OOIR: Observatory of International Research

Papers

(The median citation count of ACS Central Science is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products	510
Pyrazinone Biosynthesis and Signaling─Myxo Style	482
Alexandrian Cut in Downstream Lignin Valorization to Yield Novel Plasticizers	291
Issue Editorial Masthead	258
Tailoring and Identifying Brønsted Acid Sites on Metal Oxo-Clusters of Metal–Organic Frameworks for Catalytic Transformation	252
Bicyclic Schellman Loop Mimics (BSMs): Rigid Synthetic C-Caps for Enforcing Peptide Helicity	247
Diffusive Dynamics of Bacterial Proteome as a Proxy of Cell Death	246
A Sample-Centric and Knowledge-Driven Computational Framework for Natural Products Drug Discovery	216
Detecting the First Hydration Shell Structure around Biomolecules at Interfaces	196
Issue Publication Information	179
A Conversation with Francis Collins	148
Issue Editorial Masthead	146
Life as a Chronically Ill PhD Student	143
Is Fluorinating Polyethylene a Health Threat?	141
Rational Vaccinology: Harnessing Nanoscale Chemical Design for Cancer Immunotherapy	137
Transition State Theory-Inspired Neural Network for Estimating the Viscosity of Deep Eutectic Solvents	129
Ni- and Ni/Pd-Catalyzed Reductive Coupling of Lignin-Derived Aromatics to Access Biobased Plasticizers	127
Heterogeneous Charged Complexes of Random Copolymers for the Segregation of Organic Molecules	123
Issue Publication Information	113
Correspondence on “An International Study Evaluating Elemental Analysis”	106
A Conversation with Clare Grey	98
Issue Editorial Masthead	91
Total Synthesis of Poisonous Aconitum Alkaloids Empowered by a Fragment Coupling Strategy	91
Issue Editorial Masthead	90
Manipulating Tyrosine Phosphorylation by Heterobifunctional Small Molecules	88

High-Performance Genetically Encoded Green Fluorescent Biosensors for Intracellular l-Lactate	88
Building a Porous Molecular Machine That Replicates Natural Enzymes	88
Homogeneously Mixing Different Metal–Organic Framework Structures in Single Nanocrystals through Forming Solid Solutions	87
GEN-Click: Genetically Encodable Click Reactions for Spatially Restricted Metabolite Labeling	87
Modular Integration of Hydrogel Neural Interfaces	84
Spiro-strain Takes Chemiluminescence to Flash-Mode	82
Silanol-Assisted High-Yield Nanofabrication of SnO₂ Single Crystals with Highly Tunable and Ordered Mesoporosity	78
A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers	76
Dual-Selective Catalysis in Dephosphorylation Tuned by Hf₆-Containing Metal–Organic Frameworks Mimicking Phosphatase	76
Absolute Affinities from Quantitative Shotgun Glycomics Using Concentration-Independent (COIN) Native Mass Spectrometry	75
Issue Publication Information	74
A Conversation with Karina Sand	74
Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains	73
Phage-Assisted Continuous Evolution and Selection of Enzymes for Chemical Synthesis	72
Issue Editorial Masthead	72
Issue Editorial Masthead	69
Issue Publication Information	67
A Conversation with Maiken Ueland	65
A Conversation with Loreto Paulino Jr.	63
A Conversation with Kayla Ivey	63
Electrochemistry Cracks the P–O Bond: Sustainable Reduction of Phosphates to Phosphorus	63
High-Entropy Engineering in Hollow Layered Hydroxide Arrays to Boost 5-Hydroxymethylfurfural Electrooxidation by Suppressing Oxygen Evolution	62
A Conversation with Wil Srubar	61
Ultra-High Purity and Productivity Separation of CO₂ and C₂H₂ from CH₄ in Rigid Layered Ultramicroporous Material	59
New Rocaglate Derivatives Tip the Scale against Brain Tumors	59
Fantastic Frustrated Materials–and Where to Find Them	59
In Silico Discovery of 5′-Modified 7-Deoxy-7-ethynyl-4′-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor	57
An Ecosystem for Digital Reticular Chemistry	56
Discovering New Chemistry with an Autonomous Robotic Platform Driven by a Reactivity-Seeking Neural Network	56
Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin	54
Catching Threads in Bacterial Cell Walls	52
Identification and Detection of a Peptide Biomarker and Its Enantiomer by Nanopore	52
Issue Editorial Masthead	52
Issue Publication Information	51
A Conversation with Karin Öberg	51
Issue Publication Information	51
β-Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism	49
Teaching Chemistry Labs from a Distance	49
The Animation Lab Brings Molecules to Life	49
Biomolecular Chirality Is Imprinted on One Layer of Hydration Water	49
Caught in the Act of Substitution: Interadsorbate Effects on an Atomically Precise Fe/Co/Se Nanocluster	49
Making Natural Products Supernatural	49
