ACS Central Science

Papers
(The median citation count of ACS Central Science is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)
ArticleCitations
Alexandrian Cut in Downstream Lignin Valorization to Yield Novel Plasticizers254
Chasing Waterfalls: A Cascade Mechanism to Generate Triplets from 2 LMCT States188
ACS Central Science: Embracing Breadth in Scope and Scientific Topical Representation153
Pumping Iron for Tuberculosis Diagnostics136
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A Conversation with Elaine Bearer, Neuropathologist133
Stationary DNA Origami Register Drives Fast Sequential DNA Computing132
Mesoporous Potassium-Based Metal–Organic Framework as a Drug Carrier123
Spiro-strain Takes Chemiluminescence to Flash-Mode122
Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products112
Rational Vaccinology: Harnessing Nanoscale Chemical Design for Cancer Immunotherapy107
Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability104
Correspondence on “An International Study Evaluating Elemental Analysis”97
Manipulating Tyrosine Phosphorylation by Heterobifunctional Small Molecules97
Dynamically Interacting Protein Networks Provide a Mechanism to Overcome the Enormous Intrinsic Barrier to Orotidine 5′-Monophosphate Decarboxylation96
A Small Molecule Drug-Based Ru(II) Polypyridine Mass-Tag for Multimodal Imaging of Tissue Samples93
A Sample-Centric and Knowledge-Driven Computational Framework for Natural Products Drug Discovery92
Intracellular Relaxometry, Challenges, and Future Directions91
Interrogating RNA–Small Molecule Interactions with Structure Probing and Artificial Intelligence-Augmented Molecular Simulations83
Ultra-High Purity and Productivity Separation of CO2 and C2H2 from CH4 in Rigid Layered Ultramicroporous Material82
PEARL-Catalyzed Peptide Bond Formation after Chain Reversal by Ureido-Forming Condensation Domains80
Regulation of Calcium Ion Channels with Conjugated Molecules for Modulating Biological Functions80
Promoting CO2 Electroreduction to Acetate by an Amine-Terminal, Dendrimer-Functionalized Cu Catalyst78
Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome77
Creation of Cationic Polymeric Nanotrap Featuring High Anion Density and Exceptional Alkaline Stability for Highly Efficient Pertechnetate Removal from Nuclear Waste Streams76
A Regiospecific Co-Assembly Method to Functionalize Ordered Mesoporous Metal Oxides with Customizable Noble Metal Nanocrystals76
Researchers Face Challenges Devising a PFAS-Free Future74
The Fight Against Frostbite Progresses74
Unlocking Efficient O2 Electroreduction in Conductive MOFs via Enhanced Mass Transport70
Bioorthogonal Chemical Ligation Creates Synthetic Antibodies with Improved Therapeutic Potency68
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Click Chemistry Selectively Activates an Auristatin Protodrug with either Intratumoral or Systemic Tumor-Targeting Agents65
Surface Curvature Matters in Electrochemical Reactions65
Directed Gas-Phase Formation of Azulene (C10H8): Unraveling the Bottom-Up Chemistry of Saddle-Shaped Aromatics64
Plug Flow: Generating Renewable Electricity with Water from Nature by Breaking the Limit of Debye Length63
Plastic Pores for Switchable and Optimized Adsorption Behaviors63
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury63
Inserting Three-Coordinate Nickel into [4Fe-4S] Clusters62
A Long-Lost Coffee Bean Tastes as Good as the Best─To Understand Why, Scientists Turn to Chemistry62
Scientists Are Engineering Asphalt That Is Safer for Humans and the Environment61
A Conversation with Carolyn Pearce58
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Entropy Drives the Predictive Discovery of an Optimal Cleavable Comonomer for ROMP57
Mechanism of O2 Activation and Cysteine Oxidation by the Unusual Mononuclear Cu(I) Active Site of the Formylglycine-Generating Enzyme57
Anomalous Interfacial Electron-Transfer Kinetics in Twisted Trilayer Graphene Caused by Layer-Specific Localization56
Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa -Opioid Receptor Agonism56
Activity-Based NIR Bioluminescence Probe Enables Discovery of Diet-Induced Modulation of the Tumor Microenvironment via Nitric Oxide56
