npj Parkinsons Disease

Article	Citations
Effects of Alzheimer’s genetic risk scores and CSF biomarkers in de novo Parkinson’s Disease	165
Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism	108
Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson’s disease	102
Author Correction: Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology	101
Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease	90
Patient-centered development of clinical outcome assessments in early Parkinson disease: key priorities and advances	88
Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI	86
VisionMD: an open-source tool for video-based analysis of motor function in movement disorders	84
Differences in brain aging between sexes in Parkinson’s disease	82
Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease	82
Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions	80
Reference SVA insertion polymorphisms are associated with Parkinson’s Disease progression and differential gene expression	80
Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease	80
CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in Parkinson’s disease	75
Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease	73
Advanced brain aging in Parkinson’s disease with cognitive impairment	70
Redefining the hypotheses driving Parkinson’s diseases research	69
Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD	66
A systematic exploration of unexploited genes for oxidative stress in Parkinson’s disease	66
Machine Learning in the Parkinson’s disease smartwatch (PADS) dataset	63
A versatile computational algorithm for time-series data analysis and machine-learning models	62
Unveiling early signs of Parkinson’s disease via a longitudinal analysis of celebrity speech recordings	56
α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular–mitral synaptic transmission	55
Balance response to levodopa predicts balance improvement after bilateral subthalamic nucleus deep brain stimulation in Parkinson’s disease	55
Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies	54

The experience of Anxiety for people with Parkinson’s disease	53
Immunological shifts during early-stage Parkinson’s disease identified with DNA methylation data on longitudinally collected blood samples	52
Park7 deletion leads to sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes	52
A systematic review and meta-analysis of the prevalence of Parkinson’s disease in lower to upper-middle-income countries	50
Plasma GFAP as a prognostic biomarker of motor subtype in early Parkinson’s disease	50
Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis	50
Identification of PLOD3 and LRRN3 as potential biomarkers for Parkinson’s disease based on integrative analysis	49
C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain	49
Parkinson’s disease clinical milestones and mortality	48
Mechanisms of peripheral levodopa resistance in Parkinson’s disease	47
A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease	45
Synuclein phosphorylation: pathogenic or physiologic?	45
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies	45
Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation	44
Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease	44
Impaired migratory phenotype of CD4+ T cells in Parkinson’s disease	44
Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality	43
Reply to Matters Arising: Is congenital anosmia protective for Parkinson’s disease triggered by pathogenic entrance through the nose?	42
Does Black vs. White race affect practitioners’ appraisal of Parkinson’s disease?	42
Identification of cerebrospinal fluid biomarkers for parkinsonism using a proteomics approach	42
In memorium, Michael Zigmond, PhD	41
Altered perivascular spaces in subcortical white matter in Parkinson’s disease patients with levodopa-induced dyskinesia	40
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway	39
Genetic meta-analysis of levodopa induced dyskinesia in Parkinson’s disease	39
Head-to-head comparison of four cerebrospinal fluid and three plasma neurofilament light chain assays in Parkinsonism	39
Characterization of the pathogenic α-Synuclein Variant V15A in Parkinson´s disease	38
Safinamide in the treatment pathway of Parkinson’s Disease: a European Delphi Consensus	38
MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients	37
Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder	37
A 6-month longitudinal study on worsening of Parkinson’s disease during the COVID-19 pandemic	37
Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease	37
Analysis of striatal connectivity corresponding to striosomes and matrix in de novo Parkinson’s disease and isolated REM behavior disorder	37
High neutrophil-to-lymphocyte ratio predicts short survival in multiple system atrophy	37
Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy	36
Clinical symptoms and neuroanatomical substrates of daytime sleepiness in Parkinson’s disease	36
Plasma GFAP and NfL associate with cerebral glucose metabolism in putative brain-first and body-first Parkinson’s disease subtypes	36
Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s disease	36
Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease	35
Hyposmia in Parkinson’s disease; exploring selective odour loss	35
A framework for translational therapy development in deep brain stimulation	35
Fine mapping of the HLA locus in Parkinson’s disease in Europeans	34
Oral health implications in Parkinson’s disease	34
Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints	33
Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study over 12 months	33
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids	32
Possible role of lncRNAs in amelioration of Parkinson’s disease symptoms by transplantation of dopaminergic cells	32
Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases	32
Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease	32
Predictors of stress resilience in Parkinson’s disease and associations with symptom progression	32
Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers	32

