Science Advances

Article	Citations
A single–cell type transcriptomics map of human tissues	852
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening	792
Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis	688
More than 1000 rivers account for 80% of global riverine plastic emissions into the ocean	602
Earth beyond six of nine planetary boundaries	574
Agricultural diversification promotes multiple ecosystem services without compromising yield	494
High-entropy materials for catalysis: A new frontier	411
PM 2.5 polluters disproportionately and systemically affect people of color in the United States	354
CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy	316
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM	308
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L	303
Falling living standards during the COVID-19 crisis: Quantitative evidence from nine developing countries	302
3D printing of highly stretchable hydrogel with diverse UV curable polymers	292
Plastic waste to fuels by hydrocracking at mild conditions	279
23.7% Efficient inverted perovskite solar cells by dual interfacial modification	278
Vaccine optimization for COVID-19: Who to vaccinate first?	277
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation	274
Learning the solution operator of parametric partial differential equations with physics-informed DeepONets	263
The direct drivers of recent global anthropogenic biodiversity loss	256
Controlling electrochemical growth of metallic zinc electrodes: Toward affordable rechargeable energy storage systems	253
A highly stable lithium metal anode enabled by Ag nanoparticle–embedded nitrogen-doped carbon macroporous fibers	250
Abrupt but smaller than expected changes in surface air quality attributable to COVID-19 lockdowns	239
A unified vegetation index for quantifying the terrestrial biosphere	239
Bioinspired mechano-photonic artificial synapse based on graphene/MoS 2 heterostructure	234
Long-term (1990–2019) monitoring of forest cover changes in the humid tropics	229

In-sensor reservoir computing for language learning via two-dimensional memristors	228
Efficient and stable inverted perovskite solar cells with very high fill factors via incorporation of star-shaped polymer	226
High-performance wearable thermoelectric generator with self-healing, recycling, and Lego-like reconfiguring capabilities	223
Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration	217
Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants	215
Mixed-dimensional MXene-hydrogel heterostructures for electronic skin sensors with ultrabroad working range	214
Recycling of multilayer plastic packaging materials by solvent-targeted recovery and precipitation	214
Ultrasound Doppler-guided real-time navigation of a magnetic microswarm for active endovascular delivery	212
Direct detection of circular polarized light in helical 1D perovskite-based photodiode	209
Ultrahigh specific strength in a magnesium alloy strengthened by spinodal decomposition	208
Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders	206
Exposing unsaturated Cu 1 -O 2 sites in nanoscale Cu-MOF for efficient electrocatalytic hydrogen evolution	205
Conductance-stable liquid metal sheath-core microfibers for stretchy smart fabrics and self-powered sensing	203
Molecularly soldered covalent organic frameworks for ultrafast precision sieving	202
From room temperature to harsh temperature applications: Fundamentals and perspectives on electrolytes in zinc metal batteries	201
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm	199
Iodine reduction for reproducible and high-performance perovskite solar cells and modules	197
Environmental exposure enhances the internalization of microplastic particles into cells	196
Slot-die coating large-area formamidinium-cesium perovskite film for efficient and stable parallel solar module	195
Intrapore energy barriers govern ion transport and selectivity of desalination membranes	195
Stimulus-responsive room temperature phosphorescence materials with full-color tunability from pure organic amorphous polymers	193
Crystallization in one-step solution deposition of perovskite films: Upward or downward?	192
Metal-metal interactions in correlated single-atom catalysts	191
Class I histone deacetylases (HDAC1–3) are histone lysine delactylases	191
Differential effects of intervention timing on COVID-19 spread in the United States	190
Metasurface-based key for computational imaging encryption	189
Confining Sn nanoparticles in interconnected N-doped hollow carbon spheres as hierarchical zincophilic fibers for dendrite-free Zn metal anodes	188
Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels	188
A smartphone-read ultrasensitive and quantitative saliva test for COVID-19	187
Optical secret sharing with cascaded metasurface holography	186
Self-powered electro-tactile system for virtual tactile experiences	184
Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces	184
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer	183
Scalable integrated single-photon source	182
An ultrathin rechargeable solid-state zinc ion fiber battery for electronic textiles	182
Meta-optics achieves RGB-achromatic focusing for virtual reality	181
Standalone real-time health monitoring patch based on a stretchable organic optoelectronic system	181
