npj Parkinsons Disease

Papers
(The TQCC of npj Parkinsons Disease is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
Author Correction: Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology317
Subthalamic nucleus in patients with Parkinson’s disease encodes changes and magnitude of applied force189
Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network151
Machine learning integration of serial blood biomarkers enhances cognitive decline prediction in early Parkinson’s disease142
Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease131
Cortico-pallidal beta dynamics underlie impaired turning in Parkinson’s disease129
Differences in brain aging between sexes in Parkinson’s disease126
Transformer-based long-term predictor of subthalamic beta activity in Parkinson’s disease123
Classification of Parkinson’s disease and isolated REM sleep behaviour disorder: delineating progression markers from the sebum volatilome113
Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI104
VisionMD: an open-source tool for video-based analysis of motor function in movement disorders102
Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein98
Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease95
Corneal confocal microscopy differentiates patients with secondary parkinsonism from idiopathic Parkinson’s disease92
Proinflammatory and GABA eating bacteria in Parkinson's disease gut microbiome from a meta-analysis perspective89
Patient-centered development of clinical outcome assessments in early Parkinson disease: key priorities and advances88
CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in Parkinson’s disease88
Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions87
Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson’s disease85
Physiotherapy interventions for balance impairments in Parkinson’s disease: evidence from a systematic review and dose-response meta-analysis85
Biological aging predicts mortality in Parkinson’s patients: evidence from UK Biobank80
Phase II pilot randomized trial of zonisamide for disease modification in prodromal Lewy body disease79
Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease79
Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study78
Direct disassembly of α-syn preformed fibrils into α-syn monomers by an all-D-peptide70
Machine learning prediction of discharge destination in patients with Parkinson’s disease; a nationwide cohort study68
Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population68
Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies68
Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD68
Video-based machine learning models for predicting deep brain stimulation outcomes in Parkinson’s disease patients68
Targeting the hypothalamic a11 nucleus to treat parkinsonian-like nociceptive impairments65
A systematic exploration of unexploited genes for oxidative stress in Parkinson’s disease64
Advanced brain aging in Parkinson’s disease with cognitive impairment62
Unveiling early signs of Parkinson’s disease via a longitudinal analysis of celebrity speech recordings62
The experience of Anxiety for people with Parkinson’s disease61
The pattern of fMRI activation with STN DBS reveals symptom-specific networks61
Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease61
EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease59
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model59
The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson’s disease male mice58
Machine Learning in the Parkinson’s disease smartwatch (PADS) dataset58
Position paper: leveraging non-human primate (NHP) specificities to accelerate Parkinson’s disease and ageing research57
Does Black vs. White race affect practitioners’ appraisal of Parkinson’s disease?57
Head-to-head comparison of four cerebrospinal fluid and three plasma neurofilament light chain assays in Parkinsonism57
Inhibition of T cell infiltration and soluble TNF signaling is neuroprotective in the alpha-synuclein overexpressing mouse model of Parkinson’s disease56
Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability55
Untargeted serum metabolomics and air pollution in Parkinson’s disease55
Antiviral innate immunity induces alpha synuclein phosphorylation at serine129 in neurons independent of aggregation55
Mapping the developmental path for Parkinson’s disease therapeutics54
Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis53
JNK3 quantification in plasma: a novel biomarker for neuronal damage in Parkinson’s disease52
Single-cell analysis of the peripheral immune landscape in Parkinson’s disease: insights into dendritic cell and CD4+ T-cell transcriptomics51
In memorium, Michael Zigmond, PhD51
Resilience of striatal synaptic plasticity over early structural adaptations in premotor parkinsonism51
Park7 deletion leads to sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes49
Enrichment of gut-derived metabolites in a Parkinson’s disease subtype with REM sleep behavior disorder48
Altered perivascular spaces in subcortical white matter in Parkinson’s disease patients with levodopa-induced dyskinesia46
Characterization of the pathogenic α-Synuclein Variant V15A in Parkinson´s disease46
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies46
C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain46
Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder46
Metabotropic signaling downstream of GABAA receptors suppresses neuroinflammation in Parkinson’s disease45
Cryopreservable dopaminergic progenitors derived from human iPSCs with accelerated loss of pluripotency and early functional restoration in Parkinsonian rats43
