OOIR: Observatory of International Research

Papers

(The TQCC of Cannabis and Cannabinoid Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Case in Context: Acne Inversa (Hidradenitis Suppurativa)	88
Pharmacokinetics of Oral Minor Cannabinoids in Blood and Brain	51
Cannabidiol Marketing Strategies in the United States: An Analysis of Three Prominent Companies	48
Prosocial Effects of Nonpsychotropic Cannabis sativa in Mice	48
The Utility of THC Cutoff Levels in Blood and Saliva for Detection of Impaired Driving	48
A Double-Blind, Randomized, Placebo-Controlled Test of the Effects of Cannabidiol on Experiences of Test Anxiety Among College Students	47
Intra-Accumbal D1- But not D2-Like Dopamine Receptor Antagonism Reverses the Inhibitory Effects of Cannabidiol on Extinction and Reinstatement of Methamphetamine Seeking Behavior in Rats	46
Stakeholders' Decisions and Preferences for the Provision and Use of Medicinal Cannabis: A Scoping Review	41
Comparative Pharmacokinetic Assessment of Innovative Sublingual, Rectal and Vaporizer Cannabis Products Versus Approved Cannabis Products in Healthy Volunteers	40
Legalization of Smokable Medical Cannabis and Changes in the Dispensed Amount of Δ-9 Tetrahydrocannabinol Per Patient	37
Increased White Matter Coherence Following Three and Six Months of Medical Cannabis Treatment	32
The Endocannabinoid System as a Potential Therapeutic Target for HIV-1-Associated Neurocognitive Disorder	31
Endocannabinoid System Biomarkers in Alzheimer's Disease	31
Cannabis Use and Biomarkers of Inflammation, Immune Activation, and Microbial Translocation in Persons with HIV	30
Understanding and Rebalancing: A Rapid Scoping Review of Cannabis Research Among Indigenous People	30
Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression	29
Kinetics of CBD, Δ⁹-THC Degradation and Cannabinol Formation in Cannabis Resin at Various Temperature and pH Conditions	29
Typical Hits, Grams, or Joints: Evaluating Cannabis Survey Measurement Strategies for Quantifying Consumption	29
A Preliminary Pharmacokinetic Comparison of Δ-9 Tetrahydrocannabinol and Cannabidiol Extract Versus Oromucosal Spray in Healthy Men and Women	29
Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis	28
Letter to the Editor: Response to Dr. Mousavi’s Comments on Ogunsola et al	28
Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective	27
Genome-Wide Identification and Expression Profiles of bZIP Genes in Cannabis sativa L.	27
Shifting the Paradigm on Cannabis Safety	27
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner	27

An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry	25
Impact of Oral Cannabinoids on the Endocannabinoidome and Gut Microbiome in People with HIV on Antiretroviral Therapy (CTN PT028 Pilot Clinical Trial)	25
A Scoping Review on the Medical and Recreational Use of Cannabis During the COVID-19 Pandemic	25
Extending Gender- and Sex-Based Analyses in Cannabis Research: Findings from an Online Sample of Gender Diverse Young Adult Consumers	25
The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Post Hoc Exploratory Analysis of Phase 2/3 Clinical	25
A Thematic Text Analysis of Cannabis Edibles Brand Names	25
Multi-Omics Reveals the Effects of Cannabidiol on Gut Microbiota and Metabolic Phenotypes	24
Sexually Dimorphic Effects of a Single Neonatal Δ9-tetrahydrocannabinol Exposure on Neuronal Dendritic Morphology and Cognitive Functions in Rats	24
Requirements for Cannabis Product Labeling by U.S. State	23
Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation	22
Letter to the Editor: Snoop Dogg's Announcement to “Give Up Smoke” Has Fans Reevaluating Their Own Patterns of Cannabis Use	22
Cannabis Use in Pregnancy and Neonatal Outcomes: A Systematic Review and Meta-Analysis	22
Letter to the Editor: Would Cannabidiol Be a Therapeutic Alternative to Treat Monkeypox Symptoms?	22
Cannabis and Its Permissibility Status	21
In Silico Genome-Wide Analysis of B3 Transcription Factors in Cannabis sativa L.	21
Cannabidiol Pretreatment Reduces Status Epilepticus and Glutamate Uptake Induced by Kainic Acid in Adult Zebrafish	21
Origins ofCannabis sativain Ireland and the Concept of Celtic Hemp: An Interdisciplinary Review	20
Solid-State Microwave Drying for Medical Cannabis Inflorescences: A Rapid and Controlled Alternative to Traditional Drying	20
Changes in Medical Cannabis Use After Recreational Cannabis Legalization in Canada	19
Temporal Trends in Semen Quality, Hormone Levels, and Substance Use Among Infertile Men in Pre- and Post-Cannabis Legalization Eras in Canada	19
Relationship Between Recreational Cannabis Use and Helicobacter pylori Infection	19
Cerebrovascular Effects of Alcohol Combined with Tetrahydrocannabinol	18
Effects of Tetrahydrocannabinol and Cannabidiol on Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Expression in the Adolescent Hippocampus	17