A stretchable and strain-unperturbed pressure sensor for motion interference–free tactile monitoring on skins	176
A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics	176
Highly selective and high-performance osmotic power generators in subnanochannel membranes enabled by metal-organic frameworks	176
Plant rhizodeposition: A key factor for soil organic matter formation in stable fractions	176
Soft robotic origami crawler	176
Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity	174
Holographic metasurface gas sensors for instantaneous visual alarms	173
Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver	171
A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics	169
Changes in global terrestrial live biomass over the 21st century	169
Artificial tactile perception smart finger for material identification based on triboelectric sensing	169
LRRK2 mediates tubulation and vesicle sorting from lysosomes	168
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality	168

Deep learning model to predict complex stress and strain fields in hierarchical composites	167
Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets	166
Systemic inequalities for LGBTQ professionals in STEM	164
Single-site Pt-doped RuO 2 hollow nanospheres with interstitial C for high-performance acidic overall water splitting	164
Indium-antimony-halide single crystals for high-efficiency white-light emission and anti-counterfeiting	163
Engendering persistent organic room temperature phosphorescence by trace ingredient incorporation	162
Nonvolatile programmable silicon photonics using an ultralow-loss Sb 2 Se 3 phase change material	162
Amorphization in extreme deformation of the CrMnFeCoNi high-entropy alloy	159
Hydroplastic foaming of graphene aerogels and artificially intelligent tactile sensors	159
Two-qubit silicon quantum processor with operation fidelity exceeding 99%	159
A clicking confinement strategy to fabricate transition metal single-atom sites for bifunctional oxygen electrocatalysis	159
Comprehensive analysis of spatial architecture in primary liver cancer	158
The carrier transition from Li atoms to Li vacancies in solid-state lithium alloy anodes	158
Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids	157
Sequential vacuum-evaporated perovskite solar cells with more than 24% efficiency	155
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression	155
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring	155
Crowdsourced air temperatures contrast satellite measures of the urban heat island and its mechanisms	153
Spatial heterogeneity and environmental predictors of permafrost region soil organic carbon stocks	152
Untethered small-scale magnetic soft robot with programmable magnetization and integrated multifunctional modules	151
Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations	151
Blackbody-sensitive room-temperature infrared photodetectors based on low-dimensional tellurium grown by chemical vapor deposition	149
Amorphization mechanism of SrIrO 3 electrocatalyst: How oxygen redox initiates ionic diffusion and structural reorganization	149
Satellite-based estimates of decline and rebound in China’s CO 2 emissions during COVID-19 pandemic	149
Ultrastrong lightweight compositionally complex steels via dual-nanoprecipitation	149
Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing	149
Hierarchically porous polyimide/Ti 3 C 2 T x film with stabl	149
Partisan pandemic: How partisanship and public health concerns affect individuals’ social mobility during COVID-19	148
On-demand modulating afterglow color of water-soluble polymers through phosphorescence FRET for multicolor security printing	148
100,000-spin coherent Ising machine	146
YAP-mediated mechanotransduction tunes the macrophage inflammatory response	146
Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality	145
Increasing precipitation variability on daily-to-multiyear time scales in a warmer world	145
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome	145
Multilayered electronic transfer tattoo that can enable the crease amplification effect	144
Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis	142
Global waves synchronize the brain’s functional systems with fluctuating arousal	141
ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus –infected chronic skin wound healing	141
Organic and conservation agriculture promote ecosystem multifunctionality	140
Dynamic structural evolution of iron catalysts involving competitive oxidation and carburization during CO 2 hydrogenation	140
The unequal impact of parenthood in academia	139
Metasurface enabled quantum edge detection	138
Prospects of halide-based all-solid-state batteries: From material design to practical application	138
Solar-assisted fabrication of large-scale, patternable transparent wood	137
Positive interactions are common among culturable bacteria	137
Digital light processing of liquid crystal elastomers for self-sensing artificial muscles	136
Heterogeneous integration of rigid, soft, and liquid materials for self-healable, recyclable, and reconfigurable wearable electronics	136
The costs and benefits of primary prevention of zoonotic pandemics	136
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8	136