Identification of PLOD3 and LRRN3 as potential biomarkers for Parkinson’s disease based on integrative analysis43
Plasma GFAP as a prognostic biomarker of motor subtype in early Parkinson’s disease42
A systematic review and meta-analysis of the prevalence of Parkinson’s disease in lower to upper-middle-income countries41
Immunological shifts during early-stage Parkinson’s disease identified with DNA methylation data on longitudinally collected blood samples41
Butyrate improves abnormal sleep architecture in a Parkinson’s disease mouse model via BDNF/TrkB signaling41
Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality41
Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus40
Resting and action tremor in Parkinson’s disease: pathophysiological insights from long-term STN-DBS40
Optimizing the MDS-UPDRS Part III for early-stage Parkinson’s: early supportive evidence for a limb-related bradykinesia/rigidity sub-score39
Impaired migratory phenotype of CD4+ T cells in Parkinson’s disease39
Synuclein phosphorylation: pathogenic or physiologic?38
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway38
A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease38
Genetic meta-analysis of levodopa induced dyskinesia in Parkinson’s disease38
Association of the number of minor hallucinations and well-structured visual hallucinations in Parkinson’s disease38
Reply to Matters Arising: Is congenital anosmia protective for Parkinson’s disease triggered by pathogenic entrance through the nose?38
Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease37
A 6-month longitudinal study on worsening of Parkinson’s disease during the COVID-19 pandemic37
Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson’s disease37
Baseline [18F]FP-CIT PET-based deep learning prediction of levodopa-induced dyskinesia in Parkinson’s disease37
Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints37
Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans36
Prevalence of low muscle mass and its association with orthostatic hypotension and related symptoms in Parkinson’s disease36
TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations36
Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease36
Proceedings of the world summit on parkinson’s disease36
Modulatory effect of levodopa on the basal ganglia-cerebellum connectivity in Parkinson’s disease36
Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy36
Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study35
DAT-SPECT-based subtype and stage inference in Parkinson’s disease34
Plasma GFAP and NfL associate with cerebral glucose metabolism in putative brain-first and body-first Parkinson’s disease subtypes34
CSF turnover dysfunction: a hidden early biomarker in iRBD?33
Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s disease33
Digital phenotyping of Parkinson’s disease via natural language processing33
MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients33
Differentiating tremor-dominant parkinson’s disease from essential tremor using neuromelanin- sensitive imaging and T1w/T2w ratio33
Hyposmia in Parkinson’s disease; exploring selective odour loss33
Clinical symptoms and neuroanatomical substrates of daytime sleepiness in Parkinson’s disease32
Peripheral inflammation’s variable impact on cognitive and symptomatic outcomes in Parkinson’s disease: a longitudinal and cross-sectional analysis32
Interaction of G2019S LRRK2 and metabolic syndrome in a two-hit mouse model of Parkinson’s disease: LRRK2-driven systemic depletion of pyrimidine nucleosides32
Analysis of striatal connectivity corresponding to striosomes and matrix in de novo Parkinson’s disease and isolated REM behavior disorder32
Predictors of stress resilience in Parkinson’s disease and associations with symptom progression32
Increased frontal [123I]FP-CIT binding in Parkinson’s disease patients with self-reported REM sleep behavior disorder32
Construction of a mild cognitive impairment prediction model for Parkinson’s disease patients on the basis of multimodal data32
Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases31
Timing of rehabilitation therapy initiation and all-cause mortality in parkinson’s disease: nationwide cohort study31
Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers31
Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease31
Digitizing episodic memory assessments in Parkinson’s disease via natural language processing31
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids30
Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study over 12 months30
Oral health implications in Parkinson’s disease30
Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease29
A novel peptide-based strategy to enhance GBA1 expression for treating Parkinson’s disease29
Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study29
Safety and efficacy of faecal microbiota transplantation in Parkinson’s disease29
Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease29
Time to workforce exit after a Parkinson’s disease diagnosis29
A framework for translational therapy development in deep brain stimulation29
Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease28
Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons28
Brain age gap as predictor of disease progression in Parkinson’s disease28
Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease28
Impulsive-compulsive behaviour in early Parkinson’s disease is determined by apathy and dopamine receptor D3 polymorphism28
Matters arising: In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease28
Towards scalable screening for the early detection of Parkinson’s disease: validation of an iPad-based eye movement assessment system against a clinical-grade eye tracker28
Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease27
Aerobic exercise-induced changes in fluid biomarkers in Parkinson’s disease27
Sleep disorders in Parkinson’s disease, an early and multiple problem27
Diagnostic utility of 7T neuromelanin imaging of the substantia nigra in Parkinson’s disease27
Possible role of lncRNAs in amelioration of Parkinson’s disease symptoms by transplantation of dopaminergic cells27
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease27
AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies27
Repurposing the antiplatelet drug prasugrel for Parkinson’s disease: evidence of neuroprotective effects and proteomic profiles26
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease26
To restrict or not to restrict? Practical considerations for optimizing dietary protein interactions on levodopa absorption in Parkinson’s disease26
Exploring the link between essential tremor and Parkinson’s disease26
Lipid profiling of Parkinson’s disease brain highlights disruption in Lysophosphatidylcholines, and triacylglycerol metabolism26
Video-based quantification of hand postural tremor without external references. Integrating postural tremor quantification into visionMD26
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)26
Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory26
Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease26
A spatiotemporal hypergraph self-attention neural networks framework for the identification and pharmacological efficacy assessment of Parkinson’s disease motor symptoms25
Structural underpinnings and long-term effects of resilience in Parkinson’s disease25
Lack of full sequencing GBA1 studies for patients with Parkinson’s disease in Latin America25
Varying patterns of association between cortical large-scale networks and subthalamic nucleus activity in Parkinson’s disease25
Microstructural but not macrostructural cortical degeneration occurs in Parkinson’s disease with mild cognitive impairment25
Self-perceived life course sleep duration trajectories and risk and age at onset of Parkinson’s disease25
EEG alpha peak frequency: cognitive impairment severity marker in isolated REM sleep behavior disorder25
Sentence completion in progressive supranuclear palsy following transcranial direct current stimulation25
Spatial variations and precise location of substantia nigra hyperechogenicity in Parkinson’s disease using TCS-MR fusion imaging25
Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson’s disease mouse model25
Modified version of unified multiple system atrophy rating scale for remote video-based assessments25
Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson’s and inflammatory bowel disease25
Glutamatergic synaptic resilience to overexpressed human alpha-synuclein25
Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease25
A generalizable and open-source algorithm for real-life monitoring of tremor in Parkinson’s disease24
Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy24
Misfolded protein deposits in Parkinson’s disease and Parkinson’s disease-related cognitive impairment, a [11C]PBB3 study24
Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder24
Association of wearable sensor-based gait analysis with phenoconversion trajectories in idiopathic REM sleep behavior disorder24
Genome-wide association study of copy number variations in Parkinson’s disease24
Clinical subtypes in patients with isolated REM sleep behaviour disorder24
Data-driven subtyping of early Parkinson’s disease via mutual cross-attention fusion of EEG and dual-task gait features23
Home-based deep sleep modulation in Parkinson’s disease: extension study on long-term feasibility and sleep-related outcomes23
Genetically-informed prediction of short-term Parkinson’s disease progression23
A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease23
Brain-derived extracellular vesicle proteomics reveals neuroprotection induced by the ARB candesartan in Parkinson’s disease patients23
The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson’s disease23
Metagenomics indicates an interplay of the microbiome and functional pathways in Parkinson’s disease22
Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease22
α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies22
Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space22
Discovering genetic mechanisms underlying the co-occurrence of Parkinson’s disease and non-motor traits22
Prospective controlled study on the effects of deep brain stimulation on driving in Parkinson’s disease22
Altered heart-brain coupling in awake patients with isolated REM sleep behaviour disorder22
Synaptic vesicle characterization of iPSC-derived dopaminergic neurons provides insight into distinct secretory vesicle pools22
Using former carers’ expertise in peer support for carers of people with Parkinson’s Disease22
Central biogenic amine deficiency with concomitant exploratory behavioral deficits in Dnajc12 knock-out mice22
Author Correction: Machine Learning in the Parkinson’s disease smartwatch (PADS) dataset22
Pallidal beta power is associated with depression in Parkinson’s disease21
Neurocognitive correlates of semantic memory navigation in Parkinson’s disease21
Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei21
rTMS improves dysphagia by inhibiting NLRP3 inflammasome activation and caspase-1 dependent pyroptosis in PD mice21
Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease21
A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease21
The biological clock in parkinson’s disease: mechanisms and chronotherapy21
Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease21
Advancements in invasive and non-invasive neuromodulation for Parkinson’s disease: current findings and future directions21
Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease21
Prevalence of experienced changes in artistic and everyday creativity in people with Parkinson’s disease21
MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity20
Different effect of hypo- and hypermetabolism on cognition in dementia with Lewy bodies: are they coupled or independent?20
Modulation of subthalamic beta oscillations by movement, dopamine, and deep brain stimulation in Parkinson’s disease20
Population fraction of Parkinson’s disease attributable to preventable risk factors20
In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease20
Novel co-culture model of T cells and midbrain organoids for investigating neurodegeneration in Parkinson’s disease20
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT220
Comprehensive real time remote monitoring for Parkinson’s disease using Quantitative DigitoGraphy20
AccessPD as a next generation registry to accelerate Parkinson’s disease research20
Transcranial direct current stimulation for Parkinson’s disease: systematic review and meta-analysis of motor and cognitive effects20
Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies20
Association of retinal neurodegeneration with the progression of cognitive decline in Parkinson’s disease20
StimVision: smartphone video kinematics to optimize DBS programming in Parkinson’s disease19
Inherent variability limits clinical utility of reproducible Parkinson’s transcriptomics signatures19
Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition19
Effects of deep brain stimulation frequency on eye movements and cognitive control19
Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson’s disease: analysis of two cohorts19
Social isolation and the risk of Parkinson disease in the UK biobank study19
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies19
Fecal microbiome alterations in treatment-naive de novo Parkinson’s disease19
Serum neurofilament light at diagnosis: a prognostic indicator for accelerated disease progression in Parkinson’s Disease19
Prominent role of PM10 in the link between air pollution and incident Parkinson’s Disease19
Towards a methodological uniformization of environmental risk studies in Parkinson’s disease19
Unraveling the role of GBA1 genotype in axial signs response to subthalamic deep brain stimulation19
MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches19
A single centre prospective study of three device-assisted therapies for Parkinson’s disease19
Baseline cerebral structural morphology predict freezing of gait in early drug-naïve Parkinson’s disease19
Cerebral perfusion imaging predicts levodopa-induced dyskinesia in Parkinsonian rat model18
Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson’s disease18
Perivascular spread of CSF-derived α-synuclein oligomers drives region-specific Parkinson’s-like pathology18
Altered wakeful theta activity characterizes levodopa-induced dyskinesia in Parkinson’s disease18
Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson’s disease patients18
High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging18
GPR37 processing in neurodegeneration: a potential marker for Parkinson’s Disease progression rate18
Plasma neurofilament light chain in early Parkinson’s disease predicts motor complications: a prospective cohort study18
Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness18
L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy18
The barriers to receiving health care for people with Parkinson’s from predominantly Asian backgrounds in the UK18
Multi-omic insight into the molecular mechanism of cuproptosis-related genes in the pathogenesis of Parkinson’s disease18
Neurofilament light chain as a mediator between LRRK2 mutation and dementia in Parkinson’s disease18
Driving motor cortex oscillations restores plasticity and improves bradykinesia features in Parkinson’s disease18
Exploring glymphatic system alterations in iRBD and Parkinson’s disease using automated DTI-ALPS analysis18
Long-term oral glucocerebrosidase activator reduces soluble α-synuclein oligomer accumulation in Parkinsonian LRRK2 mutant mouse brain17
Wearable-sensor based walking and non-walking measures as progression markers in early to mid-stage Parkinson’s disease17
Single-cell RNA sequencing reveals peripheral immunological features in Parkinson’s Disease17
Sleep and Parkinson’s disease: a population-based study from the CHARLS cohort17
Modulation of DBS-induced cortical responses and movement by the directionality and magnitude of current administered17
Strain-specific effects of Desulfovibrio on neurodegeneration and oxidative stress in a Caenorhabditis elegans PD model17
Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis17
Circulating blood circular RNA in Parkinson’s Disease; from involvement in pathology to diagnostic tools in at-risk individuals17
Clinico-physiological correlates of Parkinson’s disease from multi-resolution basal ganglia recordings17
Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling17
Association of fecal short-chain fatty acids with clinical severity and gut microbiota in essential tremor and its difference from Parkinson’s disease17
Association of GBA1 status and sex with depression severity and progression in Parkinson’s disease17
Accelerating Parkinson’s Disease drug development with federated learning approaches17
Perspective on the current state of the LRRK2 field17
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