Nickel-Catalyzed Enantio- and Diastereoselective Synthesis of Fluorine-Containing Vicinal Stereogenic Centers53
Engineering the ChlorON Series: Turn-On Fluorescent Protein Sensors for Imaging Labile Chloride in Living Cells51
Transforming Aluminum-Ion Batteries with Recyclable Solid-State Electrolytes51
Dihydroxy-Metabolites of Dihomo-γ-linolenic Acid Drive Ferroptosis-Mediated Neurodegeneration49
Synthesis and Single Crystal X-ray Diffraction Structure of an Indium Arsenide Nanocluster48
Scaling Organic Electrosynthesis: The Crucial Interplay between Mechanism and Mass Transport48
Sugar Wars: Formulators of Endurance Fuels Compete to Pack More Energy in Fewer Molecules47
Keys to Unravel the Stability/Durability Issues of Platinum-Group-Metal Catalysts toward Oxygen Evolution Reaction for Acidic Water Splitting47
Issue Editorial Masthead47
Triplet Photosensitized para-Hydrogen Induced Polarization46
Gemini Amphiphiles: Robust Cytosolic Delivery of Therapeutic Biomacromolecules through Non-Endocytic Translocation Pathways46
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Rieske Oxygenase Catalyzed C–H Bond Functionalization Reactions in Chlorophyll b Biosynthesis45
Organic Reactivity Made Easy and Accurate with Automated Multireference Calculations45
Dual-Wavelength Simultaneous Patterning of Degradable Thermoset Supports for One-Pot Embedded 3D Printing44
Phosphates as Assisting Groups in Glycan Synthesis44
Addition and Correction to “High-Performance Concurrent Chemo-Immuno-Radiotherapy for the Treatment of Hematologic Cancer through Selective High-Affinity Ligand Antibody Mimic-Functionalized Doxorubic44
Powerful Avidity with a Limited Valency for Virus-Attachment Blockers on DC-SIGN: Combining Chelation and Statistical Rebinding with Structural Plasticity of the Receptor44
Intersubunit Coupling Enables Fast CO2-Fixation by Reductive Carboxylases44
Isopotential Electron Titration: Hydrogen Adsorbate-Metal Charge Transfer43
A Quantum Compass for Materials Discovery: Navigating the Combinatorial Explosion43
Diverse Superatomic Magnetic and Spin Properties of Au144(SC8H9)60 Clusters43
Landing Proteins on Graphene Trampoline Preserves Their Gas-Phase Folding on the Surface43
High-Throughput 19F NMR Chiral Analysis for Screening and Directed Evolution of Imine Reductases42
Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous Alkanes Enabled by Hydrogen Atom Transfer in Flow41
Turn up the Vitamin D Receptor─Not the Calcium! Photoswitchable Vitamin D Agonists for Psoriasis41
A Roadmap for Efficient and Stable All-Perovskite Tandem Solar Cells from a Chemistry Perspective41
Manipulation of Shallow-Trap States in Halide Double Perovskite Enables Real-Time Radiation Dosimetry40
Human–Machine Collaboration for Accelerated Discovery of Promising Oxygen Evolution Electrocatalysts with On-Demand Elements40
Manganese Promoted (Bi)carbonate Hydrogenation and Formate Dehydrogenation: Toward a Circular Carbon and Hydrogen Economy40
Tumor Metabolism-Rewriting Nanomedicines for Cancer Immunotherapy39
Thousand-fold increase in O2 electroreduction rates with conductive MOFs39
A Unified Description of Salt Effects on the Liquid–Liquid Phase Separation of Proteins38
Direct and Indirect Pathways of CdTeSe Magic-Size Cluster Isomerization Induced by Surface Ligands at Room Temperature38
Microbial Upcycling of Waste PET to Adipic Acid38
Catalytic Asymmetric Synthesis of Tröger’s Base Analogues with Nitrogen Stereocenter38
A Triple-Targeted Rutin-Based Self-Assembled Delivery Vector for Treating Ischemic Stroke by Vascular Normalization and Anti-Inflammation via ACE2/Ang1-7 Signaling38
Unveiling the Structure of Anhydrous Sodium Valproate with 3D Electron Diffraction and a Facile Sample Preparation Workflow38
Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson’s Disease37
Herbicides─Unexpected Allies against Invasive Plants37
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Design and Development of an Organocatalyst for Light Accelerated Amide and Peptide Synthesis37
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Opening the Door to New Design Rules for Rechargeable Battery Materials37
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A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System35
