Science Advances

Article	Citations
A single–cell type transcriptomics map of human tissues	824
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening	784
Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis	683
More than 1000 rivers account for 80% of global riverine plastic emissions into the ocean	567
Earth beyond six of nine planetary boundaries	497
Agricultural diversification promotes multiple ecosystem services without compromising yield	481
Wireless battery-free wearable sweat sensor powered by human motion	418
Full-color fluorescent carbon quantum dots	398
High-entropy materials for catalysis: A new frontier	395
PM 2.5 polluters disproportionately and systemically affect people of color in the United States	344
Revisiting the PD-1 pathway	324
CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy	307
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM	307
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design	299
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L	298
The United States’ contribution of plastic waste to land and ocean	298
Falling living standards during the COVID-19 crisis: Quantitative evidence from nine developing countries	297
Regulating the absorption spectrum of polydopamine	288
3D printing of highly stretchable hydrogel with diverse UV curable polymers	284
Vaccine optimization for COVID-19: Who to vaccinate first?	274
Plastic waste to fuels by hydrocracking at mild conditions	271
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation	269
23.7% Efficient inverted perovskite solar cells by dual interfacial modification	267
Microenvironment modulation of single-atom catalysts and their roles in electrochemical energy conversion	261
Controlling electrochemical growth of metallic zinc electrodes: Toward affordable rechargeable energy storage systems	250

Low-cost measurement of face mask efficacy for filtering expelled droplets during speech	247
Learning the solution operator of parametric partial differential equations with physics-informed DeepONets	246
A highly stable lithium metal anode enabled by Ag nanoparticle–embedded nitrogen-doped carbon macroporous fibers	243
Reprogrammable shape morphing of magnetic soft machines	240
Abrupt but smaller than expected changes in surface air quality attributable to COVID-19 lockdowns	238
The direct drivers of recent global anthropogenic biodiversity loss	234
Bioinspired mechano-photonic artificial synapse based on graphene/MoS 2 heterostructure	232
Efficient and stable inverted perovskite solar cells with very high fill factors via incorporation of star-shaped polymer	225
A unified vegetation index for quantifying the terrestrial biosphere	223
High-performance wearable thermoelectric generator with self-healing, recycling, and Lego-like reconfiguring capabilities	219
In-sensor reservoir computing for language learning via two-dimensional memristors	214
Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants	213
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease	213
Long-term (1990–2019) monitoring of forest cover changes in the humid tropics	212
Mixed-dimensional MXene-hydrogel heterostructures for electronic skin sensors with ultrabroad working range	211
Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration	210
Recycling of multilayer plastic packaging materials by solvent-targeted recovery and precipitation	209
Ultrasound Doppler-guided real-time navigation of a magnetic microswarm for active endovascular delivery	209
Ultrahigh specific strength in a magnesium alloy strengthened by spinodal decomposition	205
Residential solid fuel emissions contribute significantly to air pollution and associated health impacts in China	203
Exposing unsaturated Cu 1 -O 2 sites in nanoscale Cu-MOF for efficient electrocatalytic hydrogen evolution	203
Direct detection of circular polarized light in helical 1D perovskite-based photodiode	201
Molecularly soldered covalent organic frameworks for ultrafast precision sieving	201
From room temperature to harsh temperature applications: Fundamentals and perspectives on electrolytes in zinc metal batteries	200
Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders	200
The unfolding COVID-19 pandemic: A probability-based, nationally representative study of mental health in the United States	200
Self-standing and flexible covalent organic framework (COF) membranes for molecular separation	200
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm	199
Conductance-stable liquid metal sheath-core microfibers for stretchy smart fabrics and self-powered sensing	198
Environmental exposure enhances the internalization of microplastic particles into cells	196
Slot-die coating large-area formamidinium-cesium perovskite film for efficient and stable parallel solar module	194
Partially exposed RuP 2 surface in hybrid structure endows its bifunctionality for hydrazine oxidation and hydrogen evolution catalysis	191
Iodine reduction for reproducible and high-performance perovskite solar cells and modules	190
Metal-metal interactions in correlated single-atom catalysts	189
Differential effects of intervention timing on COVID-19 spread in the United States	188
Intrapore energy barriers govern ion transport and selectivity of desalination membranes	188
