OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 54. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Slick K+ channels contribute to cardiac remodeling, fibrosis and dysfunction in post-infarction hearts	203
From Improvised to Intentional: Re-Imagining the Physician-Scientist Career Path	184
Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome	179
A double-edged sword: iron regulation in alveolar lung epithelial repair	125
Endothelial Cell Glycogen Synthase Kinase 3β Promotes Lipotoxic Endotheliopathy and Liver Inflammation in MASH	122
A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency	121
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish	100
AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival	98
Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration	98
Characterization of anticancer therapy–induced microvascular dysfunction in patients with breast cancer supports targeted intervention	94
Regulation of selective class switching provides long-term therapeutic benefits for hay fever	90
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health	87
Intranodal expansion of follicular T helper cells in patients with multiple sclerosis	85
CD4+ and CD8+ T cells are not the main driver of Lassa fever pathogenesis in macaques	82
Macrophage ferritin heavy chain/α-synuclein regulatory axis modulates ferroptosis during kidney injury	79
Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue	78
Health outcomes after national acute sleep deprivation events among the American public	78
Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis	78
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease	78
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy	72
EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice	71
Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity	70
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis	68
Myocardial ATP depletion detected noninvasively predicts sudden cardiac death risk in patients with heart failure	68
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition	66

Mineralocorticoid receptor antagonists and glucocorticoids differentially affect skeletal muscle inflammation and pathology in muscular dystrophy	66
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation	63
Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter	63
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate	62
CNS-dominant human FMRP isoform rescues seizures, fear, and sleep abnormalities in Fmr1-KO mice	62
T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade	62
Interferon-dependent signaling is critical for viral clearance in airway neutrophils	60
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion	60
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation	59
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice	59
Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia	59
A dominant pathogenic MEFV mutation causes atypical pyrin-associated periodic syndromes	59
Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction	58
Dynamic remodeling of portal vessels by Clec4g+ endothelial cells in liver growth and homeostasis	57
LMAN1 serves as a cargo receptor for thrombopoietin	57
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma	57
Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis	57
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk	57
Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians	57
Urine proteomic signatures of kidney function decline after hospitalization	56
De novo variant in RING finger protein 213 causes systemic vasculopathy	56
Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis	56
Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer	56
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG	55
Dysregulated immunologic landscape of the early host response in melioidosis	55
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells	54
The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury	54
Pharmacological induction of MHC-I expression in tumor cells revitalizes T cell antitumor immunity	54
Development of a humanized mouse model with functional human materno-fetal interface immunity	54