Science Advances

Article	Citations
Discovery of an autoinhibited conformation in mesotrypsin reveals a strategy for selective serine protease inhibition	1563
Anabolic indices of matrix proteins identify regenerative small RNA intrinsic to human cartilage	576
Bone-inspired stress-gaining elastomer enabled by dynamic molecular locking	444
Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk	401
Upward propagation of gigantic jets revealed by 3D radio and optical mapping	357
2D material exciton-polariton transport on 2D photonic crystals	307
Real-time antiproton annihilation vertexing with submicrometer resolution	298
Distinct armchair and zigzag charge transport through single polycyclic aromatics	297
Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function	269
Particle-armored liquid robots	269
Cold exposure stimulates cross-tissue metabolic rewiring to fuel glucose-dependent thermogenesis in brown adipose tissue	267
Multiplexed mapping of the interactome of GPCRs with receptor activity–modifying proteins	263
Mismatched ligand density enables ordered assembly of mixed-dimensional, cross-species materials	262
Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils	258
Spatially resolved single-cell atlas of ascidian endostyle provides insight into the origin of vertebrate pharyngeal organs	255
Enhancer dynamics: Unraveling the mechanism of transcriptional bursting	253
Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy	251
6mA-Sniper: Quantifying 6mA sites in eukaryotes at single-nucleotide resolution	244
GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency	243
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress	243
Predicting three-component reaction outcomes from ~40,000 miniaturized reactant combinations	241
Signatures of speech and song: “Universal” links despite cultural diversity	240
Complementary corticostriatal circuits orchestrate action repetition and switching	239
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety	235
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes	233

Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles	231
The molecular mechanism of sialic acid transport mediated by Sialin	228
Oral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system	227
Editor’s note and erratum for the Research Article: “Unemployment and underemployment are causes of suicide”	224
Biological export production controls upper ocean calcium carbonate dissolution and CO 2 buffer capacity	224
Fast cortical dynamics encode tactile grating orientation during active touch	223
Palimpsest memories stored in memristive synapses	219
Saturn’s F ring is intermittently shepherded by Prometheus	218
Gating of hair cell Ca 2+ channels governs the activity of cochlear neurons	218
Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes	217
Erratum for the Research Article: “SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8 + T cell cytotoxic function” by X. Liu	216
CMOS-compatible electro-optical SRAM cavity device based on negative differential resistance	212
Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration	212
Developmentally programmed histone H3 expression regulates cellular plasticity at the parental-to-early embryo transition	212
Targeting TRPC channels for control of arthritis-induced bone erosion	211
MiniXL: An open-source, large field-of-view epifluorescence miniscope enabling single-cell resolution and multi-region imaging in mice	209
An annually resolved 5700-year storm archive reveals drivers of Caribbean cyclone frequency	208
Unmasking of the von Willebrand A-domain surface adhesin CglB at bacterial focal adhesions mediates myxobacterial gliding motility	207
Dephosphorylation and ion binding in prokaryotic calcium transport	205
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS	205
Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies	203
Tree-ring stable isotopes from the European Alps reveal long-term summer drying over the Holocene	202
Ag-doped non–imperfection-enabled uniform memristive neuromorphic device based on van der Waals indium phosphorus sulfide	202
Pathways to concealed gun carrying	199
Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity	192
Long noncoding RNA DREAMer bridges the DREAM complex and E2f1 to regulate endoreplication in Drosophila	191
Optimizing the timing of an end-of-outbreak declaration: Ebola virus disease in the Democratic Republic of the Congo	190
Cpeb1 remodels cell type–specific translational program to promote fear extinction	189
Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions	189
Inflammatory responses to acute carbon monoxide poisoning and the role of plasma gelsolin	189
Erratum for the Research Article: “Oscillation of type IV pili regulated by the circadian clock in cyanobacterium Synechococcus elongatus PCC7942” by Zhang <	188
Microsecond dynamics control the HIV-1 Envelope conformation	188
Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding	186
Erratum for the Research Article: “TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma” by Sun et al .	183
Considering intentional stratospheric dehydration for climate benefits	183
Quantized critical supercurrent in SrTiO 3 -based quantum point contacts	180
Broadband photodetection of intense lasers via exciton-enhanced high-order multiphoton-absorption optoelectronics in 2D hybrid perovskite	180