Crystallization in one-step solution deposition of perovskite films: Upward or downward?	187
Model uncertainty, political contestation, and public trust in science: Evidence from the COVID-19 pandemic	186
A smartphone-read ultrasensitive and quantitative saliva test for COVID-19	186
Class I histone deacetylases (HDAC1–3) are histone lysine delactylases	186
Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children	185
Metasurface-based key for computational imaging encryption	185
Stimulus-responsive room temperature phosphorescence materials with full-color tunability from pure organic amorphous polymers	184
Direct probing of atomically dispersed Ru species over multi-edged TiO 2 for highly efficient photocatalytic hydrogen evolution	184
Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces	183
Confining Sn nanoparticles in interconnected N-doped hollow carbon spheres as hierarchical zincophilic fibers for dendrite-free Zn metal anodes	183
Optical secret sharing with cascaded metasurface holography	182
Self-powered electro-tactile system for virtual tactile experiences	181
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer	180
An ultrathin rechargeable solid-state zinc ion fiber battery for electronic textiles	180

Standalone real-time health monitoring patch based on a stretchable organic optoelectronic system	179
Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels	179
A trusted node–free eight-user metropolitan quantum communication network	177
A “Global Safety Net” to reverse biodiversity loss and stabilize Earth’s climate	175
Scalable integrated single-photon source	175
A century of observations reveals increasing likelihood of continental-scale compound dry-hot extremes	175
Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks	174
Meta-optics achieves RGB-achromatic focusing for virtual reality	174
Holographic metasurface gas sensors for instantaneous visual alarms	173
Plant rhizodeposition: A key factor for soil organic matter formation in stable fractions	173
A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics	172
Highly selective and high-performance osmotic power generators in subnanochannel membranes enabled by metal-organic frameworks	172
Soft robotic origami crawler	171
Directional liquid dynamics of interfaces with superwettability	171
A stretchable and strain-unperturbed pressure sensor for motion interference–free tactile monitoring on skins	171
Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity	170
Exponential increase of plastic burial in mangrove sediments as a major plastic sink	170
Restoration of seagrass habitat leads to rapid recovery of coastal ecosystem services	170
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality	168
Artificial tactile perception smart finger for material identification based on triboelectric sensing	165
A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics	165
Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets	164
Changes in global terrestrial live biomass over the 21st century	164
Systemic inequalities for LGBTQ professionals in STEM	164
Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver	163
Deep learning model to predict complex stress and strain fields in hierarchical composites	161
Three-dimensional printing of functionally graded liquid crystal elastomer	160
Engendering persistent organic room temperature phosphorescence by trace ingredient incorporation	160
Highly energy-tunable quantum light from moiré-trapped excitons	159
Indium-antimony-halide single crystals for high-efficiency white-light emission and anti-counterfeiting	158
LRRK2 mediates tubulation and vesicle sorting from lysosomes	158
Amorphization in extreme deformation of the CrMnFeCoNi high-entropy alloy	157
Hydroplastic foaming of graphene aerogels and artificially intelligent tactile sensors	157
Single-site Pt-doped RuO 2 hollow nanospheres with interstitial C for high-performance acidic overall water splitting	156
A clicking confinement strategy to fabricate transition metal single-atom sites for bifunctional oxygen electrocatalysis	156
Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy	156
Nonvolatile programmable silicon photonics using an ultralow-loss Sb 2 Se 3 phase change material	155
Two-qubit silicon quantum processor with operation fidelity exceeding 99%	154
Color-pure red light-emitting diodes based on two-dimensional lead-free perovskites	153
Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids	153
Comprehensive analysis of spatial architecture in primary liver cancer	153
The carrier transition from Li atoms to Li vacancies in solid-state lithium alloy anodes	152
Sequential vacuum-evaporated perovskite solar cells with more than 24% efficiency	152
Spatial heterogeneity and environmental predictors of permafrost region soil organic carbon stocks	151
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression	151
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring	150
The distribution of biodiversity richness in the tropics	150
Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations	150
Satellite-based estimates of decline and rebound in China’s CO 2 emissions during COVID-19 pandemic	149
Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing	147