Toward In Silico Design of Protein–Protein Interaction Stabilizers35
Spatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures35
Beyond Common Energy Transfer: Intramolecular Electron Transfer Cascade Controls Triplet Population of a Long-Lived Iron-Anthracene Molecular Dyad35
Illuminating Mitochondrial Dynamics: Ultrahigh Labeling Stability Probe for Long-Term SIM Super-Resolution Imaging of Mitochondria35
nuPRISM: Microfluidic Genome-Wide Phenotypic Screening Platform for Cellular Nuclei35
Discovery of New States of Immunomodulation for Vaccine Adjuvants via High Throughput Screening: Expanding Innate Responses to PRRs35
O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression35
Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo35
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C–H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors34
Mucins Inhibit Coronavirus Infection in a Glycan-Dependent Manner34
Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors34
Defect Engineering of Ceria Nanocrystals for Enhanced Catalysis via a High-Entropy Oxide Strategy34
Azido Groups Hamper Glycan Acceptance by Carbohydrate Processing Enzymes34
Genetically Encoded Photocatalysis Enables Spatially Restricted Optochemical Modulation of Neurons in Live Mice34
Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies34
Brightening New Horizons: Luminescent Transition Metal Complexes in Optical Imaging and Theranostic Applications34
High-Throughput Experimentation, Theoretical Modeling, and Human Intuition: Lessons Learned in Metal–Organic-Framework-Supported Catalyst Design34
Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models34
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An Isopotential Electron Titration Device Enables Real-Time Measurement of Transient Charge Transfer on Surfaces33
Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase33
Cyclic Ruthenium-Peptide Prodrugs Penetrate the Blood–Brain Barrier and Attack Glioblastoma upon Light Activation in Orthotopic Zebrafish Tumor Models33
A Conversation with John Moon33
Overcoming O–H Insertion to Para-Selective C–H Functionalization of Free Phenols: Rh(II)/Xantphos Catalyzed Geminal Difunctionalization of Diazo Compounds33
Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses33
Interpretable Machine Learning on Metabolomics Data Reveals Biomarkers for Parkinson’s Disease33
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A Conversation with Sumit Chanda, Antiviral Drug Discovery Scientist33
Issue Editorial Masthead33
Phosphonated Ionomers of Intrinsic Microporosity with Partially Ordered Structure for High-Temperature Proton Exchange Membrane Fuel Cells33
Comprehensive Structure–Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations32
Innovative CRISPR Screening Promotes Drug Target Identification32
In Vitro Selection of Cyclized, Glycosylated Peptide Antigens That Tightly Bind HIV High Mannose Patch Antibodies32
Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin32
Deep Learning-Predicted Dihydroartemisinin Rescues Osteoporosis by Maintaining Mesenchymal Stem Cell Stemness through Activating Histone 3 Lys 9 Acetylation31
Topologically Controlled Syntheses of Unimolecular Oligo[n]catenanes31
STING-Activating Polymer–Drug Conjugates for Cancer Immunotherapy31
Postfunctionalized Covalent Organic Frameworks for Water Harvesting31
Estimation of Electrostatic Interaction Energies on a Trapped-Ion Quantum Computer30
Correction to “Mannosylated STING Agonist Drugamers for Dendritic Cell-Mediated Cancer Immunotherapy”30
An Efficient One-Step Reaction for the Preparation of Advanced Fused Bistetrazole-Based Primary Explosives30
Sticky or Not: Adhesion by Architectural Design30
Oceanographers Comb Waters for Genetic Warnings of a Coastal Neurotoxin30
Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates30
A Conversation with Ashok Kumar Singh30
Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists–Inverse Agonists with Reduced Withdrawal Effects30
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Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways30
Bayesian Optimization over Multiple Experimental Fidelities Accelerates Automated Discovery of Drug Molecules29
