OOIR: Observatory of International Research

Papers

(The H4-Index of JCI Insight is 53. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
An immune-based biomarker signature is associated with mortality in COVID-19 patients	274
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade	165
Natural mucosal barriers and COVID-19 in children	127
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis	108
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes	104
Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID	104
Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury	102
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression	99
Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury	98
Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma	95
Cardiovascular complications of COVID-19	92
SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8	89
Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors	84
Mitophagy protects β cells from inflammatory damage in diabetes	83
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19	81
PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells	79
SARS-CoV-2 vaccines: a triumph of science and collaboration	78
A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients	78
Echinatin effectively protects against NLRP3 inflammasome–driven diseases by targeting HSP90	77
PDX-derived organoids model in vivo drug response and secrete biomarkers	74
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis	72
CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer	70
Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis	70
Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function	70
Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells	66

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease	66
Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection	65
Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination–specific humoral and cellular immunity in kidney transplant recipients	64
Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine	64
Canagliflozin extends life span in genetically heterogeneous male but not female mice	63
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus	63
Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis	61
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19	61
Particulate matter causes skin barrier dysfunction	61
Obesity results in adipose tissue T cell exhaustion	61
Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity	60
LncRNA VINAS regulates atherosclerosis by modulating NF-κB and MAPK signaling	59
Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension	59
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non–small cell lung cancer	58
Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS	58
Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques	57
Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans	57
Gut-derived acetate promotes B10 cells with antiinflammatory effects	57
Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function	57
Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency	56
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune response	55
Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC	55
Mechanosensitive Piezo1 channels mediate renal fibrosis	55
IL-13 is a driver of COVID-19 severity	54
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade	54
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction	54
Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation	53
Circulating nuclear DNA structural features, origins, and complete size profile revealed by fragmentomics	53