Partisan pandemic: How partisanship and public health concerns affect individuals’ social mobility during COVID-19	147
Ultrastrong lightweight compositionally complex steels via dual-nanoprecipitation	147
Blackbody-sensitive room-temperature infrared photodetectors based on low-dimensional tellurium grown by chemical vapor deposition	147
On-demand modulating afterglow color of water-soluble polymers through phosphorescence FRET for multicolor security printing	146
Crowdsourced air temperatures contrast satellite measures of the urban heat island and its mechanisms	146
Amorphization mechanism of SrIrO 3 electrocatalyst: How oxygen redox initiates ionic diffusion and structural reorganization	146
Molecular origin of negative component of Helmholtz capacitance at electrified Pt(111)/water interface	145
YAP-mediated mechanotransduction tunes the macrophage inflammatory response	145
Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality	144
Hierarchically porous polyimide/Ti 3 C 2 T x film with stabl	144
Untethered small-scale magnetic soft robot with programmable magnetization and integrated multifunctional modules	143
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome	142
100,000-spin coherent Ising machine	140
A Janus emitter for passive heat release from enclosures	140
Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates	140
ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus –infected chronic skin wound healing	139
Increasing precipitation variability on daily-to-multiyear time scales in a warmer world	139
Global waves synchronize the brain’s functional systems with fluctuating arousal	138
Multilayered electronic transfer tattoo that can enable the crease amplification effect	138
3D bioprinting dual-factor releasing and gradient-structured constructs ready to implant for anisotropic cartilage regeneration	137
Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis	137
GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer	137
Heterogeneous integration of rigid, soft, and liquid materials for self-healable, recyclable, and reconfigurable wearable electronics	136
The SARS-CoV-2 Spike variant D614G favors an open conformational state	135
Autonomous atmospheric water seeping MOF matrix	135
Nonprecious transition metal nitrides as efficient oxygen reduction electrocatalysts for alkaline fuel cells	135
The unequal impact of parenthood in academia	135
Solar-assisted fabrication of large-scale, patternable transparent wood	135
IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis	134
Metasurface enabled quantum edge detection	134

Organic and conservation agriculture promote ecosystem multifunctionality	134
The costs and benefits of primary prevention of zoonotic pandemics	133
Ultrafast, sensitive, and portable detection of COVID-19 IgG using flexible organic electrochemical transistors	133
Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers	133
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8	133
Dynamic structural evolution of iron catalysts involving competitive oxidation and carburization during CO 2 hydrogenation	132
Prospects of halide-based all-solid-state batteries: From material design to practical application	132
Coral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality	132
Ångstrom-scale silver particle–embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation	132
Positive interactions are common among culturable bacteria	132
Extinction and dawn of the modern world in the Carnian (Late Triassic)	131
Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications	131
A flexible multiplexed immunosensor for point-of-care in situ wound monitoring	130
Ionizable lipid nanoparticles for in utero mRNA delivery	130
Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs	130
Digital light processing of liquid crystal elastomers for self-sensing artificial muscles	130
Temperature dependence of elastic and plastic deformation behavior of a refractory high-entropy alloy	129
Intrinsically stretchable electronics with ultrahigh deformability to monitor dynamically moving organs	128
Carbon-free and binder-free Li-Al alloy anode enabling an all-solid-state Li-S battery with high energy and stability	128
Charged skyrmions and topological origin of superconductivity in magic-angle graphene	128
A versatile hydrogel network–repairing strategy achieved by the covalent-like hydrogen bond interaction	127
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response	127
Second life and recycling: Energy and environmental sustainability perspectives for high-performance lithium-ion batteries	127
Spectrally encoded single-pixel machine vision using diffractive networks	127
Exploiting radiative cooling for uninterrupted 24-hour water harvesting from the atmosphere	127
Erosion of global functional diversity across the tree of life	127
The Human Proteoform Project: Defining the human proteome	126
Electronic skin as wireless human-machine interfaces for robotic VR	126
Bioinspired high-power-density strong contractile hydrogel by programmable elastic recoil	126
ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule	126
Revised chronology of central Tibet uplift (Lunpola Basin)	125
The 2021 western North America heat wave among the most extreme events ever recorded globally	125
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures	125
Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches	125
Continuous on-body sensing for the COVID-19 pandemic: Gaps and opportunities	124
Electrically compensated, tattoo-like electrodes for epidermal electrophysiology at scale	124
Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis	124
Competing magnetic phases and fluctuation-driven scalar spin chirality in the kagome metal YMn 6 Sn 6	123
How close are we to the temperature tipping point of the terrestrial biosphere?	123
Wearable plasmonic paper–based microfluidics for continuous sweat analysis	123
Rare earth element mobility in and around carbonatites controlled by sodium, potassium, and silica	122
Biomimetic and flexible piezoelectric mobile acoustic sensors with multiresonant ultrathin structures for machine learning biometrics	122
Amazon rainforest photosynthesis increases in response to atmospheric dryness	122
Acoustofluidic centrifuge for nanoparticle enrichment and separation	122
Evolution and effects of the social-ecological system over a millennium in China’s Loess Plateau	122
An early warning approach to monitor COVID-19 activity with multiple digital traces in near real time	121
Biomineralization: Integrating mechanism and evolutionary history	121
Genetically engineered cell membrane–coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs	121
Extraction of organic chemistry grammar from unsupervised learning of chemical reactions	120
MCART1/SLC25A51 is required for mitochondrial NAD transport	120
Direct and indirect impacts of urbanization on vegetation growth across the world’s cities	120
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity	119
Pooled CRISPR screening identifies m 6 A as a positive regulator of macrophage activation	119
Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light	118
Disparities in dermatology AI performance on a diverse, curated clinical image set	118
Development of ferroelectric nematic fluids with giant-ε dielectricity and nonlinear optical properties	118
The gill-oxygen limitation theory (GOLT) and its critics	118
Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin	118
Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases	118
Understanding the electric and nonelectric field components of the cation effect on the electrochemical CO reduction reaction	118
Psychological inoculation improves resilience against misinformation on social media	117
Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses	117
A mathematical model of ctDNA shedding predicts tumor detection size	117
Orally deliverable strategy based on microalgal biomass for intestinal disease treatment	117
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking	116
Natural climate solutions for Canada	116
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome	116
Asphalt-related emissions are a major missing nontraditional source of secondary organic aerosol precursors	116
Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery	116
A universal wet-chemistry synthesis of solid-state halide electrolytes for all-solid-state lithium-metal batteries	116
Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy	116
Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors	115
Superconductivity in infinite-layer nickelate La 1−x Ca x NiO 2 thin films	115
Spatial and temporal variations in global soil respiration and their relationships with climate and land cover	115
Long-term reliable physical health monitoring by sweat pore–inspired perforated electronic skins	114
A thermal activated and differential self-calibrated flexible epidermal biomicrofluidic device for wearable accurate blood glucose monitoring	114
Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders	114
Strong self-trapping by deformation potential limits photovoltaic performance in bismuth double perovskite	114
Five years of whole-soil warming led to loss of subsoil carbon stocks and increased CO 2 efflux	114
Widespread vulnerability of flowering plant seed production to pollinator declines	114
Highly-integrated, miniaturized, stretchable electronic systems based on stacked multilayer network materials	113
Metal-organic framework enables ultraselective polyamide membrane for desalination and water reuse	113
Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination	113
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay	112
All-weather thermochromic windows for synchronous solar and thermal radiation regulation	112
A pebble accretion model for the formation of the terrestrial planets in the Solar System	112
Design of Ru-Ni diatomic sites for efficient alkaline hydrogen oxidation	111
Analyses of internal structures and defects in materials using physics-informed neural networks	111
Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer	111
Realizing a 14% single-leg thermoelectric efficiency in GeTe alloys	111
CMOS-compatible ferroelectric NAND flash memory for high-density, low-power, and high-speed three-dimensional memory	111
Cryo-shocked cancer cells for targeted drug delivery and vaccination	111
m 6 A demethylase ALKBH5 controls CD4 + T cell pathogenicity and promotes autoimmunity	111
Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy	111
Real-time nanodiamond thermometry probing in vivo thermogenic responses	110