OOIR: Observatory of International Research

Papers

(The TQCC of npj Microgravity is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station	94
Implications of sex differences in orthostatic tolerance during exposure to acute artificial gravity	88
Corner angle effects on capillary rise along curved interior corners	84
Vection underwater illustrates the limitations of neutral buoyancy as a microgravity analog	66
Optic nerve sheath diameter and spaceflight: defining shortcomings and future directions	64
Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length	64
A study on the stability of ritonavir form III processed in orbit and returned to Earth	55
Neurological complications in microgravity and long duration spaceflight	51
MicroAge mission: experimental design and hardware for a bespoke culture system supporting tissue-engineered skeletal muscle	45
The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps	44
Cooling of a granular gas mixture in microgravity	42
Microgravity triggers ferroptosis and accelerates senescence in the MG-63 cell model of osteoblastic cells	42
Effect of microgravity on mechanical loadings in lumbar spine at various postures: a numerical study	40
Spaceflight exposome/microgravity effects on the psychoimmunoneuroendocrine system	39
Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity	37
Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity	36
Long-term microgravity experiments reveal a new mechanism for particle aggregation in suspension	33
Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest	32
Demonstration of charge-hold-vent (CHV) and no-vent-fill (NVF) in a simulated propellent storage tank during tank-to-tank cryogen transfer in microgravity	32
Microgravity-induced constraints on melanin bioproduction: investigating E. coli metabolic responses aboard the international space station	32
Management of corneal injuries in spaceflight and recommendations for planetary missions	31
Abdominal LIPUS ameliorates simulated microgravity induced skeletal muscle atrophy via the gut-muscle axis	30
Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station	30
Weightlessness leads to an increase granulosa cells in the growing follicle	29
Virtual reality-based sensory stimulation preferences at Amundsen-Scott South Pole station in Antarctica	29

Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases	29
Illumination optimization and low-power trapping of Limnospira indica PCC 8005 using bulk acoustic waves in microgravity	28
Cardiovascular and central nervous system risk in astronauts: the minipig as a physiologically relevant radiation model	28
Passive limitation of surface contamination by perFluoroDecylTrichloroSilane coatings in the ISS during the MATISS experiments	28
In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression	28
PI3K/AKT/mTOR pathway and c-Myc inhibit hepatocyte suspension under simulated microgravity	27
Brief Communication: Confocal microscopy of oral streptococcal biofilms grown in simulated microgravity using a random positioning machine	27
Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review	25
Publisher Correction: Active matter in space	24
Substrate metabolism in male astronauts onboard the International Space Station: the ENERGY study	24
Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts	24
Comparison of musculoskeletal responses and its variability after long-term spaceflight and prolonged bed rest conditions	24
Space habitats for bioengineering and surgical repair: addressing the requirement for reconstructive and research tissues during deep-space missions	24
Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in mice	23
Comparison of clinostat control strategies to achieve simulated microgravity with uniform gravity vector distribution	23
NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions	23
Optical observations of thunderstorms from the International Space Station: recent results and perspectives	22
Potential regulatory modules to integrate microgravity signals into flowering pathways in Arabidopsis thaliana grown in space	22
Cryogenic helium subsurface pressurization in terrestrial and low-gravity: experiments and flow visualization	22
Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog	22
Simulated microgravity impairs human NK cell cytotoxic activity against space radiation-relevant leukemic cells	21
Label-free blood cell separation for space health monitoring using a portable blast cell biochip	21
RNA-seq analysis in simulated microgravity unveils down-regulation of the beta-rhizobial siderophore phymabactin	21
Synthetic biology for space exploration	20
Free surface bubbly flow in an open capillary channel	20
Recovery of bone microarchitecture and density four years after spaceflight: two case studies	20
Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest	20
External to internal cranial perfusion shifts during simulated weightlessness: Results from a randomized cross-over trial	20
A moonshot for female astronaut health, a win for all astronauts and space exploration	19
The value of a spaceflight clinical decision support system for earth-independent medical operations	19
Stem cells in space: microgravity effects on stem cell fate and implications for regenerative medicine	19
Simulated lunar microgravity transiently arrests growth and induces osteocyte-chondrocyte lineage differentiation in human Wharton’s jelly stem cells	19
Infectious disease outcomes of NASA’s health stabilization program	19
Longitudinal alterations in lower extremity quantitative MRI metrics under simulated microgravity and their associations with systemic biomarkers	19
Effectiveness of caffeine and blue-enriched light on cognitive performance and electroencephalography correlates of alertness in a spaceflight robotics simulation	18
Simulated microgravity-driven mechanical unloading rescues PIEZO1-overexpression-induced growth plate ossification and retards adolescent idiopathic scoliosis	18
Modelling large scale artery haemodynamics from the heart to the eye in response to simulated microgravity	18
Uncertainty analysis and performance evaluation of thermophysical property measurement of liquid Au in microgravity	18
Effects of caffeine and blue-enriched light on spare visual attention during simulated space teleoperation	17
Plasma nitrogen fixation for future lunar agriculture	17
A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: lessons from human and animal studies	17
A biological and ethical assessment of whether humans could or should reproduce in space	17
GLARE: discovering hidden patterns in spaceflight transcriptome using representation learning	17
Endothelial dysfunction markers and immune response indices in cosmonauts’ blood after long-duration space flights	17
Examining the influence of turbulence on viscosity measurements of molten germanium under reduced gravity	16
Unlocking the potential: analyzing 3D microstructure of small-scale cement samples from space using deep learning	16
Survival strategies of Rhinocladiella similis in perchlorate-rich Mars like environments	16
Changes in real-world walking speed following 60-day bed-rest	16
Validated space radiation exposure predictions from earth to mars during Artemis-I	15
Mechanism of LEPR-mediated cholesterol metabolism involved in NK cell function suppression under simulated microgravity	15