Endocannabinoids and Stress-Related Neurospsychiatric Disorders: A Systematic Review and Meta-Analysis of Basal Concentrations and Response to Acute Psychosocial Stress	17
Cannabinoids for Substance Use Disorder Treatment: What Does the Current Evidence Say?	17
Acknowledgment of Reviewers 2023	17
Cannabis Provenance by Isotope Ratio Analysis	17
The Use of Cannabis sativa L. for Pest Control: From the Ethnobotanical Knowledge to a Systematic Review of Experimental Studies	17
Complex Regional Pain Syndrome Type I: Evidence for the CB1 and CB2 Receptors Immunocontent and Beneficial Effect of Local Administration of Cannabidiol in Mice	16
Call for Special Issue Papers: Sex and Gender Differences: Focus on Cannabis and Cannabinoids	16
Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis	16
Cannabis Roots: Therapeutic, Biotechnological and Environmental Aspects	16
Chemistry and Biological Activities of Cannflavins of the Cannabis Plant	16
Correction to: Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J Mice, by Bouter, et al. Cannabis and Cannabinoid Res	16
A National Survey of Marijuana Use Among U.S. Adults According to Obesity Status, 2016–2022	15
The Effect of Nabiximols on Driving Ability in Adults with Chronic Tic Disorders: Results of a Substudy Analysis of the Double-Blind, Randomized, Placebo-Controlled CANNA-TICS Trial	15
Understanding Cannabis-Related Information Needs: An Analysis of Inquiries to the National Cancer Institute's Cancer Information Service	15
Cannabis Use Does Not Increase Risk of Perioperative Complications Following Primary Total Hip Arthroplasty: A Cohort-Matched Comparison	15
Challenges of Extracting and Determining Cannabinoids in Different Matrices	15
Use of Medical Cannabis in Patients with Gilles de la Tourette's Syndrome in a Real-World Setting	15
Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial	14
An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses	14
Cannabidiol Interferes with Establishment of Δ⁹-Tetrahydrocannabinol-Induced Nausea Through a 5-HT_1A Mechanism	14
Absorbance-Transmittance Excitation Emission Matrix Method for Quantification of Major Cannabinoids and Corresponding Acids: A Rapid Alternative to Chromatography for Rapid Chemotype Discrimination of	14
Baseline Cannabinoid Use Is Associated with Increased Sedation Requirements for Outpatient Endoscopy	14
The Potential Paradoxical Neurocognitive Effects of Cannabis Use in Patients with Psychotic Disorders: A Critical Meta-Review of Meta-Analytical Evidence	14
Assessing Health Care Providers' Knowledge of Medical Cannabis	13
Effects of the Acute and Chronic Administration of Cannabidiol on Cognition in Humans and Animals: A Systematic Review	13
Cannabis Use During Pregnancy Is Associated with the Suppression of Circulating Maternal Cytokines	13
Perinatal CBD or THC Exposure Results in Lasting Resistance to Fluoxetine in the Forced Swim Test: Reversal by Fatty Acid Amide Hydrolase Inhibition	13

Re: “Regular Use of Cannabis in Female Athletes Is Associated with a Reduction in Early Anaerobic Power Production” by Lisano et al.	13
Cannabinoid Photochemistry: An Underexplored Opportunity	13
Systematic Review on Transdermal/Topical Cannabidiol Trials: A Reconsidered Way Forward	13
Oral Cannabidiol Treatment Is Associated with an Anti-Inflammatory Gene Expression Signature in Myeloid Cells of People Living with HIV	13
Investigating the Relationship Between Cannabis Expectancies and Anxiety, Depression, and Pain Responses After Acute Flower and Edible Cannabis Use	13
Associations of Cannabis Use, Metabolic Dysfunction-Associated Steatotic Liver Disease, and Liver Fibrosis in U.S. Adults	13
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses	13
Potential Utility of Cannabidiol in Stress-Related Disorders	13
A Survey Study of Individuals Using Hexahydrocannabinol Cannabis Products: Use Patterns and Perceived Effects	13
Hexahydrocannabinol on the Light Cannabis Market: The Latest “New” Entry	12
Sex Differences in the Association Between Cumulative Use of Cannabis and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults Study	12
Letter to the Editor: The Receptor(s) via Which Cannabidiol Affects Muscle Signaling: In Need for More Insights	12
A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures	12
Types and Brands of Derived Psychoactive Cannabis Products: An Online Retail Assessment, 2023	12
Effect of Cannabidiol on Cyclooxygenase Type 1 and 2 Expression and Function in Human Neutrophils	12
Effects of Medical Cannabis Treatment for Autistic Children on Anxiety and Restricted and Repetitive Behaviors and Interests: An Open-Label Study	12
Δ9-Tetrahydrocannabinol Treatment Modifies Insulin Secretion in Pancreatic Islets from Prediabetic Mice Under Hypercaloric Diet	12
Behavioral Effects of Vaporized Delta-8 Tetrahydrocannabinol, Cannabidiol, and Mixtures in Male Rats	12
Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review	12