Ultrafast, sensitive, and portable detection of COVID-19 IgG using flexible organic electrochemical transistors	135
IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis	135
The SARS-CoV-2 Spike variant D614G favors an open conformational state	135
Nonprecious transition metal nitrides as efficient oxygen reduction electrocatalysts for alkaline fuel cells	135
The 2021 western North America heat wave among the most extreme events ever recorded globally	134
A flexible multiplexed immunosensor for point-of-care in situ wound monitoring	134
A versatile hydrogel network–repairing strategy achieved by the covalent-like hydrogen bond interaction	134
Coral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality	134
Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications	133
Charged skyrmions and topological origin of superconductivity in magic-angle graphene	133
Ionizable lipid nanoparticles for in utero mRNA delivery	133
Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs	133
Carbon-free and binder-free Li-Al alloy anode enabling an all-solid-state Li-S battery with high energy and stability	132
The Human Proteoform Project: Defining the human proteome	130
Electronic skin as wireless human-machine interfaces for robotic VR	130
Second life and recycling: Energy and environmental sustainability perspectives for high-performance lithium-ion batteries	129
Spectrally encoded single-pixel machine vision using diffractive networks	129
Intrinsically stretchable electronics with ultrahigh deformability to monitor dynamically moving organs	129
Exploiting radiative cooling for uninterrupted 24-hour water harvesting from the atmosphere	128
Biomineralization: Integrating mechanism and evolutionary history	128
Bioinspired high-power-density strong contractile hydrogel by programmable elastic recoil	128
Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer’s patches	128
Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis	128
Revised chronology of central Tibet uplift (Lunpola Basin)	128
Erosion of global functional diversity across the tree of life	127
Disparities in dermatology AI performance on a diverse, curated clinical image set	127
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures	127
Wearable plasmonic paper–based microfluidics for continuous sweat analysis	127
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response	127
How close are we to the temperature tipping point of the terrestrial biosphere?	126
Extraction of organic chemistry grammar from unsupervised learning of chemical reactions	125

Pooled CRISPR screening identifies m 6 A as a positive regulator of macrophage activation	125
Acoustofluidic centrifuge for nanoparticle enrichment and separation	125
Biomimetic and flexible piezoelectric mobile acoustic sensors with multiresonant ultrathin structures for machine learning biometrics	125
Competing magnetic phases and fluctuation-driven scalar spin chirality in the kagome metal YMn 6 Sn 6	124
Amazon rainforest photosynthesis increases in response to atmospheric dryness	124
An early warning approach to monitor COVID-19 activity with multiple digital traces in near real time	124
Development of ferroelectric nematic fluids with giant-ε dielectricity and nonlinear optical properties	122
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity	122
Genetically engineered cell membrane–coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs	122
Orally deliverable strategy based on microalgal biomass for intestinal disease treatment	121
Direct and indirect impacts of urbanization on vegetation growth across the world’s cities	121
Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases	121
Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery	121
Analyses of internal structures and defects in materials using physics-informed neural networks	120
Understanding the electric and nonelectric field components of the cation effect on the electrochemical CO reduction reaction	120
Five years of whole-soil warming led to loss of subsoil carbon stocks and increased CO 2 efflux	119
Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light	119
Psychological inoculation improves resilience against misinformation on social media	119
Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders	119
A pebble accretion model for the formation of the terrestrial planets in the Solar System	118
The gill-oxygen limitation theory (GOLT) and its critics	118
Superconductivity in infinite-layer nickelate La 1−x Ca x NiO 2 thin films	118
A universal wet-chemistry synthesis of solid-state halide electrolytes for all-solid-state lithium-metal batteries	117
Strong self-trapping by deformation potential limits photovoltaic performance in bismuth double perovskite	117
Natural climate solutions for Canada	117
Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses	117
A mathematical model of ctDNA shedding predicts tumor detection size	117
Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors	116
Widespread vulnerability of flowering plant seed production to pollinator declines	116
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome	116
Highly-integrated, miniaturized, stretchable electronic systems based on stacked multilayer network materials	116
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking	116