Modeling the risk of airborne transmission of respiratory viruses in microgravity	15
Early skeletal deteriorations following short-duration spaceflight	15
The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue	15
Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice	15
Rare diseases and space health: optimizing synergies from scientific questions to care	15
Extreme environment provides clues about socio-environmental stressors contribution to ISS-induced changes in antibody repertoire	15
Hypergravity is more challenging than microgravity for the human sensorimotor system	15
Long-term molecular effects of 16O-ion exposure in rat brain and implications for space radiation risk	14
Inspiration4 data access through the NASA Open Science Data Repository	14
Formaldehyde initiates memory and motor impairments under weightlessness condition	14
Space-driven ROS in cells: a hidden danger to astronaut health and food safety	14
Microgravity studies of solidification patterns in model transparent alloys onboard the International Space Station	14
Future space experiment platforms for astrobiology and astrochemistry research	14
Response of cardiac pulse parameters in humans at various inclinations via 360° rotating platform for simulated microgravity perspective	14
Resilience of otolithic reflex to gravitational changes	13
Scientific perspectives on lunar exploration in Europe	13
Fluidic shaping and in-situ measurement of liquid lenses in microgravity	13
Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review	13
Unraveling dispersion and buoyancy dynamics around radial A + B → C reaction fronts: microgravity experiments and numerical simulations	13
The effect of space travel on human reproductive health: a systematic review	13
The impact of gravity on perceived object height	13
Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles	13
Development and flight-testing of modular autonomous cultivation systems for biological plastics upcycling aboard the ISS	13
Reinforcement learned adversarial agent (ReLAA) for active fault detection and prediction in space habitats	13
Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome	12
Efficient long-term cryopreservation of Arthrospira platensis NIES-39 and adaptation for the Space Algae-2 spaceflight experiment	12
Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth	12
Influence of the spaceflight environment on macrophage lineages	12
Assessing the scientific and economic impacts of the experiments conducted onboard the International Space Station	12
Critical investments in bioregenerative life support systems for bioastronautics and sustainable lunar exploration	11
Electromagnetic levitation containerless processing of metallic materials in microgravity: rapid solidification	11
Microbial applications for sustainable space exploration beyond low Earth orbit	11
NemaCapsules: microfluidics-integrated biocells for investigating C. elegans host-microbiome interactions in spaceflight	11
A demographic comparison of NASA astronauts and commercial spaceflight participants	11
Nitrogen flow boiling and chilldown experiments in microgravity using pulse flow and low-thermally conductive coatings	11
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight	11
RIIST, resonance induced instability for surface tension measurement, a new technique with experiments in microgravity	11
Magnetic phase separation in microgravity	11
Soil conditioning for enhancing plant growth using biochar and hydrochar under microgravity	11
The effect of long-term spaceflight on drug potency and the risk of medication failure	11
Submarine medicine as an analog for spaceflight: a review of acute medical care	11