OOIR: Observatory of International Research

Papers

(The median citation count of npj Microgravity is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars	151
A systematic review and meta-analysis of bone loss in space travelers	99
How does spaceflight affect the acquired immune system?	61
Update on the effects of microgravity on the musculoskeletal system	56
A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration	54
High intensity training during spaceflight: results from the NASA Sprint Study	48
Cardiovascular deconditioning during long-term spaceflight through multiscale modeling	45
Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome	43
Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions	38
The effects of microgravity on bone structure and function	36
The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis	35
Gravity sensing in plant and animal cells	32
Trabecular bone organoids: a micron-scale ‘humanised’ prototype designed to study the effects of microgravity and degeneration	30
COVID-19—The largest isolation study in history: the value of shared learnings from spaceflight analogs	30
Macrophages in microgravity: the impact of space on immune cells	29
Estimating medical risk in human spaceflight	27
The effects of real and simulated microgravity on cellular mitochondrial function	26
Feasibility, potency, and safety of growing human mesenchymal stem cells in space for clinical application	25
Planetary extravehicular activity (EVA) risk mitigation strategies for long-duration space missions	21
Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression	20
Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity	20
Critical heat flux enhancement in microgravity conditions coupling microstructured surfaces and electrostatic field	19
Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity	19
Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest	18
Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment	17

Sessile volatile drop evaporation under microgravity	17
Quantitative magnetic resonance image assessment of the optic nerve and surrounding sheath after spaceflight	16
Capillary flow of liquids in open microchannels: overview and recent advances	16
3D cell culture using a clinostat reproduces microgravity-induced skin changes	14
Overview of lunar dust toxicity risk	14
Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity	14
Impact of convection on the damping of an oscillating droplet during viscosity measurement using the ISS-EML facility	14
Modeled microgravity alters lipopolysaccharide and outer membrane vesicle production of the beneficial symbiont Vibrio fischeri	14
Nanopore sequencing at Mars, Europa, and microgravity conditions	14
An advance in transfer line chilldown heat transfer of cryogenic propellants in microgravity using microfilm coating for enabling deep space exploration	13
Opposite response of blood vessels in the retina to 6° head-down tilt and long-duration microgravity	12
Towards sustainable human space exploration—priorities for radiation research to quantify and mitigate radiation risks	12
Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth	12
Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts	12
Additive effects of simulated microgravity and ionizing radiation in cell death, induction of ROS and expression of RAC2 in human bronchial epithelial cells	12
Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome	11
Demonstration of the effect of stirring on nucleation from experiments on the International Space Station using the ISS-EML facility	11
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats	11
The ejection of large non-oscillating droplets from a hydrophobic wedge in microgravity	11
A way forward for fundamental physics in space	10
Characterization of amyloid β fibril formation under microgravity conditions	10
Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice	10
Nitrogen flow boiling and chilldown experiments in microgravity using pulse flow and low-thermally conductive coatings	10
Six degrees head-down tilt bed rest caused low-grade hemolysis: a prospective randomized clinical trial	10
Is contact-line mobility a material parameter?	10
Bone health in spacefaring rodents and primates: systematic review and meta-analysis	9
Impairment of 7F2 osteoblast function by simulated partial gravity in a Random Positioning Machine	9
How advances in low-g plumbing enable space exploration	9
Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium	9
Mechanical loading recovers bone but not muscle lost during unloading	9
Mechanism for enhancing the growth of mung bean seedlings under simulated microgravity	9
Robot-assisted surgery in space: pros and cons. A review from the surgeon’s point of view	9
Mechanical deconditioning of the heart due to long-term bed rest as observed on seismocardiogram morphology	8
Detailed modelling of contact line motion in oscillatory wetting	8
Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice	8
Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites	8
Oscillations of a soft viscoelastic drop	7
Improved feasibility of astronaut short-radius artificial gravity through a 50-day incremental, personalized, vestibular acclimation protocol	7
Ocular conditions and injuries, detection and management in spaceflight	7
Diffusion in liquid mixtures	7
Single-bubble EHD behavior into water two-phase flow under electric-field stress and gravitational acceleration using PFM	7
Microbial applications for sustainable space exploration beyond low Earth orbit	7
Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans	7
Human behavior and performance in deep space exploration: next challenges and research gaps	7
Brain stimulation in zero gravity: transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flight	7
The draining of capillary liquids from containers with interior corners aboard the ISS	7
Equivalence of sessile droplet dynamics under periodic and steady electric fields	7
Enhanced self-renewal of human pluripotent stem cells by simulated microgravity	6
Zero gravity induced by parabolic flight enhances automatic capture and weakens voluntary maintenance of visuospatial attention	6
Author Correction: Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update	6