Issue Publication Information	48
Electrochemical Cation-Swing for Carbon Capture under Ambient Conditions	48
Proteomics Offers New Clues for Forensic Investigations	47
Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform	47
Tuning Single-Polymer Growth via Hydrogen Bonding in Conformational Entanglements	46
Offsetting Low-Affinity Carbohydrate Binding with Covalency to Engage Sugar-Specific Proteins for Tumor-Immune Proximity Induction	45
Halide Perovskites Breathe Too: The Iodide–Iodine Equilibrium and Self-Doping in Cs₂SnI₆	44
Nature Chose Phosphates and Chemists Should Too: How Emerging P(V) Methods Can Augment Existing Strategies	44

Radiochemistry: A Hot Field with Opportunities for Cool Chemistry	44
HOPS-Dependent Endosomal Escape Demands Protein Unfolding	44
Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity	44
Issue Publication Information	43
Protein Structure-Based Organic Chemistry-Driven Ligand Design from Ultralarge Chemical Spaces	43
CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2	43
A Regiospecific Co-Assembly Method to Functionalize Ordered Mesoporous Metal Oxides with Customizable Noble Metal Nanocrystals	43
High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register	42
Stationary DNA Origami Register Drives Fast Sequential DNA Computing	42
The Utility of Cyclodextrin for Countering μ-Opioid Receptor Drug Overdoses	42
Teaching an Old Dog New Tricks for Achieving CB₂-Selective Inverse Agonism	41
PEARL-Catalyzed Peptide Bond Formation after Chain Reversal by Ureido-Forming Condensation Domains	41
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics	41
Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase	40
Carbon-Centered Radicals in Protein Manipulation	39
Edible Matrix Code with Photogenic Silk Proteins	39
Probing Kinetics of Water-in-Salt Aqueous Batteries with Thick Porous Electrodes	39
Trace Hydrogen Sulfide Sensing Inspired by Polyoxometalate-Mediated Aerobic Oxidation	38
Dual Salt Cation-Swing Process for Electrochemical CO₂ Separation	38
Mechanical Bond Approach to Introducing Self-Adaptive Active Sites in Covalent Organic Frameworks for Zinc-Catalyzed Organophosphorus Degradation	37
Mapping Protein–Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome–Nascent Globin Complex	37
Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome	37
Intracellular Relaxometry, Challenges, and Future Directions	37
Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations	36
A New Facility Will Harness Plasma to Guide Interplanetary Craft	36
Molecular Prosthetics for Long-Term Functional Imaging with Fluorescent Reporters	36
Interrogating RNA–Small Molecule Interactions with Structure Probing and Artificial Intelligence-Augmented Molecular Simulations	36
Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months	36
Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells	36
Spatiotemporal Regulation of Cell Fate in Living Systems Using Photoactivatable Artificial DNA Membraneless Organelles	35
An Electrolyte with Elevated Average Valence for Suppressing the Capacity Decay of Vanadium Redox Flow Batteries	34
Inhibiting Dendrite Growth via Regulating the Electrified Interface for Fast-Charging Lithium Metal Anode	34
Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics	34
Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents	34
Real-Time Fast Amyloid Seeding and Translocation of α-Synuclein with a Nanopipette	34
A Simple yet Efficient Hydrophilic Phenanthroline-Based Ligand for Selective Am(III) Separation under High Acidity	34
Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2	34
Exploring Structure–Activity Relationships and Modes of Action of Laterocidine	33
Promoting CO₂ Electroreduction to Acetate by an Amine-Terminal, Dendrimer-Functionalized Cu Catalyst	33
Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase	32
Dataset Design for Building Models of Chemical Reactivity	32
“For Its Size, the Most Complex Natural Product Known.” Who Deserves Credit for Determining the Structure of Strychnine?	32
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction	31
Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders	31
Enantioseparation in Hierarchically Porous Assemblies of Homochiral Cages	31
Probing the Origin of Affinity in the GM1-Cholera Toxin Complex through Site-Selective Editing with Fluorine	31
MOF Linker Extension Strategy for Enhanced Atmospheric Water Harvesting	31
Solvent Gaming Chemistry to Control the Quality of Halide Perovskite Thin Films for Photovoltaics	30
General Synthesis of Large Inorganic Nanosheets via 2D Confined Assembly of Nanoparticles	30