Daily turnover of active giant virus infection during algal blooms revealed by single-cell transcriptomics	180
Diversification of the ruminant skull along an evolutionary line of least resistance	180
Pancreatic tumor microenvironmental acidosis and hypoxia transform gold nanorods into cell-penetrant particles for potent radiosensitization	178
Real-time observation of non-equilibrium phonon-electron energy and angular momentum flow in laser-heated nickel	177
Electrostatic nano-mask patterned 180° domain walls in a ferroelectric film	176
A molecular switch controls assembly of bacterial focal adhesions	175
The super elongation complex drives transcriptional addiction in MYCN -amplified neuroblastoma	174
The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation	174
Driving forces of Antarctic krill abundance	173
Small effect of partial melt on electrical anomalies in the asthenosphere	172
The cohesin stabilizer Sororin drives G 2 -M transition and spindle assembly in mammalian oocytes	172
Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic	171
Overexpression of the scopoletin biosynthetic pathway enhances lignocellulosic biomass processing	170

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex	170
Observation of dynamic nuclear polarization echoes	170
Compressing slippery surface-assembled amphiphiles for tunable haptic energy harvesters	170
Buffering of genetic dominance by allele-specific protein complex assembly	167
Erratum for the Research Article: “Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell”	167
Genome wide nucleosome landscape shapes 3D chromatin organization	166
How genomic insights into the evolutionary history of clouded leopards inform their conservation	164
Episodic reef growth in the Last Interglacial driven by competing influence of polar ice sheets to sea level rise	161
Ancient genomes reveal Avar-Hungarian transformations in the 9th-10th centuries CE Carpathian Basin	160
A two-stage mantle plume-sagduction origin of Archean continental crust revealed by water and oxygen isotopes of TTGs	160
Analysis of sloppiness in model simulations: Unveiling parameter uncertainty when mathematical models are fitted to data	159
A conserved molecular template underlies color pattern diversity in estrildid finches	159
A computational mechanism of cue-stimulus integration for pain in the brain	159
Distributed interfacing by nanoscale photodiodes enables single-neuron light activation and sensory enhancement in 3D spinal explants	157
Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis	157
Elucidating the characteristics and clonal evolutionary trajectory of influenza neuraminidase broadly reactive B cell	156
Inherent tendency of Synechococcus and heterotrophic bacteria for mutualism on long-term coexistence despite environmental interference	156
VARP binds SNX27 to promote endosomal supercomplex formation on membranes	156
Emergence and reconfiguration of modular structure for artificial neural networks during continual familiarity detection	153
Tailoring sub-3.3 Å ultramicropores in advanced carbon molecular sieve membranes for blue hydrogen production	153
Sensory-motor circuit is a therapeutic target for dystonia musculorum mice, a model of hereditary sensory and autonomic neuropathy 6	151
Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation fea	150
Non-adapted bacterial infection suppresses plant reproduction	149
Engineering edgeless human skin with enhanced biomechanical properties	148
A radio pulsar phase from SGR J1935+2154 provides clues to the magnetar FRB mechanism	148
The synovial environment steers cartilage deterioration and regeneration	148
Phylogenetic tracing of midbrain-specific regulatory sequences suggests single origin of eubilaterian brains	147
The extinct shark Otodus megalodon was a transoceanic superpredator: Inferences from 3D modeling	146
Time-resolving state-specific molecular dissociation with XUV broadband absorption spectroscopy	146
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions	145
Convergent consequences of parthenogenesis on stick insect genomes	145
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 + T cell responses	145
Abiotic molecular oxygen production—Ionic pathway from sulfur dioxide	144
Diamond-based microwave quantum amplifier	144
Motion Hologram: Jointly optimized hologram generation and motion planning for photorealistic 3D displays via reinforcement learning	143
Sensing spin wave excitations by spin defects in few-layer-thick hexagonal boron nitride	142
In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI	142
Hidden white and black feather layers enhance plumage coloration in tanagers and other songbirds	141
Donor HLA-DQ genetic and functional divergence affect the control of BK polyoma virus infection after kidney transplantation	141
Low-dose metformin requires brain Rap1 for its antidiabetic action	141
Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration	140
Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization	140
27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior	140
DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga	140
DNA damage response pathway regulates Nrf2 in response to oxidative stress	140
