	60
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	58
Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection	57
Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury	57
LMAN1 serves as a cargo receptor for thrombopoietin	56
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	56
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	55
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	55
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid–dendritic cell leukemia	55
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs	55
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models	55
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	55
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	55
Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury	54
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	54
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition	54
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy	54
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	53
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	53
Regulation of selective class switching provides long-term therapeutic benefits for hay fever	53
Health outcomes after national acute sleep deprivation events among the American public	53