Janus Emulsion Biosensors for Anti-SARS-CoV-2 Spike Antibody	30
Dynamic Activation of C1 Molecules Evoked by Zeolite Catalysis	30
Closed-Loop Electrolyte Design for Lithium-Mediated Ammonia Synthesis	30
Inverse Design of Pore Wall Chemistry To Control Solute Transport and Selectivity	30
C–H Activation: Toward Sustainability and Applications	30
Multielectrode Spectroscopy Enables Rapid and Sensitive Molecular Profiling of Extracellular Vesicles	30
Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network	29
Real-Time Monitoring of the Level and Activity of Intracellular Glutathione in Live Cells at Atomic Resolution by ¹⁹F-NMR	29
Continuum Crystallization Model Derived from Pharmaceutical Crystallization Mechanisms	29
Chemical Sensors and Imaging: Molecular, Materials, and Biological Platforms	29
Asymmetric Non-Fullerene Small-Molecule Acceptors toward High-Performance Organic Solar Cells	29
Polyethylenimine–Poly(lactic-co-glycolic acid)₂ Nanoparticles Show an Innate Targeting Ability to the Submandibular Salivary Gland via the Muscarinic 3 Receptor	29
Helical Polymer Working as a Chirality Amplifier to Generate and Modulate Multicolor Circularly Polarized Luminescence in Small Molecular Fluorophore/Polymer Composite Films	29
Controlled Preparation of Single-Walled Carbon Nanotubes as Materials for Electronics	29
GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses	28
Natural-Product-Directed Catalytic Stereoselective Synthesis of Functionalized Fused Borane Cluster–Oxazoles for the Discovery of Bactericidal Agents	28
Commemorating The Nobel Prize in Chemistry 2023 for the Discovery and Synthesis of Quantum Dots	28
Controllable Phycobilin Modification: An Alternative Photoacclimation Response in Cryptophyte Algae	28
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules	27
Phosphorus-Based Catalysis	27
The Tautomeric State of N⁴-Hydroxycytidine within Base-Paired RNA	27
Sulfonylation of RNA 2′-OH groups	26
Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability	26
Cascade Strand Displacement and Bipedal Walking Based DNA Logic System for miRNA Diagnostics	26
The Evolution of Data-Driven Modeling in Organic Chemistry	26
Hydrazine-Hydrazide-Linked Covalent Organic Frameworks for Water Harvesting	25
Discovering Relationships between OSDAs and Zeolites through Data Mining and Generative Neural Networks	25
A Hitchhiker’s Guide to Problem Selection in Carbohydrate Synthesis	25
Atomically Precise Enantiopure Bimetallic Janus Clusters	25
Creation of Cationic Polymeric Nanotrap Featuring High Anion Density and Exceptional Alkaline Stability for Highly Efficient Pertechnetate Removal from Nuclear Waste Streams	24
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections	24

Task-Driven Tailored Covalent Organic Framework for Dynamic Capture of Trace Radioactive CH₃¹³¹I under High-Flow Rate Conditions	24
Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment	24
ERCAD: A Parametric Reactor Design Tool That Enables Rapid Prototyping and Optimization of Electrochemical Reactors through 3D Printing	24
Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides	24
Correction to “O-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression”	24
Zooming in on the Glycome: Visualizing Glycans at the Nanoscale Level through Expansion Microscopy	23
A Conversation with Leo Gross	23
Disintegrate (DIN) Theory Enabling Precision Engineering of Proteins	23
Recycling of Post-Consumer Waste Polystyrene Using Commercial Plastic Additives	23
Long COVID Researchers Are on the Hunt for Causes and Cures	23
From Functional Fatty Acids to Potent and Selective Natural-Product-Inspired Mimetics via Conformational Profiling	23
Bespoke and Accessible Electrochemical Reactors	23
Searching for the Truth: Elemental Analysis–A Powerful but Often Poorly Executed Technique	23
I-SMEL a Big Catch!	23
Electronic Excited States from Physically Constrained Machine Learning	23
High-Throughput Evaluation of Emission and Structure in Reduced-Dimensional Perovskites	22
Issue Editorial Masthead	22
Gigavalent Display of Proteins on Monodisperse Polyacrylamide Hydrogels as a Versatile Modular Platform for Functional Assays and Protein Engineering	22
Issue Editorial Masthead	22
Automating Glycan Assembly in Solution	22
Issue Publication Information	22
A Conversation with Carolyn Pearce	22
Issue Editorial Masthead	22
Zoogeochemists Measure How Muddy Animals Change Their Environments’ Chemistry	22
Chemoadaptive Polymeric Assemblies by Integrated Chemical Feedback in Self-Assembled Synthetic Protocells	22
A Conversation with Fay Probert	22