Global health risks lurking in livestock resistome	140
Deep and dynamic metabolic and structural imaging in living tissues	139
Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk	139
Multiplexed CRISPR-Cas9 mutagenesis of rice PSBS1 noncoding sequences for transgene-free overexpression	139
Quantifying structural relationships of metal-binding sites suggests origins of biological electron transfer	139
Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells	137
Fluid dynamical pathways of airborne transmission while waiting in a line	136
Diurnal urban rainfall anomalies across different landscapes	136
Shear shock waves mediate haptic holography via focused ultrasound	136
Ultrafast tomograms in a flash	136
Underwater metamaterial absorber with impedance-matched composite	136
Identification of the Wnt signal peptide that directs secretion on extracellular vesicles	136
Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy	135
Miniature color camera via flat hybrid meta-optics	135
Direct observations of cross-scale wave-particle energy transfer in space plasmas	134
An artificial sodium-selective subnanochannel	134
Comediation of voltage gating and ion charge in MXene membrane for controllable and selective monovalent cation separation	134
Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis	134
Fungal-fungal cocultivation leads to widespread secondary metabolite alteration requiring the partial loss-of-function VeA1 protein	134
Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system	134
Optical control of 4 f orbital state in rare-earth metals	132
Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting	131
Elder fish means more microplastics? Alaska pollock microplastic story in the Bering Sea	131
Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis	131
Significant loophole-free test of Kochen-Specker contextuality using two species of atomic ions	131
A monolayer crystalline covalent network of polyoxometalate clusters	131
HfZrO-based synaptic resistor circuit for a Super-Turing intelligent system	130
A closed-loop catalytic nanoreactor system on a transistor	130
High coherence and low cross-talk in a tileable 3D integrated superconducting circuit architecture	130
Volcanic CO 2 tracks the incubation period of basaltic paroxysms	130
Subcellular organization of viral particles during maturation of nucleus-forming jumbo phage	130
Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos	129
Experimental evidence for long-distance electrodynamic intermolecular forces	129
Designing a DNA synchronizer for compact single-rail DNA logic circuits	129
Spiral self-assembly of lamellar micelles into multi-shelled hollow nanospheres with unique chiral architecture	129

Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions	128
Truncated jarid2 and kdm6b transcripts are associated with temperature-induced sex reversal during development in a dragon lizard	127
The genomic landscape of familial glioma	127
Valence electron concentration as key parameter to control the fracture resistance of refractory high-entropy carbides	126
Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity	125
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury	125
Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct	125
Mechanical tension mobilizes Lgr6 + epidermal stem cells to drive skin growth	124
Anthropogenic warming has ushered in an era of temperature-dominated droughts in the western United States	124
Uncertainties too large to predict tipping times of major Earth system components from historical data	124
Neuromuscular embodiment of feedback control elements in Drosophila flight	124
Magnetic fields and relativistic electrons fill entire galaxy cluster	123
Multicatalysis protocol enables direct and versatile enantioselective reductive transformations of secondary amides	123
Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by f	123
Memristive floating-point Fourier neural operator network for efficient scientific modeling	123
Separation and recycling of hydrofluorocarbon refrigerant mixtures with fluoropolymer-coated hollow fiber membranes	123
The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat	122
Maternal chemosignals enhance infant-adult brain-to-brain synchrony	122
A DNA circuit that records molecular events	122
Early Middle Stone Age personal ornaments from Bizmoune Cave, Essaouira, Morocco	122
Attentional guidance through object associations in visual cortex	122
Rising dissolved organic carbon concentrations in coastal waters of northwestern Borneo related to tropical peatland conversion	122
Engineering is pregnant with possibilities	121
N -Heterocyclic carbene catalytic 1,2-boron migrative acylation accelerated by photocatalysis	121
X-ray phase measurements by time-energy correlated photon pairs	121
Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with reactivation routes and potential	121
Laws about bodily damage originate from shared intuitions about the value of body parts	120
Dynamic phase transitions dictate the size effect and activity of supported gold catalysts	120
Real-space investigation of polarons in hematite Fe 2 O 3	120
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ	119
Biological self-protection inspired engineering of nanomaterials to construct a robust bio-nano system for environmental applications	119
Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer	119
Autocatalytic assembly of a chimeric aminoacyl-RNA synthetase ribozyme	119
Metasurface-based realization of photonic time crystals	118
Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy	118
Rhombohedral-stacked bilayer transition metal dichalcogenides for high-performance atomically thin CMOS devices	118
Ocean-induced melt volume directly paces ice loss from Pine Island Glacier	118
Focusing of in-plane hyperbolic polaritons in van der Waals crystals with tailored infrared nanoantennas	118
Injectable shear-thinning hydrogels promote oligodendrocyte progenitor cell survival and remyelination in the central nervous system	118
Seeing through arthropod eyes: An AI-assisted, biomimetic approach for high-resolution, multi-task imaging	118
Articular fibrocartilage-targeted therapy by microtubule stabilization	118
Diving into the vertical dimension of elasmobranch movement ecology	117
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry	116
Quantum imaging of biological organisms through spatial and polarization entanglement	116
Ordered planar plating/stripping enables deep cycling zinc metal batteries	116
Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments	116
Transcriptional regulation of photoprotection in dark-to-light transition—More than just a matter of excess light energy	116
All eukaryotic SMC proteins induce a twist of −0.6 at each DNA loop extrusion step	115
Pd/Xu-Phos-catalyzed asymmetric elimination of fully substituted enol triflates into axially chiral trisubstituted allenes	115
Multi-stimulus perception and visualization by an intelligent liquid metal-elastomer architecture	115
A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration	115
Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5	114
Structure and electron transfer pathways of an electron-bifurcating NiFe-hydrogenase	114
High-throughput production of kilogram-scale nanofibers by Kármán vortex solution blow spinning	114
Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters	114
Structure and dynamics determine G protein coupling specificity at a class A GPCR	114
Invariable resistance of conductive nanocomposite over 30% strain	114
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology	113
Increasing co-occurrence of fine particulate matter and ground-level ozone extremes in the western United States	113
Liquid palladium for high-turnover carbon-carbon bond formation	113
A printed luminescent flier inspired by plant seeds for eco-friendly physical sensing	112
Molybdate uptake interplay with ROS tolerance modulates bacterial pathogenesis	112
Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching	112
Distributed sensing along fibers for smart clothing	112
Quantum imaging of the reconfigurable VO 2 synaptic electronics for neuromorphic computing	111
Rare earth elements from waste	111
Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses	111
Predicting master transcription factors from pan-cancer expression data	111
Phyto-inspired sustainable and high-performance fabric generators via moisture absorption-evaporation cycles	111
An outsized role for the Labrador Sea in the multidecadal variability of the Atlantic overturning circulation	111
Miniature battery-free epidural cortical stimulators	111
Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury	110
Imaging local diffusion in microstructures using NV-based pulsed field gradient NMR	110
Prebunking and credible source corrections increase election credibility: Evidence from the US and Brazil	110
Schrödinger’s red pixel by quasi-bound-states-in-the-continuum	110
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control	110
A stretchable and strain-unperturbed pressure sensor for motion interference–free tactile monitoring on skins	110
Oxygen isotopes of anhydrous primary minerals show kinship between asteroid Ryugu and comet 81P/Wild2	110
On-demand modulating afterglow color of water-soluble polymers through phosphorescence FRET for multicolor security printing	109
Bound chiral magnonic polariton states for ideal microwave isolation	109
If you rise, I fall: Equality is prevented by the misperception that it harms advantaged groups	109
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization	109
Spinning and corkscrewing of oceanic macroplankton revealed through in situ imaging	109
Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target	108
3D DNA origami pincers that multitask on giant unilamellar vesicles	108
Biodegradable electrospinning superhydrophilic nanofiber membranes for ultrafast oil-water separation	107
Symmetry disruption commits vault particles to disassembly	107
LC3-associated endocytosis and the functions of Rubicon and ATG16L1	107
Alcaligenes faecalis corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds	107
Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation	107
Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs	107
Gender composition predicts gender bias: A meta-reanalysis of hiring discrimination audit experiments	107
Hierarchical twinning governed by defective twin boundary in metallic materials	107
Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases	106
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis	106