Arm swing responsiveness to dopaminergic medication in Parkinson’s disease depends on task complexity	31
Matters arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease	31
TOMM40 ‘523’ poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson’s disease	31
STN-DBS does not increase the risk of sialorrhea in patients with advanced Parkinson’s disease	31
Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors	30
Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study	30
Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease	30
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease	30
AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies	30
Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease	29
Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory	29
Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons	29
Sleep disorders in Parkinson’s disease, an early and multiple problem	29
Antagonistic network signature of motor function in Parkinson’s disease revealed by connectome-based predictive modeling	28
Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease	28
Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s disease	28
Exploring human-genome gut-microbiome interaction in Parkinson’s disease	28
Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease	28
Exploring the link between essential tremor and Parkinson’s disease	28
Impulsive-compulsive behaviour in early Parkinson’s disease is determined by apathy and dopamine receptor D3 polymorphism	27
Neurofilament light chain and α-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes	27
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease	26
Time to workforce exit after a Parkinson’s disease diagnosis	26
To restrict or not to restrict? Practical considerations for optimizing dietary protein interactions on levodopa absorption in Parkinson’s disease	26
Misfolded protein deposits in Parkinson’s disease and Parkinson’s disease-related cognitive impairment, a [11C]PBB3 study	25
Diagnostic utility of 7T neuromelanin imaging of the substantia nigra in Parkinson’s disease	25
Sentence completion in progressive supranuclear palsy following transcranial direct current stimulation	25
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)	25
Modified version of unified multiple system atrophy rating scale for remote video-based assessments	25
The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson’s disease	24
The emerging postural instability phenotype in idiopathic Parkinson disease	24
Genetically-informed prediction of short-term Parkinson’s disease progression	24
Synaptic vesicle characterization of iPSC-derived dopaminergic neurons provides insight into distinct secretory vesicle pools	24
Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease	24
Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America	24
Neuropathology of Parkinson’s disease after focused ultrasound thalamotomy	24
Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders	23
α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies	23
Structural underpinnings and long-term effects of resilience in Parkinson’s disease	23
Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages	23
Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease	22
Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins	22
Clinical subtypes in patients with isolated REM sleep behaviour disorder	22
Spatial variations and precise location of substantia nigra hyperechogenicity in Parkinson’s disease using TCS-MR fusion imaging	22
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies	22
A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease	22
Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment	22
Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy	22
Using former carers’ expertise in peer support for carers of people with Parkinson’s Disease	21
A systematic review on exercise and training-based interventions for freezing of gait in Parkinson’s disease	21
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein	21
Optimization of cognitive assessment in Parkinsonisms by applying artificial intelligence to a comprehensive screening test	21
A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease	21
Author Correction: Machine Learning in the Parkinson’s disease smartwatch (PADS) dataset	20
Prospective controlled study on the effects of deep brain stimulation on driving in Parkinson’s disease	20
Novel co-culture model of T cells and midbrain organoids for investigating neurodegeneration in Parkinson’s disease	20
Population fraction of Parkinson’s disease attributable to preventable risk factors	20
Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease	20
MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity	20
Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space	20
Discovering genetic mechanisms underlying the co-occurrence of Parkinson’s disease and non-motor traits	20
rTMS improves dysphagia by inhibiting NLRP3 inflammasome activation and caspase-1 dependent pyroptosis in PD mice	20
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2	20
Neurocognitive correlates of semantic memory navigation in Parkinson’s disease	19
In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease	19
Modulation of subthalamic beta oscillations by movement, dopamine, and deep brain stimulation in Parkinson’s disease	19
Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease	19
A nationwide study of the incidence, prevalence and mortality of Parkinson’s disease in the Norwegian population	19
Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei	19
Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies	19
Different effect of hypo- and hypermetabolism on cognition in dementia with Lewy bodies: are they coupled or independent?	19
Prevalence of experienced changes in artistic and everyday creativity in people with Parkinson’s disease	19
Transcranial direct current stimulation for Parkinson’s disease: systematic review and meta-analysis of motor and cognitive effects	19
Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease	19
Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia	18
A transcriptome-wide association study identifies susceptibility genes for Parkinson’s disease	18
A single centre prospective study of three device-assisted therapies for Parkinson’s disease	18
Serum neurofilament light at diagnosis: a prognostic indicator for accelerated disease progression in Parkinson’s Disease	18
Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease	18
Comprehensive real time remote monitoring for Parkinson’s disease using Quantitative DigitoGraphy	18

LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease	18
Neurofilament light chain as a mediator between LRRK2 mutation and dementia in Parkinson’s disease	18
Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease	18
Evaluation of the PREDIGT score’s performance in identifying newly diagnosed Parkinson’s patients without motor examination	18
Baseline cerebral structural morphology predict freezing of gait in early drug-naïve Parkinson’s disease	18
Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness	18
Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson’s disease: analysis of two cohorts	17
Effects of MAO-B inhibitors on non-motor symptoms and quality of life in Parkinson’s disease: A systematic review	17
Early constipation predicts faster dementia onset in Parkinson’s disease	17
Effects of deep brain stimulation frequency on eye movements and cognitive control	17
White matter and nigral alterations in multiple system atrophy-parkinsonian type	17
Social isolation and the risk of Parkinson disease in the UK biobank study	17
Towards a methodological uniformization of environmental risk studies in Parkinson’s disease	17
Exploring glymphatic system alterations in iRBD and Parkinson’s disease using automated DTI-ALPS analysis	17
The effect of levodopa on bilateral coordination and gait asymmetry in Parkinson’s disease using inertial sensor	17
Author Correction: The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data	16
Circulating blood circular RNA in Parkinson’s Disease; from involvement in pathology to diagnostic tools in at-risk individuals	16
Fecal microbiome alterations in treatment-naive de novo Parkinson’s disease	16
Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities	16
Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis	16
GPR37 processing in neurodegeneration: a potential marker for Parkinson’s Disease progression rate	16
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies	16
MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches	16
Modulation of DBS-induced cortical responses and movement by the directionality and magnitude of current administered	16
Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats	16
AccessPD as a next generation registry to accelerate Parkinson’s disease research	16
Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson’s disease	16
Association between Parkinson’s disease and the faecal eukaryotic microbiota	15
Participant-reported personal utility of genetic testing for Parkinson’s disease and interest in clinical trial participation	15
Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use	15
Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson’s disease	15
Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease	15
Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation	15
Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD	15
α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability	15
Single-cell RNA sequencing reveals peripheral immunological features in Parkinson’s Disease	15
Genetic analyses identify circulating genes related to brain structures associated with Parkinson’s disease	15
Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings	15
Accelerating Parkinson’s Disease drug development with federated learning approaches	15
Disease progression strikingly differs in research and real-world Parkinson’s populations	15