Issue Publication Information	21
3D Printers Enter the Kitchen	21
Exploring Uncharted Territory: Toward Metabolite Network Maps	21
Issue Publication Information	21
Issue Publication Information	21
A Conversation with Noah Whiteman	21
Issue Publication Information	21
Correction to “A Conversation with Liangbing Hu”	21
LUNAS: A Rapid and Sensitive Nucleic Acid Detection Assay Using Split NanoLuc Luciferase Complementation	20
Thermally Activated Delayed Fluorescence Coinage Metal Cluster Scintillator	20
Synthesis and Single Crystal X-ray Diffraction Structure of an Indium Arsenide Nanocluster	20
Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine	20
Issue Publication Information	20
Chemically Tuning the Antigen Release Kinetics from Spherical Nucleic Acids Maximizes Immune Stimulation	20
Issue Editorial Masthead	20
Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins	20
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality	20
A Conversation with Sébastien Vidal	20
Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines	20
Nickel(II) Catalyzed Atroposelective Aerobic Oxidative Aryl–Aryl Cross-Coupling	20
Accelerated and Scalable C(sp³)–H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs	20
Activity-Based NIR Bioluminescence Probe Enables Discovery of Diet-Induced Modulation of the Tumor Microenvironment via Nitric Oxide	20
Surface Curvature Matters in Electrochemical Reactions	20
Engineering the ChlorON Series: Turn-On Fluorescent Protein Sensors for Imaging Labile Chloride in Living Cells	19
Science That Looks Like Me, That Looks Like Us	19
An International Study Evaluating Elemental Analysis	19
Issue Editorial Masthead	19
Packing Metal–Organic Frameworks into an Opal Structure	19
Cationic Catalysts as a New Strategy to Catalyze N-Carboxyanhydrides Polymerization	19
Nanopore Dwell Time Analysis Permits Sequencing and Conformational Assignment of Pseudouridine in SARS-CoV-2	19
Issue Editorial Masthead	19
Issue Editorial Masthead	18
All-Atom Mesoscale Simulations Predict the Conformational Dynamics of Influenza Virus Surface Glycoproteins	18
Picture Perfect Precision: Biorthogonal Photoactivatable Tools Achieve Imaging with Molecular-Scale Precision	18
A Conversation with Julie Dunne	18
Unlocking Efficient O₂ Electroreduction in Conductive MOFs via Enhanced Mass Transport	18
A Chemical Tool for Guiding Li Therapy	18
A Conversation with Najat Saliba	18
Issue Publication Information	18
Correction to “New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance”	18
Driving a Multistep Electron Transport Chain between Macrocycles with Chemically Mediated Proton-Coupled Electron Transport	18
Issue Publication Information	18
Issue Publication Information	18
Issue Publication Information	18
Proximitomics by Reactive Species	18
Bistable Photoswitch Allows in Vivo Control of Hematopoiesis	18
Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals	17
Controlled Polymerization of Norbornene Cycloparaphenylenes Expands Carbon Nanomaterials Design Space	17
Tetranucleosome Interactions Drive Chromatin Folding	17
Development and Application of Cationic Nile Blue Probes in Live-Cell Super-Resolution Imaging and Specific Targeting to Mitochondria	17
Remote Sensing for Crops Spots Pests and Pathogens	17
A Greener Vision for P–C Bond Formation	17
Base-Resolution Analysis of Deoxyuridine at the Genome Scale Based on the Artificial Incorporation Modified Nucleobase	17
A Translation-Independent Directed Evolution Strategy to Engineer Aminoacyl-tRNA Synthetases	17
Quantifying Biomolecular Interactions Using Slow Mixing Mode (SLOMO) Nanoflow ESI-MS	17
An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity	17
Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions	17
Bioorthogonal Chemical Ligation Creates Synthetic Antibodies with Improved Therapeutic Potency	17
Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice	16
A Pair of Fluorescent Probes Enabling Precise Diagnosis of Liver Cancer by Complementary Imaging	16
Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome	16
Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism	16
Biomimetic Nacrelike Membranes for Selective Ion Transport	16
Large-Scale Production of Hierarchically Porous Metal–Organic Frameworks by a Reflux-Assisted Post-Synthetic Ligand Substitution Strategy	16
Engineered Bioluminescent Indicator Enables the Brain Imaging of Kinase Inhibitors	16
Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking	16
Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress	16
The Precise Engineering of Nanostructured Carbon Materials	16
Issue Editorial Masthead	16