Revealing Anisotropic Growth of Liraglutide Oligomers by Native Ion Mobility Mass Spectrometry and Molecular Dynamics Simulation29
This Striking Blue Made Pigment History. Could Red Be Next?29
Reshaping Tumor-Lymph Node Immune Axis via Targeted Lymphatic Delivery of Dual-Functional Immune Modulator for Enhanced Cancer Immunotherapy29
Minimalist Design of an Intrinsically Disordered Protein-Mimicking Scaffold for an Artificial Membraneless Organelle28
Bottom-Up Synthesis of Multiply Fused PdII Anthriporphyrinoids28
Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue28
Facile Access to Hindered Ethers via Photoinduced O–H Bond Insertions28
Identification of a Privileged Scaffold for Inhibition of Sterol Transport Proteins through the Synthesis and Ring Distortion of Diverse, Pseudo-Natural Products28
Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning28
Pentaphosphorylation via the Anhydride of Dihydrogen Pentametaphosphate: Access to Nucleoside Hexa- and Heptaphosphates and Study of Their Interaction with Ribonuclease A27
Identifying Opportunity Targets in Gram-Negative Pathogens for Infectious Disease Mitigation27
Photoinduced Immobilization on Two-Dimensional Nano Borophene Spatially Orients Capture Antibody for Highly Sensitive Biological Interactions27
Robust Covalent Aptamer Strategy Enables Sensitive Detection and Enhanced Inhibition of SARS-CoV-2 Proteins27
Self-Standing Porous Aromatic Framework Electrodes for Efficient Electrochemical Uranium Extraction27
Carbamate Prodrugs Restrict In Vivo Metabolism and Improve the Pharmacokinetics of Isoniazid27
Revealing the Impacts of Chemical Complexity on Submicrometer Sea Spray Aerosol Morphology27
The Path to Paxlovid27
The Animation Lab Brings Molecules to Life27
The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses27
Bespoke and Accessible Electrochemical Reactors26
A Conversation with Belén González-Gaya26
Amino Acid Sequence Controls Enhanced Electron Transport in Heme-Binding Peptide Monolayers26
Data-Driven Prediction of Enantioselectivity for the Sharpless Asymmetric Dihydroxylation: Model Development and Experimental Validation26
Issue Editorial Masthead25
Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-225
Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity25
Visualizing Composition and Functionality of Porous Catalysts Using Dual-Emissive Fluorescent Nanoprobes25
Targeted NAT10 Degradation by PROTAC NP1192 Suppresses Hypoxia-Adaptive Glycolysis and Reinvigorates CD8 + Effector T-Cell Function for Synergistic C25
Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells25
Spatiotemporal Regulation of Cell Fate in Living Systems Using Photoactivatable Artificial DNA Membraneless Organelles24
An Electrolyte with Elevated Average Valence for Suppressing the Capacity Decay of Vanadium Redox Flow Batteries24
A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers24
Multivariate Hydrogen-Bonded Organic Frameworks for Optimum Atmospheric Water Harvesting24
Pinpointing the Onset of Water Harvesting in Reticular Frameworks from Structure24
Inverse Design of Pore Wall Chemistry To Control Solute Transport and Selectivity24
In Crystallo Photochemistry: Reimagining Synthetic Tractability with Transparent Single-Crystalline Flasks24
Enantioseparation in Hierarchically Porous Assemblies of Homochiral Cages24
Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts24
Modern Disposable E-Cigarettes: Small in Size but Big in Toxic Metals24
Ni- and Ni/Pd-Catalyzed Reductive Coupling of Lignin-Derived Aromatics to Access Biobased Plasticizers24
Tailoring and Identifying Brønsted Acid Sites on Metal Oxo-Clusters of Metal–Organic Frameworks for Catalytic Transformation24
Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome23
Tuning Single-Polymer Growth via Hydrogen Bonding in Conformational Entanglements23
A Hitchhiker’s Guide to Problem Selection in Carbohydrate Synthesis23
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections23
Bimolecular Homolytic Substitution (S H 2) and Radical Ligand Transfer (RLT): Emerging Paradigms in Radical Transformations23
Quantum Computing Based Design of Multivariate Porous Materials23
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics23
Real-Time Monitoring of the Level and Activity of Intracellular Glutathione in Live Cells at Atomic Resolution by 19F-NMR23