Scientific perspectives on lunar exploration in Europe	6
Molecular impact of launch related dynamic vibrations and static hypergravity in planarians	6
Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts	6
Future space experiment platforms for astrobiology and astrochemistry research	6
Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station	5
Sessile drops in weightlessness: an ideal playground for challenging Young’s equation	5
Ocular counter-roll is less affected in experienced versus novice space crew after long-duration spaceflight	5
Benchmarking surface tension measurement method using two oscillation modes in levitated liquid metals	5
Magnetic phase separation in microgravity	5
Complex plasma research under microgravity conditions	5
Calycosin prevents bone loss induced by hindlimb unloading	5
Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction	5
Evaluating the lettuce metatranscriptome with MinION sequencing for future spaceflight food production applications	5
Electrolysis in reduced gravitational environments: current research perspectives and future applications	5
Altered sleep spindles and slow waves during space shuttle missions	5
1D and 3D co-simulation and self-adaptive position control of electrostatic levitation in China’s Space Station	5
A three-dimensional flow model of screen channel liquid acquisition devices for propellant management in microgravity	5
Automatic extraction channel of space debris based on wide-field surveillance system	5
Transcriptomic response of bioengineered human cartilage to parabolic flight microgravity is sex-dependent	5
Next-generation sequencing analysis of circulating micro-RNA expression in response to parabolic flight as a spaceflight analogue	5
Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis	5
A perspective on spaceflight associated neuro-ocular syndrome causation secondary to elevated venous sinus pressure	5
Testing 3D printed biological platform for advancing simulated microgravity and space mechanobiology research	5
Fundamentals and future applications of electrochemical energy conversion in space	5
Dynamics of entomopathogenic nematode foraging and infectivity in microgravity	5
Scaffold-based bone tissue engineering in microgravity: potential, concerns and implications	5
The effect of long-term spaceflight on drug potency and the risk of medication failure	5
Condensation heat transfer in microgravity conditions	4
Microfluidics-integrated spaceflight hardware for measuring muscle strength of Caenorhabditis elegans on the International Space Station	4
Uncertainty analysis and performance evaluation of thermophysical property measurement of liquid Au in microgravity	4
Atherogenic potential of microgravity hemodynamics in the carotid bifurcation: a numerical investigation	4
Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation	4
Granular piston-probing in microgravity: powder compression, from densification to jamming	4
Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells	4
Electromagnetic levitation containerless processing of metallic materials in microgravity: rapid solidification	4
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight	4
Plant and microbial science and technology as cornerstones to Bioregenerative Life Support Systems in space	4
Optic nerve sheath diameter and spaceflight: defining shortcomings and future directions	4
Validating ground-based aerodynamic levitation surface tension measurements through a study on Al2O3	4
Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission	4
Clustering of charged colloidal particles in the microgravity environment of space	4
The combined effects of simulated microgravity and X-ray radiation on MC3T3-E1 cells and rat femurs	4
Toward the utilisation of resources in space: knowledge gaps, open questions, and priorities	4
Revisiting the NASA surface tension driven convection experiments	4
Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now?	4
Protein structural changes on a CubeSat under rocket acceleration profile	4
Computational modeling of orthostatic intolerance for travel to Mars	4
Mental imagery of object motion in weightlessness	4
Tracing transport of protein aggregates in microgravity versus unit gravity crystallization	4
Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent	4
Active matter in space	4
4 Day in dry immersion reproduces partially the aging effect on the arteries as observed during 6 month spaceflight or confinement	4
Perfect Crystals: microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography	3
Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases	3
Numerical characterization of astronaut CaOx renal stone incidence rates to quantify in-flight and post-flight relative risk	3
The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps	3
Enhancing the precision limits of interferometric satellite geodesy missions	3
Revisiting decompression sickness risk and mobility in the context of the SmartSuit, a hybrid planetary spacesuit	3
Granular cooling of ellipsoidal particles in microgravity	3
Electromagnetic levitation containerless processing of metallic materials in microgravity: thermophysical properties	3
Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells	3
Musculoskeletal research in human space flight – unmet needs for the success of crewed deep space exploration	3
Exosome based analysis for Space Associated Neuro-Ocular Syndrome and health risks in space exploration	3
Towards a passive limitation of particle surface contamination in the Columbus module (ISS) during the MATISS experiment of the Proxima Mission	3
Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces	3
On the growth dynamics of the cyanobacterium Anabaena sp. PCC 7938 in Martian regolith	3
Inhibiting myostatin signaling partially mitigates structural and functional adaptations to hindlimb suspension in mice	3
A magnetic levitation based low-gravity simulator with an unprecedented large functional volume	3
Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity	3
Modeling a potential SANS countermeasure by experimental manipulation of the translaminar pressure difference in mice	3
Towards an extension of equivalent system mass for human exploration missions on Mars	3
The glymphatic pathway in the optic nerve: did astronauts already reveal signs of its existence?	3
Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity	3
Drop tower tests of Taiji-1 inertial sensor substitute	3
Growth of microorganisms in an interfacially driven space bioreactor analog	3