Toxicological Evaluation and Pain Assessment of Four Minor Cannabinoids Following 14-Day Oral Administration in Rats	11
Δ⁹-THC and CBD in Plasma, Oral Fluid, Exhaled Breath, and Urine from 23 Patients Administered Sativex	11
Preliminary Eye-Tracking Data as a Nonintrusive Marker for Blood Δ-9-Tetrahydrocannabinol Concentration and Drugged Driving	11
Oral Cannabis for Taxane-Induced Neuropathy: A Pilot Randomized Placebo-Controlled Study	11
Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth	11
The Reversal of Empathy-Induced Hypernociception in Male Mice by Intra-Amygdala Administration of Midazolam and Cannabidiol Depends on 5-HT₃ Receptors	11
The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats	11
In Memoriam of Professor Raphael Mechoulam	11
Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells	11
Risks of Cannabinoid Exposure on Birth Outcomes: A Systematic Review	10
Cannabis Use Is Inversely Associated with Overweight and Obesity in Hepatitis B Virus-Infected Patients (ANRS CO22 Hepather Cohort)	10
Daily Cannabidiol Administration for 10 Weeks Modulates Hippocampal and Amygdalar Resting-State Functional Connectivity in Cannabis Users: A Functional Magnetic Resonance Imaging Open-Label Clinical T	10
The Effects of Endogenous Cannabinoids on the Mammalian Respiratory System: A Scoping Review of Cyclooxygenase-Dependent Pathways	10
Origin, Early History, Cultivation, and Characteristics of the Traditional Varieties of Moroccan Cannabis sativa L.	10
A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Ca	10
Letter to the Editor: Cannabis as a Solution to the Opioid Crisis: Is the Cart Before the Horse Again?	10
Prediction and Discovery of Cannabidiol Crystal Polymorph Form 2	10
The Potential of Salivary Lipid-Based Cannabis-Responsive Biomarkers to Evaluate Medical Cannabis Treatment in Children with Autism Spectrum Disorder	10
Chemistry, Crystal Structure, and In Vitro Receptor Binding of Δ10-THC Isomers	10
Running High: Cannabis Users' Subjective Experience of Exercise During Legal Market Cannabis Use Versus No Use in a Naturalistic Setting	10
Cannabinoids in Treating Parkinson's Disease Symptoms: A Systematic Review of Clinical Studies	9
The Cannabis-Dependent Relationship Between Methadone Treatment Dose and Illicit Opioid Use in a Community-Based Cohort of People Who Use Drugs	9
Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-Analysis	9
Licensed Medical Cannabis Use in Gilles de la Tourette Syndrome: A Retrospective Long-term Follow-Up	9
Evaluating the Role of the Endocannabinoid System in Axon Guidance: A Literature Review	9
Symptoms and Extraintestinal Manifestations in Active Cannabis Users with Inflammatory Bowel Disease	8
The Relationship Between Circulating Endogenous Cannabinoids and the Effects of Smoked Cannabis	8
Comparing Cannabis Use Motivations and Dependence Across Regular Cannabis Users Who Have or Have Not Recently Used Psilocybin	8
Electrocardiographic Markers of Arrhythmogenic Risk in Synthetic Cannabinoids Users	8
Clinician Attitudes, Training, and Beliefs About Cannabis: An Interprofessional Assessment	8
The Impact of JWH-133 on Articular Cartilage Regeneration in Osteoarthritis Via Metalloproteinase 13-Dependent Mechanism	8
Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease	8
Does the Quantification of Δ9-Tetrahydrocannabinolic Acid A in Serum/Plasma Provide Any Additional Information About Consumption Pattern from Drivers Under the Influence of Cannabis?	8
Association Between Medical Marijuana Cardholder Status and Antiemetic Overuse	8
Long-Term Frequent Cannabis Use and Related Serum Cannabinoid Levels Are Not Associated with Kidney Dysfunction	8
Workplace Cannabis Policies: A Moving Target	8
Serum Markers of Bone Turnover Following Controlled Administration of Two Medical Cannabis Products in Healthy Adults	8
Reimagining Research with Pregnant Women and Parents Who Consume Cannabis in the Era of Legalization: The Value of Integrating Intersectional Feminist and Participatory Action Approaches	8
An Ecological Examination of Indica Versus Sativa and Primary Terpenes on the Subjective Effects of Smoked Cannabis: A Preliminary Investigation	8
Effects of High-Potency Cannabis on Psychomotor Performance in Frequent Cannabis Users	8
Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression	8
Cannabis-Responsive Biomarkers: A Pharmacometabolomics-Based Application to Evaluate the Impact of Medical Cannabis Treatment on Children with Autism Spectrum Disorder	8
Cannabinoid Receptor 2 Gene Polymorphism and the Risk of Developing Rheumatoid Arthritis in Lebanese Patients	8
Effect of Cannabistilbene I in Attenuating Angiotensin II-Induced Cardiac Hypertrophy: Insights into Cytochrome P450s and Arachidonic Acid Metabolites Modulation	8
Topical Cannabidiol Application May Not Attenuate Muscle Soreness or Improve Performance: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study	8
In Memoriam of Professor Mary E. Abood	8