A Simple yet Efficient Hydrophilic Phenanthroline-Based Ligand for Selective Am(III) Separation under High Acidity23
Framework Membranes for Aqueous Batteries: From Microporous, Mesoporous to Macroporous Structures23
LUNAS: A Rapid and Sensitive Nucleic Acid Detection Assay Using Split NanoLuc Luciferase Complementation22
Long COVID Researchers Are on the Hunt for Causes and Cures22
Zoogeochemists Measure How Muddy Animals Change Their Environments’ Chemistry22
Structural–Energetic Basis for Coupling between Equilibrium Fluctuations and Phosphorylation in a Protein Native Ensemble22
Recruitment of Aβ into α-Synuclein Condensates Catalyzes Primary Nucleation of α-Synuclein Aggregation22
Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBRUB10712) of Streptococcus gordonii22
A Conversation with Raffaele Mezzenga22
Instant Adhesion of Amyloid-like Nanofilms with Wet Surfaces21
Global Voices, Shared Futures: Early-Career Scientists on the Power of Collaboration21
A Translation-Independent Directed Evolution Strategy to Engineer Aminoacyl-tRNA Synthetases21
Structural Reassignment of Covalent Organic Framework-Supported Palladium Species: Heterogenized Palladacycles as Efficient Catalysts for Sustainable C–H Activation21
Novel Ambient Oxidation Trends in Fingerprint Aging Discovered by Kendrick Mass Defect Analysis21
Mechanically Diverse Gels with Equal Solvent Content21
From Beam Damage to Massive Reaction Amplification under the Electron Microscope: An Ionization-Induced Chain Reaction in Crystals of a Dewar Benzene21
Issue Editorial Masthead21
How Japan Took the Lead in the Race to Discover Element 11921
Tandem Reactions over Zeolite-Based Catalysts in Syngas Conversion20
Development and Application of Cationic Nile Blue Probes in Live-Cell Super-Resolution Imaging and Specific Targeting to Mitochondria20
Nickel(II) Catalyzed Atroposelective Aerobic Oxidative Aryl–Aryl Cross-Coupling20
Host Cell Membrane Capture by the SARS-CoV-2 Spike Protein Fusion Intermediate20
A Conversation with Steve Trim20
Unexpected Damage on Metal Artifacts Triggered by the Hazardous Interfacial Interaction from Aging of Polymer Coatings20
The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella20
Retraction of “Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial”20
A Conversation with Greta Heydenrych20
A Layered Organic Cathode for High-Energy, Fast-Charging, and Long-Lasting Li-Ion Batteries20
Remote Sensing for Crops Spots Pests and Pathogens20
Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines20
Predicting the Plateau Modulus from Molecular Parameters of Conjugated Polymers20
How Do Wildfires Affect Water Systems?20
Scientists Try to Curb Livestock Emissions19
The Rise and Promise of Macrocyclic Hosts in Biomedicine19
Unlocking the Nucleophilicity of Strong Alkyl C–H Bonds via Cu/Cr Catalysis19
Local Ordering for Decoupling Bonding of Mobile Ions and Polymer Matrixes by Zwitterionic Solid Polymer Electrolytes19
Gold Nanoparticles with Adaptable Self-Assembled Monolayer Shells Allow Multivalent Inhibition and Sensing of Influenza Virus at Ultralow Concentrations19
Chemical Synthesis of Human Proteoforms and Application in Biomedicine19
Bioreversible Anionic Cloaking Enables Intracellular Protein Delivery with Ionizable Lipid Nanoparticles19
Riemannian Surface on Carbon Anodes Enables Li-Ion Storage at −35 °C19
Facile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM119
Strand-Swapped SH3 Domain Dimer with Superoxide Dismutase Activity19
Robotic Modules for the Programmable Chemputation of Molecules and Materials19
Toward Bottom-Up Understanding of Transport in Concentrated Battery Electrolytes19
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Cinematographic Recording of a Metastable Floating Island in Two- and Three-Dimensional Crystal Growth18
How the James Webb Space Telescope Is Revealing the Weather and Chemistry on Planets around Other Stars18
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Is There More to Magic Mushrooms than Psilocybin?18
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A Genetically Encoded Approach for Breaking Chromatin Symmetry18
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