CMOS-compatible ferroelectric NAND flash memory for high-density, low-power, and high-speed three-dimensional memory	116
Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy	116
Design of Ru-Ni diatomic sites for efficient alkaline hydrogen oxidation	115
A thermal activated and differential self-calibrated flexible epidermal biomicrofluidic device for wearable accurate blood glucose monitoring	115
Metal-organic framework enables ultraselective polyamide membrane for desalination and water reuse	115
What fuels the fly: Energy metabolism in Drosophila and its application to the study of obesity and diabetes	115
Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination	114
Cryo-shocked cancer cells for targeted drug delivery and vaccination	114
All-weather thermochromic windows for synchronous solar and thermal radiation regulation	114
m 6 A demethylase ALKBH5 controls CD4 + T cell pathogenicity and promotes autoimmunity	114
Long-term reliable physical health monitoring by sweat pore–inspired perforated electronic skins	114
Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy	113
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay	112
TCR-engineered T cell therapy in solid tumors: State of the art and perspectives	112
Giant negative thermopower of ionic hydrogel by synergistic coordination and hydration interactions	112
Protecting ice from melting under sunlight via radiative cooling	112
In situ stiffness manipulation using elegant curved origami	111
Realizing a 14% single-leg thermoelectric efficiency in GeTe alloys	111
Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer	111
Fully recyclable multifunctional adhesive with high durability, transparency, flame retardancy, and harsh-environment resistance	111
MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program	111
Global homogenization of the structure and function in the soil microbiome of urban greenspaces	111
Topology-dependent asymmetry in systematic errors affects phylogenetic placement of Ctenophora and Xenacoelomorpha	110
Deformation-induced crystalline-to-amorphous phase transformation in a CrMnFeCoNi high-entropy alloy	110
Increasing forest fire emissions despite the decline in global burned area	110
Room temperature coherent control of spin defects in hexagonal boron nitride	110
Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system	110
Deeply conserved synteny and the evolution of metazoan chromosomes	109
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease	109
Toward the capacity limit of 2D planar Jones matrix with a single-layer metasurface	109
Gradient bimetallic ion–based hydrogels for tissue microstructure reconstruction of tendon-to-bone insertion	109
A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease	109
An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants	108
Hidden destruction of older forests threatens Brazil’s Atlantic Forest and challenges restoration programs	108
Species richness stabilizes productivity via asynchrony and drought-tolerance diversity in a large-scale tree biodiversity experiment	108
Chemical anti-corrosion strategy for stable inverted perovskite solar cells	108
A thin, deformable, high-performance supercapacitor implant that can be biodegraded and bioabsorbed within an animal body	107
A fully biodegradable and self-electrified device for neuroregenerative medicine	107
Ultrabright Au@Cu 14 nanoclusters: 71.3% phosphorescence quantum yield in non-degassed solution at room temperature	107
Bridging-induced phase separation induced by cohesin SMC protein complexes	106
Oldest cave art found in Sulawesi	106
A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds	106
A solid-to-solid metallic conversion electrochemistry toward 91% zinc utilization for sustainable aqueous batteries	106
Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study	105
Peer review and gender bias: A study on 145 scholarly journals	105
Direct coherent multi-ink printing of fabric supercapacitors	105
The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway	105
Multicolor three-photon fluorescence imaging with single-wavelength excitation deep in mouse brain	105
Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy	104
Excess of COVID-19 cases and deaths due to fine particulate matter exposure during the 2020 wildfires in the United States	104
Membrane-confined liquid-liquid phase separation toward artificial organelles	104
Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129 Xe MRI	104
Making climate projections conditional on historical observations	103
U.S. fires became larger, more frequent, and more widespread in the 2000s	103
Discretely assembled mechanical metamaterials	103
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity	103
ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation	102
Learning hierarchical sequence representations across human cortex and hippocampus	102
Overfishing and habitat loss drive range contraction of iconic marine fishes to near extinction	101
Intrinsically stretchable organic light-emitting diodes	101
Breakthrough treatments for accelerated wound healing	101
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease	101
Modern human incursion into Neanderthal territories 54,000 years ago at